The David Sinclair $720,000,000 Train Wreck! Dr Brad Stanfield

The David Sinclair $720,000,000 Train Wreck! Dr Brad Stanfield 238K subscribers Join Subscribe 11K Share Download Thanks Clip 274K views 2 months ago 1 product This is the story of how Harvard professor David Sinclair's mistakes earned him $720 million, and is using the same strategy to do it again, today. For weekly health research summaries and extra sights, sign up here 👉 https://drstanfield.com/pages/sign-up … Dr Brad Stanfield tagged products below. Learn more MicroVitamin: A Low-Dose MultiVitamin & Mineral $49.00 Achieve your recommended daily intakes of vitamins & minerals without mega-dosing. Blended with Hyaluronic Acid for glowing skin, and TMG for exercise performance. With over 75% of Americans taking dietary supplements, multivitamins have become a staple in our daily routines. But have you ever stopped to question whether your multivitamin is truly giving your body what it needs? Introducing MicroVitamin: A Thoughtfully Crafted Low-Dose Multivitamin. Most multivitamins on the market today contain excessively high doses of vitamins and minerals, which may lead to potential side effects and wasted resources. MicroVitamin is different. We’ve carefully crafted our formula based on scientific research to help you reach the optimal recommended daily intakes of essential nutrients (both vitamins and minerals) while promoting a balanced diet and healthy lifestyle. A Balanced Diet Comes First: MicroVitamin is designed to complement a healthy diet, not replace it. We believe that obtaining nutrients from a variety of whole foods is crucial for optimal health. MicroVitamin aims to fill the gaps and support your nutritional needs when your diet falls short, ensuring you maintain a well-rounded and balanced approach to your health. The MicroVitamin Difference: ️ Embrace Moderation: MicroVitamin is meticulously designed to deliver the perfect balance of vitamins, minerals, Trimethylglycine (TMG), and hyaluronic acid. This careful formulation avoids overloading your body and eliminates the risks associated with excessive supplementation. ️ Achieve Glowing Skin: Our unique blend includes hyaluronic acid 200mg, a powerful ingredient known to promote skin health and hydration, giving you a radiant complexion from the inside out. ️ Enhanced Performance: MicroVitamin doesn't just provide improved cognition through balanced nutrition, it also includes 750mg of Trimethylglycine (TMG). This compound has been shown to boost strength, power, and endurance when coupled with exercise. Additionally, TMG serves as a methyl-donor and helps lower homocysteine levels, providing an added health advantage. ️ Trust in Quality: Our commitment to excellence means that MicroVitamin is made with only the highest quality ingredients, rigorously tested for purity and potency, so you can have complete confidence in the product you’re using, which means peace of mind for you and your loved ones. Quality Assurance We’ve partnered with a USA supplement manufacturer called ‘Makers Nutrition’ to produce MicroVitamin. Their facilities are GMP audited and FDA registered, so you can be assured that MicroVitamin is meticulously produced and thoroughly tested for quality. SHOP Dr Brad Stanfield 1,651 Comments Add a comment... Pinned by Dr Brad Stanfield @DrBradStanfield 2 months ago What do you think about the statement from the former Dean of Harvard Medical School at the end of the video? Roadmap - how to look young & feel strong: https://drstanfield.com/pages/roadmap 163 Reply 38 replies @lordjim3109 2 months ago David Sinclair is by far the worst disappointment in the longevity community. He started as a great hope for so many, and ended up as the embodiment of all that is wrong with modern science: greed and corruption. 1.3K Reply 48 replies @Vincent-fv1ch 2 months ago This video needs to go viral! 267 Reply @UsDiYoNa 2 months ago Harvard has really become a joke. 241 Reply 8 replies @bornholm1588 2 months ago In Germany we also have a that time famous doctor who wrote books about "forever young" with great success in which he claimed he could expand lifespan with lifestyle and nutrition. Now he is almost 80, still alive, but looks just like all 80 year olds I know. 78 Reply 5 replies @mikecain6947 2 months ago You are very brave to do this video. Thank you and keep them coming. 219 Reply @AncestralFuel 2 months ago Finally someone has exposed this fraud. I have heard of bits and pieces of the Sinclair con over the years, but this is the first time I have seen it all tied-up in a single report. Great job Dr Brad! 326 Reply 8 replies @danpictish5457 2 months ago Just being from Harvard shouldn't mean anything without evidence! 62 Reply @reuterss306 2 months ago More people need to hear this. To me its mind-boggling how many people are still chugging down absurd amounts of overprized resveratrol. Didn't help that many people praised the studies and talked about it so much on podcasts. Like Dr. Rhonda Patrick on JRE. 50 Reply 2 replies @wpmitra7251 2 months ago Any time I see Sinclair associated with any supplement or treatment, I immediately stop paying attention to it. I wonder why Harvard doesn't severe ties with him already. Kudos to you 629 Reply 30 replies @abc_cba 2 months ago This man will be an international level threat to David Sinclair, calling him out, the only one who dares who do that! 513 Reply 18 replies @jamgamber0 2 months ago No surprise why David Sinclair didn't want to debate with Dr Brad in the past. Great work Dr Brad. Cannot thank you enough. Couldn't stop laughing at each comment debunking Sinclair. 57 Reply @SrNutritivo 2 months ago This breaks my heart. I loved his book and literally re-started my life, took me out of a severe depression, and transformed my life in a positive ways. I totally bought his messianic vision about our future. Hurts so bad that looks like all that was based on a lie 38 Reply 15 replies @OdysseuesCotton 2 months ago (edited) Dr. Standfield, I was being critical of your first video concerning David Sinclair, but in the meantime I feel informed well enough to understand better what Sinclair is actually doing. I apologize to you. This video is great and sheds a light on Sinclaire's misdoings. Thanks a lot for that + greetings from Germany 345 Reply 13 replies @travv88 2 months ago Disturbing. Longevity science is too important to tolerate frauds like this. 625 Reply 15 replies @andrewtaylor9799 2 months ago Thanks for publicizing this. 8 Reply @djlouder 2 months ago (edited) Thank you for staying on top of this subject! I especially appreciate your take on B3. Since watching one of your past vids, I started to take B3. It has helped me immensely! Thanks for all you do! 19 Reply @earx23 2 months ago Thanks for exposing Sinclair's fraud. At some point I thought he was sketchy. All we needed was some solid proof. Thanks for this detailed review. 133 Reply 4 replies @thefinalroman 2 months ago David Sinclair uses a filter in all his livestreams to look younger 154 Reply 11 replies @curtasher9110 2 months ago Thank you for posting this, Brad 8 Reply @micahkaneshiro9267 2 months ago Your channel is a shining light. Thank you for being so conscientious. 2 Reply @Hack3r91 2 months ago I too fell for the NMN hype a year ago, fortunately I kept doing research and dropped it before sinking too much money in supplements. Thank you for being a voice of reason. 68 Reply 10 replies @Chaotic313 2 months ago Dr. Brad, this was such a great video!! I was a Sinclair disciple, drinking the snake oil. The first video I saw that cast doubt on what he was preaching was one of yours a while back. Thank you for your well researched, clearly stated information always. 101 Reply 1 reply @viveviveka2651 2 months ago Thank you for covering this. I fell for Sinclair's NMN recommendations. It is the one supplement that really made me nauseated. So I lost a few days to the nausea, and wasted some money. Shame on Sinclair, and shame on Harvard. Lesson learned. 33 Reply @justusklocke7783 2 months ago I follow you since years and have huge respect for your courage!! Keep up your great work! 4 Reply @mikect05 2 months ago Doctor Stanfield you are L E G E N D 106 Reply 3 replies @ChickenDinner13 2 months ago This is the best video you’ve ever created… Thank you so much for putting all of this together 8 Reply @GodMode-xv6sw 2 months ago Excellent work Brad. We support your noble quest. 6 Reply @grahamw453 2 months ago Wow. Thanks Brad for this quality video. You are truly courageous for doing this. Thanks for getting the word out about Sinclairs history. 15 Reply @nicksutton2964 2 months ago Slippery Sinclair and his Sirtuin 100 Reply 1 reply @C2C. 2 months ago Thank you, Brad for staying on top of this and updating us. I subscribe to your channel for your evidence-based approach. You demonstrated integrity when you initially questioned him a couple of years ago and was met by his insults; and you remained steady and professional. It's not easy to call out someone considered a luminary by many. I applaud your intellectual honesty and courage throughout! 3 Reply @AndrewPawley11 2 months ago Wild! What a story! Thanks for making the video! 5 Reply @jimmybaker4821 2 months ago Amazing video brad. Love when u focus on the facts and science 10 Reply @percocetzh 1 month ago Good stuff on calling stuff like this out!Appreciate you Dr. Stanfield keep up all of your amazing work 3 Reply @LauraPazzaglia 2 months ago Well done, Dr. Brad. I have watched you from the beginning and you have finely crafted and refined your way to communicate key issues, as well as taking a stand and not just talking the talk but walking the walk (with your supplement). I appreciate your sharing your expertise in such a concise fact-base manner . Thanks to your videos I have lowered my Vitamin B complex supplement from one that contains 1000%'s of the daily values to a more reasonable amount. Ciao from Italy, L 2 Reply @gospelofthomas77thpearl22 2 months ago Thanks for your honesty. Much appreciated 2 Reply @andymilkowski7682 2 months ago Thank you for this thorough review. 10 Reply @BCIQW 2 months ago Thank you for making this video! 2 Reply @camer0nwiz 2 months ago Thank you so much Brad for making this video!! Reply @richardgabbrielli3328 2 months ago Great video Brad, thanks for sharing this info as many are still not aware of what Sinclair's doing 8 Reply @tracyau9122 2 months ago Wow. I wondered when someone would comprehensively put it all together. Thankyou - great piece! 2 Reply @Ronlawhouston 2 months ago I'm not against people online who sell products. I am, however, immediately skeptical of their motives. 44 Reply 2 replies @thegreaterconundrum 2 months ago This video is so important! What gives misinformation such power is that scientists and thinkers choose to say nothing about it, wether because they think it's obvious or because they assume people already know. But I love that you're calling him out, and I'd love more videos going into bad research practice and calling out specific papers/individuals for this kind of shady misconduct. No one else is going to do it, and if no one does it it'll just get worse and worse! 3 Reply @maxentropy0305 2 months ago Thank you for bringing this up! The truth (or scandal) needs to be exposed more. 5 Reply @0effort 2 months ago what a pleasure to watch a video backed up by facts and cross-references. well done Brad! 13 Reply @bigbear7567 2 months ago Thank you for informing us. 21 Reply @kellicardaras2805 2 months ago Excellent and important video! Thank you! 1 Reply @sexykey 2 months ago Thank you for the video! 2 Reply @miltonmartins8217 2 months ago very informative!! great video!!! 6 Reply @always.wondering.wandering 2 months ago Wow! Thanks so much for sharing this. 5 Reply @JohnSmith-mr1wg 1 month ago Outstanding investigative work. Thanks, Dr. Brad! Reply @karldean2 2 months ago Thank you for keeping it real. You are my go-to doctor for health advice. 1 Reply @carma23 2 months ago (edited) I don’t know if NMN activates sirtuin 1 or not, but there’s no doubt it’s helping me with my chronic fatigue. I would strongly recommend that you don’t paint things black and white 12 Reply 1 reply @patriciastark7292 2 months ago Thank you for your courageous post! 2 Reply @wusnheilus 2 months ago Thank you @DrBradStanfield! Such information is rare on YT. 5 Reply @ankaerjavec9616 1 month ago Thank you for making this video! Reply @jamiesaari 2 months ago You have soooo much courage and are appreciated more than you know. Thank you Reply @loum.4377 2 months ago Thank you for taking this on and calling out bs! 6 Reply @Proximo. 2 months ago Absolutely excellent video. 3 Reply @gstlynx 2 months ago (edited) Thanks , great timeline presentation. 1 Reply @LjudmilaLevy-ml8dh 2 weeks ago Thank you for your research, Dr Brad; people need to hear this information. Reply @Mom_Luvs_Tech 2 months ago Thank you so much for this. 5 Reply @helge666 2 months ago Personally, I've been getting a Snakeoil vibe from Sinclair for years. Didn't even finish reading his "Lifespan" book, because something feels off with it, too. Can't even put my finger on it. I've talked to others about it, but nobody seems to agree with me. However, I trust my own BS detector, and it's buzzing when I see the good Professor talk. 75 Reply 8 replies @patriciaort9172 2 months ago Thanks for this update. Reply @gryphonschnitzel7140 1 month ago Thanks for your videos and effort, you truly are doing humanity a great service by doing what you do. S tier youtube channel. Reply @brendant3979 2 months ago Great informaion, thank you 17 Reply @LidiYaFilms 2 months ago thank you for your great work 7 Reply @byarnneil1916 2 months ago (edited) Great job on your research, people need to know. Much Respect. 1 Reply @tdeprins 1 month ago I have been following you for a couple years and I got deep respect for your courage, your overall style and approach. You balance your videos that include some promotions in a way that is appropriate, staying true to science. Respect! Reply @cktam5670 2 months ago thank you Dr. Standfield. 5 Reply @sverkermansson1744 2 months ago Thanks for your research 7 Reply @chefty88 2 months ago Love your content Dr. Brad, keep up the good fight and don’t be deterred by the machine. Stay independent and realistic. 1 Reply @SharonPitman 2 months ago (edited) I applaud you for putting yourself out there Without people like you, we are none the wiser. After I came across your videos a while ago, I immediately stopped taking many of the hyped longevity supplements and saved myself a lot of money. I love simplicity, I love common sense and your videos just resonated with me. Thank you, again, Brad. You are making a real difference by creating some clarity to such complex topics and oftentimes ambiguous data. You’re awesome 1 Reply @JohnyRelax 2 months ago Thanks, Brad, I used to follow Sinclair, you saved me. 13 Reply @rockhard9690 2 months ago thank you for informing us 5 Reply @johnely5050 2 months ago Thank you for a very informative video Brad. Reply @Kaimelar8 2 months ago Thanks for making a video about this, I think it's important. Reply @ericoshea9382 2 months ago Outstanding analysis and extremely well-timed! Hopefully it will inform consumers as they consider “longevity” supplements such as NMN. 7 Reply @Will-no6te 2 months ago (edited) WOW, great exposé! Thank you so much for your ongoing committment to truth in a world oversaturated with mis/disinformation. 55 Reply @rolandsaucier1006 2 months ago This is the kind of video that makes me happy that I am a subscriber. Well done. Reply @yuliyasalanenka2364 2 months ago Perfect analysis, thank you! Reply @metamind095 2 months ago This needs to be brought more to the public attention. Sinclair should not get away with this level of fraud and deception! 8 Reply @Mikolas649 2 months ago New respect for Dr. Brad, for bringing all the facts, and cutting the BS! 3 Reply @Tron-Jockey 2 months ago Outstanding. Thank you Dr. Stanfield. Reply @ajsindri2 2 months ago I love your channel so much! Thank you Reply @hitmusicworldwide 2 months ago All of these glaring issues could and should have been brought up by GSK scientists before the deal was made. Let's not leave out the incompetence on the GSK side. 720 million is a lot to put on the table without rigorous scrutiny. 33 Reply 3 replies @alfredhammerer3902 2 months ago Great research and on point ! I had done my own little research on this guy and came to the exact same conclusions. Bravo also for the courage to stand up against this guy ! 4 Reply @kickchaw 1 month ago Very interesting! Thank you for your journalism. Reply @adamscottv 2 months ago Dr. Brad keeping it real. You're doing good work. Reply @buck8055 2 months ago Thank you Brad for having the guts to make this video. Hopefully, Sinclair and company won’t use some of their ill gotten gains to try and take you down. Keep up the good fight! 3 Reply @dcope88 2 months ago Great video Dr. Brad. I've always gotten bad vibes when I've seen Sinclair. I am glad to know that my instincts were correct. 11 Reply @zainulasri6753 2 months ago Thank you for sharing this . Reply @JosePerez-pn3ke 2 months ago Thanks for ur steadfast commitment to protect ur audience!! 1 Reply @missgrace1946 2 months ago (edited) Many of us have known for years that David is one of the most incompetent and unethical people in the longevity space. He really should be arrested and charged for what he has done to companies and their innocent investors, and for placing so many lives at risk. 93 Reply 3 replies @davidbelanger2717 2 months ago Thank you 4 Reply @patc1764 2 months ago Thank you for getting this important info out .. Reply @jonathanantoine4962 2 months ago Thank you for your courage and ethic 1 Reply @bobkristiansen2704 2 months ago I don't trust any longevity researcher who undergoes cosmetic surgeries. It's so easy to go back and see David Sinclair gradually lose facial movement. He looks like a doll. 213 Reply 9 replies @Laura-gx9jr 2 months ago Excellent exposé! 4 Reply @blackgoldeneye 2 months ago Now I’m even more grateful for your channel. 1 Reply @mestrinimaster3602 2 months ago Thanks for covering this issue, backed up by facts! Commenting for the algorithm 1 Reply @jfp17 2 months ago “The issue is Sinclairs’s incompetence/genius.” It’s a fine line between the two. 16 Reply 2 replies @BaneTrogdor 2 months ago As soon as i saw him, something about him screamed FRAUD! 7 Reply @brendafosmire6519 1 month ago (edited) Thank you!!!! Much needed telling of this ‘story’. Those researchers who rush science to their own profit so often get later shown to have over simplified their finding. And the pharmaceutical profit hunters don’t care about outcomes, they only care about what will sell. THANK YOU! Your summary is excellent with detailed flow of events with references. Reply @deel2435 2 months ago Don't let the haters get you down Dr Brad! Keep up the great work. Reply @user-kz5ch3gr2b 2 months ago In regards to NMN I just turned 60, Ive been on it for about year...NO QUESTION it works I hope they don't get rid of it as I can see and feel the result of taking it. 6 Reply 2 replies @ccdub15 2 months ago I followed Sinclair years back, but i had my reservations about him when he shared that he was a vegan and ate only one meal a day, which woukd leave anyone malnourished. 21 Reply 4 replies @ChrisPikeEnterprise 2 months ago Thank you for clearly explaining the situation about Sinclair. You are a treasure Dr. Brad! 1 Reply @user-qx5sb2xs9d 2 months ago Thank you, DR Brad! Reply @GHFrankie 2 months ago Thank you for putting the word out! I tried Sinclair's nmn and resveratrol regiment after all that hype in podcasts a few years ago, and it felt pretty obvious to me in the first few days that this can't be good for the human body. This is not just a case of making bank from useless supplements, people can get seriously hurt by what Sinclair's peddling. 7 Reply @LAMPSSSSSSSSSSSS 2 months ago Thank you, Mr. Stanfield! 8 Reply @MAKE_PHOTOGRAPHS_ANYWHERE 2 months ago Thanks man ! I watched this guy and kind of makes my skin crawl. Reply @arl4945 1 month ago Excellent reporting Reply @jamesleadley7872 2 months ago Hard to believe Harvard isn't investigating this and looking to revoke his position. I know it's a long hard process but it's got to start. 34 Reply 1 reply @Physionic 2 months ago What a story - thanks for sharing. 11 Reply Dr Brad Stanfield · 1 reply @UghIHateTheseThings 2 months ago Wowwwww. Amazing. Thank you so much for doing what others are unable to do. You will truly be remembered on the right side of history. Reply @Raokeno 1 month ago Thank you for enlightening me about this topic Reply @russeldeakin8792 2 months ago Great job, I typically complain about your take on nmn and intermittent fasting because I feel like I have benefited from both. I do want to appreciate your strictly scientifically proven approach to health, I hope some of more the anecdotal science can expressed in a more formal way so we can get good advice with a lot less cost and more samples to learn from. Thanks for your take on David Sinclair, he is a real snake. 7 Reply @mac2658 2 months ago (edited) Four years ago Sinclair with his scientific credentials and his father's wonderful story of second youth convinced me to buy alot of nmn, metformin and resveratrol, I took it for a couple of weeks and gave me headaches, I threw it all in the garbage can. Eat well, exercise, manage your social and mental health, that's it. 42 Reply 3 replies @lucashealth 2 months ago Thank you! This changes my perception. Reply @joemoya9743 2 months ago Very well explained. Thank you. Reply @nelsonhoffman5922 2 months ago Absolute legend! 5 Reply @billbimson2408 2 months ago Yep, I got duped by the NMN saga. Spent a lot of money on it. I bought 6 months worth of NMN and TMG (Beltain). It did nothing for me so the 'experts' on Youtube told me that I had too much CD38 and would need to take Apigenin so that the NMN could perform its magic. Bought a months worth of that and there was still no effect from it. When I posted this on Youtube, people started saying I should take it with Oleic acid or other supplements. How many additional supplements are you supposed to take to get this crap to work??? The thing is, there are so many people on Youtube explaining how they have wonderful results from it. Surely they can't all be lying? 10 Reply 3 replies @ml3141 2 months ago This is AMAZING! Thank you so much for this information!!! . Reply @Healthyman-nr8he 1 month ago Thank you for your work. Reply @mystikrebel1089 2 months ago I see this all as positive in long run because by questioning and critquing everything will eventually will help the /de-aging science longevity science to move forward 9 Reply 1 reply @duncan.o-vic 2 months ago Resveratrol is one of many pan-assay interference compounds that are extremely reactive and tend to give false positives by reacting with the fluorescent dye. These typically get a lot of hype for multiple health benefits while in fact being potentially dangerous due to their reactivity. 3 Reply @manojlogulic4234 2 months ago Well, you just got my sub and like for this. Thank you for bringing our attention to this. Reply @PetePH 1 day ago Good to know. Wish there were more videos like this! Reply @danielmccarthyy 2 months ago Although I disagree with Brad on statins, I applaud this excellent video. 5 Reply @BigDaddyBostin 2 months ago David sinclar is hella smart for that and he knew what he was doing 5 Reply @seijirou302 2 months ago Thank you Dr. Stanfield Reply @_al_c2638 2 months ago Thank you for the research Reply @marcjames3487 2 months ago Hopefully all the other influencers will stop giving him space to aggrandize himself. One thing I've learned in business over many decades is never deal with people who lack integrity. I spotted that fatal flaw in David Sinclair from the beginning. Kudos to the academics calling him out. 62 Reply 5 replies @aquamarine99911 2 months ago Thanks for this. I tried resveratrol and NMN back in the day. But fortunately, I also did blood tests every month. When my ALT started to go up to unacceptable levels, I stopped. 3 Reply 2 replies @patmazzucca3926 2 months ago Thank you for this information Reply @palbi 2 months ago Powerful statements! Well done! Reply @sallypilcher6761 2 months ago Looks like Elizabeth Holmes transitioned and is calling herself David Sinclair! 51 Reply 3 replies @serge747b 2 months ago (edited) Harvard is the gift that keep on giving.... 5 Reply @faiek100 2 months ago Thank you for pointing out this conman, great work Reply @CG-zm9oj 2 months ago That was a brilliant presentation 1 Reply @mjs28s 2 months ago What is amazing to me is that with a buyout that large they didn't require them to prove their testing with another test done with the company that was wanting to buy them out. Non-disclosure and the patents would protect Sinclair's scam from being ripped off. 4 Reply 1 reply @brazilchem 2 months ago I take traces of resveratrol by drinking one bottle of red wine on fridays and another one on sundays. 5 Reply @Sobchak2 1 month ago I normally don’t follow this channel, but this is a pretty brave video. Well done. Reply @carlabarber8944 2 months ago You’ve just reminded me to add Sinclair’s book to the bin going to the street tomorrow. Thanks for how you’ve laid this all out for us! Reply 1 reply @philliponfitness 2 months ago holy cow this is WILD can't believe we used to listen to this guy 8 Reply @DavidMM255 2 months ago This comment is for raising the awareness on the information brought by this video 9 Reply @wisefix9256 2 months ago Great video Reply @franb6789 4 weeks ago As a scientist myself, I'm very distressed about the lack of honesty and integrity in many areas of science. Harvard is a cesspool and an embarrassment to the scientific community. We need a national, independent oversight organization who reports to the public on people like Sinclair. Thank you for making this video. 1 Reply @Pixel-junkies 2 months ago (edited) When I saw Matt Kaeberlein resign my thought was 'gosh guys finally'. It took awhile but finally a few people are speaking out who are around him doing similar work. I am glad to see some movement, but at the same time it sure did take awhile. Still part of me just wants to think Sinclair is plain old incompetent because it upsets me more to think someone would intentionally mislead people to this level. Anyhow about time.... 5 Reply 1 reply @dac33nr58 2 months ago (edited) Not surprised, there's a saying even intelligent people can be convinced with enough scientific jargon. 6 Reply @Future_looksbright 2 months ago Thank you so much for posting. This pisses me off. I even made a TikTok video was a clip from the Rogan podcast that I now have to go and delete. I had no idea. I’m so sick of all these scammers you can’t trust anyone these days literally nobody. 2 Reply @jdxx59 2 months ago Thankyou, thankyou, thankyou…it’s so difficult to know who to trust and believe nowadays. I appreciate you alerting us to this. I trust you. Reply @righthomosphere7962 2 months ago Sinclair seems so modest the way he speaks that's how you sell nowadays 23 Reply 2 replies @MrJamesdryable 2 months ago So Resveratrol doesn't extend lifespan? Because I've been taking it for like 3 years because of Sinclair. 3 Reply @Uriakus 2 months ago Muchas gracias. Ya era hora de qué alguien clarificara lo suficiente sobre el tema de Sinclair Reply @sorenostergaard 2 months ago Thank you Brad. This is an absolutely essential video you have made. It is very very problematic that a Harvard professor is essentially driven by money and fame and serious science. But we live in an age where the smart and dishonest people laugh all the way to the bank. 10 Reply @Sjs9000 2 months ago GSK getting hoodwinked for $720 million is pretty funny 103 Reply 9 replies @annroman4561 2 months ago Thank you so much Reply @DM-jt4rh 1 month ago Well done Bradley very good video! Reply @Paul-zs7rd 2 months ago Sinclair comes across as a calm smooth talking psycopath con-artist, because that's exactly what he is. 19 Reply 3 replies @haldx 2 months ago Good job Dr. Brad. 4 Reply @samplastik13 2 months ago Good job keep it up Reply @thomasowens5824 2 months ago Good on you Brad. 1 Reply @nitrostudy9049 2 months ago Excellent. Thank you. I am so sick of the expansion of Machiavellian Scientists in Academia. 7 Reply @ariedrevel5111 2 months ago Okay, back to eating Kale and sauerkraut.i 6 Reply 1 reply @jcgmba98 2 months ago “Walls of incompetence “….outstanding! Reply @Number1TravelGuru 2 months ago Thank you very much for this video. It has been needed for far too long. Too many people have placed blind faith in this charlatan. His bona fides come from the fact that he is a tenured Harvard professor. I haven't heard a direct attack on Dr. Sinclair's work previously, certainly not from anybody with credibility like yours. I appreciate the work you do! Reply @jamesoommen 2 months ago May be a PR job by GSK. Am I to believe that all the other products (vaccines and drugs) by this company went through the same risk/ benefit analysis? 4 Reply 1 reply @martinzubero9526 2 months ago How about that…a pharmaceutical company got bamboozled? Good job Sinclair 4 Reply @jordanj.5681 2 months ago His adams apple moves so much when he talks. And now you can’t unsee it. 2 Reply @robsherwood5065 2 months ago I have spent thousands of dollars based on sinclair's recommendations. Doctor Brad.I truly appreciate you exposing this. 1 Reply @wrongusername 2 months ago (edited) Question. Why don't we use the fluorescent dye that was identified to extend lifespan? 3 Reply 4 replies @ConstanzeC 2 months ago There is no shame in being wrong in science, it means gaining knowledge. But it is a shame not to respond to critical questions like yours and to simply dismiss them as "horse shit"! The fact that people accuse you of falling for Sinclair when the whole world has fallen for him means nothing but a lack of overview. 14 Reply @nathanvandendungen4450 2 months ago Crazy, read Sinclair’s book but clearly didn’t know anything about him. Thanks for sharing. Reply @vickiwithers8563 2 months ago Outstanding Thank you Reply @janosszocs148 2 months ago (edited) I'm 50 years old, I have 32 years of intense activity in the gym. Resveratrol and NMN is working for me. I have more energy, more power, much leaner body, and I'm definitely healthier. The internet is full of prophets. So you have to test it if you want, if is good for you keep it. It's simple. 14 Reply @Just4AZ1 2 months ago What makes Sinclair believable is he tends to come off as a very humble guy. His low, monotone voice also gives credence to his "matter of fact" statements. 7 Reply 2 replies @BandilungTz 2 months ago Thank you! really appreciate! nearly bought the NMN Reply @123axel123 2 months ago Great video. I like confrontation. It forces advancement. Unless Sinclair responds, I trust Stanfield. 1 Reply @alexg9790 2 months ago This is great - the swindling drug company gets swindled and GSK cries foul. Drug companies along with poor academic incentives destroyed peer review systems and integrity. If we had a healthy peer review system GSK would have had enough info to make the right choice. GSK champion peer reviews moving forward. 3 Reply @joshydillens148 2 months ago Happy I never read Sinclaires book I ordered years ago - Straight to the bin! 5 Reply 1 reply @RyanJDavis 1 month ago Bravo Brad! Reply @DeathCoreBrii 1 month ago I'm so glad I found this channel, I was almost on the Sinclair hook. When it sounds too good to be true, it probably is! 1 Reply @LionelsHeart 2 months ago People generally are what they look like 5 Reply 1 reply @Vgallo 2 months ago Your totally wrong about nmn and nad boosters, I’m chronically sick and nr gives me the energy to get out of bed everyday. So you gotta stop talking shit about nmn and nr 3 Reply @lorimckay2704 2 months ago wow Thank you! You are hero in my eyes! Reply @DeepEmoticPhoria9 2 months ago I'm commenting this only to upvote your video to YouTube, so more people can see it ;). Thank you for this. Reply @jodihammer 2 months ago Wow. Legal fraud. Why are we just hearing about this now! Thank you Brad for posting. 3 Reply @Ronlawhouston 2 months ago I did some background research on this mess. You need to be careful with how you are portraying the facts. GSK bought an already publicly trading company for a premium. At the time they paid $720 million, the stock was trading at $12 per share but GSK paid $25 per share. Sinclair was only a part of the founding of that company. According to publicly available documents his take was about eight million. I agree that Sinclair is more a publicist than a scientist. We also don't know if he is truly incompetent or a fraud. What's important is to state facts without any distortions. Your videos left me with the impression that Sinclair pocketed $720 million. That's just not accurate. There are lots of reasons GSK paid so much for that company. Many of those reasons are factors other than David Sinclair. I really like you and help promote your content. Be careful when criticizing the vain and arrogant. They are snakes and snakes have a habit of striking at threats. 12 Reply 3 replies @zbridgjpxupzm 2 months ago Great to see your Resveratrol David Sinclair expose again, since the previous video was taken down... 1 Reply @bradd5961 2 months ago It's super important to get the word out about this. No doubt he'll keep enough for himself while everyone else is excluded. 2 Reply @Lirakis1 2 months ago Chad Sinclair vs Virgin Scientists 4 Reply @allencrider 2 months ago Stanfield is no better, being a social media 'influencer' and trying to sell supplements to an ignorant audience. 5 Reply 1 reply @vinvenus4581 2 months ago excellent. thanks!!! Reply @Droidzi 2 months ago Thanks, Brad, for an interesting summary on the "situation". All we need now is a critical-event-no-one-saw-coming, and we've got ourselves the next Oscar contender. Reply @nft3 2 months ago Sinclair also bragged after taking the pfizer jabs, saying he's feeling even stronger after them. 4 Reply @jackkrauser1763 2 months ago At this point it has become that you have a sinclair bias 5 Reply @williamlavallee8916 2 months ago Excellent topic and presentation. I tried both Res and NMN realized they didn't work. I assumed it was just for me. Reply @Blazz900 1 month ago Thank you. Reply @MaxLambrecht 2 months ago Very important video! Reply @Oksid007 2 months ago Jealousy is not good for your lifespan. 8 Reply 3 replies @tilmanbiallas2488 1 month ago Very Nice Video Reply @joshrosebrookskincare 2 months ago I used to read and follow Sinclair until I discovered Dr Brad Stanfield. 2 Reply @lionary 2 months ago Thanks! Reply @petermilian4455 2 months ago Love the stubble / less shiny skin look. Impressed with you always finding new ways to up your influencer game (seriously)! Reply 1 reply @christianer7802 1 month ago Very informative. Can you do a deep dive into the NMN world? It's hard to know what or who to believe. 1 Reply @bonanzatime 2 months ago Thank you for putting this together. I've been loosely following the resverotrol controversy from the beginning. Sinclair's biggest problem is people with long memories. 1 Reply 1 reply @Pluvo2for1 2 months ago Good on ya Brad. Reply @Thebusysuperhuman 2 months ago I dont agree with you everything - But thank you for this - I really admire and respect the detail you looked into this and also exposed it all as David has lots of fans. Well Done Dr S Reply @sau002 1 month ago Thank you Reply @holasoyjose9683 1 month ago Shocking....thank you Reply @philodox7599 2 months ago Thank you so much for calling him out. Reply @endresbielefeldt2050 2 months ago You have been saying this for years, i was there when you made your first video and i am grinning at the critics who claimed you only were envyous. Just fantastic if one has the last laugh! Reply @JD-mz1rl 1 month ago I appreciate your zeal for real science -- something far more rare than one would think in our world that is supposedly "driven" by it. Reply @princemishkin1601 2 months ago Well done Dr Brad for exposing this guy! There are way too many of these characters milking the social media world and it's about time we were all more discerning. Reply @machampioninvestments4242 2 months ago Nice work. A lot of us once trusted Sinclair. 1 Reply @anthonywatts7645 2 months ago Thank god there are decent honest people calling this crap out Reply @ronjean6034 2 months ago After watching your post: I was horrified, then felt let down, then angry, then disappointed & now furious for believing D. Sinclair & following his recommendations. I am just thankful you have published this data now. Being quite health conscious I hate the thought that I have been deceived into doing something that may actually endanger my life. Thanks, I will definitely be following your posts from here on. Reply @luigifrancisco3786 2 months ago Wow - you are so brave! Reply @DonkeyFrog 2 months ago Best video ever 1 Reply @David-sq2en 2 months ago I still with Dr Sinclair. His research have helped me a lot. Reply @CartoClips 2 months ago Incompetence / genius! My new favorite phrase! Reply @landonjennings-stoyles9804 2 months ago Well done Reply @ilevitatecs2 2 months ago oh boy. this is going to blow up. 2 Reply @siven283 2 months ago Thanks. Reply @eremiassandbk7403 2 months ago Stunned Reply @LIQU9or 1 month ago Whis is wild! Crazy it isn't blowing up in the news and this video doesn't go viral! Reply @lmj5994 1 month ago Great video thank you. Important to know when key actors are dishonest. Reply @rachelkarengreen99 2 months ago Thanks for this video! I stopped taking resveratrol because of it. Are you saying NMN also does not work for anti-aging? 1 Reply @rayfalciola6163 2 months ago "...Wall of Incompetence..." I think you've stumbled into the paradigm of the future. 2 Reply @dang4546 2 months ago Thank you for this. Very sad on top of all the healthcare scandals that have caused laypeople to distrust our institutions and many scientists. Reply @johnnyjohnny7204 2 months ago thanks for the info and covering this. saw this elsewhere and it makes me burning mad at sinclair. Reply @8803surri 3 weeks ago Wow!!! This is a revelation!! Reply @JohnnyMagorish 2 months ago (edited) Great video. Hopefully this will finally start to erode Sinclair’s still huge fan base 1 Reply @ClowBwas 2 months ago needs more views!! Reply @attepeltonen2661 2 months ago Thank you for putting youself out there publishing this well arqued video calling out Dr. Sinclair. I hope the mainstream media eventually catches more onto this. Seems like you're doing work they have neglected, as Sinclair seemingly have been very visible in many places, where healthspan has been covered. Reply @dzdxdd 2 months ago Thank you for the truth about a corrupt fool. Reply @mathew9851 1 month ago Wow, shocked is an understatement! Reply @clintatk 2 months ago It's a sad state of affairs. I read his book and felt I'd gotten real valuable information on the aging/anti-aging processes. Your revelations and research into the Sinclair issue, as well as your other research reviews, are a real help toward safer more effective supplementations. Reply @SamuelMM_Mitosis 1 month ago Thank you for exposing this, I was someone who trusted David Sinclair because of his strong credentials. It’s very sad to know that even in the best institutions we can’t trust individuals. 1 Reply 4 replies @mrcanisters 2 months ago Good expose Reply @K8tdid 1 month ago So glad you spoke up. David Sinclair has a Duper’s smirk like he put one over on everyone. Where did the money go? Reply @freshcutgrass 2 months ago Thanks to you, I didn't fall for the NMN scam. Thanks for your truthful reporting! Reply @Droidzi 2 months ago If resveratrol causes damage, would those proven harmed consider class action? 2 Reply @amizan8653 1 month ago David Sinclair’s 3 walls of incompetence I love that branding 1 Reply @blackmartini7684 2 months ago What do you think about the cellular reprogramming claims? That Sinclair claims they regrew optic nerves in mice using 3 of the 4 yamanka factors? 2 Reply @higherresolution4490 2 months ago (edited) Top job! Much admiration, gratitude to you. At the time when Sinclair was coming into prominence, I was working in a mitochondrial genetics lab on a University of California campus. None of this made sense to me. I always thought he was a bit of a fraud. GSK took the bait! They should have consulted someone in my position who was working in the field of bioenergetics. 1 Reply @patrickfinnegan5202 2 months ago You would think that David Sinclair would admit his fault and push past it. I guess you have to be careful who you listen to, and not put complete faith in someone based on just what they say, but to actually research on your own in more complete depth. I know that Brad has always done this and I believe he is a man of integrity. One day will think that a molecule extends life and then in the future we discover that through extensive research beyond the original research of that molecule that it’s not what it seems and Brad comes forward with the new information in real time with each molecule that presented. Thank you kindly Brad, you are the best! By the way, how is the rapamycin study progressing? 1 Reply @diamond_s 2 months ago Resveratrol has been shown extending lifespan of fish and some strains of mice. The issue with sirtris is they tried artificial sirtuin activating compounds but they proved toxic and worse than the nonpatentable resveratrol. 1 Reply @pattonlawpractice2194 2 months ago Kudos to you for exposing this fraud. It's troubling that someone can get that far with a scientific claim and no reliable evidence. Reply @jgarma 2 months ago Fine job reviewing a complicated topic, Brad. I once admired Sinclair and have resisted changing that perspective, but the evidence is bruising. One thing to point out is that Sinclair didn't take all $700+ million to the bank, given that the sales proceeds were mostly divided between investors and others; however, his bite was quite a mouthful. 1 Reply @SanderBessels 2 months ago I have a question. What about Sinclairs work on macular degeneration, “resetting” the epigenome by letting cells go a step back in the direction of being a pluripotent stemcell, resetting the Horvath clock and all that… The treatment seemed to work for elderly people with reduced eyesight, right? 1 Reply @larryd6143 2 months ago Ps. Thank you, you did an excellent job exposing Sinclair. I must make a point of watching more of your videos. Reply @nails2me 2 months ago Fascinating commentary Brad! What an unscrupulous person, who through his blatant lies could possibly bring considerable harm to anyone who follows his advice and uses his products. Thank you for this informative video. Reply @Neel_44 2 months ago Preach it doc! Thank you for shining light on this crook 1 Reply @shar7508 2 months ago Dr. Stanfield, is your MicroVitamin pure? Where do the ingredients come from? Third Party tested? Thank you! Reply @jekkleegrace 1 month ago good on you Reply @bringbackthefiretv495 2 months ago (edited) I appreciate this. I had NMN product I loved 3 or 4 years ago and Sinclair got the proprietary rights and people stopped carrying it. I have never liked him Or trusted him since then and would never buy his supplements. So sad huberman had him on. I lost respect when I saw that. So glad it's coming out and thank God he doesn't have a market on some of the valid Longevity supplements that they are available and affordable still. Reply @Cyberbronco 1 month ago Great video! How did you make that thumbnail? Reply @jebbiekanfer8843 2 months ago (edited) Research is always ongoing. There’s a paper out there somewhere to support just about anything and another paper to dispute it. Reply @luigolas 2 months ago It’s been a long way since that answer he gave you on twitter once. Glad you are covering all this. Reply @edgarsnake2857 2 months ago I used to listen to health advice on youtube and take it largely at face value. My bad, I guess. The people I listened to were doctors, professors and generally legit seeming people. So many of the health miracles they touted have been debunked that I barely pay attention now. I still listen to Dr. Stanfield...with a grain of salt. 2 Reply 2 replies @MrChrisJ74 1 month ago I thought you were just someone trying to profiteer from bringing down a popular influencer but to the contrary, this is a very well informed video. Thankyou for raising the alarm. Reply @Dggb2345 2 months ago “Walls of incompetence” humans are quite clever and never to be underestimated as to their cunning. Reply @melkor321 2 months ago (edited) I think Sinclair is a great scientist who has discovered why we age and is working on how to reverse aging with yamanako factors. He deserves credibility for that imo. The resveratrol case may have been a mistake and nmn may still be beneficial in activating repairing genes. If he happens to be wrong it doesn't mean that he had bad intentions. Isn't the guy who called him out at the end of the video the same who bought the resveratrol company? Obviously he's still mad 1 Reply @aseemshrestha3354 1 month ago I dont know about Resveterol but NMN works ! There have been clinical trials outside Sinclair labs..and my experience tells me too... Reply @betel1345 2 months ago Thank you for your investigation! Harvard Uni, do the right thing... Reply @TEKIVAV 1 month ago Yeah, plus you can customize depending upon what you load in Reply @altar1102 1 month ago Brad you da man!!! Be careful out there tho ! 1 Reply @WalayatFamily 1 month ago Sinclair is like a James Bond Villan 1 Reply @eidanchris 1 month ago Harvard is beyond a joke at this point... 2 Reply @keithdow8327 2 months ago $5.00 Thanks! Reply Dr Brad Stanfield · 1 reply @MalikNfkt 2 months ago (edited) I appreciate the facts and details in this video. The ability of Resveratrol and NMN to slow down aging in humans is inconclusive and unproven, but certain Harvard faculty members characterizing them as "snake oil" may be just as extreme as claiming they can reverse aging. 2 Reply @liveloveride1676 2 months ago Amazing Reply @monicabroniecki7624 2 months ago Thank you Brad. Great expose. I shall await Harvard severing all ties with that guy. Hope I’m not living in hope! The reputational damage to an institution like Harvard must be huge. Reply @Brian-oz8io 3 weeks ago From what I understand the dog paper hasn’t been peer reviewed yet and even the guy who resigned from the board said “the results are encouraging.” I’ll reserve judgement until the study goes through the peer review process. If it does actually improve animal cognition and can be replicated, I wouldn’t consider it snake oil. 1 Reply @patrikbatemanx 2 months ago this is fking wild good video 1 Reply @civilapalyan6253 1 month ago Great stuff, thank you for the clarification. I feel that it's simply no use to jump on the latest longevity hype, because it's still unproven, and can be even harmful, and actually reducing your lifespan. Just like with the overdosed resveratrol. 1 Reply @diamond_s 2 months ago Multiple studies have shown life extension on mice. Studies on shorter lived strains and studies using fasting to boost nad+. Failure in some mice is due to age related nad+ decline, resveratrol needs nad+ booster in advanced age to compensate for nad+ decline. Reply @alexandercapablanca3673 2 months ago Thank you for exposing Sinclair's corruption 1 Reply @John-kd1bf 2 months ago So does NMN offer a benefit. Should anyone consider whether to take this supplement? 1 Reply @signupisannoying 1 month ago I read about resveratrol about 10 years ago and after that I always wished to be able to consume it regularly. Luckily, lack of money prevented me. Blessing in disguise. Reply @user-hd4jc1ct8q 2 months ago (edited) Thank you for the excellent investigative reporting. Sinclair is also knowingly incorrect in claiming that NMN is as good by weight or better than NR (nicotinamide riboside, niagen). Reply @dianastoyanova597 2 months ago I’m afraid he’ll come after you legally thank you for exposing this information!! 1 Reply @eileenm9252 1 month ago Is there something you could recommend us those of us do to detox resveretrol from our body? I took his advice and started taking NMN AND resceretrol and I can tell you I definitely suffered from breathing difficulties and stopped taking those supplements after about 6 months. Accupuncture has massively helped and I could say most if not all symptoms have pretty much been wiped out over the past two years but watching this video makes me wary yet again and feel the need to more thoroughly detoxify those from things from my body. Reply 1 reply @mycofairbanks3321 3 weeks ago First time I saw Sinclair on a 1 hour long video. I couldn't even watch to the end before I had a gut feeling that he is not credible. I posted my objection to the data he provided... No response. Thanks for bring this to light. 1 Reply @mko-ai 1 month ago Your skin is looking great Reply @mikelautermilch8939 2 months ago make this go viral, everyone! Reply @jamescarpenter1842 2 months ago Would've never expected this from Dr. Sinclair. So disappointed 1 Reply @kinghenry100 2 months ago Do GSK just do no due diligence before spending a billion dollars of shareholders money? 2 Reply @SlamminGraham 2 months ago (edited) The really sad part about all of this is that we, as individual human beings who care about our health, want those large companies with cash and a can-do attitude to spend those large chunks of money on big aging reversal and anti-aging projects. But when companies get completely defrauded in their purchase of the academic research like this, the motivation for other companies to do the same thing becomes much lower. 1 Reply @KarennaC 1 month ago Alberto Villoldo in his book Grow A New Body ... recommends to take Resveratrol for short period of time, after your body is primed for it with a healthy diet - and not to take ongoing as it does the opposite of its benefits. Reply @HkFinn83 2 months ago Resveratrol, NMN…another magical molecule due in a couple of years, by which time there’ll be a new intake of people interested in longevity who don’t remember. Seen in happen in fitness for decades, where the same supplements come and go every few years for a new audience. Reply @elgaen555 3 weeks ago (edited) David Sinclair has talked so many times publicly about how disappointing resveratrol was in practical application. He admitted the failure and kept doing his work. Investors want no risk and all the reward it seems. You’re literally selling a vitamin. 1 Reply @jillkthomas 2 months ago wild, makes you want to rethink All supplements Reply @msplateaugal 2 months ago I have been taking NMN for five years and have seen numerous benefits. I hope it is not banned as a supplement. Reply @sharonkahan1079 2 months ago (edited) I can’t even hear this- the animal cruelty on mice is intolerable… when did the “human “ race become this selfish and with such lack of empathy?!! Animals are not ours to exploit, they suffer and feel as well! STOP ANIMAL CRUELTY!!! 2 Reply @SkalaRocko 2 months ago I have taken NMN since October. Energy level is way up, sleep better and feel healthy. I work out and try to eat healthy. Do you recommend NMN? Reply @unholyquail4560 2 months ago Good Video Dr. Stanfield. Well documented and evidence based argumentation. Personally did fell for the NMN part but since then moved back to NR (cheaper and more evidence based). Guess my wallet also already know. I will have to say that the Information theory of Aging from Sinclair, though largely a theory based on the Hallmarks of aging, does still contribute valueble information. Guess his theoretical work on the demethylation of the epigenomen is still worth something. Ofcourse because most of the research itself was done by others. I will also do like to state that even though the NMN saga en resveratrol saga.. the Research from Sinclairs lab on the Yamanaka factors is still very promising. Though never looked at the reprodution of the studies (if any) at this point. Reply @carlotulio3411 1 month ago Sinclair leads a team working on various research, some of which are interesting. Just because resvatrol went bad in the long run doesn't mean that everything his team does in the future will be bad Reply @joelapatrick 2 months ago “At the time of recording this video, there’s no clear reproducible benefits of using small doses of poison.” LOL. Great video. 1 Reply @glynemartin 2 months ago Brad looks like the lead singer/keyboardist in Dirty Loops... Reply @MichaelAlberta 2 months ago Shots fired! 1 Reply @modemarcoj8026 2 months ago Good for him to work a pharmaceutical company out of 720 million 2 Reply @Jason.Davis. 2 months ago Look at the big brain on Brad! Honestly, tho - dude looks like he could use some health supplements in the regime. Reply @ellesdes1197 1 month ago I had no idea Reply @chrishowe8614 2 months ago I found this interesting because DS always seemed a bit pie in the sky and full of something other than resveratrol! Reply @salient244 2 months ago Careful brother, American's love the court. Appreciate the honesty though Reply @dawnfmEnthusiast 1 month ago Looking forward to see what Professor Huberman has to say about this. He had Sinclair on the pod. Reply @Protolamna 2 months ago I take low dose NMN because it seems to give me some mental energy which I am sometimes lacking. Have not compared with other versions of B3 that closely but the versions and dosage of NMN I use are not that prohibitively expensive. Reply @Ruthless-Ones 2 months ago "The truth will set you free" Reply 1 reply @DJRAGNAL-oh2sf 3 weeks ago Bro made it clear for us: "no hope, no fear" He trolled everyone and took the money 1 Reply @jojonesjojo8919 2 months ago Ha ha ha. What a genius! Well he had me totally fooled. Nice one Prof Sinclair. 2 Reply @jamiemobilerepairnow5968 2 months ago You have to respect the hustle. Reply @donwinston 2 months ago (edited) Video idea: A review of animal studies using coconut oil to deliberately make animals become overweight and develop atherosclerosis. There are scores of people who think dumping gobs of coconut oil goo in their morning coffee is a healthy thing to do. 2 Reply @guillermosahuquillo4499 1 month ago (edited) Gout sufferer here, and resveratrol always inflamed my joints whenever I (naïvely) took it. And that was before Sinclair’s Lifespan was even published. I thought the theories contained there may work for someone, but not for me. Reply @geneharrogate6911 2 months ago I'm becoming ever more convinced there must be a 'sucker' gene. You either see the hussle, or you don't. 1 Reply @fine_gold 1 month ago His book about SIRT2/nmn reads like a sales pitch Reply @NoNo-ro9gx 2 months ago (edited) If anyone is interested in what works for longevity, here it is. NMN, NR, Glycine, NAC, Cakg, clean diet, proper sleep and exercise. You're welcome, just saved you a bunch of time. 2 Reply 2 replies @inisus 2 months ago I always thought he looked like Homelander, including the evil grin. Reply @chazmiller1444 2 months ago This is abhorrent behavior by an absolutely horrible narcissist who should be nowhere near a prestigious institution such as Harvard or any other for that matter. Something must be done. 1 Reply @DELLRS2012 1 month ago I brought his book and totally fell for it buuuurnnn Reply @jordanedgeley6601 2 months ago Excellent video, i shall buy your snake oil vitamins instead im joking btw its just a bit pricey but the quality and profile is very good Reply @JESS-CH 2 months ago Wild Reply @andynater1885 2 months ago As an Australian I'm very disappointed but not surprised, nice work. Reply @alexkang1788 2 months ago Keep up the good work. We need this type of report to save us from theseacademic cons Reply @nate_rndm 2 months ago I briefly tried taking resveratrol several years ago because of the claims made by Sinclair. Didn't notice any positive effects, and if anything my intuition and interoception were suggesting slight negatives. Never bothered to buy any more, and now after watching this I'm glad I didn't. The case for NAD+ seemed weak from the outset, given the acknowledged tendencies for it to convert into other forms with questionable effects, and it's a relief I never got into that either. Things like sulforaphane and specialized probiotics have been the exact opposite experience. Tried them and noticed significant changes in performance and quality of life, then afterwards found out about research suggesting those benefits were genuine. Reply @yummybeers 1 month ago As the person who is close to this kind of work… it’s another Theranos. It would not have been very hard to find out that he was grifting. 1 Reply @ocoro174 2 months ago damn that's crazy Reply @scottairhart8594 2 months ago What I know is that when I drink red wine my blood sugar drops substantially. Can you explain why that happens? I am asking- diet aside- why that happens. I ask because I don't see a reason to drink wine just so I can have lower blood sugar readings. Thank you. Reply @ClayTallStories 2 months ago Whilst I don't lose too much sleep over giant pharmaceutical companies losing large amounts of money I do very much appreciate the effort and time you Dr Brad have put into creating this important content around our slippery mate David Sinclair. Reply @emveretarcon 2 months ago I also became interested in the longevity space because of Dr. Sinclair. Time is ticking and I hope we stop wasting resources on ineffective treatments going forward. Reply @jedwards1792 2 months ago I hope Sinclair doesn’t try to sue you, Dr Brad. Reply @user-es4fx7wo6r 2 months ago Now i wish you to go after all popular peopels out there. Mb start with bryan johnson next? i try to follow a lot with what his doing/saying. mb you gonna find something that we should not do in his protocol? Love your work <3 much thx Reply @Captain.Fantastic 2 months ago Crazy stuff. The guy is on so many podcasts. How is this even legal? Reply @WillaVlogs-jf6zk 2 months ago People! It's not that hard - follow a Mediterranean diet, drink alcohol in moderation if at all, avoid head trauma, don't smoke or do drugs, prioritize sleep and mental health, and get regular exercise more days than not. It is literally that simple. 1 Reply @MOVIEKICKS 1 month ago Thank you Dr Stanfield! Sounds like Sinclair s/b a pariah in the medical community instead of a Harvard professor. So does NR or NMN do any good to boost longevity? I see LifeExtenions selling NR. Reply @rn5697 2 months ago Can u make some video on Omega-3/ lovaza? Reply @davidhammer7410 1 month ago There was a time when a Harvard degree was seen as a huge accomplishment - it seems like less and less of a flex these days. 1 Reply @BobiB 2 months ago I've noticed Resveratrol in a lot of topical skincare products. This video addresses ingesting the substances, but not topical use. Is it still dangerous to use this topically? Reply @europaeuropa3673 1 month ago (edited) Not the first time a Harvard researcher has pulled this kind of stunt. Reply @subhashchandra3318 2 months ago Sir please increase the quality of Zinc and copper in micro vitamin and make it of bisglycinate form also you can reduce the amount of hyaluronic acid 1 Reply 1 reply @perlovgren55 2 months ago David Sinclair is the Resvera-troll 1 Reply @fidelogos7098 2 months ago What about NMN? I stopped taking resveratrol years ago, but I'm still taking NMN, along with TMG. 1 Reply 1 reply @MrGreatestDancer 2 months ago Hey Brad, the beard is just right, no more, no less. Reply @darcoln3208 2 months ago They can't take away tenure I guess. Does Resveratrol actually bind to the Sir2 protein? Those experiments are relatively easy to do. Reply @simonwiltshire7089 2 months ago We also know that pharma own the journals so nothing published where self interest is involved are not worth reading. 1 Reply @scottk1525 2 months ago I'm surprised no efforts have been made to study the dye that activated the sirtuins. Reply @shaun5916 1 month ago Yep Reply @MichaelAmen316 1 month ago What is the healing protocol for ulcerative colitis? 1 Reply @joonlee7884 2 months ago You have Chromium in your mutivitamin but there are studies showing that chromium supplement could potentially be converted to it's carcinogenic form inside the cells raising cancer concerns. Can you make a video on this? If chromium is worth taking or not? 2 Reply @Cosmic_Empress 2 months ago (edited) If consuming resveratrol is bad for you, is it also bad topically? Several skin care products include it now? Reply @fabiomerlin8820 2 months ago I had a strong sensation that it was all B.S. right from the beginning. Now I know I was right. Thank you for the explanation. Reply @mschannigan8831 1 month ago So then is Resveratrol toxic? My husband has been taking it for years on recommendation of his doctor and now he is beginning to have kidney issues. Is this really the case? I Resveratrol actually toxic or am I misconstruing? Reply @TheRealTommyR 2 months ago As a Harvard student, wow! Reply @cpeagle247 1 month ago When you get evil plus genius, it equals menace to humanity. Reply @coolworl 3 weeks ago There is no one to blame for losing 720 mil because of greed. Who would unquestioningly give that kind of money away without validation? SMH. Reply @berdi4berdi4 2 months ago He's doing the same with NMN. Many fell into this hype. You don't need to spend on this very expensive supplement when there are other cheap generic alternatives like niacin or nicotinamide Reply @meb3369 1 month ago I remember reading Sinclair's book and not being impressed. He talked about a moment where he had a hypothesis he wanted to research, and his advisor told him to "go and prove it" or something to that effect. From the get-go this raises a red flag. The point of science isn't to prove correct your biases and baseless presuppositions. He never really seemed totally grounded in reality in that book. Wish i hadn't wasted my time reading the entire thing. Reply @catman4471 3 weeks ago Shouldn't the FDA be made aware of this in respect to the dispute over the ban of NMN? Reply @jeffreywp 2 months ago Great breakdown, Dr. Stanfield! I heard Dr. G last year in an interview talk about his issues with Sinclair’s research. Glad he took a stand! Big time “Ouch!” for GSK as it sounds like they didn’t do their homework. Reply @stuartist 2 months ago When you’re on the side of big pharma, you’re the baddie 2 Reply @nunyabeezwax6758 2 months ago Well crap I have been using resveratrol for a while now :( But did swap to pterostilbene for the most part... Reply @baconinvader 2 months ago And to think, I got into health because of Sinclair Reply @clap5 2 months ago So does NMN not work? Is it harmful? Reply @chazmiller1444 2 months ago Thank you Brad for continuing to shine a light on this greedy snake oil selling narcissist who unfortunately continue to be welcome on notable podcasts. Hopefully with your continued effort he will eventually be rejected. 1 Reply @MetYsJa 1 month ago So whats the verdict, is it only resveratrol that doesn't work, or all the supplements he recommended? Reply @paulwolf3302 2 months ago Seems criminal. 1 Reply @FlatToRentUK 2 months ago So should we all be taking the fluorescent dye in order to activate SIRT1? Reply @grambebe 13 days ago David Sinclair works to help humanity. Too bad smaller people spend their time trying to discredit him! Reply @b0b0- 2 months ago I knew two people who started referring to red wine as medicine because of this guy. Alcohol is life shortening, clearly. Reply @evelynmelian-glick436 2 months ago Thank you for this video. I’m deeply disappointed in Sinclair. How can we trust anyone in this anti aging field? I find you to be one if the few that has integrity. Please continue to inform us on healthy supplements and lifestyle. I’m currently taking NAC AND GLYCINE without obvious benefits. What’s the latest on these?! Thank you in advance Reply @Icarianbrother 2 months ago Mice have shown that rapamycin increases their longevity by up to 20%. Elegans have shown that rosmarinic acid increases their longevity by up to 18%. Are longevity studies using rosmarinic acid being done on humans or mice? 1 Reply @HSLSFirst 1 month ago Great video shining a light on a crook. 1 Reply @Themata 2 months ago No sympathy for GSK, but man I wish Sinclair now came with a warning label 1 Reply @samhayward5350 2 months ago I don't even know what to think anymore. I really hoped this guy was going to be able to reverse aging soon :( 1 Reply @dfinite4089 2 months ago Grateful to you for revealing all this. Had no idea! Was taking reversatrol and nmn! I bought Sinckaur’s whole shpiel! Why do so many people still have him on as a guest and expert?! 1 Reply @larryd6143 2 months ago It is shocking, but at the same time not all that surprising. He comes across a little too much as a salesman and not a scientist. How can he still be at Harvard. Can he not be fired? 1 Reply @nategreen5560 2 months ago It's like that one Always Sunny episode where Mac had that display board out that said "Science is a Liar Sometimes" Reply @genevievepluviose9919 2 months ago That is why I make choices very carefully. I tried Creatine -- did not work for me -- it could have the quality of what I was taking -- but I don't care, letting it go. The latest 'bandwagon' is Urolithin A. I'm not even considering it. Taking the normal stuff: CoQ10, Omegas, a multi, zinc, C, etc. Reply @thomasgrimm1664 2 months ago Thanks so much for the summary. What a disappointment Sinclair has turned out to be. 1 Reply @ShyAlon 2 months ago Ouch Reply @juno6 1 month ago This shows the immorality of animal testing... taking innocent sentient creatures and torturing them just to get away with a fraud should be totally forbidden. Reply @levi5073 2 months ago (edited) He's a psychopath. That story he tells about watching his mother die, which inspired him to solve ageing and disease. Only a psychopath could use his mother's death to make $$$ 2 Reply @connorjones4775 2 weeks ago This guy is counting on you all not doing a simple google search Reply @FortuneCookieLies 2 months ago If you want to increase your lifespan, make sure that you don't fall in old age. That is the number 1 thing that causes early deaths for old people as they break hips which send you on a downward spiral of health. The only reason to use resveratrol in any way would be to cycle it with once per month and then take a ton of creatine and taurine afterwards. But even then exercise is more important and key. Physical activity is more important and due to resvertatrol reducing the benefits of exercise, it makes no sense to take it. Tissue repair is more important. Reply @kevinscott4938 1 month ago Dr Sinclair is the new Dr Berg..... 1 Reply @black_squall 1 month ago One of his recent interviews with star talk the guy looks like he's actually had work done on his face. Reply @Goodnews99457 2 months ago I'm at loss. Don't know whom to trust anymore. I truly believed Sinclair. Following my grandparent's advice from here on Reply @Marrow9000 1 month ago Anyone else hear Sinclair on podcasts in 2018-2019 and start taking resveratrol for antiaging and heart? He seemed like an honest researcher that was on to something. Reply @uberpekes 1 month ago Does anyone have any insights into if Sinclair's "work" on fasting/time restricted eating is impacted by this? The amount of academic fraud uncovered in the last 12 months has blown my mind. 1 Reply @ruthhorowitz7625 2 months ago Harvard, nuff said! Reply @Cletus_the_Elder 2 months ago Well, it certainly wasn't a train wreck for Mr. Sinclair. He won the lottery. Reply @jacked_asian 2 months ago I realized Scicomm Media (parent company of Huberman Lab and Perform with Andy Galpin) doesn't include David Sinclair's podcast anymore. Reply @brandongraham8833 1 month ago Where can we buy that fluorescent dye? Reply @shardovl586 2 months ago Well, I had a great placebo effect when I was taking it, that's a shame 1 Reply @stlounsbury 4 weeks ago (edited) Thank you for this talk. It’s cruel to do that to the lab mice. Causing them to suffocate by crushing their organs, how horrible. Tiny little horrors in far hidden laboratories; I would rather have the wrinkles than to condone such tortures. Reply @LVArturs 2 months ago (edited) I guess that one publicity photo where Sinclair looks and grimaces like an evil scientist was actually representative. 1 Reply @TheDavidlloydjones 2 months ago At MIT they have a technical term for this effect: "Harvard." Reply @natureins4644 2 months ago So far the biggest Dr Sinclair's accomplishment is getting people to drink more red wine... 1 Reply @cambodianriverpig7613 1 month ago Next you should do Vivek Ramiswamy pump and dump. Reply @_Chev_Chelios 2 months ago “There’s no clear benefit of using small doses of poison” Now that makes sense Dr Brad! Reply @superfne1 1 month ago What's the fluorescent dye?? Methylene blue?? Reply @asdfghjkl1755 2 months ago Are you recording this on iphone sir? Reply @asadchoudhrya 1 month ago Loooool good luck son Reply @nunyabeezwax6758 2 months ago Is he why NMN is banned though? Like holy shit... That is SO HELPFUL TO DYSAUTONOMICS/POTSIES/CFS SUFFERERS IN TANDEM WITH RIBOSE ... Reply @jaro6985 2 months ago Such a good video, shame how much effort was spent studying this that could have gone to another compound. Reply @tomrobertson3236 2 months ago Sinclair led me down the health span rabbit hole Shame on him 1 Reply @kchuen 1 month ago Honestly even when Sinclair was at the peak of his popularity, I could tell he had anti-social personality traits from his interviews. 1 Reply @Karatekjell 2 months ago Resveratrol has many other benefits. I have never taken it for the Sirtuins. Reply @ohanlonj8476 2 months ago We need to get Brad on the Joe Rogan Podcast to talk about this & more! Reply @LencoTB 2 months ago I wish Brad had more focus on supplements that help with stress. Something that affects many people on a daily basis. Rather than so much focus on longevity. Reply @swimbait1 2 months ago (edited) Due diligence: if you are going to pay 750M for a business, do some research. I think the shenanigans Sinclair is pulling with NMN are shameful particularly after he promised to never do something like this. But like him or not, Sinclair lit a fire, a huge fire under the feet of longevity. Look how many channels are now on YouTube based primarily on longevity. Even this channel has benefited enormously from the foundation Sinclair got rolling. Sinclair made longevity exciting and possible for millions. I take NMN and haven’t noticed much but millions of others including my wife claim it has helped them. Reply @vethum 2 months ago I've followed resveratrol developments since early 2000s and it's been clear to me that Sinclair is an untrustworthy source of knowledge about longevity science. 2 Reply @cambodianriverpig7613 1 month ago wow!!! Reply @djimiwreybigsby5263 6 days ago Well now I've got a red wine habit but I feel younger when I drink it Reply @MsSuperww 1 month ago (edited) In other words people should not take that seriously what is branded as "science", because there is a huge difference between what is the "ideal of science" and what the "science practice" is. We must ALWAYS exercise good sense and use reason to approach what is divulged as "science" and "scientific results", because if it is irrational or inadequate it cannot be real Science. Reply @alexanderchikunov7593 1 month ago Thank you, Brad, for this work. Sinclair is a "pathological liar" for many years! I wish he'll loose his position at Harvard - and this is in the interests of Harvard, and the entire community of honest longevity researchers Reply @wmp3346 2 months ago Companies do their own research and due diligence. Don’t blame David for their greed Reply @MP-yt4cx 2 months ago Ok do is mnm bunk and wortless? 1 Reply @BeachProphet2011 1 month ago Damn. I have been conned twice in my working world and have sworn not to be conned again. The trouble with me has always been a nurtured willful naivete. But now, hearing this extraordinary takedown of someone who presented himself as a "scientist" quoting "studies" that confirm what the naive easily swallow (me), along with Rogan, Huberman and the rest of the shills in the health, longevity game. Color me a skeptic now. I'll try my hardest not to be a cynic, though, as it is up to me to use critical faculties to see through the con. Credentials to assure honesty, that's for sure. Reply @jonathanlivingston7358 2 months ago It’s hard to know what’s the truth when you’re not in the field. Reply @sterlingforbes3872 2 months ago Dr. Brad, I remember back when you questioned some of Sinclair's research and he blocked you on all social media... that was a red flag for me... as normally scientists would have no issue with someone questioning their work. Now it seems that he's turned to greed. Reply @funnyuniverse014 2 months ago You said half of the truth. I checked the research and resveratrol decrease testosterone level but on women. 1 Reply @Fearzero 2 months ago (edited) I still take 1g nmn daily. It definitely is helping my memory stay sharp. Reply @andreashjarksson1659 1 month ago Does NMN work though? Reply @steviedavey 1 month ago Thanks for sharing this video. I wonder if David Sinclair's former colleague's Matt Kaeberlein and Jeffrey Flier were just jealous of his $720,000,000 from Glaxo Smith Klein, and this led to the fracture in their relationship with David. I am inclined to believe David Sinclair's alleged "snake oil" claims about NMN. I have started taking it myself. Reply @nomvonglismerced4311 2 months ago Dr. Sinckair is not the only researcher touting NMN and the Yamanaka genes are not snake oil...sounds to me a video to create doubt to prevent anger from normal people not able to afford the youth procedure Reply @mr.s7031 2 months ago Ive always seen Sinclair as Mr Burns from the Simpsons Reply @endgamefond 2 months ago GSK is where i buy my tooth brush. Reply @acidhousemouse 2 months ago So does this mean that pterostillbene is worthless as well? Reply @Bodz2023 1 month ago This was 20yrs ago Reply @edangstrom366 2 months ago Resveratrol and NMN have been around years before Sinclair. Phytonutrients ( antioxidants) found in fruits and vegetables and Nicotinimide Mononucleotides have been proven to repair mitochondria . Have been taking this combo for many years before Sinclair ever made his claims about Sirtuins. Sounds to me like Stanfield is trying to confuse people about the use of these supplements as opposed to Sinclair's claims about Sirtuins. 1 Reply @kb7890 2 months ago Wow! mic drop. Brad, killing it! 2 Reply @BeijingBuzzz-China-Travel 2 months ago Anyone - is there ANY benefit / uses for resveratrol ? Reply @markhairston5884 2 months ago "No benefits of using small amounts of poison." Reply @ViCT0RiA6 2 months ago Cant believe sinclair was gonna pull a shkreli... 1 Reply @fingersm 1 month ago Turned Sinclair off cpl years ago 1 Reply @user-wl4kc8gq5i 2 months ago Wow, what and who can you trust on social media anymore. Reply @mitsuomits9077 1 month ago (edited) The fact that he was first rechearchin, testing on insects and worms, them jumped to mice (a much more complex organism) in his folloing study having the same results, is very suspicious. Reply @DavidGarcia-sr6xu 1 month ago can you make the next video in 90 sec pitch form lol good info tho Reply @samuelaubrey2612 1 month ago It's all about the money Reply @FPLChess 2 months ago I'm pretty sure the grass on my front lawn has life-extending properties. If any big pharmaceutical company would like to mow it and take the clippings away, they're yours for $720 million. Reply @scottmiller2591 2 months ago Sweet gig if you can get it. Reply @normano3573 2 months ago (edited) This is such an important field and it's distressing to know that there are people who are willing to take advantage of their position. Sinclair is a pariah not only to his colleagues but to the general public who often treat these researchers findings and opinions as gospel. It's taken a lot of time for some people to trust the research and the gains made in this field and not think it's full of snake oil salesman, and now you have Sinclair behaving like a nincompoop. Hopefully his presence on podcasts and conferences will be reduced substantially and we can focus on the works of the other amazing people involved in this field. Thank you for shedding light on this issue Dr. Stanfield. Reply @huckyduck 1 month ago Never liked him. Didn’t know exactly why until now. Gut feeling. Reply @clubdesalud1488 2 months ago And NMN? 1 Reply @robjsutton 1 month ago This is rather disturbing. Sinclair, what an absolute germ Reply @tientruong2007 2 months ago It's funny how anybody who looks shady ends up being shady. My intuition told me not to trust that guy. Reply @LuciousKage 2 months ago (edited) At last someone says something about Sinclair. this is why peer review should be check for every science claim Reply @benitodifrancesco7254 1 month ago Is any of the stuff he says about the epigenome and how it reverses againg true? Reply @quantumphysics4692 1 month ago (edited) Longevity seems like a final frontier in medicine, hard to measure and study in humans without decades of high quality research. All I can say is listen to your body, (how something affects your health over time and makes you feel). Second, listen to some of the wisdom that comes from traditional time-tested generational uses of different plants and foods, (many of these supplements are extracts of plants that have never been traditionally used on a daily basis or in large doses over extended periods. Traditionally used food plants and their polyphenol extracts are in my mind the greatest example of compounds being sanctioned by human use for fairly large doses over long-term daily supplementation). Third, add on top of these things the study of randomized clinical trials and meta-analyses on the pleiotropic pharmacological effects of these naturally occurring compounds. 1 Reply 1 reply @tonyc2489 2 months ago Not many will be sheading tears for GSK, maybe the shareholders. I'll have a bottle of the dye if they market it. Reply @seank6717 2 months ago So are you now against use of NMN/NR? Reply @WasatchWendigo 2 months ago Whoa, David Sinclair, lifespan god among men, or clearly a sinful and squirrely Bond villian? 1 Reply @prashanthkotamraju 2 months ago Is olive oil also snake oil? He mentioned oleic acid, which increases longevity which exists predominantly in olive oil. Reply @shinkurt 2 hours ago Deep down we all knew it Reply @jamescarbon3853 1 month ago Is NMN not good? Reply @willcook403 2 months ago He’s a great researcher and you don’t need to buy his stuff - which he doesn’t promote any brands from any interview I’ve seen with him - to get benefit. Whether he Does sell anything is seperate to if what he says, is true. I’m all ears of what he says isn’t right for good reason but, Hebert seen anything to the contrary although I disagree with his stance on meat. 1 Reply @homeontherange733 2 months ago It dawned on my long ago that while trying to research all things nutrition, that things started to look like a big massive infomercial:( This is why i quit watching tv for the most part. I quit taking MNM and Nicotinamide riboside a few months ago. Dropped the resveratrol. As a NAD booster i exercise , take Niacin and fast. Let food be thy medicine. Money sometimes can be the root of all evil. We all want health in a bottle because it's easy. There is no easy way to be proactive. Reply @OndrejL 1 month ago BRO, rogan should confront him Reply @aubreyj.tennant1123 2 months ago (edited) 12:00 Take capitalism and add meritocracy and too often you’ll find corruption. Great investigative work Dr. Brad! Keep us informed please! Reply @jimmyhvy2277 1 month ago The More someone is Educated , the Less we Should Trust them ! Best to Not Trust Any Human ! Reply @zakazan8561 1 month ago Matt Kaeberlein looks like a vampire, and vampires are immortal, so he might know more about longevity Reply @ritsukohairsalon 2 months ago Sinclair is genius in making money. Reply @stevebelzer4758 2 months ago Brad - great historical context - the YouTube channel “the Pulse “ claims the METROBIO building is EMPTY , no one working , no employees 1 Reply @yoniash 2 months ago What kind of anti aging supplements does he recommend these days? Reply @saadalikhan3031 1 month ago Every time I have listened to Sinclair I am thinking “He seems like a car salesman” (the cliche, no disrespect to actual car salesmen) Reply @bionicsix101 1 month ago So is the science on NMN weak like Resveratrol? 1 Reply @juozasjuozas 2 months ago But in what ways does Dr.Sinclair playbook apply to NMN? In contrast to Resveratrol, NMN has shown health benefits in elders ( plus not being harmful to say the least) and he did not try to make Resveratrol an FDA approved drug. I am sorry, but i am a bit confused. Reply @whats-it-all-about777 1 month ago Does that mean Elysium product Basis is useless ?… that is based on Sinclair’s research with Leonard Guarente - with the latter creating elysium Reply 1 reply @voxpopjuli 2 months ago My God, what a decay in this world.! You can no longer believe in anyone or anything.!! Where are we going to get to.? There is not the slightest dose of honesty or integrity left... Is there.??? ANY left... Reply @Texasgirl10 13 days ago I take NMN and feel so much better. But maybe I’m different. Idk Reply @MarkShinnick 2 months ago David Sinclair appears to be fair game. Reply @IvicaOS 2 months ago aww thanks man, I thought that guy walks on water…️ Reply @capitalallocation941 2 months ago Now do the entire US grant funding system. Reply @michaeltrumper 2 months ago i had followed Sinclair for a while a couple of years ago, but regardless of his experiments, some of his statements regarding diet made no sense to me, so my feeling was that if the basics wrong, I couldn't trust the rest of what he was selling. Reply @marcdunivan2436 2 months ago Wait! NMN is based on fundamentally flawed research? I started taking 500 mg per day of niacin because of this research! (with 600 mg of TMG) 1 Reply @ChadCilli 1 month ago I’m so glad that someone with a larger following is finally calling this out. I’ve been trying to tell people for years now that David Sinclair‘s work is fraudulent. Everyone in the community knows that his work cannot be replicated, but he has an amazing marketing strategy of bouncing around a different podcast peddling his snake oil. Reply @scrout 2 months ago Has Huberman updated his podcast re: Sinclair and NMN? Reply @eggbenedict-gt7mw 2 months ago Which tablet did GSK invent for sirtuins , none so why did they pay Sinclair Reply @matthiasl3807 1 month ago Such a shame. He was the first one I gave my attention in regards to longevity. Reply @TravisTellsTruths 1 month ago I started this whole story here by telling Brad all about how resveratrol was a fraud years ago. Right in these comments. The information actually came from Georgi Dinkov. Brad didn't credit me. But I want everyobe to know this came from Georgi Dinkov. A true G. 1 Reply 2 replies @nesne2167 2 months ago He always came off as sketchy when on Rogan. Harvard and he deserve each other. 1 Reply @andrewhall7176 2 months ago Fuck, I ordered some NMN earlier today. 1 Reply 1 reply @TheZombieGAGA 1 month ago Shocking bc reservatrol is associated with longevity Reply @clubdesalud1488 2 months ago Sounds like Sinclair would fit in well with those at the CDC Reply @yourbrain8700 2 months ago Shots fired. Reply @natesofamerica 2 months ago I'm guessing the fluorescent dye is toxic? Reply @tinacorsini 2 months ago there was always something creepy about him....something untrustworthy.. now I get it. Reply @Crimson34533 2 months ago I knew there was something shady about him. Just look into his eyes... 1 Reply @J.e.f.f.r.e.y 1 month ago So the $720,000,000 went to lawyers instead… Reply @dfoo75au 2 months ago Sinclair also said olive oil activated SIRT1. Whether that is true or not, SIRT1 doesn't extend lifespan in humans, but I wonder if people are taking a lot of oilve oil because of Sinclair. People like Bryan Johnson are taking at least 30ml of olive oil a day. Is olive oil the new snake oil as well? Reply @paulmk2290 2 months ago Damn! Well, thanks for that. What a rotter. That explains why I felt zero difference when taking Resveratrol and NMN supplements. Generally, I have a healthy scepticism when listening to white coats on YT videos, but the fact that Sinclair has the Harvard stamp on his credentials allowed him to go under the radar. They need to sever ties ASAP. Reply @floridamanbear5522 2 months ago Damn guy made over half a billion and he still out there scamming. Thank you for this. Reply @OIOnaut 2 months ago Triptopahan is involved the melanin acting photonic pathways. Reply @Mark_Trail 2 months ago You should reach out to Bryan Johnson for an interview. Reply @giuseppeagnello78 2 months ago Compliments. I feel sorry for those podcasts that still wearily convey Professor Sinclair's theories. Reply @donmulder8061 2 months ago NMN guy -- gave me high BP. Reply @apple1231230 2 months ago bummer, i've listened to a lot of Sinclair's stuff over the years and want to like him. I'm not totally convinced one way or another but now i am indeed skeptical and on the fence Reply @Kevindavegan 2 months ago Patenting a natural compound is illegal Reply @soggybiscuit6098 2 months ago Damn this plot like a m night shamalama dingdong movie Reply @LouVizz 2 months ago I don't really buy into the "reverse aging" stuff, but i have seen recent studies showing that 500mg NMN daily has shown noticeable improvements in areas over those who didn't take NMN. I do think it has benefits, but i find the anti aging & reverse aging as scummy marketing. Reply @seanbuckley9697 2 months ago Thank you for calling out David Sinclair. I know that it's not an easy choice. You know that it will draw some to attack you but you feel it's important to inform people properly. Reply @mickmiah7605 2 months ago Wow, a train wreck indeed. I think we were all taken in right from the beginning by Sinclair, my copy of his book has just been returned to me by a friend I loaned it to to get a grasp of what is being thought in this field, now I regret having passed it on. She had already started fasting hard when last I saw her before the Winter set in and I fear, when I break this news, it is going to be her trust that I lose. Another smaller, but to me, important cost of David Sinclair's perfidy. As to Resveterol the moment I heard it stressed cells I ceased to take it this, now, was a long time ago. Unfortunately, I had already bought a large stock , enough to last me a year, that I have only recently disposed of. I am saddened that David Sinclair has turned out to be a rogue and a conman. It feels just that his friends and, more importantly, the Dean of HMS refute him and his works as a charlatan. I suppose there is no fool like an old fool. TY Brad for all the work you do for us. Warm regards as always to the Stanfield Clan. Reply @thomasalderson368 2 months ago Sinclair got that Bundy swagger... Reply @GaryDee119 1 month ago Nothing in this video proves his intent. This field of research is insanely complicated and errors are made constantly. You believe his intent is to scam people so you’ve literally just shaped the narrative to make it seem that way. I don’t understand what you’re trying to accomplish here, but David has made it his entire life’s mission to give people better lives well into their old age. If you actually follow all of his work it becomes glaringly obvious that his goals and intents are pure. His findings have obviously worked for him cause that 55 year old man looks 35. I really can’t believe the amount of people in this comments section that have been following David’s advice for years, living better lives because of it, and now are throwing it all away because they’re blinding believing a random YouTuber. 2 Reply @zack_120 2 months ago Brave snakeoil salesmen, do they realize the consequences of lying which always got bursted in the end? Impressed! ! Reply @dunmwarupreachan4567 1 month ago Well damn. Back to the drawing board and blacklist Sinclair. Reply @JanRiffler 2 months ago What a smart cookie David is ! He took big pharma to cleaners. Reply @dorobo81 2 months ago I wonder how much jail time would be fair... Reply @sw4841 2 months ago I stopped following Sinclair after I tried NMN, and it made me feel like shit ..destroyed my energy as opposed to adding to it 2 Reply @yogi4319 2 months ago This video shows the difference between religion and science. Unlike faith, science requires empirical evidence that can withstand dissenting ideas and opposing theories. I'm not saying there's no room for religion and faith in our modern life. Only that we need to remain open-minded and always think critically. I believe everything is relative; Nothing is absolute in this universe. Reply @heshanlahiru2120 1 month ago Penicillium was a lab error too Reply 1 reply @joshmiller8392 2 months ago This is one of the rare cases how incompetence can make you almost a billionaire! Reply @Artzimer1958 2 months ago (edited) I never trusted David Sinclair. I always knew he was lying about those products. He should give people their money back. Reply @ianstephenson9471 2 months ago The problem for drug science is that it takes a great deal of time and open study to prove a theory. For example: mRNA is still untested. Reply @libertycowboy2495 2 months ago So disappointing. In the last year, I've gone from thinking there is a chance that I will get to enjoy a vastly increased lifespan to hoping that maybe for my kids. Sigh Reply @patriciagriffin1505 1 month ago First time I’ve heard this an incompetent genius Reply @HealingSongsAndPoems 1 month ago I stumbled upon this video and read many wise comments here. I wonder how many of you stopped taking all three—NMN, Resveratrol, and Metformin, or only Resveratrol as it maybe harmful? Reply @autisticautumn7379 2 months ago Always thought he was a bit ingenious. Reply @tombenson9357 2 months ago Does NMN work? Reply 1 reply @laurier3348 2 months ago Not all professors are incompetent. I repeat, NOT all professors are incompetent. Reply @heyyou9839 2 months ago (edited) So wait resveratrol protects against fatty liver? That’s pretty great - why gloss over it, Brad 1 Reply @WideAwakeHuman 2 months ago There’s a very simple rule in life that I have which protects me from falling for things like this - THERE IS NO FREE LUNCH. You can’t “extend ur lifespan by 30%” with anything other than hard work on sleep, diet, exercise, etc. If someone tells you this then you are safe to ignore them and, with time, you’ll be proven correct. Reply @nichobee 1 month ago Always had a gut feeling this bloke was a grifter 1 Reply @MVR777 1 month ago (edited) Putin's personal physician, a specialist in life extension who promised Putin a significant increase in his lifespan, passed away last year at the age of 77. Those knowledgeable in this area acknowledge two indisputable truths: 1) Putin is the wealthiest individual alive, and 2) Putin's utmost ambition is to extend his life as much as possible. This suggests that despite immense wealth, there are currently no known and verified methods to significantly extend human life expectancy. Anyone asserting otherwise without the backing of thorough research and concrete examples of success is either mistaken or misleading. Reply @xtian384 2 months ago Never trust a longevity expert who always uses more video filters than a make up influencer 1 Reply @RetroNerdGirl 2 months ago This is so sad! Reply @RJ-ox9jc 2 months ago Reply @myhumps2730 1 month ago (edited) Ok, David Resveratrol started a gas station named Sinclair. So, why did he choose a dinosaur as the mascot? Reply @blainebowling3303 2 months ago This type of behavior from Sinclair sets back the whole aging disease model and does an injustice to us all by discouraging investment. Reply @scottymackay1801 2 months ago $720m can turn anyone to the dark side. If Dr Brad was offered that.... Reply @paulharrisonadventuregearm5457 2 months ago Both resveratrol and NMN....the science behind the benefits of those two chemicals and their benefits were researched long before Sinclair came into the scene. It's not as clearcut as just saying both of those have no role in anti-aging, as there are plenty of studies outside of Sinclairs empire and tentacles that have found profound benefits. It's not clear either that resveratrol is justified as toxic, as many studies do show benefits in different areas, such as aortic flexibility among many other things. Reply @oxheadsoup9851 2 months ago I wonder if DS will take legal action. If he doesn't take steps to protect his reputation a lot of people will consider it tacit admission of wrongdoing. Maybe $720 million is enough for him to cash in his chips and head off to luxurious retirement... Reply @soccom8341576 2 months ago Well, didn't many people worship him? The social game itself creates these heroes (and scapegoats), which they then proceed to worship. To that I beseech thee - Worship no one nor thing. Be yourself, think for yourself and your community. Do not value results. Do not judge others. Place virtue such as honor and courage as the highest values. Reply @cfcasazza 1 month ago Just when you thought Harvard's credibility couldn't get any worse..... Reply @theunknownsamurai7426 1 month ago (edited) I don't know why, i never trusted him. 1 Reply @billbucktube 2 months ago Well, facts are facts. Subsequent studies to replicate Sinclair’s claims found incompetence. Ignorance ≠ incompetence. In this instance it looks like intentional incompetence to stave off future lawsuits! That is the real Sinclair genius. If intentional it is the worst example of morally reprehensible incompetence/fraud/ignorance for giving hope to the elderly. Reply @russella90 2 months ago Medicine would like to distinguish itself from pseudo-science, but longevity influencers employed by well regarded research schools undermines that effort. Reply @kingcubanolive 5 hours ago Soo can we talk about the new science? Epigenetics? I say good job. Hope we cure blindness next year. Fingers crossed Reply @user-yq8ck8yf3u 2 months ago Tried it felt sick stopped it. Reply @rg3412 2 months ago I saw a video interviews of David Sinclair and my guts told me this guy is a crook. Glad to see my instinct was correct. Reply @driftaaa 2 months ago Well, I'm glad i didn't waste money on those expensive NAD supplements... Reply @cryptobiose4809 2 months ago Reply @bastianbarria1134 2 months ago 1 Reply @guitawrizt 2 months ago (edited) Sinclair- Snake Oil x10. His 'incompetence' will follow him to the grave. Reply @gordonwillard4872 2 months ago Reply @spocklover110 2 months ago Is a good rule of thumb that studies should be confirmed by other labs? Reply @festermann 4 weeks ago He ignored you, so now its a personal thing. Fucking relax Dude! 1 Reply @zzzxxzzz3248 2 months ago (edited) I consume frozen broccoli sprouts and niacinamide and metabolize homocysteine with betaine anhydrous (AKA TMG) . No wonder pharmaceutical companies charge outrageous prices . Is nmn next ? Reply @Ded-Ede 2 months ago (edited) Lab error? These people are dangerous. They know what they are doing. Too bad we can’t jail them. Why is he even given a second chance to commit the same fraud. Reply @alexa.9446 2 months ago You did a convincing job establishing that resveratrol doesn’t work and may be harmful and that David Sinclair was either incompetent or cunning and fraudulent. Also that he’s getting some professional pushback and that we might want to be skeptical of his claims about NMN. But what about the evidence for NMN? Is it as sketchy as that for resveratrol? He could have been wrong about one and right about the other, no? Tell us more. Reply @Mysteri0usMem0 2 months ago he was saying to have some metformin too, i thought that was weird. anything unnatural is not harmonious with nature. Reply @drydz8670 1 month ago Wasn't there a recent scandal in the Harvard? It's regarding the research community. Reply @Peace_Guard 2 months ago I mean... it was always quite clear. He was dyeing his hair, claiming at the same time his natural hair didn't go gray and it would look the same not dyed, lol. He was hyping only NMN and resveratrol, even though when specifically asked about it, his supplement stack was much wider, with most other supplements having actually better history of results than those two. And then, it's inherently not corresponding with our evolution that plant compound like that have such effects. Aminoacids like glycine+NAC - sure. Resveratrol? Come on. Reply @bogse 2 months ago (edited) Its not stupid to ask huge sums of money but its stupid to pay. A solid bussiness man who looks 60+. Is there a court case against him? Reply @darwinmonzingo9738 3 weeks ago at least most of the substances may have lied about have been studied forever by others not relating to sirtuins. resveratrol is said to help blood sugar, fisitin perhaps also I didn't just listen to Sinclair and believe I researched all the stuff and claims to see what others learned it does without claiming anti aging or miracles Reply @frankliu2209 2 months ago So drinking red wine is now harmful now? Reply @unlearningcommunism4742 2 months ago Guy committed fraud - got 720.000.000. Guy debunked it - didn't get 7.2 dollars for that X) Reply @Heero5308 9 days ago Have you tried to replicate his paper in your own lab? Can you make a video sharing your data on your findings on how his papers are false? Reply @JamesBaylockJr 1 month ago Why does Dr Brad have such a hard-on for Dr. David Sinclair? He is constantly bashing him. Is it deserved maybe? It’s hard to say. David is essentially a competitor of Dr. Brad’s so he is hardly without bias. Also, I always live by the motto, “the truth is usually somewhere in between.” That is probably the case here, if I had to guess… 1 Reply @antoniopacelli 2 months ago Because Scammers are Liked by Little Ones...which Make Noises... Reply @performanceconfidence 1 month ago How can he continue to retain his leading position with this total conflict of interests How shocking. I hope this news goes worldwide for everyone deserves to know. Harvard's name has been totally discredited many times. A lesson in how easily Integrity can be lost. People need to know that such institutions are largely being funded by pharma companies to get the results pharma wants. Reply @Amanda_Blair 8 days ago Dang it. Is there anybody being honest on what we should be doing to live a long and healthy life? Reply @FunMushizzle 2 months ago David potentially cost us a decade of research time with his plausible deniability. Reply @chrisbronson5341 2 months ago Just what we all need... Extendthe life of flies . 1 Reply @stevenweint7893 2 months ago I get the impression that Brad really dislikes David. Reply 1 reply @shinkurt 2 hours ago If harvard cared about their name theyd drop him but... Thats how bad Harvard has become Reply @jacked_asian 2 months ago I'm not one to believe physiognomy usually, but Sinclair really does have an evil face. Makes sense. Reply @_jajajaja_ 2 months ago (edited) David also bangs on about NMN. Makes me wonder if that's a waste of time/money as well? Edit: just finished video, and yeah, I think I'll pass on NMN. Reply @hmbdata 2 months ago I foolishly bought and read Sinclair's book, and realized then that he was full of it. Glad to hear that his schemes are catching up with him. He belongs in jail. Reply @rab1df0x 2 months ago ive been saying this for years Reply @user-dl3oc7sb5s 2 months ago I have to own up that whenever I watched Sinclair on podcasts, I always felt that there was something unnatural about his demeanor, which made me suspect that he was lying. Now I understand why.! Reply @625098evan 4 weeks ago I'll let go of my excitment for MNM because these story seems to fit. however, I trust Sinclair more than I turst anyone at Harvord. Reply @adrienneg4231 1 month ago Sinclair to me felt like a creepy bastard. 1 Reply @davidchung1697 1 month ago I don't necessarily think Sinclair was intentionally deceiving anyone. But I'd be very careful in evaluating his claims. And this is not limited to his claims on resveratrol. His stance on NMN is also suspect. The next thing to be careful of would be his new upcoming age-reversal pills, which are supposed to use Yamanaka factors to reprogram aging cells to youthful state. Reply @drrush3421 2 months ago Hey no need for this surely 2 Reply @invinciblesummer4114 2 months ago I worry for Dr. Stanfield. Don't get suicided! 1 Reply 1 reply @places2shopdotnet 1 month ago Dr Stanfield, would you box David for miss leading the public? Reply @shamsdolatabadi3838 4 days ago (edited) Since the florescent dye seems to trigger sirtuins, why not try a study with just the dye? Maybe that dye will increase longevity? ️ #sirt1 Reply @brucewayne3633 1 month ago Some things may be questionable... but its not all completely wrong... although does appear a bit over-commercial... but so does Harvard Uni... just take with a pinch of salt... 1 Reply @-------------------DD 2 months ago Sinclair, well, I knew he was a phony when I heard him speak avoid hos grandmother It was so dishonest and contrived...I knew it was just a matter of time. Thanks for this video Reply @gumdocga 2 months ago Again, it’s all about the money. Reply @jimj2683 2 months ago I was telling everyone that David Sinclair was a snake oil salesman from the beginning. Charles Brenner is another one. And there are many more less known individuals doing similar stuff. Reply @pablogomez4959 2 months ago He is going to get millions selling the NMN company and then repeat the process for the OSK genetic therapy Reply @adamdebarros8675 1 month ago I went off David when he started saying eat hardly any meat... Interesting the term used here... Snake Oil salesmen... The next video that came up from Brad had discount link to a shop and on the page were ads for resveratrol and NMN... I think most of these guys are selling snake oil... There are a few who aren't... I try and listen more to them... Brad is sounding like a bit of whinny ... you know what here... I wouldn't take anything David Sinclair recommends, but props to him for shaking down a corrupt and evil pharma company! Brad you seem to think this is a bad thing... Good to see a little Aussie Battler ripping off big pharma! Reply @jekkleegrace 1 month ago Thanks for exposing the fraudster again, lest we forget. Reply @mokiloke 1 month ago Wow, i was really believing in the guy. Now im left very uncertain. Reply @orphica5739 9 days ago David Sinclair constantly pushes his belief that all of aging boils down to epigenetics because he literally thinks this is the take home message for why the expression of Yamanaka factors reverts some cells to a pre-differentiated state. The problem is that such reverted cells are not the same as young cells. These cells still possess a lifetime of accumulation of mutations that lead to higher entropy in cellular function and a higher susceptibility to cancer. He has claimed in multiple interviews that aging has little to do with mutations and that our cells have a "backup copy" that can be epigenetically triggered. But this is total B.S. and there is no backup copy for the original DNA sequence. He is referring to the Yamanaka effect but this is a deflection technique he uses to change the subject away from talking about DNA mutation, which will not be solved by epigenetic reprogramming, taking NAD, activating sirtuins, or anything else his lab is working on. To his disappointment, I am positive that we would ultimately have to genetically engineer every stem cell in the body to revert back to the original sequence if we ever actually wanted to reverse aging. But nobody every asks him about this in an interview because he takes advantage of what little is known by people who do not work in science. 2 Reply @skl5532 2 months ago If incompetence is deliberate and part of a scheme to defraud by making fraudulent claims how is this even a defence under US law?? What kind of convoluted BS is that. You can intend to feign a certain form of behaviour to overstate a claim and sell it for money to someone who believes you - how is that not caught under some form of crime. Or even a tort if any of this is true Reply @Holdem17 2 months ago If GSK was too lazy or incompetent to reproduce his results before giving him the money, the deserve it. Reply @paulevans2246 2 months ago I bought is book! I’m going to apply for a refund Reply @DJjussi1 1 month ago TLDR? 1 Reply @TWROC96 1 month ago Seems like David Sinclair is at the right university, Harvard University. Afterall, Harvard promoted to president a woman who was woefully under qualified even before it was discovered that she plagiarized the very few papers that she published. Evenmore, Harvard allowed this person to step down as president of the university but she got to keep her teaching position which pays a salary purported to be around $800,000.00. Harvard has turned into a university that hires under qualified and questionable professors. No need to go into the fact that the leaders of Harvard allowed their students to hijack the campus in support of the terroristic acts of Hamas. I hope all the rich alumni pull their money from these Ivy league schools because the education students are receiving is from questionable sources. 1 Reply @zeuso.1947 2 months ago In spite of all the fraud and lies, is it known whether NMN has a positive or negative effect on health? Reply @vmura 2 months ago lock him up 1 Reply @dool1002 1 month ago GSK shouldve placed that amount into an escrow until theyve proven that it worked then paid out to Sinclair. Greed and incompetence on both ends Reply @giorgikuprava1055 2 months ago He's clearly a snake. That guy should be in the jail. 1 Reply @johnhollar6001 2 months ago Not sure why but I have felt very skeptical about Sinclare. He gives me the creeps. Reply @muhammadalieesaa3379 2 months ago Whatever is good the pharmaceuticals will say it's bad & what's bad the pharmaceuticals will say it's good, if the pharmaceuticals are sincere then why aren't they picking up on the junk food culture & obesity? Why aren't they picking up on that? They'll be out of business if we wasn't sick. Reply @billsemenoff 2 months ago And what about the company that paid for it. They're going to get it back from consumers and government bailouts like they always do. With that much money on the line, they could have done their own experiments. Basically they don't care what's true, they'd be just as happy if nobody ever found out. Reply @b.7944 1 month ago David Sinclair remids me of Lance Armstrong for some reason. Reply @joliejade7783 2 months ago (edited) I don’t have trust much scientist from well known university, Harvard or other similar college does not mean they are better than others Reply @LeekowalskiWalker 1 month ago Interesting. Joe Rogan didn't seem to trust him I remember. Reply @quandary1382 3 weeks ago I bought into what Sinclair was telling us, I guess it doesn't take much to pull the wool over our eyes. All you need is to be someone who appears totally credible and doesn't have enough people with similar status countering what you are saying. Reply @ramblr5900 1 month ago Someone tell me the TLDR Reply @elvisbjork9275 2 months ago Sad to see that in the med community. On the topic snake oill... Do you have a video upcomming on Epitalon,been fuzz about since 2020 now, and even more lately. Is it something you've digged into? Reply @whodidit99 2 months ago Damn, I bot resveratrol before I watched this video. Reply @oneluv11 2 months ago So is nmn bunk? Reply @mitchelljack1590 2 months ago He always struck me as a charlatan Reply @lostpianist 2 months ago Poor mice Reply @zlatkojerkovic9456 2 months ago I remember seeing him making the rounds on different podcasts and thinking this guy looks worse at his age than my grandpa did in his 50s while working on a farm being outside. Then he looks like some kind of cosmetics were done because he doesn't look natural yet selling anti-aging. Reply @alexweinstein9798 1 month ago Why does Andrew Huberman promote David Sinclair? Reply @y.g.1313 2 months ago Sinclair and Harvard!!! A pair made in heaven. One tiny fraudster ($720m), the other one is gigantic!! Reply @zachariahstovall1744 2 months ago it seems you have a personal vendetta against Sinclair. Reply @himpoet 2 months ago (edited) I suppose if he did lie about not being consulted on that study, I wouldn't be surprised if he also lied about still taking it himself... unless he's in denial. Reply @EODHammer 2 months ago All you have to do is look at the worm and listen to him. Sinclair's always been FOS Reply @crowdancer5 2 months ago did I miss this guy specifying his sources or research??? I wonder just what beef he has with Sinclair Reply @NAW32Nicoisme 2 months ago im confuse Reply @austinphillip2164 2 months ago Until recently, I thought David Sinclair was a pioneer and I've begrudgingly changed my beliefs on that. Reply @roberthuismans3533 1 month ago Dude gave me the creeps on Rogan. Reply @Jsmith1515 2 months ago Sinclair has been SUCH a disappointment. Reply @FLPnotc 2 months ago So take flouresnt lighting supplements lol Reply @stellarblur 2 months ago Honestly I've been following David Sinclair and I can't believe your the first one to hold him accountable, Seriously should be sued Reply @robhingston 3 weeks ago the whole no idea of being Dr is to help others right David Sinclair's $$$$$ 1 Reply @BrocLarter 2 months ago Now do a video on the other longevity snake oil salesman, Peter Attia. Reply @jfox8888 1 month ago just to chim in, since its about Harvard, there has been alot of cases where studies were manupilated badly Reply @LJIsak 2 months ago Please, when you highlight text in your videos, you need to either: - read the text out loud so we can follow along - stop talking so we can read it ourselves If it's not important enough to read out loud, it shouldn't be highlighted in the first place. 1 Reply @Renatus_Eruditus 1 month ago Impressive and convincing argument. But it's not true - at least at 6:07. Two Peter Attia podcasts - one with Richard Miller and the other Sinclair - supposedly refer to the same article, revealing that Sinclair "lied" about his participation in the research. However, each podcast referenced a different article. This is the fallacy of Obfuscation, further exacerbated by the placement of Miller's statement before Sinclair's, when in fact the studies were published in reverse chronological order. Having dug into one of these claims, proving it false and deviously misleading, I have no reason to believe in any of the claims made by Stanfield. It would be nice to hear others' investigations into these claims. I dont want to do all the heavy lifting here. Aside from that, it's suspiciously ironic to hear Stanfield accuse Sinclair of peddling snake oil while he himself is heavily promoting his own brand of supplements in and across all his videos. It's sad. When doctors/scientists exploit their position of authority to invoke controversy by deceiving the public just to undermine their competitors and make themselves known - the public suffers most, and so does the integrity of science itself. 2 Reply @RandelOland901-ATT 2 months ago I'm just leaving a comment for the algorithm. Reply @cjkyricos 2 months ago Anyone with half a brain knew a long time ago resveratrol was dubious - BFD. Most everything else SInclair has provided works for me without a second thought. Reply @andrewwalker8985 2 months ago Claim to fame: trolling David Sinclair Reply @jamgamber0 1 month ago Dr Sinclair has been completely debunk in the video by dr Brad Stanfield: The David Sinclair $720,000,000 Train Wreck Reply @lookfeelbehealthy6320 2 months ago Sinclair's recommendations will put you into an early grave. He's the classic example of the false statement that more is better. Reply @whyjj1991 1 month ago A lot of people making claims to grab media attention Reply @Mokeygodo 2 months ago He is a grifter using the Harvard name. Charles Brenner phD calls him out often on Twitter. 1 Reply @sncsy 2 months ago Not a fan of Sinclair, but Brad's obsession with Sinclair is becoming exhausting. Reply @super_heroes 2 months ago Hating on Sinclair keeping you big as hell Reply @PTQ4Q4Q4Q4 1 month ago This is sad, i really loved his mesaage, now he just seems a money grubber 1 Reply @kennethlim210 2 months ago Why GSK can be so stupid to lose $720 mil for a con job? Reply @thomcarr7021 2 months ago Sinclair always reminded me of the "pyramid power" promoters of the '70's. Well polished and believable nonsense. Mark Twain would be proud. Reply @jamshedfbc 2 months ago I had problem with his theory about longevity which doesn't fit the 3rd world. Reply @ATT935 2 months ago the most disturbing thing in all of this is how this person is now professing medical recommendation to the public and is cited as the expert in longevity and healthy lifestyle... Dr Stanfield why don't you write to some journal that may be interested in publishing this story? the New York Times could be interested! if they publish it maybe we can put this cult of personality to rest... Reply @OIOnaut 2 months ago Mice are nocturlnal by nature. They did not control for non native EMR nor natural spectrum of light. Remember. We are talking about photo sensitive pathways here. No one is paying attentinon. Reply @tonynikolaos3527 6 days ago Ok, Brad thanks for the info- Sinclair has recently resigned as president of the Academy for Health and Lifespan Research (which he founded- but is still a member) yet remains Harvard professor and keeps his lab and research. Perhaps, he got drunk on "$$$" (the 720M from GSK were just not enough) and felt he needed to hype, to a degree of grose incorectness and flagrant exaggeration, without foundations the medical research findings, into luring sellable products and claims. On that count he fails as a human being- and a scientist to a degree, but lets not 'throw the baby with the water' and note that there are many resveratrol studies that do claim certain benefits, also NMN (NAD+) is good - i personally take it and attest to it- not that it matters- but matters to me) and perhaps his experiments with eyes in mice may hold hope for rejuvenation, etc- unless that one is also fudged and fake- in which case he needs to be stripped of the 720M (back to GSK), his professorship and doctorate should be revoked and reversed and he should go back to Australia and meditate his malfisance and misconduct in the hot desert for the rest of his life. But let's give the man a chance- maybe there is some good in his research- and he just has a "big mouth" problem and "attention seeking" syndrom. Reply @christopherstewart8071 2 months ago With 780 million on the line that company would’ve got it back if he did wrong. I known your sponsor is the NR guy Reply @DinoFancellu 2 months ago How much money does Sinclair need? Reply @c0nsci0usness 2 months ago Hey you can't blame David, maybe he is himself actually a worm. 1 Reply @Holonet01 2 months ago One thing that bugs me is that as much as I like DoNotAge's stuff, they're still heavily shoveling out "New" resveratrol supplements, despite this being obviously the case for years. Reply @ovidiudans 1 month ago So why not study the fluorescent die? Reply @gavinc7999 2 months ago Great video. Nice to see someone finally calling out David Sinclair for the snake oil salesman that he is. Reply @slaves329. 1 month ago Mate he reversed the age in mice Reply @alansnyder8448 2 months ago This is very interesting. Consider the following speculative on my part but I'm interested in replies from knowledgable people on this topic. I have been using a Whoop strap to monitor my HRV (heart rate variability) for the past 2 years. When I started I was not taking any supplements and was just exercising a lot and keeping healthy otherwise. My exercise habit is to swim vigorously for an hour 4 times per week. During this period my HRV averaged over a month would be in the high 60s to low 70s range. About 6 months ago, I started taking NMN and otherwise kept everything else the same. During the following 6 months my HRV fell from the 60s range down into the low 50s and even high 40s range. Now here is my question for knowledgable people. Could taking a supplement like NMN even cause something like HRV to drop? Is this is anyway a valid measurement? Replies from knowledgable people apprreciate. Reply @jetsetter8541 1 month ago The scientific community will label the guy for the fraudulent data manufacturing as an Ausie Viper Venom salesman There's a lot of Snake Oil Remedies on the market, he's not the first & not the last one. There should be the International Association of Snake Oil Salesmen 1 Reply @torpedohost 2 months ago says his net worth is 425 million. when i grow up i want to be david sinclair Reply @Seanonyoutube 2 months ago Harvard is a freaking joke. Reply @markcosgrove8365 1 month ago Don't throw the baby out with the bath water Reply @InvestinginthePhillyBurbs 1 month ago I bought it, did nothing Reply @maryroberts6311 2 months ago give the guy a break Reply @JoeRogansForehead 2 months ago Why would anyone buy this new company then Reply @axel_r_ 2 months ago "Hi, I will tell you something at the end of this video." Well, I am off. I'm not too fond of tabloid tricks. That is the same strategy you enforce other people use in whatever. E.g. Sinclair and greed. Reply @kryz8847 1 month ago Wow. I wonder if this video had anything to do with him getting canned from Harvard today Reply @johnharper3404 2 months ago Shaky foundations for this Professor Sinclair. For me one strike and you're out. Bye bye. Thx Dr Brad. I'm still your fan. Reply @philodox7599 2 months ago I am just commenting so that your video gets more interaction and hopefully people will see this fraud exposed #2 Reply @mrmark44 1 month ago Sounds like a hit piece. Jealousy? Reply @inejunta6569 2 months ago I always say the same things over and over but, if you have a dog, and you leave a sandwich sitting on the coffee table... your dogs eventually going to eat it. Who's fault is it. It's not the dogs... I know it's more about resources you have, and most people don't have enough to risk losing so they look the other way. Even if you have resources and support, it's still a risk. Kind of sucks that we rely on a few people to point things out... and ...after the sandwich has already been eaten. I think we need a better system to keep people from peopling, and it shouldn't be enforced by those few in the position where they can and they accept the consequences. There shouldn't be any. Reply @noybeeswax 2 months ago Instead of all the legal gobbledygook, are you saying NMN and Resveratol products are useless or Not? Reply @joperoz 2 months ago What percentage did he own of the company? Did he really make 720 million? Reply @SerenityReceiver 2 months ago From the first time I heard Sinclair speak. Maybe some of the money goes into resaearch that will further the field, even snake oil salesmen want a long and healthy life. Reply @doitbettermakeitfaster 2 months ago I realized he was a snake oil salesman about a year ago. But I was taking resveratrol regularly before that at that point because I wanted to extend my life, not hurt myself. I hope he is removed from Harvard's good graces and discredited for the greater good of the public. Reply @cardinalrule6810 2 months ago I didn't realize David Sinclair was a fraud... Reply @Mevmotto 2 months ago Yh you could tell he wasn’t sincere tbh Reply @AlexCat_Videos 1 month ago Sinclair️ Reply @terfalicious 2 months ago I bought his book on NAD/NMN in 2020. What a waste of money! While I am glad that I am not the only sucker victimized by this charlatan, it would be better if he just went to jail for fraud and stopped spreading lies. Reply @GrumpyCat8000 1 month ago sound like sinclair ran off on the plug twice, they steady calling he aint call em back Reply @kimjong-du3180 1 month ago I had a strong suspicion that he is a fraud Reply @Amritray 2 months ago He says one thing today, and another tomorrow. First it was pterostilbene, then he started recommending Resveratrol. His being a fraud is quite plausible. Reply @hugecocknballs 2 months ago It's a constitutional republic! You can't make this up! Reply @manindersandhu4900 2 months ago Sinclare is a story teller to mislead other easily Reply @ventureted 1 month ago Literally not what he's ever claimed at all. Blatant lies. He has never claimed resveratrol extends life. Reply @konsti300 2 months ago ok reservatrol is trash, but NMN is good, i take it everyday and it helps me to have good concentration mood and nice Belly 2 Reply @jaycarneygiants 1 month ago Sinclair is a snake... but the company that paid him really should have done their due diligence. Reply @RS-dq9pn 1 month ago I always thought Harvard med had ethical faculty , now I know better . He does sound like a malignant narcissist this video proves it Reply @philodox7599 2 months ago I am just commenting so that your video gets more interaction and hopefully people will see this fraud exposed #19 Reply @sippidi903 2 months ago So many people feel fooled by Sinclair and now eat everything Dr Brad is saying raw. Did you read the research? Did you measure NAD levels etc? I’m mad at Sinclair for trying to make NMN a drug but I don’t buy into this personal vendetta. Reply 1 reply @Subkubchik 2 months ago I knew this guys not to be trusted since I first time watched his podcast Reply 2 replies @TheMastertbc 2 months ago Harvard more like Hazard Reply @david-jr5fn 1 month ago What is David's Net worth Reply @Retronize84 1 month ago I got sucked in and bought resveratrol and NMN. It's all BS, does nothing and just gave me the runs. Reply @carolinelewis952 2 months ago I watched Sinclair for a bit, but noticed the vegan influence, so I left! 1 Reply @drewp1974 2 months ago What about his NMN claims??? Also fraudulent? Reply @philodox7599 2 months ago I am just commenting so that your video gets more interaction and hopefully people will see this fraud exposed #20 Reply @cadrniadrctkers 2 months ago Is there a level at which it is not toxic? And does it matter if it is the trans form? Reply @PavlosGiorkas 2 months ago Trust the science 1 Reply @baloruslusserson9840 2 months ago A conman heavily promoted by the YT algorithm. Reply @MunsterNox 1 month ago David talks nice, at least. 1 Reply @philodox7599 2 months ago I am just commenting so that your video gets more interaction and hopefully people will see this fraud exposed #9 Reply @philodox7599 2 months ago I am just commenting so that your video gets more interaction and hopefully people will see this fraud exposed #10 Reply @xxxs8309 1 month ago I always felt he was dishonest in his interviews Reply @bing-chilling1713 2 months ago If you either die a hero or ____, does it mean longevity is inherently evil? Follow for more shower thoughts. Reply @Kirill-xp9jq 2 months ago Early life section, anyone? Reply @myscreen2urs 2 months ago I knew he was charlatan from day one Reply @truthsocialmedia 2 months ago I was promised age reversal. I got age acceleration. what a ripoff. Reply @cryptobiose4809 2 months ago Can we leave these mices alone?. I swear to God eveything you give to them can expand their lifespan Reply @philodox7599 2 months ago I am just commenting so that your video gets more interaction and hopefully people will see this fraud exposed #6 Reply @hello3146 1 month ago Appalling. Did I misunderstand this? Did he swim in the waters of corrupted science for too long? Torturing mice for plausible deniability? Huh?! Reply @sunnygirl9691 1 month ago I never believed in any of his claims to start with because he kinda looked weird to me - not better, not younger. He just looked dishonest and kind of evil. Reply @nate_rndm 2 months ago This is an odd side note to everything in this video, but is it not the case that David Sinclair just looks untrustworthy? I tried to brush it away as just him having some odd facial features or "rbf", but weirdly my initial intuition seems to have been dead accurate. I'm trying to avoid bias by identifying someone who has well-established good character and also that sort of look, can't think of a single one though... Reply @heythave 1 month ago I didn’t know about this. I thought that he was legit. Reply @vladimirandrianov5930 2 months ago Ignorance is bliss, indeed :) Reply @matrices3987 2 months ago He's just like Bernie Madoff in more ways than one. Reply @philodox7599 2 months ago I am just commenting so that your video gets more interaction and hopefully people will see this fraud exposed #15 Reply @ramjee8211 2 months ago go head to head with him in a room...see how things go instead of shouting at him from afar. Longevity type influencers remember would have no traction without DS DA JR PA Ah whether they are right or wrong Reply @siggy7265 3 weeks ago Sinclair incompetent??? I'd say GSK are the incompetent ones for getting ripped off to the tune of 720 million dollars Reply @robertweekes5783 1 month ago Why did GSK pay nearly a billion $ before reproducing Sinclair’s results ? Reply @philodox7599 2 months ago I am just commenting so that your video gets more interaction and hopefully people will see this fraud exposed #18 Reply @FelixTweezer 1 month ago Dude you are no different. :) Reply @MmartinL 1 month ago This guy should 'loose the license' to practice research on the basis of malpractice. Reply @sebastienwinsor937 1 month ago so even harvard med is going down the drain. what David Sinclair Responds To My Resveratrol Video Fundraiser Dr Brad Stanfield 238K subscribers Join Subscribe 7K Share Download Clip Save 166K views 2 years ago #DavidSinclair #Resveratrol #Lifespan Here is my original resveratrol video: • Resveratrol – The Unfortunate (& Scan... Here is Dr David Sinclair's response: / 1493385121445076995 … Shop the Dr Brad Stanfield store MicroVitamin: A Low-Dose MultiVitamin & Mineral $49.00 Achieve your recommended daily intakes of vitamins & minerals without mega-dosing. Blended with Hyaluronic Acid for glowing skin, and TMG for exercise performance. With over 75% of Americans taking dietary supplements, multivitamins have become a staple in our daily routines. But have you ever stopped to question whether your multivitamin is truly giving your body what it needs? Introducing MicroVitamin: A Thoughtfully Crafted Low-Dose Multivitamin. Most multivitamins on the market today contain excessively high doses of vitamins and minerals, which may lead to potential side effects and wasted resources. MicroVitamin is different. We’ve carefully crafted our formula based on scientific research to help you reach the optimal recommended daily intakes of essential nutrients (both vitamins and minerals) while promoting a balanced diet and healthy lifestyle. A Balanced Diet Comes First: MicroVitamin is designed to complement a healthy diet, not replace it. We believe that obtaining nutrients from a variety of whole foods is crucial for optimal health. MicroVitamin aims to fill the gaps and support your nutritional needs when your diet falls short, ensuring you maintain a well-rounded and balanced approach to your health. The MicroVitamin Difference: ️ Embrace Moderation: MicroVitamin is meticulously designed to deliver the perfect balance of vitamins, minerals, Trimethylglycine (TMG), and hyaluronic acid. This careful formulation avoids overloading your body and eliminates the risks associated with excessive supplementation. ️ Achieve Glowing Skin: Our unique blend includes hyaluronic acid 200mg, a powerful ingredient known to promote skin health and hydration, giving you a radiant complexion from the inside out. ️ Enhanced Performance: MicroVitamin doesn't just provide improved cognition through balanced nutrition, it also includes 750mg of Trimethylglycine (TMG). This compound has been shown to boost strength, power, and endurance when coupled with exercise. Additionally, TMG serves as a methyl-donor and helps lower homocysteine levels, providing an added health advantage. ️ Trust in Quality: Our commitment to excellence means that MicroVitamin is made with only the highest quality ingredients, rigorously tested for purity and potency, so you can have complete confidence in the product you’re using, which means peace of mind for you and your loved ones. Quality Assurance We’ve partnered with a USA supplement manufacturer called ‘Makers Nutrition’ to produce MicroVitamin. Their facilities are GMP audited and FDA registered, so you can be assured that MicroVitamin is meticulously produced and thoroughly tested for quality. SHOP Dr Brad Stanfield 1,412 Comments rongmaw lin Add a comment... Pinned by Dr Brad Stanfield @DrBradStanfield 2 years ago Here is my original resveratrol video: https://youtu.be/JAFnD27ffqE Here is Dr David Sinclair's response: https://twitter.com/davidasinclair/status/1493385121445076995 I'm sharing his reponse so that you have another data point when you make your decision regarding supplementation with Resveratrol. Usual service will resume tomorrow when I release a video on Glucosamine (reporting on Tweets isn't particularly exciting) 110 Reply 28 replies @IvanValdez2010 2 years ago I am loving this public discussion. This is what science is all about—it is not about established “facts”, it is constantly evolving and we must be comfortable following the evidence. I am so glad your research and science communication is getting the attention it deserves. 434 Reply 27 replies @musikinspace 2 years ago The fact that you actually change your mind, and are still willing to change back given enough data is encouraging, and makes me really trust the information you give us. For that I hope you become even more successful. 78 Reply 3 replies @JanKosowski 2 years ago It looks like Dr. Sinclair is in a tough spot. Most likely, he cannot answer purely as a scientist because he's involved in related business deals and under pressure from other stakeholders. That's unfortunate, and I hope he will find a way to reply honestly. If not, it will harm his reputation even more than admitting he was wrong. 423 Reply Dr Brad Stanfield · 69 replies @UghIHateTheseThings 2 years ago Absolutely astounding work, I’ve been following your channel since before you had 10k followers and I cannot express how grateful I am for all your hard work and adamant integrity. I recommend your channel to anyone who asks where I get the majority of my health and fitness information. I cannot thank you enough. Cheers my friend. 12 Reply @cocis911 2 years ago I love how you are intelligent and play with a straight bat. You are 100% evidence led and you provide such an important service to us with your channel. Thank you. 78 Reply @consuelocampbell5613 2 years ago Really disappointed with Sinclair's response. Showing one paper that's 15 years old is irresponsible, particularly when he has a large following. There also seems to be a conflict of interest with the fact that he sold his company that promotes resveratrol for $720,000,000. 182 Reply Dr Brad Stanfield · 17 replies @DonkeyDonk6622 2 years ago Brad, you are my NUMBER ONE SOURCE for information in your field. The way you break down the latest research, no one else does it in that way. It's hard sometimes to hear something I wanted so badly to be true turned out to be not so exciting after all. But thank God you're doing it. 8 Reply 1 reply @jozefwoo8079 2 years ago (edited) Thank you Brad. So glad I subscribed for your channel. It's been very valuable and the fact that you change your mind when the facts change is very commendable. It might get harder the more "famous" you get (for some at least) but you are on a great path to keep that up 91 Reply 6 replies @mickmiah7605 2 years ago Thank You for pursuing this Brad. It is time that this all gets cleared up. Dr SInclair is doing himself few favours not confronting this issue. 13 Reply @CherryWaves1729 2 years ago Dr. Stanfield, it is extremely commendable how you research and present your conclusions with transparency and despite it being in opposition to the most revered scientist in this field. It must not be an easy thing to do, but it seems to me that your views on this topic are the most intelligent of anyone who speaks about resveratrol publicly. Thank you for your courage and hard work! You are a beacon of light in an era and field littered with misinformation. I hope that Sinclair realizes that the best move to make when one realizes they are wrong is to admit their mistakes forthright. 131 Reply 6 replies @oboyo601 2 years ago I cannot simply describe how grateful I came across your channel ! Your investigating work is Bravo ! Reply @johnny8774 2 years ago You are doing SUCH a great job mate! Love your content! 2 Reply @willcollins5660 2 years ago Wow, you are a gift towards the health/longevity community Dr. Bradford. We all love the work you do and want you to live forever because we value how much value you give to the world with unbias rigorous information. 3 Reply @aceyboy 2 years ago Thank you for having a backbone and reaching out to him for a rational discussion. His response shows how much he has riding on this and he won't admit defeat. He's always come across as more business/marketing focused to me which I think has blinded him from his bias. 8 Reply @RelhamG 2 years ago I' so glad you're doing this, Dr. Stanfield! Reply @felixsu375 1 year ago Thanks for your hard work making these issues clear. Reply @AporiaMagazine 2 years ago Well I know he's busy, but surely he knows that response is inadequate. 37 Reply 2 replies @hwaldman6479 2 years ago Dr. Stanfield, thank you for you original video and this recap. I think we all feel that the search for compounds to increase health span and life span is frustrating in that we appear to be in our infancy as far as research and reliable data is concerned. There are so many unanswered question and it is difficult to know which interventions will eventually prove efficacious and safe. As you have astutely pointed out that healthy lifestyle may be far more important then any molecule available currently and that various supplements benefits may simply be “icing on the cake” . Obviously a switch from treating diseases to disease prevention based medicine is necessary and a good first step. Issues such as whether compounds that are poorly absorbed (requiring absorption enhancement) and that are rapidly metabolized and eliminated is the body are being seen biologically as potentially harmful or toxic. Are compound that are readily absorbed and stored an indication that they are more acceptable to the organism? Does this explain why something like simple olive oil has possibly more potential health benefit based on studies then most “exotic” compounds many of which don’t occur in nature or aren’t normally a part of our diet? There is so much that remains unknown that it seems it is a situation of “roll the dice and take your chances” when it comes to choosing what supplements to take. The goal is to gain benefit without doing harm which isn’t an easily attainable goal if you don’t have data to make informed choices. I appreciate that you have, in your videos, attempted to help elucidate some of these issues. I hope with time and continued research that we will have the answers we seek. Until then roll the dice…… 5 Reply @balasubramaniamkajanan1085 2 years ago We just need a genuine Doctors like you ️ 2 Reply @johnely5050 2 years ago Many thanks for a very informative video dear Brad. 1 Reply @hotbit7327 2 years ago (edited) Dr Stanfield, you're showing a backbone of the true scientist here - searching for the truth. You were too optimistic and excited about some molecules/supplements in the past, in time you have revised your view, and it seems it's a constant process. You ask fact-based difficult questions. You're gaining my respect. Stay strong and true to science and your own limitations, like dr R. Feynman was. Great job! 56 Reply 3 replies @papyber 2 years ago Dr Sinclair should either announce that, in effect, he is proved mistaken, or otherwise show us clearly why not. However, it is probable that to protect his 720 million USD, he does not dare, for legal reasons, to admit his mistake. In either case his position is getting untenable. 87 Reply Dr Brad Stanfield · 20 replies @wellingtonbosharpe 2 years ago Thank you for all you do, Brad Reply @javadivawithdog 2 years ago Thanks for your thorough content. Appreciate it so very much. Reply @ScottChristensenabc 2 years ago Thanks, Dr. Brad. I appreciate your professionalism and diligence on bringing this to light and public. Rather hard to have faith in scientists who bag over half a billion and then move on to the next greatest “find”. I appreciate your work. 5 Reply @mr_x1703 2 years ago I'm more and more suspicious about David Sinclair. He is heavily involved in many, many corporations, trying too make as much money as possible. He's offering easy solutions, and i'm not sure, if all that stuff works in humans. i really, really appreciate your work. i'm glad i didn't spend money on resveratrol and all that other stuff he promotes. i will always be looking at everything he says from all sides. 64 Reply 5 replies @MyOrangeString 1 year ago Thank you so much!! Your work is so important!!! Reply @carolinecaldwell5184 2 years ago Thank you for providing up-to-date data Reply @Myperfectshell 2 years ago (edited) This was very helpful. I have listened to a lot of audio from Dr Sinclair. It’s challenging as a non-scientist to figure it all out. As a side note, I work for a tech company and we face things like this all the time. The response to a definitive rebuttal being backed up with something out of date or irrelevant, or extremely vague, and then the person disappears into the mist… It’s so frustrating! There’s likely som outside pressure. 9 Reply @garethroberts68 2 years ago I think your doing a great job exposing all the misinformation out there. I was taking metformin until your video explaining that all the claims that were made were not true. Also, the NMN/NR video that explains they did not expand human lifespan, but may increase human healthspan. 6 Reply @duncanjames914 1 year ago This is an excellent review. Thank you! Reply @dianavaldez3371 2 years ago Your Resveratrol video and why you stopped taking it was so epic, I knew there had to be a follow up conversation. Your research and analysis was fantastic. 2 Reply @itsdangeroustobeweakboii9045 2 years ago This is fantastic critical review of the research. Also very courageous to take on such a credible scientist who has clearly had material success in his work. Good job and keep up the investigative review of the research. 55 Reply 1 reply @elvira3919 2 years ago I wish we all could have doctors like you, Dr. Brad! Thank you tonnes for all you're doing, keep up the brilliant job! As for resveratrol and other so-called miraculous anti-aging substances, it's all about marketing, money, money and more money. Some people will do anything to gain profit for themselves, farmcompanies included 5 Reply @fitnesssoup7553 2 years ago I watch you and David both AND I will continue tuning into the each of you. Appreciate your content! Keep it up. Reply @barryh13 2 years ago Sinclair is full of it! Thanks for asking the hard questions Brad! Reply @gilbertgrejp 2 years ago Professional video Brad! Whatever is finally true I still respect Dr Sinclairs bringing awareness to the field of aging. 4 Reply 2 replies @demonslayer9016 2 years ago You are leaving the most important observation out of this drama. Resveratrol benefits WITH NMN...not simply resveratrol which David himself said are useless without the other molecule present. Nicotinamide Mono Nucleotide 21 Reply 3 replies @vetteluvnh 2 years ago Outstanding video! Thank you Reply @missunique65 2 years ago God Bless You! You are a beacon of truth - how refreshing!!!! Reply @glenn7306 2 years ago Dr. Stanfield, not sure how you don't have a million subs... IMO your research and videos are some of the very best on YT. Thank you for your deep analysis and always seeking and reporting on the true evidence... 7 Reply 2 replies @Ollie-qy3ll 2 years ago Great video brad 2 Reply @neerajbansal2717 2 years ago Continue the good work dear Doctor Brad Reply @TheRextc 2 years ago (edited) I know you said Dr Sinclair only linked one . There have been many studies showing AMPK activation by resveratrol way after 2006 (Cao et al., 2009; Villa-Cuesta et al., 2011; Do et al., 2012; Cho et al., 2014; Tameda et al., 2014; Shrotriya et al., 2015; Wan et al., 2016). That was in the same 20 years of growth and controversy article you posted. What do you think of those? 14 Reply 1 reply @johnny8774 2 years ago I CANT STRESS ENOUGH HOW IMPORTANT YOUR WORK IS MATE!!!!!!!!!!!!!!! For Sinclair its all about money! 3 Reply @williamdirk6205 2 years ago Thank you always appreciate your mind Dr brad 1 Reply @Philusteen 2 years ago Great stuff! I actually went on Sinclair's YouTube channel and asked him the same question as that tweet. Glad he responded - and a bit disappointed in the response. 2 Reply @owienbrowning3904 2 years ago (edited) To the haters that have posted on this thread..Be advised that Sinclair has made a fortune off of promoting a product that he knows might not work..And worse could be harmful...This needs discussed as many of us have followed his advice to the letter.. Everyone only wants the truth. 23 Reply 2 replies @daniellerobertson7989 2 years ago I've been watching David Sinclair's latest podcasts...I thought what he said Resveratrol was useful for was to introduce a plants' response to stress into your body, and he also said that any plant that has had a period of stress would do the same thing, and the gain was purely to encourage the body to do some longevity response of "lack" similar to the reduced caloric consumption that ramps up I think it was the sirtuan and M-tor activity to reduce aging... 6 Reply @defforadio6428 2 years ago Great job! 1 Reply @dekarselan4201 2 years ago 1:42 "it does not activate sirt1, it stresses the cell" If i understand this correctly, that low level stress is what leads to SIRT activation...care to elaborate there? 8 Reply 1 reply @DisturbedBurger 2 years ago "Lol I'm not confused" Savage response. Sinclair seems to be trying to redeem whatever he can from his investment with shill and heresy. As if the supplement market isn't already littered with exaggerated claims and diluted ingredients. 46 Reply 4 replies @tanjafromzurich 2 years ago thank you so much for your research! Reply @theentrepreneur8751 2 years ago Thank you so much for this 1 Reply @josephperlman6599 1 year ago I have been taking Resveratrol for over a decade. It is and was even known to be anticarcinogenic before Dr. Sinclair studied it. I have my MD but haven't done residency, and am very savvy about supplemens. 4 Reply @ahrmiller2003 2 years ago Thank you. Please continue to do your excellent data driven reviews. Reply @antokindness 2 years ago Thanks for all you do Reply @jar2520 2 years ago The question is… Why is Dr. Sinclair still pushing Resveratrol? Why can’t people adapt and change course as new information comes out? There’s just too much money and investment tied to it at this point. Also, It shouldn’t be viewed as a mistake because it was a worth while effort, but be transparent when the data doesn’t pan out. 28 Reply 11 replies @Rogue-Scientist 2 years ago Great video, as always Brad. This gives me more doubt about Sinclairs claims since he first resorted to his "horse poop" reply and now tries to slander you with missinformation claims. The response he typically resort to is that resveratrol has to be mixed in fat in order to be absorbed by the body, else the studies where they didn't do that doesn't count. But then in some interviews he has claimed that olive oil is a way more powerful sirtuin activator than resveratrol. So the question i ask myself, why even bother with resvreatrol if that is true? olive oil is cheaper and more tasty :) 27 Reply 2 replies @johnely5050 2 years ago Thanks Brad. 1 Reply @m.herluf1693 2 years ago Good work! Reply @timmothyburke 2 years ago My dad always said Harvard was run by scammers, well he used another word that I won't repeat. 4 Reply @virtuosa69 2 years ago I truly appreciate you and your integrity I bought resveratrol months ago but even after the expensive purchase my gut instinct was to NOT consume it. Thank you, Thank you, Thank you!!! 3 Reply 6 replies @thomasrobinson4401 2 years ago Nice one, yet again, Doc Reply @eddydjyoyo4172 1 year ago Thank you Brad for being brave enough to share the truth! 1 Reply @fatboydim.7037 2 years ago I don't take Resveratol myself but I do think he needs a substantive response for those who do take it. He still touts its anti-aging benefits. Even though other Vloggers don't 6 Reply 1 reply @frankasafscimone3920 2 years ago Dr Brad Stanford. I wish you would be more honest. Is this about likes and an ego war, or science? Please inform your viewers that currently Dr David Sinclair does not advise taking Resveratrol on its own. It is taken with oil, in conjunction with NMN. And the results are amazing, to say the least. 4 Reply 1 reply @johnburke9878 2 years ago Thanks Brad - please keep pushing for response from David Sinclair Reply @beauslatter411 2 years ago Thank you sooo much!!! Reply @jedwards1792 2 years ago Dr Brad - love our videos. Here’s a non-substantive suggestion: wear a darker solid color shirt, either a crew neck T shirt or a polo shirt would be best, not an open button down shirt. The color contrast with your light skin tone will make your videos more visually pleasing. 3 Reply @qwe7410 2 years ago My key takeaway from David Sinclair's advice is eat less frequent. Which he took an entire episode of over an hour of his recent podcast to emphasis. It's free, no commercial endorsement. On supplements, he did did a 6 minutes highlight on Resveratrol. As well as talked about the benefits of Fisetin, quercetin, spermidine, rapamycin, collagen, Hyaluronic acid, etc. Should we doubt those claims with a precautious note as well? 6 Reply 1 reply @arcshaw6396 2 years ago Good stuff Doc. Keep it up! Reply @KoltonLukes 2 years ago keep doing the good work!!! Reply @mimistar1427 2 years ago (edited) Miss the recap, and jump to Dr Sinclair response: 02:23 4 Reply @gloglos100 2 years ago Thank you, it’s so offensive to get such a response. Thank you for your work, you take personal risk putting yourself out into the shark pool with your well organised facts., it’s a relief I assure you to get cleanliness in thought in this area of BioPharma. 3 Reply @weiminyang7206 2 years ago I love this discussion and I shared it on my Facebook public. Reply @evedotcom 2 years ago I really appreciate what you said about just giving us another data point to make our own decision. As a highly open person, I feel like I am constantly juggling many often disparate claims and data points without coming to many grand conclusions. I like that you worded it this way. I guess this is the spirit of science/research. Respect. 1 Reply @williamm2032 2 years ago Since adding Resveratrol to my diet, my cholesterol moved from 273 to 193. My inflammation markers moved down, specially my CRP went from 5.23 to 1.01. Its effects on inflammation and in turn, cholesterol are undeniable in my case. The product I use is from Apex Energetics Resvero xl. Good luck with your research. 6 Reply 3 replies @mystikrebel1089 2 years ago I rather see both doctors talk it out in a debate.We need to be united overall to take the science forward 3 Reply @kasey5973 2 years ago New subscriber! So glad to find this channel. There is so much confusion. I know you are a respected Dr., but after listening to hours of your videos you would also make a great judge!! Reply @CatholicSatan 2 years ago I remember criticism of Resveratrol years ago (1997 approx.) as not being significantly effective because the molecule was too big (or whatever) to be usefully absorbed. Research since then has shown some 90+ RV compounds so it does not seem obvious to me what, precisely, is in supplements. In some cases, the supplement may be detrimental. There may be antioxidant, anti-inflammatory, even anti cancer activities but does the supplement contain the right version? And the effects can move from protective to detrimental depending on dose I read, and can also depend on age, whether you have a high protein diet and so on. The jury is out so far as I am concerned. 6 Reply 1 reply @abrahamnorthhampton3327 2 years ago Based on my (admittedly limited) understanding of the evidence, you have this one right. The lack of human trial data from Dr.. Sinclair's own lab says something too. I've removed resveratrol from my stack. 5 Reply 1 reply @celestebalut6177 1 year ago Thanks Dr. Stanfield for furthering the discussion of science. Well done. Reply @oboyo601 2 years ago Great work again man ! Reply @n3mo146 2 years ago I found a study by Yunjeong Gwon, Jisun Oh & Jong-Sang Kim in 2020 that, as far as I understand it, says that sulforaphane actually increases the growth of colon cancer cells caused by a P53 mutation. So how safe is it to take sulforaphane prophylactically if you don't know if you currently have P53 cancer cells in your colon? I am afraid that I will even accelerate the growth of mutated cells through the increased consumption of sulforaphane. 12 Reply 3 replies @gavintuohy9011 2 years ago Dr Brad, I used to follow Dr Sinclair's supplement regime by the book but thanks to your video I stopped taking Resveratrol a few months ago. I'm 62 and I have also switched to NR from NMN plus I've added NAC and CAkg to my supplement stack based on other videos of yours. Keep up the excellent work 5 Reply 3 replies @pistacchini 2 years ago Straight to the point thanks Reply @mikezimmermann2908 2 years ago Thank you Dr Brad, great information! I had started taking both NSM and resveratrol at 1g/day, resveratrol with 1tb olive oil after seeing Dr Sinclair on YouTube and reading his book. I am stopping both today thanks to your info. Maybe I will restart in the future if human studies show efficacy. I have also stopped taking ALA thanks to your video on that (which was recommended to me by Inside Tracker). I appreciate you taking the time to share this. I will support your research! 2 Reply @elisamastromarino7123 2 years ago I like Dr Sinclair. Even if he's wrong, he's at least taking an enormous step in the study of aging and why we should only "live to 80" when many other sentient species live so much longer. I think that's brilliant. Instead of just accepting it, he's at least started more people thinking and studying. Isn't that what science is supposed to do? What if Alexander Fleming had never asked questions about ...moldy bread and it's ability to reduce infection in wounded soldiers? Thank you, too, Dr Stanfield. I love open dialogue. 30 Reply 6 replies @DavidFlores-kq5hz 2 years ago Excellent information. Dr. Sinclair seems evasive and unfortunately intimates a level of flawed scientific proof. Very superficial response from him. I'm with you so far in your opinion/data. Keep it coming! You're doing excellent work. Thank you. 5 Reply @joyflips 2 years ago Thank you Dr. Stanfield. Facts are facts. We need to know the facts. 1 Reply @user-ff9gv3ml6t 5 months ago I concur with your assessment Reply @ratherrapid 2 years ago How does Resveratrol stress cells, raise chloesterol or interfere with exercise if the human body is unable to absorb it??? 4 Reply 1 reply @Lepiworld 2 years ago (edited) Would be disappointing if Dr. David Sinclair stays silent about that, especially as you offer him the opportunity to argue. But as said bellow, I'm afraid because he (presumably) knowingly gave an inadequate response. I'm just hopping I'm wrong. 32 Reply 9 replies @goraneriksen9461 2 years ago Now that we are in a investigative mood, I would like to throw some things out there. I have been annoyed by the massively aggressive online presence on some of the supplement companies out there, that are grasping on straws to sell their overpriced products that have no certificates or you have no idea where come from. Dr Brad Stanfield, You are promoting a company brand called Do Not Age, this company is established in 2019, this is registered as The Peace company in Derby, UK. This company is owned by a guy called Allan Graves. He and his father is behind the political party called Independent UK. This is a far right political party. All their molecules are sourced cheaply from China, the bottles the supplements comes have a GMP stamp on them, this GMP certificates are from China, and I can assure you you can buy these certificates online for 100 US$. All their supplements are synthetically derived, I am pretty sure. I have their Quercetin witch gives me stomach pain, and when you open up one of their capsules it looks very different that others, like for example from Lifeextention. This company has been careful to get a third party test for their NMN, and they are showing this off like there is no tomorrow, however I have not seen any certificates from the other supplements they are pushing. On Facebook, there is 2 different David Sinclair fan groups, one of them is called Dr David Sinclair Fans. This group is controlled by Do Not Age, Admin in this group is called Naomi Kirby. This person has 5 different fake profiles on Facebook. If you mention anything negative about Do Not Age there you will be censored, and you will be censored if you write anything positive about any other brand of supplements. Now this company is pushing a supplement called SIRT6, witch is supposed to activate sirtuin 6. Their "advisor" Vera Gurbonova has shown that flies extends their life with 5% by activating this. I mean seriously? What kind of bull Sh*t is this? You loose a lot of credibility yourself when you promote these kind of supplements from the new money grab companies, you surly get a cut of the revenue when customers use the discount code you are giving viewers of your videos. Would it not be smarter of you to use supplements from a company witch have high ratings on consumer lab's website that has a GMP certificate from the US? associating yourself with these new companies witch has no history and is dodgy will not help you out. Just my 2 Cents 126 Reply Dr Brad Stanfield · 33 replies @gardars9811 2 years ago Good job!! Reply @pbalerig 2 years ago Great video. Keep up the honestly Reply @banzaiburger9589 2 years ago I threw out my bottle based on your last video and I have no regrets. 10 Reply 1 reply @stephendoyle9210 2 years ago Don't forget that Dr Stanfield is still a GP in training and not a scientist specialising in this field. Nice of him to reference the research papers, but I worry that he is being too keen on filling up his YouTube channel with content in a field that has lots of uncertainty 3 Reply 1 reply @debstayblessed9549 2 years ago (edited) Couldn't click on this video fast enough! Thank you. I got a front row seat. The intellectual argument from two individuals on the top of their game is a tremendous blessing. P.S. I would like for Dr. Sinclair to come on your channel or for you to be on his. It's about the science and not personality. Bit surprised he has not responded to your invitations, yet. 1 Reply @fredturner4447 2 years ago Keep up the good work! Reply @paul715 2 years ago Thank you Dr Stanfield. Would it be possible to have a remote consultation with you. I am in the US. I think the issue with Dr. Sinclair is that he doesn't want to lose funding for his longevity research lab. You can't afford to be wrong when you get big bucks. 9 Reply @khushsingh973 2 years ago (edited) I think there’s a serious degree of malevolence directed towards Professor Sinclair. It’s pretty obvious even to foolish people. That’s not what I’m concerned about. My concern lies in the direction of an MD who has suddenly decided to become a self-styled advocate and influencer of people who will not question the rather overt barbs aimed at a known scientist who has given much to the scientific community regarding the nature of ageing. This intentional but oblique defamation of character begs the question: Why? And the answer emerges very quickly in one’s mental realm… sheer jealousy and anger at being ignored as if the influencer is a nobody… I can’t say I blame Professor Sinclair… but the worrying new direction is the canvassing of other scientists who are also gradually becoming inveigled to a personal enterprise of hate and destruction…they too are jealous participants in this picture… I’m pretty sure things are going to get very serious soon unless Brad pulls back. But he can’t afford to. He’s tied a rope around his neck and he can’t untie now because he’s hanging from the rafters… A shame because I used to enjoy these broadcasts… That’s in the past… but I dip in every now and then to listen to the diatribes… quite amusing… 4 Reply 2 replies @monicabroniecki7624 2 years ago Thank you! Reply @Dont_click_this_profile00 2 years ago woww sir you are so humble. love u sir. congrats 100k family i am also part of your 100k family. Reply @homesignup 2 years ago I think it's great you responded to him on Twitter. I've always wondered about the safety profile and efficacy of Resveratrol for females in particular, which is something I tried and stopped many years ago because it can interfere with female hormones in unexpected ways and I had side effects from it 3 Reply 3 replies @vasilismoutzouridis1609 2 years ago Even if he is wrong, he definitely did a good job on popularizing the possibility of controlling aging, which I think is a good thing 12 Reply 1 reply @remif9602 2 years ago Hello Brad, I am grateful for this video and the previous one concerning resveratrol. I am now a bit reluctant about David Sinclair talks. Besides, I am impressed by your insights! it's my first post in youtube ever or even on any social media, it means you bring a lot in my reflection. Congratulations for your integrity. Rémi from Versailles. Reply @anttihaikala8263 2 years ago Super, keep it up!!! Reply @seslews 2 years ago Dr. Sinclair is a MIT graduate/scientist, the head of a respected research lab at Harvard, has over twenty years experience in anti aging research, raised millions in research funding, authored or co authored many peer reviewed papers and a best selling book on the subject of anti-aging. You, on the other hand are a young MD (congratulations) and You Tube personality who has managed to raise a little over 40k for your dream research on Rapamycin, which is already being done by respected scientists at proven labs. Does he really owe you a response or explanations on his views? 9 Reply 2 replies @rzcheng 2 years ago I wouldn’t take Dr. Sinclair’s scientific advice too seriously. He hypes things a bit too easily. 14 Reply 1 reply @carinacullen3815 2 years ago I really hope that you continue to post these honest videos and that you don't somewhere along the line get paid off because these other "celebs" must be loaded and must not like the truth affecting their bank account.. Really appreciate you putting things into perspective for us regular people who don't have a science degree :P :) 1 Reply @Sadrul-Amin 2 years ago Go ahead Doc. We support you. You have not sold you soul like others. Keep us enlightened and wish your all the success Reply @fredettaboutit 2 years ago (edited) New here . Is he criticizing resveratrol just in relation to the nmn thing ? bc my dad uses resveratrol just as an anti inflammatory and it helps him alittle supposedly 3 Reply @johnknight2012 2 years ago Dr. Sinclair is 50 yrs old he's doing something right he looks 28 yrs old . Sure would love to see him talk about research. 3 Reply 4 replies @theedevil08 2 years ago I don't usually post, but I appreciate your content greatly and I learn something novel at every video. Reply @browneyedgirlFL67 2 years ago @Dr Brand Stanfield I am so glad I found this video-- just cancelled my Resveratrol order from Amazon. Thank you!!! Reply @spiderman233 2 years ago We have reached peak internet culture, a world leading scientist replying to an important message with "LOL". 3 Reply @theancientsancients1769 2 years ago (edited) I told Brad on here and others years ago that Sinclair was discredited by those in the field over a decade ago and that Sinclair seems to be having a revival by people new to this field. Dr Stanfield fell for the Sinclair hype too initially 5 Reply @dugmoon9275 1 year ago i am kind of new to your channel but i want to thank you for doing these videos. it will help common people to take informed decoctions based on data and not hype Reply @shelchicago8997 2 years ago Good work, doctor! Reply @AddisFeastethiopianfood 2 years ago I think you have a point on resveratrol claimed to be anti aging by dr. David Sinclair but i hope you consider his lifetime achievement and contribution to the aging science. You have to make a video about his achievement too not just his failure while trying disclose this scandal you also have to be supportive of his other works. I believe he dedicated his life to a better future of man kind. Thanks. 5 Reply 4 replies @Brainy-tn8wb 2 years ago What we need is objective, third party testing of molecules, first in animals, then in humans. Btw. i took Resveratrol, about 0,25 g/day for 15 years and i stopped it now. As far as i can tell it at least wasnt harmful. 5 Reply 2 replies @JonathanOvnat 2 years ago Would LOVE to see you interview Dr Sinclair! Reply @askingwhy123 2 years ago Commenting for the algo, but also to say I think you're doing a great job of "attacking the problem, not the person." We all run the risk of identifying ourselves too closely with prior results (the system incentivizes this), but despite any discomfort, the only way forward is to update your priors and move on. I hope the good doctor stops digging in. He has contributed a lot to the aging project and will hopefully continue to do so. 2 Reply @vonwolly2 2 years ago Well my dad had severe memory problems. I Give my father a gram and a half of resveratrol a day with olive oil. His memory has vastly improved. There are studies that claim that resveratrol after six months of taking it reverses brain aging by 10 years. It has done wonders for my father. You do whatever the hell you want to do I have seen great results from taking resveratrol. There's a lot of other people that take the same brand of resveratrol that my father takes that have experienced the same memory enhancing effects my father has found with resveratrol. So it's not just one person it's quite a few people. Most resveratrol out there is fake the stuff my father takes is 98% pure verified by third-party. Most people can't afford to take high doses of resveratrol especially the real stuff. 11 Reply 3 replies @yb7875 2 years ago Laughably, Sinclair has deleted his tweet. His silence says more than his words ever could. 4 Reply 1 reply @jackpaillard156 2 years ago Another great eye opening video Dr Brad, thank you! One day or another Dr Sinclair will have to face the truth...... Reply @Marc-zi5cq 2 years ago I subscribed, you seem alot more educated and trustworthy. Great channel based on facts. Reply @evlondocooper7318 2 years ago Disappointed that Dr. Sinclair couldn't muster up a more substantive reply than crying "Misinformation." The more these issues are debated in the public square by knowledgeable experts, the better off we all are. 19 Reply 3 replies @AlexanderMoen 2 years ago Sinclair indirectly addresses this on other podcasts mentioning that most resveratrol studies do not administer it properly. He says that giving it by itself has almost no bioavailability and no effect and perhaps even a negative effect. However, eating it with some fat increases its bioavailability 10 fold. So, for those studies, look at how resveratrol is administered first. 10 Reply 2 replies @nessigomesmusic 2 years ago This is a science debate at its best. thank you, Dr Brad Stanfield. Vert refreshing Reply @1337jusTi 2 years ago Thank you for your good work. I bought resveratrol long time ago, but stopped taking it shortly after, when I saw the negative effects on resistance training results. Reply @billb5732 2 years ago (edited) This is a fascinating discussion. I look forward to some final result whenever it becomes clear. Sinclair is charismatic and persuasive. He tantalizes us with a modern fountain of youth. And, yet, none of his conclusions have withstood the test of time. In popular circles he is well-known and everyone looks forward to his next revelation. In traditional medical circles he is mostly dismissed as an unproven supplement salesman. What is the truth? I hope we find out someday. :) 13 Reply 12 replies @SMUGAMER 2 years ago (edited) Thanks for the insight Dr. Stanfield. The information that Sinclair sold for $720M adds a serious potential conflict of interest. His silence and lack of proof/evidence to support his claims speaks volumes. It's also a very sad commentary as to who we can rely on when it comes to managing our own health. On a related note, If I paid 720M for something that didn't work, I surely would have had clawback provisions in the buy/sell agreement. 3 Reply 1 reply @gitanjalinandan 2 years ago Good for you. Reply @ThiagoPurusha 1 year ago (edited) Thank you. Reply @James-mk8jp 2 years ago This is what happens when you talk the talk before you walk the walk. He has built a brand out of himself looking noticeably younger (who knows what from) and has taken many victory laps before the consensuses have been made. 4 Reply 2 replies @kathysharp7551 2 years ago I would not be surprised if Dr Sinclair is bound by a contract not to say anything disparaging about the supplement. However, it feels like his reference to the 2006 study is borderline unethical. Perhaps silence would have been a better option. 14 Reply 3 replies @walterbates1654 2 years ago Feeding the YouTube algorithm. Another piece of the puzzle. Thanks again. Reply @swisstrader 2 years ago Fair and balanced. Well done Reply @shanongwynne6439 2 years ago (edited) pretty simple really, it's been shown it's important to consume resveratrol with an oil or fat to get the benefits I see no reason to address research where the authors chose to be ignorant of this known point of fact, it seems you've been ignoring this important point also. 3 Reply 1 reply @Adhara740 2 years ago Studies are often flawed but the doesn’t mean resveratrol is bad either. I always feel better taking it ️ 6 Reply 2 replies @freedomdividendnews5042 2 years ago everyone needs to like these kind of videos of Dr. Brad and also his comments. We need to challenge David Sinclair and give power to Dr. Brad Dr. Brad, please find us more ways to live longer. Thanks Side note - I would love if you can do a Saw Palmetto study to see if its as good as Finasteride using the NOW brand as a proxy since it has pumpkin seed and a few other things that you can debunk in one shot. Maybe also a topical solution 1 Reply @AdolfoContreras-xt2od 1 year ago Dude, you've got one fan here, great work! Reply @jacekpiterow900 2 years ago Even if Sinclair research turns bust he still was able to get the public thinking and talking seriously about that. Probably will sting same way as cold fusion idea. Hope that rejuvenation is not like fusion, always 40 years away.... 10 Reply 3 replies @Endurofek 2 years ago (edited) As a biologist engaged in research, I went through the publications published by Dr. Sinclair, which I have no doubt they are deceitful, thank you for exposing the matter to the public, i like your channel, i like your professional honesty. 3 Reply 6 replies @broncobilly6064 2 years ago Thank you Reply @kevingold1091 2 years ago What I think is that your channel has gotten so good it's primed to blow up! Be prepared for lots more subscribers! 1 Reply Dr Brad Stanfield · 1 reply @Rosie_Apple_Delight 2 years ago What about the Alzheimer’s study showing Resveratrol helped? What about the resverestrol study in bonobos? (I’m not a bonobo btw) Thank you Dr. Stanfield! 3 Reply @guuseh2918 2 years ago What do you really want? For Sinclair to clarify the issue or come on your youtube channel? Looks to me like it's more of the latter. I am with Sinclair and resveratrol because he takes it with members of his family. He is not an MD who is using every opportunity to let us know the latest and greatest products that Big Pharma has to offer. 3 Reply @raziaazad9628 2 years ago great work Bradlay, very disappointing that DS is not prepared to have a discussion with you Reply @deborahbehr3910 2 years ago I love your videos. Reply @CurtisHibbs 2 years ago Dr. Stanfield, please take this request as positive criticism. I'm making this comment/request because of the part at the end where you talk about your use evidence pyramid. My only motivation is to make your already excellent channel even better. My request is that simply that you try to be super clear about the indications against which you are judging the data. 90+% of the time you are, so this is hardly a criticism, but sometimes the wrong impression is given even though you are trying to be careful. I'll give one example... You were recently interviewed on the YouTube channel "Modern Healthspan". During the segment where you were discussing time-restricted feeding (intermittent fasting), you stated that the data shows that there is no benefit. Of course, you were saying there was no benefit in terms of life extension when consuming the same calories. You did explicitly say that at one point, but to someone casually listening they might not realize this. Many people (myself included) use time-restricted feeding for calorie control and weight loss (which has downstream healthspan benefits). I know that you were not speaking to this aspect at all, but many people might not realize this and come away with the wrong conclusion. I don't know if this is helpful to you, but I love the meticulousness of your presentations and, as I said, my only motivation is to help make them even better. 4 Reply Dr Brad Stanfield · 1 reply @benv.5170 2 years ago Maybe he's hiding behind his $720 million deal versus addressing the latest research on resveratrol. Seems likely 16 Reply 3 replies @ranevc 2 years ago I support your well evidenced debunking of merits of resveratrol. Reply @sorenandersen2159 2 years ago Thankyou sir Reply @Hail2MasterChief 2 years ago It's sad when one has to refer to a nearly 20-year old study. That's like 140 years in dog time or bio-hacking time, lol 4 Reply @paulwolf3302 2 years ago "Doctor" Sinclair can run but he can't hide. Keep the pressure on! 5 Reply @JD-im4wu 2 years ago Love your Cochrane Approach of Life Extension.You can't beat that! Reply @Margics 2 years ago Thank you . Frankly I expected a better response. I’m disappointed . Keep it up and thanks again. Let us know about the rapamyacin study. Reply @toom2141 2 years ago David Sinclair is Theranos Holmes 2.0 15 Reply 4 replies @jefflittle8913 2 years ago Personally I am reserving judgement. The original paper is behind a paywall, but the abstract makes clear that the claims were not reliant on a Sir2 pathway, so any criticism of the Sir2 pathway mechanism does not seem to be contradicting this paper. 5 Reply 2 replies @codforlife 2 years ago Thanks for this. I've been wondering about grape seed extract. Do you have any thoughts on this supplement? 1 Reply @thefpvlife7785 1 month ago We all thank you for your commitment in honestly wanting to help us live a better life. It means so much to us. Reply @jamgamber0 2 years ago Dr Sinclair is all about olive oil right now. Word by word what Hippocrates already said 2500 years ago. I don't think he will discuss with Dr Brad anything, and there is no need for that. The data speak by itself. 4 Reply 2 replies @thomasrebotier1741 2 years ago (edited) Until somebody can walk on stage with their 25 yo Golden Retriever, I will be suspicious of their claim to real life extension. Fulfillment of the allotted healthspan through basics (sleep, nutrition, exercise, stress control) is something else. PS: I eagerly await the result of the dog rapamycin study, and contributed to your trial; even though I'm not sure that rapalogs can do anything that appropriate fasting wouldn't. 10 Reply @primefetus 2 years ago Woah! Would really like to see Dr. Sinclair on your show. No doubt that would be informative. There should also be a yearly symposium on healthspan if there isn't one now. Reply @craigmarshallbodybuilding 3 months ago Thank you for always sharing good, truthful, and honest information. You are one of very few Dr's on Youtube that shares accurate information not influenced by personal preferences. All I hear lately is Carnivore, Mediterranean, or Keto as the main purpose behind their argument. As a vegetarian I want to know how to be healthier in my lifestyle and how purchased supplements based on your recommendations. Thank you for great content! Reply @swayp5715 2 years ago A disingenuous response by Sinclair. What a shame. 4 Reply @evanwalters6574 2 years ago Thanks Dr. Stanfield, I'm happy to see this video after watching the other resveratrol video last night. Dr. Sinclair says that Resveratrol acts in conjunction with NMN in many instances (podcast, etc.) what do we know about that interaction? Would be nice to address that because in this resveratrol series I see only singling out resveratrol itself. Does resveratrol enhance the NMN effects/absorption? If not then I think I'll stop taking resveratrol too and solely go with NMN. 3 Reply 1 reply @11kwright 2 years ago Thank youDr Brad Stanfield for continuing to bring health to us regular people in it’s true transparency and entirety. You really are making a difference in helping us regular people help ourselves. I have systemic sclerosis and my body was in the poorest of states one can imagine and experiencing literally all of the symptoms one gets with this disease, death knocking on my door. People don’t want to just take meds and do nothing. People want to help themselves get better and live a full life not hanging on a half life of our next doctor appointment and prescriptions keeping the pharmaceutical companies whilst we continue incrementally go down hill and eventually become part of death’s statistics. Had it not have been for YouTube and doctors such as yourself, I don’t think I would see myself in the position of running, breathing with a problem, not feeling like I’m half dead but fully alive due to intermittent fasting and fasting and all the information on these supplements / antioxidant molecules out there that actually make a difference at the cellular level. I speak for all in that we can’t thank you enough for what you are doing in helping clarify with current research papers to back up on what actually works and saving us money from buying things that are just claims. It’s great that you even go as far to inform what you yourself will be doing so we can make an informed decision of our choice and the info presented. You are a go to knowledge of reputable source and will be and already is a household name. Thank you, you brilliant and kind person. Reply @vernon121 2 years ago Best channel on longevity 1 Reply @matzefritz 2 years ago But Brad, to be fair you also have to adress the content in the paper David Sinclair referred to. For a critique it is not sufficient to just mention the year of the publication, it depends on the content of the paper. You should adress the content of it. And please be precise and not emotional, you also have changed your opinion a couple of times. 6 Reply 1 reply @davin8r 2 years ago (edited) I wonder if it's possible that a very small dose of resveratrol, acting as a mild cellular stressor, could provoke a hormetic response and produce benefits? For instance, would mild intensity exercise + very low dose resveratrol produce the equivalent effect of a moderate/high intensity workout? I've also been wondering if this concept is possible with hormetic pro-oxidants such as lipoic acid + exercise. 4 Reply 10 replies @drednac 2 years ago Hi Dr. Brad, I wanted to thank you for your effort to be transparent and give the most objective information. There still so much information about Resveratrol all over the internet as a supplement improving longevity and health while there seems to be no clear evidence that there are any benefits. Which is why it's so hard sometimes to find good information, even when the intentions are good you never get the full story. For example it's really hard to find information about downsides and side effects of different supplements all you can read about is long list of benefits, but that is just so dangerously incomplete information. I had to completely roll off my entire supplement stack just to find which of the supplements are causing my health problems, it's complex. You cannot just stake stuff because it has possible 'benefits' it's just so insufficient as an information to decide to take something regularly into your body. I am planning to take regular blood tests, but even that might not be always sufficient to find out if some of the supplements I may take are harmful for me. The whole mainstream data about supplements are very misleading. Reply 3 replies @olyav5819 2 years ago Thank you for trying to clarify this with DS. Hope he will address this one day. In fact I think that he should. Reply @Tystros 2 years ago I like your videos, but I wish you'd be a bit less click-baity with your video titles. In this case, Sinclair did not actually respond to your video. He most likely did not even watch your video. He just responded to someone saying that resveratrol stuff is confusing. Saying he responded to your video is just not true. 19 Reply 3 replies @luckyhanger1326 2 years ago you have thrown allot of bullshit out there.....any slander involved? Some of the things you say are accusatory. You could present this in a manner that makes you look like you have some tact. I actually stopped trusting you some time ago, this is not helping my opinion of you or your work. Unsubscribed! 11 Reply 2 replies @danimoh5809 2 years ago Hey Brad, thanks for the update! What is your opinion on Oleic Acid, seeing the resveratrol data? 1 Reply 1 reply @jasminawad 2 years ago Thank you very much for the two very balanced videos. This is exactly the way science is supposed to work. Logically analysing research data and updating to get the best information. Then devise new tests and trials. Dr. Sinclair really looks very bad for not responding. I will be much more critical of anything he posts now. 2 Reply @TheBeautifulcanvas 2 years ago (edited) I love a good scientist battle as much as the next, but the stakes are pretty high here. Perhaps there are legal [financial] reasons and contingencies that prohibit him from publicly acknowledging that the supplement has failed. However, surely he's aware that continuing to misinform the public puts him in direct conflict to "do no harm." 7 Reply 3 replies @yb7875 2 years ago Don't lose your cool and keep factual. People will see through Sinclair's bizarre behavior eventually. I myself was also drawn into the longevity thing after listening to him speak but when I stopped listening and started reading I saw that none of his claims really held up in the scientific literature. 17 Reply 7 replies @AngieStonesPhD 2 years ago Totally wonderful discussion of unethical research. Thank you. Reply @joesilkwood4958 2 years ago Wow !! Thanks we need the truth!! Reply @irinadiamant3812 2 years ago (edited) Is Professor David Sinclair supposed to answer to every self-proclaimed YouTuber who is seeking attention and cheap fame. Ridiculous claims of Dr. Brad Nobody. Do we trust a scientist with 20 years of experience and credentials from the most prestigious universities in the world or… We believe a New Zealander MD (who’s background is completely unknown to us) talking out of his garage? Pathetic. 3 Reply @charlesdwight6096 2 years ago Dr. Stanfield, I found your video on Resveratrol very helpful. You made it very clear. Prior to that, I was hearing conflicting information/misinformation. Dr. Sinclair himself addressed the Resveratrol issue in a Joe Rogan podcast where he claimed to have been vindicated, referring to his 2006 research that you referenced as proof. While Dr. Sinclair has done a lot of good research, I find that some of what he promotes in interviews appears to be compromised by his reputational & business interests. 1 Reply @ShadeViking7 2 years ago most excellent. Reply @Cenot4ph 2 years ago I dont like Sinclair in this discourse one bit, he must have financial stake. I'm out following this guy. 3 Reply @GodDieux 2 years ago If it’s an issue then why don’t people of consequence question him about it. You are fixated upon this and relatively a light weight. Are there any heavyweights pointing out the same issues… or is it only you and your specific fixation that is not being addressed adequately. 3 Reply 7 replies @staceyschmidt2200 2 years ago Dr. Sinclair is a Rock Star! Reply @pedecia 2 years ago LOL. Thanks to you Dr. Stanfield I am not confused anymore. Reply @arash_LA 2 years ago (edited) I’m not a Dr. Sinclair fanboy or whatsoever, but wow, Dr. Singclair has a lot of enemies lol . To have that many enemies, you must be somebody! All of the scientist Dr. Stanfield mentions in his videos are getting paid to speak out against Dr. Sinclair. Simply look up who their sponsors are to get your answers. The funny thing is that all of the people that are against Dr. Sinclair are around the same age as Dr. Sinclair, but Dr. Sinclair appears to look 20 years younger and much healthier than them. It's all just a money game/war between some large corporations and sponsors, and these scientists are getting paid to speak out against one other. For example, simply do some research about Dr. Brenner and see what all he is involved and has invested in, and then you will realize why he is against NMN and instead promotes NR. Even Dr. Stanfield, it seems he has some hatred towards Dr. Sinclair as well. It is so obvious in his videos when he talks about Dr. Sinclair. Why? God knows! Lol Who the hell should we believe? 5 Reply 2 replies @mk7723 2 years ago Your video title is misleading. David Sinclair did not respond to your video. He responded to someone's tweet. In trying to diminish someone else's credibility you diminish your own with click bait. 3 Reply @joelapatrick 2 years ago Love it Reply @adambryan1146 4 months ago i love this guy period, hes not pulling the wool over our eyes, hes just telling us the facts, thank you dr stanfield Reply @levondarratt787 2 years ago Thank you for posting this. I think we're blessed that in this day and age we have so many data points, user feedback and open discussions going on, and worldwide. 20 years ago it would have been a book, published and then the discussion would have ended right there. The more these things are being discussed, validated, criticized, the better. 7 Reply 1 reply @Ollie-qy3ll 2 years ago Great video brad 1 Reply @byrnedegrandpre8884 2 years ago Thanks Brad. Reply @stefanosk8976 2 years ago I unsubscribed.I am from your first subscribers. your obsession with confronting dr sinclair makes you look rediculus. 3 Reply 1 reply @ExbotHero 2 years ago (edited) Why should he spend any time responding to all the random critics that may choose to do a video on youtube? Seriously; He is Professor from a world-class university. This is an OLD discussion he has to spend a lot of time debunking. The fact that you try to bait him into a debate (which he decline) to raise your own credibility isn't proof that you are right and he is wrong. Resveratrol clearly has a huge heart-health benefit. Numerous studies on that in with you avoid talking about 100 % of them, interesting, right?! (Bias?!) The heart-healthy effect alone has an enormous anti-aging effect! After all, declining heart health is something everybody tends to get as a part of the aging "disease". Notting in the date you put forward debunk that. To me, studies with that type of a clear agenda from the beginning (to smear a person by addressing small unimportant premisses instead of looking at the whole picture) only create a pointless discussion. Not even worth the paper they are written on. Why should he spend any time on an old topic debunking more or less his sworn enemies' attempts (rigged studies - their ways of climbing up over him by smearing his name) when the so-called new studies don't present any new evidence on the totality of the effect?! (What we see is just the same old argument in a new dress - Newer intended to investigate the important fact.) They had the agenda to prove that Dr. Sincliar is wrong from the start. That's all. To me, you clearly avoiding the fact that the people who publish this have a track record of having a bias towards Dr. Sinkcliar. Why not raise that as one of the variables you put forward in the video you make?! Strange right?! Wait... Not really... You got your own bias. After all, you are working to put forward your own alternative to his solution?! Helping other people with an invested interest anyway. At the very least you working to get a click on Youtube and Patreon who pays for your advice right?! It's funny (telling) how a person who has no Ph.D. in the aging field hasn't taken own all the positive videos on the subject that still generation him a huge income now jump ship using all the old argument from Dr. Sincliars enemies just to make more money on a subject that he has no formal training on. It is quite sad how easy it is to see through some people's agenda. You are the one with the real ego problem in this discussion, Dr. Brad. No formal education in the field. Now using some random studies proving nothing, from your self-made, cherry-picked timeline (cherry-picked studies) just to get more clicks and revenues from people here on Youtube. 3 Reply @kenelliott8944 2 years ago Great vid, I have been thinking about Dr. Sinclair's research ever since I listened to your first video on resveratrol and I agree that the evidence does not support taking resveratrol for lifespan. I do hope you're taking care of yourself, as I would have to say . . . you're not looking well in this video. Best to you, Dr. Stanfield. Reply @farina6479 1 year ago Thank U !!!!!!!!!!! :) Reply @sanderarens3507 2 years ago Dear Brad, I normally really like your videos but that you now lower yourself with this type of non-scientific opinionated messages is disappointing. I know by now that your no fan of David Sinclair but stick to the facts please. You don’t belief in resveratrol but you do not have any study to proof it. Poor studies w/o result doesn’t mean that it doesn’t work. It is fair to say that you don’t see proof so far but the story around the company that stopped the production sound a little conspiracy like. There are many reasons companies stop production (monetary driven). So, keep on making great videos and please stop picking on dr Sinclair with only circumstantial evidence. 7 Reply 1 reply @michaelrichards9710 2 years ago You are a full time GP who does part time researching other people's research and Dr Sinclair is Harvard professor with a large team. No wonder Dr Sinclair does not respond to you. I know who I would believe. Definitely not you! 4 Reply @salqubeq5203 2 years ago You are good in your field. we need more critical thinkers like you in the world so that science can do its job correctly. This is exactly how science should work in moving towards the truth, instead of being hijacked because of other motives. Thanks for sharing Reply @doubleeagle9722 6 days ago I started Resveratrol after listening to Dr Sinclair. But your video enlightened my misinformed therapy. Good that you are so evidence based in your approach. As for Dr Sinclair, with 700 mil for him, I hope he will stand up for the truth. Reply @TKILPATRICK100 2 years ago Why should David Sinclair have to respond to your stupid videos? treat them with the contempt they deserve? 6 Reply @svetlanarottier5983 2 years ago Real science should be transparent. Waiting for Dr Sinclair's response. Thank you Brad. Reply 1 reply @davidhaylett1810 7 months ago Well said Brad. There is a lot of BS out there and it appears that many on line influencers are more interested in their own financial gain than in the facts. I’ve subscribed to your website and have switched to yourself as the number one trusted source for health related information. Many thanks for your efforts. I’m already saving money on Resveratrol and have stopped taking it, together with high dose multivitamins. Reply @Akira-nw4jl 2 years ago Dr Brad I consider you extremely credible and are truly a professional in your research. Good work. Reply 3 replies @jeremiahhandcock1795 2 years ago This is what science is, your videos are very beneficial and I find them extremely valuable. It is like a map, guiding me through reading papers in university. By the way, I am currently very interested in metformin for its effects in extending life. Could you publish a scientific review on metformin? 2 Reply @inejunta6569 1 year ago Thank you for taking the opinions and egos out of the data. It seems like it is inevitable that people get to a certain level then cannot be regulated in a way. I start to lose faith in how strange but predictable things seem to be. I appreciate people stepping up and addressing conflicting information (at the risk of being smeared by monkeys with money) It's the only regulation we really have at this point. Reply 1 reply @damo7776 1 year ago Great video and informative. Me personally I have been still am taking Resveratrol. It has been yielding some great benefits but what works me might not be the same for someone else Reply @damo7776 1 year ago Great video and informative. Me personally I have been still am taking Resveratrol. It has been yielding some great benefits but what works me might not be the same for someone else Reply @mr.2Creative 2 years ago Thank you for another great video. Can you please make a video about the supplement sources companies. There are some comments about donotage not being a legitimate company, most of the supplements coming from china and not to be trusted etc. Who do we trust? Where do we buy our supplements? 1 Reply @andrewgillen5636 2 years ago Thanks Dr Stanfield, Would be nice and one would think prudent that Dr Sinclair has an interview with you. He couldn't be that busy that he doesn't have 10-20 minutes in a day to clear this up for the punters! Reply @petert8456 1 year ago It's clear Dr Brad is more evidence based. Highly concise and documented videos. Thanks Dr Brad. Reply @Wilczek2 2 years ago Thank you Dr. Stanfield for all your work. It's obvious that Dr. Sinclair cannot be trusted. Reply @fitafita7931 2 years ago You're amazing.... Reply @draconisdragonheart4248 7 months ago I'm so glad that the truth is coming out. I wouldn't waste my money on Resveratrol. 1 Reply @APBCTechnique 2 years ago Thanks Doctor Brad, I’m stopping reversatrol 1 Reply @annieg.7051 1 year ago Hi Dr. Stanfield, thank you so much on this. This really clarifies other information I have read on this supplement. Unfortunately, I just ordered the started kit from donotage and it comes with resveratrol which I do not plan to use. Good thing that the started kit was on sale. lol Does resveratrol also have negative effects on hypothyroidism? Also, I noticed you take berberine. I am in my early 50's with no diabetes and was thinking about taking this as preventative instead of metformin...whats your opinion? Any feedback greatly appreciated? Reply 1 reply @lunchbeast9899 2 years ago Dr Stanfield, thank you for pressing your questions. I have (had?) a tremendous amount of respect for both you and Dr Sinclair and follow both of you closely. I originally thought this would turn out to be a simple misunderstanding and looked forward to the two of you getting together for a friendly meeting of the minds to clear it up. Instead, I find myself shocked and extremely disappointed in what appears to be a deliberate and poorly veiled effort by Dr Sinclair to sidestep your pointed questions with references to outdated material. I am quickly losing confidence in and respect for Dr Sinclair. These are NOT elementary questions beneath his expertise and unworthy of his attention - they go right to the credibility of his research and reputation. Keep of the good work. Reply @abdallaakoud1166 6 months ago Thank you for your genuine scientific information which is evidence based. That is how science should be addressed. Reply @christophdenner8878 2 years ago Thank you so much for the valuable work you are doing and all the efforts you put in there! The response by Dr. Sinclair is of course disappointing, I guess there are financial interests or his ego in the way to admit data has changed since then. I recall an interview with Dr. Sinclair not too long ago where they asked him about the controversy and he replied he's nevertheless still taking his daily resveratrol (but it did somehow not sound honest). Reply @Thebusysuperhuman 2 years ago Excellent video The data is what the data is. I think Dr Sinclair and yourself should have a live discussion Reply @francoistourigny3006 2 years ago Congrats Brad, you are tenacious, I hope so much that you succeed in this project, Sinclair is a kind of scientific Prima Dona! Hard to bring him on a inconfortable table, debating seriously with you, on this topic!, sooner or later, for the sake of his credibility, with you or elsewhere, he will have to explained clearly, and honestly about this product, he have a responsibility toward all the person like me, that invest on that product for their health, hope you succeed Brad. Reply 1 reply @ArminTadj 1 year ago thank you so much for clearing this up (I am a MD) have you got a video / paper on nmn ? Reply @wmp3346 2 years ago Lol = laughing out loud, thanks for the info Reply @davidlakhter 2 years ago thank you for this contnet Reply @normanbuitta2171 11 months ago Im glad you're holding Dr Sinclairs feet to the fire - he has also shown his true colors and the same playbook with NMN- Although at its base, NMN research and anecdotal outcomes seem to actually have some substance. In the end, I believe your service to others and integrity will serve you quite well in the community. Have patience, Dr. Stanfield!! Reply @nz7921 2 years ago (edited) I only watch Dr. Sinclair for his soothing voice ...he literally helps me fall asleep... Reply @sim1.22 3 months ago I decided to take resveratrol after following the hype. I became very unwell. So glad for people like you Dr Brad Stanfield Reply @888cromartie 2 years ago Thanks for this, please keep up the detective work. This appears to be just the tip of the iceberg. Reply @rg3412 1 month ago It’s David Sinclair’s “I’m not a crook” moment 1 Reply @AntiTheismForever 2 years ago (edited) Thanks Brad for publicly calling out David Sinclair on this issue. He still openly advocates the use of Resveratrol and Metformin for life extension and I wondered if the scientific evidence backed his conclusions. Resveratrol is not a cheap supplement and I will happily remove it from my supplement stack. As for Metformin, I prefer Berberine as it's better alternative for those who exercise regularly, has fewer side effects and does not require a subscription. Sinclair's use of metformin though focuses on life extension rather than blood sugar and insulin resistance management since he does not have to manage such issues. Would be interested then to understand the science backing Metformin as a life extension supplement. 2 Reply @ultraman6450 3 months ago Thank you for your video. I'm curious if Pterostilbene also affects the body in the same way as Resveratrol. Would you suggest to be careful about Pterostilbene as well? Reply @ginch158 2 years ago Dr Brad Would you please comment on whether or not Pterostilbene reacts the same as Resveratrol in not activating SIRT1. I recall you yourself where including Pterostilbene in your personal stack of supplements. Therefore I’m curious whether you continue to advocate taking it or not after the new research. 1 Reply @SirTenenbaum 2 years ago Wonderful job, Brad! I'm so glad you're getting this information out there so people can make informed decisions. 1 Reply @petersoncarlos1050 2 years ago I lIke this kind of discussion Reply @Quickrex 2 years ago Dr. Sinclair is a reputable scientist and Dr. Brad Stanfield graduate medical school 2015. Who of them looks the healthiest. I would say Sinclair. I don't think supplements are the Holy Grail. Eat healthy food. Be active, lift weights. It's a YouTube channel, same O same O. 2 Reply @robertkaufman6184 7 months ago I am 75 years old and would like to be part of your Rapamycin study when it goes live, if possible. Thanks for bringing important data to my attention. 1 Reply @3333lexx 2 years ago In closing. let me thank you again on behalf of the physicians and scientific. Members Of the American Academy of anti-aging medicine Best professional regards and God bless you for your good work Sincerely Ronalds Klatz MD,DO 1 Reply @dritanvarfi5274 2 years ago (edited) Fair enough! A response from Dr. Sinclair is due to clear up the confusion regarding resveratrol. Reply @shawna7813 2 years ago Shawn A 0 seconds ago Been taking it for 5 years. My cardiovascular system feels sped up on it, a caffeine-like effect. Do i look much younger than my actual age? I do. I'm approaching my mid 40's but still look like I'm in my early 30's. Maybe its my strict healthy diet, or maybe its the resveratrol. I also drink a lot of green & white tea and also take turmeric, CoQ10, fish oil and aged garlic extract... 1 Reply @SonySato81 2 years ago I hope the longevity science succeed and Dr Sinclar accepts to go on your show this century or the next 1 Reply @eldel5806 2 years ago This seems like a public version of what science is all about. Submit, critically review, discuss. Hopefully, leave the feelings at the door. Great job Reply @matth9939 2 years ago I ran out of kindling tonight. Used my Sinclair books to get this fire started. Cozy fire, blanket, melatonin, ashwaganda, magnesium, and a good Brad YT channel. 1 Reply @DavidRMandel 2 years ago Bravo, Brad! Follow the science, not the hype! I won't be ordering any more resveratrol. Reply @opheliaelesse 5 months ago I was wondering on david sinclair's message, no time and knowledge to check by then, didn't really like him, too ... This information here is better, my gut approves Thank you Reply @winstonallen6933 2 years ago I would advise Dr. Stanfield to distinguish between using transresveratrol vs.regular resveratrol (the later being the least bioavailable). Also, I would also advise Dr.Stanfield to to challenge the many companies that sell transveratrol on the market. Reply @missunique65 2 years ago Brad -please ignore the naysayers! What you are doing is epic! Cheers! Reply @garybrooker312 2 years ago You a re always looking to one up everybody. 1 Reply @Frazer247 2 years ago Dear David, The truth will set you free or so they say. Dear Brad, Thank you for telling the truth as you have always been in your scientific investigative analyses. Sincerely yours, Frazer Reply @damo7776 1 year ago Great video and informative. Me personally I have been still am taking Resveratrol. It has been yielding some great benefits but what works me might not be the same for someone else Reply @thesystemera 2 years ago Good. Finally you two communicating? Reply @hhgg28 1 year ago just to thank you. Reply @DH432hrtz 1 year ago (edited) Ya ya your both pretty! I think what's dangerous is there are thousands of people who are enjoying there best lives. If you feel it works then it works. I've never got healthy from listings to two grown men argue over such nonsense. If you don't like Resveratrol fine but remember many do and I'm one of them. So suppliments are just that supplementation. If Resveratrol got you put the potato chip down and eat les bad snack food maybe got you to go for a walk and feel good about yourself good. I ve followed David and I think he's helped many people find a way to get active. It seems as though two highly educated Dr's need to find common ground rather then grandiose videos of there there. Reply @anmayo917 9 months ago Thank you for being trustworthy Reply @evitafrancuz232 2 years ago Dr Sinclair is very smart and will understand that it doesn’t look good on him, his research and related business to run and hide . Addressing it with you is the only way to keep TRUST and faith on his research even if there are some faults. Reply @PeerCoxFashionRec 2 years ago What about the OPC supplements? Any better than resveratrol? Thanks Reply @mrwolf750 2 years ago I am waiting for the next video on the health benefits of fluorescent dye. 2 Reply 1 reply @JTheoryScience 7 months ago I was so hyped by david sinclair and the NMN/Resveritrol announcements he made, but ive been very disapointed with the lack of effects after trying it and it does not appear that Bryan Johnson's Blueprint protocol includes either of these molecules. I consider Bryan Johnsons approach to be very noble and altruistic and Sinclairs approach to be rife with conflicts of interest. I will be stopping Resveritrol and NMN for these and many of the other reasons you mentioned in your 2 Resveritrol videos. Thanks Dr Stanfield. Reply @MrHornet72 2 years ago I think Sinclair is not 100% trustable. But for u Brad I will give u 110% trust in your videos they are so honest and helpful full of data that we need keep it up! U should have a million subscribers or more. Reply @binks3371 1 month ago Sinclair did say in his post "Misinformation everywhere" and then spread some misinformation himself. Legally, he did not make a false statement. 1 Reply @aloevera7422 2 years ago Oh snap! Reply @immortalityIMT 2 years ago Let no man be above science 1 Reply @andreic3765 1 year ago Glad I saw this before buying into it lol Reply @quepadrequemadreeducadores7237 2 years ago I agree with you. The only thing is not clear... Resveratrol is then a regular suplemment? Would it hurt u? Reply @virginiapantoja8993 2 years ago it depends on the people that takes. to some, it works. but not for everybody. Reply @captntorthenaer-do-wellcad3191 2 years ago Your integrity is intact. Reply @3333lexx 2 years ago Dr. Stanfield Thank you for your excellent work analysis and demystifying many of the basic science concepts surrounding anti-aging medicine longevity and maximum lifespan I think you’re doing an excellent job my head is off to you I’m wondering if you were a member of the American Academy of antiaging Medicine? If you are not I urge you to become won the academy now has a membership of over 30,000 physicians scientists and health professionals from over 120 different countries around the world and your membership would be very well received I can guarantee that as I am the president and founder of the A4M the worlds largest preventive medicine medical society that since 1991 has been leading the charge for advanced preventive medicine that is focused on a cure not simply palliation. Your in-depth analysis on resveratrol and Dr. Sinclair is most appreciated as we must be clear as to who is a true believer and who is forwarding true science and true clinical excellence and whose opinion we should be giving significant weight to I am following your post with great interest and I thank you again for your service to humanity to the public and to the scientific community for your work please feel free to contact me should you like to attend our next scientific. conference I would be happy to have you there as my guest Reply @funnyfyr 2 years ago I'd love a video of you going through the evidence pyramid with examples from longevity science Reply @localrachel 2 years ago Dr Stanfield is one of the best channels on youtube. I would love to be interviewed with you regarding my specialist topic: magnesium. Reply @sarahhopkins577 9 months ago Hi Dr Stanfield. I am taking a vitamin supplement powder that also has some resveratrol in it, 10mg. I could name the brand but not sure if that's allowed. anyway, do you think that amount is harmful? 1 Reply @tnvol5331 2 years ago Does grape consumption have benefit for cancer or cardio disease. Reply @TheVigilantStewards 2 years ago Do you have any info on Fulvic Acid/Shilajit and TRS Zeolites for detoxing? Reply @paulgennaro2001 2 years ago Jerry! Jerry! Jerry! Academic Jerry Springer! I love it! Dr. Brad, keep it up and establish those facts! Reply @davidderidder2667 10 months ago We are now a year later, how does your critique hold up now Brad? Would appreciate a response. Thanks for your ongoing discussion of these topics. Reply @Vgallo 1 year ago How come you haven’t done a video on bena gene? I find it really helpful for energy, although I have a bad case of restless legs atm, something is wrong with my body and I have hypoglycaemic effects as well as aching in my Calves whenever I eat, along with restless legs every 2 hours when I sleep, so bena gene really helps with my energy levels but it worsens my issues with restless legs, so there’s a trade off for me, but I suspect for most this wouldn’t be the case. Reply @appleorange559 2 years ago What do u think about animal based diet? Reply @mytuube11 2 years ago sandra kaufmanns book the kaufmann protocol has 25 articles sources after 2009 for resveratrol and she has included it as one of her top 10 supplements and its benefits. Reply @FortuneCookieLies 2 months ago It improves the quality of life more so than the duration from what I have studied. I think Resveratrol is likely good for stressing the body to reproduce cells early but there is a limit to how many times you can reproduce a cell without it dying. Resveratrol is likely a good tool for pushing cell reproduction and in small doses repair. But in high doses it is not good. I think if you are already exercising there is not really a need for resveratrol and it is basically pill based exercising effects that stress the cells. It can be good for ocular and post recovery from a head injury. Reply @Hades44481 1 year ago Well, my feelings were correct with sinclair. I watched so many of his talks and many things did not sit well with me about him and his new NMN supplement they were working on. When he stated they want to sell it as a drug I knew it had nothing to do with longevity and anti-aging. At that time I said something is fishy here, why would he be wanting to take a supplement, that clearly is helping people and market it as a drug? As time went on I learned more and had this feeling it was all about the money, control, fame and power over NMN. Singlair should have left it alone! This is one area he will lose and his reputation as well. Trying to control the market all for greed is something everyday folks can see right through! If he wants to push "aging" as a disease and longs to have it treated as such, controlling and patenting NMN first is the wrong way to go about it. This makes me so mad I can spit! Rest assure, I will never listen to Singlair speak again! 2 Reply @mahriathompson6204 2 years ago Good for you! You are very much needed to all of us!! I think his response is poor, insufficient! He doesn’t study as well as you!! Thank you for bringing out the latest information! Dr Sinclair is not the guru he is portrayed to be!! Thank you, for doing the latest research! Debunking Dr Sinclair’s out-of-date information! Reply @jakelylehemlock 1 year ago Don't you have to take NMN with Resveratrol? For said benefits? 1 Reply @branjay3588 2 years ago Would combining extra virgin olive oil with resveratrol negate the negs of resveratrol? 1 Reply 1 reply @jemhuckabee4222 1 year ago I'm getting great benefits from taking it! I'm not a doctor, but the people have their say...sometimes the facts belong to an individual, whether they are getting benefits or not, regardless of the lab studies. 1 Reply @Scottlp2 2 years ago I don't take it and have no clue if it works. I do know Dr Sinclair has made several comments about correct form/storage of resveratrol and solubility. Anyone know if these were taken into account in studies showing lack of effect? 2 Reply @andrewp7490 2 years ago Dr Brad Stanfield >>>> Dr. David Sinclair. Good job Dr. Stanfield, you are doing the right thing. 1 Reply @kingbile5846 2 years ago Hello Brad Sir, I am 21 years old guy from India. I was suffering from insomnia for 1 year now. My doctor given me a prescribed antidepressant name dosulepin 75 mg. I wanted to know weather it reduce my life span or can cause some serious disease that can lead to death later in life Reply @myramiller8734 2 years ago Should we be sending our resveratrol back where we purchased it and will they give us a refund? Reply @micridg 2 years ago Recently bought 2 bottles of Resveratrol and only half way through the first bottle. Not taking another pill! The idea that it counters the good effects of exercise has finished it for me. It is such a pity! 1 Reply @robertrinehuls9099 2 years ago Doesn't Vitamin C as an antioxidant also interfere with exercise, particularly muscle building? Reply @homemadebykathycriniti4847 2 years ago I have used it for 2 years. Recently struggled with its viability and confusing dosage. I am 48. Healthy and rather for tho probably pre menopausal. The one thing it did do for me was give me a bout of huge energy. Why would this be? 1 Reply @nickcsaszar9554 2 years ago I am unwilling to criticize Dr Sinclair, Dr Stanfield, or any other individual for contributing to to any discussion. But, I will critique the overarching problem, that is, the inevitable implications of our psychological tendencies to group our ideas around beliefs. This is the fatal flaw and the crowning jewel of the human condition. We are thinking AND feeling creatures that have evolved to navigate the world using both. This reality makes all of us susceptible to 'human' error. It is an inevitability for which the only antidote is open discussion, free speech. I thank Dr Sinclair and Dr Stanfield for their contributions. Reply @Indianahillclimber 1 year ago Seems like the clear winner is the florescent dye. So where can I get this florescent dye? 1 Reply @john-di1mz 1 year ago If you are not absolutely 100% honest, crystal clear with what you're saying and otherwise way beyond reproach with all data presentations and dealings involving the influencing of consumers then you are RIGHT IN THE FIRING LINE...and we know what happens then don't we??? Quite frankly l was also consuming Resveratrol after following David Sinclairs presentations but now l have stopped.... Like many others are now saying it's great to have another set of eyes and a nice loud and clear voice alerting us to the fact that not all is as it previously seemed with some of this research. Shame, l like David Sinclair Reply @ibrahimkhalil5194 2 years ago I recently read his book, Lifespan and I purchased both Trans-Resveratrol and NMN... I'm kinda confused right now. Any advice at least on NMN? Thanks in advance! 1 Reply 1 reply @dikeledimogobe5117 2 years ago Thank you for this clip When you talked about Resveratrol raising cholesterol, I believe you. For the 1st time in history My cholesterol and sugar levels were very high the last time I checked ever since using Resveratrol. At some point I thought it was caused by COVID injection, little did I know. Reply 1 reply @idonavon6513 2 years ago (edited) Hi, At the age of 32 I'm taking everyday niacin, d3+k2, vitmin C, brocomax, biotin and lions mane mushroom supplement. Do you recommend anything else for general health or reducing blood sugars? and is there a way to keep my hair color from going gray? 2 Reply 2 replies @robp7785 2 years ago Show me an incentive and I’ll show you a result… Well done Dr S! Reply @damiandamiano3651 2 years ago but resveratrol only works with quercetrin combined and oleic acid , did you try that combo once ? Reply @JS-nj3vw 2 years ago Have you started dyeing your hair? Reply @jenniferhart3941 2 years ago I just tried a resveratrol/NMN supplement because of a David Sinclair podcast last Thursday and it gave me a migraine headache all day which I hardly ever get ️. Reply 2 replies @stevestephens8925 2 years ago hello. i'd like to know your advice on taking sulforaboost regarding exercise routine. i'm 73, do some hiit (5minutes) x2 a week (i'm diabetic and too much hiit really jacks my blood sugar) and walk between 4 to 8 miles a day 5 or 6 days a week. i also do some weight training 2 or 3 times a week. thanks....really like your videos as well. Reply @tomg5405 1 year ago Continu like this! We need real people saying the true not people try to sell or make money with ud by giving us false informations Reply @joshneil2314 1 year ago So I’ve read a lot of the comments here n may I ask what is the serious side effects of resveratrol So weird because I was in Holland&Barrett today had a tub in my hand but put it back just to do more research on it…. Reply @charlesgreen7408 2 years ago Maybe we should look at the Florescent dye! Lol Reply @arielmalanga9303 2 years ago I'm not a trained scientist but I'm educated and can read a scientific paper. (My sister has a PhD in chemistry and I always consult with her if I'm confused on some of the finer points.) I'm another person on Twitter who often has exchanges with Sinclair, although my comments usually involve a good measure of sarcasm. Why? Because Sinclair is not an honest broker. He's a businessman primarily and he's looking more and more like a charlatan. Furthermore, I don't think Sinclair will ever debate you, Dr. Stanfield. He considers himself to be above questioning, and would rather spend his time sending messages to his supposed "clients" like Beyoncé. He never misses chance to mention Harvard or MIT - although he attended neither. I have had it with his nonsense and would never buy another book by him or contribute to anything I think would profit him directly or indirectly. Keep doing what you are doing, Dr. Stanfield. As for me, I keep an eye on the work of Dr. Valter Longo and legitimate scientists, doing legitimate and ground-breaking work. 2 Reply @machinized 2 years ago Obviously the response was off-topic which clearly indicates you are correct. 2 Reply @petemarx1129 2 years ago (edited) Brad - the myth killer ! Kudos for open mind and bravery to go against one of supremely backed by the mass media 'scientists' who always seemed quite fishy to me. With weak response Sinclair just confirmed our worst fears that whole game with resveratrol and quite likely NMN/NAD is merely hopium for consumers and path to big bucks for Sinclair and co. It seems that a little bit of legal investigation on this case would help to secure better consumers protection. 2 Reply @tomballey8906 2 years ago Please run for president. 1 Reply @henrikmadsen2176 1 year ago THIS IS SOLID CRITICISM !! = SOLID SCIENTIFIC DEBATE .... GREAT WORK Reply @shimondoodkin 2 years ago (edited) in my opinion his idea of stressing cells makes sense. not everyone does sports training. stressing cells probably does something. the idea he described is to scare off the cells and make them work like it is a stress now.... it does what he said. but it is an optinion, not, a checked something... you might know better . 1 Reply @iuliavasile3278 1 year ago (edited) It was an unfortunate hurry for resveratrol About the rapamicine study, i hope it shows a very clear result. I have red bad reviews among people with cancer also (though helping them with that), people taking it as antiaging supplement, and i' ve tried it myself - a very messy experience. Even at lowest dose i have got muscle and joint pain, extreme fatigue, low immunity, but worse, depression, lasting up to 3 days at least after each dose. Took it for 1-2 months. In vitro research is just not fitting to humans. There are studies allready explaining that. Reply @SP-ss4uo 2 years ago On thing you have to give Dr Sinclair credit for. He looks damn good for 55. So what ever hes doing is working Reply @jonathankent6877 1 year ago what about if we take resveratrol with nmn? are there so-called synergistic effects which overcome the weakness of these two supplements being assessed separately? Reply @bluenotesoul 2 years ago It doesn’t take long to see that Dr. Sinclair is more concerned with book deals than he is about being honest about the current research 2 Reply @Nobody95008 9 months ago Interesting. Try explaining that to the Greeks Ikaria. They live very long. Red wine was main part of their diet as well as vegan diets and olive oil Reply @jeanphilippegroleau428 2 years ago Stress the cells... isnt stress good sometimes as with exercise ? Are there no benefits in stressing the cells ? Reply @hausgagag4923 2 years ago what about applying resveratrol topically to the skin? Reply @differencebetween6823 4 months ago Dr Sinclair is a pioneer in anti aging research. He looks 20 years younger than his original age. Hey doc, instead what you have to offer for anti aging. Reply @glenesis 6 months ago So shouldn't we be taking the florescent dye? Reply @emittfuller6348 2 years ago Dr Stanfield great video as always. can you please do a fact-checking video on dr Sinclairs claims about partial reprogramming? from what I remember he claims that in his lab using only 3 Yamanaka factors he can reset a mouse epigenome back 80% with no teratomas or cell toxicity but from my basic understanding that has got to be false because other doctors in the field can't even get a pancreas to regenerate without damage Reply @cylack 1 year ago I have observed Sinclair and his research for a while and it seems his financial ties prevent him from seeing things in an unbiased way. I trust scientists who have no financial incentive one way or another. Thanks to your videos I stopped taking Resverator (and NAD) a long time ago. 2 Reply @frontier9142 1 year ago Soooo where can we find that fluorescent dye? 1 Reply @paul715 2 years ago Dr Stanfield. Is it possible to make an online consultation with you? I really want to be one of your patients. 2 Reply 1 reply @Capricorn2024 2 months ago Reputation is everything and to not to give respect to another colleague and the public regarding a supplement is a waste of time and energy to even consider using it 1 Reply @kekoakaawa8879 6 months ago Can you comment on the mouse study for resveratrol? I think there was supplemental info on it that said resveratrol extended a mouses life by 3 years when it was used every other day. 1 Reply @TatooedDoc 7 months ago what do you make of the NAD precursor, nicotinamide riboside? Reply @megan0linscott 2 years ago resveratrol truther lets go 1 Reply @annavieste7208 8 months ago My friend is 96 and when I asked what he eats and does every day … he said he doesn’t eat meat eats a bit of fish but drinks a few glasses of wine every day … I think I’ll stick to a few glasses of wine a day walk eat well etc … 1 Reply @rickstokes2239 2 years ago This being true, what are your opinions then on Sinclair’s research on NMN and NAD+ ? Reply @ryanm9565 2 years ago are there any phytochemical sirt 1 activators that are effective? Reply @YANKTON1000 1 year ago Perhaps they could salvage all of the existing Resveratrol by using it in future medical studies on aging as the Placebo. Reply @lucaskazama878 2 years ago (edited) a long long time ago I put in this channel that dr david sinclair will never come to your channel, because he doesn't go to places to be contraried, and some people started defending him. well, this still applies today. he will not come, and even if he comes, he will dance around the question without actually respond it But I'm really thankful about David Sinclair, because he kind of kickstarted this industry, maybe the wrong way, but no one even cared about it. Before him, it was just people talking about the crazy guy named *Aubrey de Grey*, , as if it was a complete waste of money. But not real progress in the area. And because of him, I met the guy on the couch. :) (I'm missing my spell corrector, sorry) Reply @RJay121 2 years ago Wow. This is a remarkable confirmatory indictment of Sinclair as a snake oil master. I will never trust anything he touches. And that goes for anyone who does the same. I could have seriously injured my body. You saved us all Reply @emreon3160 4 months ago Do you have any GMP sources for the API to start the trials? Reply @kruzanJFD 2 years ago What does that say about the rest of his ideas and research, his book, his use of this personally, and the NMN supplement for example? Reply @southside9417 2 years ago Does ASTAXANTHIN replace vitamin C, E and A.???? 80 year old PLEASE HELP THANKS Reply @davidg.johnson7208 1 year ago I would like to see a comparison of Dr. Brenner's DNA Methylation aging test to Dr. Sinclair's DNA Methylation aging test. Reply @danieltschmitt 11 months ago This is very interesting: A few years back, I tried Resveratrol after I had seen multiple videos of David Sinclair. I immediately felt limited in my exercise performance on days where I took 250mg trans-Resveratrol in the morning. So I stopped taking it. Obviously, this is just an anecdote (and not data) but like the fact that I have some data which supports my subjective feeling. Reply @texastexas4541 1 year ago It worked when I did it and I sold my used car for a huge price. I know it is confusing about misinformation about used cars. I still recommend you to buy a used car that never ran. Reply @ziyaonbashi5864 2 years ago Did you dye your hair? Reply @keith1273 1 year ago (edited) I have ordered prohealth brand NMN . Is it a good brand? Any one knows the background of the company? One of the youtubers introduced Dr Brand Stanfield recommended this brand. Reply 1 reply @Frank-si2jd 2 years ago (edited) Can you also please comment about Sinclair’s claims about Metformin, NMN and Intermittent fasting? Reply @jefb2361 11 months ago So red wine hasn't a longevity effect? Then why is the Mediterranean diet so beneficial? If ithe answer were, say, olive oil, then would omitting Claret further extend lifespan? Reply @RyanK-100 1 year ago Not only are Sinclair's resveratrol studies discredited, the whole InsideTracker project that he backs is called into question. I almost signed up for their Ultimate program a couple hours ago. I'm glad I waited for updated information. Needs more research. Reply @trose9648 2 years ago I’m a bit disappointed that Dr Sinclair has not responded to the newer clinical data. He really needs to do this to stop the confusion. Reply @davidjames5517 2 years ago Best advice on supplements vs shit fight btw two doctors. You get the balance right, but only just. When they aim low and all that! Reply @jaykraft9523 1 year ago Sinclair has been running but he cannot hide. If he wants to be taken seriously, he needs to come clean already. It's gotten ridiculous 1 Reply @natashakramer4411 2 years ago I recently started to take resveratrol should I stop??? Reply @shannonmackenzie7261 2 years ago Do you have info on NMN or Metformen? Reply @johnmartindale592 2 years ago (edited) is it be possible to take a diluted form of the human safe fluorescent dye used in the study to increase the absorbion of the resveratrol, At least until something sles is discovered? Reply @dennyjstudio 2 years ago why not pterostilbene as an alternative? I found res ramps me up. Reply @Bodzio1982 2 years ago Can I take MNM without Resveratrol? I stopped taking my supplements this morning Reply 1 reply @rlunger1 2 years ago I listen to you, thank you. Dr Sinclair seems to have a financial interest and I no longer follow him as that confuses the picture! Reply @frontier9142 1 year ago Soooo where can we find that fluorescent dye? Reply @laurieparis2203 2 years ago Methinks Dr Sinclair has a $720 million problem on his hands, and will say as little as possible on the subject so that he has less to retract later on. That's what lawyers generally advise. Thanks for the video, Dr Brad! Rock on! 2 Reply 1 reply @bataalexander9703 2 years ago What would happen if we just inject directly sirtuin 1? Reply @shanongwynne6439 2 years ago the difference is helping people or controlling who makes large amounts of money, it's very clear which one wins every time in our corrupted society. Reply @Theultrazombiekiller 1 year ago Based on my research, Resveratrol can do wonders. But the key is basically less is more. Instead of consuming a gram of it a day, do 100 MG. That seems to work better. Reply @Leeryannavy 10 months ago Can you do a video on catechins? Reply @RobbsHomemadeLife 2 years ago Can someone do a video on what we know for sure about ways to improve our health and lifespan? Every 5 or 10 years it is something new that we find out later was wrong. I am getting ready to go back to bloodletting, leeches and wearing garlic. Reply @jeremyturn8516 2 years ago Why is “sirtuin” called a gene sometimes and an enzyme other times? Reply @guitawrizt 1 year ago The esteemed Dr. Sinclair is taking on the odor of Snake Oil. Reply @adorableparakeets3608 2 years ago Dr. Brad - now that Dr Sinclair has responded to your video, I would suggest to be patient now, better not be aggressive. After all he is senior to you. Reply @Splassshhh1234 2 years ago Thanks...Im sure it's not comfortable arguing with Dr. Sinclair Reply @murraywebster362 2 years ago More info on Resveratrol "it has shown it can extend lifespan in several lab studies. Resveratrol also demonstrates anti-inflammatory and anticarcinogenic properties, and can lower blood pressure, improve heart health and boost cognition. " Reply @lucaskazama878 2 years ago someone that is a ghost on the internet, and that somehow have a huge contribution to the area, especially when talking about nmn, is Doctor Shin-ichiro Imai , and almost no one interview him. Reply @young-forever-nmn 2 years ago What is the truth? Is NMN still better than NR? Reply @alistairproductions 2 years ago What's the fluorescent dye Reply @oakisland9 1 year ago (edited) is there any positive research evidence saying that resveratrol, Pterostilbene grapeseed extract has any promising benefits other than NOT increasing lifespan like for these supplements to supporting the cardiovascular system, brain health in anyway? Reply @charliecleanup 1 year ago thank you good video...really wondering about why not respond...very odd Reply @ahf5471 1 year ago I should have asked Dr Sinclair when I was standing in line by him and his family on NYE 2022 at Animal Kingdom on the Dinosaur ride…. Reply @wd-id4th 1 year ago Is there any evidence of harm caused if following Sinclairs advice? I read his book and bought into the hype around NMN and Resvertrol. ️ Reply @falconone7230 2 years ago He made his life based around his work and if you watch his videos about resveratrol,he'll explain everything Reply @JohnnyMagorish 2 years ago (edited) I listened to David Sinclair’s new podcast. A question came up around the health benefits of red wine. David said it’s probably due to the resveratrol, to which his co-host pointed out that the quantities are negligible, to which David said it’s probably due to other flavinoids. It’s well known that red wine does not contain enough resveratrol to have any effect, so why would he even say this. Reply @alexlangevin8340 2 years ago Just invite him for a discussion on the topic 1 Reply @Boycott_for_Occupied_Palestine 2 years ago Beautiful. 1 Reply @iggytse 1 month ago About 10 years ago I tried resveratrol and I felt worse. This all makes sense now. Reply @daboxingscholar 2 years ago Love you channel but 3:43 you read lol like a super computer Reply @scottk1525 2 years ago Keep at it! Maybe if we all chip in and start nagging him on Twitter, he'll stop being so passive aggressive and respond with something of substance. Reply @remymay3632 2 years ago Dr. David Sinclair mentioned on the Huberman Podcast: no life extension in mice fed daily with Resveratrol, but life extension in mice fed every other day with Resveratrol. Is this true? Reply @GregGupton 2 years ago If the mechanism of action for resveratrol is discredited, then what about alternatives to resveratrol? In Dr Stanfield's video https://youtu.be/PmoV9O8xHWg he highlights Pterostilbene as being far more bio-available. But does Pterostilbene have the same mechanism of action as the (now discredited) resveratrol? So is Pterostilbene now, discredited too?!? Reply @joemurray8902 2 years ago Excellent job. I love Dr Sinclair but that doesn't mean I'm a slave to everything he says. If the data is questionable then it needs to be addressed. 1 Reply 1 reply @disruptapps 1 month ago Well, where can I buy that fluorescent dye? LOL Reply @TheJpepe21 2 years ago I will keep using my resveratrol for now Reply @smallfootprint2961 2 years ago What I think about the whole thing is eat a great whole food, plants only diet, and you won't need supplements. B12, and D3 may be the exceptions. Taking concentrated supplements may do more harm than good. Reply @mohammedabdulla4028 9 months ago Thank you for confronting one of the field’s biggest frauds. He is now a discredited snake oil salesman. You have in the past talked positively about the subject but reversed your opinion once data evidence showed otherwise. Respect. Reply @jefferyjeffery1707 2 years ago Well....I read the original papers.....and it was always flawed at the start. That you could isolate resverstrol by itself into a supplement....and have it increase longevity. Because resverstrol had to work in combination with other compounds, to be effective. Reply @neurotraveller 2 years ago I would like a discussion between you and Bill Sardi a major Resveratrol promoter. Reply @thoth111 2 years ago The worst thing about all this is that it will have a terrible chilling effect on future research. No university or corporation is going to touch 'longevity' compounds after this debacle.... Reply @rfbead321 2 years ago I am not a parishioner at the church of david sinclair 2 Reply @franshartman4378 2 years ago Dr Sinclair clearly has financial incentive to market resveratrol. Reply @lakeocean985 11 months ago I wish Dr. David Sinclair is not another Elizabeth Holmes 1 Reply @paulfiedler9128 2 years ago I went on his YouTube channel---of which I'm a subscriber and told him he'd better respond to you because you were "kicking his ass" by revealing that he lied about not knowing the ineffectiveness of resveratrol. I'm not happy about this. Sinclair did a recent interview where he was recommending taking a gram of resveratrol a day. I had been taking about 1/2 a gram but after that video, I went and purchased a lot more resveratrol and now I feel foolish. Reply @perrypelican9476 2 years ago Sinclair appears very credible as do you. I hope he does the right thing and talks to you. If he doesn't, it might be because he is afraid to lose credibility. If he waits too long, he will look very foolish. Don't give up. Stick to your beliefs. Just don't get too aggressive. I will keep checking because this is just too important. This is the age of success through dishonesty so we never know what's really going on. I have to cut back on carbs and sugar if I want to live longer than I am headed. Any advice, because I'm having a hard time controlling my diet. I take a statin for cholesterol and telmisartan for high BP. Reply @nbrown6648 2 years ago (edited) Good job. David Sinclair is a smart fellow and his lab does some excellent work in the ageing field, but in my humble opinion, his optimism and desire to be influential (at which he is very successful, sometimes too much so) clouds his objectivity in some areas. It should be David himself openly saying "my original work on Resveratrol could not be corroborated, I got this or that aspect wrong", and then move on to talk of other avenues of ageing research (which he does with excellence). But how do you say "I was wrong", after receiving awards and hundreds of millions of dollars stemming from that very result ? Reply 1 reply @manjunathaa.m9242 8 months ago I've been taking NMN (1g) and trans-resveratrol (500mg) supplements for 6 months, and I've noticed increased hair loss. My hair is thinning, and my scalp is showing. If I stop taking these supplements, I notice that the hair fall halts. possible link between resveratrol, cell stress, and hair loss. They are implying that if resveratrol does indeed stress cells, it could be a contributing factor to hair loss. Has anyone experienced this? Any advice? Reply @marycarlson2874 2 years ago Is there research on nmn? Reply @gaston. 2 years ago the more I learn about this field the more I realize there is no room for any arrogance or thinking we are making huge breakthroughs. Michael Pollans views seem to ring true.. enjoy life, eat food, mostly vegetables. Take this all with a grain of salt and don't be manipulated out of your hard earned money. Reply @LeanneWashington-jq5df 7 months ago Dr. Sinclair states he never endorses anything wow what a lie I’ll be sending my order straight back to Amazon. Thank you. Reply @markocroatia1 1 year ago So what was the dye??? Reply @friederichrex9622 2 years ago This is why i really don't like taking new things. I'd just rather take tonic herbs with ancient experience, tried and true, for my longevity stack. Reply @panteleymonschekochikhin-k1978 1 year ago Now how do i buy that dye Reply @lk6424 2 years ago I would love to be part of your Rapamycine study if is possible. 1 Reply 1 reply @pierrejeanes 1 year ago The real question is why take the made in laboratory resveratrol, when we could est some blueberries ?? Whyy i just don't get it Reply @AS-gx4qg 2 years ago I have stopped taking resveratrol. At least for now... Thanks. Reply @sw99up 2 years ago In Sinclair's appearance on the Huberman Lab podcast a few months ago, Sinclair actually said something along the lines of: If scientists lie, they burst into flames because they will always be found out by their peers (that was the exact metaphor he used, I believe). It sounded off when he said it and it sounds even stranger in light of everything you've highlighted. And disappointing that Huberman did not vet the resveratrol stuff properly for that podcast. Reply 1 reply @frankasafscimone3920 2 years ago (edited) Dr Brad Stanfield is doing the same thing he says Dr David Sinclair is doing. I asked him a very poignant question and he has not replied. I have seen many of Sinclair's videos and he always says to take resveratrol in conjunction with fat - such as olive oil, for absorption - and NMN. I have been doing this, as have many others, and there are amazing results. I have never heard Sinclair say to just take resveratrol. Stanford seems a bit young for anti-ageing supplements anyway. 1 Reply Dr Brad Stanfield · 2 replies @dantalbot1201 2 years ago Dr Stanfield many of us can see the sinclair is full of it! Reply @HCW2855HCW 2 years ago Maybe I should take fluorescent dye for longevity! :) Reply @swisstrader 2 years ago Never understood why GSK had to pay for the company. Isn’t the basic ingredient in resveratrol simply grapes which isn’t exactly a proprietary formula. Reply @MissesWitch 10 months ago I listened to David Sinclair about Resveratrol and even bought it, but after a few tries and getting chest pains each time, I thought it's just not for me. Then I saw your video and thought.. wait what, really? Then thought maybe David Sinclair had done experiments using only Resveratrol on rats..? But I guess not.. I hope he had more reasons for what he said. Because if he didn't, It would be really damaging for his reputation/reliability. Reply @alexribeno1612 1 year ago I have posted several times over the last 15 years about Sinclair. I have followed his research since the early 2000s and have found less than transparent about his research. Many times his statements are conflicting. Sometimes he states that he supplements certain compounds daily and certain amounts and at other times his protocols are very different. He comes across highly commercial and I do not rely on anything he says which many times conflicts with research data and opinions of many professionals. I wish GSK took the matter to court so we can expose the truth. Reply @JerzyFeliksKlein 1 year ago I don't really trust somebody who measures the strength of his arguments by the number of likes on Twitter... 1 Reply @timsiedem9030 9 months ago So why would Sinclair still be endorsing resveratrol today ? Certainly he wouldn’t be taking it himself he would be well aware of the flawed research . Speaking of which did GSK file a lawsuit? Great post btw I was just going to buy some resveratrol. Reply @ConnoisseurOfExistence 2 years ago I really wonder though, why the researcher who did consult Dr Sinclair about his research, did not actually try giving the resveratrol to the mice with fatty food... 1 Reply 2 replies @AnnO-qk8ep 9 months ago Sinclair takes these supplements, which is enough for me to follow. Reply @christopherellis2663 2 years ago (edited) He had many YouTube comments requesting that he do so. meanwhile, I will stick with unpeeled grapes Reply @desaparecidagataentorrevie9800 1 year ago SILENCE SPEAKS...when you don't understand the terms and there are two doctors talking about non-aging... I see Doctor Sinclair who is over 50 years old, he seems 25 years old!!! And Doctor Brad Stanfield, who tells us difficult stories. But just seeing his person without understanding anything of the story he explains... he looks more stressed, and he looks older than Dr Sinclair... seeing this it is not difficult to understand which ambassador could be right! Reply @gettin-stuffdunn6028 2 years ago Dispassionate, evidence-based science can be tough to swallow and ego-humbling, but it is required to advance. 1 Reply @gerardt3284 2 years ago lol. My respect for him just plummeted. Reply @auriellenazro2516 1 year ago (edited) Hmmmm I value Dr Sinclair s research as well as Dr Kirkland and yours of course. I expect disagreements between scientists- for that is how more testing comes about in the search for real scientific discoveries. I do wish that a bit more finesse upon your disagreements with Sinclair… let’s focus all disagreements on the science and not on the scientist instead. Communication is essential with all parties involved in this very important field. Reply @MusixPro4u 2 years ago (edited) Regarding your rapamycin trial. There's a lot going on in the crypto industry regarding new funding models (and a lot of capital waiting to be deployed). Not just VitaDAO. If you search for the keywords "DeSci" or "decentralized science web3", the relevant projects should pop up. You can also respond to this comment if you have any specific questions. I'm active in this space. Reply @thefruit 2 years ago Hi, why are you expecting him to make a statement just because you made a Youtube video? Also why do you point out that your specific reply to a tweet has more likes than his? That seems unprofessional, childish and as if you just want a lot of views on your next video. why dont you just talk about the scientific evidence? Trash talking and Science doesnt go well together. Maybe make a seperate video and put it in the title. 3 Reply @eva9110 2 years ago What about salvestrol? Reply @ianokay 1 year ago Should we just be eating the dye they used instead? 1 Reply @ritsukohairsalon 1 year ago What abou metformin? Reply @michaelansari2222 2 years ago Credible , transparency is the gold standards . Hope Dr Sinclair realizes there are millions of peaple who are taking resveratrol. speak publicly and debate your finding. 2 Reply @TipuSultan-nb3od 2 years ago Anything to do with Harvard? Reply @libertycowboy2495 2 years ago Science is about constant experimentation and questions, not consensus. Reply @CannabisRex 2 years ago Like other comments below (See Levon Darratt's reply to Consuelo Campbell) I wonder how and if Sinclair profited off the sale to GSK? Aren't academic researchers bound to give such proceeds to the institutions they work for? Is there some kind of profit-sharing agreement between them and their employers? There certainly would be if they worked for private corporations. Reply 1 reply @davidcarljones7565 2 years ago I listen to his podcast, it’s hard to understand why he still takes resveratrol if the latest papers debunk it’s uses Reply @ewancorlis4042 2 years ago There might be lots more compelling data on resveretrol it cant be condemned just yet surely.It has been used for years now * in conjunction also.Science is good. 1 Reply @SawmillerSmith 2 years ago My opinion as you presented it makes it appear he is dodging your question. Reply @TheNebuloza 9 months ago First off, I want to say that I didn't check the original research myself and therefore do not subscribe to either opinion. That being said, this video does seem to fill a gap in scientific communal management - it creates a direct link between published research and its rebuttal, and tackles the issue of fame and the associated access to public opinion which sways the direction of scientific research in terms of funding, I think it would contribute to the apparent purpose of this video if the link to the original research were in the description. Reply @Solingen1000 2 years ago Medical drama. lets go! 1 Reply @clacclackerson3678 3 months ago Money changes everything. Reply @michaelhall2138 7 months ago (edited) I don’t believe SKB would write off $700 million dollars without some legal recourse. What did they do? This was 10 yrs ago folks. Reply @dennisbauer3315 2 years ago Best available data.........At the time. Reply @franknielsen2910 2 years ago just go on - follow the tue I like you brightness Frank from Denmark Reply @danpictish5457 2 years ago You're a star Dr Brad. I'm afraid Dr Sinclair may have a financial connection to Resveratrol. Reply @MrSaxxie2 2 years ago Dr. Sinclair also continues to push NMN while you have shown that NR has the most positive human trial results! What does one do here? 1 Reply 1 reply @claudiaisabelgaldames9539 1 month ago Hi, hiw old are you? I am 56 and people including doctors say i look 37 or max 40, that means what i do is correct, in other words my question goes to see if i can trust what you say. Thanks Reply @Draziell 2 years ago You have almost 100k of followers... If Sinclair agrees to debate this, it would help almost 100.000 people to make their choice... I don't understand why he doesn't do this. 1 Reply 1 reply @annmariewilliams4534 2 years ago I still not sure don't understand what he is trying tell .. Reply @RafaelVasquezUnelectric 1 year ago Controversy finally explained here ... @ Reply @scottgurney2659 1 month ago Sinclair better respond or he's gonna find himself with a class action lawsuit Reply @NMNAntiAge 2 years ago We want to hear more data specifications, especially since we want to launch a high-quality trans-resveratrol and are considering investing in TMG production. Indeed, all of this isn't very clear at this stage. We hope Dr Brad and Dr David can have a proper conversation any time soon. We are wishing both doctors keep doing a fantastic job in their discoveries. We want to believe that it's not the money that wins but integrity and the overall mission at the end of the day. 2 Reply 6 replies @coreysievers 2 years ago I was not impressed with Dr Sinclair after an early interview where he indicated he personally implemented little of the many other 'tactics and tools' regarding longevity and life extension. His book indicated that he wanted to 'medicalize' aging and label it a disease. That leads to certain treatments being the only 'approved method' for that disease. In light of the current situation, Cancer,. Heart Disease etc - I DO NOT believe that aging should be considered a disease (though pharmaceutical companies would disagree!) Reply @mooinabc1 2 years ago May its Resveratrol senloytic. If Resveratrol was proven in different labs which it did not this is fact. But moving no to better things is key to being successfull. Reply @johnbielenda7336 2 years ago wow..........i did not know of the sell out......... Reply @felipeherrerasalinas9488 2 years ago Resveratrol antagonizes TLR1 (blocking post prandial vascular inflammatory responses), so maybe this is a factor in resveratrol rich diets. Reply @tyski9000 8 months ago So where do i buy the fluorescent dye? Reply @andremenezesgroff2818 2 years ago Who’s gonna stop this guy? Reply @sidneyfyfe7142 1 month ago Doesn’t the crspr technology have a vested interest in discrediting all natural cheap remedies?? Reply @CJWass09 2 years ago I'd only use pterostilbene Reply @StephenCoda 1 month ago I took that stuff a long time ago as I thought it'd help with my ability to stay awake during the day. It irritated my eyes so much they were like peeled plums, this effect went away when I stopped so the relationship was obvious. Later discovered it's a stilbene and is rather estrogenic. Stupid stuff. Reply @UHFStation1 1 year ago It merely sounds like he didn't address you in particular. Doesn't make him wrong. Reply @tucsonastro7763 2 years ago Dr. Stanfield....Did you really think that Resveratrol would increase your longevity????? Thanks, James Reply @mrpmac 2 years ago David Sinclair is a god among men, who has pushed longevity talk into mainstream. Maybe Resveratrol, maybe not. * shrug * May David live forever. (pun intended) 1 Reply 2 replies @uncertainparticle4132 2 years ago Every time I see ldl rise I assume there’s a rise in inflammation of the body and the ldl is a response of the body to repair. Reply @gabymalembe 2 years ago I think Sinclair would be foolish to debate you because you give the impression that you think he’s a scammer who misleads people about the research, and you want to expose him. I do appreciate about both of you that you change your minds every few months when you get new information. Reply @RecoveringDegen777 8 months ago WEEK RESPONSE, SIGNS OF GUILT! CLEARLY! Reply @enkibumbu 1 year ago Wow. You're very credible. I'm going to dump my expensive bottles of resveratrol. Reply @swisstrader 2 years ago Why is Sinclair referring to a study from almost 20 years ago? If resveratrol is so effective, why are there not more recent studies? Reply @Zsaqwes8 2 years ago What a sellout. If hes stuck because of legal reasons he should have just kept quiet and not contribute to spreading misinformation AND slandering someone who is actually putting the truth out there. Really disappointing 2 Reply @omarino99 2 years ago ratio’d Reply @seaweed167 1 month ago what about nmn and nac ? Reply @droidgracie4121 2 years ago There are 720 million reasons why David Sinclair will continue to champion resveratrol and thus avoid directly responding to Dr Brad. Reply @nikolasbbq 1 year ago way to go GSK - it was ONLY 750 million for NOTHING! Reply @raychance9016 2 years ago Thank you for the latest "data point". Sinclair < .00000001. Reply @EamonnOConnell 2 years ago It's hard to know where the truth lies. Was it in the Wire they said: it's all the game? Reply @basfinnis 2 years ago I think a fight to the death is called for Reply @threeone6012 2 years ago After watching this video my position on David Sinclair, which was already wavering fell further. Reply @barkmaker 2 years ago His lack of response is telling. I will not be wasting my money on resveratrol. Reply @rudarmax 2 years ago Is this fella real or computer generated image? Reply @IvaneJ 2 years ago Are you saying he initially said that masks don’t work but then changed it? Reply @GizmoFromPizmo 1 year ago He's kind of doing what you do with Vitamin E Tocotrienol. Your reports use old data on (mostly) alpha-tocopherols. I would like to here what you find after looking at Dr. Barrie Tan's research. Reply @jayb8056 1 year ago Apparently Sinclairs lab also had many failed experiments but only published those that were successful - and those were in the minority. Reply @chriscullen1291 2 years ago It goes to show how business and science (or truth) can hinder eachother sometimes :p Reply @sgwbutcher 2 years ago At first glance, this seems like a classic case of what's wrong with Frequentist statistics and its effects on research. Because of Null Hypothesis Significance Testing (NHST) and silly nulls (assuming NO effect at all), there is a bias towards publishing "statistical significant" (and therefore large) effects but large effects are just more likely to be outliers. Many fields, including medicine, psychiatry, computer science, you name it, are experiencing a "reproducibility crisis". For example, "The Bayer scientists tried to validate published data for 67 projects, in the fields of cancer biology, women’s health, and cardiovascular diseases []. Of these, 43 (or 64%) produced results that were inconsistent with what was published (Figure 1). " to name foray into this issue. And I know very, very few medical researchers (actually any researchers) who have statistically savvy enough to even know what a p-value actually is or means or a 95% confidence interval. However, I do really applaud the field's attempts at reproducibility and randomized controlled trials. It just doesn't excuse all the statistical sins. Many of these science publicizers seem pretty oblivious to the statistical crisis and seem to take statistical significance at face value. (And based on the latest findings on metabolism, we should be a lot more critical of mice models.) Reply @andrewb5004 2 years ago Bazinga Reply @xoxoxoxo5224 2 years ago HEH. You're all so petty, love it. Obviously the human frog has gotten one over on the human crocodile. 1 Reply @0544303395 2 years ago what is the old idea behind the franch people are healty because they drink red wine ???? Reply @boomerz2478 2 years ago Does he have any legal culpability in relation to GSK for essentially selling them bad research and data? Perhaps this is why he’s doubling down on it because if he admits his own method was flawed then it may open him up to claims of fraud. Reply @FulvioGa 3 months ago So, I have thrown my resveratrol supplement capsules in the bin: a waste of 22 €. But luckily I ate only 19 100 mg capsules of the 90 that I bought. I took last one just this morning. Reply @phytopanacea 2 years ago Dr. Brad, I know this is a very controversial topic, but I would love for you to look into Dr. Stefan Lanka (PhD virologist), Dr. Andrew Kaufman (MIT Scientist), and Dr. Tom Cowan's (Duke MD, Summa Cum Laude) work on the pseudoscience of virology. When you spoke of dye's giving a false impression in the study, it reminded me of this as these three men have diligently exposed the anti-scientific standards of the field of virology and what "virus isolation" actually is. We need super smart people with an audience such as yourself promoting truth, and the truth about virology would shock a lot of people. Basically, "viruses" have never been shown to exist, cannot be identified nor extracted directly from the bodily fluids of any animal or living being, so they must perform pseudoscientific cell culture experiments that have no control group (except for Dr. Stefan Lanka's experiments), and no basis in reality. They mix the mucus from someone who is exhibiting signs of illness, assume that the reason they must be exhibiting these symptoms is due to a virus, then mix that patient's mucus with cytotoxic antibiotics, fetal bovine serum, and then starve the cell (which is either a monkey kidney cell or aborted fetal cell) of nutrients... Observe it and watch it die. Then they take images of the dead cell fragments from the aforementioned monkey kidney cell or aborted fetal cell and call them "viruses". In reality, they are cellular debris and the cells died because they were poisoned and starved of nutrients. PLEASE research "virus isolation"; this is exactly how they conduct these experiments and it is totally pseudoscientific, avoids the scientific method at all costs. Some will use the excuse of "viruses are too small", but that is simply not true because we can isolate, purify and extract compounds which are smaller directly from the bodily fluids of a living being, such as exosomes and bacteriophages. Thank you and I enjoy your videos. Reply @richdb1115 2 years ago David Sinclair turns 53 in June and his appearance speaks for itself ... Reply 1 reply @abvmoose87 6 months ago Ok hold on now just a minute, that resveratrol doesnt increase Sirtuin activity was new to me but are you saying that upregulating sirtuin enzymes a bit for keeping cellular metabolism in a better state doesnt render health benefits? Im pretty sure they do and theyres plenty of studies to proove that. His reasearch company was bought by GSK for the STACs candidate theyve found and do increase sirtuin activity significantly. They were effective in GSKs trials if you take the time to actually read them an not just glance the headlines. But you got to wonder if a big pharma company wants to release a medecine that works on such a fundamental cellular level in improving metabolism and boosting repairing DNA damage. They intentionslly botched the 2nd or 3rd clinical trials by moving the goal post so it would just fall below the marker of what constituted statistically significant. So now they got an excuse not to release it as an official drug and its locked away from the public for another 20 years or so due to them owning the patent. And this isnt the first time this had been done. They dont want drugs who just boost overall health and can prevent several diseases from forming. There are other examples of drugs who never were released and fell short in the last clinical trial on a technicality but we know are great candidates. I know about the argument of resveratrol having an inhibiting effect on recory from exercise which is a given if you study tve biological pathways it interscts with but the solution to that is to time as far apart from the time you exercise. Whats your point? I think youre saying not to take resveratrol cause one study says it doesnt raise sirtuins? Which sounds strange to me but ok. Are you also saying that raising sirtuin expression dont have health benefits? Are you saying the STAC candidates from Sinclairs former company doesnt raise Sirtuin expression significantly or are you just drawing a conclusion that tvey dont have vast health benefits just because Gsk intentionally botched their 2 or 3rd clinical trial of their most promising STAC candidate? Reply @boontheamho4220 2 years ago You are the only person who is now opening attacking David Sinclair... relentlessly and non stop...he does research but you read research.. both are doctors. 1 Reply @vincentcwli1 2 years ago Some people get 720M and some people get fired. GSK shows they make mistakes. Reply @Spence. 10 months ago What about nmn Reply @homeontherange733 11 months ago Another one bites the dust:( Reply @inquisitor4635 2 years ago (edited) So this guy Sinclair is the 720 million dollar "Theranos" of the supplement world. 1 Reply @TheBruceKeller 2 years ago The studies on monkeys and rats still seem pretty promising; some of them being after 2009. Stinks for simpler organisms that it doesn't seem to work too well for them. Mammals maybe lucked out though. Reply @BizAutomation4U 2 years ago I used to respect Dr Sinclair, because to the naked ear, watching videos and interviews he seemed so genuine, and his "Woe is me" stories about how big-pharma unfairly targeted his lab for commercial gain in the mid 2000s (spending time at home depressed for 2 weeks, becuase all his researchers leaving his lab at Harvard, yada yada, and being vindicated later). It's only when they're backed into a corner that one can actually prove their true mettle. We get very few chances to see someone for who they really are, and I'm very saddaned to learn Dr Sinclair doesn't appear to be who I thought he was. Is there any other way to look at it ? I don't want to be too harsh, but I don't want to be a fool either. This puts everything else into question, and unfortunately to us lay people, we don't have the expertise to seperate what might be legit from what isn't. Guess that's what happens when you loose one's trust. Reply @whittlejoe 2 years ago There is a train, but it’s not the Resveratrol train, it’s the linoleic acid train! Reply @jenxsj3902 1 year ago I am so angry. I just bought 4 bottles of Resveratrol. Will dump the whole lot on the bin. 1 Reply @lightgearwire 2 years ago Get your NAD levels up EXERCISE.......... ️️️ Reply @genesmolko8113 2 years ago Disappointing, what a shame. I read on Reddit that Dr Sinclair called your analysis "horseshit." If that's true, that's very disappointing, an insult instead of a substantive response speaks volumes. This would not be the first time I've seen him respond this way to criticism. A scientist who can't accept when he's wrong is not much of a scientist. 2 Reply Dr Brad Stanfield · 15 replies @trentriver 2 years ago (edited) This is not the first time nor the last when scientific conclusions got ahead of bonafide facts ... happens far too frequently. 1 Reply @jcgmba98 2 years ago Another example of how we all can learn just as much about how to act, what to do, what not to do from those who act poorly (Sinclair) as we can from those who do / say the right things (you). Sad. Sinclair is just too dug in. I guess we can thank him for bringing the larger topic of longevity expression strategies to popularity even if his methods have proven disappointing. Reply @stephenmurray2851 2 years ago Jesus christ why can't I just get a simple answer. What do I take to make me look much more youthful? Reply @DixieGeezer 2 years ago (edited) Is this going to be another Theranos, Elizabeth Holmes case? Reply @Haharino 1 month ago You both should put on boxing gloves and get it sorted in an improvised cage ring ... Reply @CraigHocker 2 years ago LOL. At least that’s slightly better than the turd emoji reply he gave previously to your Twitter comment on the CRISPR paper. Having looked at the more recent papers. I’m not confused either. That’s a pretty pathetic response to reply with the 2006 paper. I’ve been skeptical of Sinclair’s promotional boosterism for a while but it’s going to a new low. Keep up the good work. Longevity field needs lots of healthy skepticism. Reply @Lennythewinner 2 years ago The best way to extend lifespan is stay as bored as possible. You may not actually live to 120, but it'll sure feel like it. Reply @MaxMaxMax3 5 months ago Misleading title. Dr. Sinclair has not responded to you. I guess he never saw your video and was just answering in general. Reply @waynewells2862 2 years ago Let us hope that there is a "Baby" in the bathwater of David Sinclair's research. I have David's Book "Life Span" and was inspired by his worthy vision, however I am going to suspend my taking Resveratrol and keep watching the accumulation of data. Much deserved praise to Brad Stanfield for sticking to evidence based medicine as apposed to charisma based medicine. 1 Reply @8803surri 2 years ago Oh i thought he actually replied....keep hassling him to get on Reply @phlevel1 2 years ago So what's the point? Reply 2 replies @MaxMaxMax3 5 months ago A date of a study doesn't say anything about it. You could have said what the 2006 study was missing instead. Reply @allairelagrone6783 1 year ago The title of your video is misleading. Considering he has not replied Reply @chrystale888 11 months ago (edited) I don't know Dr Stanfield, wine is everywhere in the bible as being good for you, but not in excess. On this basis I think Sinclair might be right only research and science hasn't found the real benefits of the grape yet, but G-d knows and made mention of it many times in His book. 'It is the glory of God to conceal a matter and the glory of kings to search it out.' Proverbs 25:2 Reply @snave59 1 year ago LOL means Laugh out loud. Reply @AwesomeBrotherChun 1 year ago the fact that sinclair doesn't even know nitty gritty about nmn already tells a lot Reply @gracewhite1601 1 year ago I eat clean, think clean but do take lots of supplements….that work Reply @tracymullane8818 7 months ago (edited) What do I think of Dr. Sinclair's response? It's a non-response and I don't like it. It speaks to his level of integrity. 1 Reply 1 reply @missunique65 2 years ago (edited) Tsk tsk, How dare you expose the great Sinclair? (aka "botox boy"!) lol. He obviously doesn't like being challenged - why does he appear on EVERY youtube video 24/7 ad nauseum saying the same thing over and over. has he borrowed a page off the media drill if you say stuff often enough, will they think it's the truth and not question it Bless you for doing this -cheers! you rock, mad respect!!! Reply @mickmickymick6927 2 years ago Very dissapointing response by Dr. Sinclair. I have often seen people use a single paper to argue a point, ignoring other, often multiple, papers which might be better done and refute that point. It smacks as extremely dishonest, verging on pseudoscience, from Dr. Sinclair. This is why context is so important rather than single papers, and why I'm glad Dr. Stanfield provides excellent context on this topic. Reply @gordonalexander4843 2 years ago Hi Dr. Stanfield. The following opinion of mine based on what I believe I'm actually seeing here, is not to offend you or anyone for that matter. It is my humble and honest opinion. I think that Dr. Sinclair has offended you in the past by a number of ways. The fact that he declines your invitations to be interviewed by you, and that he has also referred to your past comments as "horse shite", is making you pursue this resveratrol controversy and eagerness like a dog with a bone, to get back at him, and what better way than attempts to discredit him. That being said, I think that he should have accepted at least one of your invitations irrespective of any animosity he may be harbouring or whether he may feel you're beneath him. I can't speak for him, so am just speculating. Albeit, any vendetta aside, it is a good thing to pursue truth and facts and be persistent about it. Science is meant to be debated like it is allowed on this platform and others except if it is anything Covid inoculations negative, in which case it is censored. At the end of the day as just 1 person in many, following the western longevity field, I too want the facts on particularly this hot resveratrol topic, and despite being a fan of Dr. Sinclair's as well as yours by the way, I would prefer to see Dr. Sinclair just finally admit one day, if indeed he got it wrong on resveratrol. But I suspect pride and stubbornness would get in the way as it does in human nature, just like pursuits of vengeance lol. Not to mention, if there would ensue destroyed carreers and or law suits, like there have been. 1 Reply 2 replies @Vamavid 2 years ago I thought they were the same guy! Reply @camcorp 2 years ago wonder if GSK can get a $720 million dollar refund. Reply Dr Brad Stanfield · 1 reply @coswizranancestral845 3 months ago you are wrong, DOES NOT MATTER WHAT THE MANY PEOPLE OR DR SAY, .. I am taking resveratrol and I can see the beneficies, i have 62 and i feel like 30... before, i can not walk for long time, now i run same or more than my atletic son with 25 years old, my exercises are basic, no strong and only for 10 to 15 minutes in the morning, .. I do very soft exercises, my experience is directly, .. nobody can convence me the oposit.. additionaly i am taking 1 mg AKG.. Reply @FHer-kb7gb 2 years ago Why is your skin so shiny? Reply 2 replies @Boycott_for_Occupied_Palestine 2 years ago Dr. David Sinclair is frightened of you Dr. Stanfield. 2 Reply @JA-mn1en 2 years ago Sinclair simply proved he is a snakeoil salesman Reply @royzlatanestevez9843 2 years ago I am disappointed that Dr. Sinclair would forego the opportunity to correct the misconceptions around resveratrol. Possibly he doesn't realize how serious the allegations against resveratrol have become now. He is a busy man. I really hope he finds the time for a proper reaction. Reply 1 reply @JR-ht2vy 2 years ago He’s probably worried about the money! Follow the money! Reply @StanWatt. 2 years ago If money and ego massaging were taken into factor, we would immediately see the BS that they spout, adding to any confusion. Reply @scooterboy2284 2 years ago Dr. Sinclair will never go on your show because he knows you will force him to answer the questions he will not want to answer . Reply @untio 15 hours ago It's incredible how disappointing has been for me David. And now what about nmn?? I think he has made good, but now, I don't know what to believe and what not from him. Reply @SirRakal 2 years ago You'd better not mention like count Reply @carolfox4454 2 years ago Decade old news that was delt with back then. Reply @stevemaximus9046 2 years ago Sinclair on his IG account advises a multitude of disproven health facts. He says to restrict salt. Nope. The sweet spot for all cause mortality is twice the AHA recommendation. He says to limit protein and especially meat. Sarcopenia is directly related to death. It never ends with this grifter. 1 Reply @H1TMANactual 2 years ago I hate resveratrol. It gave me terrible side effects Reply 4 replies @RecoveringDegen777 8 months ago Same thing Vivek Rams did! Reply @jammin6816 1 year ago Money makes a bad scientist Reply @alienblue9543 1 year ago I think Dr. Sinclair might have cashed that check too soon. Reply @Earwaxfire909 2 years ago Seems tragic. I think we know what's going on. Let's not beat a dead horse. Reply @cryptscendence3421 2 years ago Red wine Reply @sofianehamama7073 2 years ago Things can get really murky when big egos and money get in the way of science. The way Dr. Sinclair speaks when interviewed seem to come from an ego boosting place instead of an unbiased nuanced approach. 1 Reply @dudeistpreist5721 2 years ago I forget what he takes but apparently he doesn't take it the days he works outs because it stresses mitochondria. Might be revestrol. Reply @edvedder7835 2 years ago Dr Sinclair and Resveratrol=Hocus Pocus. Reply @RJay121 2 years ago One more thing. WHY hasn't Harvard investigated Sinclair at this point because? Maybe because they got a piece of the $720 mil? OMG Reply @cynicald380 2 years ago (edited) Hi mate. I'm a new subscriber and enjoying your content. May I suggest as a new fan that you change your video pic thumbnail of.. You? I think maybe you wear contact lenses and that particular shot you are a bit bloodshot and are grinning like a Cheshire cat. You are a very handsome dude but I don't think it's a great pic of you.. It would make the difference having a better thumbnail. Maybe your lovely wife can help you get a new pic? I'm sorry I don't mean to be rude. I'm trying to be honest and I mean it well Reply @milanpintar 2 years ago (edited) I've noticed for years that Sinclair is dodgy just pushing his failed hypothesis as hard as he can, it's great to see the science community is onto it. I've tried resveratrol (aka Trol) and NMN with zero results. Reply @thomasackley2532 2 years ago I think Dr. Sinclair's response was a knee jerk reaction to what he deemed as criticism and that no response would've been more considerate of him than to "dis" your work and give a slipshod answer to the person asking the question and the audience wanting info. He's a famous man and after while fame breeds arrogance. I wish he'd have displayed more class. Reply @lawdogwales5921 2 years ago Gutsy move, calling out Sinclair. 1 Reply @soy_titooo 1 year ago The first time I saw an interview from Sinclair I had a feeling that he was a bit of an snake oil seller. I'm not doctor or scientist but that was my feeling. Sadly it seems I was right Reply @sugarcan1110 1 year ago Causes autophagy wat is the problem. We got resveratrol in the cell anyway Reply @privard89 2 years ago I wonder if Sinclair was never honest in this. There has to be a huge incentive to tweak studies if you've already invested insane amounts of time, your money and many investors money. The fear of failure, losing out on a once in a lifetime chance to become ridiculously wealthy and having to admit to yourself and investors that it was all for nothing would make many people trade in their integrity. Reply @michaelschall9619 2 years ago Dr. Sinclair is practicing Duck and Cover. Reply @Augustus.73. 11 months ago Dr Sinclair is clearly a (though admittedly subtle and covert) narcissist. That much is evident upon any closer inspection. (Fron social networks and his body of work alone.) That said, I was hardly surprised to discover certain details going through his biography. On the other hand, Dr Stanfield strikes me as a great guy (we are roughly of the same age) and I gladly subscribe to his Youtube channel and look forward to his future work. Reply @billsalm9196 2 years ago We have engineered very healthy and long lived mice Reply @marktapley7571 1 year ago The only thing Sinclair is enhancing is his investment accounts. Reply @cubalkan 2 years ago (edited) Thats how it is if a scientist leaves his scientific path and search for truth and becomes a business man.... always follow the money if you dont know the facts.. Reply @GM4ThePeople 2 years ago Sinky tells me to eat the dust, I eat the dust. He says, "read my book", I read the book. Buy the stock? I would, but I'm shy about 719.99M. But it'd be nice if he would address newer criticisms he hasn't already; otherwise it looks like he's just been yeastily cheekblasted, by a firebrand of a young Enn Zedder, no less. ;-) 1 Reply @mickeygarcia1876 2 years ago Dr David Sinclair Probably Thinks That Dr Brad Stanfield Is An Impertinent Twerp !!! LOL !!! 1 Reply @oshkotosh2341 3 months ago Well.... this can't do but good! Now Sinclair has to do better... Reply @SquatFull 5 months ago Is this another case of what happened with resveratrol, failures for his studies to be confirmed by other scientists? Reply @MarieCrossbow 2 years ago Pretty sad. I think this is a "bury your head" in the sand issue. 1 Reply @panoshadgipavli8282 2 years ago tell us something coming from you that improves health Reply @Philly1958 2 years ago If you sold a company for 780M for a product that doesn’t work I think you would still be backing it. 1 Reply @0ptimal 2 years ago So is he now viewed as a sort of snake oil salesmen by his peers? Kinda the vibe I'm getting. Plus him sharing only that old paper, as if all he needs to do is defend it and everything stays afloat. Seems to work because he's gotten quite popular last few years. Reply @zack_120 3 months ago Ego, the thing that complicated Homo sapien's history and, continuing ... Reply @gregariousguru 9 months ago This reminds me of all the diets fads every decade.....what's good for you today, changes tmrw. #foodpyramidscience Reply @jnsmeets 2 years ago Thank you Brad! Isn't Harvard's motto "Veritas"? I’ll stick with the Ορκος and my man Hippocrates of Kios. Reply @4evaavfc 2 years ago Sounds like Dr. Sinclair is in a similar situation to GSK, except he is only one man. Reply @georgerichards6629 2 years ago (edited) That's the reason why I don't buy "newly discovered" life extending medicine or supplements. If you want to live longer, stick to the basics: eat like our ancestors, exercise and get enough sleep. Reply @reneoyanadel3377 5 months ago Main Question ! How old are you ? If you are over 50 I will believe you Reply @gabebabe1 2 years ago Sue him for libel Reply @search620 2 years ago Maybe do an online live debate if possible (head to head)... Maybe this will solve this problem. You two have what to say in that field. So unfortunates that's is going thay path. You are not a children's. WTF is going on Reply @quaterman2687 2 years ago Well, I’m simply disappointed in his response. Reply 1 reply @tonywillingham8109 2 years ago That was not much of a response. He must really resent the push back. Reply @sw8281 2 years ago I've become sceptical of Sinclair. Watch his new channel and he pumps lots of products. Seems to me like he needs to raise cash. Reply @Alan01 2 years ago David Sinclair: "Regarding my resveratrol research and the reported $750M I received from GSK: Oops!" Reply @joergmueller6714 2 years ago Well, unfortunately in this video only shares quotes from a bunch of papers. I think some people may find it useful to catch these other papers. But what’s the new insight and the opinion? Or just catching clicks ? Not sure. Reply @hhf39p 1 year ago The response is disappointing. Is he a scientist, or is he a player? Reply @WhereNerdyisCool 2 years ago You know with all these lame witty retorts and emojis....he could just entertain a conversation. (Also, any thoughts on resveratrol pterostilbene?) Reply @piebutt880 2 years ago Multitude of papers by anonymous data by who? Funded by who? Research echoing each other? No transparency. I missed all of these on your previous video. Reply @alistairproductions 2 years ago The oldies are the goodies for life extension. Niacinamide, coq-10, vitamin k, aspirin. Nothing exciting Reply @ralphboerner13 2 years ago I guess the adage that money talks, bullshit walks isn't true when it's $720,000,000; the bullshit keeps walking AND talking. Reply @sunmoon-84 1 year ago (edited) Professor Sinclair is not obliged to respond. Reply @henryjraymondiii961 2 months ago Let's "summon" Albert Einstein to argue with a thousand folks who disagree with relativity. DUH. Reply @anomadlife7397 2 years ago This non response does nothing to help his credibility or that of Resveratrol. Though I wonder if Sinclair was actually the one who responded to the tweet. It could be a hired employee or social media manager. Reply @Car6on 2 years ago Y’all all some haters . 1 Reply @fitnessnature 3 weeks ago Aging is bad hmmmkey ? Don't do aging hmmmkey Reply @MikeG-js1jt 2 years ago See Stanfield, this is where you made your biggest error, failing to approach Sinclair in a way that would paint him into a corner, you have now unequivocally lost that chance, Sinclair now holds nothing but contempt for you and sees you as a threat..... as someone with an AX to grind, there is no way in hell he's coming on your show, you should have gathered all this info, without presenting it to anyone, then got him onto your show (however) and then proceeded to present the info to him while recording............ although something tells me he may be processing all this info before deciding on a response he can live with. Reply 1 reply @geoffcarr6869 2 years ago Given the benefit of the doubt, perhaps Dr David Sinclair made an error he his studies before it was GSK. What is disturbing, is that when he was asked to clarify the matter, he posts that 2006 study, and fails to make reference to any other study. That is intentionally misleading at best. He could have owned the oversight in his research, or he could have admitted that despite earlier research it has now been shown not to be effective, or entered into the debate by saying this is the conflicting information. But no, he just provides the 2006 study, and provides it, inferring this is all that needs to be known. I only subscribed to his YouTube podcasts two days ago. Now UNSUBSCRIBED. 1 Reply @zze4344 2 years ago Think first... why the data come from in this year when everybidy excited to follow and be healty...take care of their haeltyh ...and you know to test in lab what ever infoemation regarding to gate qll data .. is not free...it can take a lot of money...who behind this think...who give the money..motif behind this...it is a big pharma also... Reply @simonmojarad4806 2 years ago I feel horrible for keep telling my 70 year old parent to take Res supplements. My stupidity, their selfishness. 2 Reply 2 replies @manuelojeda9144 2 years ago Doctor your face is very shiny. Reply @Retronize84 11 months ago Lol Sinclair getting owned. Reply @Igoriok190 2 years ago So you can hype yourself from his response :) Reply @SirGolfalot- 2 years ago I think one would investigate how tests/trials were conducted, before dismissing earlier test/trial results. If results can't be duplicated using same same everything, then there is justification to dismiss earlier research results. Otherwise it's bananas to apples and just Stanfield's opinion. So far Stanfield risks losing credibility. Reply @ProggaWoggga 1 year ago Here's something from Sinclair from last week. https://www.youtube.com/watch?v=0JI30-iPHIc Reply @julianrodriguez5321 2 years ago (edited) lol David responds to criticism with a 16 year old review paper, literally overlooking the past 16 years of findings showing that Resveratrol does didley Reply @luketomsett9176 2 years ago I dont trust what sinclair says !end of !neither should you Reply @meowstermeow2967 2 years ago You come off very confrontational and trying to set yourself up as the new David Sinclair, I don't blame him for not responding. 1 Reply @zze4344 2 years ago I dont about you all...The good think happend to my body when i eat restoverol...indicator for my body to say yes...so i understand want it come to a good thing for our health ..natural source is first thing for me to eat..but medicine from source of no natural plant is the last thing for me to take...when it come to a new evident say that and this...i also skeptical because the data from what ever source is we dont no sure the evident is true or not..So we have to investigate also the eviden statement is from the company or what ever is it from the true or it just to down the good think happend to our mainstream more to natural plant source...the big pharma always feel uncomfortable with the idea of healthy body using a natural source like plant because healty business is very big bussines money for them..NMN also can give the impact of the pharma company...image of the hero of healty from the natural plant like NMN or restoverol is important ...So i am very careful to say anthing because if the big pharma company can give some skeptikal think to people who beliave the natural think can cure them...You yourself know why this think happend because what i know from the earlier stage 1 and 2 year ago 2 big company from pharma also give the bad image about Restoverol ...their lab said...bla bla bla...of course a bad image....ironi is for this case resteverol is from natural plant...our mother nature... Reply @olddouchebag 1 year ago I always felt Dr Sinclair was a bit of a grifter. Reply @johnoneill7349 1 year ago Listen mate stop mentioning papers and do the tests yourself and video them because i was sick before i watched his videos and now my last tests where all perfect and my heart was in better health than it was 5 years ago Reply @wholu8497 2 years ago I remember he replied to you: horse shttt.... Reply @TheMastertbc 2 years ago Im dissapointed in Sinclair Reply @miguelmejia4656 2 years ago you can't make this shit up Reply @mitchellzastey 2 years ago (edited) Just goes to show we all have our biases and egos, no matter what level you’re at. I’m sure He means well, it’s just something he will have to deal with over time if wrong. 1 Reply @penultimatename6677 2 years ago Interesting conversation but misleading even over here. I'm not going to pretend I can defend any side. I am suggesting the so far lack of response from Dr Sinclair is not an indication he cannot defend himself. Or knows the data he is relying on is false. Some of the comments suggest as much. Saying Dr Sinclair is boxed in and can't respond. It would be nice to get a full response or debate. However he does not owe anyone and has no responsibility to respond. This is the guilty until proven innocent issue. This isn't about defending Dr Sinclair. It is about actions. Or in this case inaction used to suggest something sinister. One can question this channel if the motivation from inaction is to prove a point. Knowing he likely would not respond. How many attacts does anyone have to respond in order to maintain one's reputation? Reply @ScottSummerill 2 years ago Maybe can't respond because of potential legal exposure. Reply @TheLeopardGirl 2 years ago Dr Kabeline has his own products for sale I wonder if this is why he disagrees with Dr Sinclair also Dr Stanfield if you actually start your own research and write a paper based on your own trials I might consider what you're saying but at the moment you just sound like you have a specific problem with Dr Sinclair's work. Reply @grandconjunct 2 years ago I cant believe Dr. Sinclair even wasted a tweet responding to thie Dr. Brad clown. Reply @ClassicalLiberalWarrior 2 years ago Dr. David Sinclair is my hero, but he seems drop-dead WRONG about resveratrol extending human life. His brief, odd, lame replies to the reasonable, respectful, and polite remarks of Dr. Brad Stanfield seem very dishonest, cowardly, and evasive. Reply 2 replies @dikeledimogobe5117 1 year ago I m beginning to believe you . Why is Sinclair running way from addressing your concerns? I was a big fan of David , Not anymore. Reply @nagual2335 2 years ago I always felt deep down that Sinclair is a cunning freud Reply 1 reply @kevinmurphy944 1 year ago He took the money and ran and no he smells more ithNMN! Reply @vincec3590 2 years ago Personally I find Dr Sinclair an unreliable scientist who is more interested in financial gain and prestige than doing real science. His comments are condescending and makes him sound defensive about his positions and research Reply @smick1313 2 years ago (edited) David Sinclair has little to no credibility left. That was true before this exchange, but citing bad stale data that has since been disproven? How is this guy worthy of Harvard? 2 Reply 2 replies @bensandoval1383 1 year ago it's not only David Sinclair who's talking about resveratrol and it's benefits along with NMN to the cells in your body there is a bunch of researchers doing that, so now you are telling that all those doctors are wrong or overestimated the outcome of their research and you are the one with the absolute truth ? Reply @kip1622 1 year ago clickbait much Reply @ChuckFrasher 2 years ago Bait and switch from sirt2 and sirt1, and pretending the only research is early on when in fact studies are continuously being published showing benefit. Rhonda Patrick lists a lot of studies on found my fitness. So this really is dishonest, disgusting click bait and nothing more. Reply @kennethnwoye969 2 years ago It's like you have a personal dislike for Dr David Sinclair. Why not address issues and dwell less on his person. Are you unhappy with the money paid to him? 1 Reply @tomlwallace 2 years ago Hey Brad, I really liked the earlier videos where you would look at the scientific studies on a subject objectively. You sadly have turned your videos into click bait. Showing Dr Sinclair s picture and implying he was on your video was just too much. I am unsubscribing. Reply @Aldraz 2 years ago You are ignoring all anecdotal data, instead you should focus on new discoveries. Resveratrol is very old findings and already proven anecdotally from milions of people. We now need to focus on what else works or not. Reply @madgoatspaddling 2 years ago Well, you support a company that actively promotes and sells resveratrol and uses David Sinclair's research to back it up. Have some integrity, mate. 1 Reply @colinfarrell6444 1 month ago Sinclair strikes me as a bit of a bullshitter - with harvard, being an American institution..... He'll fit right in. Bullshit is what americas do best Reply @knockstarstv5711 2 years ago Jesus looks like its all a greedy money grab ugh 2 Reply @KevinKreger 1 year ago (edited) I have stopped watching him because of ego over science. Omission of facts is not tolerable in science. Reply @murraywebster362 2 years ago LOL Prof Sinclair has not really responded to you...... Reply @julienrujner7524 2 years ago Hm... Next time maybe Brad should do better research before promoting Resveratrol. I think it is not fear to blame suddenly someone else who at least did some research and spend lots of energy and money to develop and brink the product to the market. Reply @joshmiller8392 2 years ago He is not gonna respond. He sold his research made ton of money, case closed for him! Reply @mslice09 1 year ago There are hundreds of positive studies on resveratrol...there is definitely a link to longevity..... isolating one study to some negative finds is very ignorant.and unprofessional.. Reply @ashlynnundlall 3 weeks ago Dr. Scamclair Reply @neilavery2632 2 years ago Dood - you are being a bit of a social media drama queen. Calm down. This is very click baity. 1 Reply @manuelojeda9144 2 years ago I take olive oil extra virgin. Reply @Serenoj69 2 years ago Clikcbaity. You make it seem he reacts to you, but in fact he precisely doesn't do that. Otherwise good to be critical. Reply @yiannis.demetriou9696 2 years ago Sinclaire is the top snake oil salesman 2 Reply @Neel_44 1 year ago So this turned out to beca big lie. Suspect same with nmn Reply @eyebrid 2 years ago Sinclair was looking for a miracle profit molecule and put his investment above the science and people's health. 1 Reply 1 reply @DirtyLifeLove 1 year ago Guess Sinclair can laugh with his 100s of millions. I think his fear of death gets in the way of his research. Reply @eyeofsauron2812 1 month ago Yikes Reply @stevenschuster 11 months ago Late to the party...Sinclair is a charlatan? Reply @slickJon33 2 years ago I think that Dr. Sinclair has his pocket filled with cash and he is not willing to back up his claim with the current proven data. He is therefore being dishonest and unethical with real science. He is losing my respect. Shame on him. Reply @jpit644 10 months ago This dude is trying to fund raise Reply @ryancobb7822 2 years ago (edited) It doesn't make sense to me, about the daata point you're talking about Reply @RafaelVasquezUnelectric 1 year ago @ Reply @aselaptl 2 years ago I see only one thing, just try to get attention by criticizing a respected scientist, cheap way to become famous 1 Reply @Lulu-kt6gr 2 years ago I continued to take resveratrol not because of the life-lengthening claims, but because I experienced and do experience a definite positive benefit when exercising. When I take resveratrol prior to exercise, my endurance is noticeably better. I used to do core power yoga sculpt classes and they are very strenuous. They combine cardio and weights in a heated room. Without resveratrol it was so difficult and I couldn’t keep up with younger people in the class. With resveratrol, I had no problem doing everything and More than the rest of the class. Then I read reviews online and other people were talking about the endurance benefits so I knew it wasn’t in my head. I’m still taking it. Maybe it’s not the miracle we once thought but I’m not seeing any evidence here that it causes harm either. Reply @petemarx1129 2 years ago (edited) As it seems Sinclair might be a sort of greedy scientific crook, it becomes gradually more and more recognized fact. His explanations are not convincing to me and are definitely very commercially driven. Reply @OatmealAtMidnight 2 years ago Bottom line, Sinclair is another sell out. 1 Reply @James-el6lj 2 months ago I CANT STAND SINCLAIR Reply @songwritersvillage4538 2 years ago (edited) He won't address important criticism and loses credibility daily, I suppose as long as he looks good for his age he'll have followers....maybe he should become an instagram model, there's less science in that.. 1 Reply @rjrnj1 2 years ago While I appreciate what you discussed in your vid, I'm ticked off about your clickbait-ish title. Reply @doitbettermakeitfaster 1 month ago It's my opinion that Doctor Sinclair is a shyster. Reply @Vasudeva108. 11 months ago This guys just a hater. That’s why he always talking about David. Trying to copy him in longevity. That’s my opinion not a fact people I just wrote my opinion. What’s your opinion YouTubers? Reply @HateDietPepsi 2 years ago Government = politicians/liars. Academia Scientists = politicians/liars part deuce. 1 Reply @miloradmilutinovic7691 2 years ago Un-sub Reply @mixalis6168 1 year ago David Sinclair is a con ! He had financial gains on all those sups sold !! I Reply @walidoulondon8107 7 months ago You talk just to talk Reply @nicoleautumn7742 6 months ago This sounds over reactive and a bit hurtful from you and also you ae making it personal Reply @bq3538 2 years ago You are lying, in Previous youtube video you telled us there is no any human experiments about resveratrol Reply @angelicannihilator 2 years ago Dr. Snake-Clair 2 Reply @mag4926 11 months ago (edited) Dr (lol) Brad, i think you made a fool of yourself in that video. Are you seriously boasting about the number of Twitter likes? At 3:24 In my opinion, this is absolutely ridiculous and absurd! It quickly became clear to me who your target group is... Dr David Sinclair has already achieved more than you will ever remotely achieve in your past and likely future YouTube life Rather be thankful that there are such grandiose pioneers as Dr. David Sinclair. Reply 1 reply @theartificialsociety3373 2 years ago Sinclair has always been a shister Reply @mojust88 8 months ago Hater Reply @Marco-bh9im 2 years ago If David ever agreed to this interview, (which of course HE NEVER WILL) it would've been a banger. Damn we miss out! Btw, that was so lame showing irrelevant papers from 2006, like wt??. Dr Brad, you may be responsible for his downfall - please for your own safety maybe hire some body guards. Reply @miennam2296 8 months ago GO AWAY Reply @marcusrisso7933 7 months ago You dont have the competence to discus those topics Reply 1 reply @vindis79 2 years ago Lets start considering validity by number of likes :)... Seems you need to be publishing new content but don't really have anything interesting. You are the SUN of antiaging. 2 Reply 1 reply @TheOrbitalLocker 2 years ago Lmao what a joke, you heard 720 million dollars and found a flaw in a study.. does it affect his overall work? Is anti ageing a thing? And you are fundraising for research on your own anti ageing stuff? Money grabber all the way. Con men and charlatans about.. watch out. Reply @strangerthings88 2 years ago Sinclair said MANY times resveratrol does very little taken on its own! Seriously who is paying you to just oppose literally everything he’s educated people on over the years?? You’re nothing but a glorified YouTuber trying to debunk one of the most brilliant minds we have in anti-aging science for your own publicity. It’s pathetic 2 Reply @MarcusAurelius12 2 years ago David Sinclair is a weasel. Reminds me of Fauci 1 Reply