Does Red Meat Accelerate Aging, with David Sinclair CarnivoreMD

Does Red Meat Accelerate Aging, with David Sinclair PhD - UPDATE and REPOST CarnivoreMD 57,147 views Jan 18, 2022 David Andrew Sinclair, PhD is an Australian biologist and professor of genetics. He is also a co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, and is known for his research on aging with a focus on epigenetics. Time Stamps: 0:29:37 Podcast begins with David Sinclair 0:30:45 Is when we eat more important than what we eat? 0:32:55 What is the connection between time restrictive eating and longevity? 0:38:04 What causes us to age? 0:39:56 Epigenetic change. 0:47:13 What causes DNA breaks? 0:49:38 What plant foods create DNA breaks? 0:51:23 PARP enzymes 0:54:56 Where does NAD come from? How do we make it? What enzymes use it? 0:59:00 NAD recycling pathway. 1:06:23 Sirtuins. 1:18:24 What are the other longevity genes? (AMP kinase and mTOR) How are they connected to sirtuins? 1:26:00 Does being in a ketogenic state increase NAD? 1:34:40 Xenohormesis and plant molecules. 1:40:00 Resveratrol trials. 1:46:05 mTOR. 1:51:35 David’s thoughts on animal protein. 1:58:13 Meat consumption in relation to the environment and regenerative agriculture. 2:05:38 Where to find David Sinclair. Sponsors: Heart & Soil: www.heartandsoil.co Animal-Based Gathering: https://www.animalbasedgathering.com/ Key moments View all 439 Comments rongmaw lin Add a comment... Allen Brost Allen Brost 10 months ago (edited) I like how Shawn Baker frames this. He says that we can't prove a carnivore diet (or lack of a carnivore diet) will increase your lifespan, but he says that they can guarantee taking you from a sick miserable state to a healthy state and living a better life today. What other evidence do you need? 233 Reply 21 replies Carol Geiler - Evidential & Spiritual Medium Carol Geiler - Evidential & Spiritual Medium 10 months ago I COMPLETELY agree with you. I used to be a vegan and did all the things you were supposed to do and I just got sicker and sicker. I went carnivore and gained my life back. I could barely walk across the floor and now I am vibrant and can cycle 80 - 100 miles a week. What life is a sick life? It's no life and like you, I wouldn't trade it for anything! I also agree that long-term keto is not the best. I find I thrive and have better athletic performance with MINIMAL carbs. I am highly oxalate sensitive so have learned what few carbs I can add for variety. I also have to watch my protein intake. Too much causes some issues for me as well. It's all about knowing ourselves. Thank you Paul for being willing to shift, evolve, grow and admit it. We can't be so rigid that we don't expand and do what's best. Go meat! :) 100 Reply 21 replies ZuluAlphaCharlie ZuluAlphaCharlie 10 months ago Dr Radical! I've read your books, watched your vids and changed my families lives. You aren't the only doc I watch, but you are among the top. I put my cat and dogs on raw meat and organ diet and have extended their health span, as well. 17yr old cat that went from frail to formidable in a short time. 🥩💪🤙 34 Reply 3 replies Tough Love Papi Tough Love Papi 10 months ago Literally laughed when I saw this. Couldn’t have been more perfectly timed. I thought I’d look into David as I keep seeming him everywhere, and I felt like he was just pushing another Steven Gundry perspective and I was like…..how can this guy be the worlds leading longevity specialist when there’s so much of your work which stands in the face of it. Thank you for doing this, Paul. 41 Reply 4 replies AliciasSkinSecrets AliciasSkinSecrets 5 months ago I love that you don’t mind debating other people and putting it out there for everyone to hear I think it’s really great quality. I love your work and all the information you share with us. You have really good energy and I enjoy listening to you. 2 Reply mary nguyen mary nguyen 10 months ago (edited) My husband just contracted covid, he called his friend who is an old Chinese woman. Guess what she advises him " eat lots of meat ! ", great to hear that wisdom still prevails! 47 Reply 3 replies Christian Zoli Christian Zoli 2 weeks ago Good conversation. For once, it's nice to see people coming from different direction being able to negatiate their views and learn from each other. Kudos. 1 Reply GamingFreekish GamingFreekish 10 months ago (edited) I have watched many of Sinclair's videos. I think he is spot on with the mTOR, sirtuins, fasting, ect. data. However, it appears he is missing a few links in the chain and he often is spins epidemiological plant-based studies to fit his narrative. One example is his support for NAD, but then failure to notice that the NAD cycle is fuled by B3, which is almost exclusively found in animal foods, especially liver. (it is found in peanut butter too, but likely locked up in plant defense chemicals). I also like how you highlight that insulin spikes mTOR more than leucine. No one talks about that! Thank you Paul for sticking to the science, avoiding dogma, and following the logic! I can't believe you had him on, but it is yet another example of how open minded you are! 34 Reply 2 replies Naked Truth by Dr. Melanie Naked Truth by Dr. Melanie 10 months ago I had to have a root canal last year and considering your bone matrix and other formulas for myself and my patients. Great work Dr. Saladino! 16 Reply Oscar SH Oscar SH 2 months ago David Sinclair learned some stuff from this. Amazing, I love these in-depth conversations. 1 Reply The Larger Vision of Life The Larger Vision of Life 10 months ago (edited) Let Food be thy medicine and Medicine be thy food- needs more nuance for these times. A whole new approach to what exactly is food for daily nourishment and what is medicine for short term use. Great videos and ideas as always, Paul! Thanks for the work you are doing to revolutionize our understanding of these topics 8 Reply sghazi sghazi 2 weeks ago Hey Paul, i hope you get to read this comment and may be quickly respond in a short video or here in comment section. Before i discovered you channel i used to listen to all these doctors like David Sinclair, Stephen Gundry and others mostly keto advocates. Since i found your products and educational content along with it i decided to change my diet that i was following for about 7-8 years. I stopped taking leafy greens and mostly all the raw veggies and almost stopped taking resveretrol, Quertcetin and Berberine. Those were my main hormetic stressors. I still used the fermented vegetables. Paul when you say these things are medicines not food and should not be taken long term made sense. As i play sports multiple times a week I started with supplement immuno milk. i also started eating sweeter fruits like pineapple, papaya and mango along with honey. I always stayed away from sweet stuff cause i was told that viruses and bacteria feeds off from sugar in the body. I was very excited to see the result of my new diet but unfortunately i got caught with a bad viral Flu and got very weak. I must mention i didn't get affected by any virus including covid for past 7-8 years. In this situation i am confused about by diet plan. What is the carnivore code to fend against these viral flu. Now i am thinking of cutting back on sugars and bring back some of the hormetic stressors. I am getting a feeling that for urban centres where these viral flu is vicious kids getting sick almost every next week its a good strategy keep some low on sugars and have some hormetic stressors in every day life. I would love to get a feedback from Paul and with anyone who has similar experience Reply dill pick dill pick 10 months ago Fantastic my friend. It's always impressive how you seem to push these experts a little bit out of their comfort zone in their world. Keep pushing the envelope 15 Reply Abtin Abtin 10 months ago I appreciate your videos. I graduated with honors in biochemistry and electrochemistry and treat your videos as a continuation of my education 10 Reply Peter Cyr Peter Cyr 10 months ago (edited) I am my own blue zone. I am an insulin sensitive, fat adapted fat burner producing ketones. My liver makes all the glucose I need. Calorie restriction just comes naturally. I do one meal a day and extended multiday fasting every 5 or 6 weeks. 19 Reply 1 reply Fernando Almaguer Fernando Almaguer 10 months ago (edited) The big take away. That these gentlmen can have different perspectives and similar POVs and just learn from each other. Harmoniously... let us continue this in 2022 and beyond 18 Reply Gaurav Gaurav 6 months ago I follow you both! Best conversation I have come across in a long time!! Fasting and Mixing it up are the key takeaways!! Thanks Paul and David 1 Reply Ceci Palacios Ceci Palacios 10 months ago Listened the second time and enjoyed it even more. In my humble opinion, This is amongst the best conversations that David Sinclair has participated. I am a fan of Paul Saladino’s conversations and Heart and Soul products are excellent; definitely ordering Bone Matrix. Very Well researched and formulated products! 4 Reply 1 reply Lisa Taylor Lisa Taylor 10 months ago Loving this talk it’s great to hear these like minded researchers. I don’t think MD’s care as much about patients in my experience. My goodness I went to a gastroenterologist recently and wasn’t even palpated on the table. I sat across from doctor and his computer and given a prescription refill again… 3 Reply bhaskarbharath bhaskarbharath 10 months ago (edited) There are Societies that had longer life spans on Vegetarian ( not Vegan) diets like the Jains in India and there should definitely have been some that did the same on meat based diets. Sinclair is talking about how the amino acid sensing mTOR when kept active at higher number of times would be detrimental for longevity due to epigenetic damage. He is not biased and not talking about cutting meat completely. He is just saying you shouldn't be eating too much of it. It might shackle some beliefs particularly in those where their life has got significantly better with Carnivore diet. But we ought to keep an open mind to science. I am looking at many comments saying 'oh he is a researcher he doesn't know anything about diet'. Do you think the so called Dietitians, Nutritionists and most Doctors know anything about diet and nutrition for that matter!? Atleast this man knows the hormonal response and how your epigenome changes based on what you eat which is far more than anyone can ever know. Just be humble in your approach to learn guys. Please!! Keep being a Carnivore if it works for you and believe in it. But respect what this man has to say. 72 Reply 7 replies drew barefoot drew barefoot 10 months ago Love both of you guys. Thanks for putting this out Paul! 2 Reply Mickey Hoffman Mickey Hoffman 4 months ago This was one of the most beautiful, intelligent and knowledgeable videos/podcasts I have ever seen. Thank you Paul and David. Brilliant men. Much love 1 Reply J Ivan Escalante-Garcia J Ivan Escalante-Garcia 10 months ago Nice exchange of ideas. Sinclair is a great researcher and open minded scientist. I learned a lot this time; some parts are just too much science for an engineer like me. 1 Reply Response Digital Media Response Digital Media 10 months ago Thanks for the update Dr! Even at the young age of 60 something I have friends (that I’ve tried to convert to carnivore) that have to limit their activities and they just attribute it to getting older. I feel bad when I picture them in their 70s and 80s… I intend on taking care of myself till the very end, with no medications, walkers or diapers! Side note; so do you wear contacts now? Or has this lifestyle improved your eyesight? 16 Reply 2 replies Tammy B Tammy B 10 months ago (edited) This is what I was looking for! After watching the first 2 episodes of Lifespan and shaking my head "Noooooo" through out I was wanting a rebuttal. David Sinclair was totally spanked here and a few things came to mind: one is I feel like Sinclair might be biased toward his research which is understandable but not scientific, the other is that maybe he is a part of the 'opposing ' agenda. Third Yes, you CAN do something about epigenetics. Lastly, I think if you are carnivore you're not going to eat a lot/often and IF comes naturally which negates the mTor/AMPK cycle. Personally, I was a vegetarian for 10 years and became so very sick. My TCM practitioner said I was totally depleted and I needed to eat meat, after some debate I started with bone broth and it was like elixir of the gods and I've never looked back 👍 11 Reply Ziggy Z Ziggy Z 4 months ago Awesome podcast. 2 hours- crazy! So much information 1 Reply D Man D Man 10 months ago I was waiting for this one. Really interested in Paul pressing David on the health benefits of red meat! Let’s go! 4 Reply doug doug 10 months ago Been listening to David Sinclare and other sources and examples of high veg promoting longevity. Looking forward to hear Paul’s comments in regard to this Reply 7gardenias 7gardenias 10 months ago I can't absorb all the details and I spend too much time in front of the computer, but I love your open mind. I'm still trying to figure out what to eat and I'll see what the cardiologist says when he sees my cholesterol has gone up from eating lots of red meat (and a few organs). Dr. Paul would you consider interviewing someone like Dr. John Douillard who promotes Ayurveda and wrote that book "Eat Wheat"? Thanks for all you put out. Probably mind set is more important than anything we put in mouth actually, within reason. 2 Reply 2 replies mark marcinik mark marcinik 10 months ago Another issue is that food intake needs to me in sync with physical activity. Someone that sits and reads all day is going to require a different diet than someone that physically labors all day . 6 Reply J North J North 10 months ago Regarding how Sinclair mentioned the study in mice with BCAAs, this probably wouldn't have occurred if using EAAs. There are many other studies that had already shown high BCAAs as bad. So it is specific to the type of aminos - EAAs would have likely shown the opposite to be beneficial as other studies have already shown. Reply Jim Hebert 'Abear' Jim Hebert 'Abear' 10 months ago I decided awhile back that I would ignore Sinclair on diet in favor of Saladino. but also listen to and take seriously Sinclair's healthspan and lifespan hacks. 43 Reply 7 replies DoubleA923 DoubleA923 10 months ago I'm leaning more towards Dr. Sinclair's research. But I do like Dr. Saladino's challenging view. I just wish they could both give more time to talk w/no interruptions & to show or talk about 1 study, that study being themselves. We can talk bout rats or other animals but I see these 2 doctors are Living what they preach! This is the perfect research study to show off your own work. So Sinclair vs Saladino on reviewing their inner age thru a series of different tests. That'll be more convincing. 9 Reply Luke Anderson Luke Anderson 10 months ago Paul, will you send Dr. Sinclair the studies prior to your next podcast with him? To give him time to review before coming on. You the man. 5 Reply Sonya M Sonya M 10 months ago Such a good debate. Really enjoyed it thanks!! Reply Klaas van Kleef Klaas van Kleef 10 months ago Hi man, just saw your appearance at the 'doctors'. You were the only sane person in that room. Good job! 10 Reply 1 reply Barsimea Barsimea 10 months ago Thank you! I learned a lot from you! I'm very thankful of having found you! 1 Reply Peter Cyr Peter Cyr 10 months ago When you talk to Sinclair, remind him that true herbavores like cows and gorillas use fat as a primary fuel. It is made in their large complex digestive systems from fiber. We cant do that. 15 Reply Jason Hansen Jason Hansen 10 months ago Anecdotally I can say since starting a life style in an animal base diet 2 years ago, I have gotten younger? What? Thee only way to describe it. I am stronger without doing any strength training, my hair has begun darkening and getting thicker. I still have thin hair but there was a time I was nearly bald and was very grey. Darker hair, more hair? I was taking 8 different medications 2 for high blood pressure, a statin, 3 for type 2 diabetes, 1 for acid reflux/gourd and 1 for depression. I take no more medication and have reversed type 2 diabetes. No more depression, no more chest pain, no more high blood pressure. I can go on, so many cool things that are still happening. So does this prolong life? I would be dead or in a care facility before I made it to 52. I feel better now than in my 20's. Still healing, 20 plus years of abuse to myself some due to ignorance and some due to poor choices it does not completely heal over night. Red meat? Was beaten into my head, bad for diabetes, bad for health. Okay to the people that think that, red meat saved my life. Paul is one of several Doctors who have contributed to me saving my life, thanks! My wife uses bone matrix she started a month ago, her joint pain, mostly her knees is gone! I mean it is gone! I purchased some for me today get it tomorrow, I will have mine and she has hers! 15 Reply 3 replies Katarina Morvai Katarina Morvai 10 months ago Interesting to watch the energy level of these two gentlemen. Very different. 2 Reply 1 reply Jeremiah Charles Jeremiah Charles 9 months ago I wonder if the same alternate day modulation would be beneficial for taking Tahitian Noni. The compound in Noni, grapes and other medicinal stressed plants are iridoids. Resveratrol is an iridoid. Tahitian Noni has the highest iridoid levels and has been revered as a plant medicine for thousands of years. Reply Ceci Palacios Ceci Palacios 10 months ago That will be awesome if Andrew and you interview each other! David Sinclair is evolving by the month seems like....but I love the skin products he has helped developed.. 1 Reply Benjamin Britt Benjamin Britt 10 months ago Such an educated and tbought provoking discussion 3 Reply stevoblevo stevoblevo 10 months ago What mechanism would you point to in order to support the concept that the body stops absorbing iron after a healthy level? 1 Reply Lauren Lauren 10 months ago OH MAH GAH! I was seriously about to ask you about some of David Sinclair's claims as part of your AMA. Excited to listen to this. 2 Reply Math Lind Math Lind 8 months ago What a wonderful and fruitful discussion. Reply MonopolyJ1 MonopolyJ1 10 months ago You have such great energy ! Thank you ! Reply Nano González Nano González 10 months ago Hello Paul good morning, greetings from Chile South America. it is a pleasure to learn with you but most of your videos do not have subtitles. It would be a great help to continue learning. 4 Reply 2 replies Sanguine Sanguine 10 months ago Discovered I'm a single carrier of a hemochromatosis gene a few years ago while doing a research study. Luckily my iron level is just outside the normal range atm, so is easy to manage with monthly phlebotomy. Reply Hunters & Collectors Hunters & Collectors 10 months ago David Sinclair is a scientist and it would be interesting to find out who funds his lab and research. 15 Reply 3 replies TheAncientWonder TheAncientWonder 10 months ago Meat based diet is optimal and if you practice it you can indluge on some temptations and not stress about it Reply Art Art 9 months ago My 79 year young buddy just picked up his Tesla Plaid in Jacksonville. Full Self Driving will complete his peace about aging and his mind. Starches and whole grains make my vision blurry and make my skin break out in nasty rashes. Consider the diet of an Eagle and the miles of clarity it has when searching for animals to eat. Greens constipate my wife and I. I study our bowel movements almost daily. 90% lean quality meat can constipate us as well. Great interview. Lots of notes gentlemen. Radical💩! Reply Justin Jozokos Justin Jozokos 10 months ago Funny that immediately after saying he envies physicists, he says that he has the strong gut feeling that aging comes with the loss of information. It's funny because the second law of thermodynamics, one of the most fundamental insights in the whole of physics, can be phrased in terms of information, and it's that information is lost with the passage of time; that irreversible processes are those in which information is somehow destroyed. It would make physical sense for aging to come with an associated loss of information like he suggests I'm a physicist, and while many people like to say that entropy is a measure of disorder, this is really inexact use of language. Much more precisely, entropy is information that no one has access to about any given system. The statement that entropy increases as a function of time is completely equivalent to the statement that the total amount of information in the universe that no one has access to grows with the passage of time. In other words, information is lost over time 4 Reply 1 reply Cav Cav 9 months ago This was a very interesting video, I liked hearing both perspectives. I was a little disappointed to see the host, Paul Saladino, sort of knowledge bombing David Sinclair. In other words it was a bit of a one sided conversation where Saladino brought up topics, explained them, and asked Sinclair to confirm them. If Sinclair does not come back on the podcast it may be because of this dynamic. I would love to see these two have another conversation though because with two starkly opposing views there will be something to learn. Side note. I find it funny that the host has ”salad” in his last name. Reply Elaine S Elaine S 10 months ago I follow both you and Andrew. I am still hesitant to believe most of what DS shares. (Could most of it be tainted and for his own profit?) is what I keep wondering. 12 Reply 3 replies Unknown User Unknown User 10 months ago People have used epigenetics to reverse biological age. the diet had a lot of eggs, liver, keto leaning style macro's it did have a greens powder supplement but the antioxidant in greens powder and teas can be found in animals that eat wild plants and herbs. Reply 1 reply Cammi Eklund Cammi Eklund 10 months ago What do you think about Frank Tufano having iron overload after 8 years of carnivore? He did eat lots of liver though, that might have contributed to it?🤔 4 Reply Toby Dude Toby Dude 10 months ago Brilliant interview! Reply Jakub Jakub 4 months ago We need a new conversation with Mr. Sinclair, please Reply andrew wilson andrew wilson 10 months ago so David learned that metformin in mice needed to be given in day-on-day off cycles otherwise there was a negative effect and later talks about metformin downregulating Igf1. it surprises me that he still seems cautious and almost fearful of the idea of using igf1. I really feel he has a bias against meat and this was clear when he seem dubious on Pauls reports of EPA data I wish all these people with the ability would sheer their blood work as paul has 1 Reply Maria Daniels Maria Daniels 10 months ago So all of this is such new thinking for my generation, my son in law is the one that got me listening to this, my question …. Is it to late at our age to turn the tide for my husband and I age 62 and 65, my husband has always tried to eat “healthy” simply because he wanted to be around to raise our large family, but has noticed a decreased amount of strength and energy. He is African American, has high blood pressure ( he was able to get off of high blood pressure medication for a while when he went vegetarian for two months) but lost too much weight and strength. But he hates taking blood pressure medication that’s the only medication he takes. He does have a lot of joint pain, he is a hard worker truck driver. But has been showing signs of decreased kidney function based on the creatinine levels in his blood and struggles with borderline diabetes, whatever those levels go up he does whatever he can to get them back down. I would love to see him get his vitality back. So is it too late for us? 2 Reply 7 replies Ronald Norman Ronald Norman 10 months ago (edited) You always nail it! Thank you! I was listening to David Sinclair yesterday and I got turned off and unsubscribed when he started pushing the vegan narrative and I felt that he wasn't giving the full perspective. You on the other hand, provide the full picture! 7 Reply 4 replies Louis Burns Louis Burns 10 months ago I wish the links to the studies mentioned were in the description. 1 Reply Integrated Performance Solutions Integrated Performance Solutions 10 months ago I don’t get it. David’s diet is so great that he needs to take a ton of supplements. For those of us who don’t have a salary from Harvard, how do you even afford to follow such a regimen? It sounds like he spends more on supplements than I spend on food. 11 Reply 5 replies Dylan Tracy Dylan Tracy 10 months ago I think Paul should dig into the research around plant intelligence. In my opinion this should be the best argument against saying that animals are sentient so therefore we should just eat plants cause they don’t think, feel, or make complex decisions which new research challenges Reply 1 reply Kylie McCarthy Kylie McCarthy 9 months ago Carnivore MD i am all over your pod casts and loving my new learnings from you. Just one thing in regards to this pod cast. Niacin- not nicotinamide, Niacin, increases the life span of mice by up to 20%! There is a book called Niacin the Real Truth... What do you think of this book Dr Paul? Reply 2 replies Jenna Hott Jenna Hott 10 months ago What about iron overload from growing up with the standard American diet? Everything was fortified with inorganic forms of iron and the body can only process so much of it each day so I’ve heard the body will store the excess in organs and tissues. 1 Reply 1 reply N of 1 N of 1 9 months ago I don't just want to keep the cell live, I want to reverse DNA damage. Does this mean MNM will help do this? Reply \m/etal GameDog \m/etal GameDog 10 months ago (edited) I don't know if Dr Sinclair is over 50, I think 54 years old, but here in Italy many people his age look like him by doing a Mediterranean diet and not doing a harmful diet like vegan and stuffing himself with supplements, I am almost a 47 years old and I look like a 30 year old but I do a paleo (saladino style) / carnivore cycle and intermittent fasting daily ...and I don't use supplements 4 Reply 1 reply Points HealthCoaching Points HealthCoaching 10 months ago Thank you for explaining time line Reply Jana Radonjic Jana Radonjic 10 months ago (edited) I also have a tone of respect for David and his work. But as a sensible human being, I can only feel that this man is so sad inside. I don't see the passion for life, energy nor liveliness in this speech, attitude, stance. You can feel that in the person, he looks deprived. And the way of eating he speaks about, I tried almost 20 years ago. And that doesn't work for women nor for any adult that wants to live fully and have a family. In my humble opinion, he suggests starvation. And that gentleman thrives on supplements. 7 Reply 2 replies christie anderson christie anderson 10 months ago Since I went carnivore my neck has tightened up. I look much better at 48. 1 Reply It’s a good day It’s a good day 10 months ago There are something i am not sure where i stand: Quran has mentioned some fruits and vegetables including Black seed (it can cure everything except death). How can it be that this Holy book had this information around 632 AD and the benefits. You are probably right, we should use this as medicine only. Someone who has endometriosis and continue figure out why the body makes extra estrogen and why there are scar tissues or cyst in the ovaries, i am increasing my meat consumption more and more to see if this is the answer for me to beat Endo. Reply Caroline Yunker Caroline Yunker 9 months ago There was a study that women who have a ferritin level over 200 has a higher risk of stroke. I think keeping ferritn to 100 is best. Reply C C 4 months ago Carnivore MD: LETS TALK MEAT David Sinclair: Mice that were fed only 2 hours A day.. Reply Jakub Jakub 10 months ago Mr Saladino, you are top man! Thank you. 1 Reply Sybil O'Brien Sybil O'Brien 10 months ago PLEASE make available in Canada!!! 2 Reply CK Etheridge CK Etheridge 10 months ago This is too good!!! Reply Optimize with Ivan Optimize with Ivan 9 months ago I love the sense of reason in this channel in the face of all the vegan propaganda gaining strength worldwide Reply Johnmichael Vega Johnmichael Vega 2 months ago David Sinclair has said he is helping the planet by not eating meat ! He said this in a talk he gave in 2019. 1 Reply FactsPirate FactsPirate 10 months ago Keep up the good fight mate. 1 Reply Garrett Berger Garrett Berger 10 months ago (edited) Loved the first 30 min preface paul! I agree 3 Reply electronikadze. electronikadze. 10 months ago (edited) How can we follow a low-carb diet (as gluten and starch are proven to be some of the strongest triggers of inflammation and disease) while avoiding meat and still getting enough high-quality protein? I guess once again, the only true answer (considering all points of view) is BALANCE. Something between Keto and Mediterranean diet would be optimal - not too much animal fat&protein (Keto) and not too much grains (Mediterranean). Everything else, sticks - lots of non-starchy veggies, some fruit, lots of nuts & seed, legumes, fish and good oils (avocados, olive oil, flax, ghee), low GI grains (buckwheat, quinoa, barley, wild rice, einkorn), and some (preferably fermented) dairy. Drink - water, some coffee and tea, and a glass of red wine. 4 Reply 1 reply cyrus lashkari cyrus lashkari 2 months ago I don't think Sinclair thought he was walking in on a debate. He probably thought he was going to be admired and to go into his studies more. Maybe he might not show up again because of this Reply Mr. S Mr. S 10 months ago Why does everybody say David Sinclair looks young? He looks his age 11 Reply 2 replies Noah Myers Noah Myers 10 months ago To be fair legumes, certain vegetables, and a number of fruits like avocado, mango, butternut squash provide a ton of folate 2 Reply 1 reply Juan Won One Yuan Juan Won One Yuan 10 months ago niacinamide becomes NAD+ and then activates sirtuins. it only inhibits it for a few hours, the total overall activation is increased from NAM. NR decompose thru digestion so its probably better to just take NAM. Reply 1 reply Brandon Anderson Brandon Anderson 3 months ago WELL DOC, U ARE TAKING THEM ALL ON!!! Reply MassageTeam MassageTeam 10 months ago (edited) If calorie restriction "always leads to extended lifespans" then why is un/under treated anorexia one of the deadliest psychiatric illnesses? We're talking about slow suicide that leads to an average age of death of 56 in females - a whopping 25 years earlier than the general public. And, the word average signals that many in the dataset are dying far younger. Average age of onset is 15 in females (meaning the seeds are planted even younger). And before someone jumps in and says "it's all about balance" I would counter that due to psychologic and societal factors, ANY degree of calorie restriction is probably inappropriate for the vast majority of females in their pre-menopausal years under age 50. That, with obvious exceptions for medically supervised (not online, peer "Ana" sites) of very specific conditions. Same basic statements for male anorexics and "big-orexics" although the statistics are not as striking. 3 Reply 1 reply T T 10 months ago Re resveratrol --- it can't be right that red wine would be bad for us. It is the great gift of Bacchus.🙂🤭 Reply GeoHiker GeoHiker 10 months ago I feel better than ever on Beef organs! 1 Reply 54M views 54M views 10 months ago Good morning!!!! Paul and David together? Jesus, that's a good day 3 Reply seekeroftruth06 seekeroftruth06 10 months ago Never felt better since eating mainly meat 3 Reply Shtimpok Shtimpok 10 months ago I would pay $100 to see a one on one with Dr. Paul Saladino and Dr. Nun Amen-Ra 1 Reply Claudia S Claudia S 10 months ago Agreed! 1 Reply Peter Cyr Peter Cyr 10 months ago (edited) It amuses me Dr Sinclair predicts a great increase in longevity completely ignoring the diet driven worldwide epidemic in diabetes. Everything he says is moot in light of this. 9 Reply 3 replies Alejandro Rios Alejandro Rios 10 months ago Nice :) I think this is a must see! 1 Reply Shinji K Shinji K 10 months ago I agree. I'd rather be strong and live longer. 2 Reply bob bob 10 months ago Dr Paul; you are one smart dude! Reply Michael Schmidt Michael Schmidt 10 months ago Where are the links to the cited studies. I miss them in this one :( 1 Reply Laurence Lefevre Laurence Lefevre 3 months ago All about the carnosine 😁🔥👌 Reply stevoblevo stevoblevo 10 months ago what does heme iron from organ meats all have in common? Copper. quite possible both Sinclair and Saladino are "right" in their perspectives: Iron overload is a serious thing (Sinclair) and "excess" iron isn't a big deal (Saladino) with the deciding factor being ferroxidase function and metabolic health provided by Ceruloplasmin. Copper. the difference in opinion might also be explained by different goals or definitions of health. Many don't distinguish between vitality in terms of virility/fertility or vitality in terms of lifespan/longevity and there may indeed be a huge difference in which lifestyles are most effective toward either aim. It may be a trade-off the body has to make. If Saladino were 55yo instead of 30s/40s (Sorry Paul, not sure how old you are. lookin' good tho!) he may have an entirely different perspective, as Ray Cronise has an entirely different perspective. [check out Cronise on Dr. Rhonda Patrick's podcast from years ago] 1 Reply 1 reply Joey Georgiou Joey Georgiou 10 months ago I once watched a video of Sinclair talking about nutrition regarding longevity and he said that one day he went out and had fried chicken and he felt horrible.. He lost all respect from me right there and then. Chicken (worst meat to have), fried (in vegetable oil), probably with chips and a coke. That's how he thought he tried carnivore/animal based and then didn't like the idea. I couldn't believe it, for a professor of biology that advocates for health and longevity of humans, he compared animal foods with plant foods this way.. I don't know if it was lack of knowledge, or profits behind it but no matter what, people are actually listening to him and he 's got some pull. 16 Reply 11 replies Adria Peet Adria Peet 10 months ago I'm obsessed with sourkraut and pickles but dont care about any other veggies. How bad are those?? 2 Reply 1 reply er b er b 10 months ago I eat peeled millet and i dont have problems(my autoimune is fine) with it like with the white rice(i have headaches) and i want to ask is there harmful compounds like phytic acid or oxalates or other things in it? Reply 1 reply jonfragments jonfragments 9 months ago (edited) Sinclair made a profound statement at 1:55:01 , he said that is what mTor is designed for. This is the opposite of what evolutionist teach. The evolutionist claims that things just evolved. But they did not. All things were designed. This truthful statement by Sinclair speaks to his character. Reply Key West Fan Key West Fan 10 months ago We all know if you get hit by cosmic rays you turn into a super strong orange rock creature 1 Reply ELIZABETH ARNDELL ELIZABETH ARNDELL 10 months ago Dr Sinclair is now saying that “iron” causes ageing. Reply GeoHiker GeoHiker 10 months ago Lookin' good in glasses. So inspired by your enthusiasm, Paul! 1 Reply frenchis19 frenchis19 4 months ago Youre the Tesla of nutrient!! Reply Mathew Mathew 10 months ago it really didn't seem that his stance on not eating red meat is from anything but an ethical point of view from family pressure and his own ethical values, which is completely fine in my point of view. 4 Reply 4 replies Robert Lawrence Robert Lawrence 10 months ago Tremendous :) Reply Special K Special K 10 months ago You’re much more handsome now Dr Paul. Go Carnivore! 7 Reply LeeAnn Morgan LeeAnn Morgan 10 months ago "Faustian Bargain": Great metaphor! 2 Reply Mark Ziegler Mark Ziegler 10 months ago News alert. Hand gestures can cause DNA breaks. Reply Sir Great Sir Great 5 months ago Great conversation that is a bit dated now but I would love to hear what David Sinclair would think today. I think he was off on the plant basted ideology, not that I only eat meat, I eat both but saying plant>meat is a broken fallacy. 1 Reply Fun Times Fun Times 10 months ago This guy sounds pretty convincing but can someone answer me this, if what he's saying is true why aren't there many more scientists out there advocating for a mostly meat diet? He can't be smarter than everyone else can he? 2 Reply 13 replies T T 10 months ago Another dietary aptonym (Dave Chapman's coinage) -- Raphael di Carbo. The angel of carbs? Or the ironic opposite, like Saladino and Berry? 🤔🤔🤔 Reply just me just me 10 months ago David Sinclair looks like Paul did when he was vegan & malnourished. All Paul has to do is show his before (while vegan) and after (animal-based) pics to end any debate. 7 Reply 1 reply anyuisbjoern anyuisbjoern 10 months ago (edited) 1:58:00 environment and meat: i have to look up it again and i am not pro or contra. but from what i heard and know for cattle its especially methane which is the problem. I just heard it from friends who are good with this calculation stuff and some of them used to calculate such stuff. also calculating such carbon footprints or life cycle analysis is very complicated. if you just refer to regenerative agriculture…. if you not transport the meat through the whole country or abroad, it’s probably much more ecological than normal meat. Cause the soil is binding CO2 and you plant flower and biodiversity for insects or other beings. Good soil also help erosion. For Europe the most ecological- or meat-protein might be wild boar, cause it’s has no predator and is damaging the forest in to large scales. But that meat in general is very ecological I haven’t heard. Probably in small scale organic or permaculture-style farming, without much transportation but I doubt that it very ecological for the masses. Edit: It would be interesting if you could make a interview with a scientist on this topic and debate on this. And not someone who has your opinion, but rather someone who has the opinion you try argue against it. Reply K K 10 months ago (edited) True calorie restriction or Maintenance Calories via OMAD but with low Blood Glucose all day? Reply Philly3458 Philly3458 10 months ago (edited) You need to let your guest talk. Would like to see an update where you ask questions and let your guest answer and stop lecturing with your bias. David is the real deal. An accomplished researcher on the front lines of aging research. He clearly is being respectful to your point of view and only occasionally inserts real science. 14 Reply 3 replies Reed Pattenaude Reed Pattenaude 10 months ago Bro if Sinclair would get a life that would help 3 Reply 1 reply fiorenzeandrevittore fiorenzeandrevittore 10 months ago another guest Satchidananda Panda explores the genes, molecules and cells that keep the whole body on the same circadian clock Reply Ars Awesome Ars Awesome 10 months ago Pls talk about hair fall and hair thining problem cz im suffering thanks 1 Reply 2 replies Peter Shev Peter Shev 10 months ago tbh, Paul has aged a lot in just a few years 3 Reply 6 replies Albietz aesthetics Albietz aesthetics 10 months ago I miss this Paul. He was more evolutionarily honest and less snake oil salesman-E 3 Reply NOTREALLY HANKAARON NOTREALLY HANKAARON 10 months ago No. Red meat is proper human food. 😋 3 Reply doug doug 10 months ago You can’t say there is a net negative outcome from eating plants with the longest living, strongest and healthiest populations like the Hunza or Okinawans eat mostly plants. I want to eat for longevity and I can’t ignore these diets that are proven 1 Reply 3 replies The One Who Knocks The One Who Knocks 10 months ago if red meat is bad...im a goner 7 Reply Matthew Matthew 3 months ago I only recognized you by your voice. WOW!!! Reply JennyM JennyM 10 months ago I betcha any diet is human healthy as long as highly processed (not homemade bread— one researcher claimed homemade sourdough bread was a longevity food! ) foods and high sugar consumption is avoided. I’ve met vegans who live almost entirely on carbs—— pasta, white rice, etc, and actually eat very few green vegetables because they don’t actually like the green vegetables!😂. Obviously, there are healthy carnivores and healthy vegans, so no point in pushing one diet—- though I do wonder if a carnivore can maintain health for 95 years….. 1 Reply Jeff Deneen Jeff Deneen 10 months ago (edited) Meat...Medicine from the earth. Reply A P A P 10 months ago Meat is great, if your FADS gene is the right type. Match your diet with your genes. Longevity in a sickly starving state is not ideal. Your immune system will tank. You are just not going to be robust enough against the elements. Maintaining your proteostasis is more important than anything else. 2 Reply 1 reply Randoom Randoom 10 months ago My adult achne has gone since going animal based. My forehead is smooth! 2 Reply 3 replies James Herried James Herried 9 months ago One thing that we know for sure is that humans are not carnivores, by nature. No primates are carnivores. And that fact alone refutes Saladino's hypothesis that the carnivore diet is the ideal diet for all humans. 3 Reply 7 replies Adam A. Adam A. 10 months ago (edited) Where are the long term studies that show people eating a lot of meat live longer than the general population? Because the seventh day Adventists in Loma Linda are the longest living demographic in this country, and they are pesco-vegetarian, vegetarian, and vegan. I don't think red meat accelerates aging, but it is disease promoting, which can kill you before your time from heart disease, cancer, diabetes etc.... I never heard of studies saying beans promote heart disease, cancer, or diabetes. Vegetarians, and vegans don't tend to living longer because plants slow aging, they live longer because they don't get taken out prematurely by diseases as much. 2 Reply Ars Awesome Ars Awesome 10 months ago You are so real 1 Reply M W M W 10 months ago I love listening to Sinclair, but seriously he barely had a chance to speak. I would say that this wasn’t really an interview, but rather Saladino trying to impress the audience by randomly calling out various research results but without a clear message. overexcited and somewhat disorganized interview style not tailored to an audience. Fortunately, many more Sinclair interviews on other channels plus his own new podcast Lifespan. Still thanks for sharing but definitely room for improvement. 4 Reply Artkido Lee Artkido Lee 10 months ago I believe every thing in moderation 1 Reply Imran Suhail Imran Suhail 9 months ago (edited) vegans having low quality sperm sounds wrong. maybe its only strict vegans that dont use any dairy? Most of india is vegan+dairy and their birth rate is very high. I find it interesting that longevity and vitality is being considered the same thing but they might not. it might turn out that less vital and bad at reproduction people live longer. it would make evolutionary sense as well since if the animal is living longer it doesnt need to reproduce as often to keep the population up. im doing meat based diet recently and dropping fat easier than ever before and feel more healthy overall but is it good for long term is also my topic of interest. 1 Reply Better Humanz Better Humanz 10 months ago Typical Carinivore lol yeah your smarter than a scientist that has been studying this the last 20 years. I have been a full on Carnivore since birth..I eat meat (high quality) every other day and actually did the carnivore diet for 1 year eating meat everyday. and sometimes everyday...Yes you feel strong and satiated but is it really good for you?....I took blood tests before I went full Carnivore and 6months in and 1 year done. My iron and Ferritin levels were insane and far to high. My inflammation markers also increased. I have now done 1 full year with only eating once per day and I eat meat only once per week....mixing that with correct breathing and cold therapy I feel better than I did when I was 20 (currently 52), and my blood work is now on point...I want to be here for the long term for my family and not be selfish feeling like a million dollars everyday, when infact with the right balance and lifestyle you can feel a lot better than eating meat everyday.......maybe you need to do an actual experiment on yourself to understand your own body. 3 Reply REALTOR Carisa Jenner Message me! REALTOR Carisa Jenner Message me! 10 months ago Oh.. this should be good... #ancestralketolife 1 Reply Pungsvette Pungsvette 10 months ago Hello buddy, the difference between you and David is that he knows how to read studies and he does not have a bias, while you pick out single studies that backs your bias. I would recommend going vegan for you because it’s shown to decrease mortality and is much more sustainable than a carnivore diet. 3 Reply Shinji K Shinji K 10 months ago Paul live longer because he looks healthier than David. I follow David's research, but I don't like his diet. 3 Reply janybanani janybanani 10 months ago When do you start to ship international? Reply Nicole Hoffmann Nicole Hoffmann 10 months ago (edited) Me as an European wondering and laughing.i mean you teach nutrition from studies not from real life,ppl go either hard-core vegan smashing smoothies or carnivore.here in France,Greece,Italy,Germany we eat a diet in high quality food,we have a long tradition eating together, cooking together .and we ear meat and carbs together,lol and also loooooooots of vegetables.,potatoes,bread ,drinking wine and the majority,well especially the generation over 40 is pretty healthy.so I think you in the US never experienced traditional eating,cooking.....and that there is a lot more to health than obsessing about diet....you also live in Lala land sitting in Costa Rica,and promoting your diet.lets see if you had to feed a family of 9 and grow your own food .now I will enjoy my rhubarb cake with high oxalate which is a tradition here. 5 Reply 2 replies Celeste Schacht Celeste Schacht 10 months ago Now I'm sorry I bought NMN supplement. Should I throw it out? Reply 1 reply Jack G Jack G 10 months ago 💯 Reply Pespsi Jackson ● Pespsi Jackson ● 7 months ago meat takes 65 hours to digest Reply isaac brosinski isaac brosinski 10 months ago You looked kinda like a nerd back then, but now you look great! 😃 Reply LeeAnn Morgan LeeAnn Morgan 10 months ago Still listening! 1 Reply Samuel Samuel 10 months ago Complete sidenote, do you no longer wear glasses? Is there a reason? Reply peous paul peous paul 1 month ago What causes us to get age is not important.. what cause is get autoimmune diseases.. what causes society fall into infertility trap ?? Reply The Complaining Channel The Complaining Channel 10 months ago Not sure how I feel about this guy 8 Reply 2 replies ooGento ooGento 10 months ago I dont understand why everyone keep talking about fasting an entire day, not eating carbs and what not. Why can't eat everything in moderation. I eat pretty much daily everything exept sweets. I will have a piece of cake on weekends but then if im not gonna be hungry at night i will just have a steak ad some veggies but if i will be hungry, if i will have the need of carbs to complete my day, heck im gonna make myself some pasta, potatoes or rice. Nowadays people are seriosly overcomplicating things. We have all the information we need, we know eating fast food is not good we have every information we need. Reply K K 10 months ago Paul, PLEASE INVITE DR. GREGER as well!!! The fuckery is amazing with this one. https://www.youtube.com/watch?v=K8HkWPPKfsU 2 Reply Samuel Samuel 10 months ago Paul looking stoned AF 1 Reply mohamed eltahan mohamed eltahan 5 months ago How do you have good teeth doctor, how do you make them this white? Reply Pespsi Jackson ● Pespsi Jackson ● 7 months ago paul is totally a freak doctor Reply Brian Mahoney Brian Mahoney 10 months ago (edited) You went too hard on the Rona to have those types of dudes back on Reply Significant Other Significant Other 10 months ago Hmmm Leucine and resveratrol symbiosis, are we saying red wine with the my steak tonight? Reply Pano Pano 10 months ago Listen to grant Rutledge and Michael Rose on YouTube ancestry symposium for actual Science on aging and longevity 1 Reply J C J C 10 months ago How pathetic that his child influences his dietary choices. Makes me question his reasoning abilities. 4 Reply Luann Rouff Luann Rouff 8 months ago Longer doesn't interest me. Better is the ticket. That means meat. Today. Reply Noémie Delagarde Noémie Delagarde 10 months ago The blue balls ! hahahah 1 Reply Yano's Tropical Paradise Yano's Tropical Paradise 10 months ago Does Red Meat Accelerate Aging? simple answer is !no! it doesn't and never will. what can cause ageing? malnutrition, a vegan diet, an inflammatory diet such as a SADiet. and actual prolonged starvation. but ageing is not the same as a prolonged or shortened lifespan. i believe you can shorten your life by bad diets, but i don't believe you can lengthen it. let's assume everyone's lifespan is over 120 years, ad i actually believe it is, but people eating the wrong foods and doing unhealthy things damage their bodies and shorten this lifespan. 3 Reply 22 replies Eulalia Eulalia 7 months ago David Sinclair looks sick. 1 Reply Samantha Kiu Samantha Kiu 10 months ago then how come the most long lived population mainly eat vegetables and fruits and just a little meat? 1 Reply 8 replies Mark Johnston Mark Johnston 10 months ago More diet wars… the reality is the longest lived and healthiest people in the world eat a mostly plant-based diet. 2 Reply 3 replies Jeff Rey Jeff Rey 10 months ago Do you have a cold Paul? Reply Karen Karen 10 months ago An hour and a half into discussion and not clear where the red meat discussion is suppose to be. Rattling off metabolic pathways without clarifying the diet aspect of it wasn't helpful for practical application. I respect the work and knowledge of both men, but perhaps this discussion was too technical for me. 🤔🙂 Reply ooGento ooGento 10 months ago Bruh everyone eating meat and whatnot and people still leaving a wonderful healthy life. Dont compare people who eats sugar everyfreaking day and go to mcdonald and etc. What are you talking about, nature is nature you cant go against it, you're gonna age no matter what! Reply Pespsi Jackson ● Pespsi Jackson ● 7 months ago paul is afreak Reply Torch_Vs Torch_Vs 10 months ago Key word You think Reply Patrick Lewis Patrick Lewis 1 month ago Semaglutide bull shit or not Reply Rtan Barter Rtan Barter 10 months ago What's up with Sally Jessie Raphael glasses lmfao Reply Mark Blackburn Mark Blackburn 7 months ago FFs not this fraud Reply Dr Crispy Johnson Dr Crispy Johnson 10 months ago Rat chow scientism. Reply Alejandro Mut Alejandro Mut 10 months ago Sinclair is a clown. 4 Reply 10 replies MonopolyJ1 MonopolyJ1 10 months ago I didn’t enjoy this guy. His got vibe of arrogance and weirdness Reply Haleman Haleman 10 months ago Dude you look starving and need to eat more carbs 1 Reply heaven's heaven's 10 months ago Tldr, it won't. Reply