Why Taking Care of Your Mitochondria is SO Important

Why Taking Care of Your Mitochondria is SO Important Commune 151K subscribers Subscribe 4.4K Share Download Thanks Clip 133,920 views Aug 22, 2023 Commune Podcast: Full Episodes Mitochondria produce 90% of the energy our bodies need, but many of us are eating food that disrupts their function, leading to symptoms like fatigue and brain fog. Dr. Steven Gundry, Dr. Casey Means and Dr. Robert Lustig are some of the world’s leading experts on mitochondrial health. In this episode, we explore the ways in which we’re poisoning our mitochondria and what we can do to repair the damage. In this episode we cover: 00:03:03 – Mitoclub Analogy 00:15:15 – Impact of Excess Blood Glucose 00:20:02 – Fructose 00:21:21 – How to Support Your Mitochondria 00:25:19 – Mitochondria 101 00:27:37 – Foods that Poison Your Mitochondria 00:29:31 – 3 Key Takeaways Learn more about Commune and check out all our health, nutrition, and functional medicine courses free for 14 days at onecommune.com/trial CONNECT WITH US Instagram: / onecommune Facebook: / wecommune Twitter: / onecommune ABOUT COMMUNE At Commune we explore the ideas and practices that help us live healthy, connected, purpose-filled lives. Each week host Jeff Krasno speaks with teachers, spiritual leaders, doctors, and storytellers on topics related to personal and societal well-being — from nutrition and integrative medicine to spirituality and personal growth to environmental regeneration and civic engagement. Commune is also an online course platform with more than 125 full-length video courses with top teachers such as Deepak Chopra, Marianne Williamson, Dr. Mark Hyman, Adriene Mishler, and many others. 14-DAY FREE TRIAL Commune Membership helps you nourish your mind, body, and spirit with daily video lessons and practices designed to help you live life well. Start your free trial today: https://www.onecommune.com/try-commun... Key moments View all Explore the podcast 254 episodes Commune Podcast: Full Episodes Commune Podcasts Transcript Follow along using the transcript. Show transcript Transcript: Intro 0:00 anything that's hurting my mitochondria is making me less metabolically healthy 0:05 there's one word that your listeners need to walk away with and understand its mitochondria 0:12 we are on a mission to inspire heal and bring the world closer together 0:19 welcome to commune my name is Jeff krasno today we're discussing 0:24 mitochondria and their vital role in human health 0:29 so mitochondria are we small organelles in the cell that produce energy 0:35 otherwise known as ATP or adenosine triphosphate from the food that you eat 0:42 and the oxygen that you breathe and they do this through a process known as 0:49 cellular respiration which has three stages number one glycolysis number two 0:56 the citric acid cycle aka the Krebs cycle and number three the electron 1:04 transport chain now these fascinating Jelly Bean shaped structures actually 1:10 have their own genetic material all of which you inherit from your mother and 1:17 that's distinct from the DNA in the nucleus of the cell now their origin 1:24 goes back billions of years when a prokaryote archaea engulfed a purple 1:30 bacteria and this romantic tryst birth aerobic respiration essentially the 1:37 production of energy with the use of oxygen and this springboarded complex 1:42 life it's pretty amazing the mitochondria in our cells animate 1:48 literally everything that we do from the conscious viewing of this video to the 1:55 unconscious digestion occurring in your gut now each cell in our body with the 2:02 exception of mature red blood cells contain mitochondria and a different 2:08 number of them your brain cells your neurons your cardiac cells Brown fat and 2:14 muscle cells both the highest concentrations of mitochondria and that 2:20 makes good sense given the significant energy requirements of those cells 2:27 so in this episode we'll be hearing from three brilliant doctors Dr Stephen 2:32 gundry my dear friend Casey means and Robert lustig as we explore how 2:37 mitochondria function and occasionally dysfunction now our first guest is Dr 2:44 Stephen gundry he is a physician a former cardiac surgeon and a researcher 2:50 who investigates the impact of diet on human health now he's going to set the 2:56 stage for our discussion with his helpful and humorous metaphor that 3:02 explains mitochondrial function he calls it the Mido Club 3:07 without further delay here's Dr Steven gundry okay so I think this is a good time to Energy Production 3:15 talk a little bit about energy production in the body 3:21 um and the mitochondria and you use this absolutely hilarious and very fun 3:27 metaphor in the book uh with the nightclub analogy the Mido Club yeah so 3:34 um so the electron transport chain which was proposed by Sir Peter Mitchell who 3:42 also finally won the Nobel Prize the electron transport chain uh 3:48 simplistically I call a nightclub that has an entrance on one end of the 3:55 nightclub and an exit on the other end of the nightclub and 4:01 20 somethings which will which we'll call Energy substrates like glucose like 4:08 proteins like free fatty acids uh enter this nightclub you know I call it the 4:13 Mido club and it's the hippest hottest place in town and they go there for one 4:19 purpose and one purpose only and that is to couple with oxygen 4:25 and if they couple with oxygen then they 4:31 leave the nightclub via a one-way revolving door and this is the process 4:38 of leaving the electron transport chain coupled uh produces ATP literally very 4:46 much like water going over a water wheel producing energy 4:51 and there's only one way out and in this nightclub the the electron transport 4:58 chain is is really changing energy levels of electrons and 5:04 protons it's getting them excited and we laugh in longevity that you know the 5:11 only purpose of life is to move an electron from one level of charge to another but I digress so so things and 5:20 believe it or not this club is hot it's steamy it's sweaty there's so many hormones going on 5:27 drinking and all for the purpose of getting this coupling going well 5:33 that's all well and good but the process of coupling uh has a lot of side effects 5:39 there are fist bites there is a lot of drunken craziness and we actually have 5:45 bouncers in the nightclub and people probably know at least one of the 5:51 bouncers it's glutathione the other bouncer which is a surprise to almost everybody is melatonin and it's a 5:58 surprise almost everybody that we only have two antioxidants that actually work in our mitochondria glutathione and 6:04 melatonin but we'll digress for a minute in the process of looking to couple up 6:10 electrons will also just because everybody's Rowdy will couple with 6:16 oxygen by if you will mistake and we now know that that coupling process produces 6:24 free radicals produces reactive oxygen species and while some of those are 6:31 pretty good they make it pretty interesting place to be a lot of them we now know is one of the major processes 6:38 that damage the club the mitochondria and pretty soon you know you've got beer 6:45 all over the place of broken chairs and it's no longer the hip place that you 6:51 want to be so that's how the electron transport chain works and part of what glutathione 6:59 melatonin do is to Tamp down this unwanted coupling if you will and try to 7:06 get oxygen into couple with protons and make some CO2 and head out the door 7:12 what was fascinating to me when when Peter Mitchell proposed this a lot of 7:19 very smart chemists chemista no weiner the process of making ATP using this 7:27 system using mitochondria you should take one molecule of glucose and always 7:33 get 32 molecules of ATP every time it's a chemical equation ATP Production 7:40 and you know and Peter Mitchell said well wait a minute you know you guys are all running these experiments with 7:46 isolated mitochondria and guess what you know sometimes we're getting 28 7:53 molecules right yeah yeah and what's happening to those guys 7:58 so it wasn't until really when his theory was accepted that almost Simon 8:03 and we got the Nobel Prize on I think in 1978. almost simultaneously uh three 8:10 researchers said you know he's right about all of this but what's 8:16 missing is well where were these why what weren't we getting 32 molecules of 8:21 ATP so they proposed that there were literally emergency exits along the 8:29 electron transport chain that were controlled by what were called uncoupling proteins that could literally 8:37 open the door of an emergency exit and let protons 8:43 escape from the club instead of going all the way down through the revolving 8:50 door and they proposed that these Escape hatches and there were 8:56 five of them would be why in all these experiments 9:01 you never got to that magic number of 32. and so when I learned about uncoupling 9:09 proteins uh and I started putting two and two together if I realized that 9:16 a great amount of the calorie potential to produce energy 9:23 was automatically being wasted and net out of the electron transport chain and 9:30 in fact I didn't know this but 30 percent of all 9:35 the calories that we eat never make it into ATP production they 9:42 are wasted out piece emergency exits in the Mido Club 9:48 so now you go well wait a minute if you're designing an animal that's really stupid because now he basically has the 9:55 30 more food just to produce the energy to stay alive 10:01 so what's the deal well one of the deals is in the process of letting these 10:07 protons Escape From The Globe they produce heat and we happen to be 10:13 warm-blooded animals and believe it or not even cold blooded animals depend on 10:18 this to keep their body temperature and so heat production is an important part of this 10:25 but what became apparent and will go into dnp in a minute 10:30 is that you could waste a lot of calories by opening up these emergency exits you 10:38 could literally do a caloric bypass well it just so happens that ketones 10:45 aren't some phenomenal fuel it turns out the ketones are a phenomenal signaling 10:52 molecule that actually among other things actually do three things they tell 10:59 mitochondria to waste fuel to open up these emergency 11:05 exits which on the surface seems are really stupid to do because ketones 11:11 original purpose was to be produced during starvation to keep the brain kind 11:17 of hanging in there until food arrives and it would make no sense if you're 11:22 starving Adele to waste fuel and then I 11:28 stumbled upon an obscure paper by Dr Martin brand and the paper was 11:34 published in 2000 I recommend it to anybody because it's actually a easy read 11:40 and the paper is simple uncoupled to survive and the name of the paper and he said 11:50 inextremists at all costs mitochondria has to protect itself from Death because 11:59 if the mitochondria dies it doesn't matter what happens to the muscles it doesn't happen to anybody else 12:05 you're screwed so the mitochondria should do everything in its power to 12:11 protect itself so stepping back for a second producing energy is really costly it's really damaging a mitochondria the 12:19 club becomes a mess so if we actually waste some of all these people 12:26 entering the club the place calms down so that's number one 12:32 number two it's okay to waste energy but you got to 12:38 have a certain amount of energy production or things fluttered to a stop so it turns out the ketones and other 12:46 substances actually tell mitochondria not only to waste some of the stuff out 12:51 the side door but to make more of themselves to share the workload 12:57 now it really starts to make sense because okay you're protecting each individual mitochondria by having it 13:04 work less but you're simultaneously adding more mitochondria to take up the 13:09 workload each at a reduced work uh I'll give you an example let's say we have a 13:15 dog sled since it's now winter and we have a two dog sled pulling a guy and 13:22 they're doing a lot of work if we add six more dogs we now have an eight dog 13:27 sled each of those dogs now has to do about a quarter of the work that the two guys 13:33 did but you're gonna get you know you're gonna go as fast probably faster 13:38 so it actually makes sense to have a program to make a lot more mitochondria 13:43 when times are tough and for instance most people have heard of brown fat 13:50 Brown fat is brown because it's so packed with mitochondria that it's 13:56 literally Brown and brown fat turns out is actually one of the keys to lifelong health and brown 14:04 fat produces heat and we can actually see it so mitochondria protect 14:09 themselves they build more of themselves called mitogenesis and the third thing 14:14 that happens from ketones is it literally instructs mitochondria to repair themselves to do the maintenance 14:22 that's needed to keep them in Tip-Top conditions and so as I talk about the Mido club uh 14:30 the Mido club owner actually wants less people in his minor Club to a 14:37 point where it's placed to be but he doesn't want to lose those customers so 14:44 he builds more mid Oklahoma to take up the slack yeah so like you say I carry 14:50 the analogy to its final end Hopefully Dr gundry's Mito Club metaphor Glucose Metabolism 14:56 helped you understand how mitochondria function as the energy producers of your 15:03 cells and this next segment we'll learn more about glucose and what happens when 15:10 too much of it shows up at the club now here's a quick primer on glucose 15:17 metabolism your body generally uses glucose from carbohydrates to generate 15:24 energy in the form of ATP adenosine triphosphate how glucose is absorbed 15:31 through your small intestine and into your bloodstream and then ushered to 15:36 your cells by a peptide hormone called insulin which is secreted from your 15:43 pancreas now if you have too much serum glucose because you scarf down a 15:49 milkshake with a bowl of pasta and a pizza and some ice cream well your pancreas will need to produce more 15:57 insulin to accomplish its job and if this pattern continues over time then 16:02 eventually your cells will become stingy about letting glucose into the club and 16:09 you'll become insulin resistant now when high levels of glucose are abandoned in 16:16 the bloodstream a few things can happen including number one some glucose can 16:23 get stored in the liver as glycogen essentially stockpiled for a rainy day 16:29 number two glucose will get converted into triglycerides and stored in adipose 16:35 tissue or fat number three glucose can combine with 16:41 hemoglobin the protein in your blood that's famously tasked with shepherding 16:47 oxygen to your cells to form an inflammatory glycoprotein 16:53 oh high blood sugar levels are concomitant with diabetes which is 16:59 correlated with cardiovascular disease and dementia in short this is why sugar 17:05 can be considered the world's most dangerous assassin 17:11 a Dr Casey means the expert for our next segment is a Stanford train physician 17:16 and the chief medical officer and co-founder of metabolic Health company levels now she reveals the downstream 17:24 impacts of excessive glucose and fructose on your mitochondria and shares 17:31 protocols that you can Implement to repair that damage and here you have the 17:38 esteemed Dr Casey means what happens when we have excess glucose Insulin Resistance 17:45 in our bloodstream and what are some of the downstream or knock-on impacts of 17:50 that glucose is blood sugar of course and for that to be taken out of the bloodstream 17:55 into the cells to be processed or stored it requires in most cell types insulin 18:02 which is like a lock and key that when when glucose comes into the bloodstream and Rises the pancreas releases this 18:08 hormone insulin which then binds to the cell receptor and allows for the glucose to to come in the glucose then is going 18:17 to be transported to the mitochondria and this is the key thing anything that damages the function of the mitochondria 18:24 is going to essentially create a backup of glucose in the cell that's ultimately 18:29 going to also signal for this process called insulin resistance to happen and insulin resistance is a sort of 18:36 protective mechanism of the cell saying we're not able to process all this glucose so stop putting it in the cell 18:42 so the cell becomes less sensitive to that insulin signal and therefore what's 18:48 going to happen is less glucose is going to get into the cell you're going to start seeing that rise is in the bloodstream and this block to insulin 18:55 you know it's sort of like the the salsane like there's no room at the end and so like we're gonna help protect the 19:01 cell from more coming in because we can't we can't host it so then you've got to think about well what are the things that are going to potentially 19:08 make the mitochondria not able to process that glucose um and one of the it's interesting like 19:15 one is just what we were talking about before which is have it just over um being asked to produce to process too 19:24 much glucose but there's other things and really anything that creates oxidative stress so too much free 19:31 radical activity in the cell can also really hurt the mitochondria so this is 19:36 a way that insulin resistance and problems with glucose can arise actually separate from just over glue too much 19:43 glucose in the body and that are really important to zero in on and I think a framework to think about is like anything that's hurting my mitochondria 19:50 is make give me less metabolically healthy because then you open it up from it's just sugar that's causing diabetes 19:57 and obesity to actually there's a whole world of things that can impact the mitochondria and lead to these problems 20:02 so for instance like um interestingly fructose which is not 20:08 glucose but it's you know what's found in high fructose corn syrup and what's found in 20:13 um juice and and you know in high levels in these foods that are refined um fructose products so interestingly as 20:20 fructose even though it will not raise glucose in the bloodstream it will be processed by the cell in such a way that 20:28 it generates a metabolic byproduct called uric acid and uric acid is a molecule that 20:35 actually creates oxidative stress in the mitochondria so even though this is glucose independent it's creating a 20:41 problem in the mitochondria which is then telling the cell we can't process all this glucose become insulin 20:47 resistant so oxidative stress can happen and uric acid is one example of course oxidized other oxidized Foods so we hear 20:54 a lot about oxidized seed oil so these like vegetable oils and Seed oils that 21:00 are prone to oxidation those can also hurt the mitochondria and stress can can 21:07 do this as well it can generate damage in the mitochondria so that's just to 21:12 say there's sort of a holistic world of things that can impact the mitochondria that can lead to problems with how the 21:18 cell is processing glucose and cause glucose to rise in the body and then you hear about all these um you know sort of 21:25 things that people are doing now to kind of improve their health the sort of biohackery type things like cold 21:30 plunging and saunas and intermittent fasting and I think it's interesting to 21:35 just touch on this really quickly because in many ways these are helping by impacting the mitochondria when we're 21:43 fasting when we are putting um the body into cold stress when we do 21:49 you know high intensity interval training or zone two training actually lower intensity longer periods of 21:55 training what we are doing is building we are stimulating the body to build more mitochondria so insulin produced in Oxidative Stress 22:03 the pancreas picks up glucose and ushers it to cells for energy production muscle 22:08 cells are actually an exception they don't require insulin for glucose uptake however in general the more glucose in 22:16 the bloodstream the more insulin is required eventually excessive insulin 22:22 will lead to cells becoming insulin resistant the cells no longer accept 22:28 glucose and it remains in the bloodstream the sum of the excess glucose as I mentioned earlier can get 22:35 stockpiled as glycogen in the liver however much of it is stored as 22:41 triglycerides in fat cells now glucose can also bind with proteins like 22:47 hemoglobin in the bloodstream to form inflammatory Advanced glycation end 22:54 products also known as ages and these molecules can damage the vascular system 22:59 and set the stage for cardiovascular disease 23:05 excessive glucose in the cells can lead to the overproduction of free radicals 23:11 these highly reactive molecules that can damage the mitochondria and cause 23:17 oxidative stress so the term oxidative stress is used to describe the condition 23:24 of damage resulting when the critical balance between free radical generation 23:30 and antioxidant defenses is unfavorable oxidative stress is involved with a 23:38 whole wide host of physiological and neurological disorders including cancer 23:44 heart disease Parkinson's autism depression and many others in the case 23:50 of cancer for example free radicals can induce DNA damage or mutation which can 23:57 lead to the production and proliferation of dysfunctional cells so hopefully this 24:03 provides you with enough reasons to avoid refined sugars and starches 24:09 so our next guest Dr Robert lustig is going to reveal some of the common foods 24:15 that we eat that may be contributing to that oxidative stress and poisoning our 24:22 mitochondria so by the end of this episode you'll have a solid list of foods to avoid the next time you're at a 24:31 grocery store couple those with Dr means suggestions on how to repair your mitochondria from the last segment and 24:38 you'll have a good running start so Dr lustig is a pediatric endocrinologist 24:44 and professor emeritus at the University of California San Francisco and he takes 24:50 the information Dr means shared and broadens the scope while keeping it bite-sized in this next segment and with 24:58 that I give you Dr Robert lustig maybe you could begin by outlining the Mitochondria 25:05 primary chronic or non-communicable diseases and give us just a sense of 25:11 scale in terms of the health economic and planetary costs associated 25:16 with these diseases okay if there's one word that your listeners need to walk away with and 25:23 understand its mitochondria now if you took 10th grade biology you 25:31 learned about the mitochondria okay it is an essential component of uh high 25:37 school biology education problem is you haven't heard of it since and you need to it's the most important 25:45 part of the cell you hear about the nucleus all the time because that's where the DNA is and everybody's into 25:50 genetics well if this is actually a bigger problem than genetics mitochondria are 25:58 the little energy burning factories inside each of our cells glucose is the primary energy source but 26:06 there are other energy sources as well such as fat ketones 26:13 amino acids alcohol and of course fructose which we will get 26:20 to in a minute all right but glucose is the primary energy source and there are two steps to Turning glucose into energy 26:28 to power the cell the first step is called glycolysis that's what yeasts do fermentation 26:36 that's the difference between wine and grape juice and the second is 26:43 what we call aerobic respiration mitochondrial function and that's where 26:48 the majority of the atps the adenosine triphosphates the chemical energy that 26:55 food gets turned into that powers the cell gets done when your mitochondria work you make 27:02 lots of ATP and that's what your cells want to do especially brain cells because they use a lot of ATP because 27:09 neurotransmission is ATP energy intensive ATP intensive and there's no 27:15 place to store energy in the brain because I mean you need you need your 27:20 neurons for work not for storage okay so you need a steady supply of glucose and 27:27 you need a steady supply of energy and you need a steady supply of mitochondrial function in order to make 27:34 your brain work right well anything that disrupts mitochondria 27:42 is going to end up causing disease and it turns out that there are 27:50 chemicals in our environment that do that cyanide does that but you know cyanide's 27:57 a poison we know it but there are a lot of things that do it that aren't considered poison but they are because 28:05 they disrupt mitochondrial function okay trans fats do that and they are poison 28:11 we know that now but we didn't know it for a hundred years you know the first trans fat was made in 28:18 1902 Crisco was patented in 1911 and by 1920 virtually every baked good in 28:24 America was you know made with trans fats because trans fats didn't go Rancid 28:31 vis-a-vis the 10 year old Twinkie all right Bill turns out the trans fats 28:37 actually poisoned your mitochondria well alcohol poisons your mitochondria and branched chain amino acids poisoning 28:43 around the country and it turns out fructose this sweet molecule in Sugar poisons your mitochondria too 28:51 and so if you can't get the ATP out of your cell you're going to have 28:57 cell dysfunction and ultimately cell death when you have cell deaths guess what you have human death too 29:03 so keeping your mitochondria on its tippy toes and working as efficiently to 29:10 generate the most energy possible is a prime directive of Health Conclusion 29:16 hopefully our experts in this episode inspired you to take care of those tiny organelles that have such a big hand in 29:24 taking care of you here are some key takeaways from today's episode number 29:29 one the dysfunctional metabolism of glucose can produce an excessive amount 29:35 of free radicals in the mitochondria and this can degrade mitochondrial function 29:41 and negatively impact energy production okay number two nurture your 29:48 mitochondria by consuming healthy fats high quality protein vegetables and 29:55 fiber and limit your consumption of sugar and of starches 30:01 number three Implement lifestyle practices like intermittent fasting or 30:07 cold hydrotherapy that stimulate the body to produce more mitochondria this 30:14 is called mitobiogenesis okay I hope you enjoyed this episode and 30:22 if you did please subscribe and hit the notification Bell so you'll never miss 30:27 another show leave a comment to let us know your thoughts and don't forget to 30:33 share our content with others who might benefit from this valuable information 30:39 and the great experts that we assemble here on commune okay that's all from the 30:45 commune for today my name is Jeff krasnow and I am here for you 30:51 Commune 151K subscribers Videos About Instagram Facebook Pinterest Twitter 1:41:46 Why Blood Sugar Matters with Dr. Casey Means by Commune 1:09:19 This Doctor Reveals Why People Fail On Keto Diets | Dr. Steven Gundry by Commune Try Commune Membership Free for 14 Days Join Now 216 Comments rongmaw lin Add a comment... @lilytea3 10 months ago 0:33: Mitochondria are small organelles in cells that produce energy through cellular respiration and have their own genetic material. 5:04: ! The nightclub-like electron transport chain in mitochondria is responsible for changing energy levels of electrons and protons, with glutathione and melatonin acting as bouncers to regulate the process. 10:18: Ketones play a crucial role in signaling mitochondria to waste fuel and open emergency exits, helping regulate body temperature and heat production. 13:54: Mitochondria play a crucial role in lifelong health by producing heat, protecting themselves, and repairing themselves. 18:31: Insulin resistance is a protective mechanism of cells to prevent excessive glucose uptake, but it can lead to elevated blood glucose levels. 22:25: Excessive glucose in the bloodstream can lead to insulin resistance, inflammation, and oxidative stress, which are associated with various health disorders. 26:46: Disruption of mitochondrial function can lead to disease, particularly in the brain which requires a steady supply of ATP. Recap by Tammy AI 61 Reply 6 replies @mirzamanmirzaman1482 11 months ago I never listen to Gundry but I listen to Dr. Lustig a lot. His knowledge is very high and I have learned a lot from him. 95 Reply 10 replies @FielValeryRTS 10 months ago Listened to Dr. Lustig's 2-hour lecture several times World-class scientist with a clear message 31 Reply 1 reply @sl4983 3 days ago I love how Dr Gundry describes the mitochondria coupling Reply @Dolphin_457 2 months ago I love Dr. Lustig's lectures and videos. He is brilliant and an expert in the evils of sugar and fructose, insulin, insulin resistance, ultra-processed carbohydrates, fats, metabolic syndrome and all its related diseases such as diabetes, hypertension, CVD, insulin resistance, dementia, immune diseases, kidney disease and cancer, and he says that all diseases start with Mitochondrial dysfunction at the level of liver cells, which cause a fatty-liver, which cause insulin-resistance which in turn leads to all the degenerative diseases mentioned above. I read Dr. Lustig's two books: Metabolical, his best-seller FAT Chance, and watched his best lecture, Sugar : The Bitter Truth. Thank you, Dr. Lustig, you are saving lives. 3 Reply @roberta_laurie 2 months ago These interviews helped me put the pieces together. I'm beginning to understand the nuances of mitochondria dysfunction in a way I didn't think was possible. 3 Reply @137997311ful 11 months ago (edited) You are what you eat! You become what you eat! 7 Reply @donnam2012 7 months ago I got my pen and paper for the promised list of "eats" and "do not eats" for the grocery store, as promised, but did not hear Dr Lustig give that. He did say trans fats are bad, but these are not in foods where I live (Australia) nowadays. 3 Reply @luzvimindabacica4988 3 months ago I loved to listened Dr.Lustig, I've learned a lot from him, without buying products. 1 Reply @dvdv8197 11 months ago Everyone here's bashing on Gundry, meanwhile here I am thinking what he said was super interesting. ️ 19 Reply 5 replies @goldarua3802 10 months ago Excellent simple understanding of how our bodies work. Thank you. 6 Reply @kenadams5504 11 months ago (edited) Just eat wholefoods and avoid processed foods ,(as much as possible). 15 Reply 1 reply @ramkrishn4762 10 months ago One cardiologist fairly said just stop glucose in take for 14 days; see the difference. 11 Reply 1 reply @susanshewmake1430 8 days ago I like Dr Gundry I take some of his products he has helped me out on my journey Reply @sneakypress 9 months ago (edited) Very well—written, and presented, introduction. 4 Reply @ok4076 3 months ago Thank you for your recommend. 1 Reply @gklein4054 8 months ago Thank you for being these professionals together for us to hear their wisdom, and especially yours and the way you describe things and lead to the next guest this is not mirror entertainment. This is a primer for how to stay healthy and prolong your life. Thank you once again. 4 Reply @margomoore4527 5 months ago Since he was speaking on neutral matters, Dr. Gundry was—in this instance—able to speak cogently and clearly about what happens in the mitochondria. I found this helpful in understanding what goes on in our bodies. Reply @teresayoung1138 10 months ago Eat meat, salt, water..... #carnivore 5 Reply @AlistairAVogan 10 months ago Excellent curation. Very informative. 4 Reply @jennysteves 11 months ago Excellent video. Thank you! 11 Reply 1 reply @rajeshtanwar2445 11 months ago Insightful and valuable discussion covering various aspects of mitochondrial function and dysfunction and it's resultant impact. 8 Reply @19battlehill 5 months ago The Mitochondria STARTS TO USE GLUCOSE INSTEAD OF OYGEN --- Why are you NOT TALKING ABOUT THIS?????????????????????????????????????????????????????????????????????????????????????????????? 3 Reply @majaber1 7 months ago Wonderfully precice, concise detail about mitochondrial health. Thank you, Iv subscribed. 2 Reply @tramboithao 10 months ago Lustig is the bomb 12 Reply @galahadthreepwood 9 months ago No one mentioned deuterium, which damages the mitochondria in its nano motor complexes that undergo respiration. This vastly lowers energy efficiency, and plainly relates to metabolic issues, like obesity, cancer. See this on Youtube: "Can Deuterium Damage Your Metabolic Health and Mitochondria?" 8 Reply @19battlehill 5 months ago Did you know EVERY CANCER CELL (no matter if it is lung, liver breast, brain) does the same thing? Something is triggered in the mitochondria that is stops using oxygen as energy and it starts to use glucose (sugar) -- this is why when you starve the body of glucose the cancer cells die. Cancer cells need SUGAR. Regular cells can use ketones and don't need sugar - cancer cells can't. Only problem is the your body makes glutamine - which is form of glucose. Cancer could easily be cured and it is purposely NOT CURED. Why? Because hospitals make billions on treating cancer. They don't want to find a cure. 4 Reply @thurgooddukes7381 8 months ago (edited) The first Doctor confused the heck out of me with his "club" metaphor! 7 Reply @MendeMaria-ej8bf 10 months ago Thank you a lot for sharing your knowledge to the lay public. 5 Reply @contrarian717 10 months ago Had energy problems for 5 years when I went HFLC Nov2018. Turns out I ate too little fats. I was barking up wrong trees for 5 years (testosterone, thyroid, electrolytes, and a few other silly things). 9 Reply 6 replies @StarvingMyselfToLIFE 11 months ago Master Class! 3 Reply @zen00me 11 months ago Thank you for all excellent info. 5 Reply @jamesboyle806 6 months ago First time on this channel, fabulous presentation all round,very impressive making such a complex abstract understable to the public.The structure of the introduction and presentation is A1,well done,much appreciated! 1 Reply @pramujisinggihriyanto6901 10 months ago I really enjoy this content. Three experts share their favorable knowledge... I really owe you these sharing of knowledge on mithocondria... GBU 7 Reply @user-ox5li9gt9b 11 months ago Very good video thanks 4 Reply @catherinebell122 8 months ago Love this session! 1 Reply @davidfoster7119 7 months ago I find it interesting that Dr Lustig stated that BCAA damage mitochondria, at what level of consumption does that happen? All protein sources contain BCAA, leucine is a major driver of protein synthesis...where is an in depth explanation of how this occurs? 1 Reply @avashavash1594 11 months ago Thank you for your explanation, but showing foto or some kind of picture of these mechanizem proces in the body,will make more understandable and not forgotten. Thank you again. 6 Reply @auntiebarnes 11 months ago Well done! Thanks! 4 Reply @andekay 5 months ago Thankyou for sharing this mitochondria info. I have a question, why do you have a problem recognizing that our remarkable bodies were designed by an awesome Creator--rather than fabricating a faulty fairy tale about how intelligent humans came then lower life forms? 2 Reply @sl4983 3 days ago Who did you make Dr Gundrys audio sound so poor quality? Reply @JennyB957 6 months ago (edited) The video was definitely a strain for my afternoon brain to comprehend and retain. But so point a to point b . Reply @afsipena4138 11 months ago Thank you ! 1 Reply @jimmycutter4307 10 months ago Great job thanks! 1 Reply @FoCoCo750 1 month ago I'm also in the anti- gundry sentiments. He's not in the same league as dr's lustig & casey means intellectually, in sophistication and vreativity of thought, and his lengthy track record has shown that he gives teaser info, just enough to hook people in to paying him to get enough info to make a difference. Lustig & Means have consistently been about helping people by generously providing all tge info so people can help themselves and by generously giving time in a ctivism at government levels to effect policy change (and other ways too numerous to mention). 1 Reply @santoshkumarsingh8432 8 months ago PRANAM SIR Reply @annehenderson462 10 months ago Thank you for key takeaways. Reply @user-dc6cm1iu3j 11 months ago Did dr robert lustig say Branch chain amino acids damage the mitochondria ? 3 Reply 1 reply @polianaisabel27 7 months ago Dr Gundry is the best! He has the courage to say the things that nobody wants to hear Reply @tube1062 3 months ago 22:07 Muscles don't require insulin for glucose uptake.? From Gemini AI: "Muscle cells: Both skeletal muscle and cardiac muscle rely heavily on glucose for energy. Insulin promotes the movement of special transporter proteins (GLUT4) to the cell surface, allowing glucose to enter the muscle cells. Muscle cells can still take up some glucose even without insulin, but at a much slower rate." Reply @Pops2 7 months ago 1:41 that may be a leap of faith sir. Reply @evelynodonnell2583 11 months ago The takeaway conclusion at the end mentioned the importance of fiber, but i don't think any of the three guests mentioned fiber at all, did they? 4 Reply Commune · 3 replies @1aliveandwell 9 months ago How do we check how our mitochondria are? by certain labs or genetic test of MT snps? If are fatigued can we test by oximeter or thermometer (can make enuf heat), ................?? So we dont want excess glucose (protein?, vegie?, fat?) ? ? Glucose and fructose mentioned does that mean watermelon, pear....? 1 Reply @Marshadow69 11 months ago How does the Randle cycle play into this. I am wondering about the segment with Casey Means. 1 Reply @FoCoCo750 1 month ago OMG! Only 2 min's of Lustig??? He should have been the top star of this show! He and Dr. SIEGFried (sp?) have been the primary developers of this metabolic perspective! You wasted so much time with Gundry, who shouldnt even have been included. Next time, more Lustig, more Casey, and other stellar people, plz. 2 Reply @luckssj 11 months ago The trouble is that the nutrient density is going down. 6 Reply 1 reply @neelamkaur1965 10 months ago Unfortunately only 6 minutes given to Dr Lustig I am not pressing the like button 5 Reply @pramujisinggihriyanto6901 10 months ago We need info on how we can improve our metabolism.... 1 Reply 1 reply @elinmansson5535 11 months ago Not a fan of Gundry, I had to fastforward the video to de lustig 172 Reply 40 replies @darrelllf851 11 months ago (edited) GUNDRY ??? I can't trust anything he says, after he already fooled me once in the early days of his lectin sham to sell books\supplements. He's just sad. Frankly, I'm rather surprised you would have him on your show. 27 Reply 5 replies @frithar 10 months ago A little.insulting to have Gundry on the same bit as Dr Lusting. Lusting is world class. Gundry...ehhh, not so much. 12 Reply @serminboekhoven2994 7 months ago Why bdy is choosing the third option to bind excess glucose bind with proteins like hemoglobin in the bloodstream to form inflamatory advanced glycation end products. I understand this is aging but why body not stays in the second option and acumulates more and more fat instead continues to the third option. I ask this because I believe we are our body has a very intelligent being, it does do everything with a good logic, to protect itself, then how can he damages itself in this way. Reply @martykerns3802 11 months ago Sorry, can’t listen to Guidry. Please, sir, get to the point quickly! 12 Reply @blinkyschannel 5 months ago Awesome episode, it's unfortunate that you ended with eat your veggies and fiber… Reply @user-nh9hd2zi1e 3 months ago Love Casey Means!!! And Lustig is always good 1 Reply @MichaelRWright 9 months ago Liked and Subscribed (ALL) Reply @donnabrown7239 8 months ago Gundry will never be the dr Lusting is 2 Reply @Zomfoo 2 weeks ago I don’t have the energy to put your advice into practice. Reply @retribution999 10 months ago (edited) An apple a day!.. It used to be so simple. Now its become impossibly complicated. Quit sugar, eat wholefoods, eat an apple a day, do some regular exercise and drink pure clean water. You dont need much more than that. 4 Reply 4 replies @haystack1739 8 months ago Prof Bart Kay does a way better job explaining the Kreb cycle and Randall cycle. So does Physionic. Reply @michaelweber2566 6 months ago Move to Minnesota if you want a lot of cold therapy Reply @sharielizabeth 4 weeks ago Too many medical terms cant understand Reply @faithevrlasting 9 months ago (edited) Not a fan of gundry either. Took a Gunxry md supplement whichcaused me a side effect of a mental health issue. It was a known side effects howsver wasnt warmed anywhere on the jar, their web site or infomercial. Thankfully I was able to get a full defund. It should however been revealed. I am a MSN prepared 50 yr RN so I knew where to research it. 2 Reply @jamesh3832 8 months ago Lustily said bcaa’s poison your mitochondria. These are essential dietary nutrients. Idk how that makes sense. 1 Reply 1 reply @shraddashradda 10 months ago Listening to this I’m having visions of the Bodyguard…Kevin Costner being Glutathione 1 Reply 1 reply @sean.durham999 10 months ago BCAAs poison your mitochondria? Reply @murdermittensnyc 7 months ago Youre a bit misleading about what each segment included. Around min 17 and min 24 you say that Dr Means offered suggestions on “how to repair your mitochondria” and protocols to repair … as she put it she touched briefly on what some people are doing to biohack but that does not constitute a “protocol” as you put it. Its not even in the realm of suggestion. I applaud her work but was very disappointed with your representation of her talk. Ditto Lustigs talk. He didnt present a list of foods or even conceptually close to that yet you referred to his talk as something we could use when shopping in the grocery store. Did you even listen to their talks? Did you edit out the useful bits? You created bogus expectations. Disappointed. 1 Reply @googbert 3 weeks ago Not enough time spent on seed- vegetable - processed oils. Stop them and notice how you feel. Reply @KayFlowidity 8 months ago 3:45 Mito-Night Club Reply @christinijohnson7790 7 months ago Why does this Dr. G, get so complicated in his explanations. I guess he doesn’t know that he’s talking to the public and not to other doctors. 1 Reply @beaubolinger1521 8 months ago I do not enjoy LISTENING to Gundry 3 Reply @user-xf6qf7pm7w 8 months ago Muscle cells do require insulin to take up glucose. Many nerve cells in the brain do not. Reply @robertarmstrong3024 1 month ago I almost turned to a different channel when he mentioned Gundry would be one if the guests. I only continued listening because I do know about the oxidative phosphorylation process in the mitochondria, so he won't be able to hustle me with his cute little analogies. Reply @1rocknroy 11 months ago Mi to CHON dri a ! 1 Reply @ajwilliams6516 2 months ago Gundry?! No! Dr Lustig is good. You want to know about mitochondria, listen to Dr. Ben Bickman. 3 Reply @aminreviews2311 9 months ago Muscle cells do require insulin for glucose uptake. 1 Reply @avoiceforthevoiceless2068 2 months ago Ugh, not Gundry, the sell-out guy who's showing up in every ad? Thank God we wised up and sold his books! What a mistake that was... No thanks! 1 Reply @deborahd.7281 9 months ago Some people believe that some paternal mitochondrial DNA survives into the generation, check out the Wikipedia article Paternal mtDNA transmission. Reply @jessoakley3746 9 months ago Although we may inherit mitochondrial DNA from our mother, it’s not that simple. MANY other DNA have influences on mitochondrial function. Those are from BOTH parents. Any mito specialist worth his/her salt knows this fact. 2 Reply @anitaparker9831 2 months ago Lost trust with Gundry being part of this. He intends to mislead. 2 Reply @alcoholfree6381 9 months ago NO TO GUNDRY!! Lustig is 100 times better. I turned off when this fake doctor came on. Didn’t he make enough money as a heart surgeon. What’s he doing high priced supplements with horrible reviews. 2 Reply @cgm1786 9 months ago Study Intelligent Design. Reply @idontcare4490 5 months ago Only person I cared about was Lustig Reply @mjrotondi5086 5 months ago Stop bashing and start listening . 1 Reply @janeh5949 5 months ago Meat is dead. Meat makes me sick. 1 Reply @blackswanrising2024 5 months ago spermidine is found in high levels in the sperm, try semen retention to accelerate autophagy and regeneration Reply @RobustArid379 6 months ago Eat more pizza to help mitochondria! Reply @sustainablelife1st 9 months ago gundry ruins your credibility. 6 Reply @Alice-oe4kd 10 months ago What was the good Lord smoking that day! Reply @pennycoyote3855 10 months ago ... Reply @onmybike8204 9 months ago The saund is so bad l can not anderstand Reply @jbyrd655 3 months ago Useless. 1 Reply @coltoncardinal313 7 months ago gundry sucks 1 Reply @albusai 10 months ago So go keto and intermittent fasting Reply