Is Aging a Disease? Epigenetics with David Sinclair & Neil deGrasse Tyson

Is Aging a Disease? Epigenetics with David Sinclair & Neil deGrasse Tyson StarTalk 3.08M subscribers 324K views 1 month ago StarTalk Podcast Full Episodes Is aging a disease that can be cured? Neil deGrasse Tyson and cohosts Chuck Nice and Gary O’Reilly discover the field of epigenetics, the Information Theory of Aging, and curing blindness for mice with Professor of Genetics at Harvard Medical School, David Sinclair. … 1,825 Comments Add a comment... Pinned by StarTalk @StarTalk 1 month ago Would you want to live forever? 284 Reply 232 replies @spokehamilton6624 1 month ago My telomeres have shortened just having to wait through all these commercials. 418 Reply 41 replies @mollymcguire198 1 month ago My grandfather's 93, in perfect health. Treated his body as a temple, truly. He ran at least 4 miles a day until he was about 84 years old. We joke that he'll out live the family but we're starting to think he just may! 97 Reply 13 replies @edwardyork7396 1 month ago This the best show seeing Chuck out there showing how great his questions really are. Great job Chuck! 115 Reply 1 reply @jamesopio4898 1 month ago Chuck prepared for this podcast, meanwhile my astrophysicist was swimming in unfamiliar waters. 170 Reply 19 replies @jaimepoliveira8616 1 month ago (edited) The first thing that came to mind is that this could be great for interstellar travel. Extend life for long journeys outside our Solar System, rather than trying to travel at the speed of light, missing opportunities for great research along the way. On Earth, the average of 90 years is enough for many who have no interest in space travel, but for those who dream of getting to know the universe, they need more time to at least travel within our galaxy. Jaime P Oliveira 110 Reply 16 replies @Antispor 1 month ago Chuck Nice is so underrated. Love him so much lol 51 Reply 1 reply @allensanders5535 1 month ago I'm 65 and I want to volunteer at his lab he can experiment on me, we'll see how well it works I'd love to be 40 or even 50 again. 137 Reply 22 replies @riskninja8194 1 month ago One of my fav interviews so far! Your guest was fascinating to listen to! 12 Reply @snowbear441 1 month ago I really enjoyed this podcast. This topic is so fascinating! Please do more of these. Thank you 3 Reply @Adam-nw1vy 1 month ago Glad to see David Sinclair after a long time. I've been following him since 2016 and been a huge fan. Unfortunately, there have been a few controversies surrounding his work recently. Also, there's a doctor from New Zealand called Brad Stanfield who regularly criticizes him with seemingly well-researched and balanced takes. Would be great if Dr Sinclair could dedicate sometime to address the issues raised by Dr Stanfield, particularly when it comes to NMN. 131 Reply 29 replies @palawansen 1 month ago Love this series Keep going! Love you Gary so much, you always ask what I would have asked Great guest Cheers! 3 Reply @tyrone4u559 1 month ago Fascinating episode 12 Reply @vickieysacoff4249 1 month ago This research is so fascinating! Another great podcast. 12 Reply @leonardopinhogomes2101 1 month ago This video was just… Excellent !!! In content and how it was so well explained, about a matter that is intrinsically so important to all mankind! 4 Reply @therecogniser2122 1 month ago Great questions and great answers as always, thank you so much Startalk. 1 Reply @jozette-pierce 1 month ago Dr. Sinclair is super, and so helpful to the average person. Thanks for having him on. 1 Reply @MikeJamesMedia 1 month ago Hugely interesting. Thank you! 4 Reply @davidderidder2667 1 month ago (edited) Truly brilliant interview, historic. I am following this field and the work of Dr. Sinclair for years but this was a very good interview with very pointed answers and questions. And the moments of light humour, well that was just splendid. Compliments Startalk! I will support you. 9 Reply @jorn-michaelbartels9386 1 month ago Great video! Your guest David Sinclair explains all the science behind aging in a very clear and simple way. I heard of his projects first in a video of nature. My congratulations that you had him as a guest on your channel. 2 Reply @matthewdimarcantonio4627 1 month ago Wow the details are eye opening 2 Reply @travishalvorson6377 1 month ago I actually talked to David 10 years ago. Really nice guy. Said at the time, he couldn't recommend any supplements to take, because nothing was proven. I was taken back by how open he was just to talk to the general public and his honesty about his own research and his realistic approach 36 Reply 8 replies @Shat_Tastic 1 month ago I cant believe they got Sinclair on here :) been follow him from the time i went blind in one eye. Nerve damage sucks lol 56 Reply 7 replies @donbazukon9620 1 month ago Hey pops! Great topic. Thanks so much for awakened all that enthusiasm I had about science in school. With your videos I'm learning and getting everything so clear now. Thanks Reply @kasamukabirudawa7900 1 month ago Great talk to listen to in my 41st birthday. Best birthday gift ever. This gives me hope I can still rejuvenate 2 Reply @JJs_playground 1 month ago Im blown away by Chuck's level of knowledge on this subject. 8 Reply @userrnoise2777 1 month ago Awesome show 3 Reply @chaokai3606 1 month ago Such an interesting topic, really enjoyed this video and good explanations aswell :) 2 Reply @SimonJanoSessions 1 month ago always a good for Chuck and Neil! and also for David. 1 Reply @niceboke 1 month ago I had a tooth implant treatment in Japan. They made a stem cell mixture from my tissue and filled the hole from the extracted tooth. After a couple months that hole completely filled in with bone. The result is I don't need metal plates or anything artificial to support the new tooth which will be made completely from Zirconia. There is current research being done in Japan to grow new teeth. So maybe we won't need implants in the near future. 4 Reply @gloriouslysarcastic8000 1 month ago Chuck is the real genius here! 22 Reply @gotxe 1 month ago This was a great talk, thanks! 2 Reply @eddiecampbell3514 1 month ago Gotta love Lord Nice's impressions they are often spot on. Even if he's channeling his inner dr and recalling things he remembered about certain studys that have already taken place.. has a great recall memory when it comes to that.. I think Dr. DeGrass is rubbing off on him some so he's been in startalk dr college courses lol love it he's also gettin smarter everyday as well as us just watching the shows regularly! Love this show.. its my favorite by far.. I'm always interested in watching a new video and alway always always save it for later that day if I couldn't watch it right away because I'm at work and I don't wanna miss a show.. keep looking up folks!!! I know I love to at night when it is its darkest out and not so many lights on. Fun to see the stuff zipping across the skies at night almost on a regular basis for me anyways... but I think some of that is just a satellite repositioning in some areas.. ( just my thought) but fun to watch bc sometimes I see something smack into something and knock it across the galaxy Reply @lazrus7049 1 month ago $2.00 Thanks! 7 Reply @-Mohog 1 month ago Quite amazing. This is also interesting regarding space traveling. If we can increase our lifespan significantly, we don't have to worry about the distances and time it takes to travel from one place to another quite as much then anymore and it would make it possible to make longer trips even if we won't discover some new amazing way to travel significantly faster. Although the distances in space are so vast the lifespan increase should also be quite immense. But at least in our Solar System and perhaps even enabling us to travel to Proxima Centauri and back within a human lifetime could become more of a reality. Perhaps even a few other closest star systems. Very intriguing interview and information. 9 Reply 1 reply @williammankel376 2 weeks ago I appreciate the update on the aging research and would like to know what books and journals to read to more fully understand this field Reply @tyrone4u559 1 month ago Outstanding video, very interesting. I think there is no doubt that the biological aging process thing will be figured out, hopefully soon 19 Reply 2 replies @raychang9512 1 month ago It's one of the best interview of Dr. David Sinclair. 31 Reply 3 replies @GoldyMcGoldface 3 weeks ago This was a great episode. David is so affable and everyone is just having a great time talking about some great science. Reply @alexharvey9721 4 weeks ago Excellent interview, thanks! All jokes aside, you can really feel the enthusiasm for the possibilities on the horizon. There will be so much money in it, it's hard to imagine how this research was so stigmatized and uncommon a few years ago. Lifespan was a great book, definitely recommended! Reply @waynehedd 1 month ago Get Bryan Johnson on please!!!! 5 Reply @alswedgin9274 1 month ago 5:50 Damn, Chuck..dropping a bomb question 7 Reply @floior89 1 month ago Wonderful, interesting, thought provoking and educating! It's a wonderful channel with a wonderful host and wonderful participants. Reply @tommycollier9172 1 month ago Very interesting episode Neil Thanks for sharing 1 Reply @chrisblack9851 1 month ago Reminds me of the movie The Fountain when Huge Jackman said "death is a disease like a virus and there's a cure for it" 13 Reply 1 reply @Rob-eg8qc 1 month ago Both of my parents are nearly 100 years old and are still in rather good health, their parents lived will into their 90s too. I and my 2 sisters are into our 60s with no health issues, maybe just lucky, but personally I also think it has something to do with your genes past down from your parents, having 1 balanced meal a day gives your body a chance to repair itself rather than spending most of its time digesting food, I'm not to sure, but I definitely think genes play an important role in longer life, great show, all the best from the UK. 14 Reply 6 replies @lorisfoucart2475 1 month ago Fantastic episode 1 Reply @MichaelDembinski 1 month ago This is StarTalk at its best. Relevant, informative, detailed – and hilarious. Thanks guys! 1 Reply @joppadoni 1 month ago Can't wait to watch the follow up in 60 years time. As always, keep looking quadranguarly.. ;-) 3 Reply @Theanalyst-pz1ui 1 month ago I am a data guy, and I don't think population will increase. If we look at what happened last time life expectancy doubled. We went from having 7 children, to 2 children. We went from having children at 15 and 16 to children at 25, 26. This is because back in the 1700 and 1800s people only lives to be 30-40 years old. If you were 15, or 18, you were middle aged. Now we frown on teen pregnancies. I think based on what happened last time we doubled the life expectancy, people will wait longer to have children, and we will go from 2 children to negative birth rates. 15 Reply 2 replies @BakerBaker-xc3uh 12 days ago Thanks so much.. Reply @BobLinton 1 month ago Thank you very much. Reply @wanfuse 1 month ago (edited) what about: myeloablation and transplantation where patient receives stem cell transplant from a compatible donor (allogeneic transplant), has studies been done on patients with total myeloblation, whether they become young as the donor? surely this has been tested in patients with leukemia? I assume this would test the information theory?myeloablation" or "ablation," depending on the intensity of the regimen. Transplantation: After the conditioning regimen, the patient receives the stem cell transplant. The stem cells can be donated by a compatible donor (allogeneic transplant) (post a deep fasting period of 5 days?) 3 Reply 4 replies @dwaynesmith5341 1 month ago By observation of the 'immortal' jellyfish, or Turritopsis couldn’t we figure out how to trigger this in humans? They rewrite/reprogram the identity of its own cells, returning it to an earlier stage of life. 13 Reply 3 replies @sarahalbert6833 1 month ago Neil, Gary, Chuck. Love your channel. It is a science fiction writer’s dream & great research resource 1 Reply @atfaxxx 1 month ago Love to soak in the knowledge they talking about and chuck just makes it fun Reply @oneofus6924 1 month ago every time i see David over the years, he looks younger and younger. he is really walking the walk 6 Reply 4 replies @thechairman74 1 month ago So from a superpower perspective, it can be explained that people who are immortal have the ability to rewrite their genetic code constantly to avoid aging. 21 Reply 1 reply @goodtothinkwith 3 weeks ago Wonderful interview 1 Reply @calvingoh9321 3 weeks ago Love the energy. Reply @jessejorgensen3931 1 month ago Extending life is the only thing that will ever get us off this rock 8 Reply 1 reply @sakismpalatsias4106 1 month ago Aging is an evolutionary lay over, that served a purpose in the past. In order to overcome our prior evolutionary hurdles, we developed an intelligent mind. 27 Reply 8 replies @user-ox1ur1ij4t 1 month ago Thank you Reply @lleston8927 3 weeks ago (edited) Amazing content! Keep it coming! I would like to live until there is no point on living. I mean until I lose the spark that keeps me going. Reply @TheMaestromMephisto 1 month ago There will be a time when life expectancy would be 150 years, right now average is around 70ish years, see the way we are shocked our ancestors lived only 35 years, our future generation would be shocked how we used to have a low 70 years expectancy 12 Reply 4 replies @Yamaprilia 1 month ago There is an exception already in nature. Its the eternal jelly fish. It can restart its ageing process if it gets damaged or unwell. Please check it out 7 Reply 1 reply @omittapir5986 13 days ago Do glad to see Dr Sinclair after a loooonnnng break! Reply @matthewcardenas5124 2 weeks ago I am a year away in a biomedical science bachelor due to this topic and I’ve been obsessed with this since I was a kid Reply @ThanosDestroyeryearsago 1 month ago I’ve been seeing stuff on longevity recently, really hope it happens soon. 15 Reply 24 replies @techgayi 1 month ago audio is a bit iffy for this talk, did anyone feel it ? 3 Reply @karlgoebeler1500 1 month ago Question. Caterpillar metamorphosis. Restarting the Hox cell body plan and starting the cell different ion process? 2 Reply @GlacialRidgeHomestead 1 month ago Love this video! Reply @Sammasambuddha 1 month ago (edited) I've seen things you people wouldn't believe. Funny thing. I wrote that quote before i saw Neil's copy of Bladerunner in the background. Subconscious sheet there! 6 Reply 2 replies @OM4Rx 1 month ago We love you guys from South Texas! 1 Reply @cryptopapi4737 1 month ago @Drberg I think could be a great guest regarding health, the keto diet, fasting, and autophagy. Reply @EmpyreanLightASMR 1 month ago 0:40 "my favorite stand-up comedian" RIP all other cohosts (but for real, this is the dream team, you all are amazing) 15 Reply 1 reply @geoffreyrhine8210 1 month ago Question - as you applied this therapy to extend the life of the mouse called Dorian, did its picture get older and turn Gray? 3 Reply 1 reply @mylesanthony8672 1 month ago Thanks some good info there Reply @justinlowe5678 1 month ago Nerds who made it big! Love it! You guys were the kids I made an effort to hang with it in highschool and college years! 1 Reply @xavierowino 1 month ago (edited) Wait a minute...pls clear up the confusion. People think sinclair conned his way through with data that can't be replicated for some studies he did before... 5 Reply @hopper2716 1 month ago is it me or has Sinclair's looks changed... this almost looks like a different guy but in a weird way, not in a younger way... 12 Reply 7 replies @afiadawn 3 weeks ago this was mind-blowing. so incredible. how is this not front page news? Reply 1 reply @steve-real 1 month ago Super exciting! 1 Reply @carl7674 1 month ago With all due respect... I'll believe it when I see it. 6 Reply 4 replies @jeffsiegwart 1 month ago Exciting and interesting stuff! Thank you. 1 Reply @HulkSmash512 1 month ago (edited) I love how Neil gets defensive over Chuck like no no we need him here He wasn't letting that slide haha 5 Reply @jasonta12 1 month ago I definitely remember hearing about epigenetic changes being passed down by survivors of the Holocaust. Definitely something very interesting to think about in regards to how our bodies react to the world 2 Reply 1 reply @SARVX_ 1 month ago Informative... Reply @aitarun 1 month ago (edited) sometimes i feel Chuck chose wrong profession, he could be a great biologist, scientist or philosopher. I like his comedy but he can have many avatars 7 Reply @mintsprig7 1 month ago This is so interesting! Great stuff. 3 Reply @Avi-gk2my 1 month ago (edited) this is Beautiful Reply @davidpelletier7409 1 month ago Very interesting talk, would love to hear an update on this. Like Neil, Show me the 12 year old mouse! Great discussion. Thanks Neil for talks like this. 2 Reply @haudace 1 month ago Aging is what I call a self correcting problem of life 10 Reply 1 reply @chuckzilla3000 1 month ago So telomeres are basically a chromosome’s fuse. Fuse runs out, chromosome kinda goes boom. 6 Reply 3 replies @Michael-0490 1 month ago Just bought some liposomal NAD+ thank you for this. 1 Reply @houssamk777 1 month ago Great questions i might add Reply @pundah7084 1 month ago I don't like the idea of living forever but extending our lifespan sounds amazing. Imagine if we could double our lifespan. 4 Reply 3 replies @Elzelgator 1 month ago Chuck is a really funny dude. He is getting smarter too... 3 Reply 1 reply @mattyj101 1 month ago One of the greatest topics of human history, examined by and researched by some of the greatest, most resourceful, single-minded, sometimes cruellest people who have ever lived, and obsessed over by many. A touchy subject indeed. Reply 2 replies @lawrence.5898 1 month ago Really Nice. Reply @hanstubben 1 month ago Max Verstappen, the F1 driver, is a prime example of epigenetic heritage. His mom was a kart racer and his dad was a F1 racer. At 17 years old Max got in F1 and now at 26 he´s a three times world champion. 7 Reply 4 replies @bigmotter001 1 month ago I am sensing that Sinclair has more than one plan to sell you something? Due diligence is definitely necessary here and take care! 5 Reply @funghouls5498 1 month ago What a wonderful, enlightening discussion on Sinclair’s research 1 Reply @Theunknowable_ 1 month ago Just Great... Reply @axel_r_ 1 month ago David Sinclair is one of the pioneers of longevity and the future humans are now creating. Question David! Be sceptical! Find evidence he is wrong! All of these are good things because if you prove what is wrong, you can narrow down to what is likely "right". But never call David a charlatan. That is simply ignorance. David has a proven knowledge of longevity on so many levels, and there is a reason he is on the show of Neil, who also has a lifetime of proven accomplishments while the wolves in the comment field here scream "CHARLATAN". You remind me of the people back in the day who screamed "BURN THE WITCH". 6 Reply 1 reply @geoffreykail9129 1 month ago (edited) This is the best and most informative episode you guys have done. And Chuck kept a little milder. GOOD, he is funny but more good science is better. 6 Reply 2 replies @richardkrent5819 3 weeks ago I’m 70 and my goal is to live to at least 1,000! Now I’m thinking that is still too short! Please continue your research and share it with the world so we can learn more and experience more while exploring our universe! Thanks for all you do! 1 Reply 1 reply @spwatch32 1 month ago I had a couple good laughs and learned some things! Great enjoyable conversation. Thank you. Reply @ctakitimu 1 month ago (edited) Would I want to live forever? No, you can only do everything so many times before boredom would set in. This is why heaven would suck after a few trillion years! However, I wouldn't mind a few thousand years. edit This all sounds great, but it'll only be accessible for the elites. Us worker bees won't get to have the longer lives. I know this because I know humanity. 3 Reply @deucedaprodeuca 1 month ago It is said that the first person to live forever, is already alive. 64 Reply 39 replies @craigstiferbig 1 month ago A methylation panel or screening will tell you what you need to supplement and what to chill out on or discontinue completely Reply @vishalbhusari1271 1 month ago Very Nice... Reply @alwayslearning8365 1 month ago The FDA and the medical establishment has to recognize and accept aging as a disease. Once it is officially accepted as a disease it will open up aging to a huge amount of research. 7 Reply 1 reply @thecuriousquest 1 month ago David looks like he's already applying it to himself. 54 year old lookin' like 35. 3 Reply 1 reply @FougaFlyer 1 month ago great show ! 1 Reply @tatotato85 1 month ago cool stuff, im gonna rewatch it in 70 years to see how it holds up 2 Reply @thegarch3293 1 month ago Nice face lift Sinclair 3 Reply @patludwig1971 1 month ago I'm in my 70s. I look 50 and just started skateboarding again. I also smoke. Chuck, you're real funny. The only disease I'm worried about is Trump. This, too, will pass. I love Startalk. Thanks, Neil. You have the slickest ways of shaming idiots! I just wonder where they all came from 14 Reply 1 reply @taahirahchothia6036 1 month ago Love a David Sinclair 1 Reply @lance_goosen 1 month ago Chuck killed it. Reply @mobilegameplaywalkthroughs990 1 month ago We'll know this works when Elon Musk starts looking younger. 4 Reply 3 replies @kban77 1 month ago Sinclair is selling sketchy supps 6 Reply @Banefane 1 month ago This is huge! Reply @drgenshin06 1 month ago We want something just like this Reply @emilyhays6458 1 month ago I think aging is a process. 3 Reply 6 replies @SparkyWrench 1 month ago I like how I get older AND dumber. 6 Reply @jtgullickson6117 1 month ago Chuck Nice, you are a rockstar. Much love brotha, peace. 🇨🇦 1 Reply @givemeacutenickname1500 1 month ago Neil I'd like to hear your thoughts on 3 body problem Reply @davidbrianmoore3783 1 month ago What a fascinating science. It would be great to know how treatment or the process is going to work for humans in the near future Reply @smartbutuneducated8637 1 month ago Interesting episode I hope to track down some materials to inform myself better on this. Pardon my ignorance but to convey myself I need to describe things in terms of a computer system. In terms of hardware (DNA) or operating system (epigenetics). Medically interesting about reproducing a peripheral (eye) but two things with this episode stuck with me. A backup copy exists but you are not really sure about where it exists yet. How can you trust this backup? How do you know when it was made? Also this backup does it contain the up to date drivers for the peripherals or is the experiences you have create those and your rollback actually removes your efforts to better suit those cells to its environment? Would this reset immunities built up? I hope I find the materials online to better inform myself. 2 Reply 1 reply @jamesc954 1 month ago I recommend David's book Lifespan. Very informative! 2 Reply 5 replies @herrsygma 1 month ago (edited) I think that it would be very interesting to see a Startalk review&analysis episode of science presented in The Three-Body Problem(the Netflix tv series, the book or both). Reply @pathtoknowledge6847 1 month ago Please make an interview with Dr. Aubrey de grey as well 2 Reply @therealleijames 1 month ago Yes Reply @anoniaciesluk3273 1 month ago Wow quite a subject. 1 Reply @tomwirt319 3 weeks ago Thanks, Chuck, i just turned 81 this year. Reply @elizabethstafford984 4 weeks ago Also does this have anything to do with crispr cast 9 Reply @coreyerwin2536 1 month ago What about increasing metabolism, any effect their? Reply @Dcjoe94 1 month ago What about david Johnson and his work I suppose in the field his dietary things ? Are those ?, important to the study of anti aging Reply @Sukisunn 2 weeks ago Ok so... Believe this or not... I have been doing a similar experiment on my self. Thinking along the same lines... But it's really really really nice to hear a Harvard professor talk about this. Learn something new every day... Exciting. On another note... Both my parents are intelligent... Both also have mental disorders... So now you have a super intelligent super disordered person... And that's what has lead me to what this professor is talking about. Doing my best to well guide my self to repair... Treading a path that not much guidance is available. Reply @wellingtonceron1113 2 weeks ago Chuck for president! Reply @rojilander7212 1 month ago Interesting Reply @abhishektrivedi5772 1 month ago Awesome Reply @kentroglobalinvestmentllc8921 1 month ago Corruption of the “epigenomic” profile, or one’s “original software” is an interesting analogy @ 6:00 .Never thought of that that way Reply @geoffreybrowne5191 1 month ago Yes, Yamaneika is ridiculously funny. Her set about the submarine implosion is a killer set. Reply @jaysonwallker1648 3 weeks ago Do you know anything about Astralagus? Anybody know anything about telomere research? Reply @billalumni7760 4 weeks ago If you can regrow an optic nerve, what about severed spinal columns of para or quadriplegics? 1 Reply @Dcjoe94 1 month ago David Johnson and blueprint ???? Please talk about him and what u guys think Reply @C0yf1sh 1 month ago Gary’s introductions are always amazing!! He needs a highfive! ️ Reply @dimitri1515 1 month ago a study many years ago showed that the percent strength loss from age 20 to age 90 is only 35% if a person lives a fitness oriented lifestyle the whole time.....and I also assume avoids physical accidents and major illnesses. 1 Reply 1 reply @079Francvs 1 month ago Tengo una duda. ¿¿Y que con los telómeros?? ¿¿Una vez se rejuvenece la célula los telómeros también volverán a la normalidad?? 1 Reply @EffortForever 1 month ago The intro had me hooked so freaking funny man! 1 Reply @TheJasonBorn 1 month ago So what was the name of that company again? Reply @samsongihoul3298 1 month ago I'm curious if this would be good to reconnect spinal cords... Reply @grantlauzon5237 1 month ago Would this affect bacterial or viral diseases? Reply @babybleunotes 1 month ago Hi Neil, you're coming to my town and I've only been a subscriber for a month or 2. Hope I can see you at the movie show live in person 🪽🩵🪽 Reply @maddocmucmaddocmuc5341 1 month ago What happens to injuries? Is it thinkable that injuries (e.G. amputations or congenital non genetic deformities like thalidomide) disappear or do we need to go back to the pluripotent stem cell? Reply @Imhere12345 1 month ago Great episode. Chuck has learned so much I barely recognize him. Still funny tho Reply @augu_3st613 1 month ago I didn't expect Chuck to look the way he does Reply @azizanativegirl7073 1 month ago Very funny entertaining and informative thank you all!,, Reply @TheRabbitRonin 1 month ago (edited) 34:54 I had to go back to see if I heard correctly that he said the name Deadpool and he did and I think that's awesome! 1 Reply @cornfieldexpress 1 month ago I'm thinking of this as an Android phone in Developer Mode. It needs to be accessed and once done, modifications can be carried out to make the software customizable. I think DNA has a developer mode and AI will help us unlock this. Reply @martelclark4613 1 month ago $1.99 Let say a machine is made like the movie “Elysium”; would ppl matter the budget an accesses to this geno copy to start journey of a long life? Also would it be a problem far as this Genos being turnt on therefore would it be a bad outcome for that person keep making cells for that part of the body that geno suppose to be zombiefied? 1 Reply @MedicatedGaming 1 month ago Why is this not absolutely everywhere? It's absolutely insane, especially because he said they're going to start human testing NEXT YEAR! 1 Reply 1 reply @hansu7474 1 month ago Terminology is a bit confusing. So in the information theory of aging, when David says 'back up copy', it means the extra information included in data, in order to restored a damaged datum. Is this correct? Reply @masongovender9231 1 month ago Chunk is really the Master of this show, not to mention how well read and prepared he usually is. Reply @learn-grow-live179 1 month ago (edited) I've always admired this channel for its commitment to delivering insightful and authoritative content in the field of Science. However, I'm surprised by the choice of featuring David Sinclair in this video. Given that some of his work has been highly controversial and has barely been replicated—some claims have even been disproven by other researchers—I hope future guests will align more closely with the channel's standards. 1 Reply @bobbymunroe8602 1 month ago I would like to hear what you think about Gilbert's syndrome, from the studies I've read increased bilirubin can have the effects of lower cardio vascular disease, anti mutagenic properties that can prevent cancer, lower fat storage. One study said aversion to mortality. Any thoughts on this? Reply @brazilforreal1 1 month ago (edited) Not the Wright Brothers but Alberto Santos Dumont invented the Airplane.The first one that really fly. 1 Reply @WildlifeWarrior-cr1kk 1 month ago Chuck for president Reply @zommoliv8525 1 month ago (edited) Now I understand why there’s not that many molecular biologists ppl that socially inspire via the internet like Neil—I specialize in proteostasis and not once have he talked about proteins and I disagreed with some of the things he said… most likely bc I misinterpreted the points he tried to make… as he tried to “dumb” it down— Biology is insanely complex and so I understand. Reply @JMSsssssss 1 month ago (edited) From what I understand, Sinclair has petitioned the FDA to ban the sale NMN in the US, after he told everyone they should take it. One of his companies stands to gain from that. 1 Reply @dinaabril806 1 month ago @StarTalk, I'd love to share with you & the Harvard gentleman how I'm aging 8 years slower than my chronological age. Curious to know his thoughts. I've activated genes in my body, one being NAD production. Reply @01Grimjoe 1 month ago With Diet wasn't there a study base off a large group who moved from Okinawa to Hawaii as they went from one of the longest living groups to one of the shortest? Reply @seanmchugh6263 1 month ago Ricly funny. Well done! Reply @nicholaskoenig3106 1 month ago Does anybody remember the study with carbon 60? And the mice lived 2-3x 38:20 as long? I believe it was a double-blind.Pure reviewed pretty awesome study. Reply @GeorgeSchumpf 1 month ago (edited) this information theory of aging, What actually happens to the information to bring on age? Is it basically entropy, or is it more complex? Reply @daveperteet 1 month ago Epigenetics videos never get old. Reply @franklinwaltz3978 1 month ago I respect dr.Sinclair so much for all he has done, I mega dose nmn, resveratrol and following his supplement product for years now im 60s people thought im late 20s wow. Please keep helping humanity Dr.Sinclair. Reply 2 replies @radarshak3092 1 month ago This would be great for interstellar travel since we seem further from figuring out FTL travel anyway Reply @erinjk123 1 month ago (edited) I was like it is all connected. Ps - this is exciting. Sounds like it is being narrowed down. Reply @nancycorrea9319 1 month ago Neil, I love, see one video with Sinclair And Dr. William li, this speaker are really cute! Reply @jacobshocklie2928 1 month ago The months after birth are considered the most important for development, If skin-to-skin contact is not given the potential for mental health issues increases exponentially. Reply @Vshamann336 1 month ago 32:57 how do I apply this all in my life and how do I take advantage of this knowledge? Reply 2 replies @JiKwon 1 month ago As I see it, you are talking about decay, which overtime leads to errors (disease). And as with anything else, it's best to stop “errors” before they happen. And for that we need all the tools that can be used here. We can't do that today, because some of them can only be used when the “errors” has occurred. We must change that, not by calling decay something wrong, but by adapting the outdated rules to modern needs. Using a word that people have all sorts of different perceptions of like age. Is crazy, rather than an accurate descriptive word. Reply @gmichia 1 month ago Wow the dr looks 10 years younger from the last time i saw his interview. Reply @AlenaChapmansoulmanifesto 1 month ago I love this! A wonderful topic. My question: are people for the most part, going to want to live forever? Aren’t most just trying to live healthy But they don’t want to live into the hundreds? Thoughts? You guys are amazing and this form is great. Reply 1 reply @kevintruman9981 1 month ago How can these affects hormonal system. Reply @FastFunFactFriday 1 month ago Is the biological stress analogous to bacteria, such as clostridium, forming a capsule for years to survive harsh conditions until they become favorable? Reply @AlenaChapmansoulmanifesto 1 month ago Also, another question: if a person is changing their behavior – what they eat the exercise cleaning up their act basically, then they’re changing their epigenetic code? True? Or do we need actual change in the epigenetic system itself to affect the DNA Reply @Darkeiser.7 1 month ago How do I sign up for clinical trials? Reply @TakeShotAction 1 month ago I felt a little bit worried toward the end of the interview that a lot of what's being said might be overly optimistic due to David's advice on diet. The studies on meat have long shown to be flawed at best as far as controlling for outside variables in conjuction with what constitutes a "Meat-Eater" as compared to a "Vegan, Vegeterian or Pescatarian". There's something called the healthy user bias, in that people who are more likely to follow a diet that restricts red meat are likely to be highly health conscious people who avoid processed foods all together. What we call "Meat-Eaters" includes people who just eat everything, even if you have a small amount of bacon on your pizza or get take-away with a burger, fries and a giant soda and that's all the meat you have in a month people still consider that a "Meat-Eater". This concept is known as "The Healthy User Bias" and isn't controlled for in any experiments comparing different diet styles. I just hoped that David would know better about the current controversies surrounding these things. 1 Reply @jeffreykipperman6894 1 month ago (edited) If you watched this not knowing who anyone was, you wouldn't know between Neil and Chuck which one was the scientist and which one was the comedian. And I mean that as a compliment for both of them! Reply @Yakamatsup 2 weeks ago My mom lived to 102, her mother and aunts lived to mid-90’s. Great genes, good eats, active lifestyle, decent social network, limited alcohol and NO SMOKING and lots of matcha/green tea. Actually a focus on healthy foods including fish vs burgers, limited inflammatory food, lots of fermented and pickled food. Reply @steve-real 1 month ago I wonder who works in David’s lab is the next level wonder kid in this field. Reply @nemonomen3340 1 month ago 25:40 This whole bit had me in a giggle fit and I was eagerly waiting for someone to bring up Jurassic Park. Reply @mecdrum7 4 weeks ago How do we get this ? Reply @samsongihoul3298 1 month ago I'd love to be a test subject 1 Reply @brycehuff 1 month ago How do we DIY turning on the O, S, and K genes? 1 Reply 2 replies @rhcreek 1 month ago $10.00 Thanks! I'm not a scientist, but love science and teach a general science High School Equivalence course. Last week I was studying early life forms- specifically the evolution ofaerobic life forms. An article I read stated that, since Oxygen is toxic to humans, over time it damages and mutates cell DNA and that is the basis for aging. Based on this video, our birth DNA is the original disk (the CD) for our cells-scratched by Oxygen toxicity as well as damage from diet and other chemical imtake such as caffeine, nicotine, drugs used (regular use of Ibuprofen or Tylenol--- much less illegal drugs) In theory of this discussion of reversing aging by returning our cell DNA to it's original format---very interesting!! But how, since the original DNA/data CD has been changing since birth (or before if mother partook of drugs during pregnancy)?? 2 Reply 1 reply @nedkelly8167 1 month ago This is what ChatGPT says "Sinclair's claims and methodologies have sparked debate among other scientists. Critiques have been made about the rapid peer-review process of his studies, potential conflicts of interest, and the safety of the molecules used in his research. Despite the controversy, Sinclair's research has contributed to a deeper understanding of the mechanisms behind aging and has opened up new avenues for exploration in the quest to mitigate age-related decline. The debate surrounding his work underscores the complexities of scientific research in this area and the importance of continued investigation and discourse." Reply @VeneficusCubes 12 days ago Nothing is impossible, but many things are impossibility hard to achieve Reply @jessalexander6275 1 month ago I wonder if different frequencies might have an effect on epigenetics. Reply @aquahood 1 month ago Yes because I would never stop learning I would go back to school and I would actually become a cosmetologist, a medical doctor, I would learn all the languages, I would learn how to play every instrument, and more and more.. Reply @alvaroluffy1 1 month ago i have a recommendation, maybe limit the quantity of ads in-video per video to one per video, that could discourage some people of watching the content. Although, i assure you it wont discourage me to stop watching the content. But i think it may annoy some other people on a larger scale Reply @ledrash6079 1 month ago 7:11 You knew everything, Jon Snow! Reply @CallyMan90 1 month ago I get the feeling that ageing is a fundamental mechanism of life in the universe, and that we can influence it to an extent. 1 Reply 1 reply @StormDjinn1 16 hours ago I have so many questions! If I point to animals that are naturally vegan and exercise often, then still die from age, what are they missing that your mice or you have David!? Please bring him on again! Reply @rodrigocampos55 1 month ago Very interesting video, but man, SO many ads! Reply @noahtrue4950 1 month ago (edited) I'd like to mention that the Wright brothers were the first to build a modern aerial plane. There however were other flying machines before this dating back to the 1850s The first sustained powered, controlled flight in history is believed to have taken place on 24 September 1852 when Henri Giffard flew about 17 miles (27 km) in France from Paris to Trappes with the Giffard dirigible, a non-rigid airship filled with hydrogen and powered by a 3 horsepower (2.2 kW) steam engine 1 Reply 1 reply @athanatic 1 month ago Any change you will review the accuracy of the 3 Centauri stars in Netflix "3 Body Problem?" Very chaotic! Reply @nighttalkersmedia 1 month ago If you want to stay young, be born into wealth, get an academic job and never experience real stress, the very thing that actually ages you the most. 1 Reply @AwesomeAutismAdventures-bd1cw 1 month ago I'D LOVE TO HEAR THESE GUYS TALK ABOUT AUTISM 1 Reply @daddy7860 3 weeks ago I'm only at 21:30 now, but I'm thinking if there's a backup copy, wouldn't we also be resetting our memories? Reply @MysticJhn 1 month ago My question with using these epigenomes to basically reset aging is that would there be a point that human beings just cannot live beyond regardless of these therapies? So you develop a way to, for example, age a person down from 70 back to the body of a 40 year old. They might look 40 again although they are 70, 80, 90, etc.. Would there be a point where, no matter how much you upgrade and restore the operating system of youth, there's still nothing left for the body to give? A virtual age limit. For example, no matter what, no human being, regardless of how much de-aging therapy they get, cannot live past 250 years old. They might have nothing left despite being in 35 year old shape. I mean, sure, I can boot up a computer from 1997 and keep it clean and functional, but at a certain point the actual electronics are going to break. Even if the computer is running the most well put together and updated version of Windows95, a Windows95 designed for 2024's WiFi and internet, the wiring will eventually decay. Or are you saying that, potentially, this epigenome therapy would be akin to Windows95 knowing how to rebuild the circuit boards? 1 Reply 1 reply @alex84621 1 month ago The question is do we eat complex foods or less complex foods. Because meat is the most complex by far compared to plants. To me it's obvious that complex foods are vital and better. And also a balanced diet is. Reply @henrygreen7956 1 month ago Can you make nerves in the spine grow back? Reply @MugiwaraNoReemy 1 month ago Does this dude have a diet plan we can follow? 1 Reply 2 replies @user-xu9go9bm2v 1 month ago Let me tell you one thing - Chuck is a nice person Reply @kittypopcorn2347 1 day ago Solving aging might be the most important thing for humanity, if we know that we will be here for a long while we might actually start caring about this planet and the advancement of technology and science Reply @sabastianlove1286 1 month ago Would love to hear what this guy has to say about horticulture Reply @zack_120 1 month ago This is a serious human health topic. So everyone here should be in his natural state/look, otherwise it would be cheating the viewers, negating the very purpose here. Reply @justanime6504 1 month ago plz talk about titu singh rebirth case of india Reply @andrecarvalho9637 1 month ago I'm more interested to know if they can cure baldness 1 Reply @079Francvs 4 weeks ago As strange as it may sound, I have been researching Sinclair's work for 1 month, and as I have learned about this research I have been planning my life for 300 years or more (at first it was strange to imagine it), I have shown it to my mother and she even has considered the possibility of doing a second university degree once that pill comes out and she is 67 years old. I think I wouldn't have children until I get 150 years old or maybe I just wouldn't have them (preferable). lol It is not necessarily true that there is overpopulation or that people would not find meaning in life... people will simply have children much later or not at all, and will find new things to do as occupations over the centuries. 2 Reply @Kim_Miller 1 month ago You can some inter-generational epigenetic transmission in what is called the Post War Dutch Famine or "The Hunger Winter". Consider this, a woman gets pregnant in a time of famine. Like everyone she is suffering malnutrition. In her womb is her future baby daughter. At a certain time of the pregnancy the fetus will be developing ovaries and the eggs of a future generation. The baby girl is born and grows normally. In her ovaries are the eggs that developed in her in her mother's womb in that time of famine. As an adult she falls pregnant and her baby is born. That baby is the result of eggs that originally formed in a time of famine in the day's of the grandmother. That baby shows signs of what is called 'failure to thrive', a condition associated with malnutrition. So the experience of the grandmother effected the grandchild. A websearch of The Hunger Winter will give details of how the life of one person genetically effects future generations. 1 Reply @jeffpetrey69 3 days ago I’d like to volunteer for the blindness cure Reply @w0nd3rlu573r 1 month ago It's fascinating how we are approaching the state of reversing aging while also the time when we won't have any jobs to work at is closing in. Reply 1 reply @martelclark4613 1 month ago Let say a machine is made like the movie “Elysium”; would ppl matter the budget an accesses to this geno copy to start journey of a long life? Also would it be a problem far as this Genos being turnt on therefore would it be a bad outcome for that person keep making cells for that part of the body that geno suppose to be zombiefied? Reply @jozeaugust7703 1 month ago Ignoring the immortality, for blindness: this would only be applicable to those who became blind due to age and not born blind? Reply @anachronistofer 1 month ago (edited) Very interesting topic. I wish there had been more discussion about the practical and ethical considerations of potentially extending or even preserving life indefinitely. Neil barely and briefly touched on this at the very end of the program (overpopulation). Turns out the human species learns quickly but acquires wisdom glacially slowly. We're seeing the effects in full relief now regarding our abilities far exceeding our wisdom to apply such knowledge thoughtfully, carefully, and for the sustainable long-term. We're not wired up for long-term considerations, didn't evolve that way, which ironically is what might do us in. Speaking of glaciers, we might want to start figuring out how to re-freeze them along with millions of acres of permafrost in Siberia. We also need to come up with an alternative to plastic that biodegrades. In the big picture, we never figured out how to handle fossil fuels properly. Always short-term gain over all else. Give me a species that doesn't know what to do with it's own waste and byproducts (let alone care), and I'll put my chips on that species eventually killing itself along with millions of other species. Maybe there's a reason nature doesn't want everything to last indefinitely... Hmm. Note the cycles of the seasons. Humans are no different. Mr. Sinclair is very bright, but like most scientists he easily rationalizes his interests. Hey scientists: First learn coulda vs. shoulda before you carry on with your theories and research. Reply @gastonneal724 1 month ago My first epi thought was epidermis Reply @LaoZi2023 1 month ago Great interview! I can't help but notice the things on David's mantle, and then my eyes gravitated to those huge teeth, at which point I realized I am looking at a sabre-toothed tiger's scull! Reply @gastonneal724 1 month ago Only 30 seconds in, and you know who I’m thinking about already??! MS. HENRIETTA LACKS!! The first immortal life form, and remarkable WOMAN. 1 Reply @dno440 1 month ago Mister Sinclair can I buy the same NAD your father uses if so what company would I go through Alive by Nature Alive by science both cannot be found online now Reply @CraigDelist 1 month ago If there is a multiverse and if our "souls" or "conscience" or even that voice in our head when we talk to ourselves about "What is it I'm forgetting now that I came upstairs to get it?" goes at the moment of death to the next snapshot where we didn't die, but lived even a moment longer...we wouldn't know of that death. The snapshot would just become the video like our transfer pushed "play" and our next "death" would press "stop" so that the next snapshot... isn't that sort of already "living" forever? Consciousness without memory of past snapshots' endings? Or are those memories what we nightmared about in this or that snapshot? My brain hurts. In this universe. Reply @JesusChristDenton_7 1 month ago "And someday when the descendants of humanity have spread from star to star, they won't tell the children about the history of Ancient Earth until they're old enough to bear it; and when they learn they'll weep to hear that such a thing as Death had ever once existed!" —A wise Man 1 Reply @arjuna207 3 weeks ago It's a shame people still entertain Sinclair after the latest reveals about his research 1 Reply @user-zd1jb4id8p 1 month ago "epi" comes from Greek and means "on the surface", whereas "ipo" means "under" and "iper" meaning "above". epi+gio on the surface of the earth iper+gio above the surface of the earth ipo+gio below the surface of the earth (gi is earth, or ground) Epicenter, meaning the point on the surface of the earth, below of that point the earthquake started. 1 Reply @AllieAorta 1 month ago 34:38 “he’s freakin JEEZUSE to mice”!!! omg…. 1 Reply @standeman 1 day ago If we ever reach immortality, how much of life will we extend this miracle too beyond mice and men. Reply @americasgotseriousproblems2632 1 month ago Here’s some info on lifespan & life expextancy Reply @JayDillon-mm6yv 1 month ago Need to discuss DMAE in all this Reply @HulkSmash512 1 month ago One thing I always say considering the infinite mass of the universe, everything is based on knowledge. For example we as humans are looking for a way or producing or create an infinite source of energy with the materials we have on earth or at a way or storing the enerygy using a resource that is readily available and preferably non damaging to the environment. Its funny to think that, that thing we need could literally be an everyday object but due to our lack of understanding we haven't realised a way to harness it's full potential. We burn trees on this planet which releases energy in the form or heat and warm and fire but what if there was a fundamental property of wood that we just simply dont understand or know how to harness due to our limited understanding where as to some more advanced species, 1m of wood can be used for intergalactic travel. Crazy to think about what everyday material we have lying about that can be the source of infinite energy but we lack the understanding of how to manipulate or harness it. 1 Reply @ModdedGarage 3 weeks ago Sooooo never let these escape...ever Reply @Nibiru_-_Gen_Z_Warlock 1 month ago 13:14 Theyre referring to neuroplacicity here correct? Reply @j.h.181 1 month ago I'm interested in that investment opportunity... 2 Reply @Iamkayaky 1 month ago NAD precursers like NMN help renew cells. True or false? Reply @user-4in4nxDonaldRennie 1 month ago Kit Harington (the actor that played John Snow) is actually related to Sir John Harington the man that invented the flush toilet. Reply @sanketsbrush8790 1 month ago 14:55 where to get that same jacket ? Reply @estebandevile2706 1 month ago I remember nothing about not remembering how you re a Hero to me Neal Reply 3 replies @Noble3dprintersLLC 1 month ago Can someone comment on the Carbon 60 experiment regarding mice living 80-90% longer when C60 was ingested with olive oil? 1 Reply @TheGreatPyroWolf 4 days ago So it's like a MIDI file, it's different if you plug it into a MIDI player or player piano. Reply @AnonBinary123 1 month ago Wait...This is more on the peritent topic of Telomerase and Telomeres. Henrietta Lacks an African American woman. Although, wasn't the method using in Dolly the Lamb/Sheep? Also looking at cancer cells and their Telomeres' length, couldn't we reverse engineer with these type of cells to unlock and integrate it into Human Sapien Sapiens? (Forgive me for my grammar) This also worked with chicken embryology for switching genes on and off. Reply @seanharbinger 1 month ago I'd like to be the first to welcome David Sinclair to the Bond franchise! Reply @alexsisson3820 1 month ago We need massive social midset changes before people should live forever. We may not evolve much physically going forward due to medical advancements but we still can evolve mentally and death is a key part of that happening on a species scale. Reply @MartinGasparini86 1 month ago what about the thelomers of the dna of the cells they become shorter more division makes and errors occur... you could resolve that? Reply @darthsirrius 1 month ago Yes. Long story short, I do not want to die. Even if it applied only to me and none of my friends and family, as callous as it sounds, yes. Especially when we're talking about this idea of reversed aging, and essentially staying young-ish forever. Reply @eddiecampbell3514 1 month ago On another note my rat I've had and bred he made good babies .. the babies are all gone but he's still alive and kickin..about 3 almost 4 years old now.. I had rats for a snake and it just wouldn't eat that one rat and they would cuddle and rat kept snake warm when the heat bulb I had blew and had actually co-habitated for about 3 months before I finally gave rat a cage and kept him alive since that's his buddy now they are next to each other and continue to live . I now feed it frozen mice instead. Thawed out of course.. but both have been doing fine surprisingly. 2 Reply @qbitsday3438 1 month ago (edited) How dose consuming NMN affect us in our daily early morning with empty stomach with plain water? this is to Dr David, i have been talking NMN daily morning for the past 2 years Reply 3 replies @sodapop1850 1 month ago (edited) I always wondered if the diet question was based on where you were born. Like I was born in Massachusetts and there are fruits and vegetables and fish that a prevalent in that region of the world. Is my DNA pre-disposed to benefit more from the nutrients in the flora and fauna found in that region? Or conversely do things like tropical fruits benefit me less than someone born in the region where those fruits are found natively? Are cranberries better for me than a banana? Is cod actually better for me than salmon? Reply 1 reply @faceofdead 1 month ago (edited) Oh, our engineers are immortal for sure. To accumulate and manipulate that much information and calculate the hibernation, transport, terraforming and flourishment of the organisms, in order to close the cycle and become the engineers ourselves, takes (from our perspective) some time. And it is practically all baked in there, mutations, repair, self-destruct mechanism. Just incredible! Reply @eveningwiththekennedys9844 1 month ago Looking for Mr. Jingles mouse from the end of the movie The Green Mile lol. Reply @Robert-ul6tm 1 month ago I came across a video about a bacteria that is atleast to some extent responsible for teeth rot which is comunical. Think about Dr. Sinclairs work what about the mouse teeth? If he is rolling back age what about dental health. What is that saying about invasive bacteria generally as a driver of disease Reply @coldvaper 1 month ago If we cure aging we might not need to have a space craft capable of faster then light travel in order to get to other systems. I do hope treatments come available soon and its possible to peer review them in a timely manner. Reply @denisrivarola2387 1 month ago You know nothing Jhon Snow, except you got you higienes right. 1 Reply @maxhdez2847 1 month ago How can you have this conversation and not mention Bryan Johnson? Reply @titoub2008 1 month ago OK hey team, do this OSK help regrow teeth? Reply 1 reply @ColeAra 4 weeks ago The ads are intense on this channel Reply @inthehouse1960 1 month ago So does this mean we no longer have to say "I wish I knew then what I know now." or "Youth is wasted on the young." 2 Reply @ankiesiii 1 month ago There are a lot of ads in this.. Reply @danielthompson1882 1 month ago Can I be your first human subject where can I sign up Reply @High-Tech-Geek 1 month ago I was hoping for more concrete answers than "taste the rainbow" 2 Reply @user-qd2zk8zs1f 1 month ago I do not want to live forever, but I want to be able to given the choice when I want my time to arrive instead of biology setting the deadline. I want to see the most important scientific discoveries ever made like discovering life on another planet, taking clear pictures of exoplanets, and watching the advancement of medical science and space exploration. Death is an important factor of life. It is the ultimate source that encourages people to love family and nature as much as possible. Everything will die. The living on Earth, the planets, the stars, and the universe will one day finish the last chapter of reality. However, we all should be beyond elated and grateful of the bizarre and majestic reality that we live in. As a man of science, I am beyond curious of the unknown, and death is one of the greatest areas of the unknown. It is almost like a different universe. Thank you for reading this and live long and prosper 2 Reply @JohnnyMagorish 7 days ago "Humans we'll try next year". He's been saying the same thing for the last 5 years 1 Reply @kyrsid 1 month ago why does that remind me of Aldous Huxley, brave new world? Reply @Pain-ib7ot 1 month ago ya were is the backup copy! Reply @uk7769 3 weeks ago You are in my Top 100 Chuck! Hilarious. Reply @01Grimjoe 1 month ago 46:14 with all countries facing an aging population this not the worst time to bring up life extension. Reply @AnonBinary123 1 month ago At 6:28: Wasnt this also found in the Revolutionary War? Reply @alex84621 1 month ago They were saying that astrophysicists "are playing God" in the past as well. Curing ageing is very simple it's just that human brains are so attracted to death and away from immortality. Because it seems hard to be immortal. And also from all of the old animalistic mentality from past generations that couldn't even imagine being immortal. 1 Reply @markmc2163 1 month ago I think what we'll find is what happens with plants and clones. The genetics may stay the same but eventually some outside influenced disease will take over and eventually require a new seed. This is how evolution and adaptation works. If we remove the aging process and breeding process, will we ever evolve? Would it need to be done scientifically verse naturally? Reply @Ramschat 5 days ago I'm not playing god in my lab, I'm just replicating the processes of the miracle of life... xD 1 Reply @RFK_wait4_2028 1 month ago (edited) Wow, I remember reading the early research 20 years ago and getting really excited. After watching this episode I decided to review the research. . Guy named Brenner sums it all up. No wonder Sinclair couldn't get his research published in a journal and went straight to a (best selling) book. I appreciate Neil tossing some insider flak at Sinclair , but I think non scientists deserve to be in on the joke. 1 Reply @TaimazHavadar 1 month ago ماری جوانا از جوان نگاه دارنده های اصلی است Reply @ceelosvee 13 days ago Look at Ichiro Suzuki who played baseball who is the second oldest player to play since 1901 Reply @anthonycraig274 1 month ago Great, now I have to do research into Brad Stanford. 1 Reply @thetroublemaker65 2 weeks ago Neil deGrasse Tyson is a national treasure! Reply @ayinke4551 1 month ago (edited) Very interesting discussion. I am glad Neil asked the question I wanted to know, and that was if you are reversing the age of mice, why are they dying? Bryan Johnson is currently spending millions of dollars each year biohacking his body to try to reverse age, and (in my opinion) from an external perspective, it is not working. Whereas Chuando Tan actually looks like he has discovered the secret to not ageing, and he says it is exercising and eating a sugar-free diet of meat, eggs, fish, and poultry. The opposite of Mr Sinclair's recommendation, but Chaundo Tan is 58 and looks 28... . Reply @shreyasted2392 1 month ago chuck is our real MORTY Reply @ThewiseOrangutan 1 month ago great video Reply @SkipYearSix 1 month ago Save us David! Reply @bryanamadorakathementalist5445 1 month ago It blows my mind that none of these "experts" talk about emotions which is the outside environment of the cell and changes your gene expression. That is why stress causes illness. Any negative emotion causes stress. Reply @capgains 1 month ago Let’s push for Sinclair debate Reply @JesusHernandez-qn8ck 1 month ago I have been following David Sinclair for a while and the first thing I noticed Is that he got botox, His face looks different 2 Reply @GMS_MCMI 1 month ago (edited) Serious question (is someone from Startalk reading the comments?) How do they know the mice are reversing aging due to there being a "Back-up copy of the software" rather than, the dormant stem cells are being reawakened and are reversing some of the effects of aging they artificially put the mice through? I ask because there are a finite amnt of Stem Cells, so once those are used up, that's the end of that. The organism can't extend life indefinitely, only reset and add some more years on. I mean, if they add 20 to 30 years to anyone's lifespan that would still be amazing, but they are not creating immortality. The question is, how far can you make those stem cells go? Reply 1 reply @ArticBlueFox96 1 month ago I wish that they asked Sinclair about things that he was wrong about and what he learned from that. Reply @disciple1010 13 days ago If we all used soft filters lens in video , we all look young like David Sinclair lol , who’s ideas to bring this guy lol 1 Reply @olympiakos7Peiraias 1 month ago (edited) If you were about to live forever, at which age you would like to stop getting older? I like 30. Not younger nor older. Otherwise, imaging living permanently as a 90+ years old dude... 2 Reply @dustysoodak 1 month ago There is a book called survival of the sickest which has done good sections on modern epigenetics. Reply @MichealClark-pv9fw 1 month ago How many years will it be before we stop aging. Reply @demontaboone2871 1 month ago Serious question,so if I dig a hole from the top of the earth straight down to the bottom and then dove in would I come out the other side head or feet first???️ Reply 1 reply @DC5Brandon 1 month ago (edited) Even if humans can find a way to live forever, I think our emotional capacity would make it more difficult over time for our sanity to do so. The comment made here that one would want to extend the life of a pet is a good analogy. Unless you can extend the life of everyone around you, the constant cycle of love and loss for pets and people would eventually wear an immortal down. It's one of the more interesting aspects of sci-fi and fantasy fiction involving immortals that I find compelling and the morality of using epigenetics we may find ourselves debating soon. Reply @QuantumBraced 1 month ago David is 54? He does legit look 10 years younger. Also, damn Chuck came prepared for this. Reply @user-tu9ox4hj9g 1 month ago Would you want to live forever? Whats interesting. I read many comments stating they would reject living forever. However statistically speaking the religious community craves everlasting life. Which group is composed of five billion humans. Thats 84% of humanity's population. I think people are missing the facts that you'll still be with your family and friends if they undergo treatment. Also you will stay at a healthy and youthful state. Goodbye joint pain and losing performance in mobility. And most of all, if we globally harminoize the nations. Earth can become a paradise. There's so much to live for why let an automatic process dictate when you will die if we have the chance to choose. 2 Reply @MrMerlinsMagic 2 weeks ago What about the minds of these people? Isn’t there something to be said about how time and experience tend to fix people’s thoughts. Wouldn’t that be problematic? Reply @champsfirst 1 month ago Anti-Hayflick Limit cocktail anyone? Reply @SoulHackerOfficial 1 month ago Anyone watched In Time? Reply @nancycorrea9319 1 month ago Con solo escuchar sus risas, he rejuvenecido como 10 años adorables Reply @0x0michael 1 month ago He looks like an Apple Vision Pro Persona 1 Reply @angelangelov7869 1 month ago Доктор Тайсън магазина отзад има вход, охраната е на 30, метра от магазина,, трябва да се внимава,, Reply @sabastianlove1286 1 month ago Wish this guy could cure my Ehler Danlos Syndrome. 1 Reply @dpsamu2000 1 month ago I have a cat that is litterbox trained. All her kittens used the litterbox as soon as they could get in it. So they raised mice to be obese. The offspring were obese also. I'd have to see the methodology. Reply @user-we3yg1tx4u 1 month ago Could you do this subject again with Dr. Michael Levin. He probably is more used to this topic than anyone else. No disrespect to these gentlemen. Reply @BonBonBonni 1 month ago Amazing! I think in 30 years, all of us will take these pills. 2 Reply @gaziahmed2103 1 month ago Timon and Pumba combo never fails Reply @stuartsmith8155 1 month ago I VOLUNTEER AS TRIBUTE !!! Reply @gsam3461 1 month ago Ummm is this guest the voice from the now famous Claude 3 video?? Reply @ginnyjollykidd 1 month ago If pancreases were able to be rejuvenated, that would help so many diabetes type 2 patients. Diabetes type 2 is caused when the pancreas wears out. Like gray hair and baldness, it's pretty much not our fault. How about heart disease? Glaucoma? Macular degeneration? These four things and diabetes type one are some crucial diseases of today whose cures would change quality of life immensely. 2 Reply 1 reply @CujoHyer 10 days ago Oh, my god. I lost my vision 3 years ago after being born with retinoblastoma. I had vision in my right eye until I was 40.. I will HAPPILY subject myself to a Human trial for this medication, and be the person who went blind and can be brought on this podcast to show off to these guys! What do I dooooo to be that person? I'm on a Screen Reader writing this. My eye is so freaking damaged by radiation and the scars of cancer treatment. I think I'm the ideal candidate for this! 1 Reply @aquahood 1 month ago Play for YouTube premium! Reply @badlandsdrivetv2415 12 days ago Meditation has shown to increase the length of telomeres, proving that stress reduction techniques increase the lifespan of the individual. Reply @GhostSal 1 month ago David is looking younger and younger, looks like someone had a breakthrough that they aren’t sharing! Reply 1 reply @HarryNicNicholas 1 month ago i think the most important aspect of this is, will the "ten years younger pill" be available to everyone? and what will happen when people live even longer, we seem to be having an employment, er, crisis as it is. i'm all for living longer (if i can remain fit) but unless we get to mars soon we're going to have problems. 1 Reply @elizabethstafford984 4 weeks ago Are scientists using cells from younger Specimens integrating with older specimens in order to rejuvenate? Reply @aquahood 1 month ago I actually have the aptitude and the ability to be a medical doctor and I always wanted to do but my family manipulated me to come what my family had always been which was a lawyer and I regret every day of that decision I know one of his colleagues at Harvard Dr Ichiro kawachi. He's the founder co-founder of socio epidemiology and he's talking to sort of the same thing about how we design our cities and how to design our cities to intervene upstream before illness progresses. Reply 1 reply @sadravin1 1 month ago im only 10% through this video; but if aging can be turned off, would light speed space travel matter for exploration of the universe? Reply 1 reply @Docswavestranslucent 1 month ago I definitely enjoyed your shows. I do have an idea that came from this. Also I don’t have no background or knowledge of any of the above. I do have a comprehensive understanding how I think everything works in my head. So I used ai to break this down to me like kindergarten so I can make sense of what I’m thinking of this idea. Also I’m not articulate in my wording or language. If you bare with me I would be appreciated of you. The following is what I ask of the ai to help me with Reply 12 replies @tinaankaradesigns254 1 month ago does blood transfusion affect genetics Reply 1 reply @RylzRiles 1 month ago Could you imagine they "cure" aging, and I'm having conversations with my great great great grandkids! Reply @33interzona 1 month ago I can't believe that I'm alive to hear a scientist say "Lammark was probably right". I thought that it would have taken a hundred more years. Reply @dno440 1 month ago Fun fact my wife and I both took NAD and nmn for over 10 years since he was on Joe Rogan Experience she became pregnant a few years ago again and we had three healthy kids she was originally told would not be able to have kids Reply @MrGriff305 4 weeks ago (edited) 19:20 ... I normally wouldn't believe this type of thing, and David is known for making claims that go too far. That said, he's a Harvard researcher in this field. If there's any chance this is true, it's absolutely astounding. 19:20 1 Reply @HeliTom84 1 month ago My spouses grand mother is 103 and never been much sick and still going strong and lives by her self her in Norway. she’s smoking a pack of sigarets each day, at least a couple of bottles of white wine per week, lazy and a little over weight. She’s been to the hospital two times in her life; when she was borned and when she gave birth to her son. Reply @jameslowellblakenship2192 1 month ago What's the deal with Japan's Hkdc1? Talk about sea life. That brings up a C15. Reply @Vshamann336 1 month ago 5:18 at 38 years of age I have been saying for at least 20 years. That dying makes absolutely no sense. Our body has everything it needs. Why does it stop making it? Nothing about it Makes sense. Not even survival makes sense. So it would be better for me to pump out children then for just me to survive I think not. I think populations get out of control by using that if we're going to say well. This is how we've evolved to survive and pass on our seed. I don't think that's all there is to this. But yeah it makes no sense so I'm glad you guys are bringing some sense to it. 1 Reply @michaelgonzales-smith9714 1 month ago My god, it's an amazing time to be living in. Coupling this with the emergence of AI, we are truly living in the future. 1 Reply @SamSam-qm1li 1 month ago Chuck seemed more serious about living longer Reply @donbazukon9620 1 month ago The question could be, do we want to continue this particular life forever? Or being able to not forget our true mission when we transcend? Reply 1 reply @user-em5qh9he6e 1 month ago Maybe we could worry about increasing the quality of life for everyone on the planet before we worry about ourselves...it seems to me this will only increase the unbalance that we've done huge steps in decreasing for the last few decades... Reply @atillaordog4305 1 month ago I live in Transylvania and tourists always ask me if I met a vampire. But in my 234 years on this earth, I never met one of them. 1 Reply @timtruett5184 1 month ago Forever is a long time, but a few thousand years would be great. If we had to be concerned about what type of world we would be living in 500 years from now, we might take better care of things. Reply @huldu 2 weeks ago If you can reverse aging how does that translate into your ability to reproduce if you were unable due to aging beforehand? Reply @Dcjoe94 1 month ago Please address what david jhonson is doing and if it's legitimate of not Reply @madgoatsnorway6690 1 day ago “Jesus to mice!” Lol. Love David Sinclairs work. Reply @phfinlayson 3 weeks ago NMN is a supplement an David Sinclair is now trying to get the FDA to have it banned as a supplement so that he can turn it into a medicine. 2 Reply @ryvyr 1 month ago A wonderful video like this is ruined with interruptions well into video - people seem fairly stretched for dollars at the moment, yet plenty of us will gladly watch non-adsense reels if placed at very front/back/both. Reply @Partofplanet 1 month ago 23:47 1 Reply @seanwhitehall4652 1 month ago Gary is 63 and David is 54. David is doing a good job being walking anti-aging proof. Reply @MrAndreybond 1 month ago I think the most important thing was said the last. There aren’t enough space on earth for people to live prolong lives. Normal people wouldn’t be allowed access to such medication. Reply @Hunterxii 1 month ago 10$ to cure blindness US medical system... sounds like that should cost 125,000 2 Reply 1 reply @ignorasmus 1 month ago Anybody who wants to live "forever" on earth or in heaven, has not truly contemplated/ understood the ideas of Infinity & eternity. The Hindus have an interesting philosophical approach to this. In Hindu mythology, many humans & daemons tried to earn immortality through various means. God took one form or another and struck them all down one way or another. Only one person called Ashwatthama was ever "cursed" with immortality because he killed a baby in a womb. One more person Bheeshma in the same Epic called Mahabharata, was given the power to decide the time of his death because he was considered to be very wise. He ended up living too long and badly regretting his decision to keep postponing his own death. 1 Reply @estebandevile2706 1 month ago How can media Just change someone face after some error moment. Reply 2 replies @ntwadumela1777 1 month ago 17:37 lol I wanted to hear him lol Reply @TheBavaNeche 1 month ago We will do Far More than what He did.....He Said So! So by definition....We are Gods! Reply @josephstandish599 1 month ago John Snow! King of the North! 7:10 1 Reply @Nightcorebests 2 weeks ago In Ethiopia there is a woman who doesn't eat and drink water. She is famous for it too.Many doctors confirm that there is no food in her intestines.... So investigating people like her might also help to understand how our bodies work... I hope you can look at the matter and I would like to hear from a researcher what exactly happened to her body ... She stopped eating for 14 years or so if I am not mistaken.... Reply 2 replies @Amalgamotion 1 month ago Friar Chuck came in so hot he sat there ablaze. Gary lit up too and the connection was digital. Best show on the interwebs. I know that people kinda avoid this question because I like to ask it. B/c I find the answers surprising. But I would love to know how long you'd like to live for? 1 Reply 1 reply @baronblair5811 1 month ago Death is inexorable and cannot be denied Reply @thomasrosendahl2783 1 month ago Bryan Johnson might actually live forever, if the trajectory of his Blueprint protocol further improves. Reply @butter-elvis 1 month ago Hydra (genus) do not appear to die of old age, or to age at all Reply @b.ambrozio 1 month ago It's great to see 2 of my favourites scientists together in the same video! Thanks for that, Neil & David! Reply @natevelar 3 weeks ago I wish he would have commented on Plasmalogens and their natural benefit to longevity and cellular health. - https://en.wikipedia.org/wiki/Plasmalogen Reply @vmura 1 month ago accept your destiny Reply @user-bi5ft8wx8t 1 month ago So I have to be vague but I once worked on a RADAR... it was observed that when individuals that worked on this RADAR whom participated in a pregnancy the resulting child was a female... moving forward after these individuals were no longer exposed to this RADAR they would have male children. If Doctor Sinclair would like to know more I might be able to expand on this phenomenon. Please feel free to contact me. 1 Reply @alexf7414 1 month ago Chuck is so funny Reply @Raulikien 6 days ago Interesting but no talk about future long term consequences of this or how everything changes if we all live forever? That's disappointing Reply @emmanuelweinman9673 1 month ago Looking at death as a disease is like looking at life as a problem. Reply 1 reply @greggdonnellable 3 days ago My main concern is that this would be an exclusive tool available to the ultra wealthy, allowing them to continue amassing incredible wealth for hundreds of years while the poor and disadvantaged would see fewer opportunities as the wealth gap grew exponentially. Reply @ramcymendoza2381 1 month ago I think instead of asking for $10 for the pill, I think they should ask all participants what they will do for the aging and the rebuilding of Earth first. Reply @DaleBEATBOX 1 month ago If you could reverse the aging process in humans would it also reverse your memory to the corresponding "back up age" Reply @MikeJones-wp2mw 1 month ago If cells divide forever without regard to telomeres you eventually end up with tumors and cancer kills you anyways. If people stop aging and dying of old age we will stop evolving. The young that are born will never grow up because their parents will always be around I'm almost 40 and my grandparents are still alive. I've never been under any real pressure to succeed because in the back of my mind I've always known that my family has enough resources that I eventually will fall in my lap no matter what I do. I have had entire careers, but never really saved anything. No retirement plans at all because sooner or later I'll be worth millions of dollars. I'd rather have my grandparents. I'd rather see them spend it on themselves and enjoy it, they earned it. But we can't even get my grandad to buy a new car. Yes, he still drives and so does my grandmother and they are in their 90s. I know the best gift they gave me is their genetics, I could easily live to be over 100 except for some reason I feel like I'll die a violent death. No worries, I'll take a few of them with me if that's the case. I have reproduced, that's the true way we live forever. All these people are chasing a pipe dream, the human mind can't survive the world changing. People start going crazy, my grandma was so ready to die she talked about it all the time. She started giving away her things. It was sad. But she told me so many of her friends were gone already and the world had changed in ways she didn't like. It wasn't what she was built for anymore. Her ways were not the ways of the kids today. A rare few people can constantly learn new things and change with the times. We aren't meant to need to do that. Reply @Ben-pd2bx 12 days ago If you want the mouse that hasn't died yet (34:13) then I can almost give it to you, but not in Sinclair's lab. Check out the work of Harold Katcher and Steven Horvath, who injected a young porcine blood plasma fraction with high exosome content into middle aged rats and IMMEDIATELY broke the record for longest lived Sprague-Dawley rat by about a month (the previous record holder had been genetically tampered with too). Of particular note, they stopped giving the rat regenerative treatments before it died, so it's possible it could have lived longer. Google "Harold Katcher and Sima the rat" and you can read about this. We are going to beat aging, sooner than many of us think. Reply @aquahood 1 month ago It's going to be just like that movie with the Ethereum Reply @JohnnyElectronaut 1 month ago I've always thought about how Socrates lived to 71 and he didn't even die of old age. Reply @shalinimiglani6226 1 month ago Greetings, aging is a process. It is cyclic. All matter comes with an expiry date. Aging is not a disease. The cycle may vary depending on the friction experienced. Really can have a good discussion. Reply 3 replies @GinaCarmichael-nd2pt 3 weeks ago I think you have answered the effects, susceptibility to diseases as to why the haplotyte of that region should be represented by that cultural region. Oh yes, "Grandmother Jemar President Ron Reagan has been shot!". Telemeres ok longevity. Reversal of aging is a equilibrium constant maximized. Reply @paulanderson7628 1 month ago I'm. Stunned. Is this something tangible that i can believe in? This looks and sounds real. Reply @Blaxjax21 1 month ago Ah, back to the age of Vacuum tubes and punch cart computers. Yes I am that old Reply @TattooedGranny 1 month ago (edited) Turritopsis dohrnii. Flowers for Algernon. Reply @sophiafunworldatthepark6740 1 month ago Live forever should be an option but live a healthy at old age is the option. Reply @BigDaddyDax 1 month ago George Burns Reply @thalastboss01 1 month ago SEND THE PILLS MY WAY. ILL TRY EM OUT =D Reply @johnpublic168 12 days ago Read his book he does modify his behavior Reply @owlcarnival 1 month ago Would we be able to go back to the best version of our bodies? Reverse aging? Reply 1 reply @TorQueMoD 1 month ago I have to say that I feel so sorry for all the people who die on the edge of these medical advancements being available to everyone. Reply @TheToaxmc 1 month ago Sound quality so bad can't watch Reply @TurretHead 4 weeks ago This guy kinda looks like Wesker from resident evil Reply @Emilyjacksonmidwest 1 month ago Talking about is mitochondria Reply @TheArtofMentalAlchemy 1 month ago Dr Bruce Lipton explains Epi-genetics on London Real The Biology of Belief Reply @shaquangreen8832 1 month ago I feel like we are aging slower If you look at the pictures of people in the 80’s and 70’s they looked 40 when they in the ages 25-30 Reply 1 reply @myusrn 1 month ago When people react with uggh / yuck to the idea of sticking to vegan nutrition it just represents someone who doesn't realize how great tasting whole food plant based nutrition can be. They just immediately think boring salads like the crap restaurants sell smothered in dairy, aka ranch, or olive oil. Reply @karlgoebeler1500 1 month ago Hallmarks ? Is that another word for Key indicators ?? Reply @kx4532 1 month ago How to get non-fake NMN. Reply @KeanuReevesIsMyJesus 1 month ago Chuck is so sharp. David: “I’m not playing God.” Also David: “I’m just doing what embryos does.” Chuck: 1 Reply @dpetersontube 1 month ago "From the light we get darkness...and from the darkness, light." Welcome to the episode where Neil becomes Chuck, and Chuck becomes Neil. Reply @Vshamann336 1 month ago I'm hearing 24:02 Is that people living longer may naturally have the effect of less children, thus helping curb our population problem by getting healthier...... Reply @kira2606 1 month ago I wish Dr Tyson had pushed back a little more or perhaps brought more skepticism to the table with this guest. Reply @dougg961 1 month ago Risen Reply @Dron008 1 month ago Mindblowing. Could AI make it even faster? Reply @tesfayteklu5420 1 month ago How about the socio-economic effects of reversing aging? Wouldn’t the world be in a complete disorder as a result of competition for resources? Reply @inthehouse1960 1 month ago Is the inherited DNA related to generational trauma? Reply @pondboy3682 1 month ago I've seen an interview of someone cured from blindness by eating only red meat. Reply @jamesrmore 2 weeks ago For those who can afford it? Reply @user-iz9zb6zh4f 1 month ago Imagine some future time. And the parent is telling the kid why great great grandma is not around anymore. And the parent explains people used to grow old and die. And the kid is like really. Reply @steezybrahman 1 month ago “Is aging a disease” is basically the same question as “is dying natural?” Reply @dumaskhan 1 month ago you all remember the movie Elysium with Matt Damon? Let us hope the Richest among us do not monopolize this research (they probably will). 1 Reply @yousefalhaboob148 1 month ago David Goggins at year 2400 " you don't know me boy" Reply @BobLinton 1 month ago " I'm not playing God in my lab." LOL! 1 Reply @walterabernathy5663 1 month ago There's a book out called the right diet for your type If there is that people digest food differently depending upon their blood type My wife had A blood and she cannot tolerate orange juice she would find it up with me it was healthy I am type o. Reply @RicardoRMartinelli 1 month ago can you heal diabetes and cancer? Reply @micahlallison4691 1 month ago (edited) He who lives forever is forced to watch his loved ones die, slowly becoming a future villain - as I twirl my moustache 1 Reply 1 reply @GinaCarmichael-nd2pt 3 weeks ago Society automatically thru stress will act upon aging. Including breaks from reading of that DNA or event. Societal adjustments thru medication may become a farce if problem solution complex cannot be found. Injections of society, economics must be analyzed for specific kinds of things. Spiral economics thus has to be core values of the income curves of primitive ancient cultures in order for equilibrium constant maintained. Yamannuki percentage of influence in this world is the sustenance. Aging brought on by weatherization must be understood and released ever so changing process. The Read is the transcription. Matter of life. Reply @ebt12 2 weeks ago This is the first time I am aware Neil DeGrasse Tyson has dealt with the subject of fighting aging, and it is wonderful to see. The idea aging can be brought under medical control is becoming more and more accepted amongst medical professionals, with the knowledge of why we age being better understood. I hope more people are brought on to the show to talk about it. Reply @kingdavid3066 1 month ago ancient cosmic wars were already fought over this, and humanity is doomed to repeat it. Reply @jwtodd82 1 month ago NDG, gotta let you know you're giving off a serious Bill Cosby look in the ST+ plug. Heads up you may want to do a wardrobe change Reply @johnfitzgerald8879 1 month ago If it's not cured in the next 20 years, I'm in trouble. Reply @AngelCordero-wz3xc 1 month ago At one point it was said that animals age as well, not all of them. There is a jellyfish that is considered immortal. Reply @hangbrand8199 1 month ago OSK 15-19-11 Reply @tekmepikcha6830 1 month ago Many of these Star Talk videos will become resource material for many young research scientist! 1 Reply @JustJumump 3 weeks ago Bio medical Gerontologist Abrey degree was all talk about this in 2010, yet now he not talking, and last I heard he said looks really really much more difficult than I thought. Unless he found something.,and wa forced to keep it under rsmps. I read his book, Ending Aging". There " " "many" incredible experiment plans, yet as usual given the history of 'man' they disappear. And u hear nothing more. Back to the dark ages is the best hope. Reply @rachetgear 1 month ago Reply @brycehuff 1 month ago So basically epigenetics are impacted by diet, exercise and environmental stress. So if every day I eat healthy, exercise, and meditate I can improve my longevity? Where have I heard this before? Reply @xena7588 1 month ago Whoever doesn't want to live forever don't , aging is a disease and there is humans like me that want to experience the whole reality whilst not being time limited. Reply @MillsElectric 1 month ago I think they’re forgetting a key point. The government would never allow that technology to live longer to come out, at least as of right now… Reply @fordboyzzzz 1 month ago imagine how over populated we would be if people were imortal Reply @AliHussein30605 1 month ago Reply @EnchiladaBoredom 2 weeks ago I cannot host this I'm afraid. I\You might be needing to go to shell of Chevron and see if your chances are stuck on a snack label. Reply @hollandanish5557 1 month ago Things we need to think about as a species: - immortality who and who decides - the rise of AI what kind of regulation and by who - environmental degradation who is responsible and what do we do about it So that's the dance card. Are we worried yet? Because as a species I'm not sure we have a great track record so far. Side bar: I don't feel like I'd want to live forever but I'd love a little Time Tourism. Wake up every 200 or so years have a gander at whats going on and back to sleep for another 200. I'm just curious about how things turn out. Reply @davidelfirium4957 1 month ago What would be the Epigenetic effects of Racism? 1 Reply @adonixp 1 month ago That dude looks younger every time I see him. What is he taking?! 1 Reply 1 reply @mikenn1734 1 month ago David Sinclair looks much older than he did a year ago Reply @nathanring3046 1 month ago This is great news but what’s the point in living forever if we don’t have a sustainable way to live with our world forever? Reply @shanedetsch 8 days ago Is it true the heart beats about 2 billion times and then is done e.g. humming birds live less years than whales because their heart beats faster do we need to reverse aging and replace parts? Reply @pinguin00o73 1 month ago I knew it dna works like a terlist to see which stran is used most Reply @ubergeeksteve 11 days ago Ok, so we are already in an overpopulated state.. now we are talking about rebooting 30 years, every 30 years? How are we going to choose who gets this? Would this be a, for the very wealthy only? Lots of questions come to mind when it comes to immortality. Reply @ZoroasterIII 1 month ago Maybe invite a co-host with a relevant background and ask real questions. Reply @MikeG-js1jt 1 month ago America's song and dance Astrophysicist ...... him and Kaku America's song and dance Physicist should get together and have a vaudeville tour......... Reply @lamontwatson6967 2 weeks ago Either chuck is on the ball or he's got someone telling him what to say. I think he's absorbing some of Neil's intellect lol Reply @IAmTheJManOfficial 1 month ago Don’t you hate it when a flashlight isn’t a lightsaber?… Reply @zuzupetals4794 1 month ago I wouldn't want to live forever.... it would make life less precious. And you would have no reason to get anything done, you could always put it off until tomorrow. 1 Reply @alswedgin9274 1 month ago There is the philosphical debate: 'Nature vs Nurture'. My single simple answer to that is 'Nature+Nurture.'. Reply @2gj906 1 month ago Certain jellyfish species and Greenland Shark need to be studied further Reply @johnnycakeslim 1 month ago This concept of rejuvenation is being discussed on YouTube without the investments of drug companies looking to package something to profit from. Many discuss rejuvenation with nothing more than changing our mindless behavior into mindful behavior like Professor Ellen Langer out of Harvard. Dr Joe Dispenza is also making headway with measurable degree with his meditations. Reply @tommycollier9172 1 month ago Too many commercials Neil Reply @doctorwhy6504 2 weeks ago I'm not sure about living for thousands of years like a tree, but could you restore my auditory nerve so I can get rid of this doggone Tinnitus? Reply @arxmechanica-robotics 1 month ago David Sinclair looks younger every time I see him. Dramatically so. Reply 2 replies @jayelder9725 1 month ago Look Likes Cocoon is going to happen but we are going to be the aliens . Reply @frogpaste 1 month ago "We're experimenting on dogs." John Wick has entered the chat "We think we can help them to live longer." John Wick has left the chat 1 Reply @LittleRedDorrit-lc5cm 1 month ago Way to go Chuck. Can you still walk with that heavy load of new respect? I foresee Neil telling the jokes and you hosting! Reply @dopamineaddicts262 1 month ago leaders of bactirias talking abt thier cousins and Pantheraneans to define in ur language, shud listen and feel how low few can get. best episode keep it up wit rat talks siuts ur kind Reply @Muzick 1 month ago Maybe I'm seeing things but it looks like there's something going on in David's face. To me he looks "younger" than when I've seen him in the past. Specifically around his eyes and nose. Reply @YouTubeOGEhm 1 month ago If we reverse aging could we possibly see a dangerous effect like, & bare with me here, Benjamin Button ? 1 Reply @justtired123 3 weeks ago "Hes Jesus to mice" Im dead! Reply @CreativePublisher 1 month ago David Sinclair is not only an scientist, but also runs several biotech companies. He sold one for $750 million. Reply @Babesinthewood97 2 weeks ago I wonder if this could also mean that if you for example are studying maths, biology, art, humanities and languages etc, basically learning lots of skills, plus eating healthy plant foods and exercising and creating a non toxic environment both physically and socially, prior to falling pregnant, then maybe it will positively affect the epigenetics of the foetus? I mean over time during your life, not just during your pregnancy. The latter sounds awfully stressful. Reply @walterdayrit675 1 month ago Great just what we don't need.....immortal mice. Reply @ValterUngerson 1 month ago I thingk air atmosphere makes life age. Reply @Shamwilder 1 month ago David Sinclair actually looks different, maybe younger than his older appearances on Joe Rogan. Reply @Ken19700 1 month ago Getting the price down from half a million to 10 dollars just means that it will cost the pharmaceutical company 10 and the rest of us 100,000. Reply @Russia-bullies 1 month ago (edited) As the fact that DNA has back up copies means nature does & did things without reason/the original DNA creators weren’t smart enough to forgo backing up,I disbelief the fact. Reply @bene88597 11 days ago (edited) David loos different man saw him last time 1 year ago his Eyes and the proportions look different Reply @Montycarlo10 1 month ago I mean if we being real no ones living long regardless of what we do. All we’ll be improving is the biological aspect of the bed to stop the aging process, and as morbid or blunt as i think it’s but a human body has its shelf life which you might try to extend but eventually it comes to an end. Now as for the soul whether we see it or not it’s time is most likely set we see people die young/old, naturally or unnaturally, healthy or sick, accident or not so in the grand scheme of things deaths is already set for us all and it may come in different forms but it comes nonetheless it was most likely set before you even came into existence, well my thoughts anyways don’t know about others. But immortal mice though will they out live us…. Reply @demetriusharris1268 1 month ago the key to space traveling Reply @Broockle 3 weeks ago Amazing if this is true. But I've listened to a lot of quacks and frauds over the years Reply @jessewest2109 2 weeks ago Bret weinstien is the guy to talk to about this. NDT should not be commebting on biology with authority. Hes an astrophysicist. With not much published. Reply @silviavalentine3812 1 month ago 34:47 I would actually like a mouse that lives forever! Then i can have a longlasting friend! Reply @XxxXxx-gd6lq 1 month ago Sinclair's left eye....what happened? Reply @TheStakashi 1 month ago What about the jellyfish ? Reply @SelfimproventandDevelopment 12 days ago This is insane I already always thought my hard work ethic in life and monster stamina brain came from my dad that did the same thing lol crazy crazy Reply @cheese1234b 1 month ago I would just like to point out that Neil pointed out that MJ is the basketball GOAT... debate over 19:32 Reply @edenwilde2719 1 month ago Doubling the remaining life of a 25 month old mouse expected to live to what 27 months? I'm with Neil a 29 month old mouse isn't blowing me away yet. Reply @veredk4384 1 month ago This is not the first time I'm thinking this, looking at Sinclair on camera, is he using a face filter?... Reply @saammahakala 1 month ago No "human" could live more than three centuries without going mad/madder! Reply @alessandrodimeo6570 1 month ago (edited) Neil was probably boiling inside, and for good reason. He must have been pushed a lot to have mr. Sinclair on his show. Neils philosophy is the one of wonder about life, mr. Sinclairs is to be clinging to it. Reply @1fires1 1 month ago My eleven yo Niece said that by the time we figure out anti-ageing we'll be all dead. I said Oh yeah good point lol Reply @user-of7tt4ju6j 3 weeks ago I am waiting for anti ageing medicine. When it will be available Reply @JuanGarcia-zy8yw 3 weeks ago That’s what meditation and stillness can do for you that’s what yogic systems are about about … and that’s why it is better to eat less … your body has abilities you don’t know about Reply 1 reply @StockGenius152 1 month ago As Neil says, show me the animals that live longer than before, he can’t 1 Reply @Voxshadow73 1 month ago So, you mention eyes. What about teeth or hair? Reply 1 reply @lonewolf5969 9 days ago Well to be honest people might not believe that mice has a closer DNA to humans Reply @user-rp1lq9ws5l 1 month ago Dnp 2.4 would help with injury’s Alzheimer’s and longevity along with starving cancer and of course its original use Weight control just gotta remember its half life and prescribe it for a shorter duration to avoid overdosing Tony Alan Ratliff I’m not a doctor this is me asking if it would lol any doctors care to answer Reply @clearlyaudible 1 month ago 32:18 - Can You Cure Aging? Reply @pgc6290 1 month ago Who knows after a couple of hundered years we might live in a computer. So saying that we might need a different planet and all for sustaining people doesnt really make sense. All we need is to ask if say can we sustain people without dying for next 200-300 years. Thats a valid question and if yes, we are good. Just imagine the technological advancements in couple of hundread years, especially with a handy god called ai. 1 Reply @Leroy-gg5qg 1 month ago Reply @GlacialRidgeHomestead 1 month ago Neil how come you always look sleepy? I’m a fan. Just curious if you get enough sleep. Reply @jensonee 1 month ago i'd like a second go around. Reply @Tuesdaysdead 1 month ago Well there goes the theory of we have no free will if we can change it.... Reply @crimsonsnow01 1 month ago Be kind, rewind. Reply @Steevee5k 1 month ago The longer you live, the more time is there to waste. Reply @classicarl1795 4 weeks ago It boggles my mind everyday that people are either not aware of this or not talking about it. This technology is one day (not so far away) going to make us eternally young. Seriously... who cares about AI or other technological advances when we have this coming our way. Reply @Philusteen 1 month ago What is Sinclair selling today? 2 Reply @trappedkitty5335 1 month ago I hope they never go public. Answering to shareholders is what ruined Cepheid. Reply @joppadoni 1 month ago (edited) You can reset any cell in to a stem cell? Does anyone realise what that means.. Why is THAT not massive news... Reply 1 reply @ReelLife97 1 month ago Can't wait for the anti-glaucoma drug next year. If it does work, it'll be a miracle. Reply @Navneet2026 1 month ago There was this I don't know what but 10% ruel that plants get energy from sun 10% it consumes and from plants we get 10% of that 10% and doing so we consume that food to generate the energy Now body is a machine the more you use it the more it ages so instead of generation of energy by consuming food we can try this direct energy from sunlight. Reply @HouseGuide 1 month ago Why must there be such a long waiting time before the public can have access. I know people right now who could desperately use the gene activation therapy that will repair their vision and will be able to pay the half million for it. If it works, please offer it to the public now. These people cannot wait 5 or 10 years. Reply @user-hs3rp6ri4x 1 month ago (edited) Isn't the mechanism of aging much easier to find in a primitive organism like yeast which has a much shorter life span? Here is a probable approach. Take 10 yeast cells. Have second generation of all. Keep the second gen from those parents who lived longest. Repeat this n times and we have a yeast cell with 10 times longer life span. Now compare the cell contents of this super yeast with a normal yeast. Reply @tugcebalta86 1 month ago Do you imply that Keanu can fly except dream? Reply @RichardMitchell-nk9ec 2 weeks ago Yes plz eternal life plz Reply @shanedetsch 8 days ago If we increase the percentage of oxygen will that extend life? Reply @vanikaghajanyan7760 1 month ago 16:30 Aging is an irreversible cosmological phenomenon; and comes with or without wisdom. P.S.The asymmetry of time actually implies the accumulation of time, more precisely, history, variety. Apparently, the researcher can detect and measure the effect of the aging process in his own frame of reference caused by the phenomenon of global time t(universe)=1/H: ds^2=c^2dт^2=g(00)c^2dt^2=(1-Ht*)c^2dt^2, where the Ht* parameter shows which part of the global the time "elapsed" in its own frame of reference, t* is the measurement time according to the clock of the resting observer, t is the duration of any physical process in its own frame of reference. That is, an observer can measure the increase in the duration of processes in the laboratory frame of reference: dт=[√ g(00)]dt=[√(1-Ht*)]dt~(1-Ht*)dt