SIRT6 and Longevity linking longevity with genome and epigenome stability

All-Natural SIRT6 Longevity Supplement Pioneered & Verified By A Prestigious Professor Reverse Aging Revolution 9,902 views May 22, 2023 #Quercetin #Berberine #NMN In this video, Dr Vera Gorbunova, the Professor of Biology at the University of Rochester and a co-director of the Rochester Aging Research Center talks about the important role of SIRT6, the most potent longevity gene in human. How she pioneered and verified the first all-natural SIRT6 activator supplement in the world. How researches shows SIRT6 may contributes to a longer lifespan of centenarian.. According to Dr Gorbunova, compared to Epigenetic Reprogramming, stimulating SIRT6 is potentially a safer way to slow down aging and achieve rejuvenation. Sirtuin 6: https://pubmed.ncbi.nlm.nih.gov/34281... SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species https://pubmed.ncbi.nlm.nih.gov/31002... LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation https://pubmed.ncbi.nlm.nih.gov/30853... Please note that the links below are affiliate links, so we receive a small commission when you purchase a product through the links. Thank you for your support! =*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*= 🧬 DoNotAge Supplements 10% OFF Discount Code : REVERSE https://donotage.org/ref/Reverse/ SIRT6 ACTIVATOR 400mg Caps https://donotage.org/product/sirt6-ac... Pure Berberine 400mg Caps https://donotage.org/product/pure-ber... Pure Fisetin 400mg Caps https://donotage.org/product/pure-fis... Pure Spermidine 8mg Caps https://donotage.org/product/pure-spe... Pure Vitamin D3, K2 & Magnesium https://donotage.org/product/pure-vit... 🌎 ProHealth Longevity 15% OFF Discount Code : REVERSE https://www.prohealth.com/discount/RE... 🔶Restore Our Cells Ability To Make NAD - Nuchido Time+ Supplement ~*~ FIRST ORDER 20% Discount Code: REVERSEAGING20 https://www.nuchido.com/REVERSEAGING 🍀 iHerb New Customer 20% OFF code: NEW20, existed customer 5% off Discount Link https://iherb.co/sUBAZcqw =*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*= Vera Gorbunova is an endowed Professor of Biology at the University of Rochester and a co-director of the Rochester Aging Research Center. Her research is focused on understanding the mechanisms of longevity and genome stability and on the studies of exceptionally long-lived mammals. Dr. Gorbunova earned her B.Sc. degrees at Saint Petersburg State University, Russia, and her Ph.D. at the Weizmann Institute of Science, Israel. Dr. Gorbunova pioneered comparative biology approach to study aging and identified rules that control the evolution of tumor suppressor mechanisms depending on the species lifespan and body mass. Dr. Gorbunova also investigates the role of Sirtuin proteins in maintaining genome stability. More recently the focus of her research has been on the longest-lived rodent species the naked mole rats and the blind mole rat. ___________________________________________ DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes. #SIRT6 #Rejuvenation #SlowAging #SIRT6Activator #epigenetic #DoNotAge #HealthyAging #DavidSinclair #Sirtuins #Epigenetic #Mitochondria #Antioxidant #LookYounger #NMN #Resveratrol #Quercetin #Fisetin #senolytics #OliveOil #Sirtuin #HIIT #Resveratrol #aging #Lifespan #NMN #NR #Spermidine #Metformin #Berberine #ReverseAging #Epigenetic #OleicAcid #NMN #NAD #Fasting #RestoreYouth #Reprogramming #Healthspan #Younger #antiaging #DrSinclair #NAD #longevity #Bioscience #Epigenome #davidsinclair Music SONG First Dream ARTIST Brian Bolger ALBUM First Dream LICENSES Get YouTube Premium Music 39 Comments rongmaw lin Add a comment... Reverse Aging Revolution Pinned by Reverse Aging Revolution Reverse Aging Revolution 16 hours ago (edited) ~*~ All-Natural Product SIRT6 ACTIVATOR ~*~ https://donotage.org/product/sirt6-activator/ref/Reverse/ 🧬DoNotAge Supplements 10% OFF Discount Code : REVERSE https://donotage.org/ref/Reverse/ Pure Vitamin D3, K2 & Magnesium https://donotage.org/product/pure-vitamin-d3-k2-magnesium/ Pure Berberine 400mg Caps https://donotage.org/product/pure-berberine/ Pure Fisetin 400mg Caps https://donotage.org/product/pure-fisetin/ Pure Spermidine 8mg Caps https://donotage.org/product/pure-spermidine/ 3 Reply SungW SungW 13 hours ago Yeah in Korea, we eat various sea weeds called "김" pronounced as "Kim", "미역" "Myh-uk", "다시마" "Ta Shi Mah". As a Korean, I used to be surprised at how quickly are western people aging. And "김치" as "Kimchi" is a super food as well. The truth is that those sea weeds are really delicious. And there is no counterpart from all land plants for the taste. "김" "Kim" is usually used for rolling Sushi. 9 Reply 1 reply Pottenger's Human Pottenger's Human 14 hours ago Very interesting video and these supplements are worth checking out. Fasting also activates sirt6 but of course it's much harder to do a fast than just take a supplement. Some benefits of doing occasional extended fasting: High blood pressure is lowered to normal levels very quickly while fasting. Fibrosis/scarring is reversed over time. Fasting increases nitric oxide release. Fasting restores NAD+ to healthy levels. Vitamin D plasma levels are increased as fasting improves metabolic health, and vitamin D in turn increases autophagy. Stomach acid is reduced over time while fasting and can allow for the healing of treatment resistant ulcers, but some patients may need continued acid reducation medication while fasting. Telomeres are lengthened and fasting also increases anti-aging Yamanaka factors. Fasting stimulates phagocytosis, the ingestion of bacteria, plaques and viruses by the immune system. It will also remove any 'foreign material' that is not supposed to be there. Reflexes and short term memory are increased. Fasts from 36-96 h increase metabolic rate due to norepinephrine release! After 72 hours or more fasted, your body recycles up to 1/3 of all immune bodies, rejuvenating your entire immune system. Fasting can help with MS, Depression, BPD, Autism and seizures. Fasting reduces pain and anxiety by stimulating the endocannabinoid system in a similar way to CBD oil. Thymus is regenerated, which suppresses aging and renews the immune system. The thymus also plays a vital role in fighting cancer. Weight loss from daily caloric restriction has 1/4 to 1/3 of the weight lost as lean tissue while many studies show fat loss from 36 h fasts without losing any lean tissue! The hunger hormone ghrelin also lowers with extended fasting and rises from dieting. Blood sugar and insulin are lowered, allowing white blood cells to move more freely throughout the body and do their job. Some viruses activate glycolosis (the release of sugar in the body) and clinically it has been shown that decreasing glucose metabolism in the body weakens the influenza virus. When you move out of MTOR your body shuts down the building blocks of the cell which are used to produce organelles and proteins. This means the mechanisms needed by viruses to replicate are by and large unavailable when you are in a deeply fasted state. What breaks a fast? Anything with protein or carbohydrates in it will break a fast. Most teas and herbs are OK. Most supplements and meds will either break ketosis directly or contain a filler that will. Many meds are dangerous to take while fasting. Does fasting lower testosterone? No, it raises it when the fast is broken by increasing lutenizing hormone. Fasting also increases insulin sensitivity, which helps with muscle building. Fasts of 36-96 will not affect short term female fertility or affect menstrual cycle. They also may increase long term fertility, especially in women with PCOS. The hormone Leptin is an immunomodulator that keeps the body from attacking itself and obesity causes leptin resistance. Fasting very quickly reduces leptin resistance and leptin levels and one day of fasting can cut your leptin levels in half and gets your immune system working properly again! Does the body preferentially prefer glucose as a fuel? No, except for brief periods of very intense exercise, your body mainly burns fats in the form of free fatty acids. Your brain also prefers to burn ketones at a rate of around 2.5 to 1 when they are available in equal quantity to glucose. Fasting stimulates the AMPK complex and activates autophagy. Autophagy (literally self eating) will cause cells to recycle foreign matter such as viruses and kill cancerous and senescent cells Lowering insulin via fasting virtually eliminates chronic inflammation in the body. It increases mitochondrial function and repairs mitichondrial DNA, leading to improved ATP production and oxygen efficiency and thereby making cells better able to fight off infection. Increased mitochondrial function also has the added benefit of increasing your metabolism and cancer prevention! Fasting also releases BDNF and NGF in the blood which stimulates new nerve and brain cell growth. This can help a great deal with diseases like MS, peripheral neuropathy and Alzheimers. In fact, the biochemical regulator of BDNF production is beta-hydroxybutyrate, which is the same ketone the body produces to nourish the brain while fasting. Fasting also increases telomere length, negating some of the effects of aging at a cellular level. When you fast, this stimulates apoptosis in senescent or genetically damaged cells, destroying them. Senescent cells are responsible for many of the effects of aging and are a root cause of the development of cancer. A fasting mimicking diet for 3-5 days in a row also provides many of the same benefits as water fasting. FMD usually has 200-800 calories, under 18 g of protein and extremely low carbs. Exogenous ketones can aid with fasting, making it easier in healthy people and allowing some people with specific issues to fast in spite of them without worrying as much about hypoglycemia. Children, pregnant or nursing women should not fast for periods longer than 16 hours. People with pancreatic tumors or certain forms of hypoglycemia generally cannot fast at all. Type 1 diabetics can also fast but it is more complicated and should be approached with caution as it could lead to ketoacidosis. Those with Addison's disease may also be unable to fast without liberal use of exogenous ketones, depending on severity. If you experience extreme symptoms of some kind, especially dizziness then simply break the fast and seek advice. Resources: https://www.ncbi.nlm.nih.gov/gene/25712 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093158/ https://n.neurology.org/content/88/16_Supplement/P3.090 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470960/ https://www.ncbi.nlm.nih.gov/pubmed/10859646 https://pubmed.ncbi.nlm.nih.gov/21410865/ https://pubmed.ncbi.nlm.nih.gov/28235195/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413655/ https://www.nia.nih.gov/news/research-intermittent-fasting-shows-health-benefits https://medicalxpress.com/news/2022-10-treatment-pulmonary-fibrosis-focus-telomeres.html https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407435/ https://pubmed.ncbi.nlm.nih.gov/7714088/ https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2019.33.1_supplement.819.10 https://www.biorxiv.org/node/93305.full https://www.ncbi.nlm.nih.gov/pubmed/10232622 https://pubmed.ncbi.nlm.nih.gov/23408502/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752/ https://www.collective-evolution.com/2017/05/16/study-shows-how-fasting-for-3-days-can-regenerate-your-entire-immune-system/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815756/ https://www.ncbi.nlm.nih.gov/pubmed/23876457 https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30605-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1097276518306051%3Fshowall%3Dtrue https://www.clinicaltrials.gov/ct2/show/NCT04375657 http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00224-7 https://repository.upenn.edu/cgi/viewcontent.cgi?article=1537&context=edissertations https://pubmed.ncbi.nlm.nih.gov/31877297/ https://pubmed.ncbi.nlm.nih.gov/23707514/ https://www.ncbi.nlm.nih.gov/pubmed/24905167 https://academic.oup.com/ajcn/article/81/1/69/4607679 https://pubmed.ncbi.nlm.nih.gov/25909219/ https://www.nejm.org/doi/full/10.1056/NEJMoa012908 https://pubmed.ncbi.nlm.nih.gov/15522942/ https://europepmc.org/article/MED/22402737?javascript_support=no https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2265.2005.02288.x https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017674/ https://www.sciencedirect.com/science/article/pii/S1931312809002832 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895342/ https://pubmed.ncbi.nlm.nih.gov/31890243/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526871/ https://www.cell.com/cell/fulltext/S0092-8674(19)30849-9 https://www.ncbi.nlm.nih.gov/pubmed/25686106 https://www.arcjournals.org/pdfs/ijrsb/v3-i11/7.pdf https://www.amjmedsci.org/article/S0002-9629%2815%2900027-0/fulltext https://pubmed.ncbi.nlm.nih.gov/20921964/ https://clinical.diabetesjournals.org/content/36/3/217 https://pubmed.ncbi.nlm.nih.gov/27569118/ https://pubmed.ncbi.nlm.nih.gov/6859089/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779438/ https://pubmed.ncbi.nlm.nih.gov/2518860/ https://pubmed.ncbi.nlm.nih.gov/29727683/ https://www.nejm.org/doi/full/10.1056/NEJMc2001176 https://www.health.harvard.edu/heart-health/abundance-of-fructose-not-good-for-the-liver-heart https://pubmed.ncbi.nlm.nih.gov/20102774/ http://www.sciencedirect.com/science/article/pii/S0005272806000223 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141719/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607739/ This list compiled over years of research by the user known as Pottenger's Human on youtube but feel free to copy and paste this anywhere you like, no accreditation needed! My channel which will always contain an updated version of this list of fasting benefits on the community tab. I also have playlists on fasting and health topics. 21 Reply 6 replies General B General B 12 hours ago Seeweed is also high in Omega3/6. It would be nice if there was a way to boost both Sirt6 and Omega levels at the same time. Typically liquid forms of supplements boost Omega levels. 3 Reply 1 reply JC Yumei JC Yumei 15 hours ago 👍Just started SIRT6 activator 3 weeks, I feel more clear mind recently. may be repairing my dna damage?? good to know every batches got tested. thank you for the explanation💖💖 10 Reply 5 replies Coco CGB Coco CGB 6 hours ago Well sounds amazing! But i along with many will have to wait for an affordable price for another 6 activator😊🕊💪 1 Reply 1 reply Anthony Fasanella Anthony Fasanella 8 hours ago OMAD, time restricted feeding, alternate day fasting, cheat day (usually Sunday) REPEAT!!! Reply Michael van der Bent Michael van der Bent 14 hours ago cyanidin just as much a potent activator of sirt 6 and is available at low cost in many berrys. 2 Reply Malcolm Whitehead Malcolm Whitehead 6 hours ago Olive Oil shòuld still be mentioned. Maybe not as good, but a deal cheaper! MW Reply 1 reply Stefan Allard Stefan Allard 15 hours ago Are they really selling a extract from sea weed for 1000 dollar ? ..... 9 Reply 1 reply L P L P 7 hours ago So expensive though Reply Jenica Epp Jenica Epp 10 hours ago Who the hell can afford to buy this product? Have you seen the price of this product? WTF?!🤨 2 Reply 3 replies Jack jhmc Jack jhmc 14 hours ago So eat more seaweed? 5 Reply 1 reply Yann Lang Yann Lang 14 hours ago Blabla, more fine words and nothing concrete, when you have a final solution tell us or stop with your theories 4 Reply 2 replies Alex Chita Alex Chita 15 hours ago (edited) HI FUTURE CENTENARIANAS 😁 Why SIRT6 Contributes To A LONGER LIFESPAN? | Dr Vera Gorbunova Clips Reverse Aging Revolution 51.2K subscribers Subscribe 398 Share 6,982 views Aug 2, 2022 #Quercetin #PQQ #NMN 🍀🍀🍀Dr Vera Gorbunova presents the findings on researches about long lived species and centenarian. What contributes to a longer lifespan behind them in this clip. According to Dr Gorbunova, other than SIRT6, Dr David Sinclair, Dr. Manuel Serrano are working on yamanaka factors, which is another type of epigenetic rejuvenation. Sirtuin 6: linking longevity with genome and epigenome stability https://pubmed.ncbi.nlm.nih.gov/34281... SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species https://pubmed.ncbi.nlm.nih.gov/31002... LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation https://pubmed.ncbi.nlm.nih.gov/30853... Please note that the links below are affiliate links, so we receive a small commission when you purchase a product through the links. Thank you for your support! =*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*= ☑️ DoNotAge Supplements 10% OFF Discount Code : REVERSE https://donotage.org/ref/Reverse/ All-Natural Product SIRT6 ACTIVATOR 400mg Caps https://donotage.org/product/sirt6-ac... 🌎 ProHealth Longevity 15% OFF Discount Code : REVERSE https://www.prohealth.com/discount/RE... 🔶Restore Our Cells Ability To Make NAD - Nuchido Time+ Supplement ~*~ FIRST ORDER 20% Discount Code: REVERSEAGING20 https://www.nuchido.com/REVERSEAGING 🍀 iHerb New Customer 20% OFF code: NEW20, existed customer 5% off Discount Link https://iherb.co/sUBAZcqw =*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*= Vera Gorbunova is an endowed Professor of Biology at the University of Rochester and a co-director of the Rochester Aging Research Center. Her research is focused on understanding the mechanisms of longevity and genome stability and on the studies of exceptionally long-lived mammals. Dr. Gorbunova earned her B.Sc. degrees at Saint Petersburg State University, Russia, and her Ph.D. at the Weizmann Institute of Science, Israel. Dr. Gorbunova pioneered comparative biology approach to study aging and identified rules that control the evolution of tumor suppressor mechanisms depending on the species lifespan and body mass. Dr. Gorbunova also investigates the role of Sirtuin proteins in maintaining genome stability. More recently the focus of her research has been on the longest-lived rodent species the naked mole rats and the blind mole rat. ___________________________________________ DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes. #SIRT6 #longevity #epigenetic #Rejuvenation #HealthyAging #DavidSinclair #Sirtuins #Epigenetic #Mitochondria #ALA #Metformin #PQQ #CoQ10 #Carnitine #Antioxidant #LookYounger #NMN #Resveratrol #Quercetin #Fisetin #senolytics #OliveOil #Sirtuin #HIIT #Resveratrol #aging #Lifespan #NMN #NR #Spermidine #Metformin #Berberine #ReverseAging #Epigenetic #OleicAcid #NMN #NAD #Fasting #Longevity #RestoreYouth #Reprogramming #DavidSinclair #DrSinclairLab #Healthspan #Younger #antiaging #DrSinclair #NAD #longevity #Bioscience #Epigenome #davidsinclair Key moments View all 24 Comments rongmaw lin Add a comment... Reverse Aging Revolution Pinned by Reverse Aging Revolution Reverse Aging Revolution 9 months ago (edited) ☑ DoNotAge Supplements 10% OFF Discount Code : REVERSE https://donotage.org/ref/Reverse/ All-Natural Product SIRT6 ACTIVATOR 400mg Caps https://donotage.org/product/sirt6-activator/ 🌎 ProHealth Longevity 15% OFF Discount Code : REVERSE https://www.prohealth.com/discount/REVERSE 🔶Restore Our Cells Ability To Make NAD - Nuchido Time+ Supplement ~*~ FIRST ORDER 20% Discount Code: REVERSEAGING20 https://www.nuchido.com/REVERSEAGING 1 Reply Susan C. Susan C. 9 months ago I remember Dr. Sinclair said in one of his interview, SIRT6 has more potential than SIRT1 for extend lifespan. 7 Reply 1 reply Gabriella Besso Gabriella Besso 9 months ago I would LOVE to give it a try, but it's too expensive for me 🥺 I wish you could sell the smallest size with like 60 capsules in it...... 1 Reply WM P WM P 8 months ago Important and interesting Reply Abdelilah BENAHMED Abdelilah BENAHMED 9 months ago Olive oil (genuine not fake) activates SIRT-6. 10 Reply 3 replies Raul Macias Raul Macias 9 months ago LOl Love the sock analogy. 3 Reply 1 reply NadyEu BRY NadyEu BRY 1 month ago ❤❤❤ Reply Ticketforlife Ticketforlife 9 months ago a correction, whales are not the longest living animals, that goes to the Icelandic shark that lives up to 500 years, and probably more. Also I think that we need to figure out WHEN to activate sirt6 WHEN to deactivate mTor. In my opinion, the WHEN question that creates a net with all the longevity factors, is important. 3 Reply 2 replies Debasish Borthakur Debasish Borthakur 9 months ago Can CRISPR-CAS9 technology help building muscles in old people?? Reply Jason P Jason P 9 months ago @10:08 what molecule/compound in seaweed is she talking about? 2 Reply 5 replies Bromans Bromans 1 month ago This lady needs to do some cardio Vera Gorbunova at ARDD2022: Mechanisms of longevity and epigenome stability ARDD 4.57K subscribers Subscribe 138 Share 3,895 views Oct 24, 2022 #Longevity #ARDD #ARDD2022 The Aging and Drug Discovery Conference (ARDD) 2022 is pleased to present Vera Gorbunova from The University of Rochester, with the talk Mechanisms of longevity and epigenome stability. Held in Copenhagen at the glorious Ceremonial Hall, this meeting gathers the most prominent figures of the aging and longevity research field, from scientists to clinicians, investors, developers, and everything in between. The fast growth of the conference is evidence of its great quality. In 2022 we had around 400 people on-site, and many others joined through the web.