Eight Supplements That *Actually* Work Dr Brad Stanfield

Eight Supplements That *Actually* Work Dr Brad Stanfield Transcript 0:00 eight supplements that actually improve 0:02 our health starting with creatine the 0:04 international Society of Sports 0:06 Nutrition concluded that creatine 0:08 monohydrate is the most effective 0:09 nutritional supplement currently 0:11 available to athletes in terms of 0:13 increasing high intensity Exercise 0:14 capacity and lean body mass during 0:17 training now it's important to note that 0:19 it primarily helps with short bursts of 0:22 high intensity exercise as demonstrated 0:24 by this meta-analysis concluding that 0:26 creatine supplementation is effective in 0:28 lower limb strength performance for 0:30 exercise with the duration of less than 0:32 three minutes in contrast creatine 0:35 doesn't seem to improve endurance 0:36 performance however it does improve 0:38 Muscle Recovery from training but it's 0:41 not just muscle performance and Recovery 0:43 that creatine seems to be useful for 0:44 there was a 2022 meta-analysis that 0:47 looked at cognitive performance and that 0:49 study concluded that creatine 0:51 supplementation enhanced measures of 0:53 memory performance in healthy 0:54 individuals especially older adults that 0:57 study did have its problems however 0:59 where the end individual studies that 1:01 their meta-analysis combined they showed 1:03 varying results and six of the 10 1:05 included studies had a high risk of bias 1:08 so we can't fully rely on that study 1:10 however the initial results are 1:12 promising when it comes to creatine 1:14 safety over a five-year period the 1:16 results have consistently shown that 1:18 creatine supplementation poses no 1:20 adverse health risks in particular the 1:22 literature does not support any link 1:24 between creatine supplements and kidney 1:26 dysfunction there's also no evidence 1:28 that creatine affects a hormone called 1:31 DHT and there's no evidence that 1:33 creatine causes baldness it does not 1:35 cause gout attacks it decreases uric 1:38 acid and the current clinical research 1:40 does not validate the notion that 1:42 creatine supplements causes dehydration 1:44 or muscle cramping the only consistent 1:46 side effect that's been noted is weight 1:48 gain but this is a good thing we're 1:50 increasing our lean muscle mass as in 1:52 our muscle stores personally I Take 5 1:55 grams of creatine every day including on 1:57 the days that I don't exercise and 1:59 sticking with the theme of exercise 2:01 performance let's have a look at TMG or 2:04 trimethylglycine TMG is thought to 2:06 improve muscle performance by delaying 2:08 fatigue in high intensity activities it 2:11 may also enhance muscle building we've 2:13 got great evidence from a 2017 2:15 meta-analysis showing that when you 2:17 combine exercise with TMG we see further 2:20 benefits compared to just exercise alone 2:22 and that's the key point when people are 2:25 given TMG and they don't exercise no 2:27 benefit is seen But when you pair TMG 2:30 with exercise you see further benefits 2:32 compared to just exercise alone for 2:34 example a 2021 double-blind randomized 2:37 controlled trial showed that 14 weeks of 2:40 TMG supplements improved one rep max VO2 2:43 max and repeated Sprint ability 2:45 performance compared to Placebo but it's 2:48 not just muscle performance for why I 2:50 take TMG a 20 20 meta-analysis looking 2:53 at the potential risk factors for 2:54 Alzheimer's disease or dementia 2:56 concluded that high blood levels of 2:58 homocysteine is factor and TMG lowers 3:02 homocysteine so what's possible not 3:04 proven but possible that TMG supplements 3:07 May reduce the chance of developing 3:08 dementia I take at least 500 milligrams 3:11 of TMG every day and we may see further 3:14 protective effects against Dementia by 3:17 adding in Omega-3 supplements a massive 3:19 study called the vital trial which was a 3:21 placebo-controlled study showed that the 3:23 group who took Omega-3 supplements had 3:26 an unexpectedly High 28 reduction in the 3:29 risk of heart attacks and a Mayo Clinic 3:31 meta-analysis that combined all of the 3:33 relevant clinical studies together on 3:35 omega-3 concluded that Omega-3 3:37 supplements are associated with a 3:39 statistically significant reduction in 3:41 the risk of heart attacks with high 3:43 grade certainty I take one to two 3:45 capsules of Omega-3 every day this is 3:48 for heart health and possible protective 3:49 effects for the brain the next 3:51 supplement that actually makes a 3:53 difference is psyllium husk more and 3:55 more research is coming out about how 3:57 crucial our microbiome or the bacteria 3:59 that grow in our gut is for our health 4:01 and we can feed our microbiome with 4:04 fiber from a 2016 Cochrane review we can 4:07 see that higher fiber intakes reduce 4:09 cholesterol and LDL cholesterol I mix 5 4:12 to 10 grams of psyllium husk into my 4:14 morning smoothie every day next is 4:16 collagen peptides or hydrolyzed collagen 4:19 from a 20-20 meta-analysis that combined 4:22 10 separate randomized controlled trials 4:24 concluded that all of the included 4:26 studies reported benefits of hydrolyzed 4:29 collagen on skin Health parameters 4:30 including moisture elasticity wrinkle 4:33 number and dryness and crucially there 4:36 were no inconsistencies seen between the 4:38 different collagen studies since then 4:40 we've had further studies such as this 4:42 one in 2022 again showing that 4:44 hydrolyzed collagen reduced wrinkles 4:46 compared to Placebo it's about an eight 4:49 percent reduction collagen peptides are 4:51 short chains of amino acids and amino 4:53 acids make up proteins so one 4:55 interesting question is whether collagen 4:57 supplements offer any further benefit 4:59 compared to just supplementing with 5:01 protein to explore this idea we've got a 5:04 2020 randomized controlled trial looking 5:06 at burn patients half of these patients 5:09 were given 36 grams of collagen peptides 5:12 and the other half were given 35 grams 5:14 of protein at the end of the study the 5:16 wound healing rate was significantly 5:18 higher following supplementation with 5:20 hydrolyzed collagen compared to protein 5:22 based on that study it does appear that 5:24 there are further benefits from 5:25 supplementing with collagen peptides 5:27 compared to just protein alone so for 5:30 that reason I supplement with 10 to 15 5:32 grams of collagen peptides every day 5:35 keeping with the theme of improving skin 5:37 Health let's have a look at hyaluronic 5:39 acid hyaluronic acid is present in every 5:41 connective tissue and organ it's the 5:43 backbone that holds everything together 5:45 but as we age our levels of hyaluronic 5:48 acid decrease to the point where a 75 5:50 year old person only has one quarter of 5:53 the amount of hyaluronic acid in their 5:54 skin compared to a 19 year old person so 5:57 multiple randomized controlled trials 5:59 have have been done looking at giving 6:01 patients hyaluronic acid compared to 6:03 Placebo and overall we can see 6:05 significant benefits from supplementing 6:07 with hyaluronic acid for example let's 6:10 have a deeper look at this 2021 6:12 randomized control trial after only 28 6:14 days of supplementing with hyaluronic 6:16 acid compared to Placebo there were 6:18 significant improvements in skin Health 6:20 the skin was more hydrated by about 10 6:22 percent and wrinkles decreased by almost 6:25 20 percent importantly that 2021 study 6:28 had no conflicts of interest to declare 6:30 this was not sponsored by a supplement 6:33 company now one of the safety concerns 6:35 about hyaluronic acid that you may hear 6:37 online is whether hyaluronic acid 6:39 accelerates cancer growth to explore the 6:41 safety concern hyaluronic acid was given 6:44 to mice that already had cancer and 6:46 using various Imaging techniques they 6:48 could see that hyaluronic acid had no 6:50 effect on cancer growth the other 6:52 important point is whether the molecular 6:54 weight of the hyaluronic acid changes 6:56 its effect on the body but it does 6:58 appear that hyaluronic acid is 7:00 decomposed into low molecular weight by 7:02 the intestinal bacteria so at this stage 7:05 we don't know which molecular weight is 7:07 best for hyaluronic acid supplements but 7:09 personally I take 200 milligrams of 7:11 hyaluronic acid every day number six on 7:14 the list is multivitamins 31 of the US 7:17 population is at risk of at least one 7:19 vitamin deficiency a lot of people 7:21 struggle to reach the optimal daily 7:23 intake for all of the different 7:24 micronutrients every day particularly 7:26 for vitamin B3 vitamin D vitamin K2 zinc 7:31 and magnesium but it's important to note 7:33 that I'm not advocating for mega dosing 7:35 all I'm suggesting is a low-dose 7:37 multivitamin to help patients reach 7:39 their optimal daily intakes for all of 7:41 the micronutrients I couldn't find a 7:43 multivitamin and mineral that met the 7:45 requirements that I was looking for so I 7:47 designed one myself it's specifically 7:49 designed to help people reach their 7:51 recommended daily intakes of 7:52 micronutrients without mega dosing it 7:55 also includes TMG and hyaluronic acid 7:58 it's called micro vitamin and it's 8:00 manufactured in a USA facility that's 8:02 FDA approved demand for this product has 8:05 been much higher than I could have 8:06 possibly predicted so apologies if there 8:08 are times where the supplement sells out 8:10 and you have to wait link is in the 8:12 pinned comment the final supplement that 8:14 I would take and this is only from the 8:15 age of 45 is neck now this is a bit 8:18 complicated as we get older our levels 8:21 of oxidants they tend to increase and 8:23 this is in an attempt to maintain 8:25 survival until they betray their 8:27 original purpose we used to think that 8:29 all oxidants are bad but our 8:31 understanding has changed instead what 8:33 we want is a balance between oxidants 8:35 and antioxidants and one of the most 8:37 powerful antioxidants is called 8:39 glutathione but from the age of 45 our 8:42 glutathione levels tend to decrease 8:44 Glycine and neck are the building blocks 8:46 of glutathione and by supplementing with 8:49 those building blocks we can help to 8:51 restore our glutathione levels and 8:53 maintain that balance between oxidants 8:55 and antioxidants for example a recent 8:57 randomized controlled trial to study the 9:00 effect of supplementing older adults 9:01 with Glycine and neck versus placebo 9:03 found that there were significant 9:05 improvements in mitochondrial function 9:07 we're still very early on the research 9:09 Journey with the strategy and of 9:11 everything that we've discussed so far 9:13 Knack has got the least evidence when it 9:15 comes to glycine collagen supplements 9:17 already have a lot of glycine so 9:19 personally I don't see much added 9:21 benefit from supplementing with glycine 9:23 alone and just to reiterate I would only 9:25 start taking Knack from the age of 45. 9:28 now in this video we're focused on 9:30 supplements but supplements are in no 9:32 way a replacement for a great diet so 9:34 make sure to check out this next video 9:35 here on the latest diet research a 9:38 massive thank you to do not age.org for 9:40 their ten thousand dollar donation to my 9:42 rapamycin study they are a health 9:44 research organization and to benefit 9:45 from their ingredients as well as the 10 9:47 discount code check out the pinned 9:49 comment Save 284,378 views Jul 8, 2023 #Health #Supplements 💊 My full supplement stack: https://drstanfield.com/pages/my-supp... 💊 MicroVitamin (multivitamin & mineral): https://drstanfield.com/products/micr... 💊 Supplements I use from Amazon: https://amzn.to/44oEGZz ✨15% Discount Code: BRAD ✨ • ProHealth: https://www.prohealth.com/collections... ✨10% Discount Code: BRAD ✨ • DoNotAge.org: https://donotage.org/products/ • Renue By Science: https://renuebyscience.com/?rfsn=5206... ✔️ Roadmap - Look Young & Feel Strong: https://drstanfield.com/pages/roadmap ✔️ Twitter: / bradstanfieldmd ✔️ Patreon: / bradstanfieldmd Here are the links to the research papers referenced in the video: https://jissn.biomedcentral.com/artic... https://pubmed.ncbi.nlm.nih.gov/25946... https://ods.od.nih.gov/factsheets/Exe... https://academic.oup.com/nutritionrev... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://pubmed.ncbi.nlm.nih.gov/28426... https://pubmed.ncbi.nlm.nih.gov/28426... https://jissn.biomedcentral.com/artic... https://pubmed.ncbi.nlm.nih.gov/21744... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://alz-journals.onlinelibrary.wi... https://www.mayoclinicproceedings.org... https://www.cochrane.org/CD011472/VAS... https://pubmed.ncbi.nlm.nih.gov/32436... https://pubmed.ncbi.nlm.nih.gov/36516... https://pubmed.ncbi.nlm.nih.gov/31859... https://www.ncbi.nlm.nih.gov/pmc/arti... https://pubmed.ncbi.nlm.nih.gov/34933... https://pubmed.ncbi.nlm.nih.gov/24894... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.science.org/doi/10.1126/s... https://www.ncbi.nlm.nih.gov/pmc/arti... https://pubmed.ncbi.nlm.nih.gov/24791... https://pubmed.ncbi.nlm.nih.gov/12398... https://academic.oup.com/biomedgeront... If you like this video please smash the thumbs up button, it really helps with the Youtube algorithm :-) #Health #Supplements The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel. Transcript Follow along using the transcript. Show transcript Dr Brad Stanfield 238K subscribers Videos About Patreon Twitter Shop the Dr Brad Stanfield store MicroVitamin: A Low-Dose MultiVitamin & Mineral $49.00 Achieve your recommended daily intakes of vitamins & minerals without mega-dosing. Blended with Hyaluronic Acid for glowing skin, and TMG for exercise performance. With over 75% of Americans taking dietary supplements, multivitamins have become a staple in our daily routines. But have you ever stopped to question whether your multivitamin is truly giving your body what it needs? Introducing MicroVitamin: A Thoughtfully Crafted Low-Dose Multivitamin. Most multivitamins on the market today contain excessively high doses of vitamins and minerals, which may lead to potential side effects and wasted resources. MicroVitamin is different. We’ve carefully crafted our formula based on scientific research to help you reach the optimal recommended daily intakes of essential nutrients (both vitamins and minerals) while promoting a balanced diet and healthy lifestyle. A Balanced Diet Comes First: MicroVitamin is designed to complement a healthy diet, not replace it. We believe that obtaining nutrients from a variety of whole foods is crucial for optimal health. MicroVitamin aims to fill the gaps and support your nutritional needs when your diet falls short, ensuring you maintain a well-rounded and balanced approach to your health. The MicroVitamin Difference: ️ Embrace Moderation: MicroVitamin is meticulously designed to deliver the perfect balance of vitamins, minerals, Trimethylglycine (TMG), and hyaluronic acid. This careful formulation avoids overloading your body and eliminates the risks associated with excessive supplementation. ️ Achieve Glowing Skin: Our unique blend includes hyaluronic acid 200mg, a powerful ingredient known to promote skin health and hydration, giving you a radiant complexion from the inside out. ️ Enhanced Performance: MicroVitamin doesn't just provide improved cognition through balanced nutrition, it also includes 750mg of Trimethylglycine (TMG). This compound has been shown to boost strength, power, and endurance when coupled with exercise. Additionally, TMG serves as a methyl-donor and helps lower homocysteine levels, providing an added health advantage. ️ Trust in Quality: Our commitment to excellence means that MicroVitamin is made with only the highest quality ingredients, rigorously tested for purity and potency, so you can have complete confidence in the product you’re using, which means peace of mind for you and your loved ones. Quality Assurance We’ve partnered with a USA supplement manufacturer called ‘Makers Nutrition’ to produce MicroVitamin. Their facilities are GMP audited and FDA registered, so you can be assured that MicroVitamin is meticulously produced and thoroughly tested for quality. SHOP Dr Brad Stanfield 756 Comments rongmaw lin Add a comment... Pinned by Dr Brad Stanfield @DrBradStanfield 10 months ago MicroVitamin (multivitamin & mineral): https://drstanfield.com/products/microvitamin Join Patreon for early access to my videos, the '5-Years Younger' online course, & Discord chat: https://www.patreon.com/bradstanfieldmd My full supplement stack: https://drstanfield.com/my-supplements https://donotage.org/products/ | Use code BRAD for 10% off 29 Reply Dr Brad Stanfield · 12 replies @MrAntonioDP 10 months ago (edited) 1. Creatine 2. Tmg 3. Psyllium Husk 4. Collagen Peptides/Hydrolized Collagen 5. Hyaluronic Acid 6. Multivitamins 7. NAC 8. Omega 3 803 Reply 46 replies @jwcas318 10 months ago 0:06: Creatine is an effective supplement for improving exercise performance and muscle recovery, with potential cognitive benefits and no significant adverse health risks. 0:06: Creatine monohydrate is the most effective nutritional supplement for increasing high intensity exercise capacity and lean body mass. 0:49: Creatine supplementation enhances measures of memory performance, especially in older adults. 1:20: Creatine poses no adverse health risks, including no link to kidney dysfunction or baldness. 2:06: TMG may improve muscle performance and building when combined with exercise. 2:50: Supplementing with TMG, Omega-3, psyllium husk, and collagen peptides may have potential protective effects for heart and brain health. 2:50: High blood levels of homocysteine are a potential risk factor for Alzheimer's disease or dementia, and TMG supplements may lower homocysteine levels. 3:19: Omega-3 supplements may reduce the risk of heart attacks, as shown in the VITAL trial and Mayo Clinic meta-analysis. 3:57: Psyllium husk, a source of fiber, can help reduce cholesterol levels. 4:19: Collagen peptides have been shown to benefit skin health, including reducing wrinkles, and may have additional benefits compared to protein alone. 5:59: Supplementing with hyaluronic acid and a low-dose multivitamin can have significant benefits for skin health and overall micronutrient intake. 5:59: Hyaluronic acid supplementation improves skin hydration and reduces wrinkles. 6:39: Hyaluronic acid does not accelerate cancer growth. 7:11: A low-dose multivitamin helps reach optimal daily intake of micronutrients. 7:45: The speaker designed a specific multivitamin called Micro Vitamin to meet these requirements. 8:15: As we age, our levels of oxidants increase and glutathione levels decrease, but supplementing with glycine and NAC can help restore the balance between oxidants and antioxidants. 8:15: Oxidants increase and glutathione levels decrease as we age. 8:35: Glutathione is a powerful antioxidant that helps maintain the balance between oxidants and antioxidants. 8:42: Supplementing with glycine and NAC can help restore glutathione levels. 9:13: Knack has the least evidence among the discussed supplements. Recap by Tammy AI 585 Reply 24 replies @fooleos 10 months ago Appreciate the update on the supplements you personally take, excellent info! 7 Reply @funkykong9001 10 months ago Thank you for your recommendations and research! 6 Reply @kimdavis7812 10 months ago I’m 61 & on almost all of those mentioned…& I feel AMAZING!! 53 Reply 2 replies @user-jq2sy5kz6z 10 months ago excellent analysis, as always, Doc 1 Reply @ranradd 10 months ago Thanks! Good list for sure. Reply @VTVT1306 10 months ago Thanks for this list. Very interesting Reply @Barb6106 10 months ago So much great information. Thank you Reply @hymns4ever197 7 months ago Very good video. There are a few on the list that I shall have to try. 1 Reply @DavidMM255 10 months ago This is a wonderful video! I'll check your multivitamin to help supporting your research! Great job Dr Brad! 4 Reply @Disasterina 10 months ago Thanks Brad great video! You tend to do most of your videos on supplements and pharmaceuticals but would love to hear your take on Molecular Hydrogen and Methylene Blue. Cheers! 2 Reply @emergentform1188 9 months ago Brilliant, thanks doc! Reply @shantidanceyoga 9 months ago Excellent channel with research backed information. Reply @clarencehopkins7832 9 months ago Excellent stuff bro Reply @pistacchini 10 months ago AWESOME INFORMATION THANKS Reply @andreipastushuk362 2 months ago A proper chapters breakdown would surely make this video better! 2 Reply @LauraPazzaglia 10 months ago Yaay! I'm already taking 7 of the 8. Originally I thought it was only 6 but as I was ordering TMG I read that it aids digestion - I'm already taking digestive enzymes due to gall bladder removal- so I found out that my digestive enzymes already include Beatine HCL! So I only ordered the magnesium taurate which I will take at the same time as my Vitamin B -complex that I take due to MTHFR C677T gene. Thanks for this quick video. Ciao from Italy! L 2 Reply @WhereNerdyisCool 10 months ago Dr Brad, a few quick thoughts! Creatine - I did Monohydrate for several weeks and got a lot of facial bloating. Cut the dose level, made sure I was super hydrated, same thing. I switched to Creatine HCI and all the bloating went away. I can't find much research on monohydrate vs HCI but for me, it made it possible for me to take it. I noticed you didn't include NR? I am still taking a daily 300mg Niagen capsule and I feel like it is definitely helping. At age 53, I'm told I don't look [or act[ my age! I'm already doing everything on your list, plus 2g of L-citrulline and magnesium glycinate at bedtime. Reply @alextrujillo6225 10 months ago Thanks for sharing your work. Can you do a review of Red light therapy? 3 Reply @nextphase7481 10 months ago During your review of the benefits of TMG supplementation you include a study at one point (2:41) that attributes improvement to 1-RM, VO2max and repeated spring ability performance yet the title of the paper you post concern the effects of chronic Betaine supplementation. Wanted to bring this to your attention. Thanks. 2 Reply @arthurdolle5257 10 months ago I have read that NAC should be taken with an equal amount of vitamin c. In recent talks about in NAC I haven't seen a mention of that. Do you think that's valuable? 9 Reply @R3v3r4nD 9 months ago Hi Dr. Stanfield, I greatly appreciate your science-based approach and delivering hard facts to the audience! I would be curious to hear your opinion on Bryan Johnsons stack. Some of the supplements you have already covered (like metformin) but I am curious about other. Best regards and keep it up! 1 Reply @nicom4811 9 months ago Thanks for this information. Any thoughts on Thorne's Fiber Mend product instead of psyllium husk? It primarily contains Guar Gum (8g) and Rice Bran (2.5g). Reply @michaelavestro3422 10 months ago Doc, can you reference some of the studies that relate to creatine and gout/uric acid? I had been a religious CM user, but have recently discontinued it as result of gout "sensitivity" that runs in my family. I'd love to continue to safely use it because I saw many benefits from supplementation. 1 Reply @ronaldthistle1299 9 months ago Thank you Dr Brad, I am wondering when is the best time to take creatine and is it best with food. thanks again Reply @switzerland 10 months ago Would love to get your view on athletic greens. It's totally overhyped and advertised everywhere, yet it seems to work for me, at least as an expensive placebo. 3 Reply @orioles1971 9 months ago I take most of the supplements that Brad talks about on this video. I use a combination of glycine and NAC but I don’t take a multivitamin. I take other vitamins instead like a multi B vitamin and D3 combination with magnesium and K2 and most of my supplements comes from do not age. Yesterday I visited my primary doctor and went over my blood test results and he gave me a once over and said for a man of 64 I am in excellent health. A 90% whole food diet, supplements and walking 5 miles a day is what is working for me. I am recovering from shoulder replacement surgery and plan on getting back to lifting weights as soon as I finish PT. 68 Reply 7 replies @1947froggy 10 months ago I do all except TMG, will look at it, thanks, you are my MD. I have local one as backup, haha. 1 Reply @jeffgilligan2004 10 months ago Regarding the NR trial: The vitamin did not reverse damage caused by glaucoma, but did stop further damage. 1 Reply @cosmo1505 10 months ago Has Dr. Stanfield ever discussed HMB supplementation? Curious to know what his opinion is on this supplement. 1 Reply @mickmiah7605 10 months ago TY Brad. Reply @realgains1538 10 months ago Brad what do you think of the cheaper phosphatidylcholine to deliver methyl groups , which also seems to improve brain health? 2 Reply @RaverClan 10 months ago Have you ever heard about the multivitamine Double X from the brand Nutrilite? It is enriched with fytonutrients from botanicals. What do you think about the effectivity of this supplement? Reply @richardmalone3172 10 months ago I have chronic bronchitis. As I get older it has been getting worse. I learned about how NAC relieves bronchitis by loosening the phlegm and make it easier to get rid of instead of coughing endlessly and not getting relief. I take 2 grams per day and it has been great. I can feel that I am getting full satisfying breaths and the need to clear the tubes is no longer constant. Just two or three times per day and it clears easily. 15 Reply 1 reply @javadivawithdog 10 months ago On the fence about where I need to add glycine. On TMG and collagenñ already. Novos is arguing that choline is a better methyl donor and glycine alone is more effective. I feel TMG/NAC has been effective. 1 Reply @Shrubbist 9 months ago You mentioned that creatine lowers uric acid, but you also mentioned in another video that that might be bad (Alzheimer's/dementia may be linked with lower uric acid). Thoughts? Reply @paulwolf3302 10 months ago This list is almost exactly what I do. Except I also take NMN instead of B vitamins and Magnesium is missing from my stack. I take NAC, but do not take glycine because I am already taking TMG. Once TMG donates its methyl groups it seems like you should have plenty of glycine around and not need to supplement it. Also, my vitamin D has K2/MK7 with it, which may not be a longevity molecule but is supposedly good for maintaining bone health. 17 Reply 4 replies @sojournerhouse 4 months ago Fantastic video. I want to get your micro vitamin and some others. Do they contain gluten? What about COQ10? I read that age and static use deplete COQ10. What do you think?TY Reply @lukeotoole9554 10 months ago Very interesting video although we know dht is a factor in some hairloss? And creatine can raise dht levels causing hairloss for some 1 Reply @antonystringfellow5152 10 months ago The 2022 GlyNAC study used doses of 1.2 g each of NAC and Glycine, 2.4 g of each and 3.6 g of each. The results showed a significant increase in Glutathione only in those with high oxidative stress and only after pooling together the results from the 2.4 g and 3.6 g per day groups. This seems to suggest that no benefit is gained in those not suffering from high oxidative stress and even then, a minimum dose of 2.4 g per day of both Glycine and NAC (4.8 g) is required. Another study (Kumar) used a much higher dose still and found no benefit in taking NAC without a similarly large dose of Glycine. That study used a dose that for me would amount to 7 g of NAC and 15 g Glycine per day. Considering the above, I see no point in anyone taking 1 g of NAC per day, with or without Glycine. Btw... I ordered some NAC before reading the papers in full. Note to self: Don't buy anything based on an abstract or conclusion you've read - read the whole goddam paper first! lol! 4 Reply 1 reply @TotallyAmSam 9 months ago Hey Brad, came here because of Gil's recommendation. Very informative and entertaining video, I'd be interested to see studies exploring the effects of cessation of some of these supplements compared to placebo groups :) 5 Reply 1 reply @Spartan21blue 6 months ago Feeding back regarding NAC I had been taking nac together for 2 weeks . I stopped taking nac because of the weird side effects , especially that of feeling of unease and being constantly on alert. Never felt that before with any supplement . Don’t like it one bit. Best of health everyone. Reply @dfoo75au 8 months ago The only issue with creatine is it triggers my elderly mother's gout and certainly the kidneys (she has borderline poor kidney function). So, unfortunately I stopped giving her creatine for her mental improvement. The throbbing painful toe in the morning after a dose of creatine is not a subjective experience when you can see it and feel it. 7 Reply 1 reply @alrivers2297 10 months ago Good information, Dr. Have you ever looked into astragalus root or herb? Supposedly, there's been studies saying it increases longevity by helping telomeres grow. As well as other benefits. 7 Reply 2 replies @captainnoyaux 10 months ago Do you think we can take psyllium with microvitamins or it's better to take after ? Reply @williammarcus2085 10 months ago Dr. Brad... it would be nice if you also indicated the doseage you take and your body weight. That could be useful. I know we are all individual chemical factories, but we are similar, and the dosages you take are likely based on supplement facts and the resulting amount to take to begin our evaluation. 9 Reply 1 reply @trompetsopp709 8 months ago Brad, I had some completely unexpected, but highly positive effects taking a high dose vitamin b-complex recently. From my reading these vitamins are essential to mitochondrial function and neurological health. Yet they are seldom mentioned in longevity circles. Why? And why are they not in your supplement stack? 9 Reply 2 replies @bigheartedgal833 8 months ago Have you done a video about calcium? I know that calcium is a much more complex supplement than what a lot of people realize. I'd love it if you did a video on it. Reply @Lulu-kt6gr 9 months ago I have a couple questions: regarding collagen supplementation: 1)does the collagen actually stimulate the growth of new collagen, or does it just deposit collagen in the tissues? If it just deposits collagen in the tissues, does it also stimulate ELASTIN which is necessary to support the collagen, because IF it’s just depositing, then I wonder if it would cause more sagging than anything. 2) I have noticed, with some collagen, supplements, that it causes my hair to fall out around my hairline, which is uncommon for women. I don’t like that side effect, so I keep stopping the collagen, but I have found one that doesn’t do that. I am wondering if you have any thoughts about why this might be happening? I am thinking that the supplements that use cows treated with bovine growth hormone might cause a disruption in female hormones and cause higher testosterone, which would possibly affect hair growth…? I would love to find these answers because I have yet to find anyone who will answer my questions. Thank you. Reply @manuelojeda9144 10 months ago Occasionally take Alpha lipoic Acid capsules too. 2 Reply @silviadavella4856 9 months ago Hi Dr. Brad , How do you feel about Maca? Reply @LTPottenger 10 months ago Taurine also boosts NAD+ levels, and reduces NADH in the cell, unlike nmn and niacin. 6 Reply 4 replies @ahochbaum 10 months ago Hi Brad, many thanks for your great summaries and insights. Just one question - in your supplement list are omega-3s from both Amazon and DoNotAge. Any preference for one over the other? Other than the amounts of DHA/EPA (some differences), any difference in quality or other difference? Reply 2 replies @paulcohen6727 10 months ago When my sister was diagnosed with cancer, the doctor took her off of TMG. I think it was because it will increase methionine which is a cancer risk. Is there any truth to this? will TMG increase Cancer risk? 2 Reply @gpwil3847 10 months ago What a relief that I am getting all of these, I am doing something right! Reply @BBRodriquez22 10 months ago (edited) Thx, but would be nice if you could add how/when you should take the supplements. Is it ok to take everything at once? Before, with or after a meal? Before or after training? Is Collagen ok to take before sleep? (I got the feeling it makes me tired when taken in the morning or middle of the day). Should you take it all the time or make breakes and if how long? Thanks again for the great info! 11 Reply @masimons 10 months ago Thanks, prefer smoothie with flax seed and chia seeds over psyllium husk myself; in coconut milk. 4 Reply 2 replies @intuitmusicgroup 8 months ago $2.00 Thanks! Reply Dr Brad Stanfield · 1 reply @auslanderbuchsbaum5623 10 months ago Interesting list, but I'm not sure about collagen supplements: they're expensive and I don't really see benefits (and some urologists raise concerns about kidney stones). I'll just stick to a good skincare routine. 1 Reply @NathanielStickley 7 months ago Any suggestions on how to prepare collagen peptides for consumption? Everything I've tried is vomit-inducing, due to the terrible odor. I've tried two different brands of powder. Reply @scottPL77 10 months ago Thanks for summerizing suplements protocol again. I would like to share this info to my non-English speaking friends, but under settings of auto translations in CC I can't find Polish. Can you please set this auto translations options to also offer Polish language? Thanks. Reply @vincentcausey8498 10 months ago There is a recent paper(s) into Gly-NAC supplement dosing at 100mg per 1Kg (for humans) body weight. One involved mice models and the other elderly people. Both Glutathione increased and tbars reduced in the humans. The title of the mice study is "GlyNAC supplementation in mice increases length of life by correcting Glutathione deficiency, oxidative stress, mitochondrial dysfunction and abnormalities in mitophagy". Reply @judybrown7601 7 months ago Thank you. Reply @mcaron45 9 months ago Thanks for this list. I'm taking most of this currently. I do have a negative experience with creatine however that I would like to report. I took 5g of creatine daily for years. In my mid 60's my blood work showed a high level of creatinine. Also, I started swimming training, and I got painful cramps after 30-40 minutes of swimming. I did some research and found somewhere that said high creatinine levels can cause cramping. I decided to stop the creatine supplementation and see what happens. My creatinine levels went down to normal, and I no longer had cramps when swimming. Maybe this is because my kidneys are not the best anymore, but that's my experience so please check your creatinine levels if you are taking creatine. I will take creatine occasionally for workouts where i want to focus on building muscle. 2 Reply 3 replies @simplatory802 10 months ago Hey Brad, I've been following you since you had 10k subscribers. Could you research Methylene Blue and do a video on it for anti-aging? Looks like a good candidate to me. 1 Reply 1 reply @SilverFan21k 10 months ago Based video of was glad to see it when i woke up. Longevity is one of my favorite subjects. 2 Reply @Hankyuo 10 months ago How come you never mention glutamine supplementation? Shouldn't it be useful since it's one of the 3 glutathione precursors? Or is it very easy to get enough from the diet? 1 Reply @meedy92 10 months ago What’s the safe dosing range for each of these supplements outside of what you’re taking? I have a personal trainer that’s advising I supplement with creatine but suggests I take it both before & after my workout which would result in me consuming more than 5g 1 Reply 1 reply @brianr2941 9 months ago Can you comment on the effects of D ribose and also I was taking collagen peptides, but I was having difficulty with urination until I stopped, and I’m not sure of correlation have you ever heard of this? Reply @littlevoice_11 10 months ago Part 2... top foods/medication/supplements you avoid for longevity 2023? 5 Reply @wakjob961 10 months ago (edited) Is it true that antioxidants slow or impair hypertrophy? Maybe not best to take NAC after a workout? Would be cool if you could include timing and whether to take some of these with food or not. 1 Reply 1 reply @SwaghettiYoloneses 9 months ago Can't take creatine anymore. It gives me long-term headaches. I did use to take it a lot when younger, .though. Anything similar worth taking? Reply @kekoakaawa8879 10 months ago Man, I wish I could take collagen peptides. Every time I do I feel anxious and depressed. I read an article somewhere, that says collagen powder lowers tryptophan, which lowers the amount of serotonin in your body-which can cause sleep disturbances, anxiety and depression. I also read that glycine- which collagen powder has a lot of, is a serotonin inhibitor. Some people seem to be negatively affected mentally/ emotionally by collagen peptide powder- sadly, I am one of those people. Not to mention- collagen powder can also generate oxalates and increase histamine- both of which I am also sensitive to. So not only do I get depressed and anxious on it, but I also get allergies and acne breakouts- ironic as it is supposed to benefit skin beauty. As for hyaluronic acid- as far as I know hyaluronic acid is made through a process of fermentation or uses a fermented product-fermented products increase histamine in the body- and I am histamine sensitive. On hyaluronic acid supplements I experienced nasal allergies/ stuffy nose. I wrote this for anyone who may be experiencing these symptoms on these supplements but don’t know why. In an effort to benefit my skin and muscles instead of collagen peptide powder and hyaluronic acid supplements I have been focusing on increasing my quality protein intake- eggs, fish, beef, chicken- organic. As for hyaluronic acid- I have been focusing on produce like sweet potatoes. Hope this helps. 4 Reply 4 replies @m.bouanane4455 7 months ago Thx Brad for ur efforts. What about supplementing with B12 for older people 50+ yr? Reply @MissesWitch 10 months ago What I really love about you is how you always make updates about these sorts of things! As new studies and research is always coming out! Recommendations always change, Some things are removed and some things are added, So it's always nice to know! 31 Reply 5 replies @djr3485 10 months ago I recall you were also taking B3. Has your opinion changed on this? 1 Reply @lumeshisthebest 10 months ago Are you referring to men taking TMG and these other supplements or are they safe for women as well? Reply @AThagoras 9 months ago I wish your MicroVitamin supplement was available in Australia. I'm sure it would sell very well here. Reply @dartharpy9404 9 months ago Thanks Reply @mymrgreg1342 8 months ago @DrBradStanfield Can you please detail your smoothie ? I'm taking the supplements you recommend but the taste of collagen for exemple is really difficult. How do you "hide" this taste in your smoothie / breakfast ? 1 Reply @michaelfletcher1224 3 months ago Is creatine safe to take if you already have hypertension? I've read that it might be a problem. Reply @markmark2469 9 months ago Do you recommend taurine supplementation? Been hearing good things. 1 Reply 1 reply @bob-ss4wx 10 months ago You did a video on Glycine / NAC and improved many anti-aging markers. Why have you decided not to take this protocol? Reply @bestcomment3589 10 months ago is it true that you need to separately take k2 and d3? 3 Reply @justinapaleckyte717 10 months ago Very interesting thank you. I have questions about phsylium husks read somewhere it prevents nutrient absorption and binds vitamins so they don’t absorb by body. How to avoid this? Reply @LidiYaFilms 9 months ago What about taurine? So many videos about it. Waiting for your opinion! 1 Reply @birdsdoingbirdthings 4 months ago what do you think of the nutritional content of fruits and vegetables these days? Is it much harder to reach sufficient nutritional intake given the content of the fruits/vegetables is partially dependent on soil quality? Reply @JReuben111 10 months ago If you have a high protein diet, do you need to supplement with GlyNac ? Reply @jenniebaker7180 9 months ago Are NAC and glycine safe for 75 y/o female stage 3 kidney disease? 2 Reply @martinoduane 7 months ago Complimenti! Reply @clarkebros6003 7 months ago Must begin this comment by saying I really enjoy this channel and the excellent objective approach to assessing the current dietary research. Being a research professor in biochemistry, I very much appreciate the use of research material when discussing the recent findings and hope that Brad keeps up the great work. I also have a cautionary tale that might be of interest to some. I'm a 59-year male and been very unhappy with the weight I gained during the covid period. After much research into different diets, I started six weeks ago a hybrid carnivore/keto diet and have so far lost 11 kg, now being only 3 kg from my target weight. I've been really pleased with this outcome so far but have recently experienced some issues that were unexpected. In the beginning, I was on an almost exclusive carnivore diet eating only animal-based foods but varied them as much as possible (red/white meats, salmon, cheeses and eggs, with some macadamia nuts as my guilty pleasure). I also started with a supplement regime similar to that recommended by Brad in this video to ensure that I didn't miss any crucial vitamin/mineral being on the carnivore diet. I've been taking a multivitamin pill each day, along with an omega-3, a hyaluronic acid, and a vitamin K2 (M7) pill, plus some creatine and collagen peptide powder plus psyllium husk mixed into no-sugar coconut milk. More recently, I've begun adding some low carbohydrate vegetables into the diet, hoping to begin transitioning to a more healthy long-term eating routine, and again all has been going really well. However, a few days ago, I started to experience stomach cramps and nausea 30 min after taking all these supplements, which at first wasn't too serious but has become increasingly severe with each following day. Today this culminated into an agonizing six hours of severe cramps, nausea and cold sweats, which was absolutely horrible. I suspected the culprit was the psyllium husk, possibly gelling in my shrunken stomach, and indeed this seems to be the case. After further searching online, it appears that such symptoms and more can indeed occur after six weeks of daily psyllium husk intake, and it appears that this husk is not really recommended for long-term use. Given the severity of my own symptoms, I thought I should share my experience in case anyone else is thinking to taking this husk over an extended period. Of course, I realise this reaction is only my own experience and might not be similar for other people, but I would be very interested in Brad's opinion on this and whether some warning about possible side-effects on using psyllium husk for extended periods should be given. 12 Reply 4 replies @lv1985aa 10 months ago Any concern with choline bitartrate increasing TMAO with the Microvitamin? Reply @carmenross1077 2 months ago Hi Doc I found your channel through the Physionic podcast, can you please mention vitamins that are CKD FRIENDLY, thank you so much.ff Reply @leland12345 7 months ago I've never heard of waiting to take NAC. I started taking it when I got covid. Does he have studies that show it shuts down your natural glutathione production? I know regular glutathione supplements do. Reply @joemarabella2145 7 months ago Any vitamins or medicines to get rid of cysts and abcesses? Reply @Saphira776 10 months ago I would love to try the Microvitamin but i do live in New Zealand, doesn't ship to here if i order from your website? Reply @stryker2828 9 months ago Brad, there are gluthaione supplements (for example from Life Extension). Why not take these instead of NAC? Thank you for sharing your knowledge and helping us! 9 Reply 2 replies @ricorix3439 7 months ago Interesting you mentioning NAC there for only over 45s. I have a story about that, when one of the main papers about it came out (the one with the trial in older adults from 2021), I was like 36-37 years old and was impressed with all those metabolic markers really improving, so i decided that i had to take it. I worked out the same dosages as in the paper, per my bodyweight etc (they were huge doses btw), and started taking it. In one week or less I was full of bruises in several places in my body... I don't know why exactly, but found out in other papers that both NAC and Gly can be blood thinners (gly reduces platelet aggregation and NAC interferes with clotting too etc). So my theory is that, as someone that already ate plenty of protein (going to the gym etc) and being relatively young, my levels of Gly and NAC were already high, so I ended up having too much of it (also not sure there is a mistake in the paper because it's a lot what they used). After that I largely reduced the dose and bruises went away. I do not take NAC nowadays, but I take a small amount (500mg) of glycine with my collagen supplement (which already has glycine, and proline, like you said). Reply 2 replies @OlaLoaKahuna 8 months ago You should look into OLA LOA developed by the founder of Orthomolecular Medicine. Also keep in mind the RDA/RDI does NOT represent optimum levels. This is the minimum requirement to sustain life. The original term was MDR-minimum daily requirements. Reply @nward1234 9 months ago @drbradstanfield do collagen peptides and hyaluronic acid really make it through the digestive system to enhance skin and joints? 1 Reply @shar7508 8 months ago Dr. Stanfield, what one supplement would you recommend for osteoporosis? Reply 1 reply @beit140 10 months ago Can you do a video on supplements that improve brain function? I have found that creatine helps with chronic headaches (unexpectedly ) and I'm looking for other supplements that I can take Reply 2 replies @pamelamutsaerts1037 8 months ago I read the book "super Gut bacteria William Davis about supporting the microbiome he said NAC was detrimental to your lmucous lining. Would love some clarification Reply @DrRomaioi 4 days ago Thomas, and thoughts on the FDA stance on NMN and and recent claims that resveratrol is not effective according to the likes of Dr Brad Stanford? I just bought them then learnt what I just referred to. Reply @audreyjohnson2358 8 months ago TY 1 Reply @andreasstamatakis4983 9 months ago I wonder if taking Broccoli sprouts and subsequent Sulforaphane increase would improve Glutathione levels better than GLY/NAC combo? Reply @TrueNaturalBB 10 months ago Can creatine increase blood pressure? Reply @jamesbright369 10 months ago I would like to know if any of these eight can be taken without a meal? I would rather spread out my supplements a bit when fasting. Reply @zachd.873 10 months ago how does psyillium husk comepare to something like benefiber? Is it strictly superior? or is benefiber slightly better for heart health since its all soluble? Reply @FredHinge100 7 months ago The problem is finding a collagen powder that has been found to be safe according to third-party testing with regards to heavy metals such as lead, cadmium, mercury and arsenic. If any body finds such a product that has been found to be safe by 3rd party testing for heavy metals, please leave a reply and a link or name of the product if possible. I suspect others would want to know this sort of information as well. Thanks. 3 Reply 2 replies @darealrulezbreaker9493 10 months ago What is the reason you chose magnesium taurinate over other forms of magnesium in your multivitamin supplement? Reply 1 reply @tonynesta3577 10 months ago Any thing for the older 60yo man for the prostate? I started taking NAC more regularly especially after a Bad meal of processed meats and alcohol (although I rarely eat those).. I also have a single kidney and possibly non alcoholic fatty liver disease and I think NAC, N-acytlecystine, does help because I do feel better. Thanks! Reply 2 replies @MrJohnson57 10 months ago I take 5 grams of creatine daily and have been for a year. My recent bloodwork indicated my creatinine is on the high side and my eGFR on the low side. I did a search on creatine consumption and creatinine and eGFR and found that creatine can affect these levels, but that these effects can be dismissed. I never heard a YouTuber promoting or evaluating creatine say that it can affect these levels, if only innocuously. Reply 2 replies @aeonmancali 1 month ago Concerning hyaluronic acid, is high or low molecular weight best for the skin. Thank you in advance Reply @zombiechow9974 10 months ago your multivitamin actually impressed me for having bio available versions instead metabolically slow cheep crap. Reply @mariawahrolen449 10 months ago I have been using psyllium seed husk for 30 years and my ibd has not come back since my pregnancy. The brand I have been using calls it ispaghula, so I didn`t know it was the same thing that I have been giving my horses (though thats whole seeds) to prevent sand colic! Reply 1 reply @ChadSextoid1 9 months ago A few months ago i gave creatine monohydrate a try. Unfortunately all it seemed to do for me was loosen my stool and cause my teeth to become sensitive. I was only taking about 3 grams of powder daily in my smoothie. For a supplement with such a good track record I was surprised how bad my experience was. Reply 1 reply @ahochbaum 9 months ago Just went over the paper that is reference in supporting creatine for memory ("Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials"). Want to point out that the conclusion that creatine helps memory is very weak, at best. The heterogeneity of the results of the different papers is huge. P-values are large (the only exception is when looking only at the elderly population). All other subdivisions, and looking at the entire population - there is no statistically significant difference. The difference shown for the entire study population stems from only 1 of the studies (McMoriss 2007b). Would definitely not put my eggs in the creatine basket if memory/cognitive decline was my concern! Also, the supplementary material referenced does not exist (at least I could not reach it through the links in the pdf). As for the exercise benefits - these seem much more substantiated. 1 Reply @ahefner33 8 months ago One side effect I noticed that is told by most is it causes water retention. That's why people with any type of HF are told not to use it. Reply @mamam.d.8898 9 months ago You're literally the best Reply @siddiqui49 10 months ago Any vegan alternative for collagen? Reply @jenniebaker7180 9 months ago If you already have CKD is creatine damaging? Reply @timo4945 10 months ago 5-10g Psyllium Husk dry or wet? Reply @bigthey1827 10 months ago I’ve heard you recommend niacin in the past as well, is there some reason that it was excluded from this list? 2 Reply Dr Brad Stanfield · 2 replies @bristephens9642 1 month ago (edited) thank u I am on the NAC and omega 3 Reply @zbridgjpxupzm 10 months ago My GFR (Glomerular Filtration rate of Kidney) was reduced a lot since I started taking Creatine and other supplements. I'm going to stop all supplements for a while and see if I can figure out what is the cause. Reply 2 replies @adorableparakeets3608 9 months ago Where to buy NAC Dr. Brad. Thanks Reply @agingdoc 6 months ago Apparently it took learning how to make my own youtube channel @agingdoc to start paying attention that YouTube has a comments section. Without getting into the weeds too much, it's refreshing to work on some of the few supplements that have some reasonable evidence based behind them (besides avoiding frank deficiency). Far fewer than a consumer would think based on aggressive wild west claims for many of these I think the popularity of you content reflects in part the strong demand for better information, and the odd health information milieu greater here than most other aspects of health and wellness science communication. Good to see it receive increasing attention by science communicators. Reply @daveb1234 10 months ago Is there a way to consume collagen or HA via diet rather than supplements? Reply @callanzz 10 months ago We can't order your MicroVitamin in NZ, where you're based? I don't see NZ as a shipping option on your store. Reply @ogonwaneri5553 10 months ago Why did you choose to include stearic acid in your multivitamin? Reply @stargazerbird 10 months ago NAC makes me horribly constipated. Collagen makes me sleepy all day and gives me headaches. In my case supplements are seldom worth it. HA is ok so far, as is NR or NMN. Reply @CrisusAttucks 8 months ago creatine is converted to creatinine in your serum, so it may noe damage your kidneys but it will increase your creatinine on you labs and decrease your GFR due to the creatinine in the calculation. 1 Reply @user-EinsteinSarge 9 months ago Possible topic for a future video: I just read how older adults should avoid the long term use of “anticholinergic” medications which have been shown in some studies to affect memory. Two of the common ones I had been using as a nightly sleep aid are Benadryl and Nyquil type meds. From what I can tell melatonin is not an anticholinergic med, at least it wasn’t shown on the list. Sleep is such an important part of the overall equation, and for those of us over 50 sleep can be elusive causing us to reach for sleep aids that may be negatively impacting our memory. Have you heard anything about these studies that you could share with us in an upcoming video? 10 Reply @mwalecz 8 months ago can you supplement collagen peptides ( about 5-10g) with your normal 20g protein gym shake? is it not too much protein in total for a low-ish calorie intake diet? Reply @rentalinquiry133 9 months ago (edited) Another valuable video, and so many great ingredients in your new multivitamin supplement! Very impressed that it has the expensive folate (and not the synthetic folic acid found in so many multi-vitamins). Also pleased that it contains TMG and especially appreciate seeing the high dose of Hyaluronic Acid (HA), except that the label is actually listing it as Sodium Hyaluronate (SA), which according to this video below, SH may actually be drying, rather than hydrating, like true HA. Video title: Let's Get Intimate: Hyaluronic Acid - Dr. Shereen Idriss https://youtu.be/RnrMi-PbBWA Dr. Stanfield, are you able to comment or do a video on if you agree with the dermatologist's video on this or if that SA ingredient should be changed to Hyaluronic Acid to provide the intended benefits? 7 Reply @Phoenixpapagei 10 months ago (edited) I am a scientist too. From the initial studies I thought NAC was safe. In the doses given in the low and high ranges reported in some of the Aging research papers you have cited on this channel everything looks like rainbows. However, this is far from the full picture. NAC sequesters Zinc and Copper, up to dangerous levels. Moreover, NAC in some people (10% of the population) can lead to dangerous anaphylactoid reactions. I got an anaphylactoid reaction from NAC from just taking it 10 days !( I was checked before by a doctor and had no health concerns before this happened). Other people on the internet have self-reported brain fog, dizziness, and other problems derived from long-term intake of NAC. In other studies it has been found that NAC can promote inflamation in the HPA axis. It is true that ROS increases when we age, and NAC might have a theoretical benefit for some people. Regardless, we DO need to perform more research on what causes the side effects seen in all anaphylactoid reactions so we can prevent them. 2 Reply 3 replies @gordonwho 10 months ago Does glucomannan provide the benefits as psyllium husk? Reply @dattomaster 10 months ago Can DMG be used instead of TMG? Reply @donmulder8061 10 months ago I've been on 5 mg creatine daily for the past 4 months. I did a complete physical before and after a few months of taking it and had a few favorable changes but I did notice that my EGFR score went down to 82 from 94 previously whereas a downward trend is not good. However my BUN to creatinine ratio was NOT APPLICABLE which supposedly means that all is normal. My urea nitrogen was up to 21 but still in normal range. I saw on a kidney doc's youtube channel that elevated kidney numbers when taking protein and creatine are normal and to be expected and not a sign of any adverse effects. I hope this is true. 2 Reply 11 replies @chazzlycurrie333 9 months ago The problem with NAC is in some people it can create the feeling of dystopia. That was my experience. I wonder why? Reply @davidplyler8173 10 months ago (edited) My list: Creatine, taurine, collagen, NAC & IP6 (IP6 on an empty stomach). I eat a beef based carnivore diet. Reply @djlouder 10 months ago Can your multivitamin replace all the supplements in it? Reply @robertmcghee3646 10 months ago What about colostrum? I take Collagan and colostrum. Haven’t noticed a big difference with collagan but with colostrum i notice a big difference (skin/nails/hair/etc). Reply 3 replies @BR-hi6yt 10 months ago Good video but NAC chelates and can remove metals from the blood that we need - care! I take it now and again but would not take it every day. Reply @robertusga 8 months ago Hi doc, is hydrolyzed collagen ok to use with impaired kidney function (stage 2, 3a) beyond risk of kidney stones Reply 2 replies @JNWG79 10 months ago Dr. Stanfield - Can you tell us whether the hyaluronic acid contained in your multi-vitamin is high or low molecular weight please? Thank you! Thoroughly appreciate your videos. Many thanks for your hard work! 2 Reply 1 reply @didotbasmayor 9 months ago what glutathione supplement or brand should i take its not mentioned Reply @Tomorrowstroops 10 months ago As my mind is almost paralyzed due to schizophrenia and it's meds, what do you suppose I do, to increase my mental faculties Reply @DarthNoshitam 10 months ago Why are the doses for everything (except B12) so low in your vitamin? Reply @maxtowers8076 9 months ago Does kre alkalyn creatine work the same as creatine monohydrate? Reply @ethanoyamawang 1 month ago What about taurine? Thank you! Reply @TheYyam85ahaz 9 months ago The study you referenced regarding collagen, the protein they used was SOY. Reply @comradecatbug5289 8 months ago Alternatively, you could just have a healthy and balanced diet and get all the nutrients you need from your food. Especially vitamins and fiber. It's been shown that vitamin supplements aren't utilized by the body as effectively as vitamins from whole foods. 1 Reply @boblivionbob2921 10 months ago How do you pick your collagen supplement? Apparently there is collagen type 1, 2, 3, 5, & 10 or something. Reply 1 reply @datsuntoyy 9 months ago I take 1000 mg of NAC a day because I take a lot of Tylenol for pain. NAC is what they give you for Tylenol (paracetamol) overdose to protect the liver. Reply @sanesp1025 10 months ago (edited) For the last 2 years i was on and off 2g of creatine for a few times. Whenever i was on creatine my resting heart rate increased considerably to about 80, (without creatine anout 60) and my blood pressure went up to 140/90. Also the PVCs i get occasionally increased considerably in frequency. I tested several on and off cycles to see if creatine is responsible, and yes it seems to be. By the way I am old, and have usually a natural BP of around 125/75 10 Reply 6 replies @brookstorm9789 10 months ago I would love yo hear you opinion about methylene blue. Reply @nicolerose7639 7 months ago (edited) The multivitamin suggested is only available through the link? Reply @lofm6213 2 months ago From decades of personal experience: DMAE works awesome to improve concentration. Saw Palmetto extract works great to shrink the prostate. Reply @farhat5325 10 months ago Could you please point to the study that says it decreases uric acid ? Reply @zAbdullahKhan 10 months ago Everytime I take Creatine Monohydrate, I feel like on fire. It heats up my body like having a fever, but without raising temperature much (on thermometer). Reply @hotdogint 10 months ago Although there's has been interesting studies for collagen in 2023, can't say I'm 100% convinced. The video refers to a study that compared 36g of collagen to 35g of soy protein. Really soy protein. A plant based protein cannot be 1:1 compared to an animal-based protein. Moreover, ~35g of protein is very small (it notes it as a supplement so perhaps there was more protein from other sources as well). What would be a practical study is comparing a high protein diet using primary animal based protein. So 1g of protein per pound of LBM. Half of the protein coming from animal protein and the other from other sources typically found in carbs, and fats. Of that animal protein, one group does all of it from conventional sources of animal protein, and the other group does a 50:50 split of conventional meats and collagen. Typically health cautious individuals eat a high protein diet due to working out. The real question is whether collagen has any benefits in an environment of an already high protein diet that would have all the specific amino acids in abundance that require to build collagen. 1 Reply @ShortSprintAus 10 months ago Chlorella worth looking into? Reply @JGComments 8 months ago Nothing for NMN/and+? Or do you consider this a drug rather than a supplement? Reply @CJWass09 10 months ago Chicory root is best. Psyllium husk has heavy metals Reply @scottmiller2591 10 months ago I save these every year. Reply @snave59 10 months ago I have been taking all of these for months,because, that's when I started watching your videos. Reply @Cha0z19 5 months ago I'm 30 yo, does it make sense to use supplements? Or a good diet and exercise do the job? Reply @manuelojeda9144 10 months ago I ALSO TAKE hyaluronic ACID Reply @beit140 10 months ago Creatine upsets my stomach and I can't take I\m afraid. Any special brand of creatine that doesn't do that? Reply @timeflys3322 9 months ago Do you still take Niacin? Reply @maf8199 10 months ago Your micro vitamin costs $49 for one bottle! That’s crazy! But your videos are so excellent I may even consider paying that much if I can’t afford it, but why is it so expensive and couldn’t make it cheaper? 2 Reply @mbmurphy777 10 months ago I don’t think it’s a great idea to compare collagen peptides to soy protein. And we better do compared to something like way, protein or egg protein I would think. Reply @Torch_Vs 10 months ago Collagen study compared collagen vs SOY protein I wish they could compare it with whey or beef Reply @RapidFireAU 10 months ago I take all of these however after 3months of daily use I don’t believe Hydronic is effective at all, also I believe HMB should be on this list instead Reply @vincentcausey8498 10 months ago AKG seems to have disappeared from the list. Has it now been downgraded? Reply @peterzurich3330 8 months ago Creatine gives me gout attacks. Is there an alternative? Reply @GeorgeStar 10 months ago Maybe I'm the sole exception but Creatine absolutely causes leg muscle cramps if I take more than about 1/2 tsp. a day. Reply @jimdandy8996 10 months ago What sort of interaction does circulating ingested collagen have on coronary plaque? 1 Reply 1 reply @AppleOfThineEye 8 months ago Isn't agmatine sulfate superior to creatine? Reply @freakingfreak743 10 months ago Do you have any opinion on TruAge Biological Age + Pace of Aging?? Comment for Dr Brad Stanfield 1 Reply @ianmyers5784 9 months ago 1:35 please elaborate on how creatine does not cause gout attacks. Reply @johnprice8655 9 months ago Joe do I get the multi vitamin you talk about Reply @seanjamesmacleod241 10 months ago What about magnesium? Reply @kobrad2448 10 months ago I heard magnesium stearate is not good in the vitamin supplements!️ Reply @nativeamerican8928 7 months ago (edited) I disagree about creatine even when I was in my 20s. Whenever I took creatine, my kidneys would start to hurt I went to the doctor one time and, he told me to stop taking creatine it was damaging my kidneys. I stopped and pain whent away along with all other side-effects that come from kidney disfunction Reply @marc-gregory-knowles 10 months ago Niacin or other B3 compounds? Reply @daroncresstwell1070 10 months ago How tight does the TMG need to be timed relative to the exercise bout? Reply @Taty14002 10 months ago Dr I’m sorry and maybe it’s just me but TMG works for me with or without. I’ve lost weight and got a little stronger. I did buy the psyllium husk and it made my stomach hurt and I got the shits bad. Reply @peterzurich3330 8 months ago Orthotopic mouse models revealed that creatine promoted invasion and metastasis of pancreatic cancer, colorectal cancer, and breast cancer. Thus, creatine possesses considerably complicated roles in cancer progression. Reply @fromjavatohaskell909 8 months ago 5:12 what a strange study : 100 g of sugar + 45g gelatinpowder ( 36 hydrolyzed bovine collagen) vs 80 g of sugar + 84g soy flour (35g soy protein) - how it could support claims that peptide form of protein is preferencial? Reply @pramuanchutham7355 10 months ago You downplayed the side-effects of creatine, similar to muscle pain and myopathy caused by statins... Reply @kproytube 7 months ago While i recognize there is a lot of general truth to this at the end of the day all our bodies are different n we have different diffecencies and would benefit from different supplementation due to our different genetics n lifestyle habits. However there's plently of stuff that caries over from person to person more or less. Reply @thepatternforms859 10 months ago The most powerful supplement you can take is NMN 1 Reply @scarface548 9 months ago I get cramps and sleep poorly on creatinine. Never got used to it Reply @LatimerClark 9 months ago (edited) Caution should be noted with Psyllium Husk - my view is that 10g of psyllium as a mono-prebiotic is a strong risk for generating dysbiosis despite a short term improvement in constipation and metabolic markers. I'm a Naturopath helping people with gut health. Psyllium has some good roughage effects and can help prevent excessive cholesterol absorption, but as a prebiotic there are better options with lower risks. Psyllium will increase Bacteroidota phylum (10-25% of microbiome) predominantly, and within that it will strongly and preferentially increase Prevotella genus (if you have it), which is often problematic (and associated with autoimmune Disease) in Western Diets, over the more common and beneficial Bacteroides genus. What we are looking for is good and balanced levels of Short Chain Fatty Acids (SCFA), especially butyrate, but also propionate and acetate. Prevotella mainly produce acetate, which is generally used for cross-feeding but too much can cause high pH and loose stool. Bacteroides mainly produce propionate, which is OK, but too much will stimulate GABA shunt, reducing GABA levels in the intestines and increasing inflammatory levels of succinic acid. Butyric acid is a preferential energy source for colonic enterocytes and exerts substantial anti-inflammatory effects in the colon. Any left over is exported systemically. While there are some Bacteroidota that produce butyrate, the vast majority of butyrate producing genus are in the Firmicutes_A phylum (40-75% of microbiome). Among Firmicutes_A, the predominant butyrate producing families are Lachnospiraceae, Ruminococcaceae, Oscillospiraceae, Acutalibacteraceae, Eubacteriaceae and Rikenellaceae. The fibres that these families ferment and that have been shown to increase butyrate are inulin, FOS, other fructans, GOS, Resistant starch (RS), Glucomannan (Konjac), PHGG, Acacia, Larch, Pectin, Lactulose. The principal foods would be roots (chicory, , burdock), tubers (yacon, Jerusalem artichokes, jicama, yams, sweet potatoes, konjac), alliums (onions, leeks, garlic), asparagus and globe artichokes. Then grains (wheat, barley, rye and oats), fruit (plantain, apple, pears, berries). Primary GOS are legumes (lentils, chickpeas and white beans). If you were going to supplement, I would use a mix of PHGG, FOS, Glucomannan and RS (Best is Novelose - modified tapioca starch - 63% RS) at 5-15g/d. If you bloat and have abdominal pain within 90 mins of eating any of these foods, get yourself Lactulose Breath Tested for SIBO. Final word - "Healthy gluten-free diets", with Psyllium, maize (corn chips and tortilla) and quinoa can be disastrous for people with higher levels of Bacteroidota, especially if that includes Prevotella species. Reply @mauromendez195 10 months ago 1. Creatine 2. Tmg 3. Psyllium Husk 4. Collagen Peptides/Hydrolized Collagen 5. Hyaluronic Acid 6. Multivitamins 7. NAC 8. Omega 3 1 Reply @jamesbright369 10 months ago I would like to know if any of these eight can be taken without a meal? I would rather spread out my supplements a bit when fasting. Reply @RagdyAndy 10 months ago This was a better video form you, i liked this one Reply @mattepton5731 8 months ago (edited) I think Dr. Brad will produce quality products Reply @haidersyed6554 10 months ago Omega 3 supplementation may cause atrial fibrillation 1 Reply @theMightywooosh 10 months ago What about amino acids versus collagen peptides ? 1 Reply 2 replies @pi3ni0 10 months ago Completely unrelated, but what happened to you video about melatonin? Reply @ryanturner7879 10 months ago The benefits to these supplements are clearly documented in literature but I'd LOVE to see a video where you explain how these supplements have benefited you as an individual. Have you noticed a difference taking these supplements individually compared to beforehand? Would make for an interesting video. 2 Reply @gaild1058 4 months ago I have been taking supplements for a while now and have to be careful as they seem to affect my hormones I am on HRT Reply @chrisfranco6603 10 months ago (edited) Creatine gives me a headache for some reason. I’ve seen a direct correlation even at small doses. And I’ve tried several different recommended top expensive brands. What’s up with that!? Reply 5 replies @bunnyfluffyfluffs 10 months ago doesnt hyaluronic acid feed cancer? Reply @phillipgriffiths9624 7 months ago Megadosing the vit b1 and b3 1 Reply @rinkuhero 10 months ago your multivitamin looks interesting but it isn't vegan (it contains shellac, and likely its d3 source is not vegan as most of them come from the wool of sheep). do you have plans on making a vegan version of your multivitamin in the future? Reply @Apyc89 10 months ago @drbradstanfield - thanks for this. What is the reason you would only take NAC at 45 year old as opposed to earlier? Specifically, does it harm or have theoretically no benefit to the person? If neither, could one take NAC earlier but may not have the benefit be as evident as a 45 year old. Thank you and I understand any advice should go through my own physician. 4 Reply @TheHomeExpert5 10 months ago What about sulforaphane? 1 Reply @giovannidominoni 10 months ago but why to take omega 3 supplements when you can eat herring and salmon and get all the omega 3 you need just by eating healthy? 3 Reply 1 reply @stanthebamafan 8 months ago I’ve been taking vitamins and supplements for 10-15 years. But lately I’ve been reducing some of the vitamins because I realize that I already get a lot of what I need because I eat a very healthy diet with mostly red meat, fish, eggs, beef liver, fruits. The main supplements I endorse are the ones that are hard to get in sufficient amounts from food, like D3, magnesium, fish oil. 9 Reply 6 replies @josephjroy6593 10 months ago Vitamin D. Officially recommanded by the NHS in the UK between months of October to March. 4 Reply 2 replies @erinhymaadams8770 9 months ago What brand of oral HA do you suggest ? Reply @apostlevictoriaalston2560 9 months ago What I want to know is, what can you take and what exercise to do 3:47 when One is in their 60th?? So important!!! 1 Reply 2 replies @muhannaddiraneyya1866 5 months ago You didn't mention the controversy about the collagen absorption Reply @51249ca 8 months ago And here comes the Sales pitch Reply @i_accept_all_cookies 10 months ago Is there a link between reduced wrinkles and longevity? Reply 3 replies @KillaCommieFerMommie 10 months ago No DHEA and no Ubiquinol? Reply @user-cl7pm7zm3x 6 months ago What about lead cadmium and other heavy metals abundant found in psyllium husk?? Reply @Chris-vt6nl 10 months ago I agree with everything listed except the multivitamin because most multivitamin are synthetic very poorly bio available so the best way would be getting vitamins from nutritional food 5 Reply @furiousdoe7779 10 months ago Why do you let the multivitamine only be produced in USA and not also in Europe... There are enough qualified pill makers who can do that . The export from USA to Europe is expensive . Kind regards 1 Reply @bestcomment3589 10 months ago why did u put steric acid in product? 1 Reply @andreykarayvansky9549 7 months ago I'm not a doctor and it's hard for me to understand how (3:26) how "no reduction in CVD risk" is possible with "28% reduction in the risk of MI" Reply @ybwang7124 10 months ago Can say creatine definitely works I lift heavier when on it... as for no side effects... any drug has side effects, its just whether it is known Reply @schiller2222 10 months ago NAC increases the risk of lung cancer. Antioxidants may decrease oxidative damage in metastatic cancer cells, leading to their proliferation. Due to its antioxidant mechanism, NAC may also accelerate the progression of some cancer growth. The transcription factor BACH1, a master regulator of metastasis, is stabilized by NRF2 through induction of heme oxygenase. NRF2 activation promotes lung cancer metastasis by inhibiting degradation of BACH1. NAC stimulates NRF2 under some conditions in tumorigenesis and tumor progression. Dietary antioxidants caused BACH1 stabilization and increased metastasis in a lung tumor model. 2 Reply 4 replies @drmanhattan225 10 months ago How about apigenin? 1 Reply @phillipgriffiths9624 7 months ago Vitamin D and K2 should be included here! 1 Reply @johnbaker2478chinaballs 9 months ago With creatine what about Prostrate enlargement in some men? Reply @manuelojeda9144 10 months ago I take TMG POWDER AND NR BUT I ONLY WALK AROUND BECAUSE I RAISE MY OWN CHICKENS IN MY OWN BACKYARD. Reply @monicaluna1227 10 months ago And what about young adults? my son is 21 years old and he is starting to workout at the gym. Do you recommend the same dose for them? Thank you for all your recommendations and research. 2 Reply @gregexplorer8901 7 months ago what about microdosing lithium orotate for brain health? Reply @aseemshrestha3354 10 months ago No NMN or NR andnOmega 3 ?? Reply @DivineAtheistWannabe 2 months ago 5:14 ummmmm is it just me, or does that study say "soy protein" was used to compare with collagen peptides. Isn't soy protein incomplete. And aren't they severely lacking in the amino acids required to synthesize collagen, or am I missing something here. Reply @ytsux9259 10 months ago Every day, I take all the supplements available on the market and am strong as an ox and will live to 200 years. 2 Reply @manuelojeda9144 10 months ago With whole food Vitamin C. Reply @sufyaancarim9178 9 months ago Glutathione beneficial or waste of money? Reply @ClassicalLiberalWarrior 10 months ago (edited) $2.00 I've been studying longevity science as an amateur since 2017 or so, and I think Dr. Stanfield is the best researcher out there (and ahead of Prof. David Sinclair). This video and many others are quite insightful and helpful, in my opinion. My strongest disagreement with this video analysis, and its eight chemical recommendations, is I think it omits oleic acid, which seems to be the key to the Mediterranean Diet. I recommend about 10-20 black or green olives a day. 3 Reply @steveadler4090 9 months ago When I took NAC I lost a lot of hair so I stopped . 1 Reply @melcompleto 2 months ago Certainly! Here are some supplements for which there is strong evidence supporting their benefits: Omega-3 Fatty Acids (Fish Oil): Evidence suggests that omega-3 fatty acids, particularly EPA and DHA found in fish oil, have numerous health benefits, including reducing the risk of heart disease, lowering triglyceride levels, and potentially reducing inflammation. Vitamin D: Vitamin D plays a crucial role in bone health, immune function, and may also have a role in reducing the risk of certain cancers, such as colorectal cancer, as well as improving muscle strength and reducing the risk of falls in older adults. Calcium: Calcium is essential for bone health and may help prevent osteoporosis and reduce the risk of fractures, especially in postmenopausal women and older adults. Vitamin B12: Vitamin B12 is important for nerve function, red blood cell formation, and DNA synthesis. Deficiency can lead to anemia and neurological problems, particularly in older adults and vegetarians/vegans. Probiotics: Probiotics are beneficial bacteria that promote a healthy gut microbiome. They may help improve digestive health, alleviate symptoms of irritable bowel syndrome (IBS), and strengthen the immune system. Magnesium: Magnesium is involved in hundreds of biochemical reactions in the body and is essential for nerve and muscle function, blood glucose control, and bone health. Folate/Folic Acid: Folate is important for DNA synthesis and cell division. Adequate intake before and during pregnancy can reduce the risk of neural tube defects in infants. Iron: Iron is essential for transporting oxygen in the blood and supporting energy production. Iron deficiency can lead to anemia, fatigue, and impaired cognitive function. Vitamin C: Vitamin C is a powerful antioxidant that supports immune function, collagen synthesis, and wound healing. It may also reduce the duration and severity of colds. Zinc: Zinc is important for immune function, wound healing, and DNA synthesis. It may help reduce the duration and severity of colds and support overall immune health. Remember, while these supplements have strong evidence of benefit for certain populations or conditions, it's important to use them appropriately and consult with a healthcare professional or a registered dietitian to determine if they are right for you, especially if you have any underlying health conditions or are taking medications. Additionally, obtaining nutrients from whole foods whenever possible is generally preferred over supplements - https://www.livegood.com/LIVEGOOD_SAUDIARABIA Reply @jgesselberty 8 months ago Used creatine regularly and had three bouts of kidney stones. Stopped use and have had no stone for 15 years. Reply @user-wn9bf8by9w 9 months ago why would they compare collagen supplements with soy flour which is bad vegetable protein ? Reply @WiecznieNieNasycony 9 months ago For omega 3 you need like 10 grams a day min to feel it l take even 20 grams a day) Reply @bernadettebondoch951 8 months ago What about if you have Type 1 Diabetes? Reply @beccacertifiedpersonaltrai3636 9 months ago Creatine mono messes up my stomach. Creatine HCL does not. 1 Reply @____2080_____ 10 months ago I’ve taken all of these for the last 20 years. 1 Reply 1 reply @maressacox 10 months ago The problem is most omega 3 is rancid. Very inflammatory Reply @stevethea5250 7 months ago 1:20 perhaps you could directly dispel where these claim are from.. would be thorough as well Reply @zakkiuddin5551 10 months ago What about NMN sir 1 Reply @spekulatius1337 10 months ago Isn't TMG just glycine like what ~20% of the collagen powder consist of anyway? Reply 1 reply @paul715 10 months ago Doctor, are you going to make response videos to Wellness Messiah? He's been criticizing some of your videos. 4 Reply @davidlakes5087 8 months ago Why does that creatine study say 0.3g to 0.8g / kg / day? That dosage is extraordinarily high. Reply @sabymondal 10 months ago I am confused now. What about NMN? Reply @clauzone03 10 months ago MicroVitamin recipe can be improved by taking out toxic Magnesium Stearate and using gel capsules instead - I don't buy anything that contains Magnesium Stearate. Reply @viveviveka2651 8 months ago Effect size is important to know. Two percent or less is not important enough to many people. 30 percent or more is huge. I would not bother with supplements that give virtually no results. But I would buy immediately if the effect size were substantial enough. Also, to what percentage of people do the benefits apply? A study can show benefits if even 10% of people benefits, but 90% of people might just be wasting their money. And are there differences between groups, such that certain groups are the main beneficiaries, or the ones who get nothing at all for their time, trouble, hope and money? Reply @tomnelson7898 6 months ago Interesting channel. I like your content BUT please start using time stamps. I’m more likely to visit your other videos. Time stamps help people (like me) figure out (1) if we want to watch and (2) what to skip / watch because maybe we already might know some of the info in the video. An organized Chanel of content (time stamps) is a successful channel. 1 Reply @CJWass09 10 months ago Creatine also increases prolactin Reply @forexcharts281 9 months ago (edited) People always discredit people. This is why people are so confused what to eat! 1 Reply @jamescokl3 3 months ago Is it safe to take 7 supplements on top of a multivitamin daily. Reply @jerryjoyce5781 9 months ago I thought ascorbic acid was a chemical form of vitamin c mostly from china, is this correct? Reply @Aetherius88 10 months ago And Rapamycin? Or jury still out on that one? Reply @danieljrgensen133 10 months ago I found most interesting, that Dr. Brad now has finally found out, that hyaluronic acid is broken down to low molecular weight molecules, in the intestines. So buying HMW version for a premium price(in comparison), is wasted money! Like I've said, ever since D.N.A launced their hyaluronic acid supplement! Reply @AlanAC22 10 months ago (edited) high quality olive oil, once you take that you can start to think about supplements 1 Reply @MikeAffholder 10 months ago That's weird siim land says nac and glycine help him from aging. Reply @pacpern9988 10 months ago No Berberine or Taurine? These are very effective 1 Reply 1 reply @VietYork 4 months ago recap from Mollyverse 00:00 Creatine monohydrate is highly effective for short bursts of high-intensity exercise and muscle recovery, but not for endurance. 00:41 Creatine may enhance memory in older adults, though studies show mixed results and potential bias. 01:10 Creatine is generally safe over five years, with no links to kidney dysfunction, hormone disruption, or dehydration. 02:04 TMG (Trimethylglycine) enhances muscle performance when combined with exercise. 02:58 TMG may lower homocysteine levels, potentially reducing dementia risk. 03:26 Omega-3 supplements significantly reduce heart attack risk and are beneficial for heart health. 04:09 Psyllium husk fiber improves gut microbiome health and reduces cholesterol. 04:24 Hydrolyzed collagen has proven benefits for skin health, improving moisture, elasticity, and reducing wrinkles. 05:45 Hyaluronic acid supplementation improves skin hydration and reduces wrinkles, with no evidence of accelerating cancer growth. 07:21 Multivitamins help in reaching optimal daily micronutrient intakes and may include TMG and hyaluronic acid. 08:15 From age 45, N-acetylcysteine (NAC) may help maintain balance between oxidants and antioxidants, supporting mitochondrial function. Reply @beakhammer2638 9 months ago As a GP if I saw an unusually raised creatinine level in a young man I often found that he was on Creatine for body building. Having spent 8 years in Dialysis medicine I was particularly sensitive to changes in Urea and Creatinine levels. If I can pass on anything about end stage renal failure: Protein balance really matters. Too much protein is a renal toxin, but at the same time too little crumbles the rest of your systems. Keep protein intake on the low side of this balance for elderly or failing kidneys. Many people live with quite severe deficiencies in Renal function and don't know about it, and it is not brought to their attention by their doctors for fear of worrying them. These people, the diabetics, the IgA nephropathies, the youth glomerulonephriditdes, the one kidney people need to protect their renal function like gold as they age. Is pumping Iron and taking quantities of protein and creatine good for kidneys? Thanks from Ireland. 5 Reply @shaheryarnaqvi8 9 months ago What about garlic supplements 1 Reply @ivydune4185 9 months ago I take glucosamine as I read that it produces hyaluronic acid. Reply @yamishogun6501 1 month ago Stanfie says he takes 1 or 2 capsules of Omega-3 but doesn't say how many milligrams. 1 Reply @joemoya9743 10 months ago To bad you added Betaine Anhydrous to your multi-vitamin. Some people with high cholesterol might see an increase in LDL. Reply @MultiCII 8 months ago Omega 3 over 10 years increases the risk of new atrial fibrillation. This means increased risk for new stroke. He failed to mention these recent studies. Reply @livingsmart 10 months ago What we miss is a good Carnosine clinical trial looking at glycation. 7 Reply 5 replies @SusanBame 10 months ago You left D3/K2 off the list. I would think those are the most important supplements to be taking. 2 Reply 1 reply @MyHasnainali 10 months ago Everything looks fine about MicroVitamin but Thiamin HCI and Pyridoxine HCI is where you lost me, It should've used Benfothiamin and Pyridoxine 5' Phosphate instead! Reply @oldmanjoe6808 8 months ago There's only one part I missed... The part right after you said "Hello." Reply @drainmonkeys385 7 months ago I’m curious why they develop one peptide. Or like a package of injectable peptides that cover every issue in the human body.. so a fat person who wants to fix their health problems can get all the benefits of Sermorelin. Tesamorelin. Bpc157 etc…. A long chain of aminos that flip the switch on all the various organs that give us longevity Reply @3Pillers 10 months ago Reply @saralakushwaha1180 10 months ago Reply @Divyne4Donofrio 8 months ago Your videos are absolutely brilliant and helpful. I've been taking vegan phytoceramides for the past year. I recently can across a study done the University of Utah that indicated some dangers associated with the use of oral cerimides. However, I've come across much more information that indicates the benefits. I'd be very interested in hearing what you have to say about them Reply @nedmatic1329 10 months ago K2 AND D3 ? Reply @darrenwalshe8513 7 months ago No vitamin d3! If I only had to take 1 supp it's d3 for defo Reply @yearight1205 10 months ago even though I do lift weights, I actually don't take the creatine for fitness. I take it because I noticed it helps me with my severe depression. Mind you I personally believe depression is simply dissatisfaction with one's circumstances as opposed to something medical, but it helps make it more bearable. 1 Reply 1 reply @RobertFairweatherMusic 10 months ago Doctors receive almost no training on nutrition. What makes you so knowledgeable on something you are typically not trained in? Self study? 2 Reply 1 reply @basbeenakker 7 months ago I like Creatine but it makes my skin red in my face. Reply @monishag8974 9 months ago Hyaluronic acid might be risky for folks with pancreatic cancer. Reply @Quixote1818 7 months ago I take a multi vitamin just twice a week. Just to fill any holes. Reply @sylvaind 10 months ago They used soy protein, sadly, instead of whey 1 Reply @phonixsolomon6275 10 months ago And curcumin? Reply @2710a 7 months ago Tmg can increase LDL which is a proven risk factor of heart disease Reply @kathieod10 8 months ago You didnt say how much NAC? Reply @philipsimmonds1103 10 months ago Chlorella Reply @starfox300 10 months ago NMN is actually better than creatine Reply @iamjuandemarcus 7 months ago Creatine can cause baldness for sure Reply @hansnielsen6280 10 months ago Every time Brad makes recommendations, all the comments are like: “What about [XYZ] supplements? Reply @jamesedmonds926 9 months ago This commercial paid for by the vitamin industry Reply @specialagentzeus 8 months ago Just eat plenty of eggs, avocados, and a sprinkle of NMN and you will look and feel amazing. Reply @xtian384 10 months ago until somebody says they don't Reply @mrokar108 10 months ago you are rl doctor? is somewhere your degree? Reply @hermanparisius2828 10 months ago So basically this is a commercial for your product 1 Reply @mikeh2460 9 months ago (edited) You arent advocating for megadosing but your b12 dosage is 50,000%.... makes sense. Reply @educationcentral_ 3 weeks ago You know I was wondering why he was so against David Sinclair’s research and then I found out he has affiliate links Reply @orion9k 10 months ago 2caps of fish oil wont do anything.. You need at least 1000mg DHA. Reply @garyarendash8571 10 months ago I am a Ph.D. in Neuroscience and Physiology who has been doing Alzheimer's and anti-aging research for many years. I applaud your videos that provide the real scientific evidence regarding claims of this or that in the aging process. Unfortunately, none of the supplements currently on the market will protect or treat diseases of aging, including Alzheimer's Disease. I wish it were as simple as taking a pill or group of pills daily to protect against or lessen severity of age-related diseases -- but it isn't. My colleagues and I have developed a brain interfacing technology that does indeed address the multiple causes of aging and that holds great promise for extending human healthy longevity (Int. J. Mol. Sci. 2023, 24, 9652.). We have been in stealth mode for three years, but will be coming out with our bioengineered technology at the "Ending Age-Related Diseases" conference in NYC on August 10-11th. Our technology, interfacing with the brain similar to Neurolink, rebalances the human immune system both systemically and in the brain, eliminates toxic oligomers in the brain, and increases energy production (mitochondrial enhancement) in the brain. Our bioenginerred technology stops and reverses Alzheimer's Disease, albeit in a small study. It is time for the real players in human health and longevity to come forward, and not the false claims of Big Pharma. Thanks again for your exquisite work in enlightening the public through your presentation of real scientific studies and through negating the hype of self-proclaimed experts who come forward every few weeks with new U-tube videos extolling false claims. 28 Reply 5 replies @samuelwilson1537 10 months ago I curious if Creatine triggers Mtor Reply @Philson 10 months ago Isn't Hyaluronic Acid supposed to be applied to the skin? 1 Reply @aagribeiro1975 10 months ago “I couldn’t find a micro vitamin that met my requirements, so I made my own” - Dr. Oz, is that you? 1 Reply 2 replies @Guishan_Lingyou 8 months ago Regarding the MicroVitamin product that you developed, I was surprised to see that it contains 50 times the daily value of B12. Curious what the reason for that is, especially considering the way the product is being described. 1 Reply 1 reply @BadwulfGrey-ef2zj 10 months ago PHGG > Psyliium Husk. Reply @micron1983 9 months ago You forgot the very beneficial Taurine! Reply @tiagomoraes1510 10 months ago I see you use cochrane a lot as your source. Just want to remind that in 2018 they fired his board director (And 4 members got out because of that) and there was allegations that they are being influenced by the farmaceutical industry. 1 Reply 2 replies @amirghasemi8133 5 months ago they say multivitamins dont really work Reply @bonniewilson9709 9 months ago No I spent my life getting it out of my system 1 Reply @MrHyperpolyglot 10 months ago Reply @nicoc7024 9 months ago Any harm in taking NAC before the age of 45? Reply 2 replies @Robert-dx4wv 10 months ago Why is your multivitamin supplement $49?? It's a little expensive, I figured the highest amount anyone would pay for a simple multivitamin is $35. 2 Reply @sojournerhouse 4 months ago Correction: STATIN use Reply @CrisusAttucks 8 months ago The very first item on anyone's list should be exercise, Second one should be low carb focused diet. people have come to believe all they need is a pill or the right supplement, both my parents were like this....never exercised for one minute of their entire life, both died in their mid 70s. My mom took every supplement under the sun, my dad smoke like a chimney and drank like a fish, but both died at 75, one from heart attack in his sleep, and the other from a massive stock while she was in the hospital. exercise is the only proven therapy Reply @HemantPandey123 7 months ago Future is multi enzymes in living liquid. Reply @qilinwang5889 7 months ago First time here and this is he second video I have watched from this guy. Conclusion: I had doubts over him in the last video and now I just plainly don't trust him. 1 Reply @dodgerswschamp5166 9 months ago Be careful with collagen peptides!!! Collagen peptides are incomplete protein, missing tryptophan, an amino acid. So when you take 15 grams or more, it will draw tryptophan from your brain and your blood, leaving you extremely fatigued in some cases. Eat enough protein with tryptophan like chicken, fish, peanuts, etc if you're going to take collagen peptides. I was out for a walk and after ten minutes, I literally passed out on a bench and slept for ten minutes before I could walk again. 2 Reply 1 reply @joenisnapje712 7 months ago HA should not be used by anyone who had or has cancer️ Reply @drmartinjolicoeurdcchiropr5659 10 months ago Nothing about vitamin D??? Reply @bernardedwards8461 8 months ago Dr Stanfield wont need any food, he has three meals of supplements every day! It must cost him a fortune. Reply @elephantintheroom5678 10 months ago I think I'll stick to fruit, vegetables and greens, thank-you very much. 5 Reply @jamesritz7254 8 months ago Go buy three donuts and a coffee and FORGETABOUTIT 1 Reply 1 reply @darkhorseman8263 10 months ago I've started putting creatine on my morning breakfast, cause I'm a weirdo. 1 Reply @angelicannihilator 10 months ago The thumbnail of a bunch of pills on a spoon makes me nauseous for some reason. Nobody does that, lmao 2 Reply @ChrisWoodsViolin 10 months ago I want to live forever 1 Reply 1 reply @FantasticExplorers 10 months ago It's so funny/ironic/sad how people have ignored fiber for the last 20 years... When I was a kid everyone thought it was the most important thing to eat. And because of the foods that fiber are in... They were right!!! Reply @HUgdJHf64 9 months ago so the kidneys has to filter them? why? Reply @Erictraiven 10 months ago What about nmn? Reply 3 replies @BreakingSWTM 6 months ago Creatine hurt my kidneys. Reply @guravi4295 8 months ago Done! Age 25 here I come again! Reply @JennifertxCarnivore 8 months ago Carnivore lifestyle doesn’t need supplements! Reply @manuelojeda9144 10 months ago I take COLLAGEN PEPTIDES DAILY. Reply @danielmedina1136 7 months ago This guy's company ripped me off Reply @tomislavzivkovic3978 6 months ago In another video you said that multivitamins are a waste of money Reply @shyrocket4889 5 months ago About the microvitamin, just snap a multi in half, job done Reply @johnprice8655 9 months ago Sorry I do I obtain the multi- vitamin you discuss Reply @JackSquat54 8 months ago Dr. Stanfield, you seem to be Dr. Pillpusherforprofit to me. Reply @juntjoonunya9216 10 months ago Why not just eat more straight red meat and fruit veggies for all these supplements 1 Reply @VishalRaoOnYouTube 10 months ago 5:16 Soy protein has a rather poor amino acid profile for humans. They should have compared 36g collagen supplementation to supplementing 36 grams of essential amino acids (8g Leucine, 4g Isoleucine, 4g Valine, 2g Methionine, 4g Lysine, 2 g Histidine, 4g Phenylalanine, 4g of Tryptophan, 4g of Threonine). I'd put money on the EAA's performing better. Reply @whiteninja9481 10 months ago Thus says a robot. All humans run to the store now and purchase. Reply @bluemysticspirit1460 9 months ago Dr. Stanfield: this may impact you and the United States as Canada is planning to regulate our supplements. To find out, please Google - "Q&A with CHFA's Aaron Skelton on how changing regulations for natural health products will impact retailers". Thank you Dr. Berg for your support! Reply @ygalel 10 months ago You don't have NMN Reply @9Crow 10 months ago my neighbor was a vegetarian and she swore that Spirulina was great. I don't know i suppose it is maybe. Who knows? Reply @nazdavidoff 10 months ago 5-10g of Psyllium Husk??? Thats insane, you know it expands in your gut, you must be having very strong bowels 1 Reply 3 replies @user-hm8nw4oc6y 4 months ago Instead of taking a low dose vitamin, eat some multi-grain cheerios every day Reply @Rikimkigsck 8 months ago Correction: Eight Supplements That I Sell Reply @Jean-PaulCh 8 months ago Brad: "I take ## of _ everyday" I can't imagine how many pills you are taking on a daily basis. Reply @xelaklement3367 9 months ago It would be interesting to know the gentleman's age Reply @MichaelAmen316 10 months ago The "other ingredients" in your MicroVitamin are terrible. =-( 2 Reply @Scuffed_Andy 8 months ago Why the hell would you want to lower cholesterol. That's old fashioned thinking. Catch up. 1 Reply Dr Brad Stanfield · 1 reply @Chris-bg8mk 9 months ago (edited) I find it very difficult to trust the advice of people who talk so much, so fast, and largely without breathing. Feels very much like a car salesman. 1 Reply @joeblow2183 10 months ago You are much younger than many of us. We don’t want to wait another 10 years for a definitive study. Why don’t you pretend you are 70. What about metformin ect? 1 Reply @baaaaaa2898 6 months ago Omega 3 :D :D :D Poisoooon Reply @GH-cd6oq 10 months ago Hey Doc - Just swallow your pride and admit you are wrong about NMN. Love your channel btw Reply @raajjji5486 10 months ago EGG KHIMAA KHAANA HAI ? ????? Reply @marthaadams8326 8 months ago Do you sell supplements - what about eating the real food??? Reply @liamjordan3068 10 months ago Creatine, 3 minutes or less exercise, basically sex then 1 Reply @moosaseedat9598 7 months ago Isnt your multivitamin unatural? Reply @carnivorelife152 7 months ago Eating just meat has the same thing Reply @ivobaren1 10 months ago first two creatine and the other one they are only useful for muscle building and strength other benefits not proven. How can you relate them to longevity??? I quit watching others after that. Reply @christineabercrombie7316 9 months ago i think this video is trying to gaslight me about some vitamins i bought. lol Reply @dodgerswschamp5166 10 months ago My diastolic blood pressure is around 57-61, not very high. Is it still safe for me to take psyllium husk? (I heard it can lower blood pressure.) Reply @frankiefernandez5252 10 months ago Only a small percentage of man-made supplements are absorbed. Reply @apollosun6268 10 months ago 1. Creatine Reply @christineabercrombie7316 9 months ago no thanks, but thanks. its in energy drinks isnt it? also you probably worried about catching someone smoking pot, you dont need to most people who smoke pot will just tell you with no shame whatsoever. Reply @kayumochi 10 months ago I am disappointed that Brad sells supplements. Yeah, I get that supplements are where the money is but it also taints the message. 115 Reply 17 replies @MssrProperties 8 months ago Really? 8 supplements? Mr. Sales go back to over coming objections. Reply @user-mu1in6el5p 1 month ago Bottom line, just eat healthy and exercise. Reply 1 reply @AidanAidanAAA 8 months ago Kiwi doctor, sweet as! Reply @BOBTEXUS 10 months ago Dr.first time to meet you thanks continue we Ugandans who are following you, we are to recover. Reply @HaHa-bu4ze 9 months ago You guy are how of this world how can peoples afford supplements when they have no food Reply @Martin_Z555 8 months ago pro tip: dont take supplement advice from a guy thats trying to sell them to you 6 Reply 1 reply @gregcarrick4785 9 months ago Just eat meat, no supplements necessary. 1 Reply @russianprincess3673 10 months ago From Beautiful Rich White Snow Bunny If your very lovely wife saw us together she would be very jealous. I will for sure visit you in NZ after the war. God 1st Yuliya ️ Reply @messenger_144 9 months ago Salesman 1 Reply @tmanthemotivator 10 months ago Can you comment on creatine causing kidney stones Reply @jamesmack3314 7 months ago Can he take a vitamin that fixes his voice? Reply @GUDDAisHere 10 months ago Why do you push statins? Reply Dr Brad Stanfield · 1 reply @RedArmyMedic 10 months ago 35 g of soy protein vs. 36 g collagen. YOU SAID 35 G OF PROTEIN. YOU MISSREPRESENTED. BE ACCURATE. Soy is crap. Pea, beef, whey, or egg would have made this a good study to reverence. What type of collagen did they test. That was a weak study, and you know it. Reply @Shakedown24Seven 10 months ago Man this guy is such a pharma-troll Reply @forest989 9 months ago Is this a vegan channel where people need supplements, or is this a supplement promoting channel? What about throwing out the supplements and eat whole foods? Just asking... Reply @Stone46988 8 months ago Just eating meat. I eat beef and that's it and I've never felt better. You just piss supplements right out anyway. Waste of money the best way to get nutrients is through food. 1 Reply @snake1625b 10 months ago Is it just that burn study that compared protein powder vs collagen for skin health? I'm speculating that results on burn victims might not translate to the general population? Reply @mariakaraivanova6690 10 months ago Did $cience and $tudies say so? Reply @smoakpipe 10 months ago (edited) what about nicotinamide mononucleotide, resveratrol and metformin? 1 Reply @michaeldavis6607 9 months ago Nobody on YouTube talk normal anymore. 16 Reply 3 replies @Hasanafandi-qj6oh 4 months ago Untrue, only eat less live long. Reply @visco154 10 months ago The CARNIVORE lifestyle is the best way to get all your supplements. It is the ultimate way. 1 Reply @alans177 10 months ago Reply @russianprincess3673 10 months ago From Beautiful Rich White Snow Bunny 🇷🇺🇷🇺🇷🇺🇷🇺 Wonderful very truthful video. 100% on target. God 1st 🇷🇺️ Reply 2 replies @thebob5568 10 months ago blah blah blah blah blah 2 Reply @finalfan321 10 months ago your multivitamin doesn't look that great though :s 1 Reply 1 reply @googlesucks1 10 months ago God, no, the custom multivitamin shilling begins. 3 Reply @hakuna1392 8 months ago he's worse than big Pharma and Bill Gates and the World Health Organization. Reply @troygallagher9242 10 months ago Omg so boring Reply @MarkZiegler 5 months ago He seems to cherry pick his studies. 1 Reply 1 reply @charlessavoie2367 9 months ago Why this constant euphoric grin all the time, you high, revved-up on something? Dismal, you sound like a BRITISHER! Reply @ramprabath7352 10 months ago First comment Reply 1 reply @Sh4dow682 7 months ago These videos are just repeating themselves.. started from the earliest videos to now and yeh very repetitive. Reply @ayo9057 10 months ago Creatine makes humans retain water. No thanks Reply 5 replies @bogse 10 months ago This guy is talking same BS week after week.. nothing new to say??? 2 Reply 1 reply