David Sinclair’s 2023 UPDATED Supplement Protocol plus ,Sinclair’s New Theory of Aging, Explained.

David Sinclair’s 2023 UPDATED Supplement Protocol | And WHY He Takes It Wellness Messiah with Rimon 20.7K subscribers Join Subscribe 3.2K Share 118,820 views Aug 10, 2022 If you’ve been following Dr David Sinclair, you know he updates his supplement protocol from time to time. And in each interview, he gives one piece of explanation to what he does. And certain supplements that appear in one interview, he does not mention them in other interviews. Sometimes it’s hard to follow his protocol today. Since, I know Sinclair’s work since 2007, before he went public in 2019. Here, I have collected for you from a variety of sources, including Sinclair’s book, trying to figure out EVERYTHING he takes today and how much from each supplement. And, you’ll find a very spicy comment from Sinclair about resveratrol. ---------------------------------------------------------------------------------------- ✅ Brad Stanfield vs David Sinclair on RESVERATROL • David Sinclair VS... ✅ David Sinclair's Original RESVERATROL Study: Amazing Discovery & Analysis • David Sinclair St... ---------------------------------------------------------------------------------------- Becoming a channel member on Patreon & get benefits: Pateron: https://www.patreon.com/WellnessMessiah ---------------------------------------------------------------------------------------- DISCLAIMER & FAIR USE Copyright Disclaimer under section 107 of the Copyright Act 1976, allowance is made for “fair use” for purposes such as criticism, comment, news reporting, teaching, scholarship, education and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use. ---------------------------------------------------------------------------------------- More Longevity Research Videos from Us: ✅ Suppress TOR by avoiding excess protein How to Suppress TOR Pathway Naturally • How to Suppress T... Protein Impact on Longevity Explained • David Sinclair VS... How Much Protein EXACTLY You Need • How Much PROTEIN ... ✅ Integrate anti-aging foods that target longevity pathways. Collagen for Longevity and Young Skin / 9q3rnfpqwp Collagen Deeper Analysis (Soon) ✅ Reduce inflammation by replacing cheap vegetable oils with healthy fats Omega 3 Supplement and Foods • Omega 3 Supplemen... ✅ Move or exercise soon after meals to burn off meal's glucose Yet to be released ✅ Cycle stress and cortisol Yet to be released ✅ Activate deep cleaning inside your body by integrating long fasting ✅ Intermittent Fasting: Intermittent Fasting - How it Works? [PODCAST] • #23-Intermittent ... How to Do Intermittent Fasting: Complete Guide [PODCAST] • Video ✅ Improve Your Sleep Quality Guide • The MISSING Piece... ✅ Increase the intensity of your exercise, but do it intermittently, Cardio HIIT for Longevity • David Sinclair & ... ✅ Take longevity supplements Resveratrol Controversy Explained • David Sinclair VS... Taking Resveratrol Correctly: • Fact-Checking: Sh... ---------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------- The Wellness Messiah podcast is available on Spotify, Apple Podcasts, and Overcast. ---------------------------------------------------------------------------------------- Credits: Scott Buckley Disclaimer & Disclosure: The information in this video and/or at this channel is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge, educational and information from the research and experience of Rimon, who encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. Rimon is not a medical doctor. If there is a contradiction between the advice here to your doctor or local authorities, always go with the doctor and the authorities. Statements made, or solutions suggested in this video and/or at this channel are not intended to diagnose, treat, cure, or prevent any disease. The statements are not contradictory to first following authorities' guidelines of social distancing and hygiene. Key moments View all 264 Comments rongmaw lin Add a comment... Wellness Messiah with Rimon Pinned by Wellness Messiah with Rimon Wellness Messiah with Rimon 7 months ago (edited) ✅ Brad Stanfield vs David Sinclair on RESVERATROL https://youtu.be/Hsk-TyjywR4 ✅ David Sinclair's Original RESVERATROL Study: Amazing Discovery & Analysis https://youtu.be/Js_l_G1x8V4 17 Reply 3 replies NavyDoc NavyDoc 2 days ago Thank you for doing the leg work for the rest of us in putting this together. It is very much appreciated. 2 Reply Santiago Gold Santiago Gold 5 months ago Thanks for organizing these videos and data. It makes things much easier to reference Sinclair 15 Reply MGAMES MGAMES 3 months ago Very well done sir. I am now a fan after this video. Keep the viewers updated. I want to know if sinclair changes anything. But also, what happens if nmn is removed from the market? What to take if that happens. Would love to hear a video on that 6 Reply Otto Otto 7 months ago (edited) Great video! Thank you!!! After having watched all your videos I'm still insecure about how much resveratrol to take (30-50mg or 500mg or even 1g like Sinclair does??)....Hopefully your forthcoming videos will help finding the right dosage... As far as i know wheatgerms contain much more spermidine than the sources you mentioned. 15 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies Classical Liberal Warrior Classical Liberal Warrior 1 month ago I just ran across this channel today (Feb. 6, 2023) and it seems pretty good. I'm a fan of Dr. David Sinclair and Dr. Brad Stanfield, and I've attended two high-quality international conferences on longevity. Almost all this stuff is quackery and snake oil, but perhaps Rimon's content is not. 1 Reply 1 reply Triangle Dancing Triangle Dancing 7 months ago This is another very informative video. I just recently found your channel and really enjoy the content, especially when you dive into the details of Sinclair's comments and the studies. Since this one is about supplements, have you considered doing some videos on liposomal supplements? A lot of these longevity substances have very poor bioavailability. Using a liposomal delivery system dramatically increases the amount that gets into the bloodstream (almost all of it from what I've heard) and also facilitates entry into the cells where it is needed. I'm in the process of switching to liposomal (or phytosomes, which is very similar and does pretty much the same thing as liposomes) supplements where they are available for the stuff I take. One last thing, Metformin is mentioned in this video, and that is not typically available to people. You've also mentioned Rapamycin on your channel I believe as a longevity molecule. It turns out there are natural mimetics of those substances. On that reasoning I added ashwagandha, EGCG, and ginseng to my stack. See the study below for scientific support: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723685/ 11 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 4 replies Henrik Madsen Henrik Madsen 6 days ago Great to watch your summary!! Sinclair is pretty sloppy when he reports on his protocol. Fantastic to have you to sum it up. Great work. Thanks a lot. Reply Johnny Murray Johnny Murray 1 month ago Thank You for the video. It's quite informative! I appreciate it 👍 1 Reply Jo Smith Jo Smith 2 weeks ago Just started resveratrol (for 1st time) at night after a meal, with coffee with the 2 tsp of olive oil and coconut milk. Not as bad as thought it might be. (after watching one of Sinclair's videos, ad lib.) Have to wait and see literally, results. Read about coffee as antioxidant. Also have read that it stops vitamin absorption. (Hopefully just slows time of absorption.) 2 Reply 3 replies Birgitta Devlin Birgitta Devlin 4 months ago How about this study concerning A-HgM (Metformin f.ex.) exposure in patients with T2D was associated with reduced risk of MS in patients younger than 45 whereas in patients older than 45, exposure to A-HgM was associated with an increased risk of newly diagnosed MS, particularly in women. Would this then also apply to Berberine? 2 Reply antcam007 antcam007 4 months ago He says in an interview that the resveratrol he takes is "the white stuff, not the brown one" . I thought you would like to mention it in your update. 4 Reply Christopher Ellis Christopher Ellis 7 months ago (edited) Have been aware of D3K2 since learning that my mother died from Aortic Stenosis: calcification of the heart. Thank you, margarine. Res and quercetin are in my protocol 7 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 4 replies Bryan Dalle Stelle Bryan Dalle Stelle 7 months ago I think he updated the way he takes resveretrol. I heard ( I don't remember the interview) he now dissolves resveretrol in olive oil and a little bit of apple cider vinegar. 5 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 4 replies Jay Pena Jay Pena 4 days ago When talking about vitamin K2 supplement dosage it’s important to be more specific on the type. I believe he was talking about MK-7 K2. You also have MK-4 which in most supplements is dosed higher than MK-7. Reply JWV JWV 6 months ago Thank you for your honest work! 👍 6 Reply Wellness Messiah with Rimon · 1 reply Dragon Ryder Dragon Ryder 2 days ago How helpful - thank you so much!! Reply Ivalú Ivalú 4 months ago Very good summarize. Thanks! Reply A T A T 7 months ago I would really like to clarify about Quercetin - it’s not safe to take it every day, it can damage healthy celks, and I dont think Sinclair is doing it everyday either….the study that he brings up (and I can look it up) used quercetin in hit-and-run fashion meaning 3 days in a row then 6 weeks break. Because there is no point to keep taking it everyday - once u remove senescent cells. 52 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 46 replies Arnold Pillay Arnold Pillay 6 months ago Thank you Doc... appreciate your advice 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies Antony Stringfellow Antony Stringfellow 5 months ago I'm a little surprised David takes so much of so many of these compounds. Most of them are synergistic to the point of actually amplifying the effects of one another. The effects of Metformin and Aspirin, taken together, is more than the sum of each taken alone. The effects of Metformin and Resveratrol, taken together, is more than the sum of each taken alone. Metformin, Aspirin, Resveratrol and Quercetin are all synergistic, with many overlapping effects. I have taken all of these, and in similar doses (but 1 g Metformin per day) but only for 4 weeks, as a purge. I wouldn't want to risk doing this long-term. The only one I take every day is Metformin and that's because it's the only one of these compounds that has been proven to extend human life and has an excellent safety profile. On the other hand, one study on rats showed that Quercetin increased the occurrence of tumours. Starting Monday, I'll be taking the polyphenol, Pterostilbene together with NR as they seem to have a powerful anti-cancer effect when taken together. Pterostibene has 4X the bioavailability of Resveratrol so I'll only be taking 100 mg per day. I'll also be starting with sulforaphane and eating much more broccoli together with mustard seeds (trying looking that one up). When I was taking Resveratrol and Quercetin (my purge) I mixed them together with soya lecithin, on a slice of wholemeal bread. Both the lecithin and the wholemeal bread boost absorption, especially the lecithin, which has a strong affinty with water. I also mixed in 500 mg of VitC which I had in paste form, in capsules. The Vit C and lecithin help to protect the Quercetin, the lecithin in the stomach and the Vit C in the bloodstream, so it has more time in your system before being metabolised. Anyway, thanks for keeping us up to date.... really appreciate your videos! 10 Reply 10 replies Kirsti Cheetah Kirsti Cheetah 1 month ago Great video! Just one thing: Taking drugs like Metformin is not natural and not healthy, it has side effects. If you do not eat sugar, you do not need Metformin! I do low carb - high fat - medium protein and IF and most days OMAD. Do sports in a fasted state. Take Pterostilbene on my resting days, not when doing sports. 5 Reply bernhardwalther bernhardwalther 7 months ago Great video as usual now. Thanks not to take holidays on that this summer 👌👍 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Christopher Stebbins Christopher Stebbins 6 months ago Hi Rimon, Do you address, or can you address, Berberine as an alternative to Metformin? My doctor is not really up on longevity research, and she refused to prescribe Metformin to me. However, Berberine is touted as a natural alternative to Metformin, with many of the same benefits, plus others. Of course, I purchase Berberine online, so it's more accessible. Thanks in advance, Chris 7 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 4 replies Aurielle Nazro Aurielle Nazro 4 months ago I do not have a prescription for metformin. So I decided to substitute it with Berberine since it is very effective in reducing blood sugar. I would like your opinion on this…. 8 Reply 2 replies Anthony Rude Anthony Rude 9 days ago You left out the most important part... Where does he get his supplements? I think a company was mentioned in a clip but I didn't catch it. Do you have a company name or link? Thanks Reply Rodrigo Terra Rodrigo Terra 6 months ago Great video but you forgot to mention that he said that he also takes statins , cause of his family history . I m curious about that cause i have the same issue ! Thank you ! 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 4 replies Tony Castani Tony Castani 5 months ago (edited) Why does Dr Sinclair still take such large doses of Resveratrol even though in his own studies low doses worked better for longevity? In one of his recent interviews he mentioned that he now takes Resveratrol every other day. 8 Reply 1 reply Earth Gen Earth Gen 1 month ago Thanks for summary of information! Reply Ryan Doherty Ryan Doherty 6 months ago So am I to understand just to be clear that he takes virtually all of these supplements at the same time or around the same time in the morning? I don't hear him or yourself mentioning that he takes anything later on in the afternoon or evening. (I heard him mention some people take NMN at night time). Just curious, is he taking D, K2, Resveratrol, Quercetin, Fisetin, NMN, Spermedine, and Tri methyl glycine all in the morning? Thank you! 1 Reply Wellness Messiah with Rimon · 2 replies DingusCirc DingusCirc 5 months ago Its not needed to skip Metformin before exercise.... Especially if you are using TRT. Reply Android Samsung Android Samsung 5 months ago What about replacing Metformin with Chromium Picolinate and Bitter Gourd? 2 Reply Ami Loh Ami Loh 5 days ago (edited) I need to know which multi vitamins(which brands) especially B complex are best without any side effects Reply Gym'N'Crypto Gym'N'Crypto 5 months ago What cures for aging is he actually working on? 1 Reply Popel Grüner Popel Grüner 7 months ago May I add to the Spermidine question that you find HIGH concentrations of it in wheat germ. It is up to three times the concentration of mushrooms. At least that is what the web says. 3 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 3 replies Mark Fischer Mark Fischer 12 days ago I have enough different kinds of supplements to start a health food store. After seeing your presentation on resveratrol I stopped. It appears to me that in high doses used continuously it might be dangerous. I'll stick to red wine and berries. 1 Reply Gino Gino 2 months ago The spermidine levels mentioned would be from raw not cooked so cooked would be substantially less. Reply Jeffrey Harper Jeffrey Harper 1 month ago I saw a video by Dr. Berg where he stated that you can take 10,000 IU's of vitamin D3 with 100mg of vitamin K2 (MK-7 form only due to it's increased bioavailability) and not be concerned with calcium build up in the arteries, therefor you might be safe doing that. Reply 2 replies ginacardarella ginacardarella 2 weeks ago I enjoying the way you break down the video 1 Reply Andrew Kershaw Andrew Kershaw 6 days ago Sinclair said on Huberman lab that he pulses resveratrol, but does not go into detail. Reply Steven Brown Steven Brown 4 months ago What about rapamycin? Some are saying it is the most effective, but no mention of it here. 4 Reply Cesar Villalobos Cesar Villalobos 5 months ago Thaaaaaank you because you speak clearly! Reply Xochitl Morales Xochitl Morales 3 weeks ago thank you for the information, NMN and Resveratol = NAD+? 1 Reply 1 reply William Lovett William Lovett 13 days ago Thank you for this Reply Thomas Rudder Thomas Rudder 2 weeks ago Why is it a big secret. The guy sells a book, puts himself out there, and claims to reverse aging, but is reluctant to put his ingredient list out there? WHY? Also the guy seems to be about as interesting as a beach ball. 2 Reply 1 reply Kajt23 Kajt23 7 months ago Great video! 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Mohammad Alaliirhabiubidu Mohammad Alaliirhabiubidu 10 days ago how about gene editing the cells so that the gene cells of specific part of the body is harvested, turned into a partial stem cell, then be put back into the body replacing aging cells and de aging the body parts bit by bit like visions ship of theseus. Reply riteshnayak80 riteshnayak80 1 month ago (edited) What about Astaxanthin, which is known to be 3000 times more antioxidative than Resveratrol?? What about ayurvedic Shilajit (asphaltum/mineral pitch) ? 4 Reply 1 reply Anca Romanov Anca Romanov 2 months ago Has anyone tried liposomale NAD+ , (have found softgels mit TMG directly in them ) ? Reply Ed Rock Ed Rock 3 weeks ago (edited) The fact that he is updating them means he doesn't really know. And we are all going to die. Reply C l Reed C l Reed 6 months ago Thank you! 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply palden palden 1 month ago All the Resveratrol I ordered until now was always brown and not white in color like Dr. Sinclair says it should be. Anybody knows a Resveratrol supplement in which actually the powder is white? 1 Reply 4 replies Sabreen Mow Sabreen Mow 3 months ago how do you measure 1 gm of resvertrol or nmn? Reply 2 replies Abdi najib isaak Abdi najib isaak 10 days ago What are the supplements that will I take every day please I need the least? Reply Tati Ana Tati Ana 6 months ago I don't get why he's such a guru in aging. He looks his age. He looks middle-aged. Nothing wrong with that but he's a millionaire from all his work and he doesn't look younger than his age at all. 3 Reply 6 replies Ian Pipe Ian Pipe 1 month ago Hmmm. When listening to this guy, he comes across as being envious and condescending when Dr Sinclair may adjust the use of what he may be taking. It sounds like jealousy. Isn't testing and adjusting the supplements part of assessing what the right level of dosing and compatability of products to produce the best products? He is experimenting on himself, so why is that a problem? I don't get the reason for the snide comments with the tone of, "....well, he hasn't perfected it yet, has he?". It's work in progress. Reply Taylan Ulukır Taylan Ulukır 1 month ago I thought he is also taking alpha Lipoic acid? Did he stop taking it? Reply jane bond jane bond 1 month ago What is best to help memory loss of things U R taking Dr. Sinclair? Reply Scott Mccal Scott Mccal 2 months ago Great video Reply Aaradhika Chopra Aaradhika Chopra 4 days ago Anybody know how many months to take without a break..? And how many days in a week..? Reply The Analyst The Analyst 3 months ago What company is owned by dr sanclair that produces NMN? Reply Otto Otto 6 months ago Today i saw a new video where he says that he recently only takes 500 mg NMN. 5 Reply Frank K Frank K 2 weeks ago What if you exercise every other day? Reply MrBrianDuga MrBrianDuga 5 months ago Does anyone know what brands Dr Sinclair uses? He doesn't seem to disclose that in interviews. Reply 3 replies Peter Pau Peter Pau 3 weeks ago Is NMN just a derivative of Vitamin B3 1 Reply CheetahBRFC CheetahBRFC 7 months ago Do you think you can take berberine at night instead of metformin? Whay dose would you take if yes? 3 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 5 replies anne thomas anne thomas 6 months ago I'm vegan and was wondering if iI still need b12 as I'm taken nmn and tmg 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Alexander Sverdlov Alexander Sverdlov 6 months ago Does anyone know WHERE is Sinclair taking his supplements from? Most sellers on Amazon sell fake products from noname garage companies.. 3 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies Francine Bales Francine Bales 7 days ago Were are those suplement hiding…can we buy them Reply Burt the Man Burt the Man 6 months ago It all doesn’t matter. At the end of life we will experience huge disappointment cause we’re all going to die in a relatively short time. 2 Reply 4 replies Lip stick Lip stick 1 month ago What about NAD +??? Reply Samantha Zone Samantha Zone 2 weeks ago 13:11 for summary thanks again 1 Reply V V 3 days ago Thanks for summarizing, but as for vitamin D, you shouln't take it in the evening, youl'll have problem getting to sleep. Reply The Hunter The Hunter 10 days ago How many people can afford to be taking all these supplements? Reply RR Fitness LV RR Fitness LV 1 month ago Why not just to eat foods rich in those compounds? 🤨 Reply Mark Ferris Mark Ferris 1 month ago What do think about L CARNOSINE ? Reply Peter Pau Peter Pau 3 weeks ago Do you know Vitamin K2 and Vitamin D3 are fat soluble. So if you do not have a good Liver and Gallbladder. You can not properly breakdown and hence cannot absorb these vitamins properly meaning you do not know how much of Your daily intakes Reply Michelle S Michelle S 2 weeks ago How old is Dr Sinclair? Reply 1 reply ginacardarella ginacardarella 2 weeks ago NMN is sooo expensive Reply Atlantean Wizard Atlantean Wizard 12 days ago (edited) "Metformin enhances and mimics the benefits of fasting"..so why not just do fasting. 1 Reply greg l greg l 2 months ago I wonder why he doesn't take astaxanathin? 2 Reply mweb1 mweb1 3 weeks ago I have too much vitamin D. Reply endicotto endicotto 5 months ago Blah blah. I found that all out on my own. Who knows who’s right? 1 Reply Ed Rock Ed Rock 3 weeks ago I eat m&ms everyday. 1 Reply Francine Bales Francine Bales 7 days ago And you should add were to find it Reply Zegenda Zegenda 1 month ago (edited) Whaat about the statine? Reply Sandra Sandra 11 days ago Why would you to blunt growth hormone and melatonin. Reply Edward Edward 3 weeks ago The fact that he uses chemical drugs as part of his supplementation is a turn off for me. Reply Joya Borthakur Joya Borthakur 7 months ago (edited) How many of you are afraid of death?? Reply 2 replies Kim Hjortsbjerg Kim Hjortsbjerg 4 months ago This is bad ! There is no thumbs up symbol below the video ? Reply Sandra Sandra 11 days ago I don’t think he is trustworthy. Reply Island Light Photo Dot Com Island Light Photo Dot Com 2 months ago messiah??? haha.... not for me... Reply David G. Johnson David G. Johnson 1 month ago Very negative video of Dr. Sinclair as usual. 1 Reply Walker Hospitality Walker Hospitality 3 days ago I wouldn't be following this guy. He is not bright enough to avoid the toxic jabs. Reply mweb1 mweb1 3 weeks ago Rimon is no messiah. Reply cornstar cornstar 2 weeks ago Huckster Reply Nan Kilkeary Nan Kilkeary 5 months ago What is your full name? What are your credentials? Are you a doctor? Do you have a Ph.D? A master's in medical science? Do you have any credentials? You make it look like you have interviewed David Sinclair and others, but I know -- from having followed Sinclair's work (who has a Ph.D., worked at MIT, heads the anti-aging program at Harvard) that you have lifted video form from other interviewers' work. You make statements about studies, but do not show their sources. In other words, nothing that you say can be validated. You may not be a fraud, but you give anyone who truly follows this work no reason to believe you. And the incredible arrogance and narcissism of calling yourself a Messiah! 3 Reply Schu2505 Schu2505 7 months ago (edited) He also takes a statin for a genetic predisposition for high cholesterol. This is strange because he eats coconut yogurt, which is high in coconut oil, which is well known for raising cholesterol. Also, the 2008 Cell study mentioned only indicates improvements in longevity in the EOD feeding and HC diet cases. In fact, in the SD (standard diet) case, lifespan was decreased with low dose of Resveratrol. (Fig 4, graph E: https://www.cell.com/cell-metabolism/pdf/S1550-4131(08)00182-4.pdf) 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · Dr. Physionic 29.7K subscribers Subscribe 2.9K Share 95,510 views Jan 23, 2023 #drsinclair #healthscience JOIN MY PHYSIONIC SOCIAL NETWORK Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity Join the Physionic Insiders [Premium]: https://bit.ly/PhysionicInsiders HIRE ME FOR CONSULTING: https://bit.ly/3dmUl2H DONATIONS FOR A SCIENCE BASED CAUSE Patreon: patreon.com/PhysionicPhD WHERE ELSE IM ACTIVE: Email: http://bit.ly/2AXIzK6 Podcast: http://bit.ly/2PThKz0 Instagram: http://bit.ly/2OBFe7i Created with Biorender. #drsinclair #agingresearch #healthscience Chapters View all 295 Comments rongmaw lin Add a comment... Talia Talia 1 month ago (edited) This is a fantastic study and thanks for your breakdown analysis. I totally agree - and this now explains past studies that indicated that only 5–10% of all cancer cases can be attributed to genetic defects, whereas the remaining 90–95% have their roots in environment and lifestyle eg smoking, diet, alcohol, UV, pollutants, infections, stress, obesity, physical inactivity. Looking fwd to more on human studies too and your analysis. I will share this with my friend who is a genomics principal scientist. 71 Physionic Reply 5 replies wilmer walton wilmer walton 1 month ago Your presentation was outstanding. Just as my head began to hurt, you injected a bit of comic relief, then got right back into it. I appreciated the conclusion where you informed us that we should keep doing what we already know we should be doing to maintain our health. As is your practice you left me wanting more, much more. 29 Physionic Reply Physionic · 1 reply paninopanini paninopanini 3 weeks ago These subjects are soo hard to explain, even to stem field students. I admire how you wanted to share this information in a more "people in general friendly" manner. Amazing how many aspects of aging is in our hands. I wonder how technology, if any, have a impact in our epigenome, the constant use of our phones and social media I think can make a impact in some way. what a great video 9 Physionic Reply Physionic · 2 replies ScienceGuy ScienceGuy 3 weeks ago I'm glad to see you give credit to how hard molecular biology is. When I was in undergrad for biology, it was the most challenging course. 4 Physionic Reply sabin cioflec sabin cioflec 1 month ago Petition for a video on demon possession and longevity in mice. 108 Physionic Reply Physionic · 5 replies MetricZero MetricZero 2 weeks ago What I would love to see from you is a stack of 'anti-aging' supplements and some research on why each are chosen. 2 Physionic Reply Physionic · 1 reply photo200 photo200 1 month ago (edited) Great video, thanks. So the primary takeaway is that David Sinclair has demonstrated that epigenetic damage is more likely to be causing gradual aging than gene damage. The secondary takeaway is that Yamanaka factors can potentially reverse some of this epigenetic damage, but are too dangerous to use, presumably because if you overshoot, you end up converting everything to stem cells..?.. So, a few questions: 1. How were the Yamanaka factors controlled in the experiment, so as to unwind the epigenetic damage without damaging the mice? 2. How will this affect the direction of research? Will it focus on how to safely use Yamanaka factors, perhaps by only using some of them? Or are there other methods that show promise? 4 Reply Ivanna Zhilinskaya Ivanna Zhilinskaya 1 month ago This was fantastically presented. Thank you for the information presented in a clear way. 10 Physionic Reply Physionic · 1 reply Ray Fleming Ray Fleming 1 month ago How big of a roll does epigenetic tagging play with cancer versus genetic mutation. I worked as a health physicist and our story was the cancer being caused by generic mutations. But the fact that many people get the same types of cancers means it could not be due to strictly random mutations. Epigenetic differences could be a better explanation for how cancer types are so reproducable. 3 Reply Andrew W. / NH Andrew W. / NH 1 month ago Great presentation as always nicolas. It makes sense now that the "epi-" in front of genetics meaning on top - may actually refer to these "tags" you refer to. I am always ambivalent on topics involving NAD precursors supplements. While my biochemistry is admittedly pedestrian, there appears to be perplexed findings on their use on present literatures (particularly B3/NMN/NR and or even Metformin). Perhaps food for thoughts in the future? many thanks. live-it-forward, AW. 6 Physionic Reply Physionic · 1 reply Mark St. Pierre Mark St. Pierre 9 days ago Concise as always, highly informative, captivating delivery and graphics. Great video Physionic Reply Physionic · 1 reply Draziell Draziell 1 month ago These new videos that you breakdown the science are the best!! Please keep doing it!! 7 Physionic Reply Physionic · 1 reply Daniel Gutierrez Daniel Gutierrez 1 month ago Woooow man what a summary. I am just discovering your channel, but this review saves me a lot of time researching for my health and defining my lifestyle. 4 Physionic Reply Physionic · 1 reply cassandra stewart cassandra stewart 1 month ago Impressive analysis of the study, and so easy on the eyes, what a blessing 5 Physionic Reply KoiRun KoiRun 1 month ago Finally a very clear explanation of what an epigenome is for me! 8 Physionic Reply Mihaella A. Mihaella A. 3 weeks ago Love how you are joking, to make sure our attention span of a goldfish is on point! Thanks for this presentation, very well done! 2 Physionic Reply Physionic · 1 reply Physionic Physionic 1 month ago (edited) Put a lot of work into this one - hope it’s clear and informative. If you have related questions, feel free to ask. Also, I know nothing about the NMN situation and Dr. Sinclair. This is merely an evaluation of his largest scientific work. 20 Reply 1 reply practicaltheory practicaltheory 1 month ago Would love to hear more on point 2. I mean it seems obvious to me the basic nut has been cracked and it also seems silly a 98 year old can't just roll the dice if he chooses to do so, but that's what regulatory capture will get for you. Gotta love corruption! 3 Reply Ro Blake Ro Blake 1 month ago The Epigenetic cause of aging has been shown in multiple ways. Working with fish, this evidence has become more specific. Even perfect RNA cannot make protein/peptides/hormones without having all necessary amino acids. The current evidence points to a lack of amino acids due to changes in the microbiome. It looks like their may be a universal overgrowth of parasitic bacteria over time. Humans can have trillions more of specific gut bacteria as they grow older. After all, old people appear to be starving... 7 Reply 2 replies Little Voice Little Voice 1 month ago Would you consider a video on a common age associated disease such as osteoarthritis? I'd be very interested to know effect diets (such as anti-inflammatory, sugar-free) Supplements (collagen, UC-ii, boswellia, glucosamine, vit d, turmeric, etc) Red light therapy There's a lot of information online. But I wonder how much is back by science. I'm desperate to help my mother who is struggling with hip pain from osteoarthritis 6 Physionic Reply Physionic · 4 replies Lars Nyström Lars Nyström 1 month ago Your exposition of Sinclairs ideas and approach is very clear. I like to see more from you with this quality. The thing I wondered about is how equal the epigenetic changes of aging and the experiment were. And how equal the result of "repairing" those was to the none-aged ones was. What's unclear to me is if the epigenetic clock is a systematic change. Or if it's just a gross chaotic change in one direction. So, a video about that would be appreciated, if this is someting the researchers even know. I suspect they don't really know, or they would have been more clear about it. I noticed that you said nothing about that the mice being treated with anti-aging looked younger. And if they lived longer than damaged mice which didn't receive treatment. (Of course there would be some of those?) Until I see some mice actually getting younger, I don't really belive that Sinclair has proved his thesis. Making mice older isn't really the problem! 2 Reply Bob Le Clair Bob Le Clair 1 month ago Epigenetics is still a new word, a new idea for a lot of us, I just heard of the word about a year ago ,it fits in with many of our beliefs ,whether science or religion, a healthy lifestyle and healthy beliefs and memory leads to a healthy future, the memory part is in your young stem cells, that your parents forgot to freeze ( cryogenics) when you were young born, if you want to stay young, think young, how do you think placebos work, a positive mind is a young mind, Epigenetics, your genes are carryovers from your grandparents ,ancestral and environmental, The environmental part and that of the mind included, brings us closer to moments of notice to change in epigenetics, What is the epigenetics of a virus in terms of time compared to us humans, viruses are us, evolution, nature and memory, and then there’s biology ,virology and gene editing, we can actually tweak epigenetics in our favor, but the virus is faster, mutation, that’s epigenetics in a heart beat, you can’t beat nature, you can work with it, it’s in the genes, memory, fractal memory, does the spike carry the memory of the whole virus, mRNA to the host cell? Your playing epigenetics when you take the vaccine, pay attention to the telomeres, epigenetics 6 Reply 2 replies Mark van der Rijt Mark van der Rijt 1 month ago Thanks for the excellent breakdown. It was very interesting, indeed. I wonder what will happen when ageing becomes reversible. Imagine what would happen to the world's population. Or will the magic only be available for the happy few? Food for thought surely! Keep up the good work! 5 Physionic Reply 3 replies Brian Brian 1 month ago As a 23 year Firefighter/Paramedic, with all the toxins I’m constantly exposed to, along with the lack of consistent sleep, this tells me I’m screwed. Great info to know, though. Thanks for putting this kind of cutting edge material out. It’s very informative and much needed. 7 Physionic Reply Physionic · 12 replies Lois Englund Lois Englund 1 month ago Wow fascinating! Thanks for the breakdown. Love your videos 1 Reply Paul Marganski Paul Marganski 1 month ago I've been taking NMN for a while now. Do you have specific thoughts on this supplement? Reply Kyu-Hun Lee Kyu-Hun Lee 1 month ago This is the first video I've seen from you. Great stuff! Also, I begrudgingly acknowledge your "cell-ves" joke 1 Physionic Reply Physionic · 1 reply Hermes Hermes 1 month ago Fvcking amazing talk! I loved the fact that it didnt end with eating 10kgs of broccoli, but it imparted facts that help me realise how intertwined by behaviour and my health are.. Thanks Doctor 2 Physionic Reply Physionic · 1 reply Peter Ruby Peter Ruby 1 month ago For me, the implication is that the evil powerful people of this world will be here far longer than we can bear. Another thing I noticed - what about the anti-inflammatory drugs role in aging? You didn't list them in your final three points, but they logically slow down the natural, yet unnecessary DNA damage. 2 Physionic Reply Physionic · 2 replies MaxiCat Hnry MaxiCat Hnry 1 month ago Great study, but honestly I would rather age than mess with my 😢dna, I swear by saunas and fasting for maintain a youthful appearance 😢 would you do a natural follow up on aging looking at what I’ve mentioned plus other scientific backed research 🔬 4 Physionic Reply combiner008 combiner008 1 month ago Thank you, Nicolas, one of your best reviews! 4 Physionic Reply Physionic · 1 reply Griffin Brumley Griffin Brumley 1 month ago Thanks for covering this topic and David. 1 Physionic Reply Physionic · 1 reply Jonathon Freelove Jonathon Freelove 1 month ago Brilliant break down of the study mate fascinating stuff Physionic Reply Physionic · 1 reply Re E Re E 1 month ago Linking the study in the bio would be great! 1 Reply The Vigilant Stewards The Vigilant Stewards 1 month ago (edited) Excellent video, sub'd. Great presentation and explanation Physionic Reply Physionic · 1 reply Paulo Sousa Paulo Sousa 1 month ago Fantastic summary. Thanks! 1 Physionic Reply Physionic · 1 reply Robert Rowan Robert Rowan 1 month ago Firstly, Robert Van Winkle would patently beg to differ on the question of coolness, as his alter-ego has much invested in it. That jest aside, do we know why the mice went blind? And if so, was there retinal regeneration. Or were there more simple corneal/lens issues? Either way, not a bid vid overall, well done. Physionic Reply Physionic · 1 reply Minh Bao Tran Minh Bao Tran 1 month ago This has already been explained in Dr. Sinclair's book 14 years ago. Physionic Reply Physionic · 1 reply Richard Breeze Richard Breeze 1 month ago Good job. The thing is Nick the mice still die. You might wanna do a video on the efficacy of NAD + boosters. I'm very skeptical of them. 2 Physionic Reply Physionic · 4 replies abc abc abc abc 10 days ago 400+ videos and I found you today ? Amazed with the horrible YouTube suggestions/algorithm despite searching for health based videos all the time. Physionic Reply Physionic · 2 replies Praveen Sriram Praveen Sriram 1 month ago I just subscribed to your channel after watching this video. I will also try fasting. Thank you so much 😊 Physionic Reply Physionic · 1 reply buybuydandavis buybuydandavis 1 month ago I like the demon possession theory of aging. Implies that all we need to live forever is an exorcist. 3 Physionic Reply TheChocolat Blanc TheChocolat Blanc 1 month ago Thanks I was looking for this kind of video instead of those shorts spitting the title of the article at you and leaving you mostly confused haha. Really great to have more context. Reply valar valar 1 month ago This 44-year-old man with a bad back and knees is cautiously optimistic. IV-therapy NAD+ has really helped me though. 1 Physionic Reply Physionic · 1 reply Venice J Washington Venice J Washington 1 month ago Thank you for the summary! Physionic Reply Physionic · 1 reply matkaGrogan matkaGrogan 1 month ago Also, what about the phenotype of that ICE+OSK mouse(mice)? did they get rid of that grey hair in the slightest? became more sturdy and frisky after applying Y F? 3 Reply CoachDoug714 CoachDoug714 1 month ago Specific actionable takeaways or suggestions would be helpful. Reply matkaGrogan matkaGrogan 1 month ago Anyone knows how these Y T F (Yamanaka transcription factors) work? I mean what do they do, mechanistically? If they remove wrong epigenetic tags and (I assume) add original/healthy/correct ones to a) curb incorrect gene expression b) re-iniciate a robust/right/base gene expression - then- how do "they" (these 3 proteins) know how to do it? I mean how do "they" know which tags are supposed to be corrected? "they" must reach for some kind of a base "template" where that information is being stored... 1 Physionic Reply Physionic · 4 replies Alex Park Alex Park 1 month ago I think I’ve finally found someone with similar humor codes 😂 Physionic Reply Physionic · 1 reply Dick Baan Dick Baan 3 weeks ago A huge part of aging is bluntly said, laziness, lack of exercise doin less and less. the couch and watching tv are silent killers Physionic Reply Matthew Flamini Matthew Flamini 3 weeks ago Not sure why the downregularion of yh2ax means the damage was fixed. Explain maybe, how long is this expressed after DNA damage? Maybe it's only after acute damage but then is downregulated over time. Reply Tanner Christianson Tanner Christianson 3 weeks ago sinclair has me researching constantly in my spare time about longevity. Theres not a TON of things you can do, but ive come to the conclusion that carnivore diet, and exercise is the best thing for now 4 Reply 3 replies Sota Sota 3 weeks ago What anti aging supplements are ineffective? Reply Nick Junes Nick Junes 1 month ago I'd like to see more information on why we can't use the Yamanake factors ourselves? Physionic Reply Physionic · 1 reply AHF AHF 1 month ago Ran into Dr Sinclair while in line for Dinosaur at Animal Kingdom on NYE. 2 Physionic Reply 1 reply Zack 120 Zack 120 1 month ago Since epigenome is just like the executive branch of the US government carrying out the daily jobs, it is not surprise for it to play a role in aging. Reply Primal Instinct Primal Instinct 13 days ago Wonder if this implies that intentionally putting yourself into supposedly repairing "keto" state is a bad idea Reply Thinking Biblically Thinking Biblically 3 weeks ago "The wages of sin is death." That is the cause of aging. Reply Eyes of Ibad Eyes of Ibad 3 weeks ago Are we closer to longevity escape velocity? Reply Jonas G Jonas G 2 weeks ago As a human (I think) I liked this video. Physionic Reply Little Voice Little Voice 1 month ago How's your healthy diet progressing? In 2022, you shared some plans. Will there be a 2023 update? Physionic Reply Physionic · 1 reply Lars Nyström Lars Nyström 1 month ago If Sinclair belives that he can make mice younger. Why does he have to damage them first? Why not just make naturally old mice younger? And if he damage some mice and repair them. Does they live longer than damaged but not repaired mice? 3 Reply 2 replies Hououin Kyouma Hououin Kyouma 1 month ago Ride the spiral till the end, we may just go where no one's been 1 Reply vsaluki R vsaluki R 1 month ago (edited) Frankly, I don't trust Sinclair. And I'm betting that his answer is going to be some product for which he has the patent. 7 Physionic Reply Physionic · 5 replies L L 3 weeks ago What happens if we had many CT scans in our twenties? Does it mean for sure our DNA is damaged. 1 Reply 1 reply Mitesh Patel Mitesh Patel 1 month ago I wonder how Sinclair's papers get past peer review! He's knowledgeable but he just cooks up plausible stories which some may consider scam. 4 Physionic Reply Physionic · 11 replies Bdjshwbwhdhh Bdjshwbwhdhh 1 month ago (edited) Dr Sinclair may have a financial interest in this view being validated because he has a business interest in longevity supplementation. Like all scientific research this should be taken with a pinch of salt until the results have been reproduced by other independent researchers. 1 Reply 1 reply UHFStation1 UHFStation1 10 days ago Good summary of similar videos. Reply applyingChatGPT applyingChatGPT 1 month ago The content was dense but you speak clearly, talk slow, and have a very calm demeanor so it was easy to digest. Awesome video! Physionic Reply Physionic · 1 reply Michael Sebastian Michael Sebastian 1 month ago I almost didn't get the joke "cells" becoming your "youngercells/younger self" at first lol, great joke btw Physionic Reply Physionic · 1 reply Book of Life Book of Life 3 weeks ago Aging seems to be a series of mistakes happening within the body, overload of information, energy and cleansing required to sort and heal. Fasting, reduction of toxicity, reduction of stress, while obtaining energy from sincere sources, for instance the source of energy life maintains being able to produce, do not kill the plant, animal, or being, thus a possible reason the big ass goat/sheep evolved to that point, to show people its possible to obtain life force from the milk, the fat, the moss, the fruit, the herbs, seeds, light, air, water, vibration while allowing life to be. Roses have a beneficial conductive ability however that may be obtained while allowing the rose to live, thus the possible reason of roses with thorns and without thorns, its the electrical capability, the rose petals, the humidity above the rose, the scent, the air. Will man evolve to become a complete breatharian and or capable of harnessing electricity to support life without harming or interfering with life? Are the 120+ minerals we need primarily to charge and align our positive and negative charges to balance each cell and support life force to activate and maintain our innerchi? Reply Matej Ravas Matej Ravas 2 weeks ago i'd say the biggest problem in science of ageing is that people seem to be looking for that one single key cause or holy "knob" to turn it off or even reverse it and seem to be overlooking the possibility of it being managed by a larger file or system of many factors counted in at once.. a system that is only as strong as its weakest part.. something that is very sensitive to all possible aspects of lifestyle as a whole.. maybe everyone who ever thought he found that knob was right but he didn't feel like it because they've all expected their knob to be the master one and they were purely on a quest to find that one, not allowing themselves to be satisfied with anything less while nothing more superior than what they found might not even exist, only more and more of those they already found a lot of.. Physionic Reply Physionic · 1 reply Calvin Jackson Calvin Jackson 2 weeks ago But the bottom line is: can scientists slow or stop the aging process or reverse it. Reply zibtihaj zibtihaj 1 month ago what do Sinclair's critics say about all this.... ? Reply computerhelpcc computerhelpcc 1 month ago awesome review 1 Physionic Reply Physionic · 1 reply Chris Winter Chris Winter 3 weeks ago Did I hear the name of that drug right? It's Tamoxifen? Isn't that an anti-cancer drug? Reply chuck duck chuck duck 2 weeks ago that was good , but we need an up date, on his book, I was hoping for more info. so far there has not been enough info of the influence of excerice and the interaction of the eppgentic system, and sirutins ,revitalization, ie muscle development influence on the systems, and protein, the mice ran there ass off ....and so do I....(bike ride)....and whats is now the roll of Revertrol Reply Perry Stevens Perry Stevens 1 month ago Is this regarding cell DNA or mitochondrial DNA? Physionic Reply Physionic · 1 reply petar mitic petar mitic 3 weeks ago Conclusion was the only thing I managed to follow n I did not hear anything new, eat healthy, exercise and don‘t smoke 😂 Reply Dadson worldwide Dadson worldwide 1 month ago (edited) I'm not sure when abomination occurs its a grey area. A fine line! Reply Ramon Oliveira Ramon Oliveira 3 weeks ago In the future, aging will be a thing of the past. Reply jj jj jj jj 1 month ago so dna damage could be the reason why we age ? Reply Daniel Gutierrez Daniel Gutierrez 1 month ago CHF 1.00 Thanks! 1 Physionic Reply Vincent171090 Vincent171090 1 month ago Loved the humor :D Physionic Reply Physionic · 2 replies Ken Bell Ken Bell 3 weeks ago So my take away is eat well get plenty of exercise and sleep and avoid toxins and radiation Physionic Reply Jason CHU Jason CHU 1 month ago Great ! Physionic Reply LucYfYre Arch of TwiLight LucYfYre Arch of TwiLight 1 month ago Fascinating. Physionic Reply dbzwarrior4321 dbzwarrior4321 3 weeks ago Sooo could this bring back our baby faces? Reply Gonzalo De La Maza Mendizabal Gonzalo De La Maza Mendizabal 1 month ago Interesting, I dont think there is a lot of strong evidence towards the accumulation of mutations contributing significantly to aging. Physionic Reply Physionic · 1 reply Jean-Pierre Dalles Jean-Pierre Dalles 1 month ago is there a traduction somewhere ? Reply sudd sudd 1 month ago in the end, some want to sell you something. that is never about health. Reply [biosecure] [biosecure] 1 month ago Don't listen to Sinclair, listen to Prof. Khavinson. 1 Reply Παναγιωτης Αγγελ Παναγιωτης Αγγελ 1 month ago David Sinclair state that we won't reverse our biology age but reverse some deceases that are connected with the age. Reply Juliat Shamoun Juliat Shamoun 1 month ago (edited) 😴 Have so many questions about Dr. Sanclair product about anti-aging The NAD and NMN ... Natural Factors supplement company in Canada has the 1st product approved with NPN # (natural products registering number) approved by Canadian government The product are very very expensive??? Who will buy it like $ 225 per product 🙄 Reply 3 replies asd fom asd fom 1 month ago we will live for ever Reply Kyle Kyle 1 month ago (edited) So it's not telomere shortening that ages you anymore? 1 Reply 1 reply Robert Gipson Robert Gipson 1 month ago Exceptionally clear.l 1 Physionic Reply Physionic · 1 reply Simon Long Simon Long 1 month ago Is this the NMN stuff or newer than 3 years ago? Reply Robin Hood Robin Hood 1 month ago No 'theories' necessary when 'ageing accelerators' are being used! Reply Qey Shinkurt Qey Shinkurt 1 month ago Hahha so this actually works? Reply rico dyson rico dyson 1 month ago 10:48 Got it! Physionic Reply Physionic · 1 reply Steven Lucks Steven Lucks 13 days ago Did NMN do the same thing? Reply Christopher Ellis Christopher Ellis 1 month ago Stopped listening to him when he went over to the Dark Side and stopped eating real food. Physionic Reply Subtronik Subtronik 1 month ago Why the obsession with takeaways? What happened to conclusions? 1 Reply Celestial Moon Celestial Moon 1 month ago Fasting is still the best and most effective Natural anti aging tool .. 1 Reply 1 reply Rui Nunes Rui Nunes 1 month ago The Anunaki created us with they long longevity genetic legacy, but changed it scared about their oen creation 1 Reply Steven Green Steven Green 1 month ago Brother has a Gordon Freeman vibe going on, need the gotee though. Physionic Reply Physionic · 1 reply Doug G Doug G 3 weeks ago Everything grows old and dies. It’s supposed to happen Reply Santa Santa 1 month ago Soilent green is Ppol! 1 Reply Marcus Diaz Marcus Diaz 13 days ago Look I'm not the sharpest tool in the shed but any progress will be for the super-rich. However,us grunts should be worrying about one of those super mice escaping n causing some shit 😒 Reply Crypto Kids Crypto Kids 1 month ago Btw, Vanilla ice is cool Physionic Reply iv3nomousi iv3nomousi 3 weeks ago So you would advise that I not eat 2lbs of Uranium each day? Physionic Reply Physionic · 2 replies Saul W Saul W 1 month ago Watch video on 1.5x speed your welcome Reply hearv hearv 1 month ago Sinclair is a known scammer, so take it with a grain of salt. He’s just getting ready to sell a new company based on false data. 1 Reply Physionic · 2 replies HunkyDoryWho? HunkyDoryWho? 3 weeks ago Demons?? Was the exorcist part of the study??🤨🤨 Physionic Reply Physionic · 2 replies CatVsBobcat CatVsBobcat 10 days ago Are you related to Dr. Mike? 1 Physionic Reply Physionic · 1 reply Nick Scoli Nick Scoli 1 month ago DNA methylation and epigenetic aging is not a new theory. Physionic Reply Physionic · 2 replies it's me Yamenah it's me Yamenah 1 month ago We're Muslims we know this already 1400 years ago, fasting makes new cells or eat less there are also recommended food to eat anyway... Reply John Hancock John Hancock 1 month ago sounds like, from the title, you are just tryingb to cash in on Dr Sinclairs good name Reply Physionic · 1 reply Age-reversing' supplements: What NMN, TMG and berberine did for us The Honest Channel 33.8K subscribers Subscribe 1.3K Share 42,950 views Feb 19, 2023 #nmn #antiaging #agereversal In this week's video I share the early results of taking NMN, TMG and berberine together with my parents for one month - and whether we intend to keep going with this anti-aging regime, recommended by Dr Elena Seranova of NMN Bio. We also discuss safety, and the powerful effects of taking this as a supplements combo, with berberine one of the most exciting natural solutions to supporting blood sugar levels. #agereversal #antiaging #nmn Subscribe to my channel here https://www.youtube.com/c/TheHonestCh... Find out more about NMN Bio's supplements, with a 10% discount included using this link: https://nmnbio.co.uk/discount/ClareJ Discount code is ClareJ NR alternative to NMN, TruNiagen https://amzn.to/3IfAaD9 My first interview with Dr Elena • Is NMN the 'longe... FURTHER READING The Glucose Revolution by Jesse Inchauspe https://amzn.to/3XEXVKF Why We Get Sick by Benjamin Bikman https://amzn.to/3EgaoNV Healthline articles on berberine's potential https://www.healthline.com/nutrition/... and NMN https://www.healthline.com/health/nmn... You can find links and, where possible, discount codes for some of my favourite anti-aging and beauty products at https://go.shopmy.us/TheHonestChannel I use affiliate links on this channel which means if you choose to buy a product using one of my links I receive a small commission - thank you! : ) This video is not sponsored. You can find my commercial policy here https://www.youtube.com/@TheHonestCha... TIMESTAMPS 00:00 Intro 02:23 Why combine NMN with TMG and berberine? 06:38 Insulin resistance and age-related disease 12:12 NMN safety 18:29 What kind of results can you expect? 23:35 Our experience Connect with me on social media: https://www.instagram.com/honestclare https://twitter.com/ClareS_J https://www.facebook.com/honestclare/ Edited by David at https://www.redfacilities.com Disclaimer: This video and all content on this channel is for informational purposes only and is not intended as medical advice and should not be treated as a substitute for medical advice. Chapters View all License Creative Commons Attribution license (reuse allowed) 241 Comments rongmaw lin Add a comment... Nichola Blakely Nichola Blakely 1 month ago I’ve been taking nmn 450mg for a month and I noticed a spike in my energy straight away, work outs are much more enjoyable, deep sleep and dreams, skin is noticeably softer (I am 54)… went to a function with friends and family recently and two people asked what I was doing as I look younger! So I am hooked, I believe incorporating daily exercise and good nutrition is part of this as they help to generate the effects even more. The Pulse is a good Chanel to follow on this subject. 34 The Honest Channel Reply The Honest Channel · 3 replies Connie H Connie H 3 weeks ago Please can you discuss the role of NMN in rescuing female fertility on the next one? I know there's not much research into this area as yet, but despite the impact on reversing ageing on mouse fertility, it's being ignored atm. If men had menopause I'm sure it would be a different story! I'm taking NMN in the hope it reverses menopause temporarily and boosts my egg health. I'm also taking tmg and several other fertility boosters. I'm on a low carb diet too to reverse insulin resistance. Btw are you aware of the FDA ban on NMN as a supplement in the USA? Apparently it's being withdrawn from USA shelves on March 13th and recategorised as a drug. Not sure what that means for NMN takers in the UK as yet despite reassurances from various companies. I'm following a GP who's wife had her menopause reversed on NMN. The current research shows the ideal dose of NMN is 600mg daily and powder is usually cheaper than capsules. You can Google the info on dosage/trials etc. The info is on YouTube too. I also follow a channel called My NMN Experiment which posts lots of NMN studies that you might find useful. 250mg seems a very low dose to me but as you know it is an expensive supplement. You might want to add Apigenin or dried parsley or celery seed to your protocols to lower your CD38 levels to get the most from your NMN (CD38 increases with age and it lowers NAD). I hope it helps your parents. My dad has prostate cancer and I had a thyroid issue myself that I healed myself whilst reducing thyroxine, against medical advice....gradually! Not suggesting anyone should follow my example, but it can be done if you heal your body. 21 Reply 4 replies Melissa Clark Melissa Clark 1 month ago Thanks for the info! I've recently come across Pycnogenol and am starting to take it. I've read some amazing benefits, like it increases hyaluronic acid levels in the skin up to 40%! It also helps with blood circulation. Keeping the blood vessels on the face healthy and living is important to aging gracefully. 14 Reply The Honest Channel · 18 replies Eileen Brown Eileen Brown 1 month ago Very useful information especially when there are so many doctors promoting their supplements & diets! Hard to know which is best & right for one or what may be just hype. Thank you for investigative reporting! PS. Maybe your father may want to try the red light therapy on his feet for his arthritis to see if it may help as well? 1 Reply The Honest Channel · 1 reply SJB SJB 12 days ago I’ve been taking NMN for about three weeks and the first week was terrible. No energy, tired, sluggish- week three it’s finally got better! I feel rested in the morning, got energy during the day and im not wiped out after the day at night. It’s not the big burst I keep hearing about more a steady and consistent energy. 2 The Honest Channel Reply The Honest Channel · 5 replies Dean Ervik Dean Ervik 2 weeks ago I take 500mg of NMN (based on human trials results) on Wednesday and Saturday mornings hours before eating my first meal at noon. Also I take resveratrol after dinner on Wednesday and Sundays, especially if there’s oils or fats in the meal. I was 56 when I started 4 years ago, feeling great so far, hair seems to have stopped greying 🤞 6 The Honest Channel Reply The Honest Channel · 2 replies GMA GMA 1 month ago (edited) I agree that current research, in nutrition, shows that low glycemic index diets are beneficial, but I wouldn't, personally, try the carnivore lifestyle. There are so many antioxidants and fibers in whole grains, fruits and vegetables that both reduce cancer risk and support gut microbiome diversity. Nevertheless, this was a fascinating discussion and I just love the exploration of different ideas in emerging research on your channel! Very interesting topic! 16 The Honest Channel Reply The Honest Channel · 1 reply Linda Joy Linda Joy 1 month ago Thank you Clare for your investigative interviews. My understanding is to take resveratrol with NMN, this is the advice I have heard from scientists studying the area of epigenetics without direct monetary gain from marketing their own supplements. Do you have any info or thoughts on this? 3 Reply The Honest Channel · 7 replies Anja X TV Anja X TV 10 days ago Oh dear...I've been taking nmn for a about a month now during dinner 😳😳 I've been confused as to why I can't sleep at night. Literally an hour ago my friend asked me how my sleep has been and i said i have to take sleeping pills to even sleep a few hours. Ive always slept 9 hours a night. THANK YOU for this interview ❤️💛💕!! 1 The Honest Channel Reply The Honest Channel · 1 reply Toune Chareunsouk Toune Chareunsouk 3 weeks ago People said take NMN first thing in the morning, empty stomach. But I have to take my thyroid pills, first thing in the morning too. So can you suggest, which one I should take first? Thanks! (I'm in the process of ordering what you suggested. Hope it really work!) 🎉 4 Reply The Honest Channel · 1 reply Claudia Glows Claudia Glows 1 month ago Another great interview! Thank you Clare 7 The Honest Channel Reply Aaron Kitching Aaron Kitching 3 weeks ago This video caught my attention because these are 3 out of the 4 supplements I take. The fourth is Cod Liver Oil. 7 Reply The Honest Channel · 1 reply Hello Nil Hello Nil 8 days ago I have had bought Berberine and lost since then I taking them a few pounds ! Very pleased about it ! Thank you :)👍👍🌹🌹 The Honest Channel Reply White Ninja White Ninja 2 weeks ago Just bumped into this channel today. Wow, what a beautiful lady the host is--both inside and out. Ran another quick video here and liked that one, as well. Been in the health industry for 25 years now and still learning something new every day. Very exciting field of study! Lord bless! 2 The Honest Channel Reply The Honest Channel · 1 reply RusaForever RusaForever 1 month ago If your mom has a Thyroid problem, I'm seeing it's hypothyroid or diminished Thyroid activity in response to normal or high levels of TSH production, I would suggest she take selenium daily. Not overdosing, but just taking the standard dosage but making it a daily habit. Copper and zinc are also helpful in helping to maximize Thyroid hormone activity. This is something NMN is not so effective for. 8 The Honest Channel Reply The Honest Channel · 3 replies Dor Isarn Dor Isarn 2 weeks ago Are there any contraindications or drugs/ foods ( i don't mean processed or unhealthy items) to avoid when taking NMN? Reply The Honest Channel · 1 reply kay-ash kay-ash 1 month ago i wonder if there is also an element of a placebo effect on yourself and your parents. drug studies often report something like 30% improvement of symptoms in placebo groups (versus maybe like 70-80% improvement of whatever the actual drug is) 4 Reply The Honest Channel · 2 replies Heidi Kamrath Heidi Kamrath 1 month ago Clare, with all this talk about blood glucose levels, have you considered wearing a continuous glucose monitor for a few weeks to actually track it? There are several on the market. Levels comes to mind. Zoe offers one as well if you agree to be in their study/ies. I just think, rather than say you “feel” like your blood glucose is this or that, it would be more convincing if you know. 9 Reply The Honest Channel · 1 reply CC CC 2 weeks ago (edited) I really wish this channel would feature guests who don't have a commercial motive. I take NMN/NR, but I get my information from credentialed sources (reputable MDs and PhDs) who aren't selling the supplements. Same with cosmetic products and devices. It's just more credible to rely on evidence-based research and get information from people who aren't promoting their products. 3 Reply 1 reply Dre Howard Dre Howard 1 month ago I like supplements, but EVERYONE should read "Fast and grow young". Our bodies are incredible miraculous creations with the ability to heal itself! All of todays "Dis-eases" are created by our diet. Our food lacks the nutrition it once had, and even 'organic food' has toxins from the soil. Fasting has long been doen throughout many cultures, and even animals instinctively 'fast' when they're sick. The book is fabulous and very eye opening. 34 Reply The Honest Channel · 3 replies Chieh Wu Chieh Wu 3 weeks ago (edited) Please run an nad test as soon as possible. Ideally you would run the test before the supplements, but you should do it soon to keep track of the progress. At your age your nad level should be at half of a teenager, so if you take the test now you can compare against that. I would be very interested i hearing your results. Also, you want to consider taking a biological age test, your biological age should decrease as you take NMN and TMG. If you take that test also please share your results. 5 Reply 1 reply Βικτωρια Γιαλυρη Βικτωρια Γιαλυρη 1 month ago I just started watching. I have taken all 3 of these supplements for 6 months and to be ownest with you i noticed no difference. That's why i stopped. Have a great evening!! 13 Reply The Honest Channel · 5 replies Jo Ann Smith Jo Ann Smith 7 days ago I feel much better, don’t need an Afternoon nap any more, more stamina but I do notice that I’m NOT sleeping as well and I’m only taking 250 mgs Reply Aldo Matulich Aldo Matulich 3 weeks ago Frankly, I'm on INFO Overload. I have Spinal Arthritis which generates daily Chronic pains and Terrible stiffness affecting my entire Body and Psyche. I take far too many supplements ....the list is long but does include Berberine, Turmeric, Ginger, Cinnamon, Bromelian, Zinc, Ds, Cs, Es, Mgs, K2s (with D3s). Wish I could say there is improvement. No Can do. Just had 3 recent MRIs done (Cervical, Thoracic, and Lumbar), the arthritis, the Disc Degeneration, sites of stenosis continue to increase. These conditions have been experienced for decades having started in the Lumbar Spine /Hips/SI joints and Transgressed up the spine to the top of my head. So, I seek "MAGIC" (there is no Surgery to help me per 6 surgical Consults). Like BIG PHARMA, I am increasingly leary to puruse even more Supplements (They are expensive too). I'd love to see what this doctor recommends. THX for your time to make this video. 1 Reply 2 replies nick christopherson nick christopherson 8 days ago If you can exercise u do not need to take berberine..in fact it attenuates the stress it puts on u and lessens your vo2 max...plus it was just found out that when NMN goes through the liver porthole it is changed to nicotinic acid..you are better using nicotinic acid that is a fraction of the cost and it does support the nad salvage pathway Reply The Honest Channel · 1 reply susy may susy may 3 weeks ago Your timestamps really accentuate your nice videos! 👍 Reply RusaForever RusaForever 1 month ago It's a very interesting talk. I'm wondering, she mentioned the carnivore diet and I just have seen opposing data to the health effects of that diet. First of all, you have the production of AGEs, you have the production of TMAO by gut bacteria in meat eaters that leads to cancer and heart disease. Next, you have data showing the efficacy of the vegan diet in reversing aging. Bryan Johnson is a perfect example. He takes epigenetic tests to see changes in his biological age in response to everything he eats, and he says the prime diet is veggies, nuts and fruit. He has invested millions into optimizing his diet.He is vegan and he got that way because of the tests he has done on himself showing that meat is not a good option for someone looking to reverse aging. There is an insulin connection, there is a lot to do with blood sugar, but she's not differentiating simple vs complex carbs. Simple sugar is toxic to the liver, and should be avoided at all costs. Complex carbs are not going to cause the same blood sugar effects and there is more to it than just avoiding carbs. Meat is high in protein, which negatively affects the sirtuin pathways and leads to accelerated aging. Low protein according to Dr. Sinclair is the best option for reversing aging so that fact goes contrary to what has been said in this video. Berberine is also great but why are we avoiding mentioning the elephant in the room, ALA, Alpha lipoic acid, which has been shown to reverse cancer and not only stabilizing blood sugar but actually eliminating diabetes and reversing peripheral neuropathies in diabetic patients? And it's better than berberine, which is a weak form of metformin. ALA has been shown to work better than metformin. It would be nice to hear her thoughts on these subjects because the data shows the carnivore diet is not a good option and I'm very surprised to hear that. Hormonal optimization too is interesting to me because I for one have an hour glass figure and no visceral fat and I'm eating a vegan diet which is higher in complex carbs and fats and low in protein and so this idea that somehow carbs will cause this increase in visceral fat is untrue to me. It's true for simple carbs only. 11 Reply The Honest Channel · 2 replies Cozmicsuga Cozmicsuga 3 weeks ago Thanks you for sharing all this info. 1 Reply Joe McMeekin Joe McMeekin 3 weeks ago I subbed, you asked great questions. Thank you ! The Honest Channel Reply The Honest Channel · 1 reply martha nguyen martha nguyen 3 weeks ago I love your videos! Can you talk about "Nira PRO laser" only sold in England. And "AMIRO" skin device. Thanks! Reply Andrew Ward Andrew Ward 3 weeks ago Since I started taking NMN I do seem to get up more frequently during the night (67 years old). It could be my imagination. 3 Reply 4 replies Donna Donna 1 month ago What is the suggested dose of Berberine per day? 1 Reply The Honest Channel · 1 reply Santana Caipirinha Santana Caipirinha 1 month ago I tried this for a few years, different doses, premium quality products. No results whatsoever. It was worth a try, but a hit to my bank account. 5 Reply The Honest Channel · 3 replies Eden Posh Eden Posh 1 month ago thank you for another interesting video:) The Honest Channel Reply The Honest Channel · 1 reply Hope Springs Hope Springs 1 month ago (edited) In March 2022, I decided that I was sick of being 16st. I did these things 1. Cut out sugar 2. Cut out carbs 3. Began a carnivore OMAD LIFESTYLE!!!!!! This is not a diet it is a life choice. I am now a healthy 10st. ( Though BMI said I should be 7.5st. Ermmmm no way I would look terrible🥹) I take NMN and TMG as-well as other supplements. At 60 I feel better than I did at 30. I have energy confidence and a new zest for life. PS Love the channel ❤ 25 Reply 7 replies L R L R 1 month ago (edited) The answer to the question about these supplements feeding cancer did not address the actual problem. Of course, doctors will not give these supplements to someone diagnosed with cancer. The issue is, taking these supplements BEFORE knowing of cancer diagnosis and unknowingly feeding cancer by taking these supplements. Would be ideal to have this addressed. 12 Reply 2 replies juliana mejia juliana mejia 2 weeks ago I’m 24 , can I take NMN supplements for reverse anti-aging. Thank you 😊 Reply 2 replies Bernadette Becher Bernadette Becher 3 weeks ago DrBeen did a recent podcast on Berberine- very in-depth. 1 Reply Creighton Freeman Creighton Freeman 3 weeks ago In 1982 Pearson & Shaw in "Life Extension, A practical scientific approach" suggested caution in abruptly stopping megadoses of water soluble vitamins because of the potential of causing symptoms of vitamin deficiency if cells and tissues acclimated to high levels of vitamins are suddenly deprived of them. For this reason I doubt that "cycling" a water soluble co-enzyme like NMN is a good idea, at least not without a gradual taper off the dosage over a period of two or three weeks. For the same reasons Dr. Seranova recommends ramping up dosage when starting a new supplement, when quitting I think it advisable to ramp down the dosage over time as well. Cells seek to maintain Homeostasis, and abrupt changes mess with that. Reply LQ LQ 3 weeks ago She is riding on the coattails of Sinclair while selling the supplements he recommends. Berberine is a non script alternative to Sinclair's darling, metformin. 4 Reply General Bystander General Bystander 3 weeks ago The good doctor doesn’t seem to know too much 2 Reply 1 reply Lisa Falanga Lisa Falanga 3 weeks ago Is it just the USA where you cannot purchase NMN anymore? I heard that our FDA is banning it…OTC or otherwise..Thinking this is the case..🤓 3 Reply 5 replies Gail Koelmeyer Gail Koelmeyer 2 weeks ago I had just bought NAD Plus, just took two capsules before seeing this podcast after which I didn't feel too well, infact i felt awful..so i stoppped. Reply The Honest Channel · 1 reply Mary Nasiem Mary Nasiem 3 weeks ago I agree on the dreams!! Reply Ranghashal Atr Ranghashal Atr 11 days ago Is it avilable on market Reply Jon Cross Jon Cross 6 days ago I want to contact your guests basically see if help stroke recovery with supplements Reply Philly3458 Philly3458 3 weeks ago Doesn’t berberrine inhibit lean mass muscle development 3 Reply Rosie Foster Rosie Foster 4 days ago Maybe you could ask someone to give their option that does not aim to make a financial gain from selling their own product, an unbiased review . Reply Cathy Kirton Cathy Kirton 1 day ago Sinclair research! Reply Ros Mac Giolla Mhuir Ros Mac Giolla Mhuir 9 days ago Hello, have you looked into Gary Brecka and the 10x genetics testing?? Reply Bfndlsl Cbdns Bfndlsl Cbdns 2 weeks ago I just wana look younger and have thicker hair again :( at 31 I feel that I look significantly older than I did even at 28. Makes me sad and scared at how I’ll look in a year, two, three Reply The Honest Channel · 1 reply Denise Schoenberger Denise Schoenberger 3 weeks ago Is this available in Canada? 1 Reply 1 reply terry tari terry tari 2 days ago Honest: I will take your vitamins so I can have a pretty lady like you! Reply Sadiqa Khan Sadiqa Khan 1 month ago Thanks for doing this video dear. 1 The Honest Channel Reply jamie souza jamie souza 1 month ago What about the decision to take NMN off the market? 1 Reply The Honest Channel · 1 reply Mac Fiach Mac Fiach 1 month ago Do Berberine and Metformin do the same thing? 1 Reply 2 replies Fosse Fosse 3 weeks ago You should take trans-Resveratrol with the nmn. 2 Reply 1 reply Moi Suir Moi Suir 2 weeks ago Hi what about sirt 6, reservatol and spermidine Reply IbadassI IbadassI 3 weeks ago Why can't I just take vitamin B complex tablets that have all the B vitamins in it as an alternative? Reply 2 replies martha nguyen martha nguyen 3 weeks ago Super Oxido of Dismutase tablets Is true works like anti-aging? 2 Reply 1 reply Eden Posh Eden Posh 1 month ago then before taking NMN I have to check myself for cancer??? 5 Reply Ranghashal Atr Ranghashal Atr 8 days ago When I contact for longevity madisine in nepal Reply Paul Hartman Paul Hartman 9 days ago Berberine is what people take when they can't get metformin, correct me if I'm wrong. Reply 1 reply Fran Fran 7 days ago I stopped taking nmn as I was worried about the cancer risk? Reply The Honest Channel · 1 reply elizabeth Schmidt elizabeth Schmidt 7 days ago Is this only for Female ?? Reply The Honest Channel · 1 reply william moor william moor 1 month ago Dr. Barry Sears wrote Enter The Zone in 1995. Read it and save yourself thousands of dollars. 1 Reply Joeni Snapje Joeni Snapje 12 days ago Doesn’t NMN cause cancer? Reply The Honest Channel · 1 reply Nico Effem Nico Effem 3 weeks ago one month is not really long enough.. Reply Jack Seneca Jack Seneca 3 weeks ago Alas, I am 7 months late 4 this giveaway. Thanks 4 introducing the item anyways. Reply Deb Thib Deb Thib 1 month ago Could you pleases interview Dr William Li EatTo Beat disease 4 Reply Patrick Ticman Patrick Ticman 1 month ago All anecdotal. Please post citations on a human RCT to validate your claim. 1 Reply Master J Story Master J Story 5 days ago THEY DON'T WORK !! Reply Sahin Habesoglu Sahin Habesoglu 2 days ago just eat the plants instead of wasting money on those things and risking adverse effects Reply Josipa G Josipa G 3 weeks ago You are taking too much stuff and you and your followers will never know which did what, and it is hardly be helpful to population on large scale, it is too confusing, and maybe things due to interactions can improve but also worsen things. 2 Reply The Honest Channel · 1 reply Ranghashal Atr Ranghashal Atr 5 days ago Its all are fake if its true then why not come on market Reply Green Earth Green Earth 1 month ago Carnivore diet, oh my 😮‍💨Sorry, but I really hope you weren't serious when you said you will invite her again for an interview on diet. 12 Reply 8 replies Iceprincess one Iceprincess one 1 month ago Ah - she has direct money gain and interest in selling and advertising this product (do you get them for free?) . Thanks but no thanks. When a scientist with no personal gain tells us this product is worth taking I will listen. Thanks for the effort though. 14 Reply 9 replies Green Earth Green Earth 1 month ago It's not transparent when comments that are questioning the diet of your interview guest are being deleted 2 Reply The Honest Channel · 2 replies Heidi Kamrath Heidi Kamrath 1 month ago Carnivore = no fiber. And she thinks that’s healthy?? 10 Reply 9 replies joseph dirnfeld joseph dirnfeld 3 weeks ago (edited) Snake oil of the month Bad theory leads to bad practice 1 Reply Connie Tee Connie Tee 1 month ago Carnivore diet! Nuff said! 😮 2 Reply You know You know 3 weeks ago (edited) NAD is linked to cancel. Do your research Reply The Honest Channel · 1 reply 6 replies