How do mitochondria contribute to health and disease? - Peter McGuire

National Human Genome Research Institute 33.8K subscribers Peter McGuire, Ph.D, is an investigator in NHGRI's Medical Genomics and Metabolic Genetics Branch. Throughout his career, Dr. McGuire has been focused on improving the care of patients with disorders of mitochondrial metabolism. His NIH Clinical Center protocols, the NIH MINI Study, is the first organized effort to study immune function in patients with disorders of mitochondrial metabolism, which aims to demonstrate that these patients can be informative regarding the role of mitochondria in immune cell function. The NHGRI Short Course in Genomics offers science educators the opportunity to hear lectures and receive teaching resources from leading researchers, clinicians and staff. Topics include complex diseases, sequencing technologies, brain and behavior, bioinformatics, gene editing, the human microbiome and ethical issues in genomics research. More: https://www.genome.gov/shortcourse Chapters What is metabolism? 0:26 Multifaceted mitochondria: battery, factory, armory, signal station, assassin Metabolism battery and factory 3:13 Mitochondria and popular culture 7:17 How many mitochondria are in cells? White blood cell -30-100 8:29 Where did mitochondria come from? Endosymbiotic hypothesis 9:04 Why did mitochondria develop? 10:07