avid Sinclair’s 2023 UPDATED Supplement Protocol

David Sinclair’s 2023 UPDATED Supplement Protocol | And WHY He Takes It Wellness Messiah with Rimon 315,548 views Aug 10, 2022 If you’ve been following Dr David Sinclair, you know he updates his supplement protocol from time to time. And in each interview, he gives one piece of explanation to what he does. And certain supplements that appear in one interview, he does not mention them in other interviews. Sometimes it’s hard to follow his protocol today. Since, I know Sinclair’s work since 2007, before he went public in 2019. Here, I have collected for you from a variety of sources, including Sinclair’s book, trying to figure out EVERYTHING he takes today and how much from each supplement. And, you’ll find a very spicy comment from Sinclair about resveratrol. ---------------------------------------------------------------------------------------- ✅ Brad Stanfield vs David Sinclair on RESVERATROL • David Sinclair VS Brad Stanfield on R... ✅ David Sinclair's Original RESVERATROL Study: Amazing Discovery & Analysis • David Sinclair Study on Resveratrol: ... ---------------------------------------------------------------------------------------- Becoming a channel member on Patreon & get benefits: Pateron: / wellnessmessiah ---------------------------------------------------------------------------------------- DISCLAIMER & FAIR USE Copyright Disclaimer under section 107 of the Copyright Act 1976, allowance is made for “fair use” for purposes such as criticism, comment, news reporting, teaching, scholarship, education and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use. ---------------------------------------------------------------------------------------- More Longevity Research Videos from Us: ✅ Suppress TOR by avoiding excess protein How to Suppress TOR Pathway Naturally • How to Suppress TOR Pathway Naturally... Protein Impact on Longevity Explained • David Sinclair VS Ron Rosedale on EAT... How Much Protein EXACTLY You Need • How Much PROTEIN Should You Eat to Li... ✅ Integrate anti-aging foods that target longevity pathways. Collagen for Longevity and Young Skin / 9q3rnfpqwp Collagen Deeper Analysis (Soon) ✅ Reduce inflammation by replacing cheap vegetable oils with healthy fats Omega 3 Supplement and Foods • Omega 3 Supplement: A Guide for Longe... ✅ Move or exercise soon after meals to burn off meal's glucose Yet to be released ✅ Cycle stress and cortisol Yet to be released ✅ Activate deep cleaning inside your body by integrating long fasting ✅ Intermittent Fasting: Intermittent Fasting - How it Works? [PODCAST] • #23-Intermittent Fasting - How it Wor... How to Do Intermittent Fasting: Complete Guide [PODCAST] • Video ✅ Improve Your Sleep Quality Guide • The MISSING Piece for Health & Longev... ✅ Increase the intensity of your exercise, but do it intermittently, Cardio HIIT for Longevity • David Sinclair & James O'Keefe: The S... ✅ Take longevity supplements Resveratrol Controversy Explained • David Sinclair VS Brad Stanfield on R... Taking Resveratrol Correctly: • Fact-Checking: Should You Mix RESVERA... ---------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------- The Wellness Messiah podcast is available on Spotify, Apple Podcasts, and Overcast. ---------------------------------------------------------------------------------------- Credits: Scott Buckley Disclaimer & Disclosure: The information in this video and/or at this channel is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge, educational and information from the research and experience of Rimon, who encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. Rimon is not a medical doctor. If there is a contradiction between the advice here to your doctor or local authorities, always go with the doctor and the authorities. Statements made, or solutions suggested in this video and/or at this channel are not intended to diagnose, treat, cure, or prevent any disease. The statements are not contradictory to first following authorities' guidelines of social distancing and hygiene. Key moments View all Transcript Follow along using the transcript. Show transcript Wellness Messiah with Rimon 55K subscribers Videos About 478 Comments rongmaw lin Add a comment... @WellnessMessiah Pinned by Wellness Messiah with Rimon @WellnessMessiah 1 year ago (edited) Since 2007, I've been researching and testing the best longevity supplements. What did I find? You can get my full supplement routine for free when you get this app: https://wellnessmessiah.com/app ✅ RESVERATROL & David Sinclair: Shocking Detail and Big Mistake - episode 1: https://youtu.be/E-BEm3LwoIs 27 Wellness Messiah with Rimon Reply 5 replies @letadeley8724 @letadeley8724 1 month ago Thank you for this summary and clearing up some of the confusion! I follow Dr Sinclair and find it hard to know exactly what he does. I was totally against metformin before following him, but I have learned so much from him and his ongoing longevity studies Reply @awc4t @awc4t 7 months ago Thank you for doing the leg work for the rest of us in putting this together. It is very much appreciated. 66 Reply 1 reply @TriangleDancing @TriangleDancing 1 year ago This is another very informative video. I just recently found your channel and really enjoy the content, especially when you dive into the details of Sinclair's comments and the studies. Since this one is about supplements, have you considered doing some videos on liposomal supplements? A lot of these longevity substances have very poor bioavailability. Using a liposomal delivery system dramatically increases the amount that gets into the bloodstream (almost all of it from what I've heard) and also facilitates entry into the cells where it is needed. I'm in the process of switching to liposomal (or phytosomes, which is very similar and does pretty much the same thing as liposomes) supplements where they are available for the stuff I take. One last thing, Metformin is mentioned in this video, and that is not typically available to people. You've also mentioned Rapamycin on your channel I believe as a longevity molecule. It turns out there are natural mimetics of those substances. On that reasoning I added ashwagandha, EGCG, and ginseng to my stack. See the study below for scientific support: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723685/ 16 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 5 replies @maz.sniperonmicrodose6525 @maz.sniperonmicrodose6525 3 months ago Thanks for the overview. You mentioned coconut yoghurt a couple of times. He states sever times that he is vegan and uses plantbased (coconut) yoghurt. Also I think he said in one of his podcast he takes 5000ui vit d3 a day. 2 Reply @roseward16 @roseward16 6 months ago Read an article awhile ago that man who had calcification of heart valve and was due to have a valve replacement. He started to take higher doses of K2-7 and asked for tests after taking this high dose of K2-7 and his valve showed significant decrease in calcification. He opted out of replacement valve surgery and continued to take Mk2-7 38 Wellness Messiah with Rimon Reply 6 replies @jefftezos @jefftezos 7 months ago Thanks for all your hard work! You're one of the best longevity streamers. 10 Wellness Messiah with Rimon Reply @santiagogold446 @santiagogold446 1 year ago Thanks for organizing these videos and data. It makes things much easier to reference Sinclair 32 Wellness Messiah with Rimon Reply @vanessagregory8835 @vanessagregory8835 7 months ago Thank you for this concise account. I take 1gm NMN daily sub lingually. I have ordered 100 gm resveratrol and Fisetin on line and am in a quandary about dosage. I take Vitamin D 10,000 and Vitamin K2 90 micrograms daily. At 81 I want to stay on track. I read Lifespan and Super Human and have used NMN since 2018. I purchased a NMN Resveratrol mix on line for my son which he takes sublingually. This was because one supplement was easier for him to remember. My GP prescribed Metformin 1gm when I asked to keep my Blood sugar under control and it coincidentally reduces my blood pressure. Give my son 250gm Metformin. Advised him to ask his GP for a script. He has high BP and my father had diabetes so reasonable request. He My GP said he has been taking Metformin for years as preventative health measures. His father too had diabetes. It is a cheap drug and very safe. 9 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 4 replies @miracoli16 @miracoli16 1 year ago (edited) Great video! Thank you!!! After having watched all your videos I'm still insecure about how much resveratrol to take (30-50mg or 500mg or even 1g like Sinclair does??)....Hopefully your forthcoming videos will help finding the right dosage... As far as i know wheatgerms contain much more spermidine than the sources you mentioned. 19 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 3 replies @Sarah-gm8zy @Sarah-gm8zy 1 month ago Just wanted to thank you for putting this video together, it's definitely required a lot of effort on your side. Thank you and thank you! Reply @ClassicalLiberalWarrior @ClassicalLiberalWarrior 9 months ago I just ran across this channel today (Feb. 6, 2023) and it seems pretty good. I'm a fan of Dr. David Sinclair and Dr. Brad Stanfield, and I've attended two high-quality international conferences on longevity. Almost all this stuff is quackery and snake oil, but perhaps Rimon's content is not. 8 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 4 replies @MaxLofi7 @MaxLofi7 10 months ago Very well done sir. I am now a fan after this video. Keep the viewers updated. I want to know if sinclair changes anything. But also, what happens if nmn is removed from the market? What to take if that happens. Would love to hear a video on that 11 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @antonystringfellow5152 @antonystringfellow5152 1 year ago I'm a little surprised David takes so much of so many of these compounds. Most of them are synergistic to the point of actually amplifying the effects of one another. The effects of Metformin and Aspirin, taken together, is more than the sum of each taken alone. The effects of Metformin and Resveratrol, taken together, is more than the sum of each taken alone. Metformin, Aspirin, Resveratrol and Quercetin are all synergistic, with many overlapping effects. I have taken all of these, and in similar doses (but 1 g Metformin per day) but only for 4 weeks, as a purge. I wouldn't want to risk doing this long-term. The only one I take every day is Metformin and that's because it's the only one of these compounds that has been proven to extend human life and has an excellent safety profile. On the other hand, one study on rats showed that Quercetin increased the occurrence of tumours. Starting Monday, I'll be taking the polyphenol, Pterostilbene together with NR as they seem to have a powerful anti-cancer effect when taken together. Pterostibene has 4X the bioavailability of Resveratrol so I'll only be taking 100 mg per day. I'll also be starting with sulforaphane and eating much more broccoli together with mustard seeds (trying looking that one up). When I was taking Resveratrol and Quercetin (my purge) I mixed them together with soya lecithin, on a slice of wholemeal bread. Both the lecithin and the wholemeal bread boost absorption, especially the lecithin, which has a strong affinty with water. I also mixed in 500 mg of VitC which I had in paste form, in capsules. The Vit C and lecithin help to protect the Quercetin, the lecithin in the stomach and the Vit C in the bloodstream, so it has more time in your system before being metabolised. Anyway, thanks for keeping us up to date.... really appreciate your videos! 28 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 16 replies @michaelberman3648 @michaelberman3648 7 months ago I am aware of the resveratrol you are taking which is a water soluble molecule I believe. What do you think about Pteristilbene which appears to look like resveratrol but is more lipid soluble? Would taking both the water soluble & lipid soluble form be more beneficial in your opinion? And does pteristillbene work under the same or similar mechanism as resveratrol? 3 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies @henrikmadsen2176 @henrikmadsen2176 7 months ago Great to watch your summary!! Sinclair is pretty sloppy when he reports on his protocol. Fantastic to have you to sum it up. Great work. Thanks a lot. 8 Wellness Messiah with Rimon Reply @speedseekers @speedseekers 3 weeks ago Hi, thanks for the great info. Do you know the anwers to the following questions? 1. do you have to keep NMN refrigerated 2. how could I take NMN when I travel (refrigeration not possible) 3. how can I see if NMN is still good 4. when I get NMN delivered it is not refrigerated, how can I make sure it is still good 5. is NMN really harmful once it changes due to not being refrigerated? Reply @deb1000001 @deb1000001 8 months ago Just started resveratrol (for 1st time) at night after a meal, with coffee with the 2 tsp of olive oil and coconut milk. Not as bad as thought it might be. (after watching one of Sinclair's videos, ad lib.) Have to wait and see literally, results. Read about coffee as antioxidant. Also have read that it stops vitamin absorption. (Hopefully just slows time of absorption.) 3 Reply 4 replies @kikilynn1167 @kikilynn1167 5 months ago Amazon is banning sales of NMN products in its store because of an FDA letter stating that NMN is not considered a dietary supplement as of November 2023. This is a reversal of FDA's previous decision. Their stated reason is to protect a pharmaceutical drug development application for a patented version of NMN. 4 Reply @christopherellis2663 @christopherellis2663 1 year ago (edited) Have been aware of D3K2 since learning that my mother died from Aortic Stenosis: calcification of the heart. Thank you, margarine. Res and quercetin are in my protocol 15 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 7 replies @drdavid62 @drdavid62 7 months ago David Sinclair is the last person I would listen to for well-informed objective advice on what supplements one should take for longevity. 1 Reply @AT-xl9db @AT-xl9db 1 year ago I would really like to clarify about Quercetin - it’s not safe to take it every day, it can damage healthy celks, and I dont think Sinclair is doing it everyday either….the study that he brings up (and I can look it up) used quercetin in hit-and-run fashion meaning 3 days in a row then 6 weeks break. Because there is no point to keep taking it everyday - once u remove senescent cells. 95 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 54 replies @MsOrangeknickers @MsOrangeknickers 7 months ago Thanks for this great summary! Can you advise if using Berberine instead of Metformin will be effective. If it will be, what dosage? Thank you. 6 Reply @JWV_ @JWV_ 1 year ago Thank you for your honest work! 👍 11 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @DragonRyderNyx @DragonRyderNyx 7 months ago How helpful - thank you so much!! 1 Wellness Messiah with Rimon Reply @jeffreeOH @jeffreeOH 9 months ago I saw a video by Dr. Berg where he stated that you can take 10,000 IU's of vitamin D3 with 100mg of vitamin K2 (MK-7 form only due to it's increased bioavailability) and not be concerned with calcium build up in the arteries, therefor you might be safe doing that. 7 Reply 2 replies @johnnymurray6275 @johnnymurray6275 9 months ago Thank You for the video. It's quite informative! I appreciate it 👍 3 Wellness Messiah with Rimon Reply @tanyamironova5466 @tanyamironova5466 5 months ago Helpful video, thanks! What about the statins he mentioned he've taken? 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @beautylover8138 @beautylover8138 6 months ago Interesting- If I remember correctly, apples have fisetin and quercetin - pretty much the same amount as in most senolytic activators - I guess the old adage is true- an apple a day keeps the doctor away😊 11 Reply @markfischer3626 @markfischer3626 8 months ago I have enough different kinds of supplements to start a health food store. After seeing your presentation on resveratrol I stopped. It appears to me that in high doses used continuously it might be dangerous. I'll stick to red wine and berries. 6 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies @monkeyMusic7 @monkeyMusic7 1 month ago all his info COMPLETELY corroborates what Dr Gabriel Cousens MD has been teaching for at least 1 decade, as far as i know. Thanks for making this info available Reply @arnoldpillay9834 @arnoldpillay9834 1 year ago Thank you Doc... appreciate your advice 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies @birgittadevlin4206 @birgittadevlin4206 11 months ago How about this study concerning A-HgM (Metformin f.ex.) exposure in patients with T2D was associated with reduced risk of MS in patients younger than 45 whereas in patients older than 45, exposure to A-HgM was associated with an increased risk of newly diagnosed MS, particularly in women. Would this then also apply to Berberine? 3 Reply @jaypena5858 @jaypena5858 7 months ago When talking about vitamin K2 supplement dosage it’s important to be more specific on the type. I believe he was talking about MK-7 K2. You also have MK-4 which in most supplements is dosed higher than MK-7. 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @raylangenbach3508 @raylangenbach3508 1 month ago (edited) There was a question a year or so ago about NMN inducing cancer. I have Stage 4 melanoma, so I have put the NMN on hold. Quercitin also has this tendency? Is there moree up to date info on this issue? Thank you! Reply @auriellenazro2516 @auriellenazro2516 1 year ago I do not have a prescription for metformin. So I decided to substitute it with Berberine since it is very effective in reducing blood sugar. I would like your opinion on this…. 12 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 4 replies @stubbler1969 @stubbler1969 1 year ago Hi Rimon, Do you address, or can you address, Berberine as an alternative to Metformin? My doctor is not really up on longevity research, and she refused to prescribe Metformin to me. However, Berberine is touted as a natural alternative to Metformin, with many of the same benefits, plus others. Of course, I purchase Berberine online, so it's more accessible. Thanks in advance, Chris 9 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 4 replies @KirstiCheetahh @KirstiCheetahh 8 months ago Great video! Just one thing: Taking drugs like Metformin is not natural and not healthy, it has side effects. If you do not eat sugar, you do not need Metformin! I do low carb - high fat - medium protein and IF and most days OMAD. Do sports in a fasted state. Take Pterostilbene on my resting days, not when doing sports. 8 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies @markfischer3626 @markfischer3626 6 months ago He did mot mention apigenin to block CD38. He could have added R alphalipoic acid to quercetin to boost NAMPT. TMG good. All three are required to assure the salvage pathway for NAD+. He vould have added NAC when combined with glycine in TMG creates glutathione, the master antioxidant. There's so much more to know. 2 Reply @soyivalu @soyivalu 11 months ago Very good summarize. Thanks! 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @bogse @bogse 6 months ago (edited) 12:50 so we can conclude that he exercises only 1 day in a week. Just adding more exercise days to his week would probably benefit him much more than all those supplements. 5 Reply 1 reply @youtubeok9228 @youtubeok9228 2 months ago Can u pls list out the supplements in an order of giving high results to longevity.. Reply @cfpup @cfpup 1 month ago Thank you. Well done. Reply @BryanDalleStelleOfficial @BryanDalleStelleOfficial 1 year ago I think he updated the way he takes resveretrol. I heard ( I don't remember the interview) he now dissolves resveretrol in olive oil and a little bit of apple cider vinegar. 7 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 4 replies @michellelouise8865 @michellelouise8865 2 months ago Wow, this was so good, thank-you Reply @greenlion6544 @greenlion6544 7 months ago The poor man’s metaformin you can get over the counter (Amazon) as Berberine, which he used to take. IF you’re a weightlifter (you all should be), take it every other day or just on days you take off. 1 Reply @bernhardwalther @bernhardwalther 1 year ago Great video as usual now. Thanks not to take holidays on that this summer 👌👍 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @EarthGen @EarthGen 8 months ago Thanks for summary of information! 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @tomclayton @tomclayton 6 months ago The idea that supplements other than vitamin D are helpful is misguided, compared to intermittent fasting. I think that you are unusually objective, able to change your opinion with new evidence. I like your analyses in general. Reply 1 reply @antcam007 @antcam007 11 months ago He says in an interview that the resveratrol he takes is "the white stuff, not the brown one" . I thought you would like to mention it in your update. 7 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @popelgruner595 @popelgruner595 1 year ago May I add to the Spermidine question that you find HIGH concentrations of it in wheat germ. It is up to three times the concentration of mushrooms. At least that is what the web says. 4 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 3 replies @tonycastani1560 @tonycastani1560 1 year ago (edited) Why does Dr Sinclair still take such large doses of Resveratrol even though in his own studies low doses worked better for longevity? In one of his recent interviews he mentioned that he now takes Resveratrol every other day. 13 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 4 replies @ginacardarella @ginacardarella 8 months ago I enjoying the way you break down the video 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @MarryPopp @MarryPopp 5 months ago Thank You for the video🙏👏👏👏💐💝💐🌈could be very helping if you would had Made a List of That suplements 💪🌍💝 Reply @maxborn7400 @maxborn7400 6 months ago Is Resveratrol still recommended for MS patients, or any other autoimmune condition? I have seen studies that DO NOT recommend Resveratrol for MS patients, as it seems to exacerbate inflammation. Reply 2 replies @DingusCirc @DingusCirc 1 year ago Its not needed to skip Metformin before exercise.... Especially if you are using TRT. 1 Wellness Messiah with Rimon Reply @MrRterra @MrRterra 1 year ago Great video but you forgot to mention that he said that he also takes statins , cause of his family history . I m curious about that cause i have the same issue ! Thank you ! 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 4 replies @user-wr3gy7el2h @user-wr3gy7el2h 5 months ago Thank You for this amazing channel!!! 👍🤗I subscribed Reply @stellacwalker 6 months ago The older you the higher Vit D , when you research or by the vitamin you can read adults(cause vit D is always given to kids from birth) adult Take 10000 to 20000 units. 1 Reply @telugufunnymoji5564 @telugufunnymoji5564 6 months ago Pls tell which supplement gives more percentage of longevity Reply @-Dan-GT @-Dan-GT 6 months ago Dr. Sinclair also mentioned in one interview that he takes a statin. He didn't say which one or the dose. Reply @gloriagolemboski4515 @gloriagolemboski4515 5 months ago Do you have any advice on strontium . I have it but don’t want to use calcium with it as calcium with Prolia shots went to my arteries instead of bones. Caused calcium in aorta. Reply @riteshnayak80 @riteshnayak80 8 months ago (edited) What about Astaxanthin, which is known to be 3000 times more antioxidative than Resveratrol?? What about ayurvedic Shilajit (asphaltum/mineral pitch) ? 8 Reply 1 reply @AndroidSamsung-qz9pl @AndroidSamsung-qz9pl 1 year ago What about replacing Metformin with Chromium Picolinate and Bitter Gourd? 2 Reply @williamlovett619 @williamlovett619 8 months ago Thank you for this 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies @ryandoherty9696 @ryandoherty9696 1 year ago So am I to understand just to be clear that he takes virtually all of these supplements at the same time or around the same time in the morning? I don't hear him or yourself mentioning that he takes anything later on in the afternoon or evening. (I heard him mention some people take NMN at night time). Just curious, is he taking D, K2, Resveratrol, Quercetin, Fisetin, NMN, Spermedine, and Tri methyl glycine all in the morning? Thank you! 2 Reply Wellness Messiah with Rimon · 4 replies @sofiacosta1897 @sofiacosta1897 7 months ago Great video! Reply @palden4579 @palden4579 9 months ago All the Resveratrol I ordered until now was always brown and not white in color like Dr. Sinclair says it should be. Anybody knows a Resveratrol supplement in which actually the powder is white? 3 Reply 4 replies @Travelbythought @Travelbythought 6 months ago David said in another interview he takes 500mg TMG, so you guessed correctly. 1 Reply @garynapolitano1270 @garynapolitano1270 2 months ago GREAT video! Reply @amitloutube @amitloutube 7 months ago (edited) I need to know which multi vitamins(which brands) especially B complex are best without any side effects Reply 2 replies @MohammadAlaliirhabiubidu @MohammadAlaliirhabiubidu 8 months ago how about gene editing the cells so that the gene cells of specific part of the body is harvested, turned into a partial stem cell, then be put back into the body replacing aging cells and de aging the body parts bit by bit like visions ship of theseus. Reply @emceeanders @emceeanders 7 months ago Sinclair said on Huberman lab that he pulses resveratrol, but does not go into detail. 1 Reply @anthonyrude @anthonyrude 7 months ago You left out the most important part... Where does he get his supplements? I think a company was mentioned in a clip but I didn't catch it. Do you have a company name or link? Thanks 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @cesarvillalobos5183 @cesarvillalobos5183 1 year ago Thaaaaaank you because you speak clearly! Reply @JensSpahn-sn9mv @JensSpahn-sn9mv 1 month ago thx for your work Reply @xochitlmorales6217 @xochitlmorales6217 8 months ago thank you for the information, NMN and Resveratol = NAD+? 1 Reply 2 replies @nmc2049 @nmc2049 7 months ago What would be the recipe for a homemade quality coconut yogurt ? Reply @elenirum2020 @elenirum2020 4 months ago I take a grammar of NMN and a gram of TMG. It seems that TMG creates problems to my sleep. Is there any other alternative as a Methyl Donor? Reply 1 reply @akgh2010 @akgh2010 5 months ago Well, you need also Selenium, Magnizium and zinc. Reply @ibnusuud5312 @ibnusuud5312 2 months ago ubiquinol, methyl cobalamine, benfotiamine, and magnesium might be added Reply @pabf2745 @pabf2745 7 months ago Si, revesterol o arándanos (uvas negras, vino tinto) 1 Reply @roqclimber @roqclimber 7 months ago Rimon, thanks for completing my homework for me! Where were you when I was actually in school? Reply @stevenbrown3035 @stevenbrown3035 1 year ago What about rapamycin? Some are saying it is the most effective, but no mention of it here. 4 Reply @edrock4605 @edrock4605 8 months ago (edited) The fact that he is updating them means he doesn't really know. And we are all going to die. 3 Reply @user-jf5uv9ir5k @user-jf5uv9ir5k 2 months ago Good research mate Reply @stellacwalker @stellacwalker 6 months ago K2 - a banana has enough for an adult but people with heart medication are not allowed to eat bananas or as little as sometimes half. I mean people take supplements they have to try themselves what feels good to you. Can’t give a 💯 plan for anybody and everybody Reply @sabreenmow570 @sabreenmow570 10 months ago how do you measure 1 gm of resvertrol or nmn? Reply 3 replies @scottmccal @scottmccal 9 months ago Great video Reply @letadeley8724 @letadeley8724 1 month ago I think Dr Sinclair only takes metformin at night because he only eats one meal per day (dinner) Reply @fvw53 @fvw53 7 months ago I am surprised that Dr Sinclair speaks this month about new protocols including ONLY 0.5g of NMN on Youtube (Business To-day) "Exclusive conversation with geneticist & Harvard Professor David Sinclair" 2 Reply @roblangsworld @roblangsworld 3 months ago In the photo of resveratrol it appears the capsules contain a brown substance?!? Dr Sinclair says if its not white or gray its off and you should throw it out? Thoughts? Reply @mikecar52 @mikecar52 7 months ago I think Sinclair is nuts. I find anything he says should minimally be taken with a grain of salt. 4 Reply 4 replies @markfischer3626 @markfischer3626 7 months ago I try to research everything I try. I'm interested in the biochemistry of the metabolic process. This is what I found out about NMN. It sounds entirely plausible. BTW, the salvage pathway is only one of three pathways for NMN. https://www.youtube.com/watch?v=Em75xD7Ps6s I give this high credibility and will take this advice when I try NMN. BTW Apigenin is the extract essence of the chamomile flower, the same one used to make tea. I'll buy the R-alpha-lipoic acid too. I already take quercetin 500 mg and TMG. IMO resveritrol, spermidine, and Metformin have been discredited. Better to take no resveritrol than a high dose. I think the original research reached its conclusion based on an error. If spermidine works at all a handful of green peas a day should be sufficient. Metformin seems to have no effect on life extension. It has many drawbacks over berberine. I've had to cut back on berberine to 450 mg per day. More drove my ALT and AST well above normal. 2 Reply 1 reply @clreed9690 @clreed9690 1 year ago Thank you! 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @amritrosell8561 @amritrosell8561 7 months ago Only one itty bitty flaw with this video... You assume that what Sinclair is taking is benefical. For instance, there is quite a lot of research emerging showing that Resveratrol does not activate SIRT-1. Reply @anbrugm @anbrugm 6 months ago So where do you get these products? I do one search for either supplement an I get 10 different suppliers and bottles. And the prices makes no sense, 100x pills of 500mg for half the price of 50 pills of 250mg etc. I'm struggeling to sort all the information.... Reply @salimamry @salimamry 7 months ago To be clear Dow he take all the supplements at the same time with yogurt or ever hour. Or ever other day. Reply @salimamry @salimamry 7 months ago Ok the real question does he take it all at once. Like how much suppliment can you take at teh same time?? Reply @HarryJensen-kr4qz @HarryJensen-kr4qz 2 months ago Where does Sinclair get his NMN, since it's banned for sale? (In part, thanks to him?) Reply 1 reply @miracoli16 @miracoli16 1 year ago Today i saw a new video where he says that he recently only takes 500 mg NMN. 7 Reply @AlexLondon @AlexLondon 2 months ago what about the new nmn controversy that it never goes past the blood stream? Has sinclair responded? Reply @roscopeco2000 @roscopeco2000 7 months ago i take resveratrol in a 1g tablet, i am dubious about ordering tablets off amazon but cant see any other good sources. 1 Reply @Taty14002 @Taty14002 1 year ago I don't get why he's such a guru in aging. He looks his age. He looks middle-aged. Nothing wrong with that but he's a millionaire from all his work and he doesn't look younger than his age at all. 6 Reply 6 replies @EricMySelf990 @EricMySelf990 5 months ago So he won't engage in a discourse with other scientists about resveratrol but he'll make spicy comments in interviews. Reply @ianpipe3129 @ianpipe3129 8 months ago Hmmm. When listening to this guy, he comes across as being envious and condescending when Dr Sinclair may adjust the use of what he may be taking. It sounds like jealousy. Isn't testing and adjusting the supplements part of assessing what the right level of dosing and compatability of products to produce the best products? He is experimenting on himself, so why is that a problem? I don't get the reason for the snide comments with the tone of, "....well, he hasn't perfected it yet, has he?". It's work in progress. Reply @johnnyd2383 @johnnyd2383 1 month ago Our Lord Jesus Christ offers everlasting life... none of these supplements and/or drugs offer that. elbowcough 1 Reply @TrojanMan321 @TrojanMan321 1 year ago What cures for aging is he actually working on? 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @williammartin9450 @williammartin9450 2 months ago Sinclair has lost just about all credibility...why would you be promoting his supplement stack? But then I just noticed that you're calling yourself the Wellness Messiah 🤦🏻‍♂️ Reply @MrBrianDuga @MrBrianDuga 1 year ago Does anyone know what brands Dr Sinclair uses? He doesn't seem to disclose that in interviews. Reply 3 replies @taylanulukr9081 @taylanulukr9081 9 months ago I thought he is also taking alpha Lipoic acid? Did he stop taking it? 2 Reply @ilovelifelifelovesme773 @ilovelifelifelovesme773 2 months ago (edited) so when 50% of people have paracits in the body, do these parasites also live longer and become stronger with these suppliments Reply @eraalta449 @eraalta449 6 months ago I am trying to buy NMN but cannot decide which brand. Should I buy from Hello 100 or Prohealth? Reply 1 reply @ancaromanov5520 @ancaromanov5520 9 months ago Has anyone tried liposomale NAD+ , (have found softgels mit TMG directly in them ) ? Reply @danwall9301 @danwall9301 3 months ago Ask Sinvlair why he is working with thd FDA to get MNM classifed as a pharmaceutical avsilanle to the public only by prescription. Reply @mariabeckwith3336 @mariabeckwith3336 7 months ago I heard Sinclair say he takes Resvetrol every other day. Reply @user-oq3ov9yu6v @user-oq3ov9yu6v 7 months ago Thanks for summarizing, but as for vitamin D, you shouln't take it in the evening, youl'll have problem getting to sleep. 2 Reply @abdinajibisaak2186 @abdinajibisaak2186 8 months ago What are the supplements that will I take every day please I need the least? Reply @aaradhikachopra @aaradhikachopra 7 months ago Anybody know how many months to take without a break..? And how many days in a week..? Reply @peterpau283 @peterpau283 8 months ago Do you know Vitamin K2 and Vitamin D3 are fat soluble. So if you do not have a good Liver and Gallbladder. You can not properly breakdown and hence cannot absorb these vitamins properly meaning you do not know how much of Your daily intakes 1 Reply @robinelliott5561 @robinelliott5561 4 months ago So, is resveratrol good or not?? Reply @bondjane007 @bondjane007 9 months ago What is best to help memory loss of things U R taking Dr. Sinclair? Reply @tomrobertson3236 @tomrobertson3236 7 months ago Resvertol made Sinclair millions Yet the pharma gave up after 2 years So no Resvertol for me Reply @samanthazone7128 @samanthazone7128 8 months ago 13:11 for summary thanks again 4 Reply @cheetahbrfc9016 @cheetahbrfc9016 1 year ago Do you think you can take berberine at night instead of metformin? Whay dose would you take if yes? 3 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 5 replies @VVIP_Prestige @VVIP_Prestige 7 months ago On this video which uploaded on March 28th , he Said he take 0.5 g of NMN https://www.youtube.com/watch?v=fsUUgTPtwnc&t=1349s I am wonder which one he is taking coz I m taking T Niagen, and I heard powder form of supplement are better Reply @peterpau283 @peterpau283 8 months ago Is NMN just a derivative of Vitamin B3 1 Reply @Mishmish210 @Mishmish210 8 months ago What if you exercise every other day? Reply @casino-hi2zx @casino-hi2zx 1 month ago He said he fasts but then he eats yogurt in the morning, can someone explain Reply @the_kingd0m @the_kingd0m 7 days ago David talked about DHEA somewhere and I cannot find it. He spoke negatively of it for some reason, it may have been on the J.Rogan podcast Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @theanalyst5602 @theanalyst5602 11 months ago What company is owned by dr sanclair that produces NMN? Reply @thehunter6170 @thehunter6170 8 months ago How many people can afford to be taking all these supplements? 1 Reply @KThalman @KThalman 1 month ago For 30% of the population has a problem methylating. Those folks should benefit from TMG. Reply @Am3gari @Am3gari 6 months ago It looks like everything that have positive effects in lifespan, has a negative effect in excercise Reply @fluffgirl1000 @fluffgirl1000 7 months ago Were are those suplement hiding…can we buy them Reply @gavinmurray4505 @gavinmurray4505 6 months ago Guys, I live in Ireland,where can I get metphormin in Europe please? Reply @belizeolt4611 @belizeolt4611 5 months ago Who the hell has the time to take 100 different supplements?? And it takes years to even know if something even benefits you. Reply @minyukova @minyukova 6 months ago which brand has 1000 nmn capsules? i can't find anything online. Reply @CarmenRodriguez-ze2xg @CarmenRodriguez-ze2xg 4 weeks ago You know why Spain is going to take Japan as the country with the oldest people in the world?, because the olive oil and the wine It's part of our culture. But we eat a lot of fish, vegetables, legumes, nuts and fresh food. Reply @jenadamsuk @jenadamsuk 1 month ago Don’t forget the basics too… Reply @annethomas4112 @annethomas4112 1 year ago I'm vegan and was wondering if iI still need b12 as I'm taken nmn and tmg 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @peter12266 @peter12266 10 months ago The spermidine levels mentioned would be from raw not cooked so cooked would be substantially less. Reply @janaskopec6033 @janaskopec6033 2 months ago Can TMG help people who don't MTFHR gene mutation? Reply @thehungergames8918 @thehungergames8918 5 months ago 🧙‍♂️💪💪☺️ 1 Reply @sonson5jadamshuzu111 @sonson5jadamshuzu111 6 months ago Cool video Reply @enlightlife @enlightlife 4 months ago statins for anti-aging !? Again… statins will damage the liver and have long been found to create more damage than benefits But hey… when the diet is not very healthy, these compounds will give a helping hand Reply @rrfitnesslv949 @rrfitnesslv949 9 months ago Why not just to eat foods rich in those compounds? 🤨 Reply @dagoelius @dagoelius 8 months ago (edited) "Metformin enhances and mimics the benefits of fasting"..so why not just do fasting. 35 Reply 10 replies @49tumano @49tumano 4 months ago Your criticism sound like you hate this guy. If you don't like him, move on, don't fallow him. Be happy with what you like and le it be . Reply @harriet46wtross7hf9 @harriet46wtross7hf9 5 months ago Can people just live on food? Healthy organic natural food??? Reply @zibtihaj3213 @zibtihaj3213 4 months ago what us the best Resveratrol supplement for longevity ? pls help loll Reply @neilslade @neilslade 1 month ago (edited) Sinclair says no dairy, but then takes yogurt. ??? Coconut yogurt? Reply @gregl2249 @gregl2249 10 months ago I wonder why he doesn't take astaxanathin? 2 Reply @josephcollins6033 @josephcollins6033 3 months ago What do Sarceno ...what ? do to our bodies? Is that cancer? thanks! Reply @jenxsj3902 @jenxsj3902 6 months ago Resveratrol seems to cause more harm than good. I have been taking this for years. What a waste of time and money. 1 Reply @lipstick318 @lipstick318 8 months ago What about NAD +??? Reply @ginacardarella @ginacardarella 8 months ago NMN is sooo expensive Reply @pinkiepinkster8395 @pinkiepinkster8395 2 months ago Bryan Johnson will give you his supplements list for free on the Blueprint diet. Reply @allinthefamilyrecipes4523 @allinthefamilyrecipes4523 3 months ago Are these supplements just for men? Reply @monokumannius4522 @monokumannius4522 5 months ago Sinclair looks older than healthy people around his age. Why would you want to mimic his longevity habit? Hmmm 1 Reply @a1expresstransportllc956 @a1expresstransportllc956 4 months ago Wtf bro which of this supplements i need to take.. Reply @enkibumbu @enkibumbu 7 months ago He takes one gram of M & M's? Reply @markferris3674 @markferris3674 8 months ago What do think about L CARNOSINE ? Reply @lookup9078 @lookup9078 7 months ago (edited) Ja, this man I find interesting but not satisfied, we spoon fed Dave’s protocol. Why? BC he wants you to purc 0:00 if you've been following Dr David 0:01 Sinclair you know that the update is 0:03 supplement protocol from time to time 0:05 and in each interview it gives another 0:07 piece of his protocol and certain 0:09 supplements that appear in one interview 0:11 he does not mention them in other 0:13 interviews sometimes it's hard to follow 0:15 his protocol today what he's doing today 0:17 that's what we want to know now since I 0:20 know Dr David Sinclair Works since 2007 0:22 since I read many studies that he 0:24 published even before he went public in 0:26 2019 here I have collected for you from 0:29 a variety of sources including 0:30 Sinclair's book trying to figure out 0:32 everything it takes today in our March 0:35 from each supplement and in this video 0:37 I'm also going to include a very spicy 0:39 comment from Dr Sinclair about 0:40 Resveratrol so if you take the 0:42 supplements you really want to see this 0:43 now let's start 0:46 welcome to the wellness Messiah podcast 0:49 I'm your host Ramon 0:51 [Applause] 0:51 [Music] 0:58 vitamin d and vitamin K2 I would like to 1:01 start with these because Dr David 1:02 Sinclair stopped mentioning these 1:04 supplements in the latest interviews in 1:07 his book he said I take a daily dose of 1:10 vitamin D vitamin K2 but in 2021 he 1:14 mentioned that he's still taking all the 1:16 supplements that he mentioned in the 1:17 book let's hear it from him 1:21 what are you currently taking uh Doses 1:24 and such like 1:26 yeah well actually it hasn't changed 1:27 since I wrote uh lifespan 18 months ago 1:30 so page 304 1:32 see the list 1:33 now if you do consider to take these 1:35 supplements you wonder why does Dr David 1:37 Sinclair take these vitamin d and 1:40 vitamin K2 supplements in this segment 1:42 it explains why so you can make up your 1:44 mind about your health 1:46 I take vitamin D vitamin K2 K2 is a 1:50 really important one which keeps the 1:51 calcium out of your arteries and puts it 1:53 into your bones where it's needed so 1:54 even though Dr David Sinclair doesn't 1:56 mention vitamin D and K in every 1:58 interview it gives I guess because they 2:00 are more nutritional choice of 2:01 supplements than longevity supplements 2:03 on which is mostly asked about the 2:06 reasons he gave are solid and it's safe 2:08 to assume that it still takes them what 2:10 about the dose of those two supplements 2:12 I never found one interview where he 2:14 mentioned specific doses of those two 2:15 supplements a standard dose of vitamin D 2:17 is between 2000 to 5000 units and a 2:20 standard dose of vitamin K2 is somewhere 2:23 between 50 to 120 micrograms so I 2:26 estimate that his does fall within this 2:28 range the verdict he still takes vitamin 2:31 D in K2 and the dose is unknown let's 2:33 move to the next one this is his most 2:35 famous supplement Resveratrol 2:38 foreign 2:41 so let's go back in 2019 book he 2:44 mentioned I take one gram of any man 2:46 every morning along with one gram of 2:48 Resveratrol shaken into my homemade 2:51 yogurt does he still take the same dose 2:53 in 2022 in his very long interview in 2:55 his channel he confirmed I'm quoting 2:57 I've been taking one gram of Resveratrol 3:00 since 2004. so it's the same exact dose 3:03 the one he wrote in his book confirmed 3:05 of course if you follow Sinclair it's 3:07 not just how much respiratory takes but 3:09 also how now that has been evolved over 3:12 the years so I showed you in the book 3:13 that he mentioned in 2019 that he mixes 3:16 Resveratrol with yogurt about a year ago 3:19 we changed that protocol and then began 3:21 to mix Resveratrol with olive oil 3:23 however I was pretty surprised to see 3:25 that he also changed that protocol as 3:27 well let's hear from him what he is 3:28 doing now 3:31 um I've even tried I like to mix up my 3:33 diet like anybody else I've tried olive 3:35 oil plus a bit of vinegar and a Basil 3:37 Leaf in the morning it's like drinking 3:38 uh we call it salad dressing in the 3:41 morning uh that one lasted for about a 3:44 month I've given up on that I now like 3:46 this coconut yogurt that you've turned 3:48 me onto actually 3:50 the verdict one gram of Resveratrol 3:53 mixed in coconut yogurt in the morning 3:55 as a segue here if you have doubts about 3:58 adding Resveratrol into your supplement 4:00 routine don't go anywhere we're going to 4:02 attach this Resveratrol controversy 4:04 today the next two supplements are from 4:06 the same group the same family of 4:08 Resveratrol the polyphenols the 4:10 flamenols 4:11 [Applause] 4:12 foreign 4:17 explaining why he takes these 4:19 supplements 4:23 um so I've added 4:25 um 4:26 quercetin which is a molecule related to 4:29 Resveratrol which is also 4:32 suppresses the activity of senescent 4:35 cells the the one that I'm testing out 4:37 is physician f i s e t i n n because in 4:41 we showed in 2003 and 2005 in two nature 4:44 papers that it extends the lifespan of 4:46 animals small animals worms and flies 4:49 but nevertheless it's been now shown 4:51 that it's analytic it kills off the 4:53 senescent cells in the body at least in 4:55 mice probably in humans based on some 4:58 human data and so I'm looking at that 5:01 so this is the why but how much does it 5:03 take this segment is from a long video 5:05 in his channel 5:09 visadin and Kirsten half a gram in the 5:11 yogurt 5:12 the verdict 500 milligrams of quercetine 5:16 in phisidine every morning mixed into 5:18 yogurt probably now we can assume it's a 5:20 coconut yogurt 5:21 [Applause] 5:22 [Music] 5:26 the next supplement in our list is an MN 5:28 let's hear Dr David Sinclair explains 5:30 about this supplement and how much he 5:32 takes and so nmn is is what I take each 5:35 day I take a gram of it I know a gram is 5:39 likely to be raising 180 levels during 5:41 day 5:42 I also try to time it with my natural 5:44 circadian rhythm so NAD will go up 5:46 during the morning getting ready 5:48 um 5:50 but if I take it at night 5:53 what I find is that I'm actually 5:55 starting to interfere with my sleep 5:58 patterns in all the interviews he has 6:00 done since then it's still the same dose 6:02 one gram of any man in the morning and 6:05 it doesn't need to be mixed into 6:06 anything just with water so the verdict 6:08 one gram in the morning with water let's 6:11 move to the new supplement in Dr David 6:13 Sinclair protocol 6:14 [Applause] 6:16 spermidine 6:19 let's hear what he says about that 6:24 uh spermity there is you can buy it now 6:26 it's um there's a company that makes it 6:29 in pure form very low levels of gluten 6:31 and just the last few months I've added 6:32 that to my protocol and we'll have to 6:34 see how my numbers look on inside 6:35 tracker okay so that's not that's not 6:38 something you've adopted and you're like 6:39 I'm definitely sticking with it this is 6:41 I'm adopted and I'm testing it out to 6:43 see how it works I am and I actually I 6:46 advise that company it's the first 6:47 supplement company I am advising and I 6:49 did that because I wanted to look at the 6:51 human clinical trials and they they look 6:52 really promising as well how much of 6:54 that are you taking a gram as well okay 6:57 so from this interview it sounds like 6:58 this is the most recent experimental 7:00 supplement in the stack now what about 7:03 the dose this is important to listen to 7:05 this even though in this video Dr David 7:07 Sinclair mentioned it takes one gram of 7:09 pyrimidine later in the comment section 7:12 he corrected this dose he said 7:14 correction I said I take one gram of 7:16 spermidine but the active ingredient in 7:18 the capsules is one to two milligrams I 7:20 apologize for the confusion so the 7:22 verdict about spermidine is one to two 7:24 milligrams taking every day in the 7:26 morning this is what he said also in 7:28 this podcast now if you too consider to 7:30 take spermidine and you think okay this 7:32 is only an experiment he's doing on his 7:34 body maybe if there is a safer and 7:36 cheaper way to guess permittent and many 7:38 of my subscribers ask me how to guess 7:40 permitting from food this study measured 7:42 how much permadine in each type of food 7:44 and and ranks them from the highest 7:45 concentration to the lowest I'm quoting 7:47 from this study spermuding concentration 7:49 in Foods was as follows mushroom the 7:51 highest 7:52 88.6 milligrams per kilo of food green 7:56 peas 65 milligrams per kilo of food and 7:59 broccoli 32 milligrams per kilo of food 8:02 so as you can see there is a bunch of 8:04 spermidine in mushrooms but also in 8:06 broccoli and green peas these levels 8:09 coming from food more than satisfy or at 8:12 least similar to the levels of 8:13 spermidine that Dr Sinclair takes in a 8:15 supplement form and also there is 8:17 another certainty about the safety of 8:19 spermidine in those Foods 8:20 [Applause] 8:21 [Music] 8:25 now we are getting more into the 8:27 controversial stuff let's hear Dr David 8:29 Sinclair explain on why he used to take 8:31 TMG the reason that I take 8:33 um 8:34 glycine actually specifically 8:36 trimethylglycine is is actually to 8:39 counter what I think might be going on 8:41 with an NAD booster but the thing with 8:44 nicotinide mononucleotide nmn is that it 8:47 it has this nicotinamide group on it it 8:50 hangs off the the main part of the 8:52 chemical and it's the first bond to 8:53 break and so we see in animals and even 8:56 in humans that 8:57 the levels of nicotin might go up quite 8:59 rapidly after taking nmn or NR and two 9:03 two high levels of nicotinamide are not 9:06 good in part because 9:09 the nicotinamide gets excreted through 9:12 the kidneys and it's done so that 9:15 happens because it becomes methylated 9:17 into methyl nicotinamide but the concern 9:19 that's that's been talked about in 9:22 social media especially is is this drain 9:25 of methyl nicotinamide a problem the 9:27 methyl groups are are needed for the 9:29 body we need methyl for a whole range of 9:31 things including antioxidants 9:34 and so as a precaution I take 9:36 trimethylglycine so that I continue to 9:39 give my body a source of methyl groups 9:41 now I don't know if that's true people 9:44 ask me all the time 9:46 and take as a precaution because I know 9:48 that trimethylglycine is not going to 9:49 hurt me glycine is good 9:51 and the other thing is methyl glycine is 9:54 also known as betaine uh which on human 9:57 cells is very good for them including 10:00 protecting them against stress so I 10:02 don't see any downside it's not an 10:04 expensive molecule and the upside is 10:07 that I'm preventing my body from being 10:08 drained of methyl groups but the reason 10:10 that I can't say for sure that it's 10:12 necessary 10:14 actually is that our bodies can make 10:16 methyl groups there's a whole pathway in 10:18 fact I did a PhD on it when I was in 10:19 Australia 30 years ago 10:22 um but so I did take it as a precaution 10:24 now Dr David Sinclair didn't mention TMG 10:27 in his last interviews as he stopped 10:29 taking TMG your guess is as good as mine 10:32 but as we can see how he adds and Stack 10:35 Up supplements the likelihood that it 10:38 doesn't stop taking them unless there is 10:40 a very good reason or risk of taking 10:42 them and TMG is a pretty safe supplement 10:44 how much does it take he never said but 10:47 the standard dose is about 500 10:48 milligrams the verdict about TMG is 10:51 yours based on what he said you can make 10:53 up your own mind if you want to add this 10:55 supplement to your supplement routine 10:57 [Applause] 10:57 [Music] 11:01 the next one is metformin metformin is a 11:04 drug of course not a food supplement but 11:06 Sinclair mentioned that in his book why 11:09 does it take Metformin let's hear him 11:10 explaining exactly that I try to take a 11:13 couple of Metformin pills for two 11:16 reasons one is that my family has a 11:18 history of diabetes and metforminism 11:20 very effective at treating diabetes and 11:22 even preventing it so I do that for 11:24 disease reasons but also because the 11:27 work of many Labs has pointed to 11:30 um not just animals but tens of 11:32 thousands of people in clinical trials 11:33 benefiting from that drug which seems to 11:37 enhance and mimic the benefits of 11:39 fasting now what about the dose so we 11:42 said in the book it was one Graham he 11:44 said it takes one gram of Metformin 11:46 every day apparently it changed a bit 11:48 with those in a recent podcast he said 11:51 I'm quoting I take 800 milligrams at 11:53 night but the edit that it does not take 11:55 me to form in the days before exercise 11:58 anyhow 800 milligrams in one gram is 12:01 very close dose so it hasn't changed 12:03 dramatically about the time in 12:04 government forming Dr David Sinclair 12:06 says that he takes it at night this 12:09 corroborates what I found with with my 12:11 own body in my own experiment with 12:12 metformin over the last three years I 12:14 found that metformin is very useful to 12:16 my body before bedtime because it 12:19 offsets the glucose stimulating hormones 12:21 at night melatonin and growth hormone 12:24 these two are natural hormones produced 12:27 by the body and they are increasing the 12:28 Sleep Quality they are good hormones for 12:31 anti-aging however one of the things 12:33 they are doing is increasing glucose at 12:35 night so personally I found what Dr 12:37 Sinclair I guess found himself that 12:39 metformin helps to reduce the blood 12:41 sugar at night but again it's a drug 12:43 it's not a food supplement and it's just 12:46 my experience and not a recommendation 12:47 to anybody the verdict about metformin 12:50 800 milligrams six days a week day off 12:53 the night before exercise another drug 12:55 that Dr David Sinclair mentioned in his 12:57 book in other interviews is baby aspirin 12:59 to reduce inflammation 13:01 now let's go to a summary of Dr David 13:03 Sinclair supplement stack or supplement 13:05 protocol and after that I'm going to 13:07 show you a very spicy comment from Dr 13:08 David Sinclair about Resveratrol 13:10 controversy 13:11 [Applause] 13:11 [Music] 13:17 finishing today's video with resveratrol 13:20 again you may have heard about 13:21 controversies about Resveratrol for 13:24 example these studies show that 13:25 Resveratrol offset the beneficial 13:27 effects of exercise in humans that lead 13:30 us to a very interesting story Dr Brandt 13:33 Stanfield published a video called why I 13:35 stopped taking Resveratrol mentioning 13:37 those exercise studies on his Twitter 13:39 account Dr David Sinclair commented on 13:42 Stanfield video describing it as what 13:44 would seem as horse so this is a 13:47 bit confusing if you're taking 13:48 Resveratrol on its face value there is 13:51 no reason not to go with Sinclair take 13:53 on Resveratrol but what is even more 13:55 confusing is that those studies and 13:58 papers Dr stenfield mentioned seem legit 14:00 luckily there is a video that clears 14:03 that confusion between Dr stainfield and 14:05 Dr David Sinclair I'm going to put a 14:07 link to this video where we clarify this 14:09 confusion so you can make up a decision 14:12 for your own body about Resveratrol in 14:14 your supplement stack in other 14:16 interesting thing about Resveratrol and 14:17 controversy about that is that did you 14:19 know that in Dr David Sinclair own study 14:22 low Resveratrol worked better for 14:24 longevity than high Resveratrol when I 14:27 saw that I was pretty shocked so I 14:29 created another video that explored this 14:31 study and the best Resveratrol of those 14:33 for longevity not necessarily sickness 14:35 for this video as well you can find the 14:37 link in the description so you can find 14:39 the link of both of these researchable 14:41 controversies in the description and the 14:43 pinned comment of this video 14:45 until the next video stay healthy stay 14:47 young and stay subscribed foreign 14:50 [Music]