Autophagy ; Yoshinori Ohsumi ; A One-Day Starvation Secret Got the Nobel Prize

A One-Day Starvation Secret Got the Nobel Prize BRIGHT SIDE 44.4M subscribers Join Subscribe 58K Share 2,215,468 views Jan 22, 2019 You probably know that most tissues in your body regularly replace their cells with new ones. Different organs need their own time to renew completely. And some tissues don't replace their cells at all. But have you ever wondered where the dead cells of your body end up? Dr. , a Japanese cell biologist, spent years studying how human cells get rid of their waste. If this process in the body doesn't work correctly, a person can develop type 2 diabetes, Parkinson's disease, some age-related diseases, and even cancer. And it turned out that when you fast, your cells live longer and produce more energy! Other videos you might like: I Drank Only Water for 20 Days, See What Happened to My Body • I Drank Only Wate... What Will Happen If You Eat Nothing for 7 Days • What Will Happen ... I Ate One Meal a Day For a Month, See What Happened to Me • I Ate Once a Day ... TIMESTAMPS: What autophagy is 1:07 What biochemist Dr. Christian de Duve discovered in the 1960s 1:41 Do you need to eat animal protein to build new cells? 2:33 Whan autophagy gets more intensive 4:16 The health benefits of intermittent fasting 5:16 A 24-hour fast 5:58 Fasting on alternate days 6:17 Skipping meals 6:55 Daily-window fasting 7:17 Water fasting 7:52 Why it’s good for you to have animal-protein-free days from time to time 8:09 Preview photo credit: Nobel laureate Yoshinori Ohsumi shows his medal after an award ceremony in Stockholm on Dec. 10, 2016. Ohsumi was awarded the Nobel prize in physiology or medicine for elucidating "autophagy," an intracellular process that degrades and recycles proteins: By Kyodo/Associated Press/East News, https://www.eastnews.ru/pictures/pict... Animation is created by Bright Side. Music by Epidemic Sound https://www.epidemicsound.com/ SUMMARY: - The first person who discovered autophagy was Belgian biochemist Dr. Christian de Duve. For this discovery, he got the Nobel Prize in Physiology or Medicine in 1974. - Surprisingly, studies show that they still have approximately the same amount of proteins and carbohydrates in their digestive system as they would if they ate animal protein. - The body can use its own protein in the form of dead and damaged cells and bacteria which have been previously stored away. - If your natural recycling mechanism doesn't work, damaged cells and their parts start to accumulate in the body. And it ends up unable to neutralize cancer cells and cells infected by dangerous viruses and bacteria. As a result, this can lead to various serious illnesses. - Dr. Yoshinori Ohsumi found out that autophagy gets more intensive when the body is undergoing some stress. Such stress can be fasting, calorie restriction, or even starvation. - In all his studies, Dr. Yoshinori Ohsumi used starvation and fasting to encourage the body to break down toxic cells and get rid of all the garbage. - Intermittent fasting, which is alternating the periods of eating and fasting, can help your body to clean itself. Besides, it can help you to lose weight and speed up your metabolism. - If you're a newbie in the world of fasting and the practice looks a bit intimidating, start with skipping your meals. In general, it's enough to skip one meal a day to boost your metabolism and trigger cleansing processes in your body. Just remember that if you've skipped a meal, you shouldn't overeat at the next one. - One more interesting conclusion you can draw from this research is that, despite what some people think, vegetarians don't suffer from a lack of animal protein. They just get it in a different way. Subscribe to Bright Side : https://goo.gl/rQTJZz ---------------------------------------------------------------------------------------- Our Social Media: Facebook: https://www.facebook.com/brightside/ Instagram: https://www.instagram.com/brightgram/ 5-Minute Crafts Youtube: https://www.goo.gl/8JVmuC Photos: https://www.depositphotos.com East News ---------------------------------------------------------------------------------------- For more videos and articles visit: http://www.brightside.me/ Key moments View all 3,687 Comments rongmaw lin Add a comment... KenDBerryMD KenDBerryMD 3 years ago Fasting is an incredibly powerful health hack that can literally save your life! 561 Reply 30 replies Omar Piane Omar Piane 3 years ago 2 years ago i did 3 months intermittent fasting along with low /zero carb , I had unbelievable results. My mother couldn’t almost recognize me. Look younger, much stronger, lost weight and increased muscles, didn’t need to sleep more than 5/6 hours a day. I felt like a Superman. I am going back to that style again now. 207 Reply 14 replies Frederico Severgnini Frederico Severgnini 3 years ago For those considering to start a fasting lifestyle: I have began this journey myself 2 years ago, and I found out that adhering to a low carb diet significantly reduced how often I felt hungry, making the whole fasting thing far easier to accomplish. At least to me, eating refined carbs (flour, sugar, fructose) increase my appetite a lot and makes me crave for food really hard. 59 Reply 2 replies Mudug Poly Clinic & Neurology Center Mudug Poly Clinic & Neurology Center 1 month ago i'm on day 5 of fasting. the first day is the hardest to get in my opinion and then it's still tough to keep up until day 3. ive done fasting before and i've survived a 14 day water fast. it's probably easier if you live alone, because you don't have to see others eat or smell the food. for me i have a big family in a small house, but i still do it by staying out of the kitchen and not looking at the food. i hope everyone trying to do a fast can get some motivation from this. 16 Reply Sun II Sun II 3 years ago I started fasting many years ago when I was working on my Ph.D. dissertation, and was delighted to find how agile and nimble my mind became when my stomach was empty for a sustained period of time. Thank you for this awesome inspiring video 59 Reply Kenny Starfighter Kenny Starfighter 3 years ago It's really facinating! It means we can save money by not eating for periods of time and also heal us. Thank you Dr. Yoshinori Ohsumi :) 21 Reply 1 reply BRIGHT SIDE BRIGHT SIDE 4 years ago TIMESTAMPS: What autophagy is 1:07 What biochemist Dr. Christian de Duve discovered in the 1960s 1:41 Do you need to eat animal protein to build new cells? 2:33 Whan autophagy gets more intensive 4:16 The health benefits of intermittent fasting 5:16 A 24-hour fast 5:58 Fasting on alternate days 6:17 Skipping meals 6:55 Daily-window fasting 7:17 Water fasting 7:52 Why it’s good for you to have animal-protein-free days from time to time 8:09 29 Reply 4 replies pjr1525 pjr1525 3 years ago By inclination I've only eaten one full meal a day for most of my adult life. I'm 68 and I am the same weight as when I married 44 years ago with no health problems. 287 Reply 12 replies Randy Dookheran Randy Dookheran 2 months ago I do a 36 hr water fasting twice per month (every Ekadashi period in the Hindu calendar). All other days I practice the 16/8 window fast where I eat during an 8hr window and fast for 16 hours. I never eat 4 hours before bed time, so bed time being 10PM, my last meal is at 6PM. 23 Reply 3 replies E V E V 3 years ago Watching this while having the first day of fasting in my entire life! Being chubby/overweight most of my life, I never thought it was possible, until I heard about it's benefits and now reading Dr Jason Fung's book. it should help me end up with my insulin resistance and sugar-dependency. I'm confident it will work :-) 54 Reply 5 replies Nangmo Marceline Nangmo Marceline 3 years ago Am on intermittent fasting now and sincerely it's a Miracle .I have lost weight and I have become more focused and my intelligence has improved . I have become very positive and I don't get angry much 109 Reply 1 reply khaled TARHOUNI khaled TARHOUNI 3 years ago I practice intermittent fasting. I went from 240 lbs to 134 lbs. I have never felt good in my life as today. 752 Reply 43 replies Wiolant SunGazer Wiolant SunGazer 4 years ago 1/4 of what you eat keeps you alive, 3/4 of what you eat keeps your doctor alive ~ Ancient Egyptian Proverb 2.1K Reply 47 replies Zett76 Zett76 3 years ago One-Day-Starvation... what a funny word creation. Shows how wrong we are in our perception of nutrition habits. One day without eating is a lot of things, but surely not starvation. 😁 633 Reply 20 replies Tommy Huynh t_wrex_mtb Tommy Huynh t_wrex_mtb 3 years ago Great video! I have been eating One Meal A Day (OMAD) for almost 2 years (22 months). I lost a 31 pounds in the first 3 months and I have kept it off ever since. I started at 176 pounds and now I weigh 145 pounds. My waist went from 34" down to only 28". It was the best thing that I have done for myself. I own a restaurant and I share my experience with as many people as I can. I have hit my goal weight so I don't do OMAD to lose weight, I do it for autophagy. I feel and look better than I did when I was 21. I get so many people who want to debate with thinking that I'm starving myself. They have no idea what autophagy is. The next person who wants to debate with me I will send them a link to this video. 17 Reply 4 replies Cosmic Flow Cosmic Flow 4 years ago Finally a reason NOT to eat protein! I've been vegan for many years and so tired hearing "you need protein". During the years when I didn't care about protein intake (I like many kinds of veggies, but not so hot on legumes), my protein level from the physical exams was ALWAYS fine all those years. Nobody suspected I was vegan. That's when I thought maybe I just didn't need to eat that much protein. However, during the recent months, I started working out so I made an effort to eat more legumes. Then my body start feeling wrong. More minor health issues like skin condition, joint pain, constipation. Thank you for posting this video! Now I stop forcing myself to eat protein! 7 Reply 1 reply jRex918 jRex918 3 years ago There is no reason to eat 3 times a day. I used to eat 3 times a day and i felt like crud. Now i eat 1 time a day and i feel great. I feel alert, very focused, motivated, and physically fit. 146 Reply 2 replies Mieka Fasting Weight Loss Mieka Fasting Weight Loss 4 years ago So happy for a fasting video!! I have been doing fasting for weight loss for the last 125 days. Intermittent fasting, OMAD one meal a day, and water fasting. Lost 65 lbs. 35 more to go. 518 Reply 48 replies Diana Tutt Diana Tutt 4 years ago As a 66 yr old Catholic, fasting starting at about seven years old was common. Eat dinner Saturday night. We never had snacks or pop anytime. Sunday we went to Mass & if you ate the Eucharist, it was on a clean empty stomach. During Lent we also fasted for spiritual reasons. It is not uncommon for us to fast anytime of the year. The people of India, Native Americans also fast spiritually. 11 Reply Siva Srimakurthi Siva Srimakurthi 3 years ago I am vegetarian, and I have been practicing 16/8 fasting about 9 months now, it really improved my health. lost about 20LBs. My cholesterol numbers dropped into normal level now. At the beginning it was really hard but after 3 to 4 months it became super easy, and I don't feel hungry for about 16-18 hours. IF worked as a miracle for me. 5 Reply Chethak M.P. Chethak M.P. 3 years ago Intermittent fasting! I have been doing it for a little more than 3 weeks now. I fast from roughly 4pm to 8am the next morning. It's been amazing. I now feel like enjoying life more and concentrate or worry about eating food much later. 10 Reply Emmy Emmy 1 month ago I usually try to do a 5-day water fast once a year. For this year's fast, I noticed I had a very swollen tender lymph node in my armpit no other symptoms, just the lymph node so I started my fast and within 3 days it was completely shrunk down to where I could barely feel it. So it definitely helped my immune system. I will still be getting the lymph node checked out though just to make sure there's no other underlying issues. But I thought that was an interesting result. 2 Reply Kamilla Tóth Kamilla Tóth 3 years ago Good vid, I have 2 additions / corrections tho: 1: Juice breaks your fast, as it triggers a metabolic response (because it contains calories). You can, however, have a small amount of salt (preferably sea or Himalaya salt) during a water fast to replenish electrolytes (salt doesn't have calories) also, some people would say you can have anything that helps with being in a deeper fasting state (these are: black coffee without anything added, water with apple cider vinegar, green tea (use a blend without fruits or berries in it), cinnamon in your drinks and a small amount of lemon juice) 2: if you do alternate day fasting, you should only have the 500 calories if you won't eat for OVER 24 hours. Meaning you go for a full day of the week without food, as well as up to breakfast the next day (and from dinner the previous day), in which case you would be fasting for around 32 hours. You should have the small meal all at once tho if you can and not spread out, as to allow your body to reduce insulin levels to baseline for as long as possible. Also, the 500 calories is not leading. You can have 1/4 of what you consume on your non-fasting days. If that's only 1200 calories, you should not consume more than 300 on fasting days. But if you normally need more than 200, you can have more than 500. 15 Reply otokodate83 otokodate83 4 years ago Been intermittent fasting almost a year now on a 21/3. I've never felt better in my life. I enjoy foods I love in reasonable ways, maintain a healthy weight, train regularly, and look younger than I did 5 years ago. If anyone is considering an easy to adhere to lifestyle change to boost not just your fitness, but overall health...I couldn't recommend intermittent fasting more! Do research and learn more thru videos like this and give it a shot...its easy and effective I promise!!! 10 Reply Douglas Mouat Douglas Mouat 4 years ago I intermittent fasting or as they said in video, window fast every day. Started with 10 hour eating window and have condensed it to 4-6 most days. Once a month I throw in a 24+ hour fast and love it. I've lost 50+ lbs went from a tight 38" waist to loose 33" waist size, have more energy, better skin and mental focus. I also noticed I send less money on food which helps be buy better organic or grass feed choices which further the health benefits. Making this life style change has be one of my best decisions ever. 1 Reply Nadja Davidson Nadja Davidson 4 years ago This was a really good introduction to fasting and food restriction. My only criticism is that the video clips you chose shows people eating fruits and simple carbs like bread and pasta. I cannot stress enough how important it is what you eat when you actually come out of fasting. You need to load up on vegetables (squash, tomatoes and potatoes are NOT vegetables), especially green leafy ones in order to supply your body with the essential micronutrients, particularly minerals. 5 Reply Mel Will Mel Will 3 years ago I am currently doing the 16-8 intermittent fasting at age 61+ and I am doing great with the help of God. Planning to move to 20-4 very soon, like next week God willing. To God be the glory every time.🙏🥰 13 Reply santsuma santsuma 3 years ago (edited) Fantastic video! I have been doing OMAD for more than a year. It's the best diet ever! I focus on nutrient-dense foods, no industrialized "pseudo foods", no soft drinks. Result: health, energy, simple. 28 Reply tracie renshaw tracie renshaw 3 years ago Interesting video with very interesting comments I thought/felt to begin intermittent fasting couple years ago Works great for me I'm not a strict time person, I just enjoy NOT eating after 6/7pm but hey on times it can be earlier/later Same goes for breaking my fasting 11am/12 on times that can also change. What I enjoy more than anything is how brilliant and aware my body is to what I choose to take in. Oh my, an occasional late late meal, can change the feel of an entire day after...sluggish, foggy feeling not as bright as I believe myself to be...ha ha But it's a fab part to my personal research, what feels fab for me. I hope all others own and enjoy their journey with foods I'm a vegan gal...who loves mostly RAW fruits and veg, I do occasionally cook. Have a lovely journey with food. 4 Reply ChubbyNinja ChubbyNinja 4 years ago I typically fast for 5-7 consecutive days each month. I typically only feel hunger for the first couple of days. After that, it's just a waiting game. The reason I fast for so long is because long fasts like that stimulate the production of a massive dump of stem cells. So, not only do you have a full week of nonstop autophagy cleaning out your body of old and damaged cells, but the following week you get flooded with stem cells to rejuvenate your body. I feel like Captain America during the week after a fast. It's AMAZING. 677 Reply 83 replies Carolina Paez Carolina Paez 4 years ago (edited) So interesting! I have lost 8 pounds in 6 weeks just fasting 10/14. It was hard during the first days, but after that my hunger has totally disappeared after 4 pm. I feel 20 years younger. I don't have sugar cravings or desire for unhealthy food choices. 2 Reply RAMIL RAMIL 4 years ago I'm into 18 to 24 hours fasting everyday, with some breaks on special occasions where sumptous foods are served. I started with the 12-12 duration. I fast even on days when I hit the gym for at least 1 hour of intense workout (irregularly, BTW). It has been 4 years. I'm 52, but I feel and look younger, modesty aside. At 1.78 meters, my waistline is 30 inches, going 29. BP, blood sugar, etc. all normal. All I'm saying is: I.F. works. One important bonus: you learn self-discipline. Reply Everfitcoach Everfitcoach 3 years ago I've been doing a 22hr fast every week since Sep 2017 and a cold shower every morning since Nov 2015. Getting cold and going hungry are two of the best and cheapest ways to improve health and performance. 129 Reply 4 replies Polly Maria Williams Polly Maria Williams 3 years ago Since January 2019, I’ve been fasting by doing IF (20:4 or 24 hours) and once a month I do a 3 Day water fasting. I’ve lost 27 pounds. I am happy I found out about fasting it is the only thing that works for me. I don’t eat junk or carbs anymore. Reply theobsessor11294 theobsessor11294 3 years ago Lost ten pounds in two weeks, while eating one meal a day. It absolutely works, and I’m not even being paid to say so! 12 Reply 1 reply Supriya Priya Supriya Priya 4 years ago I'm undergoing intermittent fasting for the past one month. The results are amazing. I'm totally feeling energetic and my hunger is slowly vanishing. I've lost 4kgs till now. And, autophagy is a superb information. 57 Reply 8 replies fumblerooskie fumblerooskie 4 years ago I do the 8/16 fast, where I only eat between 10:00 a.m and 6 p.m. I find that it's a LOT easier than I thought it would be. I just need to make sure I consume enough calories during those eight hours, which is harder than you might think since I feel full after even small meals. So I have a snack every two hours, and as big a lunch as I can handle. I also drink a lot of water at night, which helps me feel full. Reply Half House Half House 4 years ago (edited) I agree. I've been skipping dinner most evenings (80% of the time) for the past few years. I feel better when I wake up in the morning and my blood sugar, cholesterol, and blood pressure levels are within normal parameters for my age. 2 Reply Ashique Desai Ashique Desai 3 years ago The title should be - ONE DAY FASTING - not ONE DAY STARVATION. 1.2K Reply 27 replies Tom Tom 1 year ago I do 16/8 almost every day, sometimes it's more like 15/9, due to getting home a bit later than I should from work or smth, but not a big deal, I also now do 24h fast every sunday noon to monday noon. Been doing this for a while now and feel great. Weight is under control, need less sleep etc. That's with other lifestyle changes included, making one change for the better usually motivates you to make more positive healthy changes, it's like a snowball effect. This, imo, is the easiest one to start with, doesn't really cost you anything etc. Reply Eliza Day Eliza Day 3 years ago This was well explained in a concise way. Intermittent fasting of 16/8 works well for consistency. 6 Reply Fabio Fabio 4 years ago Have been doing fasting over a year , 20h fasting and eating for 4h low carb and almost 0 sugar meal I never been so lean and by fasting you stimulate your growth hormone 20 Reply 1 reply JIMMY JAMES JIMMY JAMES 4 years ago Just a quick question? Been playing around with fasting for about a year (16/8) and a few months ago I decided to just push it and just eat once a day which is probably the best decision I ever made, I dropped about 30 lbs. and I never felt better, my question is can I do this long term? Any bad side affects to this? Reply Jade Moon Jade Moon 3 years ago I started restricting calories and fasting everyday - the equivalent of one meal or nothing - and doing yoga everyday after I put on like 50+ lbs in a bad relationship. The pants I used to wear aren't just loose, they fall right off. But because I work out, I'm not skinny. I'm quite muscular. And my skin is clearer. I rarely wear foundation now. I cut back a lot on sugar and try to avoid greasy food because my stomach can't handle it. My body protests if I eat junk. I just don't feel like my body needs the amount of food I used to eat. I'm not strict or anything. If I'm hungry, I eat. If I want ice cream, I eat it. I just don't eat a lot and I'm good for awhile. My people used to fast for long periods of time and didn't have dairy or fine sugar or refined carbs up until a couple centuries ago. I think genetics plays a huge role. I mean, that why I'm lactose intolerant and diabetes is ravaging my people. So if my body is set up like that, I think I'm meant to calorie restrict and fast. I don't move my entire community partway through the year, so I don't need to bulk up on food the way they did. I live everyday like their summers, easy, so I should eat like that. I think eating to suit our individual needs is important. One of the reasons Europeans called my people savage was that they didn't eat 3 square meals a day. When asked when they eat, they apparently said, "When I'm hungry". I totally agree with that mindset. 1 Reply Sean Awesome Sean Awesome 3 years ago Back in August I did my longest fast; 3 days! It was during a Festival of India, so the whole place smelled INCREDIBLE! After the first day, the small of the food sustained me! 4 Reply moonbuilder moonbuilder 3 years ago Well put together and clear, thank you. I particularly like the idea of having a good breakfast followed by the 24-hours after that. Obvious, really but it had just never occurred to me. I have tried it and discovered the whole 24-hours without food thing far less daunting, especially if you push breakfast up to 11am or even later. Just a small point. I thought that the 24-hour-fast WAS a water-only-fast. You can't seriously be recommending 24-hours without water? I would have thought this was dangerous? What does anyone else think? 6 Reply 1 reply Amaranto Galindo Amaranto Galindo 5 months ago Ive been dealing with surgeries in my brain due to shunt ( device that helps to drain csf liquid ) malfuctioning after I was diagnosed with hydrocephalus. I had already heard about autophagy but didnt know much about it, this video breaks down very well all the benefits of adapting to eating windows instead of eating and eating...I will go very serious with this and i am excited to see what benefits it will bring to my life Reply Blue Panther Blue Panther 4 years ago I fast 24 hours two times per week. On fast days my lunch is the last meal of the day and I break the fast around lunch time next day. It is surprisingly easy to do once you accept a few stomach grumbles. There is a lot of scientific (and religious) documentation of fasting. Unfortunately it is oftentimes put in a bad light by research sponsored by food companies. All I can say is follow the money and give it a try... 35 Reply 4 replies illysmanx illysmanx 4 years ago (edited) I regularly eat just raw vegetables, with a protein meal about once every three days. It works incredibly well for smoothing over blood sugar spikes and keeping insulin requirements down in diabetes. 1 Reply Debbie Bunny Debbie Bunny 4 years ago Glad I watched this video! Now I understand a bit better why staying on a whole plant foods diet while occasionally skipping meals makes me feel so much better, plus I lose weight quickly! Legumes, whole grains, vegetables and fruit, that's the key! 2 Reply Mindy Newman Mindy Newman 11 months ago I lost 65 lbs. intermittent fasting and once a month 24-hour fasting. I also did a 72-hour fast. It's been 4 years and my weight may fluctuate but fasting works so well, that I easily kept the weight off. Reply Julia Datt This Model Eats A Lot Julia Datt This Model Eats A Lot 4 years ago I'm of Indian origin and I do this as well as told by my parents, it's especially helpful as I have my food channel on here and am always eating haha so take weeks off where I eat only home food and within this do intermittent fasting. 1 Reply Darlene Battle Darlene Battle 1 year ago Planning to water fast for 7 days to really tap into autophagy. I'd like to do this at the end of every month until I see serious results. I believe I can do it. Reply Stella 1800 Stella 1800 2 years ago I just came off a 4 day fast and my stomache is now totally flat! So happy! I wish I could see the effects of autophagy as easily. 6 Reply Gertjan Koolen Gertjan Koolen 4 years ago Fasting is a very powerful tool to fight many diseases. I have a restricted window of eating: first (healthy) meal at 1pm and the main meal at 6pm. I feel great, lots of energy in the morning. No hunger whatsoever! My body has more time to repair. Also once a month I do a 2-day dry fast for more cleanup. Also here: no hunger or thirst, and I feel like Superman afterwards. Reply Rajesh Kumar Rajesh Kumar 2 years ago I am doing 20/4 intermediate fasting with low carb keto, feeling great and healthy also lost 10 kg in 3 months...still making research with my body...keep going Reply Elena P. Elena P. 3 years ago Well, last 5 months I’ve been eating ones in 24 hours,a few times did 38 hours I feel muuuuuch better, not so tired like before. After Christmas planning to do blood test to see how it’s works. I am 68! 🙋‍♀️ 4 Reply bradley amor bradley amor 1 year ago Fasting is now part of my routine of life. I just started fasting and lost 35 pounds already and I only just started. I found renewed desire to be healthy , get fit as in my youth but at 62 I need to take it slow but sure. I used to eat and lift weights and never miss a meal when young then not for years , now I feel better because I do not eat meat except some fish but am now considering and will become vegan because I care. 1 Reply ARLYN FINADO ARLYN FINADO 1 year ago I love this article. It's very informative and very inspiring. Have a lot of options on fasting for better health. Reply Atul Jain Atul Jain 4 years ago I have choose for water fasting. Once a week i only take water and nothing else. And that feels really nice, and i also understood the importance of food and started not to waste any. 69 Reply 13 replies Mafat Gideon Mafat Gideon 3 years ago (edited) Okay , so I've been fasting Monday to Friday and I plan to do it for a month. My plan so far is to only eat dinner around 6:00pm -6:30pm , drinking water regularly and eating a fruit or nuts by 4pm. I eat normally on Saturdays and Sundays . How effective is this ? Reply Gregory Leon Watson Gregory Leon Watson 3 years ago (edited) I do all of these fasting techniques. The easiest fast is while you sleep and then skip breakfast. I can do a 16 to 20 hour fast simply by having my last snack at 10 pm , sleep as normal , then skip breakfast. At this point I have options. I can stop the fast at 12 hrs - 10am - or continue out to 2 pm - 16 hrs. At 2pm I may feel inspired and go for 20 hrs - 6pm. I found once I get to 20 hrs of fasting , sometimes I'm not hungry ; infact I get giddy. At this point going beyond 24 is easy - 10pm. I find I do a 12 hour fast everyday. By the way - I used to weigh 300 pounds. Now I weigh a very comfortable 219 and ware skinny jeans. I became vegan for 18 months ; this is when I gained control of my eating. But it's understanding glutin-free that makes all the difference. NO BREAD is the easiest diet. I eat meat when I crave it - but I'm super strict about wheat. Reply Vivek Sir Vivek Sir 3 years ago I am following his diet since last 14 months and it really helps i have lost 28 kgs process is slow but surely it helps. 3 Reply Justin Virly Justin Virly 4 years ago I've been practice fasting every now and then for about 10 years. Sometimes I'd select a day to fast, or go dinner to dinner. These days I follow 16/8 every day, not having breakfast but once every month or so I skip lunch as well. I love it. It really resets everyone. Reply 1 reply Don Berry Don Berry 6 months ago I am 75 and have done some fasting for Autophagy. 1,2,3 or 4days. My energy level actually gets attention from my peers. I feel great 👍 but my Dr. is mad at me because I don’t use or need any medication 💊 anymore. 😇 Reply Allan Ø.N. Allan Ø.N. 4 years ago I just about to end a 28 day fast. (I am at day 28). Result loss of 15,69 kilos or a BMI from approx 29 to just below 24. Right now I’m tired and exhausted and lot of things have happened in my body during the fast. Excited how the coming weeks and months will work out ... 10 Reply 4 replies bjulia33 bjulia33 4 years ago I learned of IF and dived in with an extended water fast. Aiming for a week, made it 3 days. Wish video covered this. One thing I DO know: that 2,000 calorie one day and 500 the next is a recipe for failure for most .... or maybe just me. I work better in unbroken streaks. One slip usually leads to a long disappointing slide, although mastering self-criticism helps turn the tide. And of course food is not a zero-tolerance addiction, only harm reduction is possible. Reply henrickno henrickno 3 years ago Just finished 14 days of water fasting. Feeling great!!! 4 Reply 1 reply befunkrn befunkrn 1 year ago I sure wish I'd started earlier, but at least I started daily Intermittent Fasting the last 2 years with 1-1.5 very healthy nutrient dense meals/day. With daily IF I've continued to lose another 25-30 lbs that I couldn't lose before. I had dropped from 230 to 200 but couldn't lose any more til daily IF, now I'm finally down to 170+ with only another 15 or so to go! I waited too long to start & became Diabetic (type 2) but with daily IF my Hgb A1c is all the way down to 5.3 (normal!). I believe in IF! Reply Ahingge Ahingge 2 years ago recently i try water fasting for 84 hours, my body feel great after fasting, like I am turn into another person, more energy, more motivation in life. So I will keep this fasting as my life routing from now on. 3 Reply Untwisting The T Untwisting The T 3 years ago I've started doing the 16:8 fast once I had an appt for high liver enzymes with my hematologist . He told me the basics and that I could live longer and feel better if I reduced my sugars and gave intermittent fasting a shot. I tend to give doctors that treat cancers and blood disorders more credit with information that is cutting edge. I feel less depressed now after 3 months of doing this. I'm losing wait. I don't starve myself. I just cut breakfast into brunch. And I'm even finding that I graze less by eating a big lunch, tiny snacks and a small dinner. Just be careful when you have blood sugar issues. The first week I got moody and woozy before my first meal of the day. The good thing is you can find apps and websites to help you with any kind of fasting. You can find many apps that have timers and calendars to help you make it a habit. I feel so much better. I also have a cousin in the army who does it and he looks amazing. He says he feels less achy to. That being said my father has eaten 3 square very healthy meals a day for decades and he's the healthiest person I know. And not just for 67. The man still runs a few times a week and he's fast. I'll make a channel soon about the health habits of my family. We are very invested in prevention in my family. Reply Larry Hutcherson Sr Larry Hutcherson Sr 4 years ago This video was very informative. Thanks for the deep dive into autophagy. I have been needed some encouragement about this for a while. 3 Reply Mel Will Mel Will 3 years ago Ok Brethrens, I started my OMAD diet 22-2 doing good so far. Hope to continue for the rest of my life, Gods willing. Blessed love to you all.🙏🥰 7 Reply 1 reply Bhoopal Roheria Bhoopal Roheria 3 years ago My detoxification is, one meal at 10-10:30 am in the morning or other is 7-7:30pm in the evening. That means 9 hours of gap between the meals. I am very much on the track but needs to be consistent everyday. 🙏 Reply n d n d 3 years ago I never understood why I felt physically clean after fasting in Ramadhan until this video! 398 Reply 45 replies THE AMAZING INFO THE AMAZING INFO 3 years ago Amazing video of my life.. transformation..prior to this i was not aware that eating too much protein can actually damage u..fasting is a culture in india from so many centuries..!! Ancient people theroies now going into work..have a happy and healthy life mates.!! 6 Reply 1 reply Poco Loco Poco Loco 3 years ago I already have done waterfasting for FIVE days. From 2/06/019 to 06/06/19.. Feeling better then everbefore... I recommend it to all..but be aware of your health condition before starting any long water fast... Have a nice day 3 Reply Erzebeth Cavanaugh Erzebeth Cavanaugh 4 years ago When i was in college and i literally dont have money to buy food so i had to only eat once a day to save. I felt so much better back then cause i felt energetc all the time and get high grades. Now that i have money and work i eat 3 times a day no exercse, and most of the time im sleepy and sloppy. 526 Reply 34 replies Angel's Diary Angel's Diary 1 year ago (edited) Hello everyone, is it normal to lose so much hair while on IF? I started doing it last year, April to be exact. And from then on, I noticed I've been losing so much hair. I still do IF to this day, but I am worried because I noticed that my hair is thinning. Reply Vimal Singh Vimal Singh 4 months ago Well it's great really. An ancient practice introduced by great Indian sages thousands of years ago is finally reaching the world. How great were these sages and great work for bringing to the world's attention Dr. Everyone will benefit. Reply 0ഠÅrJuÑഠ0 0ഠÅrJuÑഠ0 1 year ago In Ayurveda one should only consume food in Sun Cycle, it is said our digestive fire starts with sun rise, it peaks at noon and end with sunset. So it is preferred to eat medium portion at morning, big one at noon and low before sunset. 10 Reply 2 replies epSos.de epSos.de 4 years ago Helpful video. It explains why fasting cleans up the body well. Like bringing out the trash and clean the house. 18 hour fast is very easy. Eat at 12:00, then eat at 18:00, which gives us 18 hours of fasting till the next day ;-) 17 Reply 2 replies Parveen Chander Khulbe Parveen Chander Khulbe 4 months ago I reduced my 18kg weight after adopting a regime of one meal a day and walk 10 km in seven days a week .. now i feel weight less and more energetic..IN INDIA OUR ELDERS ARE DOING THIS WAY OF LIFE SINCE CENTURIES ... Reply CJ CJ 4 years ago Autophagy is very interesting process that we have in our body . All must go for fasting ,so we can reduce cancer and diabetes .. thanks for your information 19 Reply Rockhead Gary Rockhead Gary 3 years ago Autophagy onset speeds up with fasted exercise. It’s easy to fast after a week or 2 after giving up breads and sugar. I do intermittent/time restricted eating most days. I do 1 24 hr fast a week and a 48 hour fast about every 6 weeks. I can honestly say that I am in the health I have ever had. Moles and loose skin disappears quickly. I lost 25% of my body weight and have never been stronger or fitter. It takes about 18 hrs of fasting to get to the start of autophagy, sooner if you work out fasted. At 3 days fasting, autophagy drops off sharply, mouth weight loss speeds up. Intermittent fast for awhile before doing a longer fast. Reply YugoRr YugoRr 4 years ago I’ve had unplanned fasting after forgetting to eat. With only a breakfast meal I would build up stomach ache in the evening. Only after eating something the pain would go away over a course of ~1,5 hours. Reply Itsu Blayt Itsu Blayt 3 years ago I do fasting since childhood, especially when there is nothing to eat. 😂😅😂 254 Reply 9 replies Pooja Joshi Pooja Joshi 2 years ago Fasting is a very natural lifestyle method in Hinduism. This video made me realize its scientific value . Thanks 10 Reply 1 reply Beth Diaz Beth Diaz 2 years ago I started OMAD weeks ago. My diet is plant-based. I realized my body really doesn't need animal protein. I have never felt better and more energetic. And thanks for this video. 14 Reply Pinki Kaushik Pinki Kaushik 4 years ago In Ancient India, fasting for a whole day was necessary in a week. Even now I see my parents doing fast for Monday every week. They tell me it's necessary for body and it boosts metabolism. They do only drink water and milk that fast day. I was glad to know the real reasons behinds that fast which my parents are doing without knowing proper reason, as they were told to do by there parents. But I can't resist even a single time meal. I tried many times but can't resist. 161 Reply 30 replies K Kenason K Kenason 4 years ago Intermittent fasting has changed my life. I've lost significant weight in the midsection and feel great with amazing energy and mental focus. I only eat between 12 and 6. I eat lunch, dinner no snacks and water only. I cheat only one day a week usually Friday. Diets are a pain and can be expensive. I should have tried intermittent fasting years ago. 6 Reply Pete T. Szmurlo Pete T. Szmurlo 3 years ago I fasted for 21 days starting 01/01/2019 and dropped 38 lbs! I also eliminated high blood pressure and pain associated with My ankylosis spondylitis. My clothes fit, the fog has been lifted from my brain and I jump out of bed eager to meet daily challenges without any procrastination! Give it a whirl...you just might find a better YOU! 3 Reply 4 replies Colonel Sanders Colonel Sanders 9 months ago Whenever I am on a fast or doing a calorie restriction I always notice my skin is clearer and finer + I can focus so much better :) Reply CKCLUTCH CKCLUTCH 4 years ago Thank you for your work, Doc. 🖒 Reply Maxx Power Maxx Power 1 year ago Yepp, all true. I eat between 5pm-7pm only (22&2 hour cycle). My BP, lipids, cardiac calcium scores/levels are perfect. I could never go back to eating multiple meals a day full time. Give it a try…. Reply Leif Mealone Leif Mealone 4 years ago I generally do OMAD (one meal a day). No Carbs. Lost weight and feel great. I highly recommend getting onto Ketosis. Once you are in ketosis it's easy to fast. I did a 72 hour water fast and it was easy because my body was already living off ketones. 5 Reply J. Liberty J. Liberty 2 years ago I fast 21 hours every day. I eat between 4:00 and 7:00 p.m. I always have lots of energy in the afternoons for exercise. I love it. Reply Taichiro Ward Taichiro Ward 5 months ago I don’t eat every MW&F after I learned about the bodies fasting mechanism in med school. Fasted for 30 days once just consuming water. It was intense. Reply Liz Masi Liz Masi 3 years ago Ketogenic diet and intermittent fasting! Have done 16/8, 24 and one time I did an 84 hour fast. 49 Reply 3 replies zinazu zinazu 3 years ago I have a question, how about if I’m skinny and don’t want to loose any weight (want to gain what have been always a difficult task) and also my metabolism is pretty fast, hungry almost every two hours.... I see all the positive impacts and would love to do but still have this question on my mind if it’s suitable for everyone or how does it work :) Reply John per ardua John per ardua 5 months ago I started with a 20/4 fast and used the time I was sleeping that obviously counted towards it. Eat between 5 and 9 pm and fast the rest, made it easy. Reply Blank Slate Works Blank Slate Works 4 years ago I’ve worked to adapt to a 16/8 system but recently also switched a couple days of the week to vegetarian/vegan inspired meals and reduced my meat portions to 3-4oz. As much as I love a big juicy steak I was eating way too much protein. 26 Reply 2 replies k dark k dark 4 years ago THANKYOU for this UNIBIASED video.❤🙇‍♂️🍀 Back in the day when i used to do IM on boiled Meat and chicken with brocolli ,i was Feeling WORSE,lethargic and did that for about 1 year,developed GERD,my IBD worsened so did my Pstd and depression and anxiety and had so Much lethargy and got severe acne and got Kidney problems with Low GFR and high Creatinine. BUT When i switched to Whole Plant based Foods direcrly grown from.earth(a Vegan diet) with a lil bit of intermittent fasting,within Only 5 months all i mean ALL my symptoms of various comditions got cured and i Lost tonns of weight and Felt tonns of energy ans have Never felt So Alive ,athletic,muscular and healthy🙇‍♂️ Reply Actaeon Actaeon 3 years ago Just finished an 11 day water fast. Day 12 was juice. Days 13-17 were reintroduction on fruits, vegees, then grains. Lost 27 pounds during that period. Ate plant-based no salt, no sugar, no oil diet for two weeks. And now am doing intermittent fasting 16 hours fast/8 hour feeding and remain on non-SOS (salt, sugar, oil) regime. Have lost total of thirty pounds in 29 days. So much energy on intermittent fasting schedule and losing from 1/2 to 1 lb a day. 100 pounds to go. Feels great. Prolonged water fasting is a life saver🙂 8 Reply Ash Ash 3 years ago Indians figured it out thousands of years ago, it is mentioned in the Ayurveda. Hence fasting is an important practice in Indian tradition. 358 Reply 38 replies NavShay NavShay 4 years ago It's important to note that while body needs food to survive, digestion of food is a stressful process for the body and fasting helps in restoring digestive organs while allowing the immune system to work on other needed areas Reply arpxdagoodone arpxdagoodone 3 years ago I've started 16-8 about 2 months ago. Actually I didn't change anything in my diet (maybe I eat less) except I have this 8 hour time window, but what I've noticed that nothing has changed. Maybe I've lost a couple of kilograms, but that's it. Probably my blood sugar is still high, because after I eat I have a little headache and dizziness. Maybe 1 and a half months is not too much, but if this will be the case after 1 and a half months more I will assume that IF is only effective if you reduce carbs, sugar and calorie intake...which is of course understandable...but if you reduce these thing then it doesn't matter when you eat throughout the day. But in this case I have a question: What is the point of doing IF? Reply Millionaire Mindset Millionaire Mindset 4 years ago 👍 He who can take advice is sometimes superior to him who can give it. 221 Reply 9 replies Anjali Rajan Anjali Rajan 1 year ago Indians always do fasting on a holy day of their culture , it promote different types of fasting, like on ekadashi, navratri, chatt puja and other puja also... Sanatan dharma known to all these things very earlier. 🙏🙏🙏 4 Reply Ripunjoy Borgohain Ripunjoy Borgohain 4 years ago I'm a vegan and I follow intermittent fasting...16/8, 4 days a week and 20/4 the rest of the days...when I began doing this I completely transformed my body from a moderately chubby (64 kgs with 5"4) height to 58kgs with all lean muscles within 2 and a half month...I did take vegan protein powders though but nothing more Reply OMAR 99 OMAR 99 1 year ago That's why in Ramadan i always feel healthier mentally and physically :) 13 Reply Georgios Efstratiadis Georgios Efstratiadis 4 years ago Great video...I would like to give you guys my way..1 day salad(500g) at noon and 1 fruit at evening..next day only water next day the same as the first day. P.s for salad I prefer lettuce olive oil and red vinegar. For olive oil I prefer Mesinias (Kalamatas) First 2 weeks I did have energy problem but 3 one I was perfectly fine, I start January 2018. Good luck and stay fit and healthy in mind and body. 4 Reply Erik Danskine Erik Danskine 3 years ago What if you're trying to increase your weight but you also want to do it in a healthy manner? Reply Ankesh Kapil Ankesh Kapil 3 years ago While i am watching this video, people of my country(India) are celebrating Navaratri Festival where one needs to do intermittent fast for 9 days. 270 Reply 14 replies James Sizemore James Sizemore 4 years ago I started a 16/8 fasting schedule about two months ago. It's going well. Reply 1 reply Jamedra A Jamedra A 3 years ago My IF schedule is 20:4 and I do a (soft) dry fast the first day of the month. Reply kittendivine1 kittendivine1 2 years ago If you eat too little protein, wouldn't that cause muscle loss? Do you have to eat extra protein on the days you don't restrict protein? Can you reduce protein intake everyday? 1 Reply Tom Chupick Tom Chupick 3 years ago When I lived in India I fasted 1 day per week and had a noticeable boost in cardio performance the next day. This led to fasting Fridays, and no meat Saturday’s before Sunday’s with 10 km races. You may improved your 10km time by up to a minute. 4 Reply 1 reply a church a church 3 years ago I like the once a day eating diet. A window between 6 and 8 pm. Huge boost in energy, Dinner with the family every day. Money I spent on convenience food is buying my new car. AWESOME!!! Reply lovessox lovessox 4 years ago Does this also explain why when you are sick you don't feel like eating? 161 Reply 13 replies Ethan Hurt Ethan Hurt 4 years ago I eat one meal a day. I do 23/1...And I lift weights and do light cardio fasted. My weight is higher now than a month ago but my waist has lost 4”. 1 Reply vinay k vinay k 3 years ago Absolute truth told ....and proved scientifically 8 Reply J is a FAAACCCT J is a FAAACCCT 3 years ago meanwhile here in the Philippines if not all most parents and elders will get mad at you if you don't eat or if you skip meal because according to them the air in your stomach will get into your head and you will become "taong grasa" 😂😂 and everytime i feel ill their first question would always be about food maybe you skip meal? maybe you didn't eat enough etc. that's why i just believe them for world peace! 😭 3 Reply Vadrevu Charitha Sreya Vadrevu Charitha Sreya 3 years ago Intermittent Fasting (IF) suits us quite a bit. It keeps the body fit and slowly reduce weight too. Reply A. Alberts A. Alberts 1 year ago This video says vegetarians are fine with intermittent fasting. My problem with veg is it leaves me HUNGRY. I'm doing keto now, and get full on Half what I normally served myself, and having two instead of three meals a day (and that's not counting all the snacks I used to eat). It's amazing I wasn't obese. Reply Markonjero Markonjero 4 years ago (edited) Orthodox christians have more than 100 days of fasting during entire year (Great Easter fasting 40 days, Christmas fasting 40 days, and two small fastings around 15 days). This means eating only plant origin food, and sometimes fish. Also many days of fasting is on water (not using anything with oil). Also, besides this days every wednesday and friday is fasting day. And we do it for 2000 years... 48 Reply 2 replies hari sneha hari sneha 3 years ago In India we have the practice of fasting every fortnight on the 11th day of full moon or new moon. Such practices have come only in the name of tradition. But there was some reason which is lost new. This video shows the reasoning. Thanks for the same. 1 Reply 1 reply Golden Leaf Golden Leaf 4 years ago thanks for all the encouraging comments about fasting...it will help me ...so it benefits you both physically and spritually... 1 Reply Gloria Chan Gloria Chan 3 years ago I have been doing fasting regularly, but now only understand how fasting benefits our body system. 1 Reply Hamsters-N-Harmony Hamsters-N-Harmony 3 years ago it sounds like a whole lot of work to do a diet when fasting you don't eat and don't have to worry about it, and it's faster too Reply My eXtreme PC My eXtreme PC 3 years ago (edited) Today is my seventh day of water fasting and I've lost 18lbs. 14 days to go 2 Reply 1 reply sara Solomon sara Solomon 3 years ago I don't eat breakfast every day. My first meal at 2PM then at 5pm. Then I don't eat until next day 2pm I have been doing this for 6 month. I feel good❤ 3 Reply 1 reply Neemo Lovely Neemo Lovely 4 years ago I've tried the OMAD one meal a day for 5 months and still on it .. I loved and it works for cause I practice yoga daily 1 Reply Quantum Enigma Quantum Enigma 3 years ago Fasting has tremendous benefits, widely followed across different cultures. Modern science now able to recognize these benefits🤗👏👏 4 Reply Dinesh Kumar Dinesh Kumar 1 year ago In Hindu culture we are practicing fasting once in 14 days from thousands of years, however in modern generation very few are practicing 4 Reply Jeaux Schmeaux Jeaux Schmeaux 4 years ago “...juices without sugar...”. That’s a good one. 438 Reply 20 replies Paul Higgins Paul Higgins 2 years ago I tried macrobiotic diet in my 20's, brown rice&veggies mostly,then a10 day waterfast. Working as a chef at the time,I kept my regime to myself. 1 Reply 1 reply Pattiesd Pattiesd 3 years ago Great video!! Can you please do a video on the sauna b12 detox method and the science behind why it's a good detoxing method? 3 Reply The SamsungExperiance The SamsungExperiance 3 years ago I do 24/H fasting every day and drink nothing but water and black coffee and I lost 1 stone in 2 weeks which is my water weight and now I lose around 3 pounds a week. Reply daoudech freiha daoudech freiha 3 years ago That's why i feel clean and healthy after the month of Ramadan ❤️ 3 Reply AirgunTuning Pro DragonArms Genesis AirgunTuning Pro DragonArms Genesis 3 years ago when i was young i watched a doctor on tv say that the best would be to eat every two days,he was way ahead 25 years ago 45 Reply Chuck LeeClerk Chuck LeeClerk 4 years ago (edited) I eat in a 2 hr window and I need protein everyday ( mostly HIIT training), I managed 3 day fast but that's quite a torture esp while being still active - training as usual. Reply 1 reply Radek Látal Radek Látal 3 years ago Longer I watch this video, the more it becomes the game of "spot the error", so many errors... e.g., the increase of the nitric oxide production in the arteries has more to do with the food you ate before you started fasting, than the fasting itself. Most of the people's diets contain a lot of compounds, which cause inflamation in the arterie lining, such as saturated fats, trans fats or free radicals such as oxidated cholesterol, which reduces NO production. Once you stop insulting your arterial tissue with these harmful compounds, it recovers and resumes the NO production. So many errors... you can do better guys. 4 Reply Sun Li Sun Li 3 years ago (edited) You can't call a one-day fasting "starvation" 29 Reply achillesfury achillesfury 4 years ago Warrior’s diet I eat 1 meal everyday, for 2 years now Gives me optimal health and the flexibility to adjust or not follow in social events. 2 Reply 1 reply TheMkhair TheMkhair 4 years ago Hello! I have been fasting intermittently for about 8 weeks now. I do the 20/4 method. I have lost 7 kgs but hit a plataeu. How can i kick start the weightloss again? Reply frances frances 1 year ago autophagy and info on different ways of fasting was really interesting 👍👍👍 Reply Jaspreet Singh Jaspreet Singh 3 years ago We went through millions of years of evolution for this. Human body anatomy is fascinating. 2 Reply Keith Pillay Keith Pillay 9 months ago 100% agreed,,, for some people it's starvation 🙄 Reply North Star North Star 3 years ago All religions have fasting days or weeks. It Just has different names. This man explained scientifically the result of it 161 Reply 11 replies David Skaggs David Skaggs 4 years ago The Greeks and Romans knew the benefits of fasting so did many other cultures thousands of years ago it just seems more difficult due to new marketing strategies. I lost 70 lbs last year with various fasting methods😁 Reply Nitin Nitin 4 years ago (edited) Indian moms are doing this for ages. And they are so humble that didnt ever want a Nobel Prize for sharing the secret. 😊👍 1 Reply Murali Venkatakrishnan Murali Venkatakrishnan 1 year ago Hinduism talks about "Ekadashi nirjala upavaasam " - Full day starvation (not even water) every fortnight. Exactly coincides with this research 10 Reply 1 reply Clifford Harrison Clifford Harrison 4 years ago Fasting works because it keeps you from eating the toxins in almost all foods. There is a huge list of problems with most commonly eaten items. A 4-day rotation diet can help if you totally avoid the worst foods: wheat and dairy. Reply Lilly Walsh Lilly Walsh 2 years ago It has an amazing health benefits! 2 Reply Aquib Mohd Aquib Mohd 3 years ago Watching this while fasting. It's been 12 days of fasting 70 Reply 6 replies sk8queen sk8queen 4 years ago When I was a teenager 35 years ago, I ate lunch and dinner and didnt eat after 7 PM. I lost 85lbs in one year. 35 years later, I will wear my Sr. class tshirt to my class reunion.... I didn't know I was intermittent fasting at the time. My mom just suggested I not eat after 7PM. Inflammation definitely went away as well as lowered blood pressure was a result in addition to the weight loss. At 53, I think I will start alternate day fasts.. 1 Reply Hridai Herbal Essentials Hridai Herbal Essentials 4 years ago I am following 18/6 diet for the past 45 days, It is not difficult. My first meal at 9am and last meal at 3pm. After & before this solid meal I take Herbal teas like Green Chiretta, Bilvam, Gymnema or even Senna. These Herbal teas help detoxify body. Reply Yasmine Boussaid Yasmine Boussaid 3 years ago Great video it shows that fasting is not only a religious ritual but a body healing process Reply 1 reply myartinjon myartinjon 4 years ago I'm surprised why they didn't mention rigorous exercises which in fact stimulate the whole body functions that are requiring more proteins to augment the muscle tissues and repair damages as a result of exercises. 2 Reply Total Constructions Total Constructions 1 year ago In India we Sanatan Dharmi regularly practice this in real time. Normally twice in month, during day time we take little fruits, and for dinner light food grain. During monsoon season, this fasting is more and is correlated with some auspicious days like Krushna Janmashtmi. Thnx for sharing the logic behind our ancient culture. 4 Reply Restored Beauty Restored Beauty 3 years ago Dr Berg should be getting a nobel price. By the way fasting dates all the way back to the Bible but now people are just discovering it 🤷‍♀️🌻 63 Reply 12 replies John Morrison John Morrison 8 months ago One thing I love about a fast is saving money and time. It is cheaper than pills, and won't spoil with time. Reply anisha joshi anisha joshi 3 years ago Wow...this is ever known in our Hindu culture....where we fast on some particular days of every week or every month,which is believed to detoxify the body and make us more spiritual.... so much to learn from our culture 🙏🙏...namaste 1 Reply Meidy Yanuar Meidy Yanuar 3 years ago Muslims fast during Ramadhan (for 30 days) and intermittent on Mondays and Thursdays. We eat twice, one before dawn (5am) and another 6pm. What do you think about this fasting? is it beneficial? Reply debbie burns debbie burns 4 years ago Wish there was more info regarding fasting and seizure control. Reply Paulie Walnuts Paulie Walnuts 3 years ago Had been doing 16:8 for the past few months. Now doing my first day of plant only. Watch the Netflix documentary called The Game Changers which is all about MMA fighters and NFL stars only eating plant based and performing better than their peers that are meat eating, great show Reply Skyfall Deadpool Skyfall Deadpool 3 years ago The begging of year when I watched this . Me :" I will never miss a meal" Me today 50lbs later for doing One meal a day. Me" Ho ma Gaaad!! I take it back , this is amazing" 8 Reply srinivasan R srinivasan R 4 years ago Hi this is good informative video, actually in Hindu mythology or group of persons fast ( water fasting) once in 15 days..... This system is adapted centuries ago and dedicated to God..... Anyway good information sharing is always good..... 1 Reply Sai Prakash Belkeri Sai Prakash Belkeri 3 years ago All these strategies that you are sharing are being followed in India from since few hundreds of years.. We have particular days for Fasting called as Ekadashi - falls once in 15 days Depending on the moon's waxing and waning cycles. People also choose to have a particular day of a week to fast. Do explore on this.. There's much more deeper dimension to this than just autophagy. Unfortunately, trying to adapt the western culture, everyone here are forgetting such many other practices that were a part of our daily lives and had a direct impact on our well-being are being forgotten. Next time if you come across any Indian ask him if his parents or grandparents did anything such as this.. The answer will be yes 99.999% times. Reply Anindito Bose Anindito Bose 1 year ago Since ancient times fasting was a kind of routine in Indian system. Now after the Autophagy Nobel Prize this is being rediscovered it seems 1 Reply Srinivasa Chamanahally Srinivasa Chamanahally 6 months ago In Indian panchanga(calender) we have a day called ekadashi, and that day is ideal to fast, from more than 5000 years there is evidence that people do fasting on that day for 24 hours to keep ourself healthy, i am fasting today as today is the day called EKADASHI. Reply Moirangthem Vikas Singh Moirangthem Vikas Singh 3 years ago In simple terms have 2 meals a day . One at 9 am and the next at 7 pm in the evening. Its the best way to eat . It takes no effort . Have proper meals . Dont try to increase or reduce the quantity. You will lose weight feel better and be more energetic. I was able to lose 30 kg in 6 months . Just by following this . No food restrictions whatso ever . Just timing Reply Rosh Lepz Rosh Lepz 4 years ago FASTING IS NOT STARVATION!!! AUTOPHAGY IS HEALING. 312 Reply 6 replies Dave Jarvis Dave Jarvis 3 years ago I have one meal at 10pm everyday,I drink water and coffee at regular intervals and it seems to be working Reply Stylianos Kaitanidis Stylianos Kaitanidis 3 years ago I have tryed intermitent fasting choosing the 16/8 patern.After one month all me lab tests came down to normal and I discontinued also my antihypertensive therapy as the blood pressure fall below normal limits. 2 Reply kumar satpriya kumar satpriya 3 years ago (edited) In India we have been following this for centuries ... One days a week water fasting... No meals once the sun is down....only after doctors started suggesting to eat at regular intervals and ppl started following thinking the old ways we're not scientific , a lot us started getting this diabetics and cholesterol issue. Reply Herb Spencer Herb Spencer 3 years ago I believe autophagy increases while we sleep, especially in brain cells. Reply Dorian Philotheates Dorian Philotheates 3 years ago My great-uncle starved for years during the Great Depression and WWII. For more than two full decades his most ardent desire was to fill his belly just once, and then die a happy man. He remained hungry for about ten years after the War. Then, in 1955, he vowed never to have an empty stomach again — not even for a moment. Since then he has been eating about a dozen square meals a day with regular snacking in between. When he isn’t eating, he’s smoking, drinking, or sleeping. He is also quite physically active, still slim, and generally in a foul mood — especially when hungry, which is practically always. He’s not choosy either; he’s got his favourites but he’ll eat pretty much anything. He is currently 102 and still very hungry...I guess he experienced enough autophagy during the lean years of his youth to last him a couple of lifetimes. Reply Sain TV Sain TV 4 years ago I used to stay fasting for 30 days of daily 15 hours during Ramadan every year 3 Reply Byrd IsDaWord Byrd IsDaWord 3 years ago I rotate my fasting days.. I may eat two meals today.. Nothing but water tomorrow... 3 small meals the next and then one meal the day after that and so forth. The days I eat the least or not at all i workout. I've lost 50 lbs so far 🤸🏾‍♂️🤸🏾‍♂️🤸🏾‍♂️🕺🏾🕺🏾🕺🏾 3 Reply Mythily Ramesh Mythily Ramesh 1 year ago The 24 or 26 hour fast once a fortbight during Ekadashi has been followed by indians for 100s of years. And we also do the twice a year 9 day Navratre fast which is one meal a day for 9 days 1 Reply HAVE LIFE HAVE LIFE 1 year ago It is fantastic to keep me in shape. After many years, it still did not rejuvenate my skin. Reply Surya Kumar Surya Kumar 4 years ago This video clearly explains autophagy than oshumi. I saw oshumi video fully but i can't understand it but this video explains in a easy way. I think NOBLE PRIZE should be given to this guy Reply Renalyn Luna Renalyn Luna 3 years ago I'm doing OMAD and IF for almost 5 months now and it changed my whole life 1 Reply 1 reply Blue Butterfly Wellness Blue Butterfly Wellness 4 years ago Vegan Keto 16:8 44lbs down and feel GREAT!!😊 8 Reply Netz Astigrockon Netz Astigrockon 3 years ago How about hyper acidity and gerd? How do you combat that while pasting? Reply Roger Sanidad Roger Sanidad 1 year ago I am on 1 meal a day diet for about 1 year now, I eat only at lunchtime and fasting on Sundays. Reply nataly fosberry nataly fosberry 2 years ago i do 16/8 4 days a week and i do water only fast 3 days a week every week .. and i am reversing auto ammune disease!! Reply MissInkling MissInkling 4 years ago Congratulations Dr. Yoshinori! Thanks for the info. Reply Pavaday Thondrayen Pavaday Thondrayen 2 years ago I do intermittent fasting 16/8. Sometimes my fasting period goes up tp 17 or 18 hours. But I haveThree cups of red wine every night from 5.30 pm to 7.30 pm and I have dinner at 7.30 pm. I have not lost weight at all last year and I have not gained weight also. Iam overweight at 75 kgs. After how many hours of fasting do autophagy starts.? I do not eat carbohydrate like rice, bread. I eat carbohydrate like 75 grams of bread or rice. Once a week quite rarely once or twice a month. I am a type 2 diabetes. What should I do to lose about 10 kgs? Reply Taoufik Chagdali Taoufik Chagdali 3 years ago I have a torn ligament in my knee and I tried water fasting for a week and my body just built a new tissue and ligament and I am free pain now Thank God who encourage us to fast to heal our bodies 8 Reply 2 replies Dexter Wegh Dexter Wegh 4 years ago Im on my 19th hour of dry fasting. Besides feeling a bit tired and having one hangry bitchfit in a useless discussion with my wife I feel quite good 🔥 Reply Koss Da Koss Da 4 years ago I eat within a 4-5 hour window 6 days a week a on 1 day I fast all day (usually 43 hours). Just started, am a 21 year old male 5’9” 165 lbs trying to get down to 145lbs. Reply IW Nunn IW Nunn 3 years ago Like the idea but I'd be afraid of not taking in enough calories when I do eat and losing too much weight Reply B1 Blac Butterfly B1 Blac Butterfly 4 years ago (edited) I did 21 days water fast. It was hard and easy on different days but loved the results with my body but hated what it did to my taste buds. And for that reason... I'll never do it again. Now I'm doing 16-8 intermittent fasting only it's better for me. Reply 1 reply Jorge carrejo Jorge carrejo 3 years ago I did a 16 day water and salt water with baking soda fast... As a type 1 diabetic.. People thought I was going to die... Reply Itsjustmethere Itsjustmethere 4 years ago a water fast should not include Juice at all 1.2K Reply 52 replies Jame Pinotes Jame Pinotes 4 years ago (edited) Well, I see that this topic is very interesting. I hope I can work on this too! Thank you! Reply Hamsters-N-Harmony Hamsters-N-Harmony 3 years ago i'm on day 5 of fasting. the first day is the hardest to get in my opinion and then it's still tough to keep up until day 3. ive done fasting before and i've survived a 14 day water fast. it's probably easier if you live alone, because you don't have to see others eat or smell the food. for me i have a big family in a small house, but i still do it by staying out of the kitchen and not looking at the food. i hope everyone trying to do a fast can get some motivation from this. 3 Reply Alchemist-A Alchemist-A 4 years ago Water-only 24 hr fast 3 days a week (in a raw). The other 4 days I skip breakfast and start eating lunch at 12:30 pm, and that is when I get my coffee. Dinner is at 6 pm followed by coffee and a snack of nuts and seeds. Reply Saiyedul Mursalin Saiyedul Mursalin 3 years ago Watching this as a Muslim I am very proud that how scientific and healthy fasting is for our body and it is compulsory for us (Muslims) to fast in the month of Ramadan for 1 whole month 16 Reply 3 replies zibtihaj zibtihaj 1 year ago How long does it take for the Autophagy process to start on a diet ? I thought science has not yet figured that part out yet ? Reply Shevin Vouce Shevin Vouce 3 years ago Thank you for this. Great information 1 Reply Fairy Frequency Fairy Frequency 4 years ago Atophagy... fascinating information. Thank you. Wishing you an amazing week x) 5 Reply Rakesh Ganne Rakesh Ganne 1 year ago (edited) This is in practice from thousands of years in India On 21st of every month according to indian calendar called Ekadashi or sometimes every fortnight...we are not supposed to eat Even today most of Indians practice this But things need western approval,you know🙃 2 Reply Lee Yy Lee Yy 3 years ago I'm a vegetarian, but when people asked me how my body can be so tall and big while not eating meat, I don't know how to explain despite some research efforts, taking vegetable protein like beans and broccoli, or genetically similar to my grandfather who also tall in size I only can say. Now I understand why. Reply sandybee sandybee 4 months ago ~This fasting really works...so glad to know this info. Dr. Fung is fantastic also. Reply Vivek Tonapi Vivek Tonapi 2 years ago Our ancient Indian sages knew this way before, creating the age-old tradition of Ekadashi, where you fast on every eleventh day of the month. 👍 1 Reply team ginate team ginate 3 years ago The more you fast the easier it gets. Once a week is good. Two consecutive days a week is better. 2 Reply ph0ib0s1 ph0ib0s1 4 years ago The important part missing here is what Insulin does to your body. All this fasting does not work, if you stick with carbs and sugar addiction. Trying to fast and loosing wight is a torture, if you don't remove carbs from your diet. Something also not mentioned here, consuming high level of proteins is similar to eating sugar. Your liver makes sugar out of proteins. From personal experience, switch to Keto for at least 3 weeks, fasting becomes very easy and the cravings for food, after loosing wight go away. If you stay addicted to sugar while fasting, you will gain all the wight back. Once you happy with your wight, feel freed to choose any kind of diet you like. 8 Reply 1 reply redrock1963 redrock1963 4 years ago I have always had a very quick metabolism. I can eat what I like when I like and I don't put on weight. (for all who say...."lucky you" It also means I lose weight and struggle to put it back on. I also have hypoglycemic "episodes") My point is, does this mean that my body goes into autophagy quicker than normal because it "starves" at a quicker rate? Reply Tazzzie333 Tazzzie333 4 years ago How does this process change when someone works out or if they have a very active job. For example, a person who is on their feet 8 hours a day and walks for most of it. Skipping a meal is very tough and not to mention if someone wants muscle definition then reducing your meals will definitely eat up muscle mass. Reply Simon Evans Simon Evans 3 years ago What's the difference between fasting, C.R and starvation? 2 Reply TrickyAP Ashish TrickyAP Ashish 3 years ago Type of fasting -24 hour fast -Alternate day -Skipping meals -Dailly window fasting ( 8 hour ) -Water fasting ( juice optional ) 25 Reply 4 replies Tyrone biggums Tyrone biggums 3 years ago I only fasted for 3 days I suffer from cronic allergies and rashes all over my stomach and back, now i’m clean thanks to fasting, i obly fast 48 hours a week now, I highly recommend this people suffering from things that you may not be aware of. Reply The Engineers Build the Future The Engineers Build the Future 3 years ago Verily Allah prescribes fasting to all Muslims. Allah knows whats good for the people. Fasting during Ramadhan is a blessing and a mercy. 😊😊😊 8 Reply 1 reply Johny Relax Johny Relax 4 years ago very well done video! Reply Rajeev Bhatnagar Rajeev Bhatnagar 2 years ago Fasting is integrated into Hindu and Jain religion. Especially in Jainism, some even today keep long fasts - seven days water only. I personally do not do but some of my relatives do. And they remain perfectly fine. It is practice on which there is no book but learned from generation to generation. 1 Reply Jacq low Jacq low 3 years ago I tried the 16/8 fasting, but it take a whole lot of discipline. In the end I gave up. 2 Reply 1 reply Venkatesh Bagal Venkatesh Bagal 'Self-Eating Cell' Research Wins Nobel in Medicine Wall Street Journal 4.11M subscribers Subscribe 11K Share 905,580 views Oct 3, 2016 Yoshinori Ohsumi was awarded this year’s Nobel Prize in Medicine for his discoveries of mechanisms for autophagy – a study into how cells detoxify and repair themselves. Subscribe to the WSJ channel here: http://bit.ly/14Q81Xy More from the Wall Street Journal: Visit WSJ.com: http://www.wsj.com Follow WSJ on Facebook: http://www.facebook.com/wsjvideo Follow WSJ on Google+: https://plus.google.com/+wsj/posts Follow WSJ on Twitter: https://twitter.com/WSJvideo Follow WSJ on Instagram: http://instagram.com/wsj Follow WSJ on Pinterest: http://www.pinterest.com/wsj/ Don’t miss a WSJ video, subscribe here: http://bit.ly/14Q81Xy More from the Wall Street Journal: Visit WSJ.com: http://www.wsj.com Visit the WSJ Video Center: https://wsj.com/video On Facebook: https://www.facebook.com/pg/wsj/videos/ On Twitter: https://twitter.com/WSJ On Snapchat: https://on.wsj.com/2ratjSM 1,035 Comments rongmaw lin Add a comment... veesutube veesutube 2 years ago (edited) I'm sure there were many researchers in the past who have known about this in parts, but he was the first one to actually care and discover how it all ties together and explain it from beginning to end. kudos to him, he deserves his nobel prize. 160 Reply 5 replies S Yusuf S Yusuf 1 year ago Thank you doctor Ohsumi May god grant you the best of health and keep you young physically and mentally ative to continue with your great work. You clearly are an outstanding asset to mankind as a whole Best wishes and prayers for you. 40 Reply rolla rolla 4 years ago Appreciate you Mr. Ohsumi, for your contributions to the humanity. 38 Reply Teddy Teddy 2 years ago Currently on day 3 of a 72 hour water fast. I feel great, clear minded and very calm. My skin feels smooth, old scars are healing, autophagy is such a powerful mechanism for healing and beneficial on so many levels. 308 Reply 61 replies William Jayaraj William Jayaraj 4 months ago Excellent Research. Congratulations to the Nobel prize winner. 5 Reply Mostly Ear Training Mostly Ear Training 4 years ago Part of the reason I started fasting and it's been really life changing as far as my health. Forget dieting. Fasting. It works. 567 Reply 16 replies Stella Miguel Stella Miguel 4 years ago With proper control and manifestation, this discovery of Autophagy can be of wonderful contribution to good health and well-being... too much of it I think, is what we can see in the poorest of the poorest communities, where not by their choice they had to suffer long term hunger and as you can see their pictures of these unfortunate people, they are skin and bones... a proof to me of the nature of Autophagy uncontrolled. 29 Reply Author Satoshi Author Satoshi 1 year ago 24 hours from now, I'll be ending my 5 day fast! Congratulations self! 200 Reply 13 replies seyahtan24 seyahtan24 5 months ago Yup. Fasting is really effective for cleansing the body and rapid weight loss. Tried and tested. Our body needs it especially in our era of junk/garbage foods. It's even biblical that we need to fast. 17 Reply Carol Takahashi Carol Takahashi 2 years ago Very dangerous to not drink water while fasting. My girlfriend did this and ended up in the ER. Her kidneys were shutting down and the doctor told her she could have died. You must drink water. 20 Reply Leon Maliniak Leon Maliniak 3 years ago Having now listened to this video second time, there is a serious contradiction with other videos about how AUTOPHAGY might work in dealing with cancer . This video says at one point that it may PROMOTE cancer cell production whereas in many other videos other doctors have said it can CURE cancer if you fast long enough...as discussed in the case study published by DR. ALAN GOLDHAMMER So, this must be cleared up on our beautiful Internet exchange venue. Can anybody clarify which proposition is correct ? Does AUTOPHAGY help or hinder in dealing with cancer ? 28 Reply 18 replies Spider Spider 6 months ago "Too much autophagy can promote the growth of tumor cells," did I hear that correctly? That isn't what other researchers have established. This is the reason you need to have a critical mind in today's society. 38 Reply 16 replies D. Robbins D. Robbins 5 years ago Excellent explanation for the lay person! 11 Reply Rohmad Abdulmaseh Rohmad Abdulmaseh 1 year ago I've been fasting since July 31, 2021.. so its been my 7th day of eating just once every 24 hrs. Thankyou, Professor 🙏 17 Reply 3 replies Twisty Soundy Sounds Twisty Soundy Sounds 1 year ago To all who were led here, may health, success, prosperity, growth be yours. Fasting, fasting, fasting, yes, it s an incredible strategy. Fast, you gain health, let the cells do their job 17 Reply SuckTitles SuckTitles 2 years ago I can't believe I finally have an excuse for being too lazy to eat. 175 Reply 4 replies susy dyson susy dyson 1 year ago activating autophagy is definitely the healthiest of ways to improve your life! 12 Reply Marie Loiseau Marie Loiseau 3 years ago 3 years later, the nutritional research which Ohsumi laid the groundwork for is all but forgotten by the public in favour of political veganism which promotes a dietary pattern dependent on an uninterrupted supply of low quality nutrients. Autophagy is, in context, a dangerous experiment on the human physiology where eating berries and fruit is the de facto standard of healthy living. 6 Reply 2 replies Kamal Nabiyev Kamal Nabiyev 2 years ago Hello Dr, thank you for sharing such useful and interesting information, could please advise, i am suffering from biluribin disease, Gilbert Syndrome. Is it ok if i do long term fasting as you proposed. Thanks in advance. 4 Reply ジェルリn ジェルリn 4 years ago He’s genius, now i know why fasting is really good for our health, now I’m starting doing intermittent . 54 Reply 7 replies Bailee Bailee 1 year ago I would to talk to this doctor about religion it would be soo fascinating Reply Prof. Michael O. Zeee JCD ECS Prof. Michael O. Zeee JCD ECS 6 years ago congratulations, Yoshiniro San! 111 Reply 2 replies M Zeeshan Iqbal M Zeeshan Iqbal 4 years ago Congratulation on great Discovery 👏 1 Reply FATIMA SANI FATIMA SANI 6 months ago A I started taking the medication I bought from Dr odija channel on YouTube and surprisingly it was working gradually and in 9days everything changed . I am really happy that you cured me naturally and I pray that God strengthens you Dr odija.. Reply Popa Alexandra Popa Alexandra 1 year ago I read through the comments that every religion has it's own way of fasting, for example I'm orthodox and we should fast Wednesday and Friday every week. I was ignoring this, I thought it has nothing to do with health....and here I am realising that fasting is the best healing tool for human body, it's a pity that society nowadays does not promote this, instead they push you take medicine for everything. In Romania for example there are pharmacy's EVERYWHERE! one next to other...it looks like it's a very profitable industry. We need to take care of our self so we won't end up on their hands....sorry for my English. 7 Reply PATRICK OKON PATRICK OKON 3 months ago Gratitude to you Dr Gboya on YouTube may God continue to bless the work of your hand as you continue helping people......... Reply djh djh 2 years ago I've limped around all summer with plantar fasciitis. I have tried fasting 24 hours, and it did not help. I fasted 48 hours, and it feels 70% better. If I had only tried that months ago!! I'm going to fast 48 hours again in a week or so. If you are in pain, give a longer fast a try. 86 Reply 4 replies anuj upreti anuj upreti 6 years ago congratulations sir! 8 Reply iin inayat al hakim iin inayat al hakim 1 year ago I am very happy with autophagy. This is very important. I feel fresh in the first day intermitten fasting 1 Reply 2 replies Taranjeet Gill Taranjeet Gill 2 years ago Thanku dr . 🙏🙏🙏🙏🙏 Reply ABDULLAH ABDULLAH 4 years ago (edited) For those who do wants to fast can fast along with the month of Ramazan every year, may be they are from other religion but for personal gain u can, but know ur time zone in upper Europe it's about 22 hrs of fasting, in middle east 16 hrs of fasting, in general it varies from 11 hrs to 22 hrs (Norway Finland Germany Russia Sweden Poland 22 hrs of fasting) yuroshima have wrong info of duration it's not 9-10 hrs it's about 11 - 22 hrs 12 Reply 1 reply Rachel Gapasin Rachel Gapasin 3 years ago In the Bible fasting is written as well 2000 years ago looking now it really has a good effect on the body when in fact it was promoted for Christians 20 Reply Huckle Berry Huckle Berry 4 years ago I'm a water faster and I do IF. I looked up autophagy on wikipedia and in the section related to cancer it says it can help with curing cancer , but it also says it can make cancer stronger. I'm confused can somebody explain please. 7 Reply 2 replies leafy leaf leafy leaf 1 year ago Alhamdulillah for being a Muslim who's instructed to fast by Allah Subhanahu wa Ta'ala 4 Reply 1 reply Meet The Kenais Meet The Kenais 3 weeks ago This has been known for ages by multiple civilizations 1 Reply ミレンラザロフ ミレンラザロフ 6 years ago well done 4 Reply A cat with black glasses A cat with black glasses 1 year ago Indians be like : we're doing it for thousands of year. 17 Reply 78Mkv 78Mkv 7 months ago I’ve been fasting since 2018. Sending this from 6ft underground. Luckily they still have reception here. Reply 333 333 1 year ago So, too much autophagy may have undesired effects in cancer where autophagy can promote the growth of tumor cells and the resistance of anti cancer drugs? 🤔 I would rather take my chances with autophagy over Anti cancer drugs any day. Autophagy kicks anti cancer drugs to the curb. My guess they had to word this way, for if they did not, they would be out billions of dollars in anti cancer drugs. 29 Reply 3 replies Shrijit Mazumdar Shrijit Mazumdar 2 months ago I ve started following autophagy rules on daily basis Reply Techie Fan Techie Fan 2 years ago To cure cancer, what should you consumer during a 3 to 5 day water fast? Just water only, or syould you take salt or portassium supplements? Will these supplements not keep the fast and its health result from reaching its full potential? 3 Reply 5 replies Anthony Anthonov Anthony Anthonov 5 years ago simple and genius 1 Reply Qwalion Busby Qwalion Busby 4 years ago I caught the end where seemingly it was forced "autophagy can cause tumor cell growth." I'm going to make a video about this topic on my page. Just gathering here and there the research. 4 Reply 4 replies The Renaissance Man The Renaissance Man 1 year ago Indians have known and observed the concept of "vrat" for thousands and thousands of years. These days, a vrat is popularly known as intermittent fasting. 5 Reply 2 replies Edward Dunn Edward Dunn 3 years ago Autophagy would have been the natural order for primitive man when we were hunter-gatherers. Food wasn't always available so a natural fasting would have taken place until the next hunt was successful and the high fat feast was on! Modern man has become so lazy with 24 hour drive throughs, you can just see the affects in the US and it's spreading across the planet. 6 Reply Priyanka Rathod Priyanka Rathod 2 years ago Omad fasting helps my skin a lot my acne gets better and oily skin becomes normal 117 Reply 15 replies Road Runner LAVA Road Runner LAVA 4 years ago Another man achievement is an burden to all students to remember his name ,age ,born place .. Reply Brittany Storey Brittany Storey 1 year ago you would think that WSJ would make a video accessible to people with hearing disability. Please add your own captions to your educational videos!!! 2 Reply Robert Heffner Robert Heffner 4 years ago ...she seems uncomfortable saying that too much autophagy may hinder the effects of using anti-cancer drugs... 34 Reply 3 replies Anurag Karanjekar Anurag Karanjekar 2 years ago Our Culture has important role of fasting throughout the time and now others know why! 14 Reply winterfox x winterfox x 9 months ago Anyone have more info on how fasting could cause chemo resistance or encourage cancer growth?? I have read it’s the opposite so I’m confused by that. 1 Reply 2 replies Ben CyBer Ben CyBer 1 month ago (edited) 👌 fantastic 👏 Noble price 1 Reply Tomyris Ruqiya Rukhaniat Tomyris Ruqiya Rukhaniat 1 year ago The question is that can cancer cells starve to die by prolong fasting or autophagy? and can a person with cancer cure completely? 1 Reply 8 replies Cynthia Trahan Cynthia Trahan 6 months ago Will autophagy help skin laxity? 1 Reply satya kvs satya kvs 2 years ago (edited) This matter was told by Indian Hindu ancestors in vedic period. that is 'EKADHASI FASTING', this occurring in every 15 days, i mean 2 days in a month. Indian master's don't need world recognition and personnel achievement ,they just want peoples happiness , today's modern world is running for that. i think world must know about Indian cultures those are good and healthy for today ' s life style. i don't want to criticize anyone ," this man did a great job" but iam just saying about my great culture. 4 Reply Sally Cha Sally Cha 1 year ago Fasting is not always good because your body needs glucose. In order to self produce glucose, your body has to go through gluconeogenesis and produce acetone. Acetone is a chemical which is not good for your body. 1 Reply 1 reply Thomas Traynor Thomas Traynor 1 year ago I am going to start a fast from now. I have shingles really bad for 4/5 weeks. I am not happy taking painkillers or any meds if I can avoid them! This viral infection is attacking me from my inside and now I need to try to eradicate this as I have read that some people can have ongoing pain with this shingles virus. I don't want to be one of these people and feel this is worth a pop. I am feeling so positive about this and will update in a few weeks - see how it goes. 2 Reply 1 reply Sankaravelayudhan Nandakumar Nandakumar Sankaravelayudhan Nandakumar Nandakumar 2 years ago Does this mean that the corona virus will also disappear in course of time based on cell eats its own cell. 2 Reply 1 reply ogulcanmdev ogulcanmdev 1 year ago This is a method used by Muslims for centuries. It is called "Oruç" means fasting. Today, because people like to live comfortably, it is a method that has disappeared from our lives, but is culturally living. 2 Reply Poquito Vibes Poquito Vibes 1 year ago Now I have a better answer to give someone when they ask me why I appear so young 1 Reply Vamsi guntupally Vamsi guntupally 2 years ago In India, Since many years we do fasting once in a week. 56 Reply 18 replies Ben CyBer Ben CyBer 1 month ago in FASTING : -- can choose 😉 1) dry fasting, without water & food 2) fasting , with water , without food choose the 1 that suit u cheers to everyone 🎉👍 Reply CAUTIOUS1 CAUTIOUS1 5 years ago Yoga masters knew and used this thousands of years ago. It's good that modern medicine will have difficulty arguing against it. Now that it's out 11 Reply 2 replies Swati Laggawar Swati Laggawar 3 years ago Is this autophagy mechanism can done in human being also. If yes how? Mr. Ohsumi Sir had mentioned there about the yeast cell only know. Reply 1 reply δlieř δlieř 1 year ago that ending is BS though 2 Reply vikaspersky antivirus vikaspersky antivirus 4 years ago goes a long way 1 Reply P. Santos P. Santos 3 years ago What's too much autophagy ? How long after we risk to get cancer ??? Now I'm confused... 13 Reply 10 replies Yonatan Endalkachew Yonatan Endalkachew 4 years ago Thanks Jesus for for showing us the way to fast and pray! 16 Reply Suka Laksa Suka Laksa 5 months ago That’s why in Islam, once a year we must fasting from sunrise to sunset. Min is about 12hrs in certain countries. Alhamdulillah. Reply Geeta Nambiar Geeta Nambiar 4 years ago THE NOBEL PRIZE FOR AUTOPHAGY WENT TO A JAPANESE IN 2016 FOR AUTOPHAGY--WHILE THIS IS WRITTEN IN CHARAKA SAMHITA 6200 YEARS AGO 2 Reply Ayesha Shaikh Ayesha Shaikh 4 months ago As a Muslim i believe that the best autophagy is done between sunrise to sunset. Not too much, not too little. 1 Reply 1 reply seven Rivers Rummi seven Rivers Rummi 5 months ago 100% SURE BEST information GooD knowledge Amzing RESULTs in my life. Reply HAYYA ALAL FALAH HAYYA ALAL FALAH 4 years ago I love fasting..and rewards 27 Reply Luis Felix Luis Felix 4 months ago Ahhh,,, very interesting? Getting older and watching our bodies "breaking down" to enter continuing "death cycle" hoping to add minutes to life.... Our "doomed to death" physiology is fascinating!! A conscious being understanding that existence is held by a thread not knowing where, when, how, and why we are is stronger than tangible self. Reply Anton Yang Anton Yang 4 years ago Thank you the one and only GOD, JESUS! 9 Reply Rob Sweeney Rob Sweeney 1 year ago I think she said too much autophagy causes the growth of more cancer tumors Reply Fun to Watch Fun to Watch 3 years ago Thats the benefit of fasting in Ramadan whatever Allah orders its for the betterment of human life proud to be a believer of Islam may Allah bless every human 6 Reply prashanth kumar prashanth kumar 1 year ago Autophagy means upavasam its common in india only Reply अतुल अतुल 3 years ago Hinduism is great more than five thousands year ago hinduism practice fasting with spiritual reasons, i proud to be a hindu and born in a hindu dharm 26 Reply 2 replies Raso Wye Raso Wye 4 years ago Eastern religions mainly Hinduism, Jainism, Buddhism advised fasting from thousand of years primarily for spiritual progress. Mental and physical benfits are just secondary outcomes of it. Mainly in Hinduism even now most of the people fasted once in a month compulsorily called 'Ekadashi'. Ancient Rishis, Seers and Spiritual Masters knew this scientific aspect way before this recent discovery. 10 Reply Assia d'Alger Assia d'Alger 2 years ago الحمد لله على نعمة الإسلام 2 Reply روز شيخ روز شيخ 5 years ago حثنا نبينا محمد صلى الله عليه وسلم على صيام يومين من ايام الاسبوع وهما الاثنين والخميس لذلك المسلمون الذين يصومون الاثنين ؤالخميس هم اول من حصلوا على هذه الفائدة 8 Reply Dendi Taegi Pionedi JendePo WINSI KAMEI Dendi Taegi Pionedi JendePo WINSI KAMEI 3 months ago If you take that much, you give them back that much as well 😢. Reply Tanmay Sakhare Tanmay Sakhare 3 years ago We know ekadashi fasting which is mentioned lakhs of years ago in indian hindu Vedas! 29 Reply 1 reply Reez A. Sam Reez A. Sam 2 years ago express our gratitude to God because he knows what's best for His Creation, via fasting! 13 Reply ポカフェス ポカフェス 1 month ago Surprisingly Islam recommends fasting for 14 hours for a month every year Reply Musa Patır Musa Patır 4 months ago Profesörün kitabı olabilir yani. Reply khurshid muhd khurshid muhd 4 years ago (edited) Thanks almighty ALLAH You have really bestowed upon US Muslim especially, made mandatory ONE Month fasting,(the Month of Ramadan) , through Prophet Muhammad SAW, which was revealed to Prophet Muhammad SAW 1400 years ago, now it is recently discovered by scientists just tow years back . It is a clear signs for NON-MUSLIM as well to think WHO is the Sustainer, The Creator of the Universe and to Whom we return to and on the day which we all will be resurrected again......May ALLAH SWT guide US all in the right direction .Ameen Ya Rabul AALAMEEN. 8 Reply 1 reply Generic Developer Generic Developer 2 years ago Yeah I'm pretty sure it would not be bad for tumors 1 Reply Bruna B. Bruna B. 2 years ago Autophagy can promote the growth of tumor cells? I guess it's the opposite. I will search for his original research, since the English of the video isn't very good and there might have been some misunderstanding. 3 Reply 2 replies ravinder bhardwaj ravinder bhardwaj 4 years ago Fasting in Hindus common in their culture one of the greatest religion in world Hindus. 3 Reply 1 reply ravinder bhardwaj ravinder bhardwaj 4 years ago Every week twice fasting in Hindus.and in festival Durga Puja 9days fasting in Hindus.very great culture 7 Reply 2 replies Train At Home Train At Home 2 years ago 👍👍👍 Reply Legalite & Tongue Legalite & Tongue 4 months ago At the end, she is actually saying that too much autophagy promotes the progression on cancer cells. Meaning that starving to death doesn't cure cancer but on the contrary! Reply WastingMyLifeInGlasgow WastingMyLifeInGlasgow 1 year ago 👏 Reply Bijoy Roy Bijoy Roy 3 years ago FASTING IN AMABASYA, PURNIMA, EKADASI, NABRATRI, IS THOUSANDS YEARS OLD RITUALS IN HINDUISM. 5 Reply zulfikar Shaikh zulfikar Shaikh 4 years ago perfectly Allah had ordained us fasting which does the job of autophagy . One of the greatest physical benefit of fasting is it prevents cancer.. 11 Reply 1 reply Augustus Augustus Augustus Augustus 4 years ago the most intelligent way of fasting you will find it in the Christian Orthodox Church . 7 Reply 5 replies Cynthia Elese Van Dyke-Melchor Cynthia Elese Van Dyke-Melchor 2 years ago Thanks 😊 Reply MD SK HABIBULLAH MD SK HABIBULLAH 3 years ago All praise and thanks is for ALLAH , who give us the month of Ramadan . 7 Reply joji varghese joji varghese 8 months ago Thanks for the video Reply Josette Eral Josette Eral 5 years ago My other Hero! 3 Reply Daksha Sheth Daksha Sheth 2 years ago In India, fasting tradition is centuries old. Ayurveda mentioned this long ago. 2 Reply 1 reply MrTHKhan MrTHKhan 1 year ago (edited) So here is the month of Ramazan, we here fasting the whole month. Thanks to Allah اللہ تعالیٰ. and our beloved Prophet Muhammad PBUH who tech us 1400 years ago. 19 Reply 3 replies lavender lee lavender lee 2 years ago 💐💐💐 Reply Nazia Fatima Nazia Fatima 3 years ago That's why creator almighty ordered us to fast minimum 30 days a year. Everything islam teaches is best for humans 8 Reply 2 replies Js Lang Js Lang 2 years ago So how would you no if your getting to much autophagy? Reply LORD VOLDEMORT LORD VOLDEMORT 1 year ago (edited) Ramadan Mubarak brothers and sisters ❤️ 19 Reply 15 replies Ajshdh Dhfhdh Ajshdh Dhfhdh 4 years ago It's amazing of how the Quran and the sunna of the prophet Mohammed (PBUH) words are followed are always wisdom advice for the humanity. Almost everything He said have been proven to be good for humans. Even the tooth brush (aka miswak in Arabic). It's sad that the Muslims didn't give this researcher a price for his amazing research! 3 Reply 2 replies Mubashir Javed Mubashir Javed 4 years ago Thanks Allah for ordering us of fasting 113 Reply 30 replies Emma Frost Emma Frost 1 year ago I did a 3 day dry fast but I had a panic attack . I’m kind of scared to try again. Reply 4 replies Daily Doze of Gaming Daily Doze of Gaming 4 years ago This is why ALLAH told us to fast for a month of Ramadan. I think when a scientist descovers such kind of things he must revert to Islam after discovering such a great sign of ALLAH which he granted Muslims.. Only then he deserved to call a great and wise scientist .. When he found truth he bows down towards his Creator 15 Reply 6 replies ALEX CIOCCA ALEX CIOCCA 1 year ago Ok I believe we have the proof but when I see an obese person walking up to a fast food restaurant and finding the door locks goes into a fit of rage kicking and yelling i want to take them home and tie them up in the basement for a prolonged fast because other then a catastrophic health event breaking their addiction is out of sight . Reply 🇷🇺Jesus Christ is Lord 🇷🇺Jesus Christ is Lord 2 years ago i fasted for 37 days. healed my body. Fin. 4 Reply 8 replies Diaa Eldin Muhammmad Diaa Eldin Muhammmad 4 years ago 1400 years ago, Prophet Muhammad Peace and Prayer be upon him taught Muslims a norm and tradition of fasting two days per week and said "Fasting, to be healthy". I bear witness that there is no god but Allah and that Muhammad is the Messenger of God. 35 Reply 5 replies sakib Mir sakib Mir 2 years ago That is why we Muslims fast durring Ramadan we don't eat food from dusk to Dawn Everything which Islam tells is beneficial for us 1 Reply Top Autophagy Benefits (Weight Loss) | Jason Fung Jason Fung 950K subscribers Join Subscribe 24K Share 313K views 1 year ago Autophagy is the natural cellular recycling process that rids our body of old or malfunctional protein. This sets in motion the process of rejuvenation as our body rebuilds new proteins to replace the old ones. Autophagy is a powerful method of healing and is best activated by fasting. Check out my blog at https://medium.com/@drjasonfung … Shop the Jason Fung store The Fasting Method Print IPhone Case iPhone Tough Case $16.99 Spring fungster Premium T-Shirt Premium Tee $24.99 Spring Fasting Method Print Premium Tee Premium Tee $22.99 Spring TFM Mug (Fasting Method Print) Mug $12.99 Spring TFM Mug (Fasting Method Print) Mug $12.99 Spring fungster Premium T-Shirt, Black letters Premium Tee $24.99 Spring 985 Comments rongmaw lin Add a comment... Jason Fung Pinned by Jason Fung Jason Fung 1 year ago Check out my video on how to lose that vacation weight - https://youtu.be/r1pYdK8T-po 42 Reply 12 replies Not Today Not Today 1 year ago I’ve recently realized I can fast for 72 hours. It’s like finding out you have a superpower. 438 Reply 54 replies PG JC PG JC 1 year ago I lost 90+lbs this year without any loose skin because of autophagy. 72 hrs fast and carnivore refeed. Thanks Doc! 567 Reply 56 replies john c john c 1 year ago Thank You Dr. Fung. I have been intermittent fasting for almost two years now. I try to tap into autophagy every few month or so. I have lost eighty lbs and kept it off for well over a year now with no problems at all. You have changed my life. 186 Reply 2 replies Marie Cherrilynn Tan Marie Cherrilynn Tan 1 year ago (edited) Been doing OMAD since March this year and my body has never felt this great ever before! Just finished my 36 hour fast yesterday, and my body and mind feels so refreshed and clear.. 188 Reply 9 replies Fat Lives Matter Fat Lives Matter 1 year ago Love the Fungman ! He Enlightened the heck out of me and I share his videos with anyone that shows me they are serious about living longer and feeling better. 54 years old and was 246 @ 5'9" now 167 and feel like a kid again ! Out splitting wood and climbing tree's, Who knew ? This guy did ! He got me started and gave me hope when I was in a ton of pain ! No longer ! 82 Reply 2 replies Xareny Canales Xareny Canales 1 year ago I’ve been doing 17 hrs a day of fasting for five days and I’ve lost one inch off my waist. My energy levels and mental clarity is amazing nowadays. I’ve been prediabetic and have hypertension for a few years already. My blood sugar levels and blood pressure have been normal the last few days.. I just wish I had found these videos years ago! 42 Reply 1 reply Virginia Darling Virginia Darling 1 year ago Dr Fung you really know how to break down material and simplify these concepts. I now understand the value of autophagy. Excellent presentation ! I hope to see more short videos soon. Keep up this important work! FYI Since I have been intermittent fasting and focusing on a low carb life style I have lost those last 10 lbs of stubborn fat! 233 Reply 2 replies Mark Herald Mark Herald 1 year ago I started experimenting with fasting 7 days ago. Monday I did one meal no carb. Same for Tuesday. Wednesday and Thursday I did a Water fast 48 hours, and back to one meal for Saturday and Today. I can tell you there is something happening to my body and mind. I have lost several inches in my waist and I feel great. My mind seems to be more clear. Pick your hard folks. It really is that simple. Doc I have watched your videos and been educating myself about fasting and Autophagy 63 Reply 3 replies Jason Evans Jason Evans 1 year ago I'm grateful for excellent vids like this where Dr. Fung does a nice job of explaining the science behind the benefits of fasting that help keep me motivated. After yrs of plant based/standard caloric restriction, the drop in body fat composition & increased energy with fasting/keto is astonishing. 93 Reply Rae Crisos Rae Crisos 1 year ago Autophagy is really powerful. I lost nearly 95% of chronic inflammation lower back pain, back pain that has been lasting for over 3 years. After refeeding I'm still not returning back to the usual but in a healthier state. Other than that, my liver biomarker has improved drastically by 50% from an advanced fatty livers. 219 Reply 13 replies Cosmostraveler 84 Cosmostraveler 84 1 year ago I’m 70lbs overweight but I’m on 18:6 fasting already lost 6 lbs in 5 days! Thanks Dr!! 31 Reply 3 replies Dwight White Dwight White 1 year ago Dr Fung explains things so easily that even I can understand it. Dr Fung you rock sir. 58 Reply D K D K 1 year ago What up, Dr Fung?! Still fasting m-f and OMAD on the weekends, eating whatever I want 💙 weight still coming off and only getting healthier. Thank you for truly saving lives 131 Reply 10 replies Sybil Sybil 1 year ago Thank you Dr. Fung. God is using you. You explain things so well. I really appreciate this video. Blessings to you Sir! 48 Reply malsamhill malsamhill 1 year ago I want to Thank You Dr. Fung I found one of your videos on fasting and the biggest losers 1 year ago before I was going in for a surgery. Started fasting worked up to one meal a day went from 240 to 190 at 5’11”. I turn 60 in a month my goal now is to get to 185 the same weight I came out of high school at. Doing this for a year with no problem I think proves to me I will do this for the rest of my life. Could not have done it without you and Dr. Ekberg love him as well. Thanks Again 22 Reply 1 reply Sam Larner Sam Larner 13 days ago Did my first fast last week and honestly, after the first 24 hours, it wasn't too hard. I surprised myself and fasted 56 hours in the end. Definitely want to practise fasting more now Reply Cathy Joe Nganje Cathy Joe Nganje 1 year ago As always, brilliant content. I have learnt alot from your teachings. Its making a difference in my life. Losing weight on IF 18/6 and re-dicovering myself is an exceptional feeling. Still on the journey. Thank you and please keep the videos coming. Short and straight to the point. Nothing beats that. You are truly human. Wish there were many more like you. 11 Reply Mandi L. Mandi L. 9 months ago Sometimes your body just tells you what it needs, fasting the second day in a row now without feeling hungry. Was concerned first but I'm energetic, happy and clear minded. 9 Reply Rosi Rosi 1 year ago I agree with all the comments. I feel 1000% better after incorporating a fasting lifestyle. Whenever I need to check in or fall off, I always find the answers in his videos. He has a gift for explaining complicated processes in a simple way 4 Reply MR Stoner 2udude MR Stoner 2udude 1 year ago I was struggling w fasting until i increased seasalt in water. Now very comfortable. Down 30 lbs in 8 weeks. TY Drs Fung, Eckberg, Berg 100 Reply 12 replies v a s v a s 1 year ago I have absolutely no idea what autophagy has done for me but I’m gonna continue as I know it doesn’t harm. I’m 66 and fat adapted so I fast 41 hrs twice a month with a goal of 48 hrs. I really enjoy OMAD. 42 Reply 2 replies Anxiety Anxiety 1 year ago Thank you Dr. Jason Fung! Me, my sister and my gf just started doing intermittent fasting because of your teachings and it's been amazing since then! I'm sure this will change our lives much more than I expect, I owe you big!! 17 Reply Jess Jagpal Jess Jagpal 1 year ago I'm on my day 1 of 7 days fast. I've done 3 days fast before. This will be my longest. looking forward to all the benefits I will experience both physically, emotionally and spiritually. 9 Reply sam macaskill sam macaskill 1 year ago Many thanks for your knowledge, time and energy. I'm fasting for Ulcerative Colitis. After 18 months of being in and out of hospital, I've been told by my consultant that I don't need to go back to hospital for a year. I work to heal my body. No amount of thank can thank you enough. 🙂💚🙏💜🙂 13 Reply Joyce Williams Joyce Williams 1 year ago I can only say THANK YOU DOC. I just can't tell you how much I appreciate you 142 Jason Fung Reply Derek Traise Derek Traise 1 year ago Such an excellent explanation! Glad you are bringing into the public knowledge. Sadly it won’t be promoted in mainstream because they can’t make money from people fasting. 6 Reply Lindsay Williams Lindsay Williams 1 year ago Dr Fung is one of the people I trust most on youtube. He always provides sources for information. 9 Reply opinions 123 opinions 123 1 year ago ever since I follow your utube on intermitten fasting and reversed diabetic 4 months ago. My a1c being reduced from 7.1 to 4,9 and lost 20kg (44 lb) . I have to say THANK YOU Dr Fung.❤️ 8 Reply dauntless bonita dauntless bonita 1 year ago Hi Dr Fung thank you for continuously advocating on fasting. Learned a lot from you and been implementing fasting regularly which helped in my overall health. 19 Reply TAV V TAV V 1 year ago i'm learning so much from your channel! i started fasting 3 weeks ago and already down nearly 10 lbs.. will keep at it long term... Thank you Dr. 6 Reply 1 reply Rafael Garcia Rafael Garcia 1 year ago Did 48hr fasting and feel fantastic! My blood sugar was 101!!!! 9 Reply Michelle Archuleta Michelle Archuleta 1 year ago You're so brilliant Jason, love the analogies with the images. Thank you! Breaking a 7-day fast in this moment, great to see how it has benefitted my body! 27 Reply 1 reply Fairuz AHS Fairuz AHS 1 year ago Love your scientific explanations Dr Fung, it helps one to understand fasting is not only about feeling thirsty and hungry..but what happens during fasting that create wonderful gift of health and rejuvenation to one self. 6 Reply 2 replies Elaine K Elaine K 1 year ago Love your videos, easy to understand the science behind fasting. I like re-learning all this info from all the different angles, it keeps me motivated. 7 Reply g robles g robles 1 year ago Excellent as always Dr. Jason Fung. Always appreciate you and all the teaching you provide for all of us. Thank you 👍👍👍 10 Reply Fit Forties Fit Forties 1 year ago (edited) Starting a prolonged fast tomorrow @JasonFung - goal is 8 days. Recovering from Covid last 11 days so hoping autophagy will repair the damage Covid did to my upper respiratory system and digestive tract (nausea and throwing up were a part of my Covid illness). Thank you for great content and educating us on the benefits of fasting!! 5 Reply 1 reply Pamee Hanson Pamee Hanson 1 year ago Thanks for making this with simple explanation and examples. This seems a complex subject for non medical people can understand. I enjoy your videos and have been doing IF and learning more as I go along my weight loss since March 14 pounds 😂 without the “diet” struggles and one thing is my appetite has been reduced and I no longer struggle with trying to stop eating as I feel full and can just stop eating😱 10 Reply Charles Strouss Charles Strouss 1 year ago Jason... I don't know if you read these comments, but your videos have helped me a lot, and allowed me to lose a bunch of weight and get off insulin. I did have a significant medical issue this last week, that was related to my super low carb diet. I was going a bit crazy with sodium, adding salt to my eggs, and eating a lot of sausage. Also, a few spoons a day of salted natural peanut butter and cottage cheese, both of which are high sodium foods. It seems that all of this sodium made my BP spike and caused weird headaches.... Now that I've cut back the salt, and unfortunately started taking 40mg Lisinopril qd, things are getting under control... hopefully I can d/c or at least reduce the Lisinopril soon. Just a heads up to people who are going low carb... watch the sodium! 4 Reply Pat Fontaine Pat Fontaine 1 year ago I’ve been following you for almost a year, and I’ve seen almost all your videos. This one is by far the best: clear explanations in easy to understand manner. Thanks so much for posting! 10 Reply 1 reply L D L D 1 year ago you have changed my life over the past few years reading your books and watching your lectures. Thank you. 15 Reply Michael Dillon Michael Dillon 1 year ago I can't remember who wrote it but I once read ' that the best meal you can have for your health is not to have the meal ! ' . Probably it was a genius like Dr Fung 👍. 134 Reply 5 replies Vinicius Santos de Lima Vinicius Santos de Lima 1 year ago Has anyone here noticed you can eat less then before and feel full ? I was a rice vaccum, an animal, i could eat ridiculous amounts of food enough to get black listed in a all u can eat Chinese resto. Now after a month of OMAD every day and once a week 48h/water only when I break my fast with a little meal just to start I'm feeling full !!! It's amazing !! 125 Reply 14 replies Colleen Moras Colleen Moras 1 year ago I've been eating OMAD for a few weeks. So I decided to try a 36 hour fast. Well after completing 36 hours I pushed through and made it a 50 1/2 hour fast. Can't wait to do it again. Next time I'm going to go for a 72 hour fast. 15 Reply Karl Karl 1 year ago I've watched dozens of videos and read lots of websites that talk about autophagy, but this had a great balance of talking about the details of different kinds of autophagy without going into too much technical details about things that a layperson struggles to understand. It would be great if you could follow this video up with a technique video -- i.e. HOW to fast to achieve different kinds of autophagy for different goals. Looking forward to the next video. 7 Reply Batgirl P Batgirl P 1 year ago My 48 hr fast starts tonight. I'll be binge watching your videos for encouragement! 80 Reply 6 replies Mark Zambelli Mark Zambelli 10 months ago Thankyou Dr. Fung... you clear things up tremendously. My question is how easy is it to inadvertantly drop out of autophagy during a fast? I regularly fast for anywhere from 3 to 4 days up to 11 or 12 days and I feel amazing, have lost loads of weight and have 'cured' my painful wrist, thumb and left knee over the last 6 months. But, I drink one strong coffee in the morning, red-bush (rooibos) tea throughout the day and sip on 2 litres of 'Lo-Salt' water (KCl and NaCl) to stay hydrated. Has the coffee and red-bush (caffeine-free btw) been pushing me out of autophagy? Perhaps someone here might shed some light on this for me... I'd be very grateful. 2 Reply Drake Santiago Drake Santiago 1 year ago There should be a balance between breaking things down and building things up. That principle is applicable in biology and can be generalized to nearly everything in this world. Going too far to one extreme or another is the root of nearly all forms of dysfunction and unhappiness. Thank you Dr. Fung for being the foremost voice in emphasizing the need for such balance in our dietary habits way BEFORE it became the popular thing for diet gurus to advocate. 4 Reply Suneetha G Suneetha G 1 year ago With 50 days of 18-6 IF, in between one 24 hours fast and one 36 hours fast my fibromyalgia pains are totally zero and cholesterol levels are totally normal....... Still continue to work on hypothyroidism....... IF is very much effective to cure diseases Very happy to share my experience....... Hope It may help someone who is looking for motivation..... Keep going with IF Happy fasting ☺😄 7 Reply kabes7 kabes7 1 year ago Such an incredible bonus to fasting for weight loss. Would've liked to hear more specifics like how many hours you need to fast to get a good amount of autophagy. The app I use to track my fasting (fastic) says after 16 hours it begins, so I am I right to assume my normal 23:1 regimen is getting me autophagy every day? Lately I've been considering throwing in one or two 48-hour fasts per week since I am not hungry anymore, even at my mealtime. I enjoy eating a lot, but I don't have the physiological need after a 24 hr fast, it's all just for pleasure at this point. So why not try some 48 hour ones? Think I will skip my dinner tonight and see how it goes. 5 Reply 2 replies Maisie Maisie 1 year ago Thank you — you’ve no idea how much you have supported me x 30 Reply MissLRKindness MissLRKindness 1 year ago (edited) Found your videos, then purchased 2 of your books. You are amazing at explaining the processes of how our human operating systems work. By incorporating intermittent fasting, I have greatly benefitted mentally and physically. Sincerely, I appreciate your videos! Thank you. Reply Life of Mike Life of Mike 1 year ago This is what I love about the internet. This stuff is literally free. 167 Reply 9 replies Nigel Skelchy Nigel Skelchy 1 year ago Been doing OMADS and IF and periodic 48 to 72 hour fasts. Lost 13kg since April till now. So excited. Also feeling so much more energetic. Though the first day of extended fasts isn't the most fun! Reply Carlos Portillo Carlos Portillo 1 year ago Thanks for the explanation Doc! All your other videos on what type of hormones are trigged depending on what we eat has helped manipulate my metabolism to lose 25 lbs over 3 months! #Keto+Intermittent Fasting= metabolic flexibility 1 Reply Tyra Rice Tyra Rice 1 year ago I love the way you broke that down. I'm 52 years old, 5 foot 1 and need to lose about 80 pounds. I started intermittent fasting about a month ago for weight loss. I haven't lost any weight yet but my fingernails are back to being hard and sturdy after constantly chipping and breaking for the last 4 years and my energy level has gone up. I was a junk food junky for years and thought i would feel like I was dieing from starvation doing the 16:8 fasting but that didn"t happen. 6 Reply 2 replies Michelle White Michelle White 1 year ago Very informative! Beautiful explanation on how our digestive system actual works in order to obtain maximum health. Thank you so much! Reply DANA CAPERS DANA CAPERS 1 year ago I ABSOLUTELY LOVE LOVE LOVE THIS VIDEO !! THANX FOR THE EXAMPLES AND TAKING YOUR TIME IN EXPLAINING..YOUR ALWAYS GREAT AND APPRECIATED MR FUNG !! 😊 HAVE A GREAT WEEK. 9 Reply CHILD OF THE MIGHTY CHILD OF THE MIGHTY 1 year ago I appreciate you doctor. Doing my 36 hr fast starting now. I have learned alot from you. 4 Reply Vamsi Harati Vamsi Harati 9 months ago Thanks Doc for sharing such great content .. Really motivating and insightful.. 👍 Reply Cameron Kerr Cameron Kerr 1 year ago Really appreciated how mTOR and Insulin relate to protein and carbs respectively. When I was doing alternate day fasting I noticed that weight would steadily and slowly decline, then pause for a few days… while waistline seemed to shrink (but weight stayed the same). This cycle would repeat a number of time as I lost about 25kgs. So I’m wondering if the body has some mode whether it is burning autophagic debris or it is burning fat. Ideas? 2 Reply 1 reply Rashmi Rasadha Rashmi Rasadha 1 year ago Thank you DR Fung, please do a segment how fasting can effect in arthritis, severe back pain, joint pain. Appreciate 💐🙏 11 Reply Cloise Reyes Cloise Reyes 1 year ago I really appreciate your teaching to all human being...God bless you Doc 3 Reply William Berliant William Berliant 1 year ago Dr. Fung, I was having a terrible time with intermittent fasting. Every time I skip breakfast by lunch time my stomach hurts. This happened repeatedly. I figured that I just couldn't skip a meal. It doesn't work for me. Then, I discovered what the problem was. It wasn't the fasting that made my stomach hurt, it was the coffee. Even though I was skipping breakfast, I was still having a cup of coffee with heavy cream and butter. That helped me be full until lunch. But then my stomach would really hurt. I quit the coffee, now, no problem. I have no problem drinking water. Have you ever heard about coffee being an irritant when fasting? 1 Reply J. Adams J. Adams 1 year ago Thank you for this vid, and thank you for writing the book on fasting. I'm shedding weight, and feeling better. 6 Reply 1 reply frankie cutlass frankie cutlass 1 year ago Hello Dr. Fung love your videos! I keep hearing differing opinions on how long of a fast is needed to activate autophagy, can you definitively say how long and does it differ from person to person? Thank you for everything you do. Reply Lynn Campbell Lynn Campbell 1 year ago I fast 18-6 because I am diabetic. Have lost weight and A1C is down. It works! 13 Reply 5 replies Bo Lieve Bo Lieve 1 year ago Hi Dr Fung. Excellent advice. Thanks for the videos! 29 Reply Aro-Rat Aro-Rat 1 year ago Thanks Dr. Fung, very well explained as usual and very powerful. I'm on your cancer code book at the moment. 1 Reply Cande Carroll Cande Carroll 1 year ago So interesting! Dr Fung always mentions this but rarely goes into it in such detail. Thank you. Reply Sasha Sasha 6 months ago Exactly that! I feel like my body is like that avocado green outdated bathroom! I hope I manage to get into autophagy, I didn't think I'll have so many mental blocks about it Reply Walt Dupre Walt Dupre 1 year ago Thanks Dr. Fung. Really enjoy your videos. I am teaching a health course this fall, focusing on nutrition. Is there one book - yours or another authors - that you would recommend as a good overall companion to build the course around? Reply Mathieu Guillet Mathieu Guillet 1 year ago Excellent as always, sir. Thank you! 12 Reply Judith Oriali Judith Oriali 1 year ago Thank you as usual very helpful info. Great Sunday everyone. Freedom for 🇨🇺 27 Reply Ninez Gimony Ninez Gimony 1 year ago Very informative explanation from you, Dr. Fung. More powers. Reply Ochiai Roma Ochiai Roma 1 year ago I lost almost 5 kg for OMAD except Saturday and Sunday for almost two months. Thanks Dr. Jason Fung for the details. 2 Reply Fruit Lover Fruit Lover 1 year ago Hi Dr. Fung do you mind to share your thoughts on exercise in the morning while intermittent fasting? Should I schedule my workout close to eating time or non fasting time? Thank you so much!!!! 2 Reply justchill79 justchill79 1 year ago I’ve been on OMAD for 3 years and on days I don’t do OMAD, I can’t even eat “bad” processed sugary food even if I want to. 44 Reply Mucefita Donelly Mucefita Donelly 1 year ago I shared with my family!! Everyone should know this. Thank u Dr. Fung. Reply ☀️Golden Goddess👑 ☀️Golden Goddess👑 1 year ago Absolutely love this breakdown. 5 Reply Pamela Chappell Pamela Chappell 1 year ago Such great information; thank you for taking the time to share with us. 4 Reply Isin Isin 8 months ago Thank you Dr Fung. Very informative video indeed. What is the minimum time we need to fast for autophagy to occur? Is 18 hours daily fasting sufficient for example or should we keep going for a couple of days without any food? 1 Reply 1 reply Sledge Hammer Sledge Hammer 1 year ago uhm i did continue to grow as an adult, I had a growth spurt sideways, not up. But thanks to Dr Fung, I'm Benjamin Buttoning this sideways growth. 19 Reply Robert Robert 8 days ago I’m a big fan! I have a quick question… Does autophagy stop if you consume a fat, like an avocado and or olive oil? 2nd, does it stop if you eat less than 20 grams of protein like 2 eggs with your avocado as a lunch before my normal OMADinner? Thank you & keep up the great work! Reply Aimee Paterson Aimee Paterson 7 months ago Thank You, Dr Fung. As Always, Very Informative!🌹 Jason Fung Reply Jason Fung · 1 reply sanskruti barot sanskruti barot 1 year ago I don't remember anything I learnt in biology in school except "MITOCHONDRIA IS THE POWERHOUSE OF THE CELL." 🤓 5 Reply John Goh John Goh 3 weeks ago Hello Dr. Jason, I have been following your Intermittent Fasting 16:8 protocol that 16 hours fasting and 8 hours eating window since 2019. According to another Fasting Expert, she said, quote "Yes, at 17 hours autophagy is slowly turned on and it will peak at 72 hours" close quote, since my fasting hours is only 16 hours, which is short of one hour, Autophagy does not kick in at all, right? May I have your comment please. Reply Heidi nails n’ stuff Heidi nails n’ stuff 1 year ago From 2010-2011 i lost 75 kilos doing calorie restriction. Worst years of my life where i ended up needing b12 and iron injections and doc considered me borderline malnourished. Yes i lost the weight, but i was not functioning. Sleeping 10 h a night plus nap during the day. I got praise for losing weight, but when i tried to tell them i didnt feel better, in-fact i felt worse, i was looked at like I was stupid. Losing weight is “good for you”, right? My son told me i had slurred speech and at times i talked in slow motion. I did not notice this myself really. And now we are talking about my maintenance period AFTER i lost weight. I could after a year maintaining that new weight, STILL not eat more than 1300-1400 calories a day, without GAINING weight. I got fed up and started eating 1600-1800 a day, and felt better. But weight slowly came back even tho i still kept an eye on calories. I was convinced my body was trying to get back to my highest weight and sucked up ever calorie i ate. Watching Dr, Fungs videos put words and scientific explanations to what i lived through. 3 years ago when i started keto to try lose weight again, i felt like a new person. OMAD came naturally due to less hunger, and i loved my “keto brain” as i called it when talking about it with others. I felt creative again for first time in years. I had less pain in the surrounding tissue of my hip joint(which is crocked), so i take less pain medication. I always struggled with inflammation in that tissue being irritated when i moved too much. I dont need codeine daily anymore. I now and then take keto-holiday where i dont count carbs, but it doesnt take long before i want my keto-brain back. Its my default “setting” now..living keto lifestyle with OMAD. Carby days are rare, and only for special occasions. After watching most of his videos i am now experimenting with longer fasting, and i have yet to exceed 36 hours. But so far i love how it makes me feel. So for an over-eater, like i have been since childhood..this is amazing. Hard to believe this is ME living like that. Love it. 4 Reply 1 reply Tamara B Tamara B 1 year ago Friend of mine told me about your channel I am glad she did, I love how you present your videos with awesome information 18 Reply Raquel Tran Raquel Tran 1 year ago You’re a very good teacher, easy to understand. Thank you so much.👍👍👍 Reply Kathleen McKeithen Kathleen McKeithen 11 months ago Thank you, Dr. Fung. I have only recently discovered your Youtube, and have subscribed. One of the many things I appreciate about your presentations is that you do not talk at the speed of light!!! I am able to take in and process what you are saying!! 😁 Reply Brian Kaufman Brian Kaufman 1 year ago Age 66, following Jason Fung OMAD strategy…….215lb to 193lb in less than 3 months…..13 more to target weight of 180…..feel stronger, more energetic, think more clearly…….and my kitchen counter is clean for 23hrs per day!!! OMAD is the best thing I’ve ever done for health…….really appreciate Jason Fung educational videos…. 16 Reply Paul Sargeant Paul Sargeant 1 year ago Great video Jason, I know all about autophagy I have been fasting now for over one year, 3 Reply logan spriggs logan spriggs 1 year ago Thanks for the great info! Your videos really help me spread good information. Reply MARIE MARIE 1 year ago This was so clear for me to understand. 8 Reply Encourageable Encourageable 11 months ago I’m 48 hours in to a water only fast and strangely I have not really felt hungry. Losing my voice though - not sure why that would be. I intend to do a full 5 days. Reply Radical Health Benefits of Autophagy Drbeen Medical Lectures 613K subscribers Join Subscribe 1.8K Share 22,559 views Streamed live on Sep 1, 2022 #drbeen #koolbeens #COVID How to activate autophagy now for better health? This question is most asked, and this topic is very researched. Let's review what we know so far. If you like this content and want more, I am doing a special lifetime membership offer. Click here: https://www.drbeen.com/yt-special-p/ Want to support this work?: Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeen... Become my patron: https://www.patreon.com/mobeensyed?fa... PayPal: https://paypal.me/mobeensyed?locale.x... My substack: https://mobeensyedmd.substack.com/ #drbeen #koolbeens #COVID Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. Dr. Ana Maria Cuervo, MD, Ph.D Macroautophagy starts within 30 minutes to an hour of starvation. When do we starve? In the intermittent fasting of 8-16. The macroautophagy starts within 8 hours if there are no snacks. The chaperon mediated autophagy occurs during the 16 hours. If you keep the 16 hours window including the sleep then the neurons are able to perform autophagy as well. URL list from Thursday, Sep. 1 2022 Yoshinori Ohsumi - Wikipedia https://en.wikipedia.org/wiki/Yoshino... HOW LONG Does It Takes To Activate AUTOPHAGY? | Dr Ana Maria Cuervo Interview Clips - YouTube • HOW LONG Does It ... Short-term fasting induces profound neuronal autophagy - PMC https://www.ncbi.nlm.nih.gov/pmc/arti... Autophagy: Definition, Process, Fasting & Signs https://my.clevelandclinic.org/health... 6 Signs And Symptoms of Autophagy https://www.healthline.com/nutrition/... How Long do You Have to Fast for Autophagy? – spermidineLIFE® US https://spermidinelife.us/blogs/news/.... How Long Do You Need to Fast for Autophagy? https://www.medicinenet.com/how_long_... Ana Maria Cuervo, M.D., Ph.D. | Faculty Directory | Albert Einstein College of Medicine https://www.einsteinmed.edu/faculty/8... Cuervo AM - Search Results - PubMed https://pubmed.ncbi.nlm.nih.gov/?term... The coming of age of chaperone-mediated autophagy - PubMed https://pubmed.ncbi.nlm.nih.gov/29626... Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) - PMC https://www.ncbi.nlm.nih.gov/pmc/arti... How to control self-digestion: transcriptional, post-transcriptional, and post-translational regulation of autophagy - PMC https://www.ncbi.nlm.nih.gov/pmc/arti... Chaperone-mediated autophagy sustains haematopoietic stem-cell function - PubMed https://pubmed.ncbi.nlm.nih.gov/33442... Molecular definitions of autophagy and related processes - PMC https://www.ncbi.nlm.nih.gov/pmc/arti... The different autophagy degradation pathways and neurodegeneration - PubMed https://pubmed.ncbi.nlm.nih.gov/35134... How Long Do You Need to Fast for Autophagy? https://www.medicinenet.com/how_long_.... Intermittent Fasting and Obesity-Related Health Outcomes: An Umbrella Review of Meta-analyses of Randomized Clinical Trials | Cardiology | JAMA Network Open | JAMA Network https://jamanetwork.com/journals/jama... ADULT NEUROGENESIS IN HUMANS: A Review of Basic Concepts, History, Current Research, and Clinical Implications - PMC https://www.ncbi.nlm.nih.gov/pmc/arti.... The 2016 Nobel Prize in Physiology or Medicine - Press release https://www.nobelprize.org/prizes/med... Chapters View all 170 Comments rongmaw lin Add a comment... D B D B 6 months ago As an R.N. I found this discussion to be a great review but also offer new information I hadn’t heard 20 years ago in school. Listening to you keeps me updated and informed. I appreciate your teaching style and your drawings! 11 Reply LLKool Bean LLKool Bean 6 months ago Excellent discussion Dr. Been. I do IF almost every day.and I gotta say, when my husband got COVID, I never tested positive for it. Never had any symptoms, etc... I really think it has contributed in strengthening my immune system. 36 Reply 4 replies David Coalkey David Coalkey 6 months ago I was experiencing brain fog after COVID. I started a keto diet and intermittent fasting and it fixed the brain fog. If I eat carbs again the brain fog comes back. 57 Reply 7 replies L Vee L Vee 6 months ago Excellent video Dr Been. I have been intermittent fasting to address chronic inflammatory issues and it's made a big difference. It's really useful to understand these mechanisms. You are a gifted teacher and explain things so clearly. 3 Reply Spencer Spratley Spencer Spratley 6 months ago Glad I discovered this channel. You put out some really excellent content. Thank you so much. 13 Reply Bob Thrasher Bob Thrasher 6 months ago (edited) If autophagy peeks at 48 hours, then what happens during extended water fasting? Short term "starvation" will enable cells to dump their waste (intra-cellular action), but we know that longer term starvation can break down things like arterial plaques and also "remodel" damaged tissues (extra-cellular action). It would be great to get the whole spectrum of what mechanisms are active over these various "phases" of "starvation." 38 Reply 18 replies Michelle Michelle 1 month ago Thank you for all you do. I’m very susceptible to all variants of covid. I had the first strain (devastating), then delta, then all the omicrons. I find that fasting helps me recover very fast from the omicron variants. I usually start the day with a coffee and eat dinner only. Or I eat breakfast, skip lunch and workout while hungry. Working out while hungry has been the fastest way to lose extra pounds. I feel comfortable in a bikini now and I’m loving it 👍 Reply Clives Clives 6 months ago Brilliant lecture and I love the drawings. Seems that autophagy is a newish field for detailed research. Your comments regarding the possibility for cells, responsible for immune response, to be cleaned out while cancer cells may thrive as a consequence, is very interesting. Are there any studies which lead you towards that possibility? I would like to kill off the bad guys but not the good guys! I have been following the work of Dr Walter Longo and his fasting mimicking diet. He also sees the benefits of autophagy and your lecture explains in great detail the mechanisms involved. 13 Reply 2 replies Paul Wolf Paul Wolf 6 months ago I've been on an 8/16 schedule for almost a year. Lost tons of weight (well, pounds anyway lol). Also, the weight loss has been synergistic with exercise and I have gotten into great shape at the same time. I am an avowed "breakfast skipper" and eat my first meal at 2:00 PM. I drink coffee all morning, also take NMN and other supplements. Last night I ate a big bowl of popcorn around 9:00PM and didn't have any problem sleeping on an empty stomach. You just have to make a rule for yourself not to eat anything before 2:00 PM. 1 Reply S Shannet L. Nielsen S Shannet L. Nielsen 6 months ago There is a great group at Facebook where we practice this. We are suffering from LC or postV syndrom. Also there is surveys you can answer during the process to get more information. I think its a very good and supportive group. The ones in charge do also a great work. Best wishes to everyone. ♥️ 5 Reply 2 replies Carol Lee Carol Lee 6 months ago DrBeen you be the bomb of medical education and brotherly love. Please more on this topic with case studies too! Reply LaM LaM 6 months ago Thank you Dr Been! You’re so helpful to us ordinary regular folk who need such explanations so as to take good care of ourselves, since our healthcare system and our family doctors have no such inclination, as it would make us healthy and thus reduce their incomes and profits from big pharma! So thank you immensely and God bless you! 1 Reply 🐞 ladybug 🐞 ladybug 6 months ago Thank you so much Dr been for this detailed clarification of intermittent fasting. AT first when I began it, when you first talked about this 4 months ago, my body immediately was happy and went into the mode of eating at noon and then not wanting anything until about 7. I did not know that I was not allowed to actually eat in between the first meal and the last meal but that was what my body wanted initially. MY body begin to shift after a couple months and I no longer felt simply the lack of desire to eat. SO I would take a sip of pineapple juice which I believe aids digestion and sometimes some fruit, although I actually never ate a proper meal in between the first and the last meal of the day. Of course the devil is in the details and now I know I better not sip or eat in between. OF course during the 16 hours stretch of no food I did sleep. I'm wondering how long one should sleep and maybe you will get to that but I'm guessing it's the usual amount of 7 to 8 hours. THIS is my last stop in trying to get rid of the continuing Cascade of side effects from the vaccine which began about 2 months after the vaccine. I've gone through a series of side effects for 15 months & the last one now is my skin is breaking out. Initially about 4 months ago I had a series of four times when my body would turn red and heat up REALLY hot and the fourth time it was as if it was burning and I almost fainted. I thought --Boy, I hope this doesn't carry on. I was at home so that was good. I read later that other people have had this side effect so I did not feel as scared from what might happen if it carried on & worsened. Instead it switched to a second skin side effect which Sean has talked about: I felt like I was being bitten by ants or some type of teeny creature and yet when I looked, there was nothing biting me. Recently that stopped and now I'm having the third skin side effect which I can only attribute to the Vax due to this series of things occurring to me. IT is a skin breakout. FIRST on my throat little bumps that had no color to them; then on my upper chest by my collarbone-- little bumps that had no color; and then a breakout of red bumps on my right side where my shoulder was and the collarbone and then it expanded to the left side so now my whole upper part of my body is covered with little bumps and they are visible especially on my left side of my shoulder and collarbone AND here I'm going to Florida🌊🏖🌦☔ for vacation! I know I'm saying-- Cry for me, NOT don't cry for me Argentina-- but because of monkey🐵 pox, I worry people will think I have 🐒 pox which can begin as a rash! 😳 IT'S been a month and definitely is NOT 🐵pox so I'm hoping that people won't look🙈 very closely & it will start to fade & if I go to the ocean every day and immerse myself for at least 1 hour in the salt water🌊 it will finally start to heal. I truly feel this is the third stage of the skin's reaction to the Vax & the body's way of detoxing. BY chance, I came across a place in County Sligo, Ireland where you can get seaweed baths that drain your body of ALL toxins in a very gentle but aggressive manner. I am thinking of going there if I can't heal my skin problem and am unable to detox on my own. It will be very pricey but i truly want this poison out of me!!😫😤😵 I do think the fasting helps but having heard the first part now of your talk, I think I NEED to do what I was instinctively wanting to do 4 months ago which is to increase it to 24 hours and then 48 hours. I will say tho that my body-- unlike at the beginning of my intermittant fasting several months ago-- does not REALLY want me to go without food so long so it will be a little tricky. I have taken the opportunity to write here on more than just fasting because I'm hoping someone else who has had the skin condition or knows of someone who does, can say-- DON'T worry, this too will pass and it is your body reacting to the Vax and trying to get the toxins that it created out of your body and this is the last step! I live in Texas and all summer it was 107° F and my AC was not working so I would be sweating in a 95° F home and then when I went outside it was 107°F and with great humidity. SO at first I blamed my break out on the extreme heat this summer and then later I figured it was both the vax and the heat but now that it's cooled off, I think it's just the vaccine side effect. SO m👼y blessed cool beens, if anyone knows of something similar, do tell. 🤗THX. AND of course I thank our dear Dr Been for all the work he does and the fact that he actually cares about people who are trying to heal.🙏🌠 4 Reply Skinscape Tattoo Skinscape Tattoo 6 months ago The more I watch you the more I love you. Your drawings are superb and you clearly have so much enthusiasm for your topics and research 3 Reply 365OutDoors 365OutDoors 6 months ago (edited) Doctor Been such wonderful information. For someone to integrate autophagy into their lifestyle you must understand the mechanisms of satiety, the state of being full, and prolonging that feeling. Current FDA guidelines on diet is calories in calories out model, whereas a better understanding would be the hormonal control of hunger and what to eat to prolong satiety without being hungry. The current MyPlate guidelines on meals eating will cause someone to fail on trying to practice autophagy. Hunger always wins. Hormones like leptin, grilling PYY, insulin and others are more controlled by eating a higher fat and lower carb diet. This would be a great follow-up lecture to this one you just gave. 7 Reply Barbara Fisher Barbara Fisher 1 month ago As always Dr. Been brings the greatest videos with so much information. Reply JG HK JG HK 6 months ago Thank you for what you do Dr. Been. 5 Reply Nena Nena 6 months ago Thank you 🙏🏻 I love your lectures. And I’m not even in the medical field. I wish I watched your videos before I decided what to study 📚 when I went to college. 1 Reply 1 reply Jennifer Everett Jennifer Everett 6 months ago (edited) GOD bless you for helping the public in this manner, and I pray that many will support your work financially!!! I am certain that Jesus, our creator, is pleased that you are generously sharing your knowledge to benefit others. 2 Reply Bob Henderson Bob Henderson 6 months ago Dr B we need more info on how to eliminate the spike protein from our bodies and what can we do to break it down - thanks 20 Reply 6 replies S Storm S Storm 6 months ago I think I have been doing this most of my life after the age of 16 or 17... Always had tons of energy all my life... I thought I was just being lazy about skipping meals..... Until I feel really hungry or a meal is offered conveniently.... 5 Reply Ernestine Johnson Ernestine Johnson 6 months ago I used to only eat once daily, yet feels energized. Slim and strong. People would said to me that I was too slim, I finally started eating 2/3 times a day, gained weight but feels more tired. I wish I've stuck to my original way of eating. Thanks for all information you gives. 13 Reply 2 replies GM GM 6 months ago What's the general timescale for autophagy? Various professionals have suggested 17 hours, 18 to 20 hours, 24 hours, some saying it can take days. Some even saying slight intermittent fasting can trigger autophagy. Reply Nichola R Nichola R 6 months ago I have been eating one meal a day for 3 years, occasionally I have a pie in the afternoon, otherwise no sugar, little fruit a ton of vegetables, pickles, eggs, beans, fish and wheat. That is what my body seems to love. I have no hunger; blood sugar seems to stay stable for 24 hours. I am 66 never been so healthy! So, the scientists just found this out, it has been known in the traditional health fields for hundreds of years. But I guess most of them were burnt at the stake. 2 Reply Kitten Mom Kitten Mom 6 months ago Thanks for the great info on autophagy, however life is hard enough without further torturing myself to gain few extra years to the geriatric end stage of life. As a coffee loving lacto-vegetarian I'm indulging the hot chilly and garlic saturated home grown chicory that supposed to promote health and prolong life span. 3 Reply shenmeowzo shenmeowzo 6 months ago Awesome talk. I want to try fasting to trigger autophagy to see if it helps with my vision, I have persistent floaters which I'm concerned might be the start of cataracs, I'm 43, pretty healthy, but need to cut out refined sugars. I'm willing to try anything to improve my vision. Might be a long shot, but have you seen any studies that suggest a benefit of this kind? 1 Reply 3 replies Maddie2019 Maddie2019 6 months ago (edited) Dr., I saw a special on a man that was given a 500-calorie-a-day diet for several weeks. He had cancer and they"starved" cancer. Can you address this? I have done the 16/8 and my doctor was soooo excited about the results. Also during this time when I did start eating I got diarrhea, have you heard of this? It was like when I ate maybe the insulin output was too great to digest the food. 2 Reply 877swissmiss 877swissmiss 6 months ago (edited) Loved this video😊, thanks!! I‘ve been doing that for a long time.( 1 meal a day- type) I think we all eat (western world) too much anyway and too often AND much unhealthy stuff..( processed food ) Reply Allen Cooke Allen Cooke 6 months ago (edited) I have two questions/comments: 1. During autophagy when metabolizing fat, does the brain not need/prefer glucose, so is some fatty acid converted to glucose? 2. I have read a number of anecdotal accounts of how fasting cured or promoted healing from advanced cancer, but Dr. Been said fasting is contraindicated for cancer due to wiping out immune cells that were fighting cancer allowing it to proliferate. 2 Reply 3 replies Lissu P Lissu P 6 months ago (edited) I skipped this lecture because I didn't know what autophagy is, thought it was complicated microbiology or something lay people don't easily get into. I'm so glad I came back to check it out. Really interesting!!! Maybe add a lay-friendly word in the title - if there are no click baits that we all click 😆 Reply John Brown John Brown 3 weeks ago What I've learned today Sleep while fasting. 👍🏽 love it Reply Laura Laura 6 months ago I learned this from Dr. Ken Berry and other keto/carnivore docs over 10 years ago. 7 Reply Jeannette Richardson Jeannette Richardson 6 months ago (edited) I have been a natural faster of sorts - often not eating from 6pm to mid-day the following day and often just one meal, occaisonally a light lunch. Reply Qwant & Swisscows Search-Engines Qwant & Swisscows Search-Engines 6 months ago I have found when I fast, I usually get longer deep sleep on the third night. I could be getting 45 minutes on average, but on the third night I've had as long as 1 hour 50 minutes (1:50:00). 2 Reply CitizenPain CitizenPain 6 months ago I've fasted for 24 hours before, but then had a really hard time falling asleep. Reply Cherry B Cherry B 6 months ago Loved this Dr Been! Reply MaNa VeSt nAtioN MaNa VeSt nAtioN 6 months ago You could have also included the subject of free radicals in regard to fasting. Reply randall hesse randall hesse 6 months ago (edited) Intermittent fasting, to renew and refresh the mitochondria, (I hear). Their are two supplements I've found that are supposed to renew and refresh the mitochondria, methylene blue was one. I forgot the other, berberine maybe. Or maybe D-Ribose. ALA (alpha lipoic acid) as well. 2 Reply Ies Korpershoek Ies Korpershoek 6 months ago I'm on a 20 - 4 schedule, which works fine for me. 2 meals in the 4-hour eating window. First at 13:00 second at 17:00 6 Reply 1 reply Lynn Williams Lynn Williams 2 months ago N of one comment 80 years and I Fast 72 hrs. My glucometer begins glucose drop and ketone rise at 35 hrs in. Evidently Dr Bosworth finds this common too . Great to know about night Autophagy. I am in great health no prescription still run on weekdays inside a gym where I sub ( retired biology teacher). I also do light weight upper body. Never had acetone phenomena but registering two above ketones common on feeding days and upto 5 on Fasting. Reply Timothy Burchett Timothy Burchett 6 months ago GREAT ANGLE!!! GREAT WORK DR. B. Reply Half Baked Alpaca Half Baked Alpaca 6 months ago I drink long black coffee to kick start autophagy during my fast! 2 Reply Mike Brunton Mike Brunton 6 months ago Thank you. I eat during an 8 hour window and I am going to shrink that down by a few hours now. Reply Uncle Vaxx Uncle Vaxx 6 months ago So for neuronal autophagy...OMAD, stop eating at 3 00 go to bed at 11:00 may be the optimal schedule. 2 Reply Bob Thrasher Bob Thrasher 6 months ago Male and female ketosis begins at different times. Female is about 2 days while male is 3 days. 4 Reply 2 replies Thanh Tran Thanh Tran 4 months ago How much spermidine or resveratrol is needed to induce autophagy? Reply Bob Thrasher Bob Thrasher 6 months ago (edited) Also check into Jason Fung on this topic. He has done a good job of pulling together a lot of research on this topic but also making it practical. 15 Reply 4 replies Anna Hellmer Anna Hellmer 3 months ago Is autophagy by fasting also reducing auto-antibodies and microclots, or just crap inside the cells? Reply Diane Dunn Cordle Diane Dunn Cordle 6 months ago Thank you Dr. Been. Reply Rentner Rentner 6 months ago Hm, I have been doing IF for three years now. 7/17. Unfortunately it has not resolved any of my issues. The only side effect is that I can keep my weight easier. 1 Reply himanshu himanshu 6 months ago What about suppliments and autophagy? 1 Reply Mr Propre Mr Propre 6 months ago Loving the drawings, all the support from Luxembourg ✌️ 1 Reply Michele Upchurch Michele Upchurch 6 months ago Thank you!💖 Reply teardropfloyd teardropfloyd 6 months ago Fantastic. Thanks Doctor Been Reply Bhagwanlal Dangi Bhagwanlal Dangi 6 months ago Thanks dr been. Nice article. Reply Real Miami Underground Sessions Real Miami Underground Sessions 6 months ago It’s interesting that animals do this all the time when they are sick but we don’t consider it 2 Reply 1 reply Daniel Kříž Daniel Kříž 6 months ago Amazing. Thank you 🙂 Reply Brian Pancotto Brian Pancotto 6 months ago if you are mentioning this because of covid 19, the gut biome acid doesnt break down the spike protein so this method would 99% surely not work either. 1 Reply 1 reply Jeannette Richardson Jeannette Richardson 6 months ago I think this is why our Asian brothers and sisters who fast regularly look so much younger than westerners. 1 Reply Sonic Shroom Sonic Shroom 4 months ago Does drinking milk with coffee and sugar count as eating? Reply C0nstellati0ns C0nstellati0ns 6 months ago I dont think we recycle every protein in our body every 3 months, that doesn't sound right. It's almost true for red blood cells, but not at all true for hair cells for instance. And that would probably invalidate every stable isotope analysis of collagen. 1 Reply robbie31580 robbie31580 6 months ago (edited) Diabetics should absolutely adopt fasting. Fasting will help to fix the insulin sensitivity problems that the person is having. I have a cardiologist friend who has diabetic patients that he has convinced to start fasting and their diabetes was cured. 5 Reply 2 replies CaLDwELLGoD CaLDwELLGoD 6 months ago This is why 21 day water fasting can heal the body like no other. People dont know this and so many people getting sick! Reply Denise Miller Denise Miller 6 months ago Unclear...when in the terms of the fast should one sleep? If one stops eating at 7PM and goes to bed and gets up at 7AM is that ok? 1 Reply 2 replies Doc Jan Doc Jan 6 months ago When do you then take all your vitamins when your fasting so long cuz it needs to be taken with food??? 5 Reply Corny Corny 6 months ago People have been fasting for health and spiritual benefits from time immemorial, it's nothing new. it's often tied to religious practices, most of which are vanishing as the world becomes increasingly materialistic and atheistic. Most religions contain moral and physical practices that improve well being. 5 Reply 1 reply Nickysticks McFlannigan Nickysticks McFlannigan 6 months ago Dr Been is showing some weakness in his knowledge here. Autophagy from fasting has been studied for a long time and there are folks who practically base their careers on it. Autophagy in animals, especially animals with much faster metabolic cycles than humans (consider how many heartbeats a mouse/rat has). It may be quite a bit longer in humans to trigger autophagy. You might not even be in ketosis within 48 hours of fasting. By all means, if you're interested in this stuff for your health, go looking for more information and use this as a starting point, but don't just dive into 48 hour fasts (most people will struggle with that anyway) and don't necessarily assume you'll get the benefits discussed in animal models/studies within the same fasting window. 1 Reply Drbeen Medical Lectures · 2 replies hAckAble Me hAckAble Me 4 months ago Well, one thing's for sure these days.... Many people have a lot of "junk" jabbed into their cells. Reply Widya Walesa Widya Walesa 6 months ago That's why we are told to fast, just like those before us 3 Reply GM GM 6 months ago Are there any supplements to repair or replace damaged mitochondria? 2 Reply 14 replies Sheri Ciancaglini Sheri Ciancaglini 6 months ago How can one take supplements on a fast? Like vitamin D 1 Reply Fillmore Hillmore Fillmore Hillmore 6 months ago Going without is good. You will own nothing and eat nothing and be happy. 19 Reply 4 replies wattsobx wattsobx 6 months ago (edited) Look into dry fasting 1 Reply Jonnes __ Jonnes __ 6 months ago Looking this video I get hungry. 🤔.... waiting for the next meal. What is the influence of coffee ??? 2 Reply JKM jemmadesigns JKM jemmadesigns 6 months ago Dr Marshal..The confusing thing to modern Americans is that in English the suffix 'co' implies a kind of equality...So the way it is said is not correct for the full meaning you describe here. Abreviating when it comes to the Mother of God is probably a mistake in the first place.( and just a note two posts seem to have come together I see comments to dr Kool Bean under this too!) Reply Lynn Williams Lynn Williams 2 months ago Hard to do rodents bc difficult to raise ketones. Me, n of one, 36 hr in great fall of glucose raise of ketones at that point. Reply Sheri Ciancaglini Sheri Ciancaglini 6 months ago (edited) I have done 20 hr fasts. I may try 24 3 Reply irina irina irina irina 6 months ago Thank you 2 Reply Glenn Sundbakken Glenn Sundbakken 6 months ago NOK 20.00 Takk! 1 Reply dahkneelah dahkneelah 6 months ago Thanks Reply DE Graham DE Graham 6 months ago (edited) FBI. Holland. Smith. Calling me fat. Perfect example of harassment using a theme. Seemingly innocuous, but the pattern is apparent to the victim. Reply James Hyde James Hyde 2 months ago Do cancer cells feed on ketones? Previous studies indicate that unlike healthy tissues, cancer cells are unable to effectively use ketone bodies for energy. Furthermore, ketones inhibit the proliferation and viability of cultured tumor cells. I am a avid follower of your presentations and thank you for your work. However I felt very strongly that your comment regarding my statement above needs your investigation. However I realize your agreement with the statement could be very harmful to you relative to the big Pharma regime see Dr Burzynski Cancer Clinic. Bottom line cancer cells need glucose but cannot survive on ketones. Fasting is a successful therapy. Thank you again for your work Reply Raj Sakaria Raj Sakaria 6 months ago This guy is to Medical Research as Jordan Peterson is to Psychology. 8 Reply Reubz รูเบน Reubz รูเบน 8 months ago I fast from midnight to 8am everyday, consistently. I want to reach autophagy Reply DAVID FRANKLIN DAVID FRANKLIN 1 year ago Getting rid of processed foods makes this process more manageable. 71 Reply Jessica Johnson Jessica Johnson 1 year ago Thank you for explaining this! I'm hoping I have autophagy when I do my 48 hr fasts every four days and I'm on a LCHF OMAD for weight loss the other days. I'm wondering if my heavy cream in my coffee is enough protein to disrupt autophagy? I actually look forward to my longer fasts. I feel so well!! Thank you Dr Fung for all you do! 10 Reply 10 replies David Yan David Yan 8 months ago Hi Jason, Can Autophagy turn EGFR mutation from positive to negative? Thanks Reply Dr. Rup Kumar Rai Dr. Rup Kumar Rai 1 year ago Great! it is proven system in east society before too. Reply Naeem Khan Naeem Khan 4 years ago Nobel prize wasted, I am a Muslim and our Prophet Muhammad Peace be Upon Him, told us this 1400 hundreds years ago. That's why we fast 30 days a year. 4 Reply Yoshinori Ohsumi Yoshinori Ohsumi 大隅 良典 Article Talk Read Edit View history Tools From Wikipedia, the free encyclopedia Yoshinori Ohsumi Nobel Laureates 7428 (30679389523) (cropped).jpg Ohsumi in 2016 Born February 9, 1945 (age 78) Fukuoka, Japan Alma mater University of Tokyo (B.Sc) (D.Sc) Rockefeller University (Post-Doc) Known for Autophagy Awards Kyoto Prize (2012) Gairdner Foundation International Award (2015) Nobel Prize in Physiology or Medicine (2016) Breakthrough Prize in Life Sciences (2017) Scientific career Fields Cell biologist Institutions Tokyo Institute of Technology Website www.ohsumilab.aro.iri.titech.ac.jp/english.html Yoshinori Ohsumi (大隅 良典, Ōsumi Yoshinori, born February 9, 1945) is a Japanese cell biologist specializing in autophagy, the process that cells use to destroy and recycle cellular components. Ohsumi is a professor at Tokyo Institute of Technology's Institute of Innovative Research.[1] He received the Kyoto Prize for Basic Sciences in 2012,[2] the 2016 Nobel Prize in Physiology or Medicine, and the 2017 Breakthrough Prize in Life Sciences[3] for his discoveries of mechanisms for autophagy.[4] Biography Ohsumi addressed at Gairdner Foundation International Award Ceremony (at the Royal Ontario Museum in October 2015) with John Dirks, Kenjirō Monji and D. Lorne Tyrrell Ohsumi was born on February 9, 1945, in Fukuoka. He received a B.Sci. in 1967 and a D.Sci. in 1974, both from the University of Tokyo. In 1974–77 he was a postdoctoral fellow at the Rockefeller University in New York City.[1] He returned to the University of Tokyo in 1977 as a research associate; he was appointed Lecturer there in 1986, and promoted to Associate Professor in 1988. In 1996, he moved to the National Institute for Basic Biology, Japan in Okazaki City, where he was appointed as a professor. From 2004 to 2009, he was also professor at the Graduate University for Advanced Studies in Hayama. In 2009, he transitioned to a three-way appointment as an emeritus professor at the National Institute for Basic Biology and at the Graduate University for Advanced Studies, and a professorship at the Advanced Research Organization, Integrated Research Institute, Tokyo Institute of Technology (Tokyo Tech). After his retirement in 2014, he continued to serve as Professor at Institute of Innovative Research, Tokyo Institute of Technology. Currently, he is head of the Cell Biology Research Unit, Institute of Innovative Research, Tokyo Institute of Technology.[5] Christian de Duve coined the term autophagy in 1963 whereas Ohsumi began his work in 1988. Prior to that time, less than 20 papers per year were published on this subject.[6] During the 1990s, Ohsumi's group described the morphology of autophagy in yeast, and performed mutational screening on yeast cells that identified essential genes for cells to be capable of autophagy.[7][8] In 2016, he was awarded the Nobel Prize in Physiology or Medicine "for his discoveries of mechanisms for autophagy".[9][10] He is the 25th Japanese person to be awarded a Nobel Prize.[11] Ohsumi's spouse Mariko, a Professor of Teikyo University of Science, collaborated on his research.[12] She is a co-author of many academic papers with him.[13] Recognition Ohsumi in his Tokyo Tech lab Source:[5] 2005 – Fujihara Award, Fujihara Foundation of Science 2006 – Japan Academy Prize, Japan Academy 2007 – Science Award, Botanical Society of Japan [ja] 2008 – Asahi Prize, Asahi Shimbun 2012 – Kyoto Prize in Basic Sciences[14] 2013 – Thomson Reuters Citation Laureate 2015 – Gairdner Foundation International Award 2015 – International Prize for Biology 2015 – Keio Medical Science Prize 2015 – Person of Cultural Merit 2015 – Rosenstiel Award 2016 – Wiley Prize in Biomedical Sciences 2016 – Dr. Paul Janssen Award for Biomedical Research 2016 – Nobel Prize in Physiology or Medicine[15] 2017 – Breakthrough Prize in Life Sciences[16] Selected publications His original findings about autophagy in yeast cells:[17] Takeshige K; Baba M; Tsuboi S; Noda T; Ohsumi Y (October 1992). "Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction". Journal of Cell Biology. 119 (2): 301–11. doi:10.1083/JCB.119.2.301. ISSN 0021-9525. JSTOR 1615399. PMC 2289660. PMID 1400575. Wikidata Q29614187. Follow up with more research on yeast:[17] Baba M; Takeshige K; Baba N; Ohsumi Y (March 1, 1994). "Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization". Journal of Cell Biology. 124 (6): 903–913. doi:10.1083/JCB.124.6.903. ISSN 0021-9525. JSTOR 1616094. PMC 2119983. PMID 8132712. Wikidata Q34337565. Others M Tsukada; Y Ohsumi (October 25, 1993). "Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae". FEBS Letters. 333 (1–2): 169–74. doi:10.1016/0014-5793(93)80398-E. ISSN 0014-5793. PMID 8224160. S2CID 46017791. Wikidata Q27935838. N Mizushima; T Noda; T Yoshimori; et al. (September 24, 1998). "A protein conjugation system essential for autophagy". Nature. 395 (6700): 395–8. Bibcode:1998Natur.395..395M. doi:10.1038/26506. ISSN 1476-4687. PMID 9759731. S2CID 204997310. Wikidata Q27940154. Y Kabeya; N Mizushima; T Ueno; et al. (November 1, 2000). "LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing". The EMBO Journal. 19 (21): 5720–8. doi:10.1093/EMBOJ/19.21.5720. ISSN 0261-4189. PMC 305793. PMID 11060023. Wikidata Q24597817. Y Ichimura; T Kirisako; T Takao; et al. (November 23, 2000). "A ubiquitin-like system mediates protein lipidation". Nature. 408 (6811): 488–92. Bibcode:2000Natur.408..488I. doi:10.1038/35044114. ISSN 1476-4687. PMID 11100732. S2CID 4428142. Wikidata Q27934137. Y Ohsumi (March 2001). "Molecular dissection of autophagy: two ubiquitin-like systems". Nature Reviews Molecular Cell Biology. 2 (3): 211–6. doi:10.1038/35056522. ISSN 1471-0072. PMID 11265251. S2CID 38001477. Wikidata Q28206420. Kuma A; Hatano M; Matsui M; et al. (December 23, 2004). "The role of autophagy during the early neonatal starvation period". Nature. 432 (7020): 1032–6. Bibcode:2004Natur.432.1032K. doi:10.1038/NATURE03029. ISSN 1476-4687. PMID 15525940. S2CID 4424974. Wikidata Q29547489. Sho W Suzuki; Jun Onodera; Yoshinori Ohsumi (2011). "Starvation induced cell death in autophagy-defective yeast mutants is caused by mitochondria dysfunction". PLOS One. 6 (2): e17412. Bibcode:2011PLoSO...617412S. doi:10.1371/JOURNAL.PONE.0017412. ISSN 1932-6203. PMC 3045454. PMID 21364763. Wikidata Q27077073. Takao Hanada; Nobuo N Noda; Yoshinori Satomi; Yoshinobu Ichimura; Yuko Fujioka; Toshifumi Takao; Fuyuhiko Inagaki; Yoshinori Ohsumi (December 28, 2007). "The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy". Journal of Biological Chemistry. 282 (52): 37298–302. doi:10.1074/JBC.C700195200. ISSN 0021-9258. PMID 17986448. Wikidata Q27933717. Michitaro Shibata; Kazusato Oikawa; Kohki Yoshimoto; et al. (December 24, 2013). "Highly oxidized peroxisomes are selectively degraded via autophagy in Arabidopsis". The Plant Cell. 25 (12): 4967–4983. doi:10.1105/TPC.113.116947. ISSN 1040-4651. JSTOR 43190612. PMC 3903999. PMID 24368788. Wikidata Q34394370. Hayashi Yamamoto; Takayuki Shima; Masaya Yamaguchi; et al. (October 6, 2015). "The Thermotolerant Yeast Kluyveromyces marxianus Is a Useful Organism for Structural and Biochemical Studies of Autophagy". Journal of Biological Chemistry. 290 (49): 29506–29518. doi:10.1074/JBC.M115.684233. ISSN 0021-9258. PMC 4705951. PMID 26442587. Wikidata Q34497110. Hayashi Yamamoto; Yuko Fujioka; Sho W Suzuki; et al. (July 11, 2016). "The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes". Developmental Cell. 38 (1): 86–99. doi:10.1016/J.DEVCEL.2016.06.015. ISSN 1534-5807. PMID 27404361. Wikidata Q27718642. See also List of Japanese Nobel laureates List of Nobel laureates affiliated with the University of Tokyo References Yoshinori Ohsumi's ORCID 0000-0003-2384-2166 Biemiller, Lawrence (November 10, 2012). "Kyoto Prize Is Awarded to 3 Scholars". The Chronicle of Higher Education Blogs: The Ticker. Retrieved October 4, 2016. "Laureates—Breakthrough Prize". Breakthrough Prize. Retrieved December 5, 2016. "The Nobel Prize in Physiology or Medicine 2016". The Nobel Foundation. October 3, 2016. Retrieved October 3, 2016. "Yoshinori Ohsumi Biography". Institute of Innovative Research, Tokyo Institute of Technology. Retrieved October 10, 2016. "Yoshinori Ohsumi: What is autophagy? A dynamic cellular recycling process". Molecular Frontiers Symposium at the Tokyo Institute of Technology, Japan. October 2017. Retrieved January 15, 2018. Science Staff (October 3, 2016). "Nobel honors discoveries on how cells eat themselves". Science. doi:10.1126/SCIENCE.AAH7373. ISSN 0036-8075. Wikidata Q57407776. Klionsky DJ (November 2007). "Autophagy: from phenomenology to molecular understanding in less than a decade". Nature Reviews Molecular Cell Biology. 8 (11): 931–7. doi:10.1038/NRM2245. ISSN 1471-0072. PMID 17712358. S2CID 7376303. Wikidata Q29614174. "Yoshinori Ohsumi – Nobel Lecture: Autophagy – an Intracellular Recycling System". Nobel Prize. December 7, 2016. Retrieved January 15, 2018. Kolata, Gina; Chan, Sewell (October 3, 2016). "Yoshinori Ohsumi of Japan Wins Nobel Prize for Study of 'Self-Eating' Cells". The New York Times. Retrieved October 10, 2016. Wanklyn, Alastair (October 3, 2016). "Japanese microbiologist Yoshinori Ohsumi wins Nobel in medicine for autophagy research". The Japan Times. Retrieved October 8, 2016. "大隅萬里子教授の共同研究がノーベル医学・生理学賞として選定されました" [A joint research of Professor Mariko Ohsumi won Nobel Prize in Physiology or Medicine]. Teikyo University of Science. October 5, 2016. "Google Scholar". Scholar.google.com. "Yoshinori Ohsumi". Kyoto Prize. Retrieved October 3, 2016. "Yoshinori Ohsumi wins Nobel prize in medicine for work on autophagy". The Guardian. Retrieved October 3, 2016. "Breakthrough Prize – Life Sciences : Breakthrough Prize Laureates – Yoshinori Ohsumi". Breakthroughprize.org. Retrieved October 15, 2018. "Nobel Prize Laureate Yoshinori Ohsumi's Work". Jstor Daily. October 3, 2016. External links Yoshinori Ohsumi on Nobelprize.org Edit this at Wikidata inclkuding the Nobel Lecture December 7, 2016 Molecular Mechanisms of Autophagy in Yeast vte Laureates of the Nobel Prize in Physiology or Medicine vte 2016 Nobel Prize laureates vte Japanese Nobel laureates vte Breakthrough Prize laureates Scholia has an author profile for Yoshinori Ohsumi. Authority control Edit this at Wikidata Yoshinori Ohsumi Nobel Laureates 7428 (30679389523) (cropped).jpg Ohsumi in 2016 Born February 9, 1945 (age 78) Fukuoka, Japan Alma mater University of Tokyo (B.Sc) (D.Sc) Rockefeller University (Post-Doc) Known for Autophagy Awards Kyoto Prize (2012) Gairdner Foundation International Award (2015) Nobel Prize in Physiology or Medicine (2016) Breakthrough Prize in Life Sciences (2017) Scientific career Fields Cell biologist Institutions Tokyo Institute of Technology Website www.ohsumilab.aro.iri.titech.ac.jp/english.html Yoshinori Ohsumi (大隅 良典, Ōsumi Yoshinori, born February 9, 1945) is a Japanese cell biologist specializing in autophagy, the process that cells use to destroy and recycle cellular components. Ohsumi is a professor at Tokyo Institute of Technology's Institute of Innovative Research.[1] He received the Kyoto Prize for Basic Sciences in 2012,[2] the 2016 Nobel Prize in Physiology or Medicine, and the 2017 Breakthrough Prize in Life Sciences[3] for his discoveries of mechanisms for autophagy.[4] Biography Ohsumi addressed at Gairdner Foundation International Award Ceremony (at the Royal Ontario Museum in October 2015) with John Dirks, Kenjirō Monji and D. Lorne Tyrrell Ohsumi was born on February 9, 1945, in Fukuoka. He received a B.Sci. in 1967 and a D.Sci. in 1974, both from the University of Tokyo. In 1974–77 he was a postdoctoral fellow at the Rockefeller University in New York City.[1] He returned to the University of Tokyo in 1977 as a research associate; he was appointed Lecturer there in 1986, and promoted to Associate Professor in 1988. In 1996, he moved to the National Institute for Basic Biology, Japan in Okazaki City, where he was appointed as a professor. From 2004 to 2009, he was also professor at the Graduate University for Advanced Studies in Hayama. In 2009, he transitioned to a three-way appointment as an emeritus professor at the National Institute for Basic Biology and at the Graduate University for Advanced Studies, and a professorship at the Advanced Research Organization, Integrated Research Institute, Tokyo Institute of Technology (Tokyo Tech). After his retirement in 2014, he continued to serve as Professor at Institute of Innovative Research, Tokyo Institute of Technology. Currently, he is head of the Cell Biology Research Unit, Institute of Innovative Research, Tokyo Institute of Technology.[5] Christian de Duve coined the term autophagy in 1963 whereas Ohsumi began his work in 1988. Prior to that time, less than 20 papers per year were published on this subject.[6] During the 1990s, Ohsumi's group described the morphology of autophagy in yeast, and performed mutational screening on yeast cells that identified essential genes for cells to be capable of autophagy.[7][8] In 2016, he was awarded the Nobel Prize in Physiology or Medicine "for his discoveries of mechanisms for autophagy".[9][10] He is the 25th Japanese person to be awarded a Nobel Prize.[11] Ohsumi's spouse Mariko, a Professor of Teikyo University of Science, collaborated on his research.[12] She is a co-author of many academic papers with him.[13] Recognition Ohsumi in his Tokyo Tech lab Source:[5] 2005 – Fujihara Award, Fujihara Foundation of Science 2006 – Japan Academy Prize, Japan Academy 2007 – Science Award, Botanical Society of Japan [ja] 2008 – Asahi Prize, Asahi Shimbun 2012 – Kyoto Prize in Basic Sciences[14] 2013 – Thomson Reuters Citation Laureate 2015 – Gairdner Foundation International Award 2015 – International Prize for Biology 2015 – Keio Medical Science Prize 2015 – Person of Cultural Merit 2015 – Rosenstiel Award 2016 – Wiley Prize in Biomedical Sciences 2016 – Dr. Paul Janssen Award for Biomedical Research 2016 – Nobel Prize in Physiology or Medicine[15] 2017 – Breakthrough Prize in Life Sciences[16] Selected publications His original findings about autophagy in yeast cells:[17] Takeshige K; Baba M; Tsuboi S; Noda T; Ohsumi Y (October 1992). "Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction". Journal of Cell Biology. 119 (2): 301–11. doi:10.1083/JCB.119.2.301. ISSN 0021-9525. JSTOR 1615399. PMC 2289660. PMID 1400575. Wikidata Q29614187. Follow up with more research on yeast:[17] Baba M; Takeshige K; Baba N; Ohsumi Y (March 1, 1994). "Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization". Journal of Cell Biology. 124 (6): 903–913. doi:10.1083/JCB.124.6.903. ISSN 0021-9525. JSTOR 1616094. PMC 2119983. PMID 8132712. Wikidata Q34337565. Others M Tsukada; Y Ohsumi (October 25, 1993). "Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae". FEBS Letters. 333 (1–2): 169–74. doi:10.1016/0014-5793(93)80398-E. ISSN 0014-5793. PMID 8224160. S2CID 46017791. Wikidata Q27935838. N Mizushima; T Noda; T Yoshimori; et al. (September 24, 1998). "A protein conjugation system essential for autophagy". Nature. 395 (6700): 395–8. Bibcode:1998Natur.395..395M. doi:10.1038/26506. ISSN 1476-4687. PMID 9759731. S2CID 204997310. Wikidata Q27940154. Y Kabeya; N Mizushima; T Ueno; et al. (November 1, 2000). "LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing". The EMBO Journal. 19 (21): 5720–8. doi:10.1093/EMBOJ/19.21.5720. ISSN 0261-4189. PMC 305793. PMID 11060023. Wikidata Q24597817. Y Ichimura; T Kirisako; T Takao; et al. (November 23, 2000). "A ubiquitin-like system mediates protein lipidation". Nature. 408 (6811): 488–92. Bibcode:2000Natur.408..488I. doi:10.1038/35044114. ISSN 1476-4687. PMID 11100732. S2CID 4428142. Wikidata Q27934137. Y Ohsumi (March 2001). "Molecular dissection of autophagy: two ubiquitin-like systems". Nature Reviews Molecular Cell Biology. 2 (3): 211–6. doi:10.1038/35056522. ISSN 1471-0072. PMID 11265251. S2CID 38001477. Wikidata Q28206420. Kuma A; Hatano M; Matsui M; et al. (December 23, 2004). "The role of autophagy during the early neonatal starvation period". Nature. 432 (7020): 1032–6. Bibcode:2004Natur.432.1032K. doi:10.1038/NATURE03029. ISSN 1476-4687. PMID 15525940. S2CID 4424974. Wikidata Q29547489. Sho W Suzuki; Jun Onodera; Yoshinori Ohsumi (2011). "Starvation induced cell death in autophagy-defective yeast mutants is caused by mitochondria dysfunction". PLOS One. 6 (2): e17412. Bibcode:2011PLoSO...617412S. doi:10.1371/JOURNAL.PONE.0017412. ISSN 1932-6203. PMC 3045454. PMID 21364763. Wikidata Q27077073. Takao Hanada; Nobuo N Noda; Yoshinori Satomi; Yoshinobu Ichimura; Yuko Fujioka; Toshifumi Takao; Fuyuhiko Inagaki; Yoshinori Ohsumi (December 28, 2007). "The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy". Journal of Biological Chemistry. 282 (52): 37298–302. doi:10.1074/JBC.C700195200. ISSN 0021-9258. PMID 17986448. Wikidata Q27933717. Michitaro Shibata; Kazusato Oikawa; Kohki Yoshimoto; et al. (December 24, 2013). "Highly oxidized peroxisomes are selectively degraded via autophagy in Arabidopsis". The Plant Cell. 25 (12): 4967–4983. doi:10.1105/TPC.113.116947. ISSN 1040-4651. JSTOR 43190612. PMC 3903999. PMID 24368788. Wikidata Q34394370. Hayashi Yamamoto; Takayuki Shima; Masaya Yamaguchi; et al. (October 6, 2015). "The Thermotolerant Yeast Kluyveromyces marxianus Is a Useful Organism for Structural and Biochemical Studies of Autophagy". Journal of Biological Chemistry. 290 (49): 29506–29518. doi:10.1074/JBC.M115.684233. ISSN 0021-9258. PMC 4705951. PMID 26442587. Wikidata Q34497110. Hayashi Yamamoto; Yuko Fujioka; Sho W Suzuki; et al. (July 11, 2016). "The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes". Developmental Cell. 38 (1): 86–99. doi:10.1016/J.DEVCEL.2016.06.015. ISSN 1534-5807. PMID 27404361. Wikidata Q27718642. See also List of Japanese Nobel laureates List of Nobel laureates affiliated with the University of Tokyo References Yoshinori Ohsumi's ORCID 0000-0003-2384-2166 Biemiller, Lawrence (November 10, 2012). "Kyoto Prize Is Awarded to 3 Scholars". The Chronicle of Higher Education Blogs: The Ticker. Retrieved October 4, 2016. "Laureates—Breakthrough Prize". Breakthrough Prize. Retrieved December 5, 2016. "The Nobel Prize in Physiology or Medicine 2016". The Nobel Foundation. October 3, 2016. Retrieved October 3, 2016. "Yoshinori Ohsumi Biography". Institute of Innovative Research, Tokyo Institute of Technology. Retrieved October 10, 2016. "Yoshinori Ohsumi: What is autophagy? A dynamic cellular recycling process". Molecular Frontiers Symposium at the Tokyo Institute of Technology, Japan. October 2017. Retrieved January 15, 2018. Science Staff (October 3, 2016). "Nobel honors discoveries on how cells eat themselves". Science. doi:10.1126/SCIENCE.AAH7373. ISSN 0036-8075. Wikidata Q57407776. Klionsky DJ (November 2007). "Autophagy: from phenomenology to molecular understanding in less than a decade". Nature Reviews Molecular Cell Biology. 8 (11): 931–7. doi:10.1038/NRM2245. ISSN 1471-0072. PMID 17712358. S2CID 7376303. Wikidata Q29614174. "Yoshinori Ohsumi – Nobel Lecture: Autophagy – an Intracellular Recycling System". Nobel Prize. December 7, 2016. Retrieved January 15, 2018. Kolata, Gina; Chan, Sewell (October 3, 2016). "Yoshinori Ohsumi of Japan Wins Nobel Prize for Study of 'Self-Eating' Cells". The New York Times. Retrieved October 10, 2016. Wanklyn, Alastair (October 3, 2016). "Japanese microbiologist Yoshinori Ohsumi wins Nobel in medicine for autophagy research". The Japan Times. Retrieved October 8, 2016. "大隅萬里子教授の共同研究がノーベル医学・生理学賞として選定されました" [A joint research of Professor Mariko Ohsumi won Nobel Prize in Physiology or Medicine]. Teikyo University of Science. October 5, 2016. "Google Scholar". Scholar.google.com. "Yoshinori Ohsumi". Kyoto Prize. Retrieved October 3, 2016. "Yoshinori Ohsumi wins Nobel prize in medicine for work on autophagy". The Guardian. Retrieved October 3, 2016. "Breakthrough Prize – Life Sciences : Breakthrough Prize Laureates – Yoshinori Ohsumi". Breakthroughprize.org. Retrieved October 15, 2018. "Nobel Prize Laureate Yoshinori Ohsumi's Work". Jstor Daily. October 3, 2016. External links Yoshinori Ohsumi on Nobelprize.org Edit this at Wikidata inclkuding the Nobel Lecture December 7, 2016 Molecular Mechanisms of Autophagy in Yeast vte Laureates of the Nobel Prize in Physiology or Medicine vte 2016 Nobel Prize laureates vte Japanese Nobel laureates vte Breakthrough Prize laureates Scholia has an author profile for Yoshinori Ohsumi. Authority control Edit this at Wikidata 3 years ago A one day fasting is known as