mTOR & Rapamycin | Lifespan with Dr. David Sinclair

mTOR & Rapamycin | Lifespan with Dr. David Sinclair My NMN Experiment 21.5K subscribers In this clip, Dr. David Sinclair and co-host Matthew LaPlante discuss mTOR (Mammalian Target of Rapamycin) and Rapamycin. FAIR-USE COPYRIGHT DISCLAIMER Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, commenting, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational, or personal use tips the balance in favor of fair use. Links: Rapamycin extends lifespan in mice - https://go.nature.com/3F0yud3 Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsincla... Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclai... Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante DISCLAIMER: The Video Content has been made available for informational and educational purposes only. The video creator does not make any representation or warranties with respect to the accuracy, applicability, fitness, or completeness of the Video Content. The Video Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. The video creator hereby disclaims any and all liability to any party for any direct, indirect, implied, punitive, special, incidental or other consequential damages arising directly or indirectly from any use of the Video Content, which is provided as is, and without warranties. Discovered by David Sinclair PhD, NMN or Nicotinamide Mononucleotide is the pre-cursor to NAD+ (Nicotinamide Adenine Dinucleotide), NAD is found in nearly all our living cells. NAD is essential for sustaining life. Dr. David Sinclair (a professor at Harvard Medical School) once said if we suddenly didn’t have NAD we would be dead within eight seconds.’ Unfortunately, as we age our NAD levels drastically decline, clinical studies have shown that by age of 50 a typical person could have half the NAD+ they did in their youth and by the age of 80 our NAD+ (Nicotinamide Adenine Dinucleotide) levels drop to around 1% to 10% of those enjoyed in our youth. NAD is biologically unstable, which makes it unsuitable for oral supplementation. Fortunately, it is easy to restore our cellular NAD levels using NMN (Nicotinamide Mononucleotide) or NR (Nicotinamide Riboside), which convert to NAD when it is in the cell. These NAD boosting supplements can be purchased from reputable companies such as Do Not Age, Renue by Science and Pro-health Longevity, however there are many unscrupulous companies selling fake NMN, so buyer beware. Dr. David Sinclair confirms that a fascinating aspect of NAD+ is its dual role in protecting against factors that age us. This includes mitigating chemical stress, inflammation, DNA damage and failing mitochondria; all conditions associated with aging. In other words, while a decline in NAD+ levels may negatively influence lifespan and Healthspan (health-span), so restoring NAD+ is increasingly being viewed as a scientific way to promote longevity and a way to combat the diseases of aging too. A rigorous scientific review of NAD+ reveals that its longevity benefits arise from eight different, but interrelated, functions. In 2013 a scientific study; 2-year old mice were tested for muscle wastage, insulin resistance and inflammation, all are, on humans used as indicators of the aging process, they were then given NMN (Nicotinamide Mononucleotide) for 1 week. In all cases, after only 1 week the 2-year old mice were reflecting the expected findings of 6-month old mice in the areas of muscle wastage, insulin resistance and inflammation. In human terms that would be comparable to a 75-year old having the results you would expect from a 25-year old. In a later methodical study, in 2018, again on mice, Dr. David Sinclair’s team at the Harvard Medical School found that the aging of blood vessels had been reversed. #mTOR #Rapamycin #Healthspan 39 Comments rongmaw lin Add a comment... Ron M Ron M 4 weeks ago Thank you. 👍🏻 1 My NMN Experiment bob lolo bob lolo 1 month ago Would apigenin work the same? 2 My NMN Experiment Huw and Angela’s vlogs🍪❤️ Huw and Angela’s vlogs🍪❤️ 1 month ago ❤️❤️❤️ 1 My NMN Experiment Tony Ruggia - The Road To 120 Tony Ruggia - The Road To 120 1 month ago So, why can't I eat a high protein diet, and intermittent fast from 5:00PM to 9:00AM. And at the same time, supplement with NMN, resveratrol, apigenin, etc.? There are no studies showing the effects of this plan. Dr. Sinclair is referring to the average person that does not supplement ith longevity supplements. 1 My NMN Experiment Igal Marcelo Zimmt Igal Marcelo Zimmt 1 month ago fisetin also targets mTOR 1 My NMN Experiment Omar Arreola Omar Arreola 1 month ago Interesting need new studies out 1 My NMN Experiment Rose van der Reijden Rose van der Reijden 1 month ago It's strange how my comments disappear when I come back to this on my phone. I guess anything less-than-flattering of Sinclair is not allowed here. 1 The Connection Of 3 Longevity Pathways | Dr David Sinclair Interview Clips 1,311 viewsDec 25, 2021 97 DISLIKE SHARE DOWNLOAD SAVE Reverse Aging Revolution 17.9K subscribers According to Dr David Sinclair, 3 main longevity pathways AMPK, mTOR and sirtuins are communicating with each other. It's potential to have a pill which can activate all 3 pathways in a beneficial way. David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming. Dr David Sinclair has suggested that aging is a disease—and that we may soon have the tools to put it into remission—and he has called for greater international attention to the social, economic and political and benefits of a world in which billions of people can live much longer and much healthier lives. Dr David Sinclair is the co-founder of several biotechnology companies (Life Biosciences, Sirtris, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging. He is an inventor on 35 patents and has received more than 35 awards and honors. In 2014, he was on Time Magazine’s list of the “100 Most Influential People in the World,” and listed as Time's Top 50 in healthcare in 2018. ___________________________________________ DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes. #DavidSinclair #sirtuin #mTOR #AMPK #metformin #ALA #AlphaLipoicAcid #ReverseAging #Sirtuin #Nicotinamide #Epigenetic #OleicAcid #NMN #NAD #Sirtuins #Fasting #Exercise #NADIV #Longevity #RestoreYouth #Reprogramming #DrDavidSinclair #DrSinclairLab #Lifespan #Healthspan #Younger #Resveratrol #antiaging #DrSinclair #NAD #longevity #Epigenome 4 Comments rongmaw lin Add a comment... Reverse Aging Revolution Pinned by Reverse Aging Revolution Reverse Aging Revolution 3 months ago ~~ In case you miss any, Recommended Videos ~~ Calorie Restriction For Longevity https://youtu.be/OERlcan_F9Q The Launch Of Dr David Sinclair’s New Lifespan Podcast https://youtu.be/dprW8ncixIw Universal Regulators of Aging https://youtu.be/OdVVIVhamQg Sirtuin 6, Retrotransposons & Senescent Cells https://youtu.be/MC1VtdyS0T8 5 Mins Healthy Longevity Lesson From Harvard https://youtu.be/dQDjsTFlrhk Well, how old is this sound bite, now?