Attia MD with Matt Kaeberlein, Ph.D. on How nutrition impacts longevity

How nutrition impacts longevity | Matt Kaeberlein, Ph.D. Peter Attia MD 214K subscribers Subscribe 1.6K Share 74,278 views Sep 12, 2022 Watch the full episode and view show notes here: https://bit.ly/3x7I1hs Become a member to receive exclusive content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Dr. Matt Kaeberlein is a globally recognized expert on the biology of aging and recurring on The Drive. In this episode, Matt explains his research findings on nutrition as it relates to aging and longevity, including the results from his recent review article in Science. From there, he and Peter dive deep into the literature on calorie restriction (CR), explaining the nuance, benefits for lifespan and healthspan, and potential downsides of CR. He discusses the epigenetic changes that occur with age and potential benefits and downsides of epigenetic reprogramming, often viewed as a panacea for reversing aging. Matt also explains the impact of dietary protein on aging, including the interesting dichotomy around how protein, a critical macronutrient, and rapamycin, a geroprotective molecule, have opposite effects on mTOR. Additionally, he talks about low-protein vs. high-protein diets and their effects on muscle mass and mortality, as well as the impact of IGF-1 signaling and growth hormone on lifespan. We discuss: 0:00:00 - Intro 0:00:08 - Challenges with understanding the effects of nutrition and studying interventions for aging 0:05:26 - How Peter’s and Matt’s convictions on nutrition and thoughts optimal health have evolved 0:14:48 - Calorie restriction for improving lifespan in animal models 0:21:05 - Utility of epigenetic clocks and possibility of epigenetic reprogramming 0:32:09 - Mutations and changes to the epigenome with aging 0:36:21 - Epigenetic reprogramming: potential benefits and downsides and whether it can work in every organ/tissue 0:44:43 - First potential applications of anti-aging therapies and tips for for aging well 0:49:40 - Impact of calorie restriction on the immune system, muscle mass, and strength 0:59:34 - Insights from famous calorie restriction studies in rhesus macaques 1:09:18 - An evolutionary perspective of the human diet 1:19:10 - Antiaging diets: Separating fact from fiction—Matt’s 2021 review in Science 1:27:39 - Mouse models of time-restricted feeding in the context of calorie restriction 1:36:38 - Nutritional interventions that consistently impact lifespan in mice, and concerns around efficacy in humans 1:41:46 - Differing impact of calorie restriction when started later in life 1:49:02 - Lifespan extension with rapamycin in older mice 1:55:38 - Relationship between protein intake and aging, and mouse studies showing protein restriction can extend lifespan 2:04:07 - Impact of protein intake on mTOR, and why inhibition of mTOR doesn’t cause muscle loss 2:09:37 - Low-protein vs. high-protein diets and their effects on muscle mass, mortality, and more 2:22:16 - The impact of IGF-1 signaling and growth hormone on lifespan 2:37:23 - Parting thoughts on the contribution of nutrition to healthspan and lifespan -------- About: The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 45 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life). Learn more: https://peterattiamd.com Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies. Chapters View all 280 Comments rongmaw lin Add a comment... Peter Attia MD Pinned by Peter Attia MD Peter Attia MD 3 months ago In this episode, we discuss: 0:00:00 - Intro 0:00:08 - Challenges with understanding the effects of nutrition and studying interventions for aging 0:05:26 - How Peter’s and Matt’s convictions on nutrition and thoughts optimal health have evolved 0:14:48 - Calorie restriction for improving lifespan in animal models 0:21:05 - Utility of epigenetic clocks and possibility of epigenetic reprogramming 0:32:09 - Mutations and changes to the epigenome with aging 0:36:21 - Epigenetic reprogramming: potential benefits and downsides and whether it can work in every organ/tissue 0:44:43 - First potential applications of anti-aging therapies and tips for for aging well 0:49:40 - Impact of calorie restriction on the immune system, muscle mass, and strength 0:59:34 - Insights from famous calorie restriction studies in rhesus macaques 1:09:18 - An evolutionary perspective of the human diet 1:19:10 - Antiaging diets: Separating fact from fiction—Matt’s 2021 review in Science 1:27:39 - Mouse models of time-restricted feeding in the context of calorie restriction 1:36:38 - Nutritional interventions that consistently impact lifespan in mice, and concerns around efficacy in humans 1:41:46 - Differing impact of calorie restriction when started later in life 1:49:02 - Lifespan extension with rapamycin in older mice 1:55:38 - Relationship between protein intake and aging, and mouse studies showing protein restriction can extend lifespan 2:04:07 - Impact of protein intake on mTOR, and why inhibition of mTOR doesn’t cause muscle loss 2:09:37 - Low-protein vs. high-protein diets and their effects on muscle mass, mortality, and more 2:22:16 - The impact of IGF-1 signaling and growth hormone on lifespan 2:37:23 - Parting thoughts on the contribution of nutrition to healthspan and lifespan 17 Reply 2 replies Tomáš Knespl🇨🇿 Tomáš Knespl🇨🇿 2 months ago Please, have another conversation with Matt soon! You are an awesome duo! 9 Reply Don Spradley Don Spradley 2 months ago Love love love this episode!! The way you two broke down all these “studies” and the context of them is the most empowering kind of knowledge we can use in this complex conversation. Love this❤ 1 Reply 1 reply B. Newsome B. Newsome 2 months ago Attia, your views on training and fasting have changed my life man.. keep it up 10 Reply KST KST 3 months ago Excellent & thought provoking & answered a million questions I had in my mind - having heard other takes on the same data it was put into proper context with limitations & exactly which evidence was or wasn’t provided. The time flew by and sad it ended! Thank you Matt & Peter in equal measure. Outstanding conversation. :) 15 Reply 3 replies Shanteen Shanteen 3 months ago (edited) Yet another amazing and informative episode. Thank you Peter so much for sharing this! It answered some of the nagging questions I've had about CR, DR, mTor and Rapamycin. Can't wait until the next episode! 3 Reply Lucy Cooper Lucy Cooper 3 months ago Dr. Peter Attia 🙌 Bringing worldly scientific information together so we can optimize our health. Thank you 👏 3 Reply chaz wyman chaz wyman 3 months ago (edited) One size fits all does not always work, but i think this is less about being different genetically, and more about how each of our dietary experiences, and current fitness and size. Most general advice can work for all, maybe not straight away, but once you are on the road to metabolic health the differences in advice are reduced. For example "calorie restriction" if you are fat leads to lower metabolism, tiredness and severe hunger. For the lean and fit it just means trimming up. Fasting is more effective for fat people as this tends to avoid many negative effects. 2 Reply Neobellator Neobellator 3 months ago Agreed. Muscles are indeed like sinks for sugar. Need to make sure muscle mass is maintained in the long run for optimal longevity along with other interventions. Great discussion on this topic! Really strikes some of the curiosities out. 3 Reply susy may susy may 2 months ago Nice timestamps! 🙂 Please keep this up! 1 Reply Bob McIver Bob McIver 3 months ago 👍 Great Conversation!Big Picture:Optimizing any complex system eventually runs up against 'optimizing' the system to a fragile state where messy evolutionary randomness and variation have been restricted. Not suggesting we throw up our hands in despair but some of Tim Ferris' 80/20 mentality is in order as you both pointed out. Reply Bards Amok Bards Amok 2 months ago Has Peter provided a video of his ideas on how to avoid functional / pathological downsides of frequent deadlifts yet? He mentioned doing this explanation a couple of months bacK, but I don't know if it's on a different upload platform or his website etc.. or if he hasn't got round to it yet. I think it's based on avoiding or reversing imbalances from doing deadlifts by his ideas on correcting technique in a nuanced way. 1 Reply 1 reply Fernando Almaguer Fernando Almaguer 3 months ago This was a really good listen. Thanks gentlemen! 4 Reply divesh85 divesh85 2 months ago Carrot is indeed less risky than a protein bar, and i agree that you guys did not settle on anything. In the protein and muscle discussion with Don Layman, there were easy take aways and you guys pretty much concluded that protein is the most important component of our food. This discussion was very open ended and it made it clear that this is pretty complicated stuff, and that for every dietary recommendation there are 10 other counter recommendation. I like the conclusion though, that we should focus on the 80% which is pretty simple and straightforward - eat well, excercise. 3 Reply 3 replies Rick Rude Rick Rude 3 months ago The question should not be what is better for longevity, high protein or low protein. The question should be what is an adequate amount of protein in grams per bodyweight when coupled with two or three brief resistance workouts per week to maintain or slow the loss of muscle mass and strength in older adults. 7 Reply 2 replies Iliana Holbrook Iliana Holbrook 2 months ago I love the information you provide Reply Mark T Mark T 2 months ago (edited) I am surprised that when comparing the Wisconsin and Bethesda research results; as mentioned was the difference in “quality” of diet - Not discussed was that the poor diet of the Wisconsin test had such high levels of sugar and restriction of calories would have reduced sugar intake. This alone could have impacted metabolic health and made the difference in longevity. 2 Reply Davison (DavisonVideo) Davison (DavisonVideo) 2 months ago (edited) You guys are great!! I'm doing an antiaging series called Regenerative Antiaging on a new channel. Thank you for doing the work that you do!! 😊 Reply 1 reply Iliana Holbrook Iliana Holbrook 2 months ago I love the information you provide Reply 1 reply Jovan Lazarevski Jovan Lazarevski 2 months ago This is how a true scientist sounds like. Not overinterpreting data, distinguishing between mice and human data, mechanistic vs outcome data. A stark contrast to Sinclair. 1 Reply Konadubya Konadubya 3 months ago (edited) When I think of centenarians I think of routine life , walk in park or gardening , drinking coffee, light breakfast, family and social connections . A person I've always though of growing up was noam Chomsky. Nothing too crazy in terms of fitness or nutrition. 17 Reply 3 replies Ange Los Ange Los 3 months ago (edited) So the take home message is 2:42:30 "You can get most of the benefits without worrying a lot about all of that". Nonetheless, it was an interesting episode. 12 Reply 2 replies Ian Mills Ian Mills 1 month ago (edited) I think we have to beware that experimental animals aren't suffering for our curiosity in the trivia of non essentials. The value, quality and appreciation of life is not just based on how effective we are at optimising our longevity and physical performance. Reply blase baker blase baker 3 months ago Great information. Thank you! 2 Reply Marlene Manez Marlene Manez 3 months ago I would love to find out what in“ bucket” I am. I just turned 60 and I keep a good amount of muscle( I lift every other day and I run 3timesa week) but I think that I’m over nourished. Do you take new patients Doc? 1 Reply 7 replies az stuff az stuff 3 months ago (edited) Excellent discussion. 1 Reply Pavel Chorda Pavel Chorda 2 months ago Peter, this is one of the best podcasts you did, as a biologist I could not agree more about the complexity of the dna - rna- protein expression/regulation. I finished my studies 25 years ago, I was completely into the topic of longevity, but in those years you could not find anything, then because I was always practicing martial arts I began to learn about Taoism, because is not a a religion of belief and they always emphasized longevity. This was an amazing discover, longevity connected with reproduction, life style including mastering the emotional reactions through meditation, sleep, contact with the nature etc, if inflamation could be the determinant factor to produce better functional proteins, the Taoist mastered how to reduce it, even deeper, they already were meditating in re-programing or inducing the youth in a damage system. As we know during the sleep, in some phases we are really effective and efficient in cleaning up our zombie cells 😉 etc, if you analize the sleep in terms of brain waves, you can see causation and correlation, as deep meditation states can reproduce those brain patterns being awake, could this also influence such processes? I'm not talking about 8 weeks mindfulness training obviously, I'm talking about people who really know what they do and they are able to reproduce such states in any moment and in few seconds. This is my passion as scientist. 1 Reply Robert Jones Robert Jones 3 months ago Attia's Rule asserts the primacy of exercise. Matt mentioned that the CR mice were far more active than the ad lib mice. It seems to me that Attia's Rule would indicate that the increased longevity of the CR mice was the direct result of exercise and not CR. It would be easy to set up an experiment to confirm that. 2 Reply 3 replies mark veen mark veen 3 months ago (edited) I've seen healthy centenarians on all kinds of diets and lifestyles(sedentary). Most of them never had supplements or "superfoods". Some of them also had alot of inflammation or even cancer in the past. Nothing beats good longevity genes. However, that being said. I do believe most people will thrive on a more mediterranean style diet. High in glycine, low in methionine. Again, diet is just a small piece of the longevity puzzle. 11 Reply 3 replies Matthew Perkins Matthew Perkins 2 months ago Peter it feels like you’re doing everything in your power including interrupting, to get Matt to say that high protein is the right nutrition strategy. Reply Bjorsa M Bjorsa M 3 months ago I appreciate the humility and cautiousness displayed. Between the lines perhaps to be found some criticism of David Sinclair? Going back some 15 year he presented his whole rapamycin thing ...roundly. If not, then at least the Aubrey de Grey crowd? 5 Reply 7 replies Faimohkih Faimohkih Faimohkih Faimohkih 2 months ago It’s pretty crazy to me that during this whole 2 hour discussion about nutrition there’s hardly any mention of the nutrient density of food or the study of adequate/optimal levels of vitamins/nutrients in humans. I was hoping to hear some studies on comparing those with optimal micronutrient levels vs those with micronutrient deficiencies and health outcomes. Do those studies not exist? Reply 1 reply Rubens Onorio Rubens Onorio 3 months ago @Petter Attia MD very interesting video. Thanks for sharing 👏 Reply Rishabh SHARMA Rishabh SHARMA 2 months ago Need a session with Dr. David Sinclair and Matt moderated by Dr. Attia 2 Reply 1 reply Teddy P Teddy P 3 months ago Great conversation. Please invite Herman Pontzer and Don Layman too. 1 Reply Scott K Scott K 3 months ago Amazing interview, as always with Matt. Also as always with Matt, he still has the worst case of "right?" I've ever heard. 3 Reply 1 reply tywatts17 tywatts17 3 months ago I wonder how longevity and health span metrics are effected with eating in a small caloric surplus for many years attempting to put on lean mass. Reply Erast Van Doren Erast Van Doren 2 months ago (edited) Peter, this article “Training for Longevity: The Reverse J-Curve for Exercise” (YouTube doesn't like links) suggests that 50 MET/week is optimal. 1 Reply 6 replies Tom Tom 3 months ago Im in my 20's and have put on a LOT of muscle eating max 50g protein per day. It could very well be that high protein intake is what causes the huge decrease in quality of life at 75 that you talk about. Unless you are finding it very hard to put on muscle, need to put on a lot of muscle in a short time frame or are actively losing muscle, it would be my recommendation to eat low protein and do resistance training - and I think this approach is supported best by the data. 5 Reply 22 replies Dale James Dale James 2 months ago I admire this guest's epistemological skepticism in regard to the potential benefits of diets or in regard to the potential interpretation of studies. There is a blight of people conflating claims. Thanks 1 Reply Daron Cresstwell Daron Cresstwell 2 months ago Keep up the good work. A separate podcast on protein-muscle-lifespan-healthspan would be great. I never quite believed the the BS that "you must pick one- high protein for muscle and quicker aging low protein for better aging but weaker muscles. I am a lean athlete/scientist that had an approximately 40:30:30 carb:protein:fat split whether i am on maintenance or a mini-cut and very happy with it. Reply 2 replies Lois Beauty Luxe Lois Beauty Luxe 2 months ago Great conversation xox Reply 1 reply Alexis Espinosa Alexis Espinosa 3 months ago (edited) Thanks for bringing Matt so many times, and I hope for a lot more in the future to to keep hearing from his research and knowledge. But, what about Valter Longo? He has so much to add and fill gaps of this podcast and still he has not been in the show. I really wonder why? Longo is such a big figure in the topic, that I have always been puzzled about your decision of keeping him out of the conversation. For me it is almost like letting down your audience and subscribers. Why? Why such a strange decision? At least I think your audience and subscribers need an explanation on why Longo has not yet been in your show. Could you explain? Or better, invite him soon? Thanks a lot for your amazing podcast! 3 Reply 9 replies MagnesiumAddicts MagnesiumAddicts 2 months ago I wish I could focus on these sort of optimizations, but I'm stuck with 90% carnivore because it's the only thing that eliminates my chronic joint pain and periodic gout :( 2 Reply 3 replies kim andre blikås kim andre blikås 3 months ago great one! Reply Matthew Dean Matthew Dean 3 months ago Yesss! Thank you 🙏🏼 Reply Kamanashis Roy Kamanashis Roy 3 months ago What about 5 day fasting ? How does it compare to calorie restriction? Reply alan2102 alan2102 2 months ago Dear Peter Attia: on this video: https://www.youtube.com/watch?v=jKyYvna5VjA .... you mention two case histories: yourself, and a patient of yours. In both cases there were quite notable (and in the case of the patient, alarming) increases in body fat percentage, over time, with fasting -- mostly time-restricted eating (aka IF), but in your case longer fasts episodically as well. The patient went from 18% to 30% body fat (a huge gain) and you went from 10% to 16% -- less extreme, but still remarkable for an extremely healthy man doing regular strength and other training, and presumably on a great diet. This is a very striking and concerning observation, even though it is only two cases. Have you, or others, observed more cases like this? Is this a pattern, i.e. of fasting tending to cause unfavorable body composition change? I believe these to be extremely important questions, worthy of thorough examination. Perhaps you have addressed this somewhere. If so, where? In the cited video you speculate that lack of strength training is the cause, and that the reason that your own personal strength training was ineffective was because you did it in the morning, before eating. Is there any evidence for these views? Thanks for all your work. Sincerely, Alan Reply 1 reply ItsDangerousTobeweakBOII ItsDangerousTobeweakBOII 2 months ago Great discussion - on the Valter Long study - the mortality rates using the regression model or so called "Cox Proportional Hazard Model" is distortionary of the risks as Attia identifies - the absolute proportion or % of deaths below age 65 are not disclosed but instead the relative risk of dying from is. So you could say the model shows you are x times more likely to die from cancer on a high protein diet before age 65... but leave out the fact that only small percentage of people of several thousand studied died from that cause. Over 65, the absolute proportions of people who die from any cause skyrockets so it is much more important to focus on diminishing that risk. Valter needs to disclose the numbers more transparently. 1 Reply 1 reply susy may susy may 2 months ago Comments on the often heard theory that protein restriction up to roughly 65 but bulking up on protein after that is the way to go? Reply Epigenetic Nerd Epigenetic Nerd 2 months ago I don’t see how the epigenome wouldn’t be a major aspect that influences aging, considering it’s entirely responsible for which genes continue to turn on and off. Reply fakhar ahmad fakhar ahmad 3 months ago Would have been amazing if David Sinclair was also present on this podcast as has a slightly different point of view. 1 Reply 2 replies Alexis Espinosa Alexis Espinosa 2 months ago Is Attia not water-only long-fasting anymore? Reply Bungifun Bungifun 3 months ago Ancestral diet.. you had to be flexible only when there was little choice. Large and very large animals were preferred as they provided more than just food. There are no indications that we had long periods without these animals except as of roughly 12000 years ago so yes a diet of primarily meat and fat is likely the optimal diet for health Reply 4 replies K. Wiljanen K. Wiljanen 3 months ago Fun fact: Dr Matt is 107 years old! 11 Reply T E T E 3 months ago I appreciate how cautious he is with his statements. That's pretty rare. Hyperbole is the name of the game with most health gurus. 12 Reply 4 replies chaz wyman chaz wyman 3 months ago There is no such thing as age, or aging. All bodily tissues and their ability to repair and be replaced wear out with time. All bodily tissues wear out at different rates and different tissues wear out at different rates in different people. The war in favour of long life has to have a massive range of different personalised treatments and practices. 2 Reply Konadubya Konadubya 2 months ago Like to see someone summarize this. Lol 2 Reply 3 replies Kamanashis Roy Kamanashis Roy 3 months ago With due respect, calorie restriction does not make me hungry all the time. You get habituated after some time. 4 Reply Donald Prigo Donald Prigo 2 months ago Do you recommend taking rapamycin supplements. I’m 75 and in good health. Reply 1 reply mark tapley mark tapley 1 month ago Other than good genes, the biggest factors for extend life span and good health are sanitation and good nutrition. Once industrial societies these primary components, average lifespan drastically increased due to huge decrease in childhood mortality. This major advancement was achieved and the so called “infectious" diseases were all practically eliminated before modern medicine or vaccines. Read Suzanne Humphries MD “Dissolving Illusions." Reply thejemag thejemag 2 months ago Regarding the epidemiologic study of protein consumption, isn't it likely that those who consume less protein tend to consume more fruits and vegetables and that is where they get their benefit. It is just that at age 50+, the downstream negative effects of having a low protein diet just overcomes the benefits of having more fruits and vegetables. 1 Reply 1 reply chaz wyman chaz wyman 3 months ago Mice are genetically identical, and often oncophilic. Reply Nancy J79 Nancy J79 3 months ago I'd bet my life that most of this comes down to blood sugar/insulin management by matching calories from carbohydrates to glycolytic activity. 1 Reply Deep Dusto Deep Dusto 3 months ago Well in this world there are 2 types of people and if I am the Observer, I see: Camp A: Oh its too complicated, its so messed up, I am going to head out to build some muscle, so I can't really spill the real deal to you, so just follow me people. Camp B: It is possible, it can be done. Its exciting what future holds, let us all understand this people, here is the explanation for you curious minds. Observer: Hello Camp A: 2 yrs ago, I only had you to listen, but today there is Camp B and boy that sounds promising. So now I have little interest in listening to your big pharma friendly. Over. Reply Alexis Espinosa Alexis Espinosa 1 month ago Indeed, when whole food diet is appropriate to the Monkey, then Monkeys do not get longevity benefits from caloric restriction. And I believe any study report/paper should be put aside (or in the trash bin) if the control diet/lifestyle is not the optimal/correct one. So, to start with, if the control diet is the SAD (or an emulation of it) the study becomes rubbish by definition: anything is better than SAD. But the same effect is true if the diet is not really the best one for the organism. Has it really been established that rat chow is the best food for lab rats? In my opinion there is sort of evidence that rat chow tends to damage metabolism of the rats and make the diabetic/pre-diabetic, reason why many anti-diabetic drugs have shown longevity benefits in the ITP. I know this may sound controversial, but yes, maybe the ITP reports need to be but aside until it is proven that rat chow is the best diet for rats. And same goes for the Dog Aging Project and the TRIAD, who has proven that dog chow is the best food for dogs? Would it be better whole foods for them? Who with a bit of intuition would think that giving industrial food to dogs would be the best possible diet for them? Then maybe, the results form Dog Aging Project and TRIAD should be put aside as the control group may be receiving a sickening diet to start with. Reply Lee Lee 2 months ago All discussion about calorie restriction is meaningless until you describe exactly the amount of restriction. Is it to a particular BMI? Bodyfat percentage? That being said, if you look at the elderly, muscle mass is protective of mortality with more mass being more protective. It is also protective of cognitive disease. You simply aren't going to have much muscle mass if you do very much CR. You won't have muscle if you don't eat. The animal studies showing the wonders of CR just don't translate to humans. Reply 4 replies Hugo Zuleta Hugo Zuleta 2 weeks ago We talk a lot about mice laboratorio experiments. What about people in Japan that live longer than another country and they have less cancer and illnesses. I think we should study these people and the eating habits .why spending time and money in mice that we are not sure if really apply to human being body 🤔 Reply Geekspeak10 Geekspeak10 2 months ago I’ll stick with my ad lib animal based diet with random periods of fasting and plenty of exercise. My whole life is Risk Management centric and I’m sure hedging with drugs is worth it and could actually cause more harm then good. 3 Reply 4 replies Claudio Sanchez Claudio Sanchez 2 months ago (edited) After 2hrs and 43 mins the summary is: if you are not a Lab rat just eat healthy Reply Mike Valdez Mike Valdez 3 months ago (edited) Vo2 Max....... that's the key....if you have an exceptional Vo2max, & great bmi, you'll most likely live a long life.... 5 Reply 4 replies Raw and Cooked Vegan Raw and Cooked Vegan 2 months ago (edited) Fasting is required for health if your diet has animal products. If it doesn't, you can fast but you don't need to. Why do meat and fat eaters improve their health with fasting? Because at least for a short period they've stopped eating that which is harming them. Reply 1 reply RILEY (SlotDog) PLAYS SLOTS (He's a dog) RILEY (SlotDog) PLAYS SLOTS (He's a dog) 3 months ago He looks like a cross between Christopher Reeves and the guy from big bang theory. 5 Reply 2 replies Scott K Scott K 2 months ago (edited) I think these guys are far too quick to dismiss the theory that the optimal diet mimics that of our ancient ancestors. It's not that I think it is the optimal diet, because who knows? My issue is that they seem not to understand the theory. Peter lazily and somewhat obtusely dismisses the diet by slow-pitching himself the silly idea that caveman were sitting around pontificating their diet, which is an absurd straw-man of the actual theory; the theory being not that a "Paleo" diet is optimized for us, but rather the reverse of that, that over millions of years of evolution, we have been optimized to a Paleo diet, because that is what our body evolved to consume. In other words, they are looking at this backwards. Almost as if they were to say "we don't know if oxygen is the optimal respiratory gas for humans, because caveman didn't sit around pontificating about breathing." But oxygen is essential to us, not because it's tailored to us, but because we are tailored to it. Oxygen is what is around, and so we evolved to utilize it. That is the theory for the Paleo diet. We evolved to eat what was around. Our system is tailored to those foods. Again, who knows if that theory is valid or true? It just bugs me that they dismiss the possibility, seemingly without bothering to understand the theory behind it. 1 Reply 1 reply Maggie Ensley Maggie Ensley 3 months ago Damn how many of these do you put out to where not a single comment is responded to. I have questions but I refuse to ask them😑 1 Reply Y. G. Y. G. 2 months ago The more you listen to them, the more you get amazed by their astonishing stupidity, carefully hidden behind quasi scientific jargon. 1 Reply 2 replies jason deets jason deets 3 months ago Mice mice mice mice mice mice. This was a talk on mouse studies. I was seriously thinking about listening to the whole thing over and counting how many times the word mice was used. As much of a man crush I have on Peter and with how fascinated I am with nutrition studies, I kinda regret investing the amount of time I did in listening to the whole thing. Stayed very true to the title though with the longevity correlation to certain nutritional studies. 1 Reply 3 replies Raju K E P Raju K E P 4 weeks ago 1:08:08 Reply Anita Anita 3 months ago My grandmother lived active at 104 and didn't eat high protein. I just don't like the generalities. When I eat high protein my a1c goes into prediabetic range. 2 Reply 2 replies peous paul peous paul 2 months ago climate play important role in health , sustainability.. indian hot climate not suitable for non vegetarian.. for a vegetarian life in India is comfortable and sustainable.. Reply David Hale David Hale 2 months ago Having a Peter Attia Health and Aging certification in Health Span and Life Span would be nice. He has valuable information and research and has worked hard to understand it. To get his information out to even more people it would be nice to have a certification that allows people to speak authoritatively about it without dipping into licensure over diet advice and medical dietary cures for diagnoses. Reply 1 reply kurt housh kurt housh 2 months ago Following Peter for years has shown me all science is wrong or incomplete. He changes his dietary n of 1 experiments every few years when new data is released and will change his protein consumption soon. 🤣 Reply 1 reply Pierre X Pierre X 2 months ago In a nutshell, David Sinclair is a snake oil salesman. 2 Reply 2 replies Geekspeak10 Geekspeak10 2 months ago Interesting that Matt hand waves looking at ancestral data to inform what modern humans should eat. Other research indicates that we are specialist carnivores as opposed to opportunistic omnivores. 1 Reply 2 replies Claudio Sanchez Claudio Sanchez 3 months ago interesting but a lil bit long Reply Jiří Hutečka Jiří Hutečka 3 months ago (edited) No word about toxicity of any kind and disbalance of micronutrients of any kind? I hear on this channel only about keto this, vegan that.. It's not just about calories, proteins, carbs and fats. What about minerals. They run the show.. A lot of talk about hormones that is great, but what is before hormones? Minerals.. So just because you are fasting, doing keto or whatever doesn't mean that your body has all the minerals in right balance.. If you want talk about longevity start with iron overload for example. Especially for males.. So lover iron by donate blood etc.. That is the basic stuff that should be addressed first. Or if you have amalgams aka mercury toxicity and that depleted your selenium etc.. Or you have low zinc and copper toxicity etc.. That is what makes you healthy not if you are doing high carb low fat or keto.. Most people are deficient in key mineral molybdenum. Do you even heard about this mineral Peter before? That is foundation for good hormone profile and overall health. To know your metal/mineral status etc.. Not if you fast for 6 or 12 hours a day or whatever.. Also protein what is protein. It's protein from muscle meat or from gelatin? Completely different amino acid profile. So how effect single amino acids the body etc.. Also all this talk about mouse studies. We are not mice in the lab btw... So completely irrelevant to talk about it and waste of time.. 7 Reply 4 replies WorldNomad WorldNomad 3 months ago Hey Matt, when did nutritionist’s say you could eat low fat and not become overweight? I’m pretty sure you just made that up. It is true that many cultures eat low fat and are skinny, look at the Okinawans or even the Hadza for that matter. Kevin Hall’s metabolic ward study already proved that low fat is more satiating than low carb. The low fat group consumed 700 less calories than the low carb. 3 Reply 22 replies Dwight Morgan Dwight Morgan 3 months ago What is a met hour? 2 Reply 1 reply Peter Coderch Peter Coderch 3 months ago Peter Attia is a no-nothing. He obsesses over lipidology and cardiovascular disease, while at the same time advocating low carbohydrate diets for "insulin sensitivity" that are loaded with fat, including animal fat which is the primary cause of arteriosclerosis. Oh don't worry 'cause Attia has a solution for that, too: lowering the increased ApoB that comes from such diets with statins! Because, of course, a diet that can only be made healthy by taking medication with it is good for you. Never mind that statins cause insulin resistence, the same condition that Attia claims to be so concerned with to put people on these low carb diets, and that statins also cause dementia, when Attia claims to be very concerned with dementia among the elderly, he sees no problem prescribing drugs that induce dementia to control cardiocascular disease. Also, Attia is a huge fanboy of sirolimus, a drug that at best prolongs lifespan by a miserable 9%, and even that only on short-lived species. There is no evidence whatsoever that rapamycin prolongs lifespan on Humans. Never mind that rapamycin is an extremely toxic drug that causes everything from immune suppression and recurrent infections to jaw necrosis, osteoarthritis and a host of other problems. Rapamycin carries a black box warning from the FDA, reserved only for drugs that are either addictive or have the potential to cause death at clinical doses. But never mind, folks. When Attia figures out the "correct dosage and protocal", we will all be taking it! It's like taking stricnine for heart problems: don't forget to properly calibrate the dosage or you're dead in seconds! And did I mention that at best this drug prolongs lifespan by 9%, which in human years is about 6 years. 6 years of extra lifespan(at best) in exchange for losing all your teeth, having your bones rot and fracture, and becoming suicidally depressed. Because one of the most common side effects of MTORC-1 suppression is depression. In fact, ketamine reverses depression by inducing MTOR. I wonder how Attia will feel when several of his patients that he put on rapamycin for "life extension" committed suicide over the severe depression that this drug often induces. So to recapitulate: you lose all your teeth, live with chonic infections, become suicidally depressed and impotent for, at best, an extra 6 years of life. Wheeee whooo! Great! Notice how almost every guest that Attia has on his podcast are medical doctors like him. Attia is an "establishment guy". He is a big supporter of the medical establishment. You know, the guys that, after 100 years, have not been successful at doing anything about ageing. Those are the guys that Attia has on his podcast. They have not succeeded in over 100 years, so why will they now? Most of the gains of longevity of the past 50 years have been from people smoking less. Medicine has done literally nothing to decrease the disabilities of old age and prolong human lifespan. Notice how Attia has never had on his show any true visionary like Aubrey De Grey, Vadim Gladyshev, Bill Andrews or George Church. No: he only has his buddies from the medical establishment, who are utter failures at dealing with ageing. Attia has also made it clear that he doesn't believe in radical life extension and that he thinks that anything more than maybe prolong Human healthspan by a few years is possible. The only pure scientist that he has had on his show is David Sinclair. Everybody else is a medical researcher. The guys that treat cancer with radiotherapy and chemotherapy, causing even more DNA damage and fostering cancer more. The guys that treat hard disease with statins, drugs that cause insulin resistence and dementia. 4 Reply 3 replies zxsw85 zxsw85 2 months ago Absolutely stud guest and conversation Reply 1 reply Scott K Scott K 2 months ago Man, Peter is really interrupty in this one. 2 Reply Trish Marck Trish Marck 3 months ago We are over fed and under nourished Reply mark tapley mark tapley 1 month ago This podcast is way too long. All of it could have been easily and more effectively covered in one hour. Reply S C S C 3 months ago It was the nandrolone lol Reply LISA Keever LISA Keever 3 months ago I need a strategy do you take Clients Reply peous paul peous paul 2 months ago health and sustainability always related with microbiome diversity.. microbiome make important nutrient for human health .. most modern society missing microbiome diversity... because lack of food diversity, lack of fiber in food .. most modern diseases such as autoimmune and cancer retaled to missing microbiome .. Reply mark tapley mark tapley 1 month ago Yeah, don’t hold your breath for any of this stuff. As an example, how many genetic diseases and mutations have they cured since mapping the human genome many years ago? Thats right, None. Reply mycomage mycomage 3 months ago Hey Dr Jack Kruse on 2 Reply J.R. Kizziar J.R. Kizziar 3 months ago W Reply js op js op 3 months ago Peter, Mice are not little humans, not reliable data 2 Reply Trish Marck Trish Marck 3 months ago I feel most of your interviews are only supporting your bias. How about interviewing people like Dr Ornish, Dr Campbell etc and those who may have a different view than you do. 4 Reply 1 reply Jeanne Iben Jeanne Iben 3 months ago So self absorbed. Lots of the people who are trying to live forever aren't very relevant for humanity. Reply 1 reply EMMA LUCIA EV EMMA LUCIA EV 2 months ago (edited) What a waste of a wonderful guest, It was a bad investment of 3 loooooonnnnggg hours talking monkeys and mice, The excess of acronyms Peter uses, omg, as if we the lay public could understand, actually saying the whole words, most of the time, takes less time, I couldn’t help but get lost mr. met hours Reply 1 reply Pakistanicecream STEM-Talk Episode 139 with Matt Kaeberlein TheIHMC 78.1K subscribers Subscribe 40 Share 2,312 views Aug 16, 2022 Full shownotes: https://www.ihmc.us/stemtalk/episode-... In response to several requests from listeners, we have as our guest today, Dr. Matt Kaeberlein, a professor of pathology at the University of Washington. Matt is well-known for his investigations into the basic mechanisms of aging. Much of his research in this area is focused on identifying interventions that promote healthspan and lifespan. In today’s interview, we talk to Matt about the biology of aging and what he has learned about slowing the aging process. In 1999, Matt and his colleague Mitch McVey discovered that overexpression of the SIR2 gene is sufficient to extend lifespan in yeast. SIR stands for silent information regulator, and we have an interesting discussion about how Matt’s research and 1999 discovery have elevated SIR2 to the forefront of aging research. Also, some of Matt’s most recent and fascinating investigations have been into rapamycin, the only known pharmacological agent to extend lifespan. His research has shed new light on the role rapamycin plays in delaying age-related dysfunction in rodents, dogs, and humans. We also have a fun discussion with Matt about his research showing that rapamycin may have the potential to reduce the mortality of companion dogs. The paper that came out of this research landed Matt on the front page of the New York Times and received prominent play in the national and overseas media. Other topics we cover include: Matt’s attempts to uncover the molecular mechanism behind lifespan extension via calorie restriction. His research into mTOR, which is a protein in every cell, and how inhibiting mTOR has been shown to extend the lifespan of insects, rodents, and animals. Matt’s 2006 study that showed fasting extends lifespan in worms more than caloric restriction. And an article Matt published last year that summarized several of the most popular anti-aging diets, comparing them with classical caloric restriction. In addition to his work in his Kaeberlein Lab, Matt is the co-director of the Nathan Shock Center of Excellence in the Basic Biology of Aging and the founding director of the Healthy Aging and Longevity Research Institute at the University of Washington. He also is the founder and co-director of the Dog Aging Project. Chapters View all 3 Comments rongmaw lin Add a comment... Patrik Molnar Patrik Molnar 3 months ago Make one with richard miller from NIA he s a honest scientist Reply Kamanashis Roy Kamanashis Roy 3 months ago Waw, I moved to Seattle from Erie too. Reply Patrik Molnar Patrik Molnar 3 months ago Algo Reply Pakistanicecream 3 months ago Boring