The Science Behind Why We Age | Lifespan with Dr. David Sinclair #1 David Sinclair

The Science Behind Why We Age | Lifespan with Dr. David Sinclair #1 David Sinclair 284K subscribers Subscribe 19K Share 437,317 views Jan 5, 2022 Podcast Episodes In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of "ex-differentiation" in which cells begin to lose their identity, and how all of this makes up the "Information Theory of Aging", and the difference between "biological age" and "chronological age" and how we can measure biological age through DNA methylation clocks. #Aging #DavidSinclair #Longevity Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Levels - https://levels.link/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsincla... Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclai... Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante Timestamps: 00:00:00 Introduction 00:03:14 Goal of the Lifespan Podcast 00:07:11 Acknowledgement of Sponsors 00:10:45 Aging is a Controllable Process that can be Slowed & Reversed 00:16:42 Organisms with Extreme Longevity 00:21:47 Genes that Regulate Aging: mTOR, AMPK, Sirtuins 00:21:55 mTOR & Rapamycin 00:24:33 AMP-activated protein kinase (AMPK) & Metformin 00:30:57 Sirtuin Proteins as Epigenetic Regulators of Aging 00:35:33 Ex-Differentiation 00:43:30 Measuring Aging - Biological Age vs. Chronological Age 00:49:30 "No Law That Says We Have To Age" 00:50:33 Episode Summary & Key Takeaways - Why Do We Age? 00:54:00 Information Theory of Aging 00:57:59 Aging is a Medical Condition 01:01:00 Aging Myths - Telomeres & Antioxidants 01:01:55 Options for Subscription and Support Links: Weapon fragments in bowhead whales - https://bit.ly/3eP7rqP Rapamycin extends lifespan in mice - https://go.nature.com/3F0yud3 Targeting Aging with Metformin (TAME) Trial - https://bit.ly/3eU9ABk Metformin improves healthspan and lifespan in mice - https://go.nature.com/3JSRZbs Metformin reduces all-cause mortality - https://bit.ly/3pWNiWc Reprogramming to restore vision - https://go.nature.com/335iysI DNA methylation age - https://bit.ly/3sUAUYB Genome-wide methylation profiles & human aging rates - https://bit.ly/3ETPXnK Reversal of epigenetic aging in humans - https://bit.ly/3eUior3 Danish twins study - https://bit.ly/3eToU13 Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. Chapters View all Explore the podcast 8 episodes Podcast Episodes David Sinclair Podcasts 1,270 Comments rongmaw lin Add a comment... Gadinata Gadinata 1 year ago I have been following Dr. Sinclair since I was 33. I am 30 now. 1.6K Reply 53 replies Edison Ryan Edison Ryan 1 year ago I'm 15 and I'm so fascinated by the forefront research and discoveries in the field of longevity and I'm so glad you started this podcast! Thank you so much, can't wait for future episodes! 33 Reply 5 replies Ricky Connelley Ricky Connelley 1 year ago (edited) So glad he made a podcast! The fact we can listen “for free” to a Harvard professor teach is amazing! We live in cool times for self learning 8 Reply Brent Nally Brent Nally 1 year ago I’m stoked David finally has his own YouTube channel! Let’s all work together to solve aging ASAP! 219 Reply 12 replies Odminey Piju Odminey Piju 1 year ago I am 27 and in the last few years I began to notice, that some of my peers are aging much faster than me. This observation caused me to often contemplate the topic of aging, and when I listened to Dr. Sinclair on Huberman Lab, I subscribed to Lifespan right away. Thank you for your work and for making this information accessible! 31 Reply 5 replies Jeff Middlebrook Jeff Middlebrook 1 year ago Thank God for leaders like David who genuinely want to help mankind. My wife and I are 65 yo and we want life after 65 to be our active second life not a death sentence. We plan to share this information to whomever will listen and become disciples of longevity. 156 Reply 11 replies Zala Reverie Zala Reverie 1 year ago I have been counting down and now this podcast is finally here! I am greatly inspired by you and Dr. Huberman and i'll be forever grateful to Lex Fridman to introducing you both to me. Keep changing the world for the better! <3 499 Reply 11 replies Mike S. Mike S. 1 year ago The same way you feel more justified in taking fitness advice from some one who is visibly in shape, David is 50 and looks 30, and he's been applying his science to himself. Such an inspiring guy 14 Reply 2 replies Adam Adam 1 year ago Dr. Sinclair is a hero. We owe him a debt of gratitude. I have been following him and his work since 2016 like every single week. I'm so glad that there is a podcast now! The only thing that I'm worried might derail this fantastic and groundbreaking research is the political turmoil in the US. We need to make sure that this research reaches fruition no matter what. 11 Reply Tonya Mckimmy Tonya Mckimmy 1 year ago On my last leg of treatment for Lyme Disease. I sincerely thank you and Professor Huberman. Your teachings have given added strength to my hope that helps me carry forward. 28 Reply Simon Foo Simon Foo 1 year ago Excellent way to allow layman like me to understand better about the science behind aging. I have listened many of Dr. Sinclair's talks and interviews but this podcast is really well orchestra to enable viewer to better understand the subject matter. Thank you very very much to both of you. I really enjoy watching it and forget to eat my lunch, which is a good thing to miss! 11 Reply sneakers_guy sneakers_guy 1 year ago Thanks so much for starting this podcast series Dr. Sinclair! Matt's inclusion on this podcast is immediately evident to me to be a great decision, acting as an audience member (in a sense) asking the questions that many of us would in real time. Great format 👍 38 Reply Bill Garner Bill Garner 1 year ago David, I would like to personally thank you for your life‘s work and the work that you are doing in reversing biological aging. As one of your students applying the information gleaned from your research to my personal life and to the lives of the medical practices and companies we serve. All I can say is this is a hell of a lot of fun :-) 76 Reply ャン・ティオカ ャン・ティオカ 1 year ago "...we can control aging very precisely at will. We can speed it up as fast as we want in an animal, and even reverse it. So aging is now controllable." What a time to be alive. 19 Reply 4 replies Volker Hiddemann Volker Hiddemann 1 year ago Thank you Dr. Sinclair for this insanely insightful work that you provide. It’s a pure pleasure to listen. It makes me smile to whiteness the similarities between your and Dr. Huberman’s podcast, knowing of course that he helped to ramp this up. It’s great to have such powerful people see collaborate. Matthew La Plante brings a nice twist to the topic. Highly enjoyable. Looking forward to the following 7 episodes. 3 Reply Microwave Engineer Microwave Engineer 1 year ago The combination of a scientist and a journalist for a podcast is just a match made in heaven. This is gonna be great! 25 Reply 1 reply Shlomi Almoslinos Shlomi Almoslinos 1 year ago Such an educational podcast! Thank you so much for what you are doing 🙏 In your book you mentioned that in Hebrew there is a phrase "till 120" when people greet each other every birthday. We also say in Hebrew "Lechaym" which means "to life" every time we raise our wine and cheers. So, thank you for improving our quality and quantity of LIFE. 4 Reply teddy teddy 1 year ago I cannot wait to see what’s this podcast going to bring to the table! I learned about Dr. Sinclair on Whitney Cummings’ podcast and immediately after I read your book! Fast forward a few days and I decided to study Molecular Science in University to hopefully research aging one day! I cannot express my admiration for you enough! 35 Reply 2 replies Wednes Day Wednes Day 1 year ago I'm sure I speak for all of my fellow science lovers when I say, thank you for doing a podcast. It's so exciting! 😊 33 Reply 2 replies Larmik VonHorshley Larmik VonHorshley 1 year ago I really appreciate Dr. Sinclair and the work h puts into making information so crucial to a long and healthy life available and accessible. The child in me can't help but see The crocodile hunter and The House of Pain guy having a casual conversation about epigenetics. We live in amazing times and are so fortunate that such dedicated people are willing to give so much of their valuable time to share their life's work with the world. I am both filled with gratitude and deeply humbled by this generosity, thank you both so much. 4 Reply Divya Bhatia Divya Bhatia 1 year ago Thank you so much for starting such an amazing podcast and providing amazing information free of cost. You are an amazing researcher, human being and an inspiration. And thanks so much for amazing research you do and for teaching how we can use that information and implement it in our daily lives to make it better. 3 Reply John Judson John Judson 1 year ago Thank you Dr. Sinclair and Mr. LaPlante for your book and now this podcast. When it comes to health, I feel like I have been stumbling around in the dark my whole life. The context and data that you have structured so beautiful is giving me hope that an actual and manageable path to health is within reach. You guys rock! 7 Reply 1 reply Erik King Erik King 1 year ago Please do a season 2! Also, I would like to learn about doctors that are focused on lifespan approaches and therapies. 2 Reply james carpenter james carpenter 1 year ago I would just like to thank you for your courageous efforts in keeping us all healthy and young if possible. I am sure that your grandmother is really proud of you now. I have been following you for several years now and find that Your explanation of your research is down to earth and clear especially for a nonscientist. I truly do hope that when you come out with formulas for the rest of us to take they will be available to all at an affordable price as you have said you would in past talks. NMN sounds very promising. Keep up the great work looking forward to all of your talks and podcast and once again I👏Applaud you 13 Reply Przemyslaw Petka Przemyslaw Petka 1 year ago Wow That was great conversation. I saw your conversation with Andrew Huberman but I found it just too bit complicated for a newbie to digest TBH, but this podcast is different. I feel like you and Matthew have a power to propagate those complex topics to people who have never heard/read about this stuff. Cant wait for the next podcast! Thank you for that! :) 28 Reply Luis Rodriguez III Luis Rodriguez III 1 year ago I'm SOOOOOO happy that we finally have a David Sinclair podcast. Please keep this up, I look forward to the future of the show and the science that it'll teach. 3 Reply Vladimir Ivanov Vladimir Ivanov 1 year ago Awesome first episode! Really looking forward to future episodes. This field definitely needs more popularization to change people's perspective on aging. 9 Reply Longevity Plan Longevity Plan 1 year ago We’re super jazzed David has his own YouTube channel and podcast now! The future is looking great! 70 Reply Xela Klement Xela Klement 1 year ago (edited) I remember about 20 years ago when I still went to school and we didn't have all this great information that is now available online, I often said "aging is just a disease, we could be immortal" and everyone said I was stupid and laughed. Thank you so much Dr Sinclair for your amazing work ! I am looking forward to your future podcasts. 1 Reply 1 reply Jennifer Donnelly-Monte de Oca Jennifer Donnelly-Monte de Oca 1 year ago I loved your book and recommended it to countless other healthcare professionals. Really exciting stuff! This podcast was excellent. I just can't say enough great things about you and your work. I'm so grateful that you are doing this podcast so that everyone can get as excited about these incredible advancements as I am! 15 Reply Jeff Nixon Comedy Jeff Nixon Comedy 1 year ago This is going to be such a powerful podcast. Can’t wait! 133 Reply 1 reply RennieV RennieV 1 year ago Thank you so so much for bringing this to the world. Dr Sinclair, you are a gift! And Mr LaPlante, thank you for the questions you bring to the discussion. It really helps reiterate and clarify the information. Thank you both so so much! 4 Reply Kalimah Rahim Kalimah Rahim 1 year ago Thank you Dr. Sinclair. You came into my life via your work regarding the possible variants of Covid-19 in April of 2020. Omnicron was no where on the horizon. You provided forward thinking then and now. Tremendously excited about your program and looking forward to the next seven. I am sure that there will be another seven after that. Thank you again for your passion and dedication to science. 1 Reply Jennifer Strahan Jennifer Strahan 1 year ago Absolutely amazing. This was more than I had hoped for, so much fantastic, mind blowing information. I cannot wait to be able to test my biological age affordably and often. I am very much looking forward to the subsequent episodes and the upcoming book! Thank you Dr. Sinclair for taking the time out of your very busy schedule to make this happen for all of us, this is truly a gift! 4 Reply Aidas R. Aidas R. 1 year ago (edited) I'm so happy to see the podcast's finally out. Great work you're doing there. I've read the book, seen other shows with Dr. Sinclair and each time I'm a bit worried that maybe I will hear the same stuff again. Nope. Each time there's something new. Something even more detailed, from a different angle, new findings presented and so on. Each time I get another boost of motivation and another boost of optimism about the future of humanity :) really cool stuff and truly mind-blowing! Can't wait for the next episode already. 12 Reply Danovic Danovic 1 year ago Love this! Every bit of knowledge I can get about longevity I'll gladly take. Thank you David, for everyone you do for humanity! 13 Reply Elena Teplushkina Elena Teplushkina 1 year ago I'm very excited about this. I've just finished the episode from Huberman Lab podcast. You and Dr. Huberman briefly touched on the topic of fertility and age-reversing. I would be happy to learn more about it and the protocols women can benefit from to extend their fertility age. Thank you! 132 Reply 10 replies Alain Kelder Alain Kelder 1 year ago So excited for this! After reading Lifespan wanted to keep following the developments and maybe add longevity molecule supplementation to my regimen of IF, exercise, sleep, breathing and cold exposure, but finding it hard to weed out the BS. Looking forward to the latest info from the leading researcher himself! :-D 1 Reply wanderingstar wanderingstar 1 year ago (edited) I've been meaning to watch this video series for a while and I finally got around to it today. Having watched this first video, it got me excited and I'm looking forward to the rest! Thank you Dr. David Sinclair and Mathew LaPlante for sharing this information with the world 🙏 Reply turkishromeo83 turkishromeo83 1 year ago Huberman Lab & Dr. David Sinclar, absolutely the Best of Best 🙌🏼 Thank you so much for sharing all your knowledge for free with us 🙏🏼 14 Reply Rosy Rose Rosy Rose 1 year ago You're absolutely right, age is a disease and we weren't designed to suffer from it, but as our free will dictates, we sometimes miss the target and focus on things that aren't well for us a a species. It is so faith-strengthening to hear this from a super-accomplished geneticist. Reply Ranita azul Ranita azul 1 year ago It's inspiring to see people in the scientific field working towards the wellbeing of people (spreding the word outside the field). Thank you for the wonderful work! It will have a huge impact on people :) Here to learn! Greetings from Monterrey, Mexico :) 4 Reply Drew Moon Drew Moon 1 year ago Congratulations on your official appreciated podcast. As an Aussie living abroad, you are a guiding light of inspiration. Thank you, Mate! 25 Reply Cat Steinhilb Cat Steinhilb 1 year ago (edited) Thank you both for this … this is immensely valuable to all us humans striving to live longer, healthier lives ❤️ 1 Reply Better Humans Better Humans 1 year ago So excited this is finally happening :0. I started your protocol 6 months ago aswell as a few other things and can't wait to start sharing my journey when I get the 2nd bloodtest from Inside Tracker...What I can tell you is I feel incredible....Lets get this train rolling! 5 Reply Dylan Dylan 1 year ago I discovered you thanks to Andrew Huberman, currently reading your book and am hyped for this podcast!. I have a feeling its going to be an amazing one. 20 Reply Sunshine Mittens Sunshine Mittens 1 year ago Yeah!!! 🙌 So stoked you are doing a podcast!! Congrats & I’m thrilled to learn, learn & learn some more about health, longevity & more. Cheers! 🥂 1 Reply Marta Ilieva Rangel Marta Ilieva Rangel 1 year ago Happy New Year David - a long awaited podcast 🙌🏼Thrilled to find out more in the subsequent episodes. Thank you 🙏🏼 10 Reply Satbir Aulakh Music Satbir Aulakh Music 1 year ago Thanks again David. Your book has changed my life and life of hundreds of my patients. I work as a GP in Darwin 18 Reply Brooklyn P Brooklyn P 1 year ago So glad I found this! I plan on listening to more episodes. I’m really interested and invested in my own health as I had a liver transplant and want to live and be healthy as long as possible! Keep up the good work and God bless you for it! 🤗 Reply Jax Naturals Jax Naturals 1 year ago This is an eye opening moment for humanity! Completely enthralled with this and will be waiting for every episode! Subscribed! 1 Reply Heath Company Heath Company 1 year ago I eagerly await every Monday for Andrew Huberman's life-changing podcast. And now you're telling me that I get another podcast on Wednesday? Amazing! 9 Reply Becca Petit Becca Petit 1 year ago Thank you greatly! The fact that aging can be stopped and reversed is amazing! I love that we have geniuses like you David who care to share this information in a simplified educational and applicable way! You and Andrew Huberman are in my top podcast favorites! Thank you again and please keep it up. 1 Reply Belinda Belinda 1 year ago Love the dynamic, having someone to bounce ideas and questions about this topic is important! Thank you both for this platform 🙏 18 Reply Red Pill Lense Red Pill Lense 1 year ago (edited) This is AWESOME! Thank you, Dr. Sinclair, for doing the good that helps humanity. You are God sent! 19 Reply Denis M Denis M 1 year ago Such great information! I’ve followed Dr. Sinclair for about three years, and he has a unique ability to explain deeply complicated concepts in ways I can understand. Great stuff! How to be a happy and capable 80-90 year old is quite a valuable recipe! Reply Zer Howitz Zer Howitz 1 year ago (edited) Covid made me reconsider my life priorities and made me decide to go back to school and study biochemistry and molecular biology. I've read some of your works about the expression of 3 of 4 yamanaka factors in mice and it made want to focus my studies on trying to prolong human life / quality of life. Thank you! I feel like our current lifespans are a bottleneck to our civilization's advancement. Imagine what could be if our greatest minds could live and thrive for 30-40 more years in their prime. 3 Reply Christopher Tan Christopher Tan 1 year ago Can you do a podcast on development of children? The acceleration of aging during puberty seems to be somewhat polar opposite to the idea of fasting during adulthood. What ideas come to mind when we say “skip a meal” to a 25-45 year old vs to a 7 yr old, 13 yr old, etc? How do you think about optimizing health in children that are developing in height, performance, etc? Thank you for all you guys do! 26 Reply 3 replies George Amine George Amine 1 year ago This podcast is going to be a game changer for our species. 4 Reply Chef Grace’s Place Chef Grace’s Place 1 year ago Anyone else wondering if Matt aged backwards in the Horvath clock, too? His skin is flawless! So excited for more episodes. Thanks for doing this guys. 4 Reply 1 reply carpe diem jonah carpe diem jonah 1 year ago (edited) What a great way to go around the mainstream medical establishment and present the greatest research in real time directly to the common man. Your research is benefiting mankind at speeds unheard of, and imagined by the mainstream. The "mainstream" is withering from old age. 18 Reply Farhad Khan Farhad Khan 1 year ago I’ve read Lifespan several times and been eagerly waiting for the latest updates from David Sinclair’s research. So glad to see this podcast. 3 Reply Robert Mariano Robert Mariano 1 year ago I first heard of the book, Lifespan, on the James Altucher podcast at the start of the pandemic. I bought the book and I talk about the concept that aging should be treated as a disease. I like that you have a podcast/ YouTube presence. I appreciate that the emphasis is on living healthier with more solid science Reply Paul o connor Paul o connor 1 year ago I've been so excited about this podcast....Here we go. Love your work David and thanks for bringing us this free information. 13 Reply Dr Gayle Delaney Dr Gayle Delaney 1 year ago HOORAY! At last, Dr. Sinclair is unfettered by interviewers who feel they need to ask the same introductory questions and he is free to move on to the next level of explanation. Matthew is so well-informed and knows how to compliment David's points and how to ask interesting and useful follow-up questions. The lighting and sound are good, and the introduction to and the updating of the work is well thought out. THANK YOU! I shall be able to share these videos with a much broader spectrum of my friends and colleagues while learning more and more! 1 Reply Esdras Almeida Esdras Almeida 1 year ago Learned a lot on this episode, i'm definitely watching all of it! I am facinated on how much science has developed so far about aging and so enthusiastically about researching it. 6 Reply 1 reply LaBetoneta LaBetoneta 1 year ago Excellent, first Andrew, now David, life can't be better! Cheers for science! #scienceRules! 25 Reply Tea LaRee Tea LaRee 1 year ago So glad to bump into your channel from huberman. You make a lot of sense and love the science behind it. I want to live long for my autistic son. I don't care about the cosmetic side of it although that's great. I want to do this so my son has a parent for as long as possible. Thank you for your research and endeavors. 2 Reply mark d mark d 8 months ago Thanks for all the work you do, your research, your book and the podcasts etc. It's much appreciated. 1 Reply sciencensorcery sciencensorcery 1 year ago (edited) This is all very exciting stuff! I would like to hear you speak on the ethical and philosophical ramifications of this. While of course slowing and reversing aging — and certainly preventing disease — sounds great, the idea of everyone living forever honestly sounds pretty terrifying. Not to be a total cynic, but it seems like the turnover of life is an important part of the progress of our species in so many ways. If people suddenly start living indefinitely, no longer leaving jobs or positions of power but just continuing to grow and hoard wealth, how will that affect upward mobility? As those people maintain their power for decades (or centuries?) longer, how much more stagnant could social change and progress become? How will it affect the global ecosystem and climate? What about people in developing countries who don't have access to even the low-cost suggestions you make? Could the ability to deliberately age or de-age a person be used for evil (as a punishment, for instance)? Again, I'm not trying to be overly negative, these just seem like very important questions we should be asking and addressing if this is actually where our species is headed, and I'd be interested to hear what you have to say about it. 30 Reply 6 replies Kotryna Rutkauskaite Kotryna Rutkauskaite 1 year ago Amazing!! I came across this podcast by accident. I read the book one year ago and Im so happy you going to talk on it more and explain and expand it! Excited for the next episode Reply Alexander Toronto Alexander Toronto 1 year ago Thank you Dr. Sinclair and to your colleague for starting your own podcast- I have been following your youtube broadcasts for 2 years now and find it fascinating. If you require any volunteers for your work - I am ready, thank you :) 4 Reply 1 reply GG Brait GG Brait 1 year ago THANK YOU!!! This is awesome! Grateful to my favourite members of the humankind, Lex and Andrew, for introducing Dr. Sinclair to someone like me🙏❤️ 9 Reply The Krevoy Team - Mortgage Professionals The Krevoy Team - Mortgage Professionals 1 year ago Can't tell you how happy I am that you decided to do a podcast/youtube channel Dr. Sinclair...way overdue in my opinion but I also understand you are a SUPPER busy man and so grateful for you 2 Reply Pareto Pareto 1 year ago Read Lifespan and now listening to this. What a great opportunity to solidify the concepts expressed in the book and be up-to-date with new research. 3 Reply Melissa Ebbert Melissa Ebbert 1 year ago Yes!!!!! So excited for this! Just started taking NMN a week ago and have been feeling so full of positive energy and able to focus so much better! Thank you David for sharing more of your mind with us!! 3 Reply 2 replies Fuscia Lilac Fuscia Lilac 1 year ago Very pleased that you are going to share your knowledge and experience with us in the podcast format, Dr. Sinclair! I'm looking forward to learning more and working to optimize my biology and be creative and productive for years to come. Thank you! 1 Reply Natalie Axl Natalie Axl 1 year ago Love you David!! Appreciate all the study and research you do and keeping us in the loop of your discovery 🙏🎊💕 Blessings 🙏 6 Reply Kriz Wang Kriz Wang 1 year ago Congratulations Dr. Sinclair! This podcast is going to be epic 👍 17 Reply 1 reply Michael Shover Michael Shover 5 months ago This is amazing to listen to and see the interaction between the two of you. I remember a few years ago I was taking a microbiology and anatomy and physiology class at the same time. I remember the microbiology class was going in depth of the cell and learning about DNA, genes, and each section of the strand with how they link together with the histones. For some reason I became interested specifically with this and how X differentiating and mutation of cells leads to cancer and the aging of the body. The anatomy and physiology class went into some of this as well because it was the second level of the class which was more in depth of the physiology relating to the anatomy. Reply 1 reply Ventriloquix Ventriloquix 1 year ago I love this so much! How lucky we are to get decades of experience within 1-hour episodes. 1 Reply Asad Asad 1 year ago This is such an amazing thing David has done to fans. It's going to be great! 3 Reply Adam S Adam S 1 year ago Waiting an entire week to hear the next episode is aging me significantly 😂 fascinating stuff and can’t wait to hear more! 12 Reply 1 reply colin young colin young 1 year ago Looking forward to following this podcast. May it be fruitful with a long lifespan. 11 Reply Paul Camdar Paul Camdar 1 year ago This is simply incredible. Thank you Dr. David Sinclair. 25 Reply 1 reply Arthur Berry Arthur Berry 1 year ago Having lost 2 brothers at age 59, l hope to live the years they lost, and what better way than to follow Dr Sinclair and his science...which l am doing, having purchased his book and watching Lifespan podcasts, amongst others devoted to the science. 2 Reply 1 reply Andrea Crouch Andrea Crouch 1 year ago (edited) I’ve been following you for a long time. So happy that this has started. I just wanted to say and I know that you’re well aware, the pharmaceutical companies are going to try to buy you or destroy you. I don’t see any way around it. Thank you so much for everything you’ve done I’m 57 people think I’m 30 Reply Lotfi Bouhedjeur Lotfi Bouhedjeur 1 year ago I'm bursting at the seams with excitement! Dr. Sinclair has an official YouTube channel. I love how assertive he sounds talking about what he knows. 6 Reply Meredith Moore Meredith Moore 1 year ago I went to my hairdresser yesterday, we are in Perth Western Australia, and was telling him all about the first podcast. He's nodding away, I know, I know he says. He rushed out to get his phone and he is listening to Lifespan on Audible. Fantastic! I'm really looking forward to this series. Thank you Dr Sinclair and also to Professor Huberman for your knowledge and making it accessible to the general public. Oh and I love listening to an Australian accent (even though it is very light). Reply Jeen34 Jeen34 1 year ago Hello doctor! I've been waiting for this for a while, really happy to finally see it! My question for you (or anyone on the production team) is: are insidetracker and levels available in Europe? Specifically I'm in the Netherlands, and I would love to try both of them! Thank you for the amazing podcast :) 18 Reply 2 replies Brittney Tan Brittney Tan 1 year ago (edited) I can't wait for the next episode. This topic is near and dear to my heart, i want to live forever, or as long as i am able. I enjoyed the podcast, I never knew you're so funny Dr. Sinclair! 33 Reply Steve F Steve F 1 year ago Would love to hear your opinion about Resveratrol versus Pterostilbene in one of these future podcasts David, given your extensive experience with Resveratrol. Thank you for doing these, they're fantastic and I'm definitely looking forward to your future work to help the lay public like me to make use of this fantastic work. Reply Your English Upgrade Your English Upgrade 1 year ago Excellent stuff! I read the book about a year ago, so I'm really looking forward to finding out what' changed and the greater specifics on how to have a greater healthspan. 2 Reply Milorad Milutinovic Milorad Milutinovic 1 year ago (edited) He finally got his own channel, was much more difficult than to reverse the aging 😂 15 Reply Angelina Boland Angelina Boland 1 year ago Mind blowing ! I have been watching videos about aging process for over a year now and I love every one of your interventions - but this is just mind blowing, the first one in which the concret biological process is so clearly explained ! Great work Reply Stefano Bertini Stefano Bertini 1 year ago È veramente eccezionale , come rappresenti sistemi complessi per la maggior parte degli uomini su questa terra , in un modo semplice e comprensibile . Siamo ad un passo da una rivoluzione per l’umanità , inimmaginabile solo pochi anni fa . Per moltissimi inimmaginabile ancora oggi ! Ho voluto scrivere in italiano , per testimoniare quanto sei apprezzabile David !❤️ I wanted to write in Italian, to testify how appreciable you are David!❤️ Sb Reply Vicky Daisy Vicky Daisy 1 year ago Happy New Year Dr- David Sinclair. Thank you for developing the podcast. Amazing contents to be followed. 14 Reply Better Humans Better Humans 1 year ago Incredible, loved all of it..got some amazing new information for example the HbA1c and how Metformin can help. My levels were at 5.6% when I had my first Insidetracker test done last October so will be interesting to see what they are at soon. Can't wait for the next episode! 3 Reply Peter Peter 1 year ago I have been looking forward for your podcast for a while now and I am happy it is finally here :) thank you and keep changing the world for the better :) 3 Reply Alvaro Mengual Alvaro Mengual 1 year ago AWESOME!!!! I see great success for this podcast! Maybe the Science behind aging got its iPhone moment!!!! Great work guys I can't wait to see future content and the result of future research! By the way your mics sounds great however, the mic captured a little bit of eco form the room. I already subscribe and visit your sponsors so that you guys keep building the podcast. 2 Reply Martina Hollearn Martina Hollearn 11 months ago 'I've listened to all episodes and I LOVED all of them. Dr. Sinclair has a lovely voice for podcasting and it's fun to have the two hosts bounce ideas off each other an guide the conversation. Listening to the episodes have been a major inspiration for my personal and professional life and further motivates me to study neuroscience. Please keep working on new series!! Reply T K T K 1 year ago Dr Sinclair has the rare ability to explain complex science in every day language. He’s absolutely one of my favorites, along with Dr Rhonda Patrick. Looking forward to future episodes! 1 Reply Kunal Singh Rathore Kunal Singh Rathore 1 year ago (edited) The wait is over.. My guru is Live. No words can ever comfort me to express my gratitude for all that I have received from life especially from my Guru “Dr.Sinclair”. I have been fortunate to have followed you since the past 4 years and all that I can say is that I am a 37 years chronological getting oldman but who looks like a 27-28 years young & health. It’s because of following you and your lessons on longevity I have been able to successfully reverse my biological age to live a robust & active life till a 100. As Dr.Sinclair once said “The one who will live till 150 has already been born”, I will do my best to be among the set of people who do. In the end can’t wait for your new Book and listen to the remaining 7 episodes of this podcast series. I bow before you for all that you have taught me.🙏🏻 3 Reply 1 reply Zafrat Zafrat 1 year ago What a time to be alive!!! My Goodness, I am so grateful to be learning this. Thank you Dr Sinclair and Matthew Laplante. Reply Belaz_YT Belaz_YT 1 year ago Wish you good luck with this new endeavour! I've started reading your book recently, so interesting and fascinating can't wait to learn more 4 Reply Armie Flores Armie Flores 1 year ago I have been following you Dr. D. Sinclair, so excited to hear all brilliant information for longevity and healthy life.Thank you an awesome work with your team and sharing it to us. 2 Reply Diana Kautzky Diana Kautzky 1 year ago This is such a fantastic podcast. Not only have I signed up for athletic greens and inside tracker I listened to the podcasts over and over. They are excellent and I hope I am changing my lifestyle to Live a longer and more quality life. Me wish us for more podcasts to be developed. I’ve listened to all 8! And I want more. 1 Reply alejandra alvarez de toledo alejandra alvarez de toledo 1 year ago Thank you thank you David Sinclair and co host for speaking so clear for us that are not on the scientific world. I was a mother at 44 years so my interest in keeping alive with my best quality possible as long as i can is a huge wish so i can share with my child many things in his adulthood. Hope as what you say, devices and everything else will be more accesible for us in the future, but we can start with what´s in our hands and that i have been reading/listening over the last years and it´s what you talked about on your episode 2 which i loved too. I´m excited for the next episodes!!!!! 1 Reply Sam Patterson, P.A. Sam Patterson, P.A. 1 year ago (edited) Amazing content! Thank you for starting these! Have purchased the book-which is amazing! 15 Reply Bernard Radcliffe Bernard Radcliffe 1 year ago I am looking forward to the next 7 podcasts. And I can't wait for the new discoveries just around the corner that will change everything we know about age related diseases. 3 Reply John Carl Rankin John Carl Rankin 1 year ago Well Done David! I have been following you for years, as you know. Now is exactly the Right Time to help everyone feel better about their future, and the fact that this is All Possible. Looking forward to the next episode! Much Love & Best Wishes Always, brother. 1 Reply tygrera tygrera 1 year ago I am so glad that this is happening, I've been a fan for a long time, absolutely love your book, much love from the Netherlands 6 Reply Andrei Popa Andrei Popa 1 year ago Great episode. Looking forward for more! 2 things should be adressed: How to balance fasting with geting enough nutrients and what foods are the best. What are the foods/extracts that are similar in effect to the substances you recommend. Like is grapeseed extract a good alternative for Resveratrol. I think this would be useful for people in poorer countries. Also, a PDF at the end of the podcast with the main points would be awesome! Keep it up! Live long and prosper! 1 Reply Alex Liu Alex Liu 1 year ago Thank you for your work and sharing this information. This is truly inspiring and please continue to be motivated by helping humankind! 1 Reply Constance Chan Constance Chan 1 year ago It is a bless that the new year starts off with lifespan with Dr.David Sinclair podcast ! 7 Reply Volodymyr Surma Volodymyr Surma 1 year ago Thank you so much for sharing this with us! I’d very much like to also hear your thoughts about ASD, Dr. Sinclair. 1 in 44 children in the U.S. is diagnosed with an autism spectrum disorder (ASD) and this epidemic is global. There is no known single cause for autism spectrum disorder, some say it’s genetics, some say it’s environmental. most children have gastrointestinal, mitochondrial, sensory issues, inability to detoxify and the list goes on. These kids are born with ASD. Please share your thoughts on this disorder, is this related to early aging and can we fix these so called “dirty genes”. As a mother of an autistic 3 years old child, I’m eager to learn more about this and help my child as much as I can. 3 Reply brooklyn brooklyn 1 year ago Way to go David! I've watched many of your interviews on Rogan, and Lewis Howes and Impact Theory, glad to see you made your podcast! Congrats! 3 Reply Ozone Fine Art-Ventures Ozone Fine Art-Ventures 1 year ago Great podcast! This is so exciting to see podcasts like yours, Andrew Huberman, Lex Fridman, and others who are bringing up-to-the-minute science to the general public. Thank you so much for sharing, really enjoyed you on Andrew's podcast, and will be watching/listening to yours weekly now too. By the way, the addition of Matthew LaPlante is a great idea. It's nice to hear the banter as opposed to a singular, lecture style presentation. Cheers! 6 Reply Super Heroes Super Heroes 1 year ago (edited) David Sinclair has helped me be a healthier and younger person since I was in back in 2020. I’ve implemented intermittent fasting and mild NAD+ boosting precursors like NR and NMN and I’ve been consistently using mineral sunscreen as of a month ago. I read his book Lifespan and I’m starting to read the book again it’s such an interesting read and learning about his family, especially Sinclair’s grandmother, Vera’s positive influence and motivation towards his life. I’m 20 now by the way Reply TheQsanity TheQsanity 1 year ago Huge fan of science, huge fan of academia, huge fan of Huberman podcast, and now huge fan of this podcast as well!! So excited for all of this! 1 Reply minister minister 1 year ago So excited! Thanks for doing this! We always needed more ❤❤ 10 Reply Mariclaret Patton Mariclaret Patton 9 months ago I am chronologically 61. Will I be able to benefit from these discoveries and avoid further ex-differentiation? This is so fascinating. I am going to watch the entire series. Thanks you gentlemen! Reply Janis Gailis Janis Gailis 1 year ago (edited) Dr. David, I have been following you for ages already, so happy to see you starting your own Podcast. Looking forward to every moment with you. 2 Reply Sebastian Niemann Sebastian Niemann 1 year ago Amazing podcast 🙏❤️- already looking forward to part 2 5 Reply Milda Goes Wild Milda Goes Wild 1 year ago It's good to have a podcast coming directly from David as opposed to random interviews by others. 3 Reply Catherine Ross BA-Fine Art/Ma-Clinical Psychology Catherine Ross BA-Fine Art/Ma-Clinical Psychology 1 year ago (edited) Bravo — love seeing you here and your fabulous colleague Matt! A match made in Heaven! I can’t wait to hear the valuable info that you/Matt are making this important contribution accessible to average/normal people— I so appreciate your integrity and authenticity Thank you thank you thank you 🙏 2 Reply Steve Lacy Steve Lacy 1 year ago This was a great podcast, thank you ,can't wait for the next one. 6 Reply Kimberly Johnson Pemberton Kimberly Johnson Pemberton 1 year ago (edited) Complicated topic, I need to spend more time on it but you guys did a wonderful job explaining it to someone with no background. I was pretty skeptical on this idea and a lot of doctors online are too. All they need to do is listen to your podcast and they will have the background to understand. The better grip the average Joe has on this the better we will have of explaining it to those that don’t want to listen or simply not that interested and are kind of caught up in lifestyles that are killing them rapidly. This springs so much hope for my child’s generation, we can try to extend the life and the quality of it for those that are here with this knowledge and let us live out the rest of our life with a higher quality, by my child’s generation or his children’s children we’re going to see some really serious changes with this knowledge. I wish I could peek into the future 200 years from now then again at 1000 and 2000. We may survive this planet yet, all we need to do is stop killing our own through things like the poverty plate lack of healthy and hygienic sleeping conditions materialism and capitalism. If a rich person can build a brand new house after 15 years and tear down the old one why are we sticking people in homes so old they have mold, toxic mold? Greed… The root of all evil. When someone believes they deserve more than others because they have been fed the idea we injure our own species and ensure our demise. You can’t exactly blame the planet for trying to purge us now can you, not if we can’t get our shit together. 1 Reply Rosiana EO Rosiana EO 5 months ago Very insightful Professor, “we owed it to our family and society to be as healthy as possible.” 🙏 Reply porchzombie porchzombie 1 year ago Can't wait to hear the rest of this series... this is some amazing stuff! 3 Reply 1 reply Maria Morris Maria Morris 1 year ago I discovered Dr. Sinclair when Andrew Huberman had him in his podcast, love and appreciate how they are informing us. Thank you, gracias❤ 3 Reply Vadym Kodryan Vadym Kodryan 1 year ago Thank you very much for doing this! Exciting and illuminating! I haven't read the book yet but I am going to. I am indeed confused about how telomere lengthening and hormone replacement therapy fit or don't fit into this information theory of aging. Likewise, some supplements may be hurting in excess amounts and helping in proper amounts (vitamin C and vitamin E). Ultimately, one thought has been troubling me for years: with knowing so much about the human body and understanding so much about genetics scientists cannot give clear-cut recommendations on how to exercise, what to eat and how to organize your life. I have high expectations that this series with bring order to this mess. Reply Julia Julia 1 year ago "A turning point in medical history." This is absolutely fascinating! 7 Reply 1 reply Louise Corrans Louise Corrans 1 year ago I read the book and now am thrilled to listen to this. Thank you for bringing this to us for free! Reply Ahmad Hasan Ahmad Hasan 11 months ago Can't thank you enough for the huge amount of information we get from you Dr. Sinclair. I wish if the video was supported with pics for what was described. 1 Reply Follow that StarGirl! 🌟 Follow that StarGirl! 🌟 1 year ago (edited) Hello Dr. Sinclair and Mr. LaPlante! I manifested you in my life. I am forever 27 and thanks in advance for sharing with me the way. I'm just about to start this episode and I look forward to being in this journey with you! Sending love from Manila ❤ Reply Łukasz Jagodziński Łukasz Jagodziński 1 year ago Great podcast! Not only great subject but it's really fun to watch 🙂. And it's just in time for me 🙂. I'm currently fasting 16/8 for the last 41 days. I just bought MNM and resveratrol. Planning to buy Berberine as the replacement for Metformin. Btw. does Berberine have the same benefits to your health? 1 Reply Adam Carson Adam Carson 4 months ago Dr. Sinclair, based on a comment you made, what's the reason people lived so long before the Biblical flood and started getting shorter lifespans after that? As a side note, THANK YOU!! I've been following your research for several months now and am beyond excited... It's like I'm see another life in front of me literally, and with youth. It's mind-blowing to say the least. 1 Reply avril villodres avril villodres 1 year ago Thank you for sharing your knowledge Dr. Sinclair. I really appreciate what you and Matt are doing. I'm looking forward to your next 7 episodes in this series. I think Matt asks really good questions but the interruptions can get a bit jarring at times. Can you maybe tweak your format a bit so Dr. Sinclair can finish explaining then just do a "going back to what you said earlier" just like Prof. Huberman does in his podcasts? You guys are a treasure! 4 Reply 1 reply Aeon Proelium Aeon Proelium 1 year ago Great podcast. Seen you, David, on Rogan and Andrew's podcasts and been waiting for this to happen. Love it and look forward to more! Thank you 1 Reply Música y Audiolibros Música y Audiolibros 1 year ago This is amazing stuff. Kudos to Dr Sinclair for sharing this with the world! Looking forward to watch the rest of 7 episodes. Reply McNastySlam McNastySlam 1 year ago I’m so stoked you have a podcast! Subscribed. Can’t wait to hear more of your thoughts on this