Is Aging Reversible? A Scientific Look with David Sinclair

Is Aging Reversible? A Scientific Look with David Sinclair | David Sinclair | TEDxBoston 97,890 viewsMar 15, 2022 TEDx Talks 34.5M subscribers NOTE FROM TED: Research around aging discussed in this talk remains an ongoing field of study. Please do not look to this talk for health advice. TEDx events are independently organized by volunteers. The guidelines we give TEDx organizers are described in more detail here: http://storage.ted.com/tedx/manuals/t... Have you ever wondered how long you will live? And if so, how could you change that number to live drastically longer? The science might be in your favor: follow David Sinclair, Australian biologist and professor of genetics at Harvard University, as he shares his research on slowing and reversing the process of aging in mice, and how the same technology may someday be transferable to humans. David Sinclair, Australian biologist and professor of genetics at Harvard University, shares his insightful research into the science of age reversal and anti-aging medicine. David Sinclair, Australian biologist and professor of genetics at Harvard University, shares his insightful research into the science of age reversal and anti-aging medicine. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx 230 Comments 230 Comments I wish aging would get cured in the next 20 years. ) My right eye has a crushed optic nerve (caused by high IOP (intra occular pressure)) - which has resulted in about 5% vision in my right eye ( practically useless). At the 12 minute mark David talks about treatment that reprogrammed a mouse's optic nerve to regenerate. I would gladly volunteer for such a study - I mean, what do I have to lose - the vision in my right eye is already gone. I wish my comment ( much like, a "message in a bottle"), would find its way to Professor Sinclair. This man is one of my heroes. Really helped to solidify my decision to pursue functional medicine and science. 🙌 I like that he just skims over the fact that they have little mini brains that can think and have dreams in a petri dish like it's nothing, lol. I'm like whaaaaat??? Lol. tell me more about that! Researcher can speak to the Petri dishes without offending by telling all the subjects they have a pea-sized brain... The real battle is against fear and hate. Years of stress will drastically shorten one’s life. I just want the option between life and death, nothing more nothing less Adam in the bible lived over 900 years. Due to DNA damage, human lifespan have gotten shorter. Fasting and keeping blood sugar low? Sounds like the Keto OMAD I have been doing for over 5 years!! Follow his voice, not the writing. The 22nd century will need to be about our existence not just as individual, separate organisms, but as collective organisms. We do not exist in a vacuum. The current Corona virus shows us this as does current research on the microbiome. Our living environment as well as our interconnected, interdependent existence with other humans and other species is key to survival. For example, our food depends upon plants that are supported by insects and bacteria. If those contributing causal factors of food production are damaged, so too will our survival be impacted. Our social interconnection matters as well. We exist in a world with tens of thousands of nuclear weapons that can do untold damage including destroying life on earth. Humbly I posit that surviving as a collective organism become our priority. We must hold our place as it were for a time in the future when we can have a peaceful planet that can safely support a smaller population that lives longer and healthier lives. If we can survive this current toxic episode in history we might be able to focus on long life. While a few elite people are at wonderful wealthy institutions such as Harvard, most people are getting inadequate education. It is hubris to think that the elite few with their exquisite research and their billions of dollars will save all us poor people. We need to consider the state of the collective organism now. Right now. For we are in a dangerous and precarious situation. Our oceans are trashed. Our air and water are polluted. Our ‘food’ supply is toxic. Most people are being ground into poor health with long hours of unsatisfactory labor. Our capitalistic system stands on the shoulders of field and factory labor which is exploitative. We are at war all over the planet. Your research is so beautiful. But I must say, unless we address the profound state of collective disease that exists today, what good will it be to stand alone at age 200 individually? Our social existence also has a profound impact on longevity as research shows- babies who are in isolation or deprived of human touch do not thrive. Our genetic existence tells a greater story. The story is that we exist collectively, interconnected and interdependent. Individual existence is a mirage. I sincerely hope this important work will be viewed in context. It is powerful, but without the broader context it will be rendered meaningless. That is the first time i hear Sinclair says that the first person to live to 150 y.o has been born already and all bets are off. He was always very carefull about predictions. That is happening...the revolution of radical life extension The muddled seeder anaerobically greet because bail expectably raise amidst a exotic ring. obscene, venomous eagle He looks like in his 20s even though he's already on his 50s Just talk everywhere and giving empty promises for many many many years but never done anything tangible. Do the right thing to reach 22nd century. 🤣🤣🤣 David is a legend. Hope he lives forever and so do we. Thanks for sharing tour knowledge Half the age, they were three weeks ago ~! This is shocking ~!! Thanks to David I’ve incorporated long term fasting and reduced my insulin levels significantly. I can truly tell that I reversed the aging clock by just those two factors alone. Hormesis is real and it just makes sense. I lift weights more now, cold showers, i don’t feed into a lot of drama like i used to, procrastinate less all in an effort to make sure my stress levels are low. My new focus area revolves around testosterone synthesis to make sure my hormones are balanced appropriately. That too is improving the quality of my life. I wish he would endorse supplement suppliers as we are on our own trying to figure out who to trust otherwise. Goccia Tuskia We need more evidence based progress and Peer Review in Science. Dr David Sinclair has good ideas maybe, but he needs someone to challenge his thoughts and show results in humans. --- we need better markers of aging and human experiments I'm da mouse on da left, yeah ~!! LOLLL wait so this guy is almost 60 per his opening statement???? David is an fine gentlemen, and one smart cookie..... I think it's important not to live longer but BETTER. I wish Dr Sinclair commented on other longevity research out there. that could be very useful for longevity research community Bezos forever This is amazing, wow I take, TRU Niagen, check it out for yourself, on the computer. It's not working David, you look older than what you are :p Resveratrol bs? Mr. David Sinclair has seperate fanbase..he is amazing Darwin must be very curious right about now. lol Long live David Sinclair!!! 청ずらたん This looks so good. I'm so happy for coming generations (or first person already born, maybe in January). Follow the Salt ,It's moves through Walls, Quantum Salt.key to unlocking More DNA even molecular structures. So my future wife's great great grandma hasn't even been born yet Amazing. I’ve been expecting this!! He is modern time god in true sense. May he keep up his awesome work. Waiting patiently for his next podcast. Please David come back soon. Where can I go for an Go David go! i have always known NAD was a key factor, great topic ! Tell the people we need to get used to the idea of farming flesh farms, what would you rather call it Banks.Hearts Livers, etc , your Goal in life is to stay alive, at All costs, Death is not a option, if God doesn't like it . Ask him why he don't die ? Cosmos=quantum potential (Dirac)! Life=molecular one (Dawkins)! Consciousness=memetic one (Dennet) Thanks tted n David...providing this important video also with nepali subtitle.Also request n w;d b grateful if all the videos also with nepali subtitle. And… then there is viruses wow I'm early👽 New or re-upload? Yes sir!!!!! He looks 30 not 55 😆😍 I like him but have to agree that it's not as simple as he makes it look. He literally blocks fellow scientists who criticize him on Twitter instead of trying to rebut their reasonable claims. Hard to take him too seriously after that. Sinclair Nation! We love Sinclair! 🤜🤛🧠🧬 David keeps talking about the same over and over again since several years ago. We need human trials now! Everybody idolizes David…until they realise he is a smooth talker, repeating the same stuff year after year - including that which is apparently disproven. But that’s not to say the field isn’t making rapid strides. And to give David credit, he has made significant contributions to it. But he also profited (to the tune of hundreds of millions) from research that is apparently plain wrong (resveratrol). He can’t admit it or he’d be morally obliged to return the money. is anybody going to mention how he was born in the 60s but looks in his early forties? Will resetting methylation get rid of my freckles, scars, Presbyopia, the enamel erosion on my teeth, the alteration of structural components in ligaments and cartilages and other connective tissues, micro scarring in various organs, the introgression of Virus RNA in to genome making it prone to cancer or improper functioning etc? Aging is reversable. The only reason folks don't live forever must just be silliness, eh?.. This makes me optimistic about the future. 2 weeks ago Even if you were born in the 1950s, this lifestyle and technology is available and doable now. At the least it can extend your health span to live a strong healthy vibrant enjoyable life until very old by today's standards. More likely it will possibly add a decade or even two to your life - again very vibrant years. I like David Sinclairs enthusiasm however there are somethings you should know about him he constantly tries to make a substance that he helped discover more attractive online to buy for longevity even though human trials have not shown it be effective some even showing it to have bad sideeffects at certain doses it's not me who has pointed this to him it's his colleagues who have presented that what happened when he was shown this? he blocked them we need to survive as civilization in order to enjoy this benefits transhumanism is sounding quite nice right now just want to be cured from glaucoma.. wanna live like everybody else.... see the beauty of the world clearly and work. Hope cure for glaucoma is here.. like now..thank u Dr.Sinclair and team With tech, we might just be able to enjoy aging and not endure it. leaves the industry, we can finally accelerate the research of age reversal therapies. Where are we in terms of solving Alzheimer’s Cancer ect ? I wish he would address Dr. Brad Stanfield’ assertions. Been taking and gifting NMNs for a while now, even to people I don't really like XD He's 52! I'm 70 and I follow his program and it works, I feel like I'm aging backward. SIRT1 protein actively promotes homologous recombination (HR) in human cells, and likely promotes recombinational repair of DNA breaks.[61] SIRT1 mediated HR requires the WRN protein.[61] WRN protein functions in double-strand break repair by HR.[62] WRN protein is a RecQ helicase, and in its mutated form gives rise to Werner syndrome, a genetic condition in humans characterized by numerous features of premature aging. These findings link SIRT1 function to HR, a DNA repair process that is likely necessary for maintaining the integrity of the genome during aging.[61] I am super interested in this science but worry about overpopulation. What David is talking about is LEV = Longevity Escape velocity. If you can hang on for the next 20 years....you will be able to get the technology to add another 10 years of your life. Then within that 10 years....the health tech will be good enough to allow 50 more years to your life...then the next 20 years after that the tech will allow 100 years more...etc....etc. 2 weeks ago Lost my respect for david after he started blocking other very respected scientist on Twitter that were calling him out for using old studies. Yes. No sugar. No refined carbs. No seed oils. Eat animals. Low oxalates. Low lectins. Sinclar takes statins. Enough said. Wonderful This Guy is a Genius, May The Almighty Lord Who Guided You On This Scientific Revelation , let us Live To Witness This Amen 🙏🏿 ❤ David is a nice guy but he is yet to prove if he is on the right track with all these assumptions. Personally I would advise : making protein and high quality fats my priority and avoid plants as much as possible. Also muscle is our best friend and Mr Sinclair has very little. The next 30 years will be interesting so long as the anti meat coalition does not have their way. We will all be long gone before aging is under control. This mans been saying the same stuff for over a decade. Been following this stuff for over 20 years. Guess what at 47, I'm old. We all put hope in these people, and they fail everytime. The fuzzy cloudy peroperatively heat because congo logistically trick in a successful voyage. noiseless, groovy trick Michel Zou Michel Zou 11 days ago We are going to be immortal while still believing in god,socialism and astrology? I don’t believe it,just read some comments in this section. No it's not reversible cause physics going to beat you u Sleep Smart Smash Stress Aging IS NOT Reversible. Any real person with a working brain should be against this. The danger, laziness, and mindset should be enough to have a problem here. These people playing GOD is not a good thing. Are people really this blind? This is exactly what the enemy is going to use to get people on board for transhumanism. I think I will stick with God's plan. I hated everything about this video. Humans are not supposed to live forever. We are animals, brutes. We are FAR hundreds of thousands of years from being ready for this. The worst thing humans can achieve! My right eye has a crushed optic nerve (caused by high IOP (intra occular pressure)) - which has resulted in about 5% vision in my right eye ( practically useless). At the 12 minute mark David talks about treatment that reprogrammed a mouse's optic nerve to regenerate. I would gladly volunteer for such a study - I mean, what do I have to lose - the vision in my right eye is already gone. I wish my comment ( much like, a "message in a bottle"), would find its way to Professor Sinclair. This man is one of my heroes. Really helped to solidify my decision to pursue functional medicine and science. 🙌 I like that he just skims over the fact that they have little mini brains that can think and have dreams in a petri dish like it's nothing, lol. I'm like whaaaaat??? Lol. tell me more about that! Researcher can speak to the Petri dishes without offending by telling all the subjects they have a pea-sized brain... The real battle is against fear and hate. Years of stress will drastically shorten one’s life. I just want the option between life and death, nothing more nothing less Adam in the bible lived over 900 years. Due to DNA damage, human lifespan have gotten shorter. Fasting and keeping blood sugar low? Sounds like the Keto OMAD I have been doing for over 5 years!! Follow his voice, not the writing. The 22nd century will need to be about our existence not just as individual, separate organisms, but as collective organisms. We do not exist in a vacuum. The current Corona virus shows us this as does current research on the microbiome. Our living environment as well as our interconnected, interdependent existence with other humans and other species is key to survival. For example, our food depends upon plants that are supported by insects and bacteria. If those contributing causal factors of food production are damaged, so too will our survival be impacted. Our social interconnection matters as well. We exist in a world with tens of thousands of nuclear weapons that can do untold damage including destroying life on earth. Humbly I posit that surviving as a collective organism become our priority. We must hold our place as it were for a time in the future when we can have a peaceful planet that can safely support a smaller population that lives longer and healthier lives. If we can survive this current toxic episode in history we might be able to focus on long life. While a few elite people are at wonderful wealthy institutions such as Harvard, most people are getting inadequate education. It is hubris to think that the elite few with their exquisite research and their billions of dollars will save all us poor people. We need to consider the state of the collective organism now. Right now. For we are in a dangerous and precarious situation. Our oceans are trashed. Our air and water are polluted. Our ‘food’ supply is toxic. Most people are being ground into poor health with long hours of unsatisfactory labor. Our capitalistic system stands on the shoulders of field and factory labor which is exploitative. We are at war all over the planet. Your research is so beautiful. But I must say, unless we address the profound state of collective disease that exists today, what good will it be to stand alone at age 200 individually? Our social existence also has a profound impact on longevity as research shows- babies who are in isolation or deprived of human touch do not thrive. Our genetic existence tells a greater story. The story is that we exist collectively, interconnected and interdependent. Individual existence is a mirage. I sincerely hope this important work will be viewed in context. It is powerful, but without the broader context it will be rendered meaningless. That is the first time i hear Sinclair says that the first person to live to 150 y.o has been born already and all bets are off. He was always very carefull about predictions. That is happening...the revolution of radical life extension The muddled seeder anaerobically greet because bail expectably raise amidst a exotic ring. obscene, venomous eagle He looks like in his 20s even though he's already on his 50s Just talk everywhere and giving empty promises for many many many years but never done anything tangible. Do the right thing to reach 22nd century. 🤣🤣🤣 David is a legend. Hope he lives forever and so do we. Thanks for sharing tour knowledge Don Grey Half the age, they were three weeks ago ~! This is shocking ~!! Thanks to David I’ve incorporated long term fasting and reduced my insulin levels significantly. I can truly tell that I reversed the aging clock by just those two factors alone. Hormesis is real and it just makes sense. I lift weights more now, cold showers, i don’t feed into a lot of drama like i used to, procrastinate less all in an effort to make sure my stress levels are low. My new focus area revolves around testosterone synthesis to make sure my hormones are balanced appropriately. That too is improving the quality of my life. I wish he would endorse supplement suppliers as we are on our own trying to figure out who to trust otherwise. We need more evidence based progress and Peer Review in Science. Dr David Sinclair has good ideas maybe, but he needs someone to challenge his thoughts and show results in humans. --- we need better markers of aging and human experiments I'm da mouse on da left, yeah ~!! LOLLL wait so this guy is almost 60 per his opening statement???? David is an fine gentlemen, and one smart cookie..... I think it's important not to live longer but BETTER. I wish Dr Sinclair commented on other longevity research out there. that could be very useful for longevity research community Bezos forever This is amazing, wow It's not working David, you look older than what you are :p Resveratrol bs? Mr. David Sinclair has seperate fanbase..he is amazing Darwin must be very curious right about now. lol Long live David Sinclair!!! This looks so good. I'm so happy for coming generations (or first person already born, maybe in January). 1 Follow the Salt ,It's moves through Walls, Quantum Salt.key to unlocking More DNA even molecular structures. So my future wife's great great grandma hasn't even been born yet Amazing. I’ve been expecting this!! He is modern time god in true sense. May he keep up his awesome work. Waiting patiently for his next podcast. Please David come back soon. Go David go! i have always known NAD was a key factor, great topic ! Tell the people we need to get used to the idea of farming flesh farms, what would you rather call it Banks.Hearts Livers, etc , your Goal in life is to stay alive, at All costs, Death is not a option, if God doesn't like it . Ask him why he don't die ? Cosmos=quantum potential (Dirac)! Life=molecular one (Dawkins)! Consciousness=memetic one (Dennet) Thanks tted n David...providing this important video also with nepali subtitle.Also request n w;d b grateful if all the videos also with nepali subtitle. And… then there is viruses wow I'm early👽 He looks 30 not 55 😆😍 I like him but have to agree that it's not as simple as he makes it look. He literally blocks fellow scientists who criticize him on Twitter instead of trying to rebut their reasonable claims. Hard to take him too seriously after that. Sinclair Nation! We love Sinclair! 🤜🤛🧠🧬 David keeps talking about the same over and over again since several years ago. We need human trials now! Everybody idolizes David…until they realise he is a smooth talker, repeating the same stuff year after year - including that which is apparently disproven. But that’s not to say the field isn’t making rapid strides. And to give David credit, he has made significant contributions to it. But he also profited (to the tune of hundreds of millions) from research that is apparently plain wrong (resveratrol). He can’t admit it or he’d be morally obliged to return the money. is anybody going to mention how he was born in the 60s but looks in his early forties? Will resetting methylation get rid of my freckles, scars, Presbyopia, the enamel erosion on my teeth, the alteration of structural components in ligaments and cartilages and other connective tissues, micro scarring in various organs, the introgression of Virus RNA in to genome making it prone to cancer or improper functioning etc? Aging is reversable. The only reason folks don't live forever must just be silliness, eh?.. This makes me optimistic about the future. Even if you were born in the 1950s, this lifestyle and technology is available and doable now. At the least it can extend your health span to live a strong healthy vibrant enjoyable life until very old by today's standards. More likely it will possibly add a decade or even two to your life - again very vibrant year I like David Sinclairs enthusiasm however there are somethings you should know about him he constantly tries to make a substance that he helped discover more attractive online to buy for longevity even though human trials have not shown it be effective some even showing it to have bad sideeffects at certain doses it's not me who has pointed this to him it's his colleagues who have presented that what happened when he was shown this? he blocked them we need to survive as civilization in order to enjoy this benefits transhumanism is sounding quite nice right now just want to be cured from glaucoma.. wanna live like everybody else.... see the beauty of the world clearly and work. Hope cure for glaucoma is here.. like now..thank u Dr.Sinclair and team With tech, we might just be able to enjoy aging and not endure it. What happened to the money that GSK paid for resveratrol? If David Sinclair leaves the industry, we can finally accelerate the research of age reversal therapies. Where are we in terms of solving Alzheimer’s Cancer ect ? I wish he would address Dr. Brad Stanfield’ assertions. Been taking and gifting NMNs for a while now, even to people I don't really like XD He's 52! I'm 70 and I follow his program and it works, I feel like I'm aging backward. SIRT1 protein actively promotes homologous recombination (HR) in human cells, and likely promotes recombinational repair of DNA breaks.[61] SIRT1 mediated HR requires the WRN protein.[61] WRN protein functions in double-strand break repair by HR.[62] WRN protein is a RecQ helicase, and in its mutated form gives rise to Werner syndrome, a genetic condition in humans characterized by numerous features of premature aging. These findings link SIRT1 function to HR, a DNA repair process that is likely necessary for maintaining the integrity of the genome during aging.[61] I am super interested in this science but worry about overpopulation. What David is talking about is LEV = Longevity Escape velocity. If you can hang on for the next 20 years....you will be able to get the technology to add another 10 years of your life. Then within that 10 years....the health tech will be good enough to allow 50 more years to your life...then the next 20 years after that the tech will allow 100 years more...etc....etc. Lost my respect for david after he started blocking other very respected scientist on Twitter that were calling him out for using old studies. Yes. No sugar. No refined carbs. No seed oils. Eat animals. Low oxalates. Low lectins. Sinclar takes statins. Enough said. Wonderful This Guy is a Genius, May The Almighty Lord Who Guided You On This Scientific Revelation ,let us Live To Witness This Amen 🙏🏿 ❤ David is a nice guy but he is yet to prove if he is on the right track with all these assumptions. Personally I would advise making protein and high quality fats my priority and avoid plants as much as possible. Also muscle is our best friend and Mr Sinclair has very little. The next 30 years will be interesting so long as the anti meat coalition does not have their way. Incredible to think he’s 76 years old We will all be long gone before aging is under control. This mans been saying the same stuff for over a decade. Been following this stuff for over 20 years. Guess what at 47, I'm old. We all put hope in these people, and they fail everytime. We are going to be immortal while still believing in god,socialism and astrology?I don’t believe it,just read some comments in this section. No it's not reversible cause physics going to beat you up Sleep Smart Smash Stress Aging IS NOT Reversible. SleepSmart SmashStress Aging is NOT Reversible Any real person with a working brain should be against this. The danger, laziness, and mindset should be enough to have a problem here. These people playing GOD is not a good thing. Are people really this blind? This is exactly what the enemy is going to use to get people on board for transhumanism. I think I will stick with God's plan. Cooking My Way I hated everything about this video. Humans are not supposed to live forever. We are animals, brutes. We are FAR hundreds of thousands of years from being ready for this. 3