Combining AMPK and mTOR

Combining AMPK and mTOR a combining AMPK and mTOR is Stay on the Health Track 2.93K subscribers Subscribe 78 Share 1,559 views Jan 18, 2020 https://www.youtube.com/channel/UC_vI... An important anti-ageing strategy is to activate AMPK most of the time and mTOR some of the time. In this video we talk about the benefits of each, how to activate each, and who needs to activate more of which. A concrete strategy for a combining AMPK and mTOR is: Do time restricted eating, with a flexible 14 hour window of fasting and a 20 hour fast twice a week with vigorous exercise before you start eating. Make sure you do not take your AMPK boosters as you start eating, as you want to activate mTOR at that time. Take the AMPK boosters as you go into your fast. This is for informational purposes only and if you plan on making any changes you should always discuss them with your health practitioner before starting. A R T I C L E Read about AMPK, mTOR, and senescence in my article on this: http://stayonthehealthtrack.com/kill-... P A T R E O N Become my Patreon and get access to my books and other products at: https://www.patreon.com/basia T H A N K S T O Music from bensound.com. Chapters View all 9 Comments rongmaw lin Add a comment... Ignacio Cespedes Ignacio Cespedes 1 year ago Thanks! Timeframes? When pathways are activated, for how long? Example, eat animal protein, activates mtor for how long? Reply gary R gary R 7 months ago This is so incredibly helpful Thank you I take DoNotAge products Reply Eujanio Coutinho Eujanio Coutinho 3 weeks ago Complicated strategy 😀 Reply Rui-9-CS Rui-9-CS 2 years ago amazing video 2 Reply Stay on the Health Track · 1 reply Dane Fleur Dane Fleur 1 year ago Thank you. Reply Rui-9-CS Rui-9-CS 2 years ago Gynostemma is probably a better AMPK activator... 2 Reply Ray Davis Ray Davis 2 years ago Alpha lipoic acid. Dr. Ron Rosedale - ' The Critical Connection Between Protein, Cancer, Aging and TOR' Low Carb Down Under 447K subscribers Subscribe 1.3K Share 72,493 views Sep 16, 2017 Dr. Ron Rosedale is an Internationally known expert in nutritional and metabolic medicine and is with one of the founding fathers of the modern low-carb, high-fat, ketogenic diet community. Dr. Rosedale is a pioneer in applying concepts based on the biology of aging to reversing diabetes and heart disease through a nutritional approach that he developed to improve the cell function. His classic 2004 book 'The Rosedale Diet' outlines the key nutritional approach that has become a standard bearer for the healthy way to doing a low-carb diet successfully. Dr. Rosedale was founder of the Rosedale Center, co-founder of the Colorado Center for Metabolic Medicine (Boulder, CO USA) and founder of the Carolina Center of Metabolic Medicine (Asheville, NC). Through these centers, he has helped thousands suffering from so-called incurable diseases to regain their health. As a keynote speaker, he has appeared before such prestigious groups as the Eighth Congressional International Medical Conference on Molecular Medicine, the First European Conference on Longevity Medicine and Quality of Life, and many more. He has also been a guest on numerous national radio and television news shows. A .PDF version of the slides used in this presentation is available here; http://denversdietdoctor.com/wp-conte... Key moments View all 258 Comments rongmaw lin Add a comment... Metal Monkey Metal Monkey 5 years ago A brilliant man, way ahead of the pack because he hasn't bound himself to one particular dietary school/belief and instead is constantly revising his position according to the available data. 41 Reply Science Simplified Science Simplified 2 years ago Dr. Rosedale has a lot of good information and talks about things you don’t hear much of on YouTube or on the internet in general... I really think he could help a lot of providers if he posted more lectures that aren’t limited to a limited time frame where he could really go into some of these mechanisms... 10 Reply Drake Santiago Drake Santiago 5 years ago (edited) This is such a mind blowing presentation. While I found it quite informative, the only thing I would suggest is that Dr Rosedale make another version of this talk, where he removes some of the technical jargon, specifically related to biochemistry, so that a more simplified version can be available for lay audiences, who aren't acquainted with evolutionary theory and cellular biology. I consider myself pretty well versed in these topics in comparison to the average person, since I spend a lot of time reading books, watching presentations, and listening to interviews from leading researchers and doctors, and yet even I had to pause multiple times in order to fully comprehend this entire presentation. A more simplified version of this talk would go a long way to spreading this information. 43 Reply 7 replies S L S L 1 year ago I've been stunned by what I've been realizing and learning from him. Mind blown 2 Reply Intermittent Fasting And Keto Intermittent Fasting And Keto 4 years ago Been following Dr. Rosedale for some time now. One of the pioneers in healthy eating for sure! 5 Reply ineedhoez ineedhoez 2 months ago This was an interesting presentation and it's consistent with my own personal research that I've conducted on my body. I learned about the insulin index of food and managing the insulin load of my meals because of a disastrous one month stall. You calculate net carbohydrate plus 56% of your protein consumption. I found that I lost weight when my insulin load was less than 50. Based on his calculations, my protein load would be about 38 g A-day. If I add that to my 20 g of carbs, that puts me at about 58 for the insulin load. This tracks perfectly to what I experienced. I was on a low carbohydrate but not keto diet. Keto is 70% fat or higher. I was on a high protein diet but I was consuming 1400 calories A-day. I was 5'7 and 260 pounds. I gained 5 pounds in one month and increased my insulin levels from an 8 to a 19. I gained weight even though I was in a calorie deficit. It's physiologically impossible to burn fat if your insulin is over 10. I did a 48 hour water fast to lower my insulin levels. The 5 pounds fell off and I started losing weight again. It was an amazing exercise in the fact that calories in versus calories out is complete bs. Your hormones regulate everything. I used the insulin index of food to calculate a diet that worked for me. Ironically, I cut out pasta but added steak They have the same insulin impact. I was monitoring my blood glucose with a cgm and didn't see a spike, so I assumed that insulin was low!!!! Wrong!!!!! I switched to low insulin impact proteins bacon, duck, and shrimp. My caloric intake went up but my insulin levels and weight went down and stayed down! 1 Reply Diane Lasek Diane Lasek 5 years ago Doesn't get any better than this!!!! He is brilliant!!! 26 Reply 1 reply Roger Bird Roger Bird 5 years ago At 44:44, the good doctor says: "And it is really the garbage collection that will turn up to determining our health and our life-span." This is the most important sentence of the video and perhaps the most important sentence of the 21st century. 27 Reply jon hamm jon hamm 3 years ago This dude is almost N Tesla level genius...Ive followed him since Mercola published his article on Insulin long ago 10 Reply 2 replies Mark Mark 5 years ago Great presentation as usual! Still waiting for your new book to come out!!! :) 7 Reply Elly Demko Elly Demko 4 years ago Always great information. They myth of needing a lot of protein is dispelled quite well. If you get a chance, get Dr. Rosedale's Book. :) Thanks for posting. 3 Reply 2 replies Kinky Kinky 3 years ago Sure cleared up my questions about mTOR. It's great to see the explosion of recent research in these areas. 2 Reply Falk Falk 2 months ago Thank you for the very interesting lecture. The studies certainly explain and support the thesis presented. However, I think my body is intelligent enough to use proteins in the correct way, ie as building materials rather than fuel. 1 Reply 1 reply Dan Dan 5 years ago practical takeaway: this is potentially why alternate day fasting is so effective. given long enough the amino acids freed by autophagy will re-activate mtor so you don't in fact die after a week of no food and endlessly catabolise. the cycle completes around 4-5 days in, with a peak of autophagy two days in, which ok assuming a bell curve (it never is) means you only get 50% of the benefit, but fasting alternate days is a hell of a lot easier than 4 on/4 off days of eating... 15 Reply 6 replies Michael Mac Donald Michael Mac Donald 5 years ago Fantastic talk. Thank you 6 Reply J Sims J Sims 1 year ago (edited) A finely delivered lecture but one which requires a caveat. By far the largest driver of mTOR is insulin and this is further amplified by the modern diet in which regular glucose (via processed carbs) intake stimulates insulin throughout the day. A high protein intake on a background of hyperinsulinaemia might well exacerbate high mTOR activation but on a low carb diet, and particularly one in which there is ancestral-like restricted time eating, a high protein dietary intake will result in negligible adverse effects of mTOR stimulation. Evidence from studies of hunter-gathering tribes (including the modern ones) indicates that they have very low incidence of cancers despite consuming significantly higher amounts of protein (up to 30% or more of calories) than their westernized counterparts. 9 Reply 1 reply 250txc 250txc 1 year ago (edited) 4:15 -- 'This is really where the action is. This is where the party started.' Just too cool! 2 Reply Sam NZ Sam NZ 2 years ago good doctor...very informative video 2 Reply SSLW Wall SSLW Wall 3 years ago Thinking twice about my protein consumption. Very interesting 5 Reply Alex Peikary Alex Peikary 5 years ago Thank you Dr. Ron Rosedale 5 Reply Eugene Lynch Eugene Lynch 2 years ago I can't wait to read the new book! 2 Reply Joe Tart Joe Tart 5 months ago My big concern is sarcopenia due to aging. A low protein diet will contribute to sarcopenia, resulting in a weak, frail elderly person more likely to break a hip and die. How does one balance low protein and sarcopenia? Reply David Leader David Leader 7 months ago Well done Reply Jim Jimmy Jim Jimmy 4 years ago Extremely interesting.Wrong about cancer not being a metabloic disease, I think, but I can hardly wait for the book. 1 Reply 1 reply rob28803 rob28803 2 years ago And I was worried about not getting enough protein on my low carb diet... 3 Reply 1 reply Ancestral Politics Ancestral Politics 3 years ago Interesting talk, great info. I do wonder sometimes if we are still putting the cart before the horse here, as the studies show that IGF-1 is linked to aging and cancer in some way, but nothing I've seen here really talks about the why or the how (I feel like I went through this with fat, cholesterol, and then LDL - demonizing things because we saw some correlative link instead understanding the causation behind it). We know that restricting serum IGF-1 artificially can lead to longer life, but that is again putting it under a microscope without understanding the full interaction here. For example, we know that IF brings down serum IGF-1 temporarily, but long-term calorie restriction doesn't bring down serum IGF-1 long-term - why is that? Amino acids coming in from outside in the graph shown at the 40:00 minute mark don't seem to go through some pathway that connects them to higher levels of IGF-1 or mTOR than with autophagy alone. So what is going on there? The only study in this video linking IGF-1 with protein was in people getting near 50% of their energy from carbs. Do the resultant insulin spikes from that kind of eating affect how much protein changes/controls IGF-1? Are there some amino acids that trigger it more than others? Does protein immediately after exercise direct IGF-1 and mTOR toward repair of the muscles, preventing cancer as long as autophagy can take place later? If protein is closely linked IGF-1 and IGF-1 is closely linked to inflammation, then why is my inflammation low on my high-protein diet? I don't understand quite a bit the why/how question yet. This video does a great job at showing the correlation between IGF-1, protein, and mortality - which needs to be looked at and studied. The problem is it doesn't show causation, which is always the piece that really determines the health part. That being said, if the science could show a clear causal link, I would definitely jump on board. 5 Reply 3 replies Siim Land Siim Land 5 years ago Crazy stuff - I believe you want to suppress mTOR for the majority of time and use it only for maintaining lean muscle mass at other times. Like the 80/20 or 90/10 rule 18 Reply 10 replies Anthony Danes Anthony Danes 4 years ago (edited) Wow I thought I had it all figured out...I guess I didn't. I guess he saved me money on food steaks and chicken ain't cheap. The Doctor made a strong case. 3 Reply obada A obada A 1 year ago How does fasting/calorie restriction increase longevity when it is known to boost HGH levels? I thought growth hormone is to be kept low for longevity Reply arcidiavolo arcidiavolo 5 years ago dr rosedale, the harder, the best 1 Reply liutasx liutasx 5 years ago Most cancer cells growth in environment lacking oxygen. This cause to secrete Hypoxia Induced Factor - 1 or for short (HIF1). One of HIP1 function is to cause cells use anaerobic respiration e.g. to produce lactic acid and in order to do that cancerous cells adjust metabolic pathways to use environment to their advantage, cells that don't adjust to this environment die off. Of course the more cells division is caused by growth factor, the bigger probability the bigger probability is to get malignant cells. 2 Reply Gayle Mcdonald Gayle Mcdonald 1 year ago I get that nature is done with our evolution after we replicate but I'm thinking that with the new found understanding of epigenetics, we are modifying our DNA (perhaps improving it to be passed on?) and may be a reason that we are living after replicating. Reply David N David N 5 years ago How old is Dr. Ron Rosedale? Someone on a site said he's 62 in 2012, so he's 67 now? He looks very good for a 67 year old (if it's true). 11 Reply 3 replies Todd Studer Todd Studer 5 years ago Would this mean that use of saunas or cold thermogenesis, both of which appear to increase growth hormone by large amounts, would promote cancer growth? 1 Reply 1 reply S L S L 1 year ago So many typical doctors dis his work with a superior attitude 1 Reply Tom Sawyer Tom Sawyer 3 years ago when I find someone who's that insisting against proteins (which by the way, never differenciates), I suspect a vegan, or an undercover vegan 😂 12 Reply 3 replies Michael Michael 4 years ago Well this is all very depressing since I have looked at research suggesting longevity is also associated with higher lean body mass and that people over 40 need double the amount of protein to maintain or increase it. I have embarked on a strength training high protein regime based on this. 10 Reply 5 replies Alex Peikary Alex Peikary 5 years ago Thank you. 2 Reply Mister Fox Mister Fox 3 years ago I would like a concise summary of what exactly he recommends a person eat in terms of protein, carbs, and fats. 4 Reply 4 replies Appleblade Appleblade 4 years ago Anybody see any reason you can't have high protein and high TOR but occasionally fast and do clean up for anti cancer anti ageing? I don't see anything in this talk prohibiting this. 7 Reply 2 replies David's TV David's TV 3 years ago 11:07 energy is used for 1 of 2 purposes. it takes a lot of energy to reproduce, also it takes lots of energy to repair. it has to decide, if there is enough nutrients, can support cellular replication. if there is are, then the genetic expression switch to reproduction/cellular replication. if there are not enough nutrients to support cellular replication, then the energy is invested in repair, so that that organism can outlive the perceived Nutrient Depravation, so that it can pass on the genome at a future more nutritional opportunity time. this is a decision that your body and your cell are making all the time. 1 Reply 1 reply Daniel Stapler Daniel Stapler 4 years ago 1:12 The Answer first : "Your health and your lifespan will likely be determined by the proportion fat versus sugar you burn over a lifetime" So he means excess protein is turned into sugar with bonus bad mTOR activation stuff added, I think ? What to do with this info? Maybe i'll just count my protein grams and be aware of how much i'm consuming and look for low or lower protein options. Coconut milk seems like a good item to include. 2 Reply 1 reply Doctor Ni Una Dieta Más Doctor Ni Una Dieta Más 5 years ago Whey (leucine) and meat (glutamine) have very different effect 9 Reply 6 replies Peter Cyr Peter Cyr 3 years ago The most important thing is to be a fat burner. We can argue about how much protein to eat. For instance people with extreme autoimmune issues seem to do better and get huge relief on carnivore diet. I guess eat as little protein as you can to promote as much autophogy as possible. 2 Reply 4 replies K K 2 years ago summary: restrict carbs of course but also protein to increase autophagy of crap cells. eat mostly healthy fat. 9 Reply 1 reply Luca Sichel Turco Luca Sichel Turco 4 years ago I am a bit at a loss. Following the advice to reduce to 0.75g/kg lean mass the protein intake (good but NOT optimum!) and assuming a low carb diet with 30g/day of carbs, I should get around 180g of fat, with around 50g of proteins and 30g of carbs. How can you eat like that if you don't want to gulp down oliv oil or eat butter by itself? What recipes have that type of ratio? 5 Reply 5 replies Tor Christian Stamnes Tor Christian Stamnes 2 years ago If you list the things mTor promotes in a positive way you could make the logic that we need as much as possible of it. You need it in a balanced way. Amino acids are essential. 1 Reply 1 reply Ursula Reeber-Isariuk Ursula Reeber-Isariuk 2 years ago What protein? Gluten? 1 Reply Billy97 Billy97 3 years ago (edited) The .75g/kg is not far from what I eat on my keto/carni eating , now that I am eating less, omad. We should remember also that humans are not mice. To say that this is all solid science is going a bit far. I am no expert but it is easy to see that humans are capable of functioning for a long time on a wide range of nutrients. Getting down to two decimal places based on mice is hubris. Can we see the calculations that arrived at that figure? And the underlying source data? How do we know that it is not 0.773g/kg/day? We know now that the public health dietary DV guidelines are rectally sourced. I just heard about a woman who has consumed .5kg of sugar per day in pepsi alone for all of her life. Not she is 60 and has to cut down to 4 cans after heart attack and diabetic shock. Stunning. Still alive. 3 Reply 2 replies Itzak Ehrenberg Itzak Ehrenberg 1 year ago So it's to be LCLPHF diets from now on? Reply Luca Luca 5 years ago Yes but we cannot completely eliminate aminoacids in the diet and for muscle growth it is essential to stimulate mTOR because we need to eat relatively high amount of proteins. Reply Razvan Florentin Popescu Razvan Florentin Popescu 5 years ago (edited) bottom line is 1 insulin management > keto ? 2 protein management ? to what amount ? doing it 1 week a month? 1 moth a year ? throw a suggestion mate Reply 3 replies JB Fitness JB Fitness 4 years ago (edited) 0.6g of protein per kg... that puts me at 48.6g hmmm that is definitely low - I wonder how this mixes with muscle building. But I guess you can't because this presentation is about anti-growth for health and cancer prevention... while muscle building is pro-growth, so doing the exact opposite. Hmmm pick your path 🤔 9 Reply 7 replies Keskinkilicnr1 Keskinkilicnr1 3 years ago to be honest I expected a little bit more informations. It is a little bit confusing. He explains that protein increases mTor and says that is crucial to reduce protein and by the way tells that ketones feeds some cancer too. This makes the impression that you now can eat carbs and then along the video he says, " I am not saying not only resrict protein but carbs, too.....ok and what's left?....and at the very end he tells you can eat fat. Ok....... 2 Reply 3 replies Tony Morse Tony Morse 7 months ago How much Protein is too much..?? Reply 1 reply LIVIN CINCY LIVIN CINCY 1 year ago The low Protein hypothesis has changed since he expressed his concerns about protein being associated with cancer. 1 Reply 1 reply Robis9267 Robis9267 5 years ago Does this makes vegan diets better for long term survival? Reply 3 replies Stuart Branson - Theme Composer Stuart Branson - Theme Composer 4 years ago So what's left to eat, coconut oil and butter ? 12 Reply 7 replies Young MGTOW Young MGTOW 5 years ago So according to this LC is pretty much useless. Since everything comes down to TOR. A low protein , high carb diet should work. Even though you said :"You still have to restrict carbs". But What is the point of low carb ? Reply 12 replies saikatghosh90 saikatghosh90 1 year ago plant protein increases and animal protein decreases longevity 2 Reply 1 reply Parker Baumann Parker Baumann 7 months ago This guy is just wrong about the genetic theory of cancer being incorrect. Anybody with a basic understanding of cancer knows that cancer is primarily driven by mutations in oncogenes which trigger replication and tumor suppressor genes which act as breaks to halt it if something goes wrong. Those are the first two genes get altered and trigger cancer and as cancer continues more and more mutations occur as the machinery to repair errors gets eroded and that's why genetic profiles of cancer are so different. It doesn't matter if individual cell profiles are different if the primary driver is the same and can be targeted with genetic healthcare. This guy completely glosses over such a basic detail to push his shitty diet. Guy must is either lying or incompetent Reply goldwingnut1954 goldwingnut1954 4 years ago I don't have enough faith to believe in this type of evolution, no matter HOW MANY bazillions of years you add on. I much more readily track with the Traditional Creationist Model. Other than that, this guy seems to know his stuff. 2 Reply 1 reply David DiRusso David DiRusso 1 year ago How does this work in animals that are obligate carnivores? 1 Reply 1 reply Albert Glover Albert Glover 2 years ago I would like to know where does dr Rosedale get it that insulin is about 500 million years old. It is easy just to make up a story. Like his evolutionary story. Too many medical talks jump on the evolutionary history story just stating it as a fact. It makes me wander about the rest of their science. The hunter gathered narrative. It is so rive. Really do we have to listen it. 3 Reply Fanur Anuojat Fanur Anuojat 5 years ago Correct if i am wrong but isint exercise, one thing we do know to be very healthy for you body and brain function, triggering mTOR significantly? 3 Reply 5 replies Stephen Mayo Stephen Mayo 2 years ago So. No carbs; No protein. No animal products? Just fat?! I am completely confused. What does that look like in practice? 3 Reply 4 replies Kathy A Kathy A 1 year ago But most people eat low protein. Reply 1 reply J J 1 year ago (edited) Great info but got to stop the lip smacking. Reply Ben Holland Ben Holland 5 years ago Might has well throw my fat for fuel by dr mercola away!!! I'm so confused !!!!! 3 Reply 4 replies B R B R 2 years ago The Alistair McClean of health but not sure I believe him. He thinks seed oils are good because they are "fats" - but no no - oxidative stress aging promoters 2 Reply P Wilki P Wilki 5 years ago Made it 30 seconds.... Reply stufen11 stufen11 2 years ago Evolution is just an edumacated guess. The science is definitely not "in". And protein, don't get me started. What a crock. A likeable guy though . 1 Reply Razvan Florentin Popescu Razvan Florentin Popescu 5 years ago people who disliked, id like to hear arguments , you seem to have some important information to dislike this , make it public ffs 7 Reply 5 replies Happyapple42 Happyapple42 1 year ago Just eat the cow , When hungry. Reply John Vatistas John Vatistas 2 years ago interesting but try not walking and turning so much. it's so distracting. 2 Reply 1 reply Robert Yang Robert Yang 4 years ago Geraldo Rivera? 3 Reply SciSci SciSci 2 years ago (edited) Nature doesnt really care, we start dying once we have started spreading our seed for the nest generation of humans, your role is over and you are not needed anymore and so rapid aging starts. If Im not mistaken oxidative stress is good as it can control Cancer but ages you at the same time, how can we balance this, keep it around to control any cancer growth and yet avoid aging? if you reduce oxidative stress, via the NRf2 pathway which is activated via Hormetic activity like cold exposure, sauna etc or eating Turmeric, Sulforaphane etc but excess in Nrf2 pathway has been implicated in Cancer growth and proliferation, whats the solution to this? Thankyou ps I just heard him say Oxidative stress and the theory of aging could be incorrect :/ Why not eat meat once a day or only twice this will stimulate TOR only twice for short periods of time and the rest of the time you fast or even OMAD on a vegan type diet, sure insulin will surge but not for the whole day, then you can easily calorie restrict, low IGF1, low AGE's, and one surge of insulin, done. Reply 2 replies Folke Olofsson Folke Olofsson 1 year ago Altogether evolutionarily irrational, this smells more like disinfo. Consciously or not. 1 Reply liutasx liutasx 5 years ago Cancer is genetic disease, that cause mutation is another talk. Cancer have driven mutation like disabling apoptosis, self-sufficient grow factor and 5 more. Other mutations in tumor mass is due microenvironment e.g. oxygen, nutrient availability. Reply Hélène Drouin Hélène Drouin 1 year ago Are animal and vegetal proteins equal to him? Dr Campbell sais no: animal protein favors cancer growth, while vege protein have no deleterious effect Reply 1 reply Black and Pink Panda Black and Pink Panda 5 years ago You lost me at evolution 15 Reply 5 replies schooledamerica schooledamerica 4 years ago OK, enough with the evolution stuff. That literally validates zilch in terms of the why's. After all God, is perfectly capable of designing His creation anyway He wants. Tip number two...is it just me or is the mouth spit hard to hear? Just some constructive criticism. Very smart guy tho.... Reply 1 reply 1pedalsteel 1pedalsteel 3 years ago All conjecture based on a simplistic view of a theory of evolution that itself is little more than an educated guess. Self delusion begets hubris. Reply 2 replies