Most Longevity Experts Don't Tell You This About Aging | 56 - Longevity ...

Most Longevity Experts Don't Tell You This About Aging | 56 - Longevity Science #8 The Optispan Podcast with Matt Kaeberlein 8.82K subscribers Subscribed 187 Share Download Thanks Clip 3,676 views Aug 8, 2024 The Optispan Podcast with Matt Kaeberlein Subscribe to our channel: / @optispan Related episodes: Biological Age & what it REALLY means: • Biological Age & what it REALLY means... The Surprising Way Body Size Relates to Lifespan: • The Surprising Way Body Size Relates ... The Benefits of Protein Restriction, How Protein Affects Hormones & FGF21: • The Benefits of Protein Restriction, ... An introduction to the study of RAPAMYCIN: • An introduction to the study of RAPAM... Depending on how you look at them, aging genes are genes whose expression changes in a predictable with age or genes that influence an organism's lifespan by affecting various biological processes associated with aging. Research on aging genes not only deepens our understanding of the biological aging process, but also opens up potential avenues for developing therapies aimed at extending healthy human lifespan. By targeting these genes, scientists hope to delay the onset of age-related diseases such as Alzheimer's disease, cardiovascular disease, and cancer, ultimately promoting a longer and healthier life. In this episode, Matt discusses several ways we can identify and categorize aging genes. He talks about how genes can serve as predictive signatures of chronological or biological age, potential conserved genetic regulators of longevity, and how unbiased genetic screens can still be biased. He also provides his unique perspective on aging genes in humans and the potential to optimize longevity through genetic modulation. 0:00 Introduction 1:05 Definition 1 of an aging gene 2:23 Definition 2 of an aging gene 2:58 Genes as biomarkers of aging, biological age clocks 7:07 Nuances of definition 2 9:25 What we should be focusing on 10:59 The daf-2 gene and lifespan 12:41 The sir2 gene and lifespan 13:31 FGF21 and lifespan 14:28 Growth hormone mutants and lifespan 15:42 FOXO3a and longevity in humans 17:10 APOE genes and longevity in humans 18:06 Things to keep in mind when talking about aging genes 22:35 Matt blows your mind 31:03 Wrapping up Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: / optispanpodcast Twitter: / optispan Twitter: / mkaeberlein Linkedin: / optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful! Chapters View all Explore the podcast 64 episodes The Optispan Podcast with Matt Kaeberlein The Optispan Podcast with Matt Kaeberlein Podcasts Transcript Follow along using the transcript. Show transcript The Optispan Podcast with Matt Kaeberlein 8.82K subscribers Videos About 23:59 Biological Age & what it REALLY means | 9 - Longevity Science #3 by The Optispan Podcast with Matt Kaeberlein 48:21 The Benefits of Protein Restriction, How Protein Affects Hormones & FGF21 | 52 - Cristal Hill by The Optispan Podcast with Matt Kaeberlein 15 Comments rongmaw lin Add a comment... @60-Is-The-New-30 1 day ago (edited) BRILLIANT;, especially the ending section and how you dissected the science. Reply @erdemy2702 1 day ago This is an actionable video for scientists and policy makers. Something should be done. Reply @szghasem 1 day ago Has anyone tried under expressing mTOR, IGF1, P66Shc, RAS and over expressing FOXO3, SIRT1, AMPK and Nrf2 simultaneously. does that make sense? 2 Reply @AlisonHill-v3z 4 hours ago Interesting food for thought! It seems like more and more pro-aging genes are characterized as antagonistic pleiotropy--so it makes sense, in these cases, that loss of function would be associated with pro-longevity. Would love to see you talk a little more about the evolutionary theories of aging. Also, when does biological aging begin? It must be after natural selection no longer cares about us. Thank you so much for these lectures. I am very stimulated and engage by this material! Reply @fmfm9846 1 day ago Wonderful presentation, thank you for all that you share Reply The Optispan Podcast with Matt Kaeberlein · 1 reply @michelsamson3689 1 day ago Thanks Matt as always extremely interesting I never did get the answer about your Bonsai who takes care of it (I am into Bonsai myself) 1 Reply The Optispan Podcast with Matt Kaeberlein · 1 reply @wpmitra7251 8 hours ago Hello doc. If I find a way to preserve my DNA, zero loss. 10 years from now, same as now. What would be the effect on aging? Reply @bartb1014 21 hours ago How old are you sir? I can’t tell if you’re healthy or not 1 Reply @captainremington 2 days ago Then is it possible that we can assume early menopause (under the age of 45) is a rehearsal of decreased lifespan and more prone to chronic diseases at early ages? Reply @willkat64 1 day ago You’re barking on the wrong tree, Matt. Expression of longevity and aging genes is modulated by the epigenome – your so-called gene thermostat. Deciphering the role of the epigenome and environment in modulating gene expression as it relates to evolution is the key to understanding why we age and develop age-related chronic diseases. 6 Reply @jozefwoo8079 1 day ago You keep spamming that content! Reply