Longevity - with Valter Longo, and Sinclair

Protein, Fasting, Cancer, and Longevity - with Valter Longo, PhD | The Proof Podcast EP 237 The Proof with Simon Hill 13.6K subscribers Subscribe 786 Share 31,933 views Dec 5, 2022 The Proof Podcast In Episode 237, I’m joined by Dr Valter Longo for an exploration of protein, cancer, the fasting-mimicking diet, IGF-1, and mTOR. 👇 Visit The Proof website for supporting studies and the full show notes 👇 https://theproof.com/podcast/ Regular listeners of The Proof will know that protein is frequently featured in episodes. As an area of nutrition where the scientific community is split, I am interested in digging into the specifics of each viewpoint – and most importantly, the evidence behind each one. Highly requested guest, Dr Valter Longo, returns to the show today to share his position on this contentious topic. Dr Valter Longo is the Edna M. Jones Professor of Gerontology and Biological Sciences and Director of the Longevity Institute at the USC Leonard David School of Gerontology, one of the leading centres for research on aging and age-related disease. Dr Longo is also the Director of the Longevity and Cancer Program at the IFOM Institute of Molecular Oncology in Milan, Italy. His studies focus on the fundamental mechanisms of aging in simple organisms and mice, and on how these mechanisms can be translated to humans. With extensive education and a prominent career, Dr Longo brings an incredibly interesting perspective to today’s conversation. In this episode, we zoom in on terms that have become buzzwords in the protein space, including IGF-1 and mTOR. We discuss protein requirements for different ages, muscle tissue importance, benefits of protein consumption, and potential risks. We also cover the fasting-mimicking diet for both regular folks and as an adjunct cancer treatment. Specifically, we discuss: 0:00 intro 2:58 Ideal diets for longevity 9:15 Important Pathways for aging 16:24 IGF1 Elevation 19:46 Actue vs Chronic elevation of IGF1 25:11 Danger of Protein Over Consumption 32:52 Impact of exercise on IGF1 38:35 Muscle Mass and Longevity 41:59 Study on High Protein Later in Life 48:03 How to get IGF1 tested 49:54 Low IGF1 & Cognitive Decline 53:00 Resistance to IGF1 54:38 Mendelian Randomization Studies 59:21 Fasting Mimicking Diet 1:16:03 Fasting and Cancer 1:27:51 Ketogenic Diet & Cancer 1:32:15 Outro I appreciate having Dr Longo on the show today and hearing yet another perspective on protein, plus much more interesting research and insights. I hope you found this conversation interesting and informative as part of The Proof's exploration on protein. If you're feeling confused or overwhelmed by the amount of information (and partially conflicting stances) The Proof has covered lately, don't fret – I will be releasing a recap and evaluation of this learning soon. Make sure to follow the Proof on Instagram: • @theproof: https://www.instagram.com/theproof/ • @simonhill: https://www.instagram.com/simonhill/ • YouTube: https://www.youtube.com/c/TheProofWit... for the most detailed episode experience. Connect with Dr Valter Longo: • Instagram: https://www.instagram.com/prof_valter... • Facebook: https://www.facebook.com/profvalterlo... • Website: https://www.valterlongo.com/ • His book, The Longevity Diet: https://www.valterlongo.com/the-longe... • Dr Longo’s previous appearance on The Proof Episode 106: https://theproof.com/slow-ageing-figh... The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit http://theproof.com/friends Enjoy, friends. Simon ==== Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit https://theproof.com/friends/ . • The Proof with Simon Hill - https://theproof.com/podcast/ • Book: The Proof is in the Plants - https://theproof.com/book/ • Apple Podcast - https://podcasts.apple.com/gb/podcast... • Spotify - https://open.spotify.com/show/7bAIJCV... • Instagram - https://www.instagram.com/theproof/ • Twitter - https://twitter.com/theproof • Facebook - https://www.facebook.com/theproofwith... • Two week meal plan - https://theproof.com/mealplan/ • Plant Performance - https://theproof.com/plant-performance/ • Use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. Chapters View all 141 Comments rongmaw lin Add a comment... willow05 willow05 3 weeks ago Thank you for this, Simon, you asked all the questions I was hoping you would! I had such doubts about the ‘low protein’ take (sarcopenia, etc) and now it makes more sense, knowing that IGF1 isn’t triggered the same by protein after the age of 65, and also how important resistance training actually comes into play to prevent muscle loss.. major AHA moments! Thank you for all you do, looking forward to more info in this FMD space ! 7 Reply Marcelo Temer Marcelo Temer 3 weeks ago 👏👏👏👏 great interview, Simon asks questions and doesn't hesitate to challenge his own takes on health regarding exercise, proteins and muscle building. Kudos! 6 Reply Blue South Blue South 3 weeks ago A joy to watch ! Congratulations Simon and Walter ! 2 Reply Metal runner Metal runner 4 weeks ago As a croatian living across the pond (Adriatic) from Longo I really share his passion for the taste of fish. However, ethically I can no longer support that industry. Also, how great it is that the longevity expert is called Longo? 22 Reply Jim Patek Jim Patek 3 weeks ago A wonderful podcast as usual. Thank you Simon and team. I am looking forward to Simon's final conclusions and recommendations on protein consumption, especially for older adults who perform regular resistance training to enhance and protect skeletal muscle. At 77, I have a very keen interest in getting this right and I trust that Simon will do just that. It is worth noting that Simon has a 95% Scientific Accuracy score for his The Proof is in the Plants compared to Dr. Longo's 58% Scientific Accuracy Score of The Longevity Diet in the Red Pen Reviews and this tells me that my trust is justified. I only ask that you also consider that our basic metabolic rate drops as we age and therefore our calorie requirements limit the total number of calories we can consume. This must be a consideration when you consider supplementation versus deriving protein strictly from plant based whole foods. It is possible but is it practical? Then there is Leucine. Thank you in advance Simon and team. 6 The Proof with Simon Hill Reply The Proof with Simon Hill · 6 replies Astrid Thomassen Astrid Thomassen 3 weeks ago Thank you very much. I was Looking for more lifestyle longevity tips for cancer survival. I got bc 2 x and still up and running but really would love to hear how to optimise my life. ❤thanks for this information. 3 Reply The Proof with Simon Hill · 1 reply Mary Fullerton Mary Fullerton 3 weeks ago Your podcast is superior and I look forward to it! 2 The Proof with Simon Hill Reply David Weiseth David Weiseth 2 weeks ago Longo is one of my longevity gurus, no question. 2 Reply Sandy Sandy 3 weeks ago Another incredible interview. Thank you Simon for your continued search for the evidence. 3 Reply Plants_and_wellness Plants_and_wellness 2 weeks ago My intuition has always told me that we do not need as much protein as we are being told and I just have always felt that way and then I found an episode of Rich Roll with Dr. Longo and that’s exactly what he was talking about 😄 I look at people like Rich Roll who also believes we don’t need a ton of protein and yet he’s one of the fittest humans alive. Not to mention he looks better than most people half his age. I unintentionally eat the same way he does (smoothie for breakfast, salad for lunch, rice and beans with veggies for dinner) but I do eat fish once a week. Also, Mike Fremont who just turned 100 and still runs everyday, he has ate a vegan diet since he was 69 and he doesn’t consume a lot of protein and yet he seems to still be thriving. He gets protein from beans, he says he eats beans everyday. I love this conversation and I’m so grateful for Dr. Longo for doing this research 🙏 2 The Proof with Simon Hill Reply 1 reply N S A N S A 3 weeks ago Great content Simon!😀🙌lotsa love from Norway Reply Míster Tempeh Míster Tempeh 2 weeks ago I've been increasing my protein consumption and it doesn't feel that healthy, although being it plant-based. I've done that in order to optimize my muscle growth, but honestly, I don't see how it is worth it. I'll just focus more on increasing my training. Thanks Simon and Dr Longo! 2 Reply The Proof with Simon Hill · 1 reply LivinLaVidaPlantBased LivinLaVidaPlantBased 3 weeks ago Fabulous information, thank you! Reply Marcus Ryder Marcus Ryder 3 weeks ago Ive been doing home water fasting for 7 years. Ive you are gradual or progress and over time, you should be fine. Im now at a point where I do 1-2 14 day water fasts per year, and still work (office work). Hard but satisfying and way cheaper than doing in a group or one on one support system. 2 Reply 3 replies Hayden Gladstone Hayden Gladstone 3 weeks ago Around the 35:00 mark, Dr. Longo describes clinical patients completing the FMD 5 days/month and using the Med. Diet (about 1.2g protein/kg) for the remaining days combined with strength training. He describes the female patients following a strength training video for 20 mins (not sure how many x/week) and gaining, in his words, ‘muscle very quickly and easily’. I have been a personal trainer for nearly a decade and have never had clients in their later years gain muscle ‘very quickly’ unless they were completely untrained or an outlier. Were these women frail and untrained to begin with? I would love to hear more about this because this doesn’t compute with my real world experience at all 2 Reply Luc Vandermeeren Luc Vandermeeren 4 weeks ago Fantastic interview. Thank you both. The protein leverage hypothesis states that human beings will prioritize the consumption of protein in food, and will eat until protein needs have been met, regardless of energy content, thus leading to over-consumption of foodstuffs when their protein content is low. If this is true, It would imply that a low protein diet would be difficult for most people to adhere to. Any thoughts on this? 2 Reply The Proof with Simon Hill · 4 replies Talks2squirrels Talks2squirrels 3 weeks ago Great interview. thanks Simon Reply Stephen Turner Stephen Turner 3 weeks ago I think it is possible to see the rda as a rather low value, but also not go overboard with the safety margin. I am 66, so I do try for a little more, but under 100 g per day. 1 Reply Gary Fletcher Gary Fletcher 3 weeks ago Another great interview Simon. These podcasts are definitely challenging my bias 😂 I’ve really enjoyed the Don Layman podcast and now this one. I’m still leaning towards the Don Layman argument but like everything the truth often is somewhere in the middle and Valtor has some very interesting research. One thing that I’m often left thinking is when researchers start talking about risk and reducing risk of cancer, CHD etc. For someone like myself that isn’t particularly good with maths and statistics I’d be interested in future episodes breaking this down. It’s often easy to be very reactive when hearing new information especially regarding diet and lifestyle. Keep them coming buddy 👍🏻 3 Reply Things Youdontwanttohear Things Youdontwanttohear 3 weeks ago Is there an influence of exercise and body fat level on the effectiveness of the fast/fmd? I have seen some very lean, very active people try fmd, but I wonder how much more beneficial fmd is for people like that. Then again it could be even more effective at that level of leaness and conditioning as some time ago I saw a study review video, on Physionic I believe, about how autophagy is limited while fasting in people with more body fat. The same correlation could exist for fmd. 1 Reply 1 reply Stephen Turner Stephen Turner 4 weeks ago (edited) Perhaps the way to 'have your cake and eat it too' is to markedly periodize your training. A phase of hypertrophy training, along with a high protein high calorie diet. Then another longer phase, but use less exercise and food and protein to maintain gains. Then repeat. 5 The Proof with Simon Hill Reply 1 reply Arleen M Arleen M 4 weeks ago (edited) Thanks for the interview. It's been many many years since I had a course in biochemistry. It would seem that there is a fine line between too much protein and not enough according to Dr. Longo. I do long-distance running and I'm wondering if endurance athletes (marathoners and ultra-marathoners) would need as much (or more) protein than than say body builders. How about if we are over 65? Would he recommend the FMD during training for an athletic event? 3 Reply The Proof with Simon Hill · 2 replies Ariel Malanga Ariel Malanga 3 weeks ago Excellent podcast. I utilize the Prolon FMD several times a year. Reply Musicmonsterman Musicmonsterman 2 weeks ago This was very interesting. I first found Valter through Rich Roll and loved that episode. PLEASE bring on David Sinclair for the next episode! Reply J C J C 3 weeks ago (edited) It's good to have these recommendations for precise amounts of protein intake but how do you practically measure this each day? I eat a very varied plant diet and never weigh or record my food. Are other listeners using any particular methods or apps to help with this complicated protein measurement task? Any advice would be very welcome. Looking forward to Simon's summing up of the protein topic. 2 Reply 2 replies Eugenie Breida Eugenie Breida 4 weeks ago I am so glad that I am currently addressing a MUCH simpler and more important factor, for one who eats 'well' (organic, omnivore, meat, greens no potatoes (nightshades are out)), is not/never has been more than 5 pounds over an optimal/lean & mean team athlete type: Regular, reliable SLEEP. Loved Rich Roll's very recent Atomic Habits interview, wherein we learned much about how to clean up our minds and environment for more optimal health. Make your bad habits a lot less convenient, those you'd like to bring in to your being obvious and handy. Obvious. I will listen again, but for now am focusing on being a reliable, deep sleeper/happy camper (having moved all coffee supplies to my basement - inconvenient, bone broth to the front, Wi-Fi on a timer, phone put to bed after dinner/before relax time) There are so many awesome tips, understanding - his interview brings out the best in the author, recommended! (Longo I have listened to for 10 years . . . I am not interested in living LONG, but being healthy. I am very thin, thus Longo's input pretty much goes out the other ear (64yrs female bmi 18 ish. I get the feeling that Longo quickly got his heels in on a position, and I don't see him budging much. I realize this is highly unscientific - hey, I'm an architect - but these thoughts are based on synthesizing a LOT of science, though my late night summaries are obviously casual.) I don't think that enough attention is paid to FEMALE dietary needs/hormones etc. These mice are not over 64yr female critters, those that may be do NOT do well fasted. They die. So . . . I am eating my grassfed lamb, eating veggies w/fiber (they don't help much with calories, thus the meat) and keeping my carbs on the low side - as inflammation is certainly not my friend. 6 Reply 1 reply Foolproof Mastery Foolproof Mastery 3 weeks ago Looking forward to the Q&A episode. Valter recommends going as low as 0.7 g/kg BW at some point which is below the RDA. Considering the worldwide obesity crisis, I'm not convinced that this is a good strategy. Lower protein may equal lower satiety if it's not compensated by increased fibre. The average person may end up eating empty calories in our western world as that's what is most readily available to us. In my opinion, both protein and fibre should be prioritised rather than focusing on the cellular mechanisms and making these extreme recommendations. Muscle mass seems to have some correlation with increased longevity also and it will likely be difficult to build muscle mass eating 0.7 g/kg BW. 1 Reply The Proof with Simon Hill · 9 replies Rafael Rafael 4 weeks ago Vida longa...Valter longo 3 The Proof with Simon Hill Reply The Proof with Simon Hill · 1 reply bigpicturegains bigpicturegains 9 days ago Here’s a thought 💭 Maybe the problem is triggering too much growth under the wrong circumstances. In the context of an unhealthy diet and lifestyle, perhaps signaling for growth is potentially dangerous, as your body isn’t functioning great. However, flip the scrip and turn on growth factors under a healthy context and I am willing to bet results will be very very different. The Proof with Simon Hill Reply The Proof with Simon Hill · 1 reply Rich Vanasse Rich Vanasse 2 weeks ago (edited) It's disappointing to me that there are a lot of studies related to protein as one ages, but no consideration of the efficiency of protein digestion (HCl/pepsin levels and overall digestive/absorption). 1 Reply Petar Đ Petar Đ 3 weeks ago Is it possible that high protein diets don’t impair longevity in people who do resistance training? I heard that IGF1 in that case causes growth in the muscles rather than in the stuff we don’t want. Sorry if you adressed this, haven’t watched all of the video yet 2 Reply The Proof with Simon Hill · 2 replies Olya V Olya V 2 weeks ago Good video. I wonder what the low IGF-1 number Valter is talking about. How low that number should be? Reply The Proof with Simon Hill · 1 reply Angels and Ocean Angels and Ocean 3 days ago 0.7 grams per 1 kg of your body weight. Thank you! I will stick to this plan for now. I am 56. 1 Reply Ukulele Space Station Ukulele Space Station 3 weeks ago I think it would be good to compare to another longevity scientist Luigi Fontana. They seem to agree on many things including protein and igf-1, but Fontana says the question of plant proteins is still unknown. See his response to a comment on this video https://youtu.be/Xo2I1S4WMcs The Proof with Simon Hill Reply The Proof with Simon Hill · 2 replies Angela Davies Angela Davies 3 weeks ago In the gym now listening, noticing weakness from a year ago (aged54), eat Mediterranean w lot of yoghurt. Have lymphoma. Studying edx online Body Hacking: Using exercise physiology to slow Aging with Anne Friedlander. I am Sicilian decent. Conclusion I will stick with my diet and RT for as long as I can. Hopefully soon HRT I will prevent osteoporosis, sarcopenia. My parents and in-laws 80+ eat meat and 3 veg now issues with CVD, T2D, sarcopenia I hope science will enable a quality of life to a quick death. Reply 1 reply Elena Cainas Elena Cainas 2 weeks ago Does any one have the specifics of the FMD done without Prolon? What can one consume those five days? Reply 1 reply SpindlyScoundrel SpindlyScoundrel 3 weeks ago So, I want to do a five day FMD at home, is it in his book? Where do we find out exactly what to do - I understand he didn't want to sell his own product. Reply 5 replies Marc de Car Marc de Car 3 weeks ago Thank you ! Reply lulu64 lulu64 2 weeks ago I have seen many interviews with Dr. Valter Longo....He always brings up fish as a protein for longevity. Can you please address the fact that fish have heavy metals in them mainly Mercury also Cadmium, cromium, nickel, copper, lead and zinc are some others. Why is this not talked about? Thanks Reply Gino Dumitru Gino Dumitru 10 days ago I'm in carnivore diet for 6 months and feel great I don't know how long I will stay but I do this experiment to see how my body react, after 6 years of plant base Reply The Proof with Simon Hill · 3 replies Flaming Basketball Club Flaming Basketball Club 4 weeks ago Another episode on protein it seems. Didn't the podcast have several episodes decided to specifically protein in 2022? Reply The Proof with Simon Hill · 5 replies Ed Harding Ed Harding 4 weeks ago I’m unconvinced, for me a good diversity of quality protein of all kinds and quality fruit and vegetables not a restricted diet. Needs to be quality, no processed foods. 1 Reply The Proof with Simon Hill · 1 reply Marcelo Temer Marcelo Temer 3 weeks ago Maybe bc cancer is a long term developing illness, it doesn't make a lot of difference if the elder eats high protein. Reply KST KST 3 weeks ago (edited) The huge number of proven successes with real cancer patients over many, many years is excellent proof of the science and procedures Valter Longo has established - and I applauded the non-profit basis of his work. No pharmacy companies to bias studies or withhold negative results or seeking huge profit drugs. Valter’s methods are exceptionally cheap to implement and proven in real people. Thanks Simon and Valter for an excellent discussion, sincerely appreciated. 👍 24 Reply Angels and Ocean Angels and Ocean 3 days ago Thank you 1 Reply The Proof with Simon Hill · 2 replies Tark Gun Tark Gun 3 weeks ago (edited) Still don't understand why FMD is better then prolonged fasting. Fasting is way easier. No big deal to have a 5 days fast from time to time, especially if you are fat adapted . Plus you may have some autophagy benefits with zero calories. 1 Reply 3 replies Keefe Weekers Keefe Weekers 5 minutes ago Man, the more you.know, the more confused.you get. One lonegvity doctor says: protein is king, the other one says you.shouldn't eat a lot of protein under 65. Reply Chris Liang Chris Liang 3 weeks ago @Simon, why no questions about Donald Layman's criticism's? Reply The Proof with Simon Hill · 2 replies Cypriano Cypriano 3 weeks ago ok, how to make the bridge in between what dr longo and dr layman say on protein (quantity and quality) and the diet heart hypothesis. how much does saturated fat, apob, cholesterol contribute to the development of heart disease as opposed to processed carbs, or even carbs in general. Does lipogenesis and inflamation from a high carb diet contribute significantly to the formation of arterial plaque. How can we reconcile these 2 seemingly opposite views on nutrition. 2 Reply The Proof with Simon Hill · 3 replies Erica Erica 3 weeks ago Something feels off about this info. I'm gonna do some more research. Reply The Proof with Simon Hill · 1 reply jaghad jaghad 3 weeks ago Why don't you question this guy's data? He's talking about mice studies and then flips over to humans saying that the conclusions from the mice studies are applicale to humans. Why is that? We are not the same species. We don't share the same metabolic system. You should really really question his conclusions. Professor Don Layman and Stuart Phillips are both questioning this guy's conclusions. And also. If we've been eating meat and fat for more that 2.5 million years why would that be bad for us? Go look into Miki Ben-Dor. So much hogwash in the episode with Longo. 2 Reply The Proof with Simon Hill · 1 reply Panes Panes 3 weeks ago Hmmmmm reading the comments so far, I get a whiff of annoyance, frustration and inconvenience that tge darling macronutrient protein is far more nuanced than some folks would like and bias hard to shake off. Protein is drummed into us, no matter what diet we are on. People seem to shout, "you on a plant based diet, your consumption of protein either in inferior (BS) or too little (more BS)". if you are eating varieties of nuts, seeds, wholegrains, starches, beans, lentils, tofu, tempeh, sietan and I mean eating a wide variety as well as fruits and plethora of different veg YOU WILL BE FINE! so.... BREAKFAST: Scrambled tofu with black beans and veggies(think mushrooms, onions, peppers and green peas on whole meal toast, no need for vegan butter either, some soy (with chia or hemp seeds in made to a milkshake) and some peaches/apricots and grapes if needed. LUNCH? Wholegrain noodles, edename, chickpeas, shreddes kale, avocado slices shredded carrot with chili with almond butter, chili and lime dressing, sesame seeds and , soya yogurt with rasperberries and a handful of almonds and flaked coconut, some cashews. Handful of raisens. DINNER? Kidney bean and mushroom curry with almond milk and some coconut milk, with peppers, spinach, some butternut squash and brown rice and green beans with lemon orvlime juice to boost the iron absorption. Extra naan bread or wholemeal bread . Possible green smoothie with bok choi, Pineapple as well if snacking required and oat choc chip homemade no oil cookies. But generally the above will suffice. If my kids eat packets of crisps on their way home sneakily on top of all this who cares!!! This is how my two twin vegan sons eat and the rest of us. They are 14 years, 6 ft, size 10 feet. There ain't no protein deficiency going on, no refined sugars in abundance, carbohydrates to keep them full from starches and legumes/pulses and wholegrains. Eat enough calories yiu get what you need with all x3 macronutrient. If need to lose weight, more veg, cut back in nuts and seeds say to 1oz a day up the starch to keep you full eat your beans! The following day switch up with different combos of greens, veggies maybe oats too Roasted cauliflower and tomatoes etc. So variety is key. Errrr we are fine as vegans who eat PROPERLY. Raterly ever sick and if sick, bounce back very quickly! Then, there's those on a high meat, dairy, egg diet. Is there a chance this maybe too much protein not wrapped up in fibre is taxing for the body? Whether processed or not and i dont know but is the excess saturated fat, cholesterol and haem iron, interplaying here along with various enzymes and compounds produced? Dr Colin Campbell and his caution reductionism springs to mind here as I am sure all these isolated factors play their role together. Eat whole plant food 85% to 100% Excercise and a variety of it and regular Get proper sleep Keep hydrated Engage in social activity Engage in spiritual happiness and meditate Have a hobby Keep toxins/pollution to a minimum Laugh a lot show love and kindness to self and others. Job done! Yes?! It really is simple. Simon, you are doing such wonderful work. Bloody brilliant. Reply Kurt Hanson Kurt Hanson 2 weeks ago the old protein is evil until your 65th birthday then it becomes protective - say on average you lose 1% of muscle mass every year from age 35 - you’ll lose even more annually following a low protein lifestyle. by the time you reach 65 you’ve conservatively lost 1/3 of your muscle mass. no wonder all these protein fearing longevity experts like longo & sinclair already have the muscle mass of a 12-year-old schoolgirl. the hardest thing to do as we age is build muscle why not do everything in your power now to save muscle mass? i’m not talking about eating 6 high protein meals a day & sitting on the couch & constantly stimulating igf1 / mtor - but surely 3 meals a day prioritising protein mixed with lifting heavy things a few times a week will go a long way to mitigate sarcopenia? lastly enough with the blue zones garbage - it’s time for red zones - spend your time researching red zones & why hong kong has the longest average lifespan per capita in the world & they eat the most red meat per capita in the world. 3 Reply 1 reply Jamie Lee Jamie Lee 2 weeks ago Honestly, he doesn’t look healthy to me. For someone who is 55, he looks much older. I’m a firm believer your insides reflect your external appearance. 1 Reply christine bowman christine bowman 2 weeks ago i really wish the interviewer would keep his personal questions and stories out of the interview.i tuned in to listen to the Dr. Longo.just ask the questions,period. Reply The Proof with Simon Hill · 3 replies Talks2squirrels Talks2squirrels 3 weeks ago (edited) Valter was the first person I ever learned about fasting from.. Before he starting selling FMD.. I learned a ton but I don't trust him anymore selling 300 dollar boxes of powdered soup and nuts.. It makes me sad. He is also not aging well. He doesn't look healthy. Looks weathered.. tired. Too much pasta.. 3 Reply 2 replies Taty Work Taty Work 4 weeks ago prof Longo gives me attacks of anorexia :( 1 Reply hiker 2023 hiker 2023 3 weeks ago Quack radar went off a little bit with this guy, but great interview. 1 Extending the Human Lifespan Beyond 100 Years | Lex Fridman Podcast #189 Lex Fridman 539K views 1 year ago Lex Fridman Podcast David Sinclair is a geneticist at Harvard and author of Lifespan. Please support this podcast by checking out our sponsors: - Onnit: https://lexfridman.com/onnit to get up to 10% off … 1,872 Comments rongmaw lin Add a comment... Lex Fridman Pinned by Lex Fridman Lex Fridman 1 year ago Here are the timestamps. Please check out our sponsors to support this podcast. 0:00 - Introduction & sponsor mentions: - Onnit: https://lexfridman.com/onnit to get up to 10% off - Clear: https://clearme.com/lexpod and use code LexPod to get 2 months free - National Instruments (NI): https://www.ni.com/perspectives - SimpliSafe: https://simplisafe.com/lex and use code LEX to get a free security camera - Linode: https://linode.com/lex to get $100 free credit 1:34 - Staying young at heart 5:30 - Bringing people back to life 11:05 - Wearables and tracking health data 20:18 - How to solve aging 30:22 - Why do we age? 35:50 - Genetic reset switch that reverses aging 38:20 - AI in biology 40:52 - Health data 48:58 - Fasting 56:29 - Diet 1:04:40 - Exercise 1:10:01 - Sleep 1:18:29 - Data 1:24:00 - Extending lifespan 1:26:42 - Immortality 1:32:28 - Denial of death 1:35:45 - Meaning of life without death 269 Reply 28 replies Roland Connor Roland Connor 8 months ago I am 67, I lost my brother, the last immediate family member, last year. Suddenly, I have a keen desire to live well into my 90s if not longer. For the first time in my life, I am almost afraid of dying, that, if this is it, I want to experience as much as I can for as long as I can. Thank you Lex and David for a little light in the darkness. 42 Reply 3 replies Lachlan Perry Lachlan Perry 1 year ago I love hearing Dr. Sinclair speak because he always brings up something new. 258 Reply 12 replies Crab of Chaos Crab of Chaos 1 year ago "How nice it is to collect data about a person, to CAPTURE that person" — Lex Fridman, Russian supervillain, 2021 245 Reply 6 replies Thomas Dovell Thomas Dovell 1 year ago You should definitely have Aubrey De Grey next! Arguably the most important individual in the field of biology - the OG of longevity research. On top of that he fits your podcast perfectly as he was AI researcher before he switched to gerontology. He will also very quickly change your mind on this "death is blessing in disguise" nonsense! 148 Reply 21 replies chewyjello1 chewyjello1 7 months ago 2:58 I love that Lex read this poem! I have vivid memories or reading that poem when I was 6 years old proudly to my mother...and then reading it silently to myself and feeling quite proud of how I had grown. 6 really is the BEST age. The age full of wonder, when you first start to peice the world together and search for your place in it. 2 Reply Bogdan Liviu Bogdan Liviu 3 months ago 50:23 to 50:32 - what a sweet moment. Lex and David Sinclair are two wonderful people! 2 Reply Will Howe Will Howe 1 year ago Dang lex has been really killin' the guest lineup lately 452 Reply 4 replies Kenny Fortuin Kenny Fortuin 1 year ago This interview was worth every minute. Great in depth and meaningful conversation Lex. 5 Reply Solas Composer Solas Composer 10 months ago That up at 7am after doing something meaningful is something I resonate with to my core as Lex mentions. For me it's composing soundtracks, it's my highlight times to do so even though, yes it puts me in temporary jet lag, in my opinion it's worth it for the release of passionate art that comes with it. 1 Reply Doug H Doug H 1 year ago David got me interested in longevity. Aubrey de Grey showed me that we know what to do to reverse the hallmarks of aging. I hope you invite Aubrey onto the podcasts as well! 84 Reply 4 replies Anne Tessari Anne Tessari 1 year ago (edited) that was a great interview Lex. I was hooked with the mention of the A.A.Milne poem and didn't stop listening. I went and got the copy of the book my grandmother gave me when I was a child too Found the poem, read it while I was listening and started to tear up too. Makes me like David Sinclair even more. Just bought his book on amazon 2 Reply Mickael Jansson Mickael Jansson 1 year ago Another inspiring interview. Interesting to hear what is going on in the labs and what we hopefully soon can use for a reasonable amount. 4 Reply GoHeartGo GoHeartGo 1 year ago Lex is killing it with this guest! A pop tosis! Cheers 471 Reply 2 replies Luis Rodriguez III Luis Rodriguez III 1 year ago Couldn't have come at a better time! I've been waiting for David to be back on JRE, but having him appear here is arguably an even better treat. Thanks Lex! 4 Reply Frank Spence Frank Spence 1 year ago I love it Lex Fridman is a philosopher as well as a scientist. It always baffles me when I hear people say they don’t like philosophy. To me, philosophy is simply thinking clearly and trying to make sense of things. Anyway, as a philosopher, I wonder if Lex would agree that our appreciation of life, our perspective, ultimately depends on our thoughts, yet we really have no idea where they come from, and certainly no ultimate control over them. But some of us are lucky enough to stumble on wonderful conversations like this one that lead to thoughts that make our lives better. Thank you so much. Reply Jeff Robinson Jeff Robinson 7 months ago Very helpful stuff, thank you guys both so much for the awesome content! And Lex, thanks for the brown noise tidbit. I tried it, and it was helpful in zoning in +/tuning out -. I use white noise with some success, but it’s always nice to have another tool in the focus shed! 🤙🏼🌞 Reply Suzannah White Suzannah White 1 year ago Lex - I'm addicted to your podcasts! Working my way through them all and learning a lot. Thank you for helping me remain curious. 3 Reply 1 reply Some guy Some guy 3 weeks ago Two of the grandmasters of life. Loved it. Thank you for wasting your precious time sharing it 😊 Reply Shane Robson Shane Robson 1 year ago Big love to Grandmothers who raised their grandchildren. 483 Reply 8 replies Arlene Portsmouth Arlene Portsmouth 1 year ago (edited) 🥰 David Sinclair's grandmother experienced the same turmoil that my mother experienced during the second world war and the Hungarian revolution. 😭. It seems like at least once per month my mother would spend the weekend reliving all of the horrors she experienced during that time when the Germans invaded and raped her and everybody was just running with nothing but the clothes on their back with bombs dropping left and right, no stores no food no place to live it's still fresh in my mind. Every time I turn the water faucet on, I am amazed at the luxuries we take for granted! 😭. 👏On the subject matter I am an avid follower of David Sinclair!🏆 5 Reply Matt Graves Matt Graves 7 months ago (edited) This is what I am thinking about pivoting into. As a successful software engineer, would love to apply my domain knowledge to the aging problem. Reply Wendy Polatajko Wendy Polatajko 1 year ago One of the best podcasts I have ever listened to. I have just learned of David Sinclair this week and yourself Lex today. Amazing discussion. Thank you so much! Part 2, 3, 4, 5, 6...? :-) 3 Reply 1 reply Rosie Thompson Rosie Thompson 6 months ago I bought Dr. Sinclair's book "Why We Age and Why We Don't Have To." It's so educative and phenomenal. Through him, I learned about NMN supplement particularly by Vitruvin Health 500mg, it's been a couple of months now as also recommended by a close friend. All I can say is that it’s cost-effective, overwhelming energy is felt, and promotes your overall health...I am looking forward to feel and see the same result in the following years… 1 Reply the experimental creator the experimental creator 1 year ago This conversation was a work of art. I was going to say some of the podcasts have got a bit long recently, and that this one was nice for being a more digestible size, but I think my view on this is uninteresting, the three hour talk with your dad was amazing lex, thank you and much love. 1 Reply Troy Walt Troy Walt 1 year ago David Sinclair, a hero of mine, instead of sport players these are the guys we should support and care about, the ones that will improve our lives. 913 Reply 43 replies Julian Julian 7 months ago Nice podcast as always, dude Sinclair has interesting mission I'm reading his book and recommend it so far. Reply Fabi an Fabi an 1 year ago In my view, your most important or impactful interview yet. Especially since it affects everyone and at the same time is out of scope for nearly all of us. 4 Reply Gareth Durban Gareth Durban 1 year ago As with many engineers, I don't look after myself anywhere near as much as I should. Just want to say thanks Lex, the last few podcasts have really motivated me to try to make small changes to improve my overall health. After all I want to be around to greet our new robotic over Lords 😉 Reply helen mary helen mary 11 months ago So much good! You guys are power plants for the planet....cheers, happy new years! Reply Catherine Ross BA-Fine Art/Ma-Clinical Psychology Catherine Ross BA-Fine Art/Ma-Clinical Psychology 1 year ago Your offering so much with these candidly courageous interviews Lex — thank you so much for all of it … 💪❤️🙏👏💥🤪📚✈️⏰👀🎁💬🎶 Loved that poemmmMmmmmmm… by the 6yo … just wonderful! Reply Delbert Kroupa Delbert Kroupa 1 year ago This was difficult and painful to watch, as my wife and I just lost our son, an only child, to sudden heart failure, on May 2, at 44 years old, leaving a 15 year old daughter. We are both 76 years old. Daniel and his daughter enjoyed time together, walking and talking about issues, gaming, cooking, etc. Still, I am glad that I watched it, and I surely would have shared the link with him, even though we both had Lex on our subscribe list. It pains me to discover that we are on the verge of wearing sensors that would have likely seen the heart failure signs far enough in advance to save him. Daniel worked IT at the University of Michigan, Medical Services, helping to keep all of the software and hardware issues fixed. I am crying once again as I write this. 42 Reply 9 replies Rodman Lu Rodman Lu 1 year ago Wow awesome interview Lex. Seen many interviews with Dr. Sinclair but you really killed it with this and got him to open up about much more, with your great questions and extensive research. 1 Reply Jason S Jason S 1 year ago Wow great interview If you guys can team up and make this interview more digestible to the public 🤯 🙌💪 Reply NYC Vegan NYC Vegan 1 year ago This was time well spent, great interview. 8 Reply Beth Beth 1 year ago Beautiful, insightful, emotional conversation. A BIG fan of David Sinclair’s life’s work. So enjoy your conversations with the 🌍 /universe’s thought leaders. 3 Reply Taylor Wall Taylor Wall 1 year ago It's always a fascinating listen with Mr.Sinclair! Excellent episode, as per usual! 3 Reply Taylor Roberts Taylor Roberts 1 year ago David's Book Lifespan is a great read...a must read imo. Looking forward to listening to this, luv both you guys! 95 Reply 1 reply Dennis Katinas Dennis Katinas 1 year ago Lex, David, you both operate on the level where I’d like to be. This conversation embodies so much of my goals and practices. I can do it for hours, sometimes a few days, but I have a long way to go making it a constant stream. Yet, being right here doing these things, it feels like being at the forefront with you guys. It feels like support. Thank you both. Reply Paradox Art Paradox Art 1 year ago (edited) LEX ! I was waiting for this one... Thanks a lot for all the great work you put into these podcasts. Greatings from Belgium. 3 Reply Andre Steiner Andre Steiner 1 year ago I truly appreciated the podcast and all your (both) philosophical points of view about life… it has been truly an honor… thanks and give us more 2 Reply Siddarth Siddarth 1 year ago Was eagerly waiting for this & boy was it worth it 😬 Thanks Lex ❤️ 1 Reply enovasia enovasia 1 year ago Extraordinary. Beautiful. Riveting conversation. Memorable. Stimulating. Smiled with intellectual pleasure throughout. David Sinclair is a superstar, yet modest and personable with it. 4 Reply W W 1 year ago Lex is Joe Rogan without the Bro Jogan 819 Reply 24 replies cherisun1 cherisun1 1 year ago First of all Lex I want to thank you for sharing your conversations with such amazing brilliant people. In reference to time stamp 5:30.. This made the hair on my neck stand up as tears rolled down my face. I wanted to share my thoughts.. I do believe that all human suffering is caused by wanting thing to be different then what they are, we're always wanting what we can't have. I believe this is a huge reason for our grief, unwilling to except the death as it is reality. A part of me would give my life to bring back my lost loved one "artificial or not" as another part of me questions the moral concept of this. I believe only mentally stable people could enjoy this for what it is "science". With all of this being said I'd like to add that I'm a mother that lost my 14 year old son 3 years ago. I dropped my son off at a sleep over at a friend's house and that boy decided to play with a gun... He shot my son in the chest. I do believe a huge part of moving forward with such a loss is in accepting it. As such a science would interfere with that natural process. Looking forward to many more of your talks and thank you for letting me share! 2 Reply Hieu Hieu 1 year ago Been waiting for this podcast for ages! Awesome work as always :D 2 Reply Gary Swift Gary Swift 1 year ago Wow, that part about eating one HEALTHY meal a day is something I accidentally discovered over the past 10 years. BTW, I'm the same age as Dr. Sinclair, and I look as young as he does. That explains so much about my health situation. I've actually been a little worried about why it makes me feel bleh when I eat more. - Thanks Lex. Keep up the good work. 1 Reply Mihaela Buza Mihaela Buza 1 year ago Your “Ёжик в тумане” doll is not by coincidence on your table for this talk :) And for many others too, of course. Thank you to both of you for this episode Reply TeslaYRacer TeslaYRacer 1 year ago Absolutely amazing , Lex every time I listen to you I get inspired, great guest !! Thank you both so much ❤️🤙🏻🤘🏻👍🏻⚡️⚡️⚡️⚡️ 1 Reply Burman Lab Burman Lab 1 year ago Fantastic guest choice! Love seeing scientists I’ve discovered on separate occasions coming together for an enjoyable and insightful conversation. 14 Reply lnc1210 lnc1210 1 year ago (edited) What a brilliant man, and such a thoughful- thought provoking conversation between you both! Thank you so much for always creating such incredible content in your podcasts! You're one-of-a- kind Lex, always stay that way!♡ Reply Tom Wendt Tom Wendt 1 year ago This type of conversation helps me to examine my choices day by day. Thank you! 16 Reply chribjslaha chribjslaha 1 year ago I've been waiting on this one. Mad respect to Lex and David 1 Reply Jeremy Liquidpsy Jeremy Liquidpsy 1 year ago (edited) nice! one of my favourite guests from JRE. nice to see him on your podcast :) 2 Reply Kelly Skinner Kelly Skinner 4 months ago The problem " for me" about being immortal is that I would be to depressed seeing friends and loved ones die over and over again . It would truly be a curse. Reply Emily Barry Emily Barry 1 year ago YES to stressed plants🌱💪🍇! LOVE this topic (and longevity in general). GREAT conversation LEX and David🙏💜🤗 3 Reply rita the cat rita the cat 1 year ago Lex is getting good at these interviews. It's almost as if he's learned his best to approximate human emotions! Reply Dyllan W Dyllan W 1 year ago Outstanding as usual with David. Great podcast, thank you 1 Reply 1 reply Robin Spiess Robin Spiess 1 year ago Excellent guest! Another interesting guest in the area of biology would be Michael Levin. He held a very interesting TED talk. He is looking into bioelectricity as a sort of programming language for anatomy and regeneration. 2 Reply tommyr tommyr 1 year ago This was such a great podcast Lex, I hope we see more regarding this topic! 1 Reply Compassionate Compassionate 1 year ago One of the most beautiful/optimistic podcasts you’ve done. Amazing to hear why no stressing out makes practical sense from a biology standpoint. 3 Reply 9999classy 9999classy 1 year ago One of the most enjoyable discussions both sides had a lot to give Dr David Sinclair is always a pleasure to listen to your facts 3 Reply On Dray On Dray 1 year ago That was a great refresher on David’s book. There is already an Australian device that can sample a saliva swab and provide very accurate Covid test results in 15 minutes. Telemedicine is definitely going to be a huge industry. What’s going to happen to the GP experience? Reply Ouishi Ouishi 1 year ago Searched for this exact podcast a couple weeks ago, happy to see Lex got David on the podcast, definetly think the ideas David Sinclair is talking about deserves more media attention. Looking forward to watching this :) Reply 1 reply V Babbitt V Babbitt 1 year ago This is perfect timing, very excited to watch. Thank you Lex!! 2 Reply deb smith deb smith 1 year ago what a role model we have in him. i am trying to encourage my grand to get into science. we need more humans like him. 1 Reply 1 reply Rise Above Rise Above 1 year ago Great talk, so intriguing on multiple paradigms. Might be a big ask but Lex, do you think you’ll ever be able to get Ray Kurzweil on the podcast? 4 Reply jeff mcdonald jeff mcdonald 1 year ago Lex has become my favorite podcaster. Thank you Lex for contributing to make the world a better place. 3 Reply 1 reply Man Universe Man Universe 1 year ago This is a great conversation. Totally agree with David about enjoying life whenever you are immortalized or not. 2 Reply František Prokopec František Prokopec 1 year ago A phenomenal conversation. Reply 4Carbide 4Carbide 1 year ago i can also relate to the Fried chicken problem. the healthier i eat the the less tasty fried chicken and carbs tend to become. I still crave pizzas and the occasional ice cream. but fried anything just makes me feel Bleh afterwards. 1 Reply Fourthz 44 Fourthz 44 1 year ago (edited) Awesome! Ive been waiting a long time to see dr David Sinclair on your podcast! You should also have Aubrey de Grey on your podcast. He too is one the most important leaders in the biology of aging (I'd rank him up there along with David). And he has an awesome beard too! 2 Reply 2 replies Bob Wells Bob Wells 1 year ago Absolutely love this interview... David Sinclair is an amazing man but to watch him in total awe listening to Lex is something else. There's so much information in this video it should be pinned to the top of Google search! 😎🙏 7 Reply RandyFrancisMMA RandyFrancisMMA 1 year ago I swear this dude gets younger looking every podcast lol 274 Reply 23 replies Thiird Thiird 1 year ago Getting to know Sinclair a year ago was the single most important person I ever got to know, he made realize that I had to be aware of what I was doing with what I was eating and my general lifestyle in the context of lifespan. Reply John Felix John Felix 1 year ago Amazing interview Lex! Learned a lot with it. 2 Reply Jack Dunning Jack Dunning 1 year ago Lex, the work you do is wonderful. Like David, you are making the world a better place. Thank you Reply Thai Jackson Thai Jackson 1 year ago Thank you for doing these interviews Lex! You guys are amazing humans! 1 Reply Samuel George Samuel George 1 year ago Great work Lex!! Reply Josh Herndon Josh Herndon 1 year ago Thank you for the amazing podcast Lex! As someone that loves philosophy, you should check out Stephen West’s podcast called “Philosophize This!”. It introduced me to the world of philosophy and is also one of the best podcasts I’ve ever listened to. 3 Reply 1 reply Lucy H Lucy H 11 months ago Really enjoyed this interview. Thank you Reply RTeezy RTeezy 1 year ago amazing episode! I really liked sinclair on rogan aswell, very well spoken and super informative 👌 2 Reply Rahul Rahul 1 year ago It's as though you read my mind with the guests you have, your podcast is mind-blowingly good Reply Ana Hirsch-Toth Ana Hirsch-Toth 1 year ago Thank you for the lively and intelligent interview. Congratulations to both of you. Reply Frances Torrey Sirdevan Frances Torrey Sirdevan 1 year ago Hey Lex if you're obsessed with the protein folding problem, you should interview Dr. David Baker at the University of Washington. He's solved it and is epic!! 1 Reply Tryllium T Tryllium T 1 year ago Great conversation! Always good to hear David's insights and knowledge as well as Lex's philosophy! Thanks!!! 3 Reply Woody Sprott Woody Sprott 1 year ago 👍 Great discussion, very informative & interesting! 1 Reply Greg Ustler Greg Ustler 1 year ago thanks Lex for bringing us this podcast, Nothing short of brilliant Reply Underzero Underzero 1 year ago (edited) Well, i almost never comment on videos, but the topics and content of this podcast #189 with David Sinclair were amazing. I really enjoy this types of talks regarding human biology integrated tech, and how we can improved our health based on that concept and data. Hope to see more talks like this one in the future. I thank both for the great work ! 1 Reply FUTUREWA FUTUREWA 1 year ago (edited) Lex is at the top of his game. Excellent interview style. Reply The Renaissance Piper The Renaissance Piper 1 year ago Lex, this is one of the most profound conversations I’ve ever witnessed! 1 Reply 2 replies Barak Rigbi Barak Rigbi 1 year ago Until I heard the this episode I had a definite idea that the contemplation that we are mortals inherently drives meaning to our every moment. I took assurance from the Greek mythology where said that gods are abusing humans because they are jealous of our mortality, as they, the Gods, have meaningless existence because they can’t die. But now, after hearing this episode I realize that contemplating of living forever is IDENTICAL to the contemplation that we are going to die, and that it gives THE SAME meaning to every moment. Because both give time no meaning. Think about that: if you live forever what is the meaning of delaying to tomorrow? Time has no meaning. Tomorrow is identical to today. So when time has no meaning, it’s critical to make the maximum of every moment. Not because it will not come back (mortals meaning of life), but because you can’t escape your eternal present (immortals meaning of life). Thank you Lex and David for this existential epiphany. 16 Reply 1 reply Sven Sorg Sven Sorg 1 year ago So excited to hear from david again! And now even on my favourite 1 Reply jperin001 jperin001 1 year ago I feel the same way Lex. Stay young. You and your guests crystalize my thoughts. Keep on doing what you do. 1 Reply 2 replies Sean Flynn Sean Flynn 1 year ago I think you lead him down the AI/Data route more than I would have liked. I would like to have known what was the reset point limit and what's the trigger... 1 Reply 1 reply TheDude TheDude 1 year ago A brilliant conversation between 2 brilliant men, this was an absolute joy to listen to. 2 Reply Scott McCallum Scott McCallum 1 year ago great podcast, I love listening to David even though it can be quite fruststrating sometimes as we all kind of expect him to come out with some miracle drug where we can live forever. Some really great advice. There is no need for fad training routines, diets etc its all designed to make the people selling them rich and wont help you. Reply Chris Becker Chris Becker 1 year ago Another mind blowing interview. 3 Reply SK. N. SK. N. 7 days ago So glad Sinclair was brave enough to talk honestly about his diet (mostly whole food - plant based). Lex pls consider this, it's based on science & over term the healthiest diet. Reply Drago PXRN Drago PXRN 1 year ago Great podcast!!! ❤️ 1 Reply The Lost Deity The Lost Deity 1 year ago I really like this conversation between you two. Much to be said and glad to have had the chance to hear it. Looking forward to bright minds working to pave way towards an amazing potential (classless benevolent) future! Much Love! Considering, and also being a dreamer here, that we are able to recreate to an extent of our lost ones in digital format with our still evolving technology and understanding. It will be far more advanced in the coming years.. assuming we collectively fight against and best the coming challenges to humanity. Living to "Thousands of years" doesn't sound all that bad to me. Maybe I'll finally find my soul mate. We just got lost in the timing on when to incarnate ;-) Reply Jeff Noël Jeff Noël 1 year ago The David Goggins reference about vegetables was really good haha. (around 1:03:15) Reply Taras Panamarev Taras Panamarev 1 year ago That was an awesome episode! As always :-) 1 Reply Chris Browne Chris Browne 1 year ago Lex, you've dropped some incredible content lately👏. I'd love to see a part 2 with your father when we hit episode #200, please upvote if you agree so he sees!! 4 Reply Aleksa Gordić - The AI Epiphany Aleksa Gordić - The AI Epiphany 1 year ago One of the best podcasts since 2018 - if not the best one. Loved it. Reply Solitude92 Solitude92 1 year ago Great talk, I didn't want this one to end. 1 Reply ML ML 1 year ago Read this guy's book after his JRE appearance. So exciting and I believe it will be standard to live 120 years in the not-so-distant future. 2 Reply 2 replies Jennifer Strahan Jennifer Strahan 6 months ago Lex, I hear you about the doctors but in my experience that is only the doctors that work within the current American insurance system. A few years ago I was frustrated with how dismissive I felt my doctor was so I found a private medical practice focused on wellness that does not take insurance, it is all self pay. They are incredibly attentive and will order ALL the bloodwork. Since I started going there my health and subsequently proformance and looks have improved. My profile pic is recent, no filters and I am 41 so they are doing a great job. Fortuntely they are not expensive either at $80/visit plus the cost of the few prescriptions which my actual insurance does cover for the most part. My insurance also covers the bloodwork they order, it does not cover the supplements I take which I think is penny wise, dollar foolish of insurance companies. Anyway my point being at this present moment in the US there is excellent healthcare for those who can afford it that is based on a wellness model not a sick model. My doctor orders bloodwork every 6 months and I see them every 6 weeks as I have to be monitored for BP for one optional proformance enhancing RX. While it sounds terrible it is only for those that can afford it now, having fewer barriers, one being cost, can be over come over time. At least these things exist. Reply AlexTheZ AlexTheZ 1 year ago (edited) At first I thought David is kinda creepy, but then I heard he is 51 and than I was like oh that's ok he is just another alien on Lex Fridman podcast 👽 Great work, keep it up 💪🏻 1 Reply Double Double 1 year ago His book is great too, and he reads for the audio book version. I highly recommend it 10 Reply Denis Balogh Denis Balogh 1 year ago Hello Lex, have you considered Mark Solms as your guest? I'm just reading a book from him The Hidden Spring: A Journey to the Source of Consciousness. Interesting stuff. Something you might be interested in as well, if you haven't yet come across it. Btw, love what you're doing and who you are. You inspire us geeks ❤️🙏 Reply Robert Schlesinger Robert Schlesinger 1 year ago Very interesting and worthwhile video. An often missed element helpful in longevity is being a careful person, avoiding life problems and medical problems, minimizing risk, avoiding foolish people that will jeopardize your welfare, and having a backup plan for life's situations making them failsafe. In short,, being careful and avoiding accidents goes along way to increasing life expectancy. 2 Reply Chris Chris 1 year ago Amazing! I had that poem on a height wallchart when I was a kid (but in the present tense). Never knew it was A.A.Milne! Reply samuelec samuelec 1 year ago Beautiful interview, thank you both 2 Reply Juan Varela Juan Varela 1 year ago Lex, this podcast is incredible. Bravo! Reply 3 replies Azam Khan Azam Khan 1 year ago Can we just appreciate how well he explains those concepts with analogies. One of my favorite podcasts already. 7 Reply 1 reply Kenny Bush Kenny Bush 1 year ago From: Shawbay I think you are amazing! You can achieve the unthinkable,hope to share in your journey and add input whenever needed for possible outcomes! Thank you! Reply hi hi 1 year ago Simply Briliant! Kudos lex Reply AD BC AD BC 1 year ago (edited) It would be such an unbelievable resource to be able to interact in real time with people who are no longer alive….. it would be amazing! This is one of the best videos… so interesting. Thank You! 🌀♥️🌀 Reply John John 1 year ago Great choice of people who you interview....keep up your great work. Reply Nilima Mittal Nilima Mittal 1 year ago the way Lex describes his preference to overeat the foods that are good for him vs eating the unhealthy stuff as a cheat is the first time i've heard another person experience this. i am the same way. I get great joy in eating meat till i'm stuffed as a cheat. sweet stuff doesn't taste or smell good to me anymore. I don't even like the mouth feel of most all non meat foods. the feel good chemicals that get released from eating meat till I am physically FULL feels like the biggest cheat meal to me. Reply William Clark William Clark 1 year ago "Speak for yourself, I want this public. Live streamed." Alright that was the best joke you have made so far Lex. Except like half of the whitney podcast holy shit. Keep it up robo joe. 5 Reply MajorCanada MajorCanada 1 year ago The quote to end this was so perfectly timed and brought th conversation so perfectly full circle. Reply 2 replies Chuckie Chocolate Chuckie Chocolate 1 year ago Seems like a very nice, down to earth Gentleman. Thanks for sharing man. Appreciate you. 1 Reply 3 replies carmine petracca carmine petracca 1 year ago what a great interview lex. enjoyed it very much. 1 Reply Zedek Zedek 1 year ago You should get the longevity pioneer Aubrey de Grey on here too! 1 Reply AnotherproblemOn AnotherproblemOn 1 year ago i would have liked to hear David more on the fast of drinking things like milk during fast Reply The Sheekey Science Show The Sheekey Science Show 1 year ago Great interview Lex! I'm really excited to be part of this growing field and the ability to enhance healthspan. 11 Reply 3 replies Mark KLJ Mark KLJ 1 year ago Great man and great podcast too. Reply Eduard Blackbeard Eduard Blackbeard 1 year ago Great podcast. I have 100 more questions now. Pulling all nighters for my passion for Diablo since D2! Nothing wrong with that xD Reply Robert Jules Young Robert Jules Young 1 year ago I read the book, and using the pills for the last 6 months, and I'll continue doing so for at least 5 more years, or till I die. I use about 25 pills a day, mostly vitamins and minerals, plus my regular stuff for high blood pressure etc. I'm planning to live over 100. let's see how it works out for me.... Reply Ha Le Ha Le 1 year ago Great interview. Andrew Huberman had a specialist guest on recently too who said there is no evidence that fasing is effective! So maybe it would be good to have more information as to why fasting is so effective not just saying it has been done by people for thousands of years. No matter, still one of the best interviews I have seen on any podcast. Reply Lukula Magnus Lukula Magnus 10 months ago Great stuff .U used to bike a lot and play squash upto my 30s. I ate once a day then. Now I'm finding my way back. This podcast is a good guide 🥺🤣😃💪. Da. Lex🥂 Reply Arlene Portsmouth Arlene Portsmouth 1 year ago 👏YES!!! 48 minutes in and I am convinced that Lex is a genius! 🏆 4 Reply 2 replies tc3375 tc3375 1 year ago Lex would you consider doing a Podcast about Frequencies and health/longevity? You mentioned brown noise also, would you consider doing more about the sounds we hear? Reply Dave Oatway Dave Oatway 1 year ago Great podcast of legends - two of the brilliant people of their generation. I am 76 and walk 5 or more miles every evening - both for cardio and for serious weight bearing on my limbs and spine. In the Army I ran, but haven't since to preserve joints. I like the balanced approach to diet - most of the time serious focus on good habits, but not denying the occasional enjoyment of an old favorite food. Thank you for the discussion. Reply Eriksson Eriksson 1 year ago Thank you for putting timestamps on your videos 🙏 1 Reply Kiyoshi Suzaki Kiyoshi Suzaki 1 year ago This is quite interesting - I am sure various topics covered here may be seem quite random, but there is some theme behind that keeps me curious - perhaps curiosity is the theme - which is like the essence of creativity, life - or childlikeness! (the point it appeared early in the video, and rightfully so) What is also interesting is AI - its impact to our life/society but definitely about its connection to neuro science, biology etc... yet its strong connection to Zen, way of life/ state of being, which to me is about life - or essence of life - and knowing more about ourselves... I am unsure if or how these topics may be processed re health and well-being of our life by addressing physical and mental health and the health of our life/society - in the company I am involved in, but I sense there is connection to these seemingly random subjects - also possibly relating to my never-ending mindless self-talk on youtube. Say, there is randomness in the universe. But we are born out of the dust of the universe - so there must be a theme to be found in that randomness, to make life possible, which is a continuous challenge against the law of entropy. Everything will go into chaos (impermanence) but life is to go against that to find some orderliness out of the chaos. Right.. what keeps me immensely interested is; my/our never-ending curiosity/ childlikeness (hopefully) to explore - as if to learn how to play this game of life - how to live our life the best I/we can. Why not? Have fun! Kio PS What I found interesting is, the topic of fasting here and how we may live life has a connection to the three books I published - NMC re waste elimination/ Lean, NSFM re empowerment and decentralized way of mgmt, and Results from the heart, which also touches on Avatamsaka sutra - as a way of how to manifest our potential... Buddha might have said, life is suffering/pain. So, the life may be seen as a process of going through the pain so that the system (life) has to come out with idea/solution to go beyond - gain, eg through fasting - or meditation or..,any hurdles we may face. For the breakthrough to happen (eg for us to be alive) even seemingly different/unrelated elements has to be "synthesized" (to organize itself by doing whatever is needed) so that the solution is found - this is creativity/ life. It may require strong discipline/will. It is like sila-samadhi-panna to come up with wisdom even to combine seemingly random ideas/ events. Perhaps in 'real' childlikeness is a strong will to resign/accept what is inevitable such that they are in the now to face everything as it comes (more or less) in a very creative way... PS2 .Toward the last few minutes, although I had a view re death as it is the same as life (accepting the state of is-ness), I had a smile like a child for this interesting podcast. Well done, and thank you google/ youtube to read my mind t bring this to my attention. Reply 1 reply dondeezy271 dondeezy271 1 year ago I really enjoyed this episode. David is very encouraging and motivating. Reply 2 replies cryptout cryptout 1 year ago This is the most interesting episode i’ve seen so far. Great interaction and so much information I feel I need to learn more of! 3 Reply Jordan Boulais-Richard Jordan Boulais-Richard 1 year ago (edited) The reason why I am going in bioinformatic! Great conversation! Reply 2 replies Leo Leo 1 year ago I like you Lex. I see you are highly interested in self. Self improvement can be misguided. Never really acting on helping others, but immersed in self. Think about it. Reply The Poker Student The Poker Student 1 year ago I don't know where you find all of these fascinating people but everytime I listen to one of your vlogs I think this is the most interesting person yet till I get to listen to another vlog. Thanks so much for sharing and this is definitely the most interesting person yet! Reply 1 reply GALILEO GALILEO 1 year ago (edited) I think it's really worth mentioning Lex' improvement as an interviewer. I LOVED his philosophical rants while giving his guest a break in speaking and thinking. Really professional! 🙏🏼💯 Reply hi hi 1 year ago David, such an important figure of this century 1 Reply 1 reply João Farias João Farias 1 year ago Would love to see Dr. Valter Longo on the podcast. A professional guitar player turned longevity and diet expert. Would be awesome to see 👌 8 Reply Bluesky7 Bluesky7 1 year ago Another fascinating podcast. I look forward to your podcasts, I can't tell you the amount of joy that these podcasts bring to my life. Thank you for taking the time to educate us all. 2 Reply Gil Fiazon Gil Fiazon 7 months ago 55:00 The nuance here is that feeling good is a subjective term and changes based on the time of day, activity at hand, mood, etc. Pasta will not make me feel good if I’m about to be required to do a lot of physical work. On the other hand, if I’ve accomplished what I need to do for the day and I go for a nice dinner and enjoy a bunch of pasta it makes me feel very relaxed and gives me a great sleep. In that sense, it does make me feel good. I think the key is not to eliminate things you enjoy but to enjoy them at the right time. Reply Salman Salman 1 year ago This was absolutely incredible! 1 Reply J.D. Bradley J.D. Bradley 1 year ago You rock, Lex. Keep up the good work my friend. 1 Reply Third Entity Third Entity 1 year ago I hope David comes again to the podcast. This was too short. Reply 1 reply doja doja 1 year ago (edited) Awesome episode, as always. Dr. Sinclair is one of the coolest scientists out there. I'm waiting eagerly to see the fruits of his labour. 4 Reply mikelCold mikelCold 1 year ago He says things like this is normal. This is insane. Great interview! 1 Reply Rosie Thompson Rosie Thompson 7 months ago For the last few months, I've been taking one tablet each day of NMN-Vitruvin Health supplement. I'm astounded to discover that my metabolism now functions as well as it did when I was a younger. Other outcomes aren't nearly as visible yet, but I saw a significant boost in energy and concentration. I'm going to order another few rounds from their website. It took around just 3-4 days to see a difference. Reply A Phil A Phil 1 year ago Lex hits it on the head in the first 5 minuts. Replace congress with ai evolving congressmen from the past and still voting them in and out. Fantastick! 1 Reply peter malmgren peter malmgren 1 year ago Wired to not get it is absolutely amazing it’s right that’s the part I needed it get. Now it’s making more sense. Thanks for your input Reply Jeremy N Jeremy N 1 year ago (edited) Good conversation, I loved the statement you said about sleep Lex "No, you need to get more love in your life!" ^_^ Reply KD Counseling KD Counseling 1 year ago I try to explain feeling the same as I did when I was younger all the time. I don’t think many people feel this way. 1 Reply Brutus - Raf Brutus - Raf 1 year ago Great interview! I only miss the topic of overpopulation being discussed... 1 Reply Timothy Curnock Timothy Curnock 1 year ago (edited) What a treat. Thank you, both of you great men (six year olds). Reply test test 1 year ago ..or we could be thankful that we live in an age where we have the privilege to be the guests of an incredibly inspiring conversation like this. When I grew up, the equivalent was a talk show host asking a celebrity what their favourite colour is. 1 Reply musicalfringe musicalfringe 7 months ago That "ring from Aura" was predicted nicely by Greg Egan in a short story about the dystopian world of medical inequality created by advanced medical technology. Reply Ese of Epe Ese of Epe 1 year ago Hapoy birthday Dr. Sinclair. Happy to be watching this today. 3 Reply Durks Garage Durks Garage 1 year ago Amazing episode!! Keep up the great work! Reply Michael Trapp Michael Trapp 1 year ago Brilliant conversation. Will remember this for a long time. Thanks! Reply Fabi an Fabi an 1 year ago I wish I could translate this into a shopping list of products, supplements, technology products and more, 1 Reply Rhyle Rhyle 1 year ago One of my favorite episodes 1 Reply 123 123 123 123 1 year ago (edited) the last lines were wonderful, David Sinclair is a living legend Reply Mike Mike 1 year ago “Death smiles at us all; all we can do is smile back.” ― Marcus Aurelius 198 Reply 10 replies May May 1 year ago Well thank you Lex for being a very intelligent and adequate host. It is rare because David participates in many streams and shows and there's always a host who is trying to be smart enough to match David. You did not try that - you just were yourself. This is a token of utmost professionalism. Reply Yūgen Yūgen 1 year ago Man I needed this ever since I got to know about Sinclair. Reply natalie portman fan bundle plan natalie portman fan bundle plan 1 year ago On another note if we can all live forever imagine the productivity of a single human mind constantly learning constantly improving for thousands of years even the most basic human mind will be incomprehensibly advanced imagine what we could do for our species 1 Reply Issy Jas Issy Jas 6 months ago Interesting conversation, I can see a time when there’s likely a breakthrough in helping people live longer. It’s at odds with an over populated world though but I imagine that will be overcome through zero reliance on fossil fuels, changes to diet, less importance on products from farm animals. I’m content with the finality of life as it stands, not sure I have the constitution for too long on this world. Reply Morton Fizzback Morton Fizzback 1 year ago Aubrey de Grey would be a great guest, he was also an AI researcher before switching to biogerotology research 2 Reply Connaissances Sans Frontières Connaissances Sans Frontières 1 year ago What a beautiful interview Thank you gentlemen 6 Reply Ice Chuzzel Ice Chuzzel 1 year ago Thank you. 🙏🏻 Great stuff ! I am a fan now ! 🍀 1 Reply Kyle Ganse Kyle Ganse 1 year ago Will be interesting to hear his results of human studies with his cell reset methodology Reply Get started Get started 7 months ago 1:07:30 a good point about openness to new things, so you can stumble upon them and use them. Reply L R L R 1 year ago Brilliant talk! 1 Reply Yayang Tapir Yayang Tapir 1 year ago (edited) He look younger each day . Even physically he look fit...all toned up!👍 1 Reply 1 reply StuntmanDAN StuntmanDAN 1 year ago I had this tab open for a few days until I had the ability to give it my full undivided attention and boy am I glad. 3 Reply 1 reply Jeremiah Cook Jeremiah Cook 11 months ago (edited) Lex, awesome guest and great interview skills. At minute 57:45 David says this more or less, I shortened it a bit [begin paraphrasing — The best bang for the longevity buck is to do both well, eat less often and eat the right things . You gotta live life , what’s a long life if it’s not enjoyable . So indo have a dessert now and then. But anyway… The data says that plant based foods will be better than meat based foods. He also says a lot of people may disagree with him but … —end paraphrasing] Now my family (that loves your content) wants you to stop the carnivore diet. We are thinking you haven’t gone vegan yet, if we are wrong , correct us please. We think you should go mostly vegan or all the way vegan. So many people are following you now and you have an opportunity to change people for the better. Please give veganism another chance if you have already tried and failed. Hire a chef, we think you can afford it. You can do this. There are so many people with active lifestyles that are vegan. I’m not saying you will be a better athlete and you will feel better but my bet is you can be the same athlete and feel just as good. You can do this. If the future of humanity is multi planetary(seems to be something you are excited about talking about) then are we gonna grow animals to eat them on those other planets? Seems a bit difficult and wasteful. Not to mention the extra suffering involved. You are a brilliant person and maybe you are right and we (including David Sinclair) are wrong. I don’t know for sure. But… One idea, work with David Sinclair on a plan and a time period to collect all your biological data in your current state of eating. Then go vegan for whatever time period David recommends and collect the data for that time period. You can keep the calories and protein levels the same and maybe keep the number of times a day eating the same . Then have David analyze it and tell you what has improved or not and how it affects your biological age . Maybe you can prove David’s eating style wrong. Or maybe you can prove the carnivore diet is actually bad for aging. Who knows but my bet is that David is doing what is right. He seems to be a biological genius and wants to live a long healthy life. I guess to really prove anything you need lots of data. But what if the data says carnivore and vegan have same results? Well if that is the answer then just go with vegan to save the planet and the animals. I’m pretty sure going vegan is not worse for your body , or else David wouldn’t be doing it. You can always cheat a little but go mostly plant based . Anyway, it would be cool to see you talk more about something like this. But no matter what, we won’t stop listening to your interviews, best thing on YouTube in my opinion. Keep up the great work!! Reply Mike Nowitzki Mike Nowitzki 1 year ago Been meaning to buy this man’s book, and David is ok too Reply NJ 2 NJ 2 10 months ago David eerily reminds me of Dr. Bruce Banner. I'm waiting for him to get mad and watch him turn into a green hulk. Great talk. Reply Justin Bauer Justin Bauer 1 month ago I'm a fan of sinclair. I've been listening to his podcast and other things with him on it for several months now. From everything I hear him say he seems genuine. But there's some alarming stuff going on that he's tied to. Nmn is a supplement. He talks about it all the time. He takes it. His company/ lab or whatever it is has made a version of nmn, beta nmn. It's just the active version of nmn. Now the fda is talking about banning nmn. I only just started taking nmn this week. And I'm pretty sure I can notice a difference. Seems like my body is recovering better. It would be a shame if they actually ban nmn. David sinclair would be making even more money than he already is if it gets banned. I wish he would say something about this and maybe encourage the fda not to ban nmn. 1 Reply Anti matter Anti matter 3 months ago Can you imagine we have this thinking machine in our pocket? And a major use of this thing is to have vapid relationships for the purpose of attention and validation? Reply Brent Nally Brent Nally 1 year ago Huge thanks to Lex for having David on the podcast! It was EPIC! I interview healthy life extension enthusiasts, host Lifespan News and I'm the CEO/co-founder of Longevity Plan. I'm super focused on solving the human aging problem ASAP! 42 Reply 6 replies musikinspace musikinspace 1 year ago David Sinclair: We've now finally found out how to reverse the biological clock. Normal person: OMG, really? What's the secret? Lex Friedmann: Alright but tell me about protein folding Reply Bautista Baiocchi-lora Bautista Baiocchi-lora 1 year ago Thank you for your hard work lex, saludos loco. Reply martin martin 1 year ago this was one of the most interesting interviews, congrats! also, Diablo3 ? good game! 1 Reply Andrew Kinnear Andrew Kinnear 1 year ago Lex, love your work mate, I would love to pick your brain on your ML experience, would love to see a slightly more in depth technical stuff on your pod cast, but I'm a coder so I would wouldn't I. Just would love to hear your opinion on things like Julia's Symbolic library for instance. please please please? Reply Bandito Bandito 11 months ago If his search for the keys to immortality doesnt pan out, atleast he will be the most knowledgeable person in the world about mice. :) Reply chrishenderson420 chrishenderson420 1 year ago I can see Lex becoming the top podcaster in the world in a few years. Great guest. 43 Reply 4 replies Javad Hashtroudian Javad Hashtroudian 7 months ago I used to work for an enterprise hard disk company. After so many writes near a track the track was read, error corrected and rewrite. Sounds similar to DNA repair. Reply Eric Bettencourt • Ch.2 Eric Bettencourt • Ch.2 1 year ago great interview, Really love listening to DS. and Welcome to Austin Lex! 1 Reply 1 reply Cate true eleven Cate true eleven 1 year ago My doctor has learned to listen to me - knowing my body and understanding my own blood panels - Reply Florian Woelki Florian Woelki 1 year ago David and his book is just awesome! Reply Turn Racing Turn Racing 1 year ago Thank you for the advice on the brown noise, this seriously helps me a lot Reply 3 replies Rishu Kumar Singh Rishu Kumar Singh 1 year ago Wow. Was just hoping that he would call David and boom it's in my recommendation. Thanks LEXU 49 Reply Ben O'Hara Ben O'Hara 1 year ago You're crushing it lately: GSP, Danaher, Sam Harris, now David Sinclair. Keep it up. Reply ORION ORION 1 year ago Sinclair is a gem. Another great one, Lex. 👌🏽 Reply Peter K Peter K 1 year ago thanks Lex! thanks for honesty and thanks for fun :-) Reply Michael Lara Michael Lara 1 year ago I've been waiting over 100 years for this podcast. Reply Matt Clarkson Matt Clarkson 11 months ago I've always thought that the conversation at the end about death perfectly sums up why humans created religion... to help accept & cope with death... Reply SRIIDHAR SRIIDHAR 1 year ago Damn bro, glad I found you from chain-link subreddit. You're inviting the most bomb guests 💯🤩 6 Reply 1 reply Political Fashionista Political Fashionista 1 year ago this channel can easily be turned into a trolling haven. Subbed. : D Reply Mahmoud Soliman Mahmoud Soliman 1 year ago I’m so happy to see he is out of his bubble (I’m sure he is vaccinated… etc.) … I remember vividly when the pandemic hit he took his family to a remote location … asides from the brilliant work he and his team do and the beautiful mental dance this conversation is, this is even more hopeful to a better tomorrow than it looks :) Reply Alexander Anderson Alexander Anderson 1 year ago Quality content. Bravo! Reply Hansu Hansu 1 year ago Curious about the observer and the quest to find the backup copy. Isn't the backup itself for the observer situated in the genome? So when the observer start to malfunction, we can bring a new one recorded somewhere in the DNA? 1 Reply 2 replies Minh Vu Minh Vu 11 months ago Is there any way to activate these genes without putting our body into survival mode? Reply TheDude TheDude 1 year ago 48:30 When Lex cracks a joke its so unexpected, I think I woke my neighbour laughing. 16 Reply sonny H sonny H 1 year ago Thank you❤️🧘‍♂️..for encouragement for living… I gave up in the biggest city, just living healthy way. Reply Mustafa Khan Mustafa Khan 1 year ago Dan doesn't look a day over 40, yet he's 51! He clearly is very knowledgeable about aging. Reply larachellin68 larachellin68 1 year ago Listening to this at 3 am while working on my nightshirt. They are killing me, HELP! 😱😳 2 Reply Shihab RJ Shihab RJ 1 year ago This podcast was amazing😄 Reply 1 reply Sam C944 Sam C944 8 months ago Anyone think Lex could be a supervillian in a marvel movie or something😂 Reply Blaise Dahl Blaise Dahl 1 year ago No way! I just got his book “Lifespan” and was watching some clips when he was on JRE. Been trying to find more recent videos of him. What are the odds? 7 Reply Rotor Blade Rotor Blade 1 year ago (edited) Btw at the beginning of the discussion the question are we the same we were when we were children? I thought about it and came to the conclusion that there may be no identity continuity in time. What if every moment of time the brain simply generates a conscious instance with an unique identity? Imagine making an instant copy of yourself. Then each copy will feel as if it is the same person it was since childhood but the copy can’t have the same identity. So the continuity is simply an illusion because the brain generates a conscious instance based on the information it has and the information is stored from previous experiences. Anyway idk, even if it’s an illusion it’s still better to preserve the thread, I still want people to live longer and healthier Also as David talked about bringing back of Benjamin Franklin, o copy of him would be actually indistinguishable and virtual the same thing as the real human since we may actually copies of a previous moment in time Reply Fabio Dimebag Fabio Dimebag 1 year ago Man thank Odin for these podcasts, I'd be more alone without them. 1 Reply Kevin Smith Kevin Smith 1 year ago "I follow him on Instagram. He's always screaming." - Lex Fridman, 2021 Love you Lex Anytime Dr. David Sinclair speaks, I listen! He is extremely bright and a good soul. God bless him for advancing the field of aging for us. 3 Reply Kowzorz Kowzorz 1 year ago I used to listen to pink noise when I'd code. It's funny the different "colors" of the white noise people prefer. I'd oscillate it so it sounded very ocean like and often played rain on top of it as well. I feel like i'm the only person not particularly bothered by the ring of tinnitus. Reply Kyle Hacker Kyle Hacker 1 year ago (edited) How do I get the latest Bio Sensor? What are the supplements we should take? What are the steps? Too many questions..I appreciate this so much. 1 Reply Richard Lecomte Richard Lecomte 1 year ago "If life were a thing that money could buy, the rich would live and the poor would die" Joan Baez. 1 Reply ARUP SAM ARUP SAM 3 days ago david: Sensors can know when u have sex Lex: speak for yourself I want that data live streamed Reply ₪ jetson ₪ jetson 1 year ago That was a beautiful podcast Reply Alec S Alec S 1 year ago Это прекрасно! 4 Reply Devesh Fuse Devesh Fuse 11 months ago If we record enough video or images of your people you love I think you may somday bring them back in digital space like metaverse using AI. Reply Maciej Glodek Maciej Glodek 1 year ago was listening to this podcast with Takashi Kokubo (小久保隆) - Oasis Of The Wind in the background . Felt like a spiritual experience lol Reply 1 reply TheGeorgee TheGeorgee 1 year ago I have been long waiting for David Sinclair! Made my day. Reply Andrew Andrew 1 year ago Id be interested to hear if theres any information on a hormetic benefit to sleep restriction/deprivation. Reply Film Masters Film Masters 1 year ago Its interesting. Most people can only remember what they where like since the age of 5 or 6. Obviously memory doesn't start saving till that age Reply Starclimber Starclimber 1 year ago Don't get him on twitter...hahahahahah! Excellent talk, gentlemen, and thank you! 4 Reply iou9999999 iou9999999 1 year ago Where Lex asked about data sharing and collection around the 41 minute mark, I wonder if the technology that Ocean Protocol is developing on the blockchain would be useful for this issue Reply 3 replies MajorCanada MajorCanada 1 year ago I can listen to this podcast anytime! Reply Iain Mair Iain Mair 1 year ago Sometimes I wonder if Lex properly prepares himself for these interviews. Sometimes it sounds like he’s winging it. On a side note, I hate typing on a cellphone. 2 Reply Ori Ori 1 year ago Lex you gotta watch Altered Carbon! Would love to hear you talking about that in the context of many of your talks 1 Reply Kim Oz Kim Oz 1 year ago 48:44 “live streamed” best comeback line all day! Reply Cryo Chamber Cryo Chamber 1 year ago Brown noise is interesting, but definitely check out Dark Ambient music as well, lots of writers and creatives use it to great effect 161 Reply 19 replies Dilan Hamawandy Dilan Hamawandy 1 year ago I remember him from jre. This guy is amazing Reply hadar raz hadar raz 1 year ago Bio hacking of the highest level It's not easy listening. It's fascinating Have a great weekend Reply RM RM 1 year ago This was amazing, and if all I had to do was were a "patch" to be monitored.... well I'm in honestly. Reply K V K V 1 year ago wow. brilliant conversation with two scientists/philosophers. Reply K T K T 1 year ago (edited) David Sinclair’s AMA: Age Reversal Breakthroughs, FDA Approval, and Living Forever Peter H. Diamandis 16,470 views Dec 29, 2022 In this Ask Me Anything session, David and Peter discuss the latest age-reversal breakthroughs, getting approval from the FDA, and the possibility of living forever. David Sinclair is a biologist and academic known for his expertise in aging and epigenetics. Sinclair is a genetics professor and the Co-Director of Harvard Medical School’s Paul F. Glenn Center for Biology of Aging Research. He’s been included in Time100 as one of the 100 Most Influential People in the World, and his research has been featured all over the media. Besides writing a New York Times Best Seller, David has co-founded several biotech companies, a science publication called Aging, and is an inventor of 35 patents. Read David’s book, Lifespan: Why We Age- and Why We Don’t Have To: https://a.co/d/85H3Mll This episode is brought to you by Levels: real-time feedback on how diet impacts your health. https://levels.link/peter Consider a journey to optimize your mind and body by visiting http://mylifeforce.com/peter Read the Tech Blog: https://www.diamandis.com/blog Timestamps 00:52 - 01:17 Intro 01:18 - 01:53 Why Hasn't David Been On The Podcast Scene? 01:54 - 04:07 Where Are The Breakthroughs & When Are They Coming? 04:08 - 06:45 Peter's Thoughts On The FDA & The Future Of Medicine 06:46 - 11:05 David Sinclair's Experience Dealing With The FDA 11:06 - 14:07 When Is The Right Time To Show Your Findings? 14:08 - 19:15 Are We Doing It? Are We Going To Live Forever? 19:16 - 22:19 How Are David & Peter Going To Reduce Aging? 22:20 - 23:30 Where Can You Get To Know More About David Sinclair? 23:31 - 24:37 The Human Side Of David Sinclair. 24:38 - 25:19 Outro New to Peter? Peter is on a mission to solve the world’s greatest problems. Named by Fortune as one of the “World’s 50 Greatest Leaders,” Peter Diamandis is a Father, Founder, Philanthropist, Humanitarian, and best-selling author. Peter has gathered over $100m to solve humanity's greatest problems. This show is Peter’s effort to share everything he knows about changing the world. Connect with Peter: Website: https://www.diamandis.com/ Instagram: https://www.instagram.com/peterdiaman.. . Twitter: https://twitter.com/PeterDiamandis LinkedIn: https://linkedin.com/in/peterdiamandis/ Listen to Moonshots & Mindsets on: https://www.diamandis.com/podcast Apple Podcast: https://podcasts.apple.com/ca/podcast.. . Spotify: https://open.spotify.com/show/5Y1NyT6.. . Trailer composed and edited by @abramshaffer Key moments View all 195 Comments rongmaw lin Add a comment... Anthony Hopper Anthony Hopper 1 day ago Great podcast! Thank you for taking the time to put this one together. 1 Reply Iron Maiden Fitness Iron Maiden Fitness 2 days ago LOVE David and totally believe that he is doing everything possible to bring longevity to the masses. You go Professor. 4 Reply Claudia Fernandez Claudia Fernandez 6 minutes ago I love David Sinclair! I really love him because his work Reply Joshua Helman, MD Joshua Helman, MD 2 days ago I sure hope they add Vascular Health to the age reversal X prize. “A man is as old as his arteries.”—Sydenham Happy New Year!!! 7 Reply MIKOLAJ NWRSKI MIKOLAJ NWRSKI 1 day ago Good morning! I am contacting with you because I am very much interested in the topic of sirtuin activation and general antiaging. I have been following various studies for years and have a strong interest in this subject. I have been wondering for a long time about the properties of astaxanthin (specifically, whether it works antiaging or also activates sirtuins). Have you ever done any research on astaxanthin? Is our any information on this subject you could share with me? Thank you very much in advance for your help! Kind regards, Mikolaj Niewirowski 2 Reply Good Phone Good Phone 3 days ago However thank you David Sinclair I believe in science, I believe in your science. 9 Reply Martin L Martin L 2 days ago I have a feeling this will just suddenly hit us the way AI is doing now 6 Reply 1 reply Steve S Steve S 3 days ago Everyone saying you love this guy’s work, remember that when nmn is banned due to david’s lobbying efforts. Snake 28 Reply 6 replies Ligia Sommers Ligia Sommers 4 days ago Love the work of you both ! 2023 of happiness, health , youth and peace 🙏🏻✨🥂🌹🙏🏻 5 Reply 2 replies BDoctorG BDoctorG 23 hours ago i was really surprised he said he is not sure we will have immortality. he has often said we would not just reduce the flow of ageing but be able to reverse it? so makes me wonder if everything i have read and heard is really valid. i hope it is not a pipedream and it will happen in the next 15 years. Reply Remote Viewing Adventures! Remote Viewing Adventures! 2 days ago There is a way to get clarity of safety that is more effective than mechanical instruments/testing, but that will require that scientist recognize and employ the value of intuition. I foresee a future where the most sensitive and trained instruments on earth (certain type of humans) and scientists work together in harmony to make great and highly valued strides. 1 Reply rene rene 1 day ago I havent still seen someone living more than the ordinary lifespan of 120 years maximum. I've never seen someone 150 or 200.exept in dreams 2 Reply RToThe RToThe 3 days ago Didn’t he have the FDA remove NMN from the supplement market by listing it as a drug? 10 Reply 4 replies Paul Hartman Paul Hartman 15 hours ago Imagine what we would have if all military spending had been spent on medical/biotech research. Reply Geza Papp Geza Papp 2 days ago About the FDA, "they are mandated to protect the public". It appears that they relaxed this mandate a bit in the last couple of years resulting in huge profit to some ... 3 Reply 1 reply Lord Mon Lord Mon 2 days ago I'm 51. If I'm going to live potentially another century the technology will get better and better in that century and I would fully expect to life spans to become what we want rather than what we have to accept. 1 Reply Curly Bill Curly Bill 3 days ago (edited) Can someone please explain to me - if scientists know now how to reverse cell age virtually at will, how is it that the absolute best we can hope for is another 50-60 years at most? Surely we will reach LEV long before that? Its almost impossible to think that we wont have completely and comprehensively addressed this 'condition' by 2080. 3 Reply 5 replies adam alexander adam alexander 2 days ago I FOLLOW his protocols for Years! People GUESS IM 15 YEARS YOUNGER than my Birth Cert says! No joke!!😊 1 Reply 3 replies Charles Dick Charles Dick 3 days ago Are there small molecules that can stimulate the expression of the appropriate Yamanaka genes? Reply Hoàng Lê Minh Hoàng Lê Minh 18 hours ago It's absurd that poor countries have little access to cheap life-saving drugs such as antiretrovirals and antimalarials, while in rich countries they are already blah-blah-ing about anti-aging drugs. What a world! 1 Reply David Alonso David Alonso 5 days ago If the FDA is the problem, you should to move to a country that will be easier to go on with all the researchers. The paradigm is absolutely different than the FDA is made for. We need new rules, just imagine... The american pharmacy industry wants a world without diseases? They will try to block anything that attack their profits. Just look for a place that all these ideas could success.... Maybe USA is not the right country 16 Reply 3 replies stephencarlsbad stephencarlsbad 2 days ago @7:16 "The FDA was surprisingly receptive..." Yeah, I bet after you offered hefty kickbacks! 2 Reply 2 replies Sinagtala malaya Sinagtala malaya 1 day ago love david. sinclair 1 Reply sven oscar Hansen sven oscar Hansen 1 day ago (edited) Wow. This is a bit materialistic in it’s scope. Many of live a life where the soul is also a daily experience. And where it’s not simply about extending the material experiences of life. This perspective should be part of the discussion. 1 Reply Mark Lucas Mark Lucas 5 days ago Great update! 2 Reply 1 reply Slickboot21 Slickboot21 22 hours ago (edited) What was it in the cuneiform Sumerian King's list... Something like 14 rulers over a span of 38,000 years. We have some of that genetic, although degraded through the millenia because these rulers created us via their genetic intervention. Or is that just not Scientific enough to base anything on? Reply John John John John 2 days ago (edited) Peter needs to rethink his comments about the FDA in light of the total disaster these poison jabs are causing. Safety was never a priority, profit was the only issue. 10 Reply 1 reply Bingham dogy Bingham dogy 7 hours ago The truth is with this recent economy Everyone needs more than there salary to be financially stable. The the best thing to do with your money is to Invest it rightly because money left for saving always end up used with no returns.... 17 Reply 26 replies logan tauson logan tauson 8 hours ago Love the podcast; though who in their right mind would want to live to 200? Regardless all the tech in the world isn’t going to regrow the desolation we have inflicted on the planet our natural resources & each other. The lost state of humanity is a key ingredient. Long life is part of a healthy species.. dots connected perhaps that’s why we are so afraid of death & for 1st world nations closer to it than any tribal group or simple living people’s. Reply Biff Biff 2 days ago David is about his brand and the $$$ he can milk from it. 3 Reply 2 replies Blue Waters Blue Waters 2 days ago I still believe in plant medicine over anything synthetic.. 1 Reply 1 reply Brook Norton Brook Norton 2 days ago David, Peter, you did not good by not dismissing cryonics out of hand, and even putting a possible positive take on it. I would ask you to keep a curious attitude toward it and never dismiss it until it presents some insurmountable challenge. With the prospect of highly advanced medicine down the road, I don't see any show stoppers. Reply 2 replies Nicholas Traianer Nicholas Traianer 23 hours ago "It runs in my family." XD Reply Mariana Shermer Mariana Shermer 4 days ago Despite the economic downturn,I'm so happy☺️. I have been earning $ 60,200 returns from my $7,000 investment every 13days. 31 Reply 16 replies Natasa Mars Natasa Mars 2 days ago Uauu, Davit turned into Vegan? Smart move👋 Reply J OTowner J OTowner 5 days ago (edited) I suspect that it’ll be something only billionaires, or at least those with over $100 million, can afford. 8 Reply 7 replies Yann Lang Yann Lang 1 day ago Greetings Doctor I am waiting for you to discuss Reply Sam C944 Sam C944 2 days ago Anyone think it would be boring to live forever I know this will never happen but suppose it’s cool to speculate I guess us humans just have the will to survive and not lose everything we’ve accumulated Reply 2 replies patrick anderson patrick anderson 5 days ago Question........ Why do we age? What changes in our bodies to cause us to age? So....do we fix the root of the problem or do we stick with tradition and focus on the systems. Reply 2 replies Norman Ortiz Norman Ortiz 2 days ago I want to live more than 150 years, I'm thinking on 500 years, that will be awesome 1 Reply 2 replies andre messier andre messier 1 day ago Back in the day they were using white powder gold and before the flood they were living to 900 plus year according to the Bible Reply stephencarlsbad stephencarlsbad 2 days ago Sinclair is a liar! He stopped doing his podcast after people started calling him out for influencing the FDA to remove NMN from the supplement market! Check out some of the comments from his videos back in Feb - Mar 2022, click on the sort by mini menu and choose "newest first". Plenty of people calling him out! 4 Reply Steven Welp Steven Welp 1 day ago The 21st Century Durk Pearson. 1 Reply Jacqueline Harris Jacqueline Harris 1 day ago Drink your own koolaid 😂 Reply Ryan Anastasia Quinn Ryan Anastasia Quinn 2 days ago He suffers from split personality by my viewing.... 1 Reply rene rene 1 day ago And all these guys look their age. 1 Reply patrick anderson patrick anderson 5 days ago (edited) If the FDA were to speed things up then one can imagine things would become cheaper. Otherwise wheres the give and take? 1 Reply 1 reply joseph dirnfeld joseph dirnfeld 3 days ago Frankly he hypes so much, I don’t believe 2 Reply Madonna Tolentino Madonna Tolentino 10 hours ago 3:29 - 3:31 Reply Simon Blackburn Simon Blackburn 9 hours ago (edited) Don't forget that he's the reason why nmn was ban because of him. Shame on him , he's no différent than the other , just another crook. Reply mike fugate mike fugate 2 days ago stem cells , come on man what the hell is up with stem cells Reply Music Hearer Music Hearer 54 minutes ago "FDA's mandate is to protect the public..." 😄 😄 Be careful to not repeat lies too often.... Reply Joe Soap Joe Soap 2 hours ago SIGN ME UP!!! :) Reply Clement Mario St louis Clement Mario St louis 2 days ago Aging will be avoided when the traditional diet is removed 1 Reply 3 replies relativityboy relativityboy 3 days ago Really not interested in hearing from Sinclair at this point. 5 Reply Ryan Anastasia Quinn Ryan Anastasia Quinn 2 days ago He doesn't look well 😕 2 Reply Steven Welp Steven Welp 1 day ago The Warriors. Reply willyouwright willyouwright 11 hours ago Last ditch effort to keep a failed business going. All in the name of vanity.. this is not the path to immortality. It's not been done correctly . This is exactly when grey goo get made and some idiot accidentally makes zombie apocalypse.. well done Reply Mauro Sciaccaluga Mauro Sciaccaluga 2 days ago The most botoxed doc on the internet 2 Reply anonymous anonymous 2 days ago Conman 1 Reply CeacNoris CeacNoris 19 hours ago Pinocchio Reply EarthWisdom EarthWisdom 5 days ago Masses amount of poverty and misery and we want these people to endure this for 150 years? Another world is possible. 1 Reply 4 replies Lower Your Bill Ad auto.everquote.com Save money Savings on New Heating & AC Count On Us! True professionals ready to solve your heating and cooling comfort needs. Ad BelRed Energy Solutions Book now 56:00 NOW PLAYING Why Aging is a Disease With David Sinclair | EP #18 Moonshots and Mindsets Peter H. 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