mTOR And Sirtuins Impact Our Longevity | Dr David Sinclair Interview Clips

HOW mTOR And Sirtuins Impact Our Longevity | Dr David Sinclair Interview Clips 2,934 viewsFeb 27, 2022 Reverse Aging Revolution 17.9K subscribers In this interview clip, Dr David Sinclair reveals how mTOR and sirtuins affect our health and longevity. David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming. Dr David Sinclair has suggested that aging is a disease—and that we may soon have the tools to put it into remission—and he has called for greater international attention to the social, economic and political and benefits of a world in which billions of people can live much longer and much healthier lives. Dr David Sinclair is the co-founder of several biotechnology companies (Life Biosciences, Sirtris, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging. He is an inventor on 35 patents and has received more than 35 awards and honors. In 2014, he was on Time Magazine’s list of the “100 Most Influential People in the World,” and listed as Time's Top 50 in healthcare in 2018. ___________________________________________ DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes. #DavidSinclair #Sirtuin #mTOR #HIIT #Resveratrol #OliveOil #aging #Lifespan #NMN #NR #Spermidine #Fisetin #Quercetin #Metformin #Berberine #ReverseAging #Epigenetic #OleicAcid #NMN #NAD #Sirtuins #Fasting #Longevity #RestoreYouth #Reprogramming #DavidSinclair #DrSinclairLab #Healthspan #Younger #antiaging #DrSinclair #NAD #longevity #Bioscience #Epigenome DAVID SINCLAIR ” Get mTOR Right For Longevity” | Dr David Sinclair Interview Clips 6,215 viewsNov 25, 2021 263 DISLIKE SHARE DOWNLOAD CLIP SAVE Reverse Aging Revolution 17.9K subscribers The scientific discovery is that there are three main longevity pathways or mechanisms in our bodies. The first are sirtuins, a family of proteins that regulate cellular health which respond to the environment. Another one is called AMPK -activating protein kinase, one of the major autophagy regulator. Then, there’s mTOR - mechanistic target of rapamycin, which is activated by amino acids, insulin, and growth factors, and impaired by nutrient or energy deficiency. The activation of any one of these three pillars of longevity will give health benefits that slow down aging. David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming. Dr David Sinclair has suggested that aging is a disease—and that we may soon have the tools to put it into remission—and he has called for greater international attention to the social, economic and political and benefits of a world in which billions of people can live much longer and much healthier lives. Dr David Sinclair is the co-founder of several biotechnology companies (Life Biosciences, Sirtris, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging. He is an inventor on 35 patents and has received more than 35 awards and honors. In 2014, he was on Time Magazine’s list of the “100 Most Influential People in the World,” and listed as Time's Top 50 in healthcare in 2018. ___________________________________________ DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes. #DavidSinclair #mTOR #Longevity #NMN #NAD #CircadianRhythm #OleicAcid #Sirtuins #Fasting #Exercise #ReverseAging #NMN #NADIV #Longevity #Epigenetic #RestoreYouth #Reprogramming #DavidSinclair #DrSinclairLab #Lifespan #Healthspan #Younger #Resveratrol #antiaging #DrSinclair #NAD #Bioscience #Epigenome #LongevityPathways 21 Comments rongmaw lin Add a comment... Reverse Aging Revolution Pinned by Reverse Aging Revolution Reverse Aging Revolution 4 months ago ~~ Recommended Videos ~~ New Aging Reversal Approaches 2021 Update https://youtu.be/9rB89ydZoRo Dr Sinclair & Dr Huberman - NMN, NAD, Sleep & Circadian Rhythm- https://youtu.be/kPS7DYkk9vI 3 Tips to Reverse Your Parents' Age by Decade https://www.youtube.com/watch?v=LknHcw924gg Turning Back the Clock Of Aging Skin https://youtu.be/uehPxgSpQEs WHEN You Eat Is More Important Than WHAT You Eat https://youtu.be/tk4xnPA2q88 5 Paul Paul 4 months ago (edited) Hi David,really enjoy your videos on aging. As you know as we age, particularly in our 70s or 80s we lose muscle mass.Do you think we should try to build up some muscle prior to this to offset later loss?I say this as a slim guy like yourself albeit in my 60s. 1 Sean Dreiling Sean Dreiling 4 months ago I love how going plant-based is the "go-to" for avoiding mTor activation and reducing methionine consumption... yet people don't realize there are still BCAA's and methionine (sometimes in high amounts) in plant-based, high protein foods (especially protein powders like pea protein). Furthermore, there is no metric to gauge, measure or limit one's BCAA consumption (i.e. more than 3g per day of Leucine is the maximum you want consume for longevity purposes, as an example). 2 Jen Holmes Jen Holmes 4 weeks ago Haven’t eaten meat for 20 years in my seventys & super fit & healthy. Ever since I stopped eating animal products my fitness has gone through the roof. 1 AP AP 1 month ago Hi! I really enjoy watching your videos. But there is still lot of confusion about Mtor. I’m on keto and exercise pretty much 5 days a week with muscle training on 2 day and HIIT on other 3 days. I take 1gm NMN and reservertol every morning. I’ve been taking ALA, NAC+, ca-Akg and TMG. I’ve started taking collagen peptides on daily basis in my coffee, just curious if this is enough to activate the Mtor? Should I be skipping it or it’s not significant amount to activate Mtor? Also how much protein on average I should be consuming without activating Mtor? Also do I need to stop taking any of the above supplements? 1 gregg bambu gregg bambu 4 months ago Metformin downgrades MTOR. that's why people who have been taking metformin for years have less disease. 6 lizardfirefighter110 lizardfirefighter110 4 months ago I don’t remember the source, but I learned that 50, 50, 3 was a good guide. 50 grams of protein, 50 grams of carbohydrates and no eating for 3 hours before bed. I was thinking 8 for hours of sleep and so it would be 50 50 3 8. I am hoping someone will come up with some more numbers.😉 1 ディアラン ディアラン 4 months ago it really comes down to: everything in moderation. 1 💰Happy888💰 💰Happy888💰 4 months ago Very interesting thank you 💫🔥💯✔ 2 helen mary helen mary 4 months ago Go David! 3 A L A L 4 months ago Im wondering if Pea protein is an alternative to whey to limit mTOR activation? 3 Yolie Giraldo Yolie Giraldo 4 months ago Excellent 🤩🤩🤩🤩 1 Ben Steele Ben Steele 4 months ago Many things will downregulate mTOR: exercise, fasting, low-carb diet, etc. Sinclair is partly wrong about one statement. Amino acids only upregulates mTOR to a high degree and for long periods on a high-carb diet. It's the carbs that creates the conditions for that mTOR response to amino acids. This does not happen on a low-carb diet where mTOR doesn't go up as much or for as long. This is partly the impact of having greater levels of ketosis, as is also true with exercise and fasting. On a low-carb diet, one goes into ketosis quickly and similarly mTOR goes down more quickly. So, don't necessarily limit protein but for certain limit carbs. 7 Matthew McMahon Matthew McMahon 4 months ago Not good news for the bodybuilding era, where it is common to eat 7 meals a day and push your body to extremes every day. 2 Theptat Laopiam Theptat Laopiam 4 months ago Hi Sinclair .How you think about plasma exchang Peggy Ferrera Peggy Ferrera 4 months ago Happy Thanksgiving!! 🍗🦃🦃🍗🍗🍗🍗🦃🦃🍗🍗 1