aging david sinclair Sep 22, 2020 , Plus: NMN update

#davidsinclair #aging #livelonger Aging: Your DNA Is Not Your Destiny Ft. David Sinclair (Full Event) | Think Inc. Think Inc. 11.5K subscribers Subscribe 901 Share 23,303 views Premiered Sep 22, 2020 Your DNA is not your destiny, and aging doesn’t need to be an eventuality we begrudgingly accept. We can get in front of it, control it; steer the ship towards death rather than be led by the hand. Subscribe to Think Inc. → http://bit.ly/33tJYEN For most of us, the end of our lives will come with the long and drawn out prelude of old age. It’s a process that we all accept is going to suck, with our bodies and minds slowly failing us, and eventually taking away our independence. In the past, this grim reality was the perfect pitch for snake-oil salesmen peddling miracle elixirs that promised a long life with great health. Today, those peddlers still exist, setting up shop on the internet, sadly drawing in crowds of desperate people with click-bait titles and fake testimonials. But that dream of a pill or tonic that reverses the effects of aging is still worth pursuing, right? Science has opened the doors to dramatically increased life expectancies, the curing and management of fatal diseases – we even put a MAN ON THE MOON! So, why is it crazy to think we can find a solution to aging? Professor David Sinclair thinks it’s far from madness. In fact, he’s been researching it for years and has uncovered potentially viable methods of managing old age. He's here to show you that “if we studied aging as a disease in its own right, and really sought to understand its mechanics, we could not only treat it, but beat it. All of us could live to be 150 and die gracefully.” This video comes from our Outside The Box event series - live online events that feature prolific speakers whose ideas will challenge and change the way you see the world. Find out more at https://thinkinc.org.au/events/outsid... ABOUT THINK INC. Think Inc. is a community of individuals on a mission to expose the true face of modern society. Armed with ideas, we defy the stale conventions of learning by shifting the world’s attention to global ideas, while opening minds. We’re not on the fringe. We are trendsetters with the power to shift perceptions and reshape the face of the mainstream. In 2014, Think Inc. launched with the mandate of creating a community where ideas can be shared, challenged, voiced and became a champion of democratising ideas. On this foundation, Think Inc. has grown into a powerful collective. CONNECT WITH US Join our mailing list → http://bit.ly/think-sign-up Check out our store → http://bit.ly/ao-think-store Website: https://thinkinc.org.au/ Facebook: https://www.facebook.com/ThinkInc.org... Twitter: https://twitter.com/thinkincAU Instagram: https://www.instagram.com/thinkinc/ LinkedIn: https://au.linkedin.com/company/think... #davidsinclair #aging #livelonger Key moments View all 82 Comments rongmaw lin Add a comment... jazzispirit jazzispirit 1 year ago Genetics loads the gun..lifestyle pulls the trigger. My mom lived till 104, I’m 84, still hiking with my daughters, feel grateful and blessed. Not the greatest knees, lol, due to a slip and fall, but use the hiking sticks, which works. Love Dr Sinclair’s work and book. Wishing everyone the best of health! 9 Reply Jan Hooper Jan Hooper 2 years ago Thank you Dr. Sinclair! I’ve read your book and watched as many of your videos I can find. This one is particularly detailed and helpful. Makes me feel I actually understand, at least conceptually, how NMN may keep me healthy longer. Gives me HOPE! 1 Reply Sherrie C Sherrie C 1 year ago Yes David it should be treated as a disease and doctors be able to treat us for it. Thank you for the info and your time. So thankful for your work. 1 Reply farzana khan farzana khan 2 years ago I love the work that you are doing Prof David Sinclair. I wish the world would be mote open to this kind of research & encourage you forward. Being a medical doctor first and holding a master’s degree in Healthy Aging makes me even more interested in this kind of research & I for sure would love to be a member of this group for sure..!!! Reply Sherif Elkahky Sherif Elkahky 2 years ago Amazing interview. The best I have seen for Prof. David Sinclair so far. 6 Reply Miriam Chamorro Miriam Chamorro 2 years ago Yes I consider aging a desease I’m 68 look much younger and feel like 12 years old ... All my life I took care on what to eat and exercise ...I’m Belgium descendent Born in Paraguay South America . Only ate when feeling hungry healthy vegetables green tea from Paraguay No wheat ... (turned out to be gluten intolerant ) So from 5 years old did not eat bread it made me feel bad , stomach gastric acidity.. so I didn’t eat it )... now I feel like 12 and I am 68 years old ... I started to grow some gray hair after this Pandemic DUE TO HIGH STRESS ... like everyone else ... IF I CAN HELP OR CONTRIBUTE IN ANY WAY TO YOUR STUDIES PLEASE COUNT ON ME ... Oh and started to drink red wine 🍷 when I was 49 ... All my life walked and ran for I hour in city woods (parks ) huge ones CONGRATS DR FOR YOUR EXCELLENT CONTRIBUTION 14 Reply Modern Healthspan Modern Healthspan 2 years ago Brilliant interview. My wife and I are following Dr. Sinclair's works. I'm closed to 60's and started taking NMN last year and got amazing results. We started record our anti-journey in our channel hope to spread out the message of Aging is treatable and the importance of extending healthspan. It's never too late to start. 13 Reply 6 replies Aleksandras Sivkovas Aleksandras Sivkovas 2 years ago I remember my teacher saying we born 100 years too early to be able not to age 4 Reply Debasish Borthakur Debasish Borthakur 3 months ago (edited) We all must consider aging as a disease..😠 We all must support Dr. David Sinclair and all other Scientists around the world who are trying really hard to reverse the aging process in humans.. This is a really interesting stuff going on all over the world..👍 Love from India..🙏 1 Reply Shirleen Frailich Shirleen Frailich 2 years ago David this presentation is great especially the part about the silliness (or perhaps better word nastiness) of academic medicine. In our view, to really address aging academic medicine is essentially obsolete. The fact that the TAME study with Nir took ~4 years to get going says it all. So you know, we are older than you. In our view, your eye program has potentially very serious flaws wherein your actual thesis is correct but will fail after years of work. With this said we’d like to connect with you. We are a big fan of what you are doing—to be clear. However discretion is important as you know. Reply 守lower 守lower 2 years ago David Thank you so much for everything you are doing for all of us, a question I have is, If you can reverse your age does that mean hair grows back and grey hait turms brown again ? Like we are obviously used to being impossible. I suppose at the time your test age was so much higher and you tried these drugs your hair was brown and the way it is today. I've been very ill a lot and I have lost my hair and it's grey , I feel very unfairly treated by life for that reason (Just being honest) but offcourse I want to move forward in life, Many Thanks >< Reply mimilili99 mimilili99 2 years ago Wow! Thank you so much for sharing this! Could someone with paralysis benefit from the Yamanaka? I don't know about ethics and laws but think any human with nerve damage wouldn't mind being voluntary for that? 1 Reply 2 replies Sadonte Johnson Sadonte Johnson 1 year ago Man I can't wait for 5 years anti aging so I don't have to be a adult Reply Carl White Carl White 2 years ago Funding should really be poured in to accelerate both the research and the clinical trials. We're all on the clock. 3 Reply Povijest Povijest Povijest Povijest 2 years ago While his analogy with Wright brothers might be true, imagine if every time we made a major breakthrough in aviation, the brothers got rejuvenated by 20, 30 or 40 years. Would they be able to live long enough to see humanity reaching another solar system? Maybe. Just because immortality might be centuries away, it doesn't mean we won't live long enough to reach it. 4 Reply Dan Dan 2 years ago (edited) I hope that in 20-30 years we will see the advent of cellular engineering, first of all gradually eliminating and reversing the aging factors. Eventually, we will be able to reverse and stabilize human biology at ~20 years old, perhaps completely so in 50 years from now. Although I feel current improvements are minor, I think that Dr. Sinclair is establishing some groundwork on that. Eventually we will have to revise social norms and regulations as this transitions to full genetic and epigenetic engineering at a cell-by-cell level in mature organisms. Perhaps in 100 years from now, it will start to mix with synthetic life components (which will be nothing like we understand by hardware nowadays). Natural evolution is a cruel mistress with random actions and incapable of fundamental redesign, it is a certainty that we shall have to supplant it (as without the cruel 2 out of 3 death rate from natural selection, current society would eventually and inevitably lead to genome degradation across the entire species). 1 Reply Rita Hall Rita Hall 2 years ago Aging is a medical condition but western doctors will not be open to such radical concepts I’m sure of it yet I’m very excited about this science and the future of health care 1 Reply Alex Manga Alex Manga 2 years ago Treated, it is a disease sorry I can not help comment,you do great work and thank you. Reply j simon j simon 2 years ago its like rna forgot to remember how looks like as a young person. 2 Reply William James William James 2 years ago I think it should be treated as disease. I also think that if you were to out line a program of supplements & eating etc, you could get thousands to follow & possibly get some usable data for the benefit of us all....I'm 78, & therefore probable more interested in get some solutions earlier than a younger person who is willing to wait. Reply The V Countdown The V Countdown 2 years ago This man looks younger than a couple of months ago. Thats crazy. Reply 2 replies Sleep Smart Smash Stress Sleep Smart Smash Stress 2 years ago May I insert a caveat style amendment for the audience that to an extent it is wrong to call or view the as opposed to the nerves that run in the legs and arms etc., the cranial nerve no 1 (olfactory) and no 2 (optic) are not true peripheral nerves or central nervous system extensions and can be and should be seen as spinal cord type central nervous system tissue which vehemently resist repair and restoration in axonal damage, (MS type damages to CNS recovers due to its being limited to the myelin sheath). Therefore if there is regeneration of the first two (so called) cranial nerves then you are accomplishing a higher level outcome as opposed to the regular cranial or peripheral nerves which are well known to repair themselves spontaneously e.g. facial nerver palsies routinely recover. Reply mercadinho do Vizinho mercadinho do Vizinho 2 years ago OFF COURSE,THE AGING IS DESEASE... 1 Reply donrayjay donrayjay 1 year ago Feel sorry for the mice with crushed optical nerves 😞 2 Reply john Grosser john Grosser 1 year ago It's a disease but can be slowed down with healthy living exercise live food avoid depression stay happy but it's very difficult. Reply Brad Hughes Brad Hughes 2 years ago Yes, it should be treated as a reverseable process. Reply Shay Raecok Shay Raecok 2 years ago reduce Aminos? So no proteine ? What should I eat then? Reply Samuel Aguilar Samuel Aguilar 3 months ago 60/100 is possible Reply joseph lozoponi joseph lozoponi 2 years ago All the companies are price gouging with NMN 9 Reply TimBo TimBo 1 year ago Aging is a disease that is no different than other ongoing treatable diseases like diabetes or other chronic conditions. 1 Reply joseph lozoponi joseph lozoponi 2 years ago Will NADH do what NMN does. Reply Minerva Aldape Minerva Aldape 2 years ago Can you cured insomnia with fasting? Reply 3 replies Deborah Behr Deborah Behr 1 year ago Please send me some Metformin. Reply Steven Lucks Steven Lucks 1 year ago As a Lifestyle Medicine Practitioner yes aging is a disease, regular doctors no 👎 Reply Steven Lucks Steven Lucks 1 year ago Why do some say that NMN is cancer Reply Alex Manga Alex Manga 2 years ago Help me with my dad he has lung cancer please. Reply Conversas Controversas Conversas Controversas 2 years ago Its really possible reverse age? Reply 2 replies TEM 14 TEM 14 2 years ago Is there even an answer to any of those questions??? It's one of those easy questions with literally no answer to. Reply 守lower 守lower 2 years ago People should not be concerned about population growth. People in poor conditions have many more children than people who are well off, as you can see by where most people on earth live and this a natural mechanism so when people are enjoying peace and health they will have less children, Sinclair is right it will level off 1 Reply 2 replies Minerva Aldape Minerva Aldape 2 years ago Yes .enbejeseser debe tratarse como una enfermedad y debe tratarese medicaments. Insomio es parte de enbejeser se puede tratar o curar con ayuno? 1 Reply 1 reply Cyberbronco Cyberbronco 2 years ago Where did this originally appear? Reply 1 reply Debasish Borthakur Debasish Borthakur 3 months ago Can CRISPR-CAS9 TECHNOLOGY help build muscles in old peoples??.. 1 Reply joseph lozoponi joseph lozoponi 2 years ago can i take NADH instead of NMN . i cant afford NMN. NADH is cheaper Reply 6 replies CruiseFit CruiseFit 2 years ago No white hairs at 50? Reply Amanda Amanda 1 month ago Why is everyone's name Steve? Reply Vicky Biagini Vicky Biagini 2 years ago This man looks 50, Comeon 1 David Sinclair Response To NMN Ban - Analysis The Pulse 5,119 views Dec 17, 2022 #nmn #davidsinclair #longevity David Sinclair has responded to the FDA and their attempt to remove NMN as a dietary supplement. In this video I discuss each portion of David's letter and breakdown my reaction to his message. This channel focuses on scientific advances spearheaded by Dr. David Sinclair at Harvard and others leading the world in anti-aging research. Subscribe and join me on this journey. Here are the links to DoNotAge where you can save on the supplements I'm taking. For DoNotAge use code "THEPULSE" to save 10% (can be used on multiple orders) (Fisetin) https://donotage.org/products/pure-fi... (NMN powder) https://donotage.org/products/pure-nm... (NMN capsules) https://donotage.org/products/pure-nm... (Resveratrol powder) https://donotage.org/products/pure-re... (Resveratrol capsules) https://donotage.org/products/pure-re... (TMG) https://donotage.org/products/pure-tmg/ (CA-AKGK) https://donotage.org/products/calcium... (Sirt6 Activator) https://donotage.org/products/sirtuin... (Hyaluronic Acid) https://donotage.org/products/pure-hy... (Sulforaboost) https://donotage.org/products/sulfora... (Spermidine) https://donotage.org/products/spermid... (DoNotAge Subscription) http://www.donotage.org/subscribe/ I recently worked out an agreement with a health levels home blood testing company and a 25% discount for my viewers. I receive commissions for referrals to LetsGetChecked.com Use this customer link https://trylgc.com/thepulse And enter code PULSE25 to save 25% of any of their test packages. This is my new Patreon page. I appreciate your support.https://www.patreon.com/marcelthepulse Join this new Facebook Group where we can discuss all of this https://www.facebook.com/groups/57107... _______contents of video__________________ 00:00 - Intro 01:42 - Sinclair Shifts Discussion To NMN Safety 04:24 - Sinclair Claims He's Not Benefited From NMN 05:15 - Sinclair Distances Himself From Metro Biotech 06:30 - Sinclair Says Substances In Trials Can't Remain Supplements 07:28 - Sinclair Suggests Only Drugs Can Treat Diseases 08:38 - Sinclair Spreads Pro FDA Propaganda 09:53 - Sinclair Compares NMN To NAC Being Exempt From Ban 14:14 - Sinclair Stops Referring To NMN As MIB-626 #nmn #davidsinclair #longevity #mitochondria #podcast #health #lifespan #supplements #resveratrol #nad #lookyounger #donotage #antiaging #reverseaging Disclaimer: The Content has been made available for informational and educational purposes only. The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. The creator hereby disclaims any and all liability to any party for any direct, indirect, implied, punitive, special, incidental or other consequential damages arising directly or indirectly from any use of the Content, which is provided as is, and without warranties. Chapters View all 168 Comments rongmaw lin Add a comment... Jay Stuart Jay Stuart 1 day ago Lots of great info in this one. Thank you for your contribution to this subject matter and the supplement industry as a whole! 10 The Pulse Reply The Pulse · 1 reply Dawn Whitehead Dawn Whitehead 1 day ago Thanks, Marcel, for your take on the scuttlebutt around this topic. Appreciated as always. For myself, I continue to ingest NMN, TMG and resveratrol and continue to experience benefits that I was not getting from other supplements. At my age 79.5, I am definitely impressed with changes I have experienced over the past 8 months of NMN use. I still continue with my others from The Life Extension Foundation which I have been using over the past 40+ years! Those include vitamins C, D3, K2, Bcomplex, magnesium, fisetin, lithium, quercetin, melatonin and a few others. The changes are definitely age-related and are backing off, little by little. I would not want to go back and have no plans to do so. Thanks again! ❤️🎄🎅🎁❤️ 9 Reply The Pulse · 2 replies EMH EMH 4 hours ago (edited) I'm impressed with the NMN results I've seen in my dad (age 83). He has multiple chronic conditions, chronic kidney failure (stage 1 now, was stage 3), chronic heart failure (various improved markers), and vascular dementia. This is an unqualifiable observed improvement in memory and cognition, and incontinence. At the risk of being blunt, basically he's not peeing and pooping his pants or his bed anymore (This is huge). However, dad is taking 2.4g per day (huge dose based on mouse studies). We started at a lower doses for 12 months @600 mg per day. We saw no meaningful improvement, and then went higher after a stroke. At this new higher dose dramatic improvements were observed after 16 weeks. He also takes 2g of TMG. It seems that David Sinclair is trying to profit from this. 1 Reply Elliott Rubenstein Elliott Rubenstein 1 day ago Thank you Mr M for a brilliant analysis and one I agree with. 9 Reply Candra D Candra D 22 hours ago Thank you Marcel for explaining this in a way which even the simplest minds like mine,can understand! 2 Reply Brian Le Breton Brian Le Breton 16 hours ago Thank you Marcel! Great review and analysis of the letter. It is sad that there’s doesn’t seem to be an easy way back for David Sinclair to return to being seen as defender of the people. His work so far has brought so much hope and now it’s overshadowed by this business decision that pits peoples desire for health against his company’s ability to make money whether it be for future research or simply pure profit. As a supplement, it still makes money for many but not the people and businesses that are used to making money through monopolization. I think there’s a big difference in making a product that people “can’t live without” (as a new convenience that can increase productivity) and patenting it for profit and making a product that constitutes a fundamental cure for a human disease that people will die without. Not sure if the laws make that moral distinction. Reply Jos van der Spek Jos van der Spek 19 hours ago Thanks for this great clarification! This is what I (and undoubtedly many others) have been waiting for! 1 Reply Martin Von WunderGass Martin Von WunderGass 15 hours ago That's interesting you mentioned CBD at 12:07 because I've been thinking of this supplement lately, of how many benefits it has on human physiology, and what would be the effect of taking NMN combined with CBD. I've not yet tried both, but this is something I'll get around to in the near future. Reply helen helen 1 day ago We also need to remember that Sinclair's stated deeper mission has always been to achieve medical recognition of AGING AS A DISEASE. Unless that motive is no longer part of his long-term mission. This may be a necessary step in his strategic plan. 4 Reply 4 replies Robert Kuiper Robert Kuiper 1 day ago Thanks Marcel, appreciate your continued integrity! 8 Reply Keto with JT Keto with JT 1 day ago Love your content Marcel. I appreciate your thoughtful review and commentary of this letter. Agreed. 3 Reply The Pulse · 2 replies stephanie stephanie 17 hours ago I think he knows he’s lost the battle for exclusivity, and now he’s trying to save face with this statement. I think they’ve advised him, the best he can hope for is that it will be available both as a supplement and by prescription, which is in the best interest of the public as it’s unrestricted but can also be covered by insurance. David Sinclair has always been clear that it’s his goal to create a prescription drug to reverse aging. Ironically, a most recent video collab of his with Serena Poon, features a skin formula he designed, and is now promoting with the seedy showmanship of the Home Shopping Network. 1 Reply donald drechsler donald drechsler 1 day ago Nice job on explaining what is happening with NMN. Like you I am taking NMN on Dr. Sinclair explanation on how well it works. 3 Reply Tim Harrison Tim Harrison 1 day ago It’s a very carefully worded letter and warrants a careful reading, as you have shown. I appreciate your perspective and thoughts on this. The emphasis on “FDA is good” appears to be the intended primary takeaway. The reasons are still unknown. There are definitely forces at play, and it’s certainly easy to start blaming David Sinclair as a greedy antagonist. Maybe that’s true. I don’t know. But also I don’t need to make a judgement on him. What matters to me is whether NMN works as we all hope it does. So that’s the lens I’m looking through. Drama is exciting. But longevity and healthy are my only priorities. Thanks for the video. 6 Reply The Pulse · 2 replies Anna O'Leary Anna O'Leary 1 day ago Marcel, a big thank ypu for keeping us up to date on the intention of the few to profit from NMN. Every man has a price. David sold out pretty rapidly. I question Harvard because of huge funding from big pharma. Together we will fight them as we did over withdrawal of NAC. I'm in my 70s and you couldn't get me to take a drug but i am huge into supplements, clean spring water and home cooked food. Right now i have near zero respect for doctors who sell their souls and the welfare of the of their patients for the big pharma and WEF rewards. 🏡 1 Reply David Jordan David Jordan 1 day ago (edited) Like Marcel, I am optimistic (cautiously in my case) that NMN will remain sellable and available. Part of this is the certainty that.the US supplement industry will communicate with the FDA on the issue (indeed, one other presenter right here on YT, Brad Stanfield, IIRC, states they have already begun the discussions) and may bring suit against the FDA, if necessary). Part of the industry's logic is the documentable fact that NMN has been sold long before Metro Biotech began their studies of NMN, or some derivative, as a patentable drug. We'll see. 2 Reply jana Peony jana Peony 1 day ago Thanks again Marcel,you make so much sence ,looking forward for your vids ,always. 2 Reply Sam Adams Sam Adams 1 day ago It is also clear that Sinclair continued to push Resveratrol to help preserve his reputation long after it was found to be nearly useless. He is clearly a self interested investor more than he is a researcher. I think he imagines himself becoming the Elon Musk of the longevity biotechs. This is no surprise to me - he's always seemed to me to be hyping unproven treatments. This is not something you see any other major researcher doing. 4 Reply C-Stance C-Stance C-Stance C-Stance 1 day ago On Instagram there was also a reaction from people who stopped taking NMN and suddenly experiencing some rapid ageing afterwards! Have you seen this? It looks sort of worrying.. I never heard anyone using NMN commenting this before. What are your thoughts about this? Did you hear of this before? Or anybody of the followers here? I’d like to know! 4 Reply 5 replies PJTV PJTV 1 day ago He is the ultimate gaslighter. If he had nothing to do with this and was against it considering he is part owner of the actual patent for this MIB stuff he had control over what happened to his patent lol. He would have spoken up immediately and loudly if he was against what was happening and would have exercised his rights as a patent holder. As I said in the beginning there were choices he could have made and he chose this path. He did not choose the path that was chosen for NR he chose the other path and yes HE chose it otherwise it would not be happening. I am happy for his work in the field as I am with others however you cannot deny that he is also as slimey as they come. As for their new improved NMN I question whether its truly any different then the uthever that most supplement companies sell. (i'm suspicious of that as well in fact I wonder if its the same thing ... ) 14 Reply Arthur Lee Arthur Lee 1 day ago This situation reminds me of Amarin trying to turn fish oil into a drug. 4 Reply Andrew Last Andrew Last 1 day ago Great content. I've just started taking nmn and look forward to seeing your video on fakes. 1 Reply Evan Fortag Evan Fortag 1 day ago Hey Marcel, question about NMN side effects. Me and my wife recently started NMN + Resveratrol at 500mg NMN + 1g Res upon waking. The first night we both had insomnia and for the following three days had pretty pronounced side effects. These included but were not limited too insomnia, dehydration, poor memory, bright urine, allergies, lethargy. My best guess is that this is caused by undermethylation and the immediate loss of all of our B-vitamins. I believe the fix could be adding TMG at some dose. I’ve read a lot of people having similar symptoms on forums. Could you shed some light on this if only anecdotally? 1 Reply 2 replies Mike Ghafoori Mike Ghafoori 1 day ago Thank you for a great explanation 2 Reply natalie cavalli natalie cavalli 1 day ago Thank you for this update! 1 Reply Jim Bob Jim Bob 21 hours ago I’ve seen your before after pictures which are pretty dramatic. Would you be able to share what you weighed before/after. I’m just curious. You look great , you look really healthy. 2 Reply Dan Dan 1 day ago (edited) Because of the fake NMN it should be thoroughly regulated. However, we need to have access to it in the meantime. Worst case scenario, we'll be able to use NR or Niacin for a few years, don't know how well it will work for me, if as well as NMN. 1 Reply GYMPHO GYMPHO 1 day ago I started this video wanting to be against you, but after listening…(like many don’t, who make rude comments)…I agree with you! Great video 1 Reply Charles Coutret Charles Coutret 1 day ago I think that bringing all the David Sinclair worship to an end is the best thing that can happen to the NMN community. 8 Reply Digital Buzz Digital Buzz 1 day ago I looked up lab tests they could cost up to $5000 where do you do your lab test at an affordable amount? 2 Reply Pakistanicecream Pakistanicecream 1 day ago To check whether a medicinal intervention works or not, you can use a dynamometer to measure your hand grip strength. Do an internet search for an article by a blogger named 'marksdailyapple' with the title '10 Interesting Predictors of Longevity'. For some reason, my previous similar comment is getting automatically removed. 1 Reply wscheff wscheff 1 day ago Marcel... How did you know you were taking a fake NMN? Was it the way you felt... What were the indicators? 1 Reply The Pulse · 1 reply Connie H Connie H 1 day ago Thanks for the update. 1 Reply C-Stance C-Stance C-Stance C-Stance 1 day ago And I agree it took 6 weeks for the advocate of NMN to response 😢 If your show horse would have been put down you’d be on the defensive side? In the famous words of Sherlock Holmes.. The curious accident, of the dog that didn’t bark 😢 Reply James Lovell James Lovell 1 day ago He works for Harvard. I'm not surprised. 2 Reply Jax Obsessed Jax Obsessed 6 hours ago Hello Marcell. Thank you for your channel, I have learned a great deal from you. My only point other than that is if you expect a republican house to even consider changing laws that go against big pharma in favor of the common person's needs. Republicans will not ever do anything to help the citizens of the US as a whole. Reply The Pulse · 2 replies DixieGeezer DixieGeezer 1 day ago I'm done with Sinclair. Who's paying for his research? Who pays his salary? Is he, in a sense giving you a special flashlight, (Information on a Long Life) then selling you the special batteries, (NMN and others) at a high cost? 4 Reply Sharif Al Humaid Sharif Al Humaid 10 hours ago He's repeating the original message, and reinforcing his ownership. 1 Reply ZingPulse ZingPulse 44 minutes ago Natural Factors has just come out with a NMN supplement - RegenerLife MNM Surge. Reply Charlene Causey Charlene Causey 1 day ago What is your opinion of the brand Verso, NMN supplement with Resveratrol? Reply Diana Mayfield Diana Mayfield 1 day ago (edited) I will be giving David Sinclair the benefit of the doubt. Yes, he is a co-founder of a company that could possibly benefit from the huge profits gained by their version of NMN, but #1 - that doesn't mean that he has a controlling interest, does it? Could be, we don't know. 2. When Resveratrol was attacked, he personally was attacked and it took years for him to regain his reputation. I can just imagine that this slowed reaction could be his caution from being burned before. 3. If you have been following his interviews and postings for the past year, you should note a more insistent cry for research funds to cover the huge expense of the work he does. Harvard gives him housing, not necessarily monies to pay for this research. This mostly, as I understand it, comes from private (very wealthy) individuals and corporations, and it appears with the financial instability of the entire world, these funds are drying up - rapidly. His lab needs money. Rather than judging the man and speculating what all this means, I, for one, will wait to see what happens. Meanwhile, I will continue to keep a full year's supply of NMN in my fridge... 4 Reply milycome milycome 1 day ago (edited) Let's be accurate. There is a two tier system where a certain substance can be both a supplement (usually much cheaper) and a drug (usually much more expensive). Case in point : NAC is both a very moderately priced supplement and a drug (more expensive) used in hospital emergency rooms to treat Tylenol overdose toxicity to the liver. Both co-exist. Question, of course, can be asked : why pay more for the same chemical ?? Another example is fish oil EPA and the drug Vascepa. Some would say these two products are Not the same. Vascepa has been chemically twerked to be slightly different, but the net result really is a higher concentration of EPA and that the same EPA amounts can be achieved at a cheaper cost with supplemental over the counter fish oil, so again, why pay more ?? Answer : to protect the interests of the pharmacistical industry, Not the general interests of the masses (the public). Look at it this way : it's an example of the tyranny of the MINORITY. Not the MAJORITY, NO. The tyranny of the MINORITY !! 1 Reply Shelly Albaum Shelly Albaum 18 hours ago Happily, NR (Nicotinamide Riboside) works as well NMN, and it works the same way, and it won’t be taken off the market. Reply Virginia Ferrarini Virginia Ferrarini 13 hours ago Marcel, After this perhaps we should think again about resveratrol, do you agree? Thanks Reply gabymalembe gabymalembe 13 hours ago Since (judging by the comments on Amazon) the people who take NMN brands (brands that have littl or no NMN in them) report roughly the same benefits that people who take actual NMN, hopefully they won’t ban fake NMN. Reply The Pulse · 2 replies Bonnie Bonnie 17 hours ago I feel so much better on NMN from Donotage. He wants to make money with his own company. If I have to stop NMN I will be furious with Sinclair. The FDA is not infallible for that matter. I smell a rat. Reply TheONLYMayz TheONLYMayz 1 day ago I see what you’re doin there lol Reply amperez amperez 1 day ago Sad. I thought David was an honest guy, but apparently he is greedy. I currently take a NMN/Reservatrol formula and the thought of it being discontinued because it contains NMN is disturbing. I am new to this but I rescently discovered that Lipsomal NAD+ is available. It’s advantage is that no precursors are necessary, the NAD+ is highly absorbant, with a liposomal container that is easily delivered to the cell. 1 Reply 2 replies White Ninja White Ninja 1 day ago Watch that Sin Clair now. He not only looks like a ninja turtle--he IS one. 1 Reply Rebekka Hay Rebekka Hay 1 day ago (edited) That was very informative and thoughtful. I don’t doubt his research but his personality and intentions. In interviews he is simultaneously gloating and squirming, he wants the praise but doesn’t want to reveal his secrets. His description of the FDA as having strong consumer protection is outright wrong, the FDA cannot even be compared to similar European agencies. I also wonder why this all is necessary, he’s made hundreds of millions of $, why does he want more? I don’t buy that he is only being responsible and wants a set standard for consumer safety. We all know what you’re going, David. 2 Reply Michael C Michael C 1 day ago It's obvious Sinclair is not sincere. He is just out to maximize his pocket Reply 1 reply Pakistanicecream Pakistanicecream 1 day ago Good video. 1 Reply gabymalembe gabymalembe 5 hours ago I’m for NAD boosters, but not for trashing David Sinclair based on what we imagine he’s thinking. Reply The Pulse · 1 reply Αgapy Αgapy 1 day ago Looks like they got to him as well. 1 Reply A1b2 X2y1 A1b2 X2y1 1 day ago Use to respect sinclair, not anymore. I thought he had a wierd sinister look that I was willing to overlook, but now I know why 2 Reply 1 reply David Zip David Zip 1 day ago I think it seems weird because you do not understand what David Sinclair is saying. His company is undergoing clinical trials for a different type of NMN in crystalline form to be sold as a drug. That is why he is saying that he has never been involved with the marketing of NMN as a supplement, as your company donotage sells. While I think it is generally safe it is significant to note that Peter Attia now recommends that his patients do not take NMN. Previously, he had not recommended it because no study has ever shown that NMN increases longevity, but he didn’t discourage it them from taking it. NMN failed the ITP trial and other labs have also show no positive effect. He based his conclusion on the new study that shows that there is possible risk that it could increase the growth rate of certain types of existing cancers. That has by no means been demonstrated, but given even a slight risk and no proven benefit, he changed his recommendation. Reply Nonpareil storyteller Nonpareil storyteller 1 day ago Is this also about categorising ageing as an “illness” to be medicated? Reply b Vaccaro b Vaccaro 1 day ago (edited) Going to have to disagree with the majority of what's being said. My reasoning being is that David Sinclair has always been saying his goal for NMN is to be a fully regulated drug, preferably over the counter. So that means following the current laws on regulation, not sure why that would be surprising and also what would one expect him to say/do if that is what needs to be done. If the goal is to get the most people possible using it then that is simply not going to happen if it's only a supplement. The thing is the majority of the public and the Medical community will accept it's efficacy and thus use it if it's an over the counter drug and not simply a supplement. Maybe the majority of people's feelings about supplements will change in the future? I personally am the only one(aside from my wife), I know who takes NMN, my step Mom is interested in it but my Dad is disinterested and unconvinced of it's efficacy and my brother will try it but only if I send him some, LOL. People I know and met who are interested in longevity and overall health don't use and for the most part haven't even heard of it. Wether one agrees or not with the approach Sinclair is taking I do feel this has always been his position/intention and so at least for me this whole episode with the FDA was not surprising. 1 Reply linda r linda r 23 hours ago thank you! 1 Reply Mary Fuzzell Mary Fuzzell 3 hours ago Sinclair can't recover from his obvious greedy motives. There are many other researchers and scientist in the longevity space who are informative and worthy of our interest. Let's focus on them and be done with Sinclair who is best not given any more attention, Perfect payback for a greedy glory hound Reply Clay Wright Clay Wright 1 day ago This is not hard to understand. I recommend looking for more independent sources of research. There have been many brilliant, humanitarian physicians practicing orthomolecular medicine and studying NAD precursors for the last 70 years and their often overlooked papers and case reports are refreshingly free of corporate influences and financial motivations. 1 Reply Ken K Ken K 1 day ago Sounds like the good doctor, formerly known as Dr. S, has got some "splainin" to do 1 Reply TXVETJEB TXVETJEB 1 day ago Sinclair doesn't care about the broader human population. He cares about his money. He won't go without NMN, and neither will his father if it is banned. We will go without. It's clearMONEY drives his actions. Period. 8 Reply 7 replies Keith Robinson Keith Robinson 1 day ago He should go back on joe rogan and talk about this Reply Michelle Lyster Michelle Lyster 21 hours ago Your interpretation of "the safety of NMN" would be "the safety of the supply", my interpretation was David Sinclair was inferring to the safety of NMN. Mr. Sinclair was not clear with this statement and I think that was intentional. I think Mr. Sinclair took six weeks to write this statement so that he could say a whole lot of nothing without being caught in a big lie and still look like a good guy. I don't trust Mr. Sinclair and I no longer like him. You would be wise to be suspicious of Mr. Sinclair as well. If you think NMN being controlled by the FDA would be to our benefit, think again. It will be difficult to get a prescription and most people won't be able to afford it even without a prescription. Big pharma doesn't give their drugs away. Its all about greed. Its not just about the FDA, its about a big money grab for a miracle supplement. 1 Reply The Pulse · 1 reply Dimitri Villard Dimitri Villard 19 hours ago You’ve omitted the recent safety issue discovered by researchers at the University of Missouri, where cancer metastasizing to the brain was shown in animal models. Reply The Pulse · 1 reply StefanBe StefanBe 9 hours ago I am someone who takes nmn for health issues and I believe what is happening is very bad and we should take action and throw some hate in the direction of david sinclair. Reply sean J sean J 1 day ago Sinclair has shown is true colors......and my opinion of Sinclair has gone to zero...! 5 Reply TXVETJEB TXVETJEB 1 day ago His entire letter was an attempt at deflection. He lacks integrity, maybe not in his research, but clearly in other aspects of his life as evidenced by this letter. 6 Reply M. M. 1 day ago After Covid FDA is done, I'm not worried 5 Reply SuperiorMind SuperiorMind 1 day ago We're reacting to what we see or are meant to know(or think) directly. Humans are easy to anticipate like sheep running from a dog. What else do we know? Needless to say, there are other ppl with other interests involved with influencing this and many other changes coming - and not for our best interests. 1 Reply The Pulse · 1 reply Jarmo Syväri Jarmo Syväri 1 day ago 👌🙏 Reply Kenneth Marquis Kenneth Marquis 1 day ago Bottom line someone wants to make more money, drug companies or Sinclair Reply Dale Bullock Dale Bullock 1 day ago "David" may have a good PR rep... Reply cynthia price cynthia price 1 day ago I think u have been away from the states to long. The drug companies r powerful and will wield their power to do what makes them them rich. They could ruin anyone they wish. Wonder if David is under that pressure. Please carry on, appreciate ur content . 1 Reply The Pulse · 1 reply radientbeing radientbeing 3 hours ago Close to 84 and nmn user, and people comment that a am looking younger. Reply joe blow joe blow 8 hours ago Have you heard of ozone therapy? Reply Digital Buzz Digital Buzz 1 day ago I have been buying from Nutri Vita Shop. How do you verify fake from the real? Reply The Pulse · 1 reply Helen N Helen N 1 day ago Misleading means "thumb in the pie...." Reply linda r linda r 23 hours ago smoke screen, every one can see through Reply John Concannon John Concannon 1 day ago Vested interests. If people become healthy my taking supplements, then there is less profit for the pharmaceuticals. Follow the future cash flow. 2 Reply The Pulse · 1 reply BITCOIN TO $1,OOO,OOO,OOO,OOO,OOO BITCOIN TO $1,OOO,OOO,OOO,OOO,OOO 20 hours ago Crystalline NMN isn't anything new. Why is Sinclair acting like it's something new. 2 Reply David Zip David Zip 1 day ago Once again, Congress has already addressed the regulation of drugs and supplements. That is why the FDA exists. It doesn’t matter what the publicly accepted definition of a supplement is. All that matters is the language in the statute. You know, the law that Congress wrote. The reason he brings up NAC is because that is a similar case. The FDA could allow the continued sale of NMN. That is within their regulatory discretion. He would obviously want the readers of his statement to know this. It’s not that hard. One thing the FDA would never do would be to tip off someone how they are going to decide a regulatory matter. So my goodness, stop this ridiculous speculation. It’s a conspiracy. He’s been tipped off. He doesn’t use his full name when he signs a letter (no one does). On a positive note, if his form of NMN actually produces benefits towards longevity, then everyone will buy it. Because the existing NMN supplements have no proven benefit on longevity. Every study has shown that so far. But you would want to see a study performed by an independent third-party rather than his company. Reply M P M P 1 day ago At what cost to Sinclair's reputation? Instead of being feted as a distinguished researcher, he will be vilified as traitor, conman and opportunist. Pity. 4 Reply Bonnie Bonnie 17 hours ago I have lost much respect for Sinclair. Seems he has succumbed to greed. Those of us who take NMN know to research the companies that are reputable with 3rd party testing such as Donotage. I don't like it one bit. Reply Αgapy Αgapy 1 day ago Just don’t take any orthodox drugs. 2 Reply 1 reply Αgapy Αgapy 1 day ago Pharmsters overreach. 2 Reply Shelley Shelley 1 day ago This is so wrong 1 Reply Ben Ben 23 hours ago ohhh another David Sinclair video...for love of god leave him alone the guy want to make millions at any costs lol full stop! I just wish instead of selling his knowledge and research through powder/supplements which could harm or kill people " who knows right", he would just sell books or seminars and make money that way! Reply The Road To 120 The Road To 120 1 day ago No, you're wrong!!!! Anyone can be a co-founder and not be an owner or control a company. You are now accusing him of lying. I mentioned this before on this channel. Stop convicting people without proof!!!! Do you know anything about Business Law in the USA? So, just because he took six weeks to respond, this makes him guilty? Forget about the rest of the propaganda you're saying. You accused Sinclair of being an owner of that company, and YOU ARE ABSOLUTELY WRONG, AND YOU NEED TO ADMIT IT LIKE A MAN. You are now trying to justify your false accusation by redirecting attention to the rest of the letter, like that amateur wanna-be longevity expert, Dr. BRAT Stanfield. The bottom line is, did Sinclair lobby the FDA to ban NMN? The answer is a big NO. He is a freaking SCIENTIFIC ADVISOR of that company, not an owner, NOR IS HE ON ANY CONTROLLING BOARD. As such, he has no authority or legal standing to do any lobbying on behalf of that company. This here is a perfect example of the HERD PSYCHOLOGY!!!!! How in the world do you find someone guilty without proof? Your conjectures mean squat!!!!!! 3 His Wife's Breasts Got Firm Again The Pulse 12.7K subscribers Subscribe 164 Share 3,542 views Aug 15, 2022 #nmn #donotage #davidsinclair Pierre began taking NMN in December 2021. In this video he describes his physical changes and reactions of his family members. His wife was so impressed, she began taking NMN too and her results have been nothing short of shocking! This channel focuses on scientific advances spearheaded by Dr. David Sinclair at Harvard and others leading the world in anti-aging research. Subscribe and join me on this journey. Here are the links to DoNotAge where you can save on the supplements I'm taking. For DoNotAge use code "THEPULSE" to save 10% (can be used on multiple orders) (NMN powder) https://donotage.org/products/pure-nm... (NMN capsules) https://donotage.org/products/pure-nm... (Resveratrol powder) https://donotage.org/products/pure-re... (Resveratrol capsules) https://donotage.org/products/pure-re... (TMG) https://donotage.org/products/pure-tmg/ (CA-AKGK) https://donotage.org/products/calcium... (Sirt6 Activator) https://donotage.org/products/sirtuin... (Hyaluronic Acid) https://donotage.org/products/pure-hy... (Sulforaboost) https://donotage.org/products/sulfora... (Spermidine) https://donotage.org/products/spermid... (DoNotAge Subscription) http://www.donotage.org/subscribe/ This channel receives commissions for referrals to LetsGetChecked.com Use this customer link to save 25% https://trylgc.com/thepulse And enter code PULSE25 to save 25% of any of their test packages. Join this new Facebook Group where we can discuss all of this https://www.facebook.com/groups/57107... _______contents of video__________________ 00:00 - Intro 00:16 - Started With Healthier Diet 01:47 - Began Taking Supplements, Niacin, Resveratrol, Vitamins K2/D3 03:51 - Pierre Learned About NMN 06:11 - NMN Physical Results 08:05 - Living Healthy Is The Key 08:54 - Getting His Wife On NMN 11:10 - NMN Made His Wife's Brests Firm Again #nmn #davidsinclair #longevity #claudiaglows #podcast #health #lifespan #supplements #resveratrol #nad #lookyounger #donotage #antiaging #bradstanfield #letsgetchecked Subscribe button from here. https://www.vecteezy.com/video/807808... Disclaimer: The Content has been made available for informational and educational purposes only. The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. The creator hereby disclaims any and all liability to any party for any direct, indirect, implied, punitive, special, incidental or other consequential damages arising directly or indirectly from any use of the Content, which is provided as is, and without warranties. Chapters View all 56 Comments rongmaw lin Add a comment... bugsy1254 bugsy1254 4 months ago I've been taking NMN for a few months now. I'm 68, I've lifted weights for over 40 years so I suppose I'm stronger and fitter than most guys my age. I'd like to say something about the energy provided by supplementing NMN. It's not a buzzing go get em type of energy. It's more like I just don't tire out like I was doing before. It's like there is always enough energy to do what I want and even then there is more if I need it. I work full time and I do regular overtime and I still work out and have time with my grandchildren. I just don't get really exhausted like I used to. When I lift weights, I lift a few reps of 100 kg's and within a minute or so I'm ready to lift again. Previously, lifting 100 kg's would leave me fatigued for up to 5 minutes. NMN is improving my life in many subtle ways. 14 Reply The Pulse · 1 reply Chris Collingwood Chris Collingwood 4 months ago I’m 63 & my eyesight is almost back to how it was before it deteriorated when I was 50! I’ve been taking NAD+ boosters for just over seven years. Started with NR then switched to NMN about four years ago. 5 Reply 2 replies Alice J WHO? Alice J WHO? 4 months ago (edited) BTW, I've definitely noticed better heat tolerance. I assumed it was my ice-baths and perhaps the addition of Lugols Iodine, but the timing correlates more with the NMN, which I've been taking since January. Oh, and I've just remembered: (I'm a 56yr old cyclist) back in Feb and March I was feeling the cold nowhere near as much as usual on my bike, and the ice-baths and iodine didn't start until May and June respectively. Reply Matt Whitney Matt Whitney 4 months ago I’ve been on NMN, Resveratrol and TMG for 3 months now and I hadn’t really noticed too many physical changes. I had plenty of energy anyway and workout with kettlebells nearly everyday alongside a healthy diet and time restricted feeding. I consider this protocol a kind of insurance. However, the heat tolerance aspect is one metric that is demonstrating to me that NMN is having an effect. I can now sit in the steam room quite comfortably for the full 20 minutes duration, whereas previously I could only do about 12-15 mins max. 5 Reply Cindy Deas Cindy Deas 4 months ago I agree, the title of this video could have been worded a little differently. I do enjoy hearing people's good results from their individual protocols that include NMN and would love to hear from more woman. I turned 66 two weeks ago. I don't feel or act my age but, my mirror isn't necessarily cooperating with my anti-aging routine! 2 Reply Haitham Al-Hussaini Haitham Al-Hussaini 4 months ago I have been taking NMN for 3 months now with a dose of 1 g per day along with TMG resvertrol and D3 and so does my wife. for myself I have enjoyed a great improvement in different areas. just like everyone else my energy levels are much higher and my recovery time is much shorter but recently i experienced a great improvement in my acid reflux attacks which i used to suffer from while sleeping specially if I eat late and drink water late at night before sleeping. As for my wife he r thyroid symptoms improved tremondously after taking NMN 5 Reply Vee Vee 3 months ago (edited) Hi Marcel catching up on your videos. I Have experienced this, I'm on biodenical hormones ( 10 years, Im 60) and when they give me a little bit of estrogen With my testosterone my breasts have the same reaction. It's great! It also helps a lot with libido and with energy. But not the kind of energy I hope to one day get with the NMN.. I don't know if my heat and cold tolerance has improved.. Doubtful.. I live in a very temperate beach climate so I'm used to being comfortable lol.. I'm definitely looking forward to hopefully feeling like Pierre.. Reply Falcon77 Falcon77 4 months ago 2.5 years on NR and now 600mg NMN, nails skin and hair improvements in terms of evident outward changes, and I do feel more energetic and alert overall. Oh and my eyesight prescription improved which perplexed my optometrist Reply N Brown N Brown 4 months ago To me people taking NMN do NOT look any younger than they did before, and also do not LOOK like they have significantly slowed aging (although they like to tell you they look younger). But they DO clearly perform physically better - in endurance and recovery after sports. Just my personal impression. 4 Reply 1 reply jack mwa jack mwa 4 months ago No kidding.. I’m a female advocate and yes I have changed to better than my 30s. I’m almost 50yrs and planning 1st pregnancy due to nmn resveratrol efforts 10 The Pulse Reply The Pulse · 3 replies Terry Page Terry Page 4 months ago Interesting interview, I have noticed like you, that my tolerance of the current heatwave we have been experiencing in Europe, has been much better. Hopefully, my tolerance of the cold winter weather will be as good 🤔 4 Reply The Pulse · 2 replies Alice J WHO? Alice J WHO? 4 months ago Thanks, I found this so interesting, and Pierre and his wife look incredibly young, healthy and vibrant! Reply Barry Martin Barry Martin 4 months ago My upper body feels like & looks like I work out, it's great, I don't do any exercise at the moment. NMN 3 to 4 month. 👍 Reply Greg Johnson Greg Johnson 2 months ago Need a video on beneficial impact of Resveratrol, NMN and other supplements normally covered here on male libido. Reply Aftab Kahn Aftab Kahn 2 months ago What kind of AKG are you using You mentioned taking this supplement Kindly advise Reply Αgapy Αgapy 4 months ago I love the book by Dr William Davis and Perlmutter on the consumption of bread. Any bread or grains including rice, tapioca, and root vegetables. Reply H H H H 4 months ago Just replace bread with rye bread, keeps you full longer, has slower sugar release and it pretty decent on the healthy scale. 1 Reply The Pulse · 2 replies Ayo Ayo 4 months ago When you went to 2 grams of nmn what did you feel that made u decide to go back to 1.5 grams ? 2 Reply The Pulse · 1 reply Αgapy Αgapy 4 months ago Most people don’t just want to loose weight. They want to get healthy first. 1 Reply The Pulse · 2 replies Seekingthemiddle Way Seekingthemiddle Way 4 months ago Very interesting development for women. 2 Reply Connie Payne Connie Payne 4 months ago What made you feel like you were taking “too much” at 2 grams? Reply The Pulse · 1 reply Bernd Bernd 4 months ago Hi Marcel, please dont take this the wrong way ;) this is from the heart. But i always think, especially seeing how good you look now in the video with the blue shirt, if you would eat more and gain weight/muscles, shave the hair, get a short beard, (yes maybe contact lenses ;) ) and THEN do the picture compare from a few years ago.... do you even know? haha. you would look like a 33 year old. Reply The Pulse · 1 reply Tron Jockey Tron Jockey 4 months ago (edited) Sorry, I need to see some metrics on this with side by side photos 🙂 5 Reply The Pulse · 2 replies Steven Green Steven Green 4 months ago I thought he was 53 before he said 65. 1 Reply 1 reply Jim Bob Jim Bob 4 months ago Interesting 🧐 1 Reply Furious Doe Furious Doe 4 months ago Wonderstuff …. Will i get wings also ? 1 Reply The Pulse · 1 reply Kenneth Marquis Kenneth Marquis 4 months ago Narcel can you send me another discount cide fir Donotage thx Ken 1 Reply The Pulse · 1 reply James Robertson James Robertson 1 month ago Nonsense. Reply Angela BAIER Angela BAIER 4 months ago I am really sorry, I usually enjoy your content but as a female, I find the title of this video sexist and offensive. To this man - and apparently to you also - , the firmness of his wife's breasts seems to be the main benefit of her taking all these supplements. This may be elaborated on the video, I don't know. Am certainly not going to watch after this title. 1 Reply 2 replies BioHacked Lady BioHacked Lady 4 months ago Great video and awesome results. Let's collab. Reply Connie Payne Connie Payne 4 months ago What made you feel like you were taking “too much” at 2 grams? Reply The Pulse · 1 reply Bernd Bernd 4 months ago Hi Marcel, please dont take this the wrong way ;) this is from the heart. But i always think, especially seeing how good you look now in the video with the blue shirt, if you would eat more and gain weight/muscles, shave the hair, get a short beard, (yes maybe contact lenses ;) ) and THEN do the picture compare from a few years ago.... do you even know? haha. you would look like a 33 year old. Reply The Pulse · 1 reply Tron Jockey Tron Jockey 4 months ago (edited) Sorry, I need to see some metrics on this with side by side photos 🙂 5 Reply The Pulse · 2 replies Steven Green Steven Green 4 months ago I thought he was 53 before he said 65. 1 Reply 1 reply Jim Bob Jim Bob 4 months ago Interesting 🧐 1 Reply Furious Doe Furious Doe 4 months ago Wonderstuff …. Will i get wings also ? 1 Reply The Pulse · 1 reply Kenneth Marquis Kenneth Marquis 4 months ago Narcel can you send me another discount cide fir Donotage thx Ken 1 Reply The Pulse · 1 reply James Robertson James Robertson 1 month ago Nonsense. Reply Angela BAIER Angela BAIER 4 months ago I am really sorry, I usually enjoy your content but as a female, I find the title of this video sexist and offensive. To this man - and apparently to you also - , the firmness of his wife's breasts seems to be the main benefit of her taking all these supplements. This may be elaborated on the video, I don't know. Am certainly not going to watch after this title. 1 Reply 2 replies BioHacked Lady BioHacked Lady 4 months ago Great video and awesome results. Let's collab. Reply Turning 58 And Celebrating NMN The Pulse 12.7K subscribers Subscribe 281 Share 4,665 views Dec 14, 2022 #nmn #donotage #davidsinclair Celebrating my 58th birthday with this video talking about my NMN experiences and the many ways my life has changed since taking this amazing natural supplement. This channel focuses on scientific advances spearheaded by Dr. David Sinclair at Harvard and others leading the world in anti-aging research. Subscribe and join me on this journey. These are the holiday gift bundles I mentioned in the video https://donotage.org/products/kicksta... and https://donotage.org/products/kicksta... . (use code THEPULSE to save an additional 10%) Here are the links to DoNotAge where you can save on the supplements I'm taking. For DoNotAge use code "THEPULSE" to save 10% (can be used on multiple orders) (Fisetin) https://donotage.org/products/pure-fi... (NMN powder) https://donotage.org/products/pure-nm... (NMN capsules) https://donotage.org/products/pure-nm... (Resveratrol powder) https://donotage.org/products/pure-re... (Resveratrol capsules) https://donotage.org/products/pure-re... (TMG) https://donotage.org/products/pure-tmg/ (CA-AKGK) https://donotage.org/products/calcium... (Sirt6 Activator) https://donotage.org/products/sirtuin... (Hyaluronic Acid) https://donotage.org/products/pure-hy... (Sulforaboost) https://donotage.org/products/sulfora... (Spermidine) https://donotage.org/products/spermid... (DoNotAge Subscription) http://www.donotage.org/subscribe/ I recently worked out an agreement with a health levels home blood testing company and a 25% discount for my viewers. I receive commissions for referrals to LetsGetChecked.com Use this customer link https://trylgc.com/thepulse And enter code PULSE25 to save 25% of any of their test packages. This is my new Patreon page. I appreciate your support.https://www.patreon.com/marcelthepulse Join this new Facebook Group where we can discuss all of this https://www.facebook.com/groups/57107... _______contents of video__________________ 00:00 - Intro 00:26 - Key Supplements I Take 00:47 - Things That Have Changed Since Taking Supplements 02:52 - How I Continue To Feel Better Taking NMN 04:55 - How This Channel Surprisingly Began 05:30 - Beware Of Following "The Science" Too Closely 07:09 - Trust Your Body 08:25 - Addressing Conspiracy Comments 10:24 - Viewer Comment That Sums Up My Current State #nmn #davidsinclair #longevity #mitochondria #podcast #health #lifespan #supplements #resveratrol #nad #lookyounger #donotage #antiaging #reverseaging Disclaimer: The Content has been made available for informational and educational purposes only. The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. The creator hereby disclaims any and all liability to any party for any direct, indirect, implied, punitive, special, incidental or other consequential damages arising directly or indirectly from any use of the Content, which is provided as is, and without warranties. Chapters View all 142 Comments rongmaw lin Add a comment... The Pulse Pinned by The Pulse The Pulse 4 days ago I'm so grateful for all the birthday wishes. You guys are so amazing. Btw, I just got off the phone with a founder of a huge supplement company. I can only say, lots of optimism about the eventual NMN outcome and it should turn out ok for the supplement buying public. Will keep you all up to date on everything new I find out and share what I can. 21 Reply 5 replies Dawn Whitehead Dawn Whitehead 4 days ago Wishing you a wonderful birthday, Marcel! You have been and continue to be such an inspiration to so many of us out here in the world! Thank you for the time and energy you devote to the NMN education project. 🎉🥳🎈🥂🎂💝🎁 5 The Pulse Reply Gordon Smith Gordon Smith 4 days ago Alles Gute zum Geburtstag, Marcel. Thanks for the great advice and guidance on your progress. I’m a little ahead of you in years, but behind you in the NMN journey, so watching your videos and listening to your sound knowledge on the anti-aging has been very informative. We listeners are grateful to you for your wonderful videos, and please keep them coming! Have a great year ahead! 4 The Pulse Reply Michelle Gough Michelle Gough 4 days ago Wishing you a very Happy Birthday Marcel 🎂 🥳 you certainly don't look your age! Thank you so much for your channel you are an inspiration to all of us x 3 Reply ron russell ron russell 3 days ago Thanks Marcel, you are a great inspiration to us all and a blessing for sure! 2 The Pulse Reply P Jaworek P Jaworek 3 days ago Happy Birthday Marcel! I'm looking forward to my first birthday on NMN in January. What a wild ride since April. I didn't have many complaints before I started but I was always highly motivated by the possibility of an eternal'ish life or a healthy life in stasis. Frankly, it doesn't matter to me if I died suddenly; having that tangible substance(s) and subsequent lifestyle (leading to immortality) is what makes the whole thing so worth it and exciting in such a deep way. Reply michael canizaro michael canizaro 4 days ago Happy Birthday Marcel, I am glad to have found your tube channel. I recently switched to the Do Not Age supplements and have noticed a definite increase in my exercise regimen. Although I've just started taking NMM Resveritrol and TMG for a few months my weight loss and lifestyle journney has been going on for several years and I'm proud to say I'm down one hundred fifty seven pounds. I really appreciate what you're doing and you have inspired me to continue on this journey of eating real food, IF, exercise and taking the DO NOT AGE supplements that you recommend! . 2 Reply The Pulse · 1 reply Bill Kipper Bill Kipper 4 days ago (edited) Happy Birthday Marcel and congratulations! I have a couple of comments to make and a question. I'm coming up on four months of taking NMN and, like I said in the comments of the previous video, I've come to a point I feel much better overall and it's now just an every day thing. It's the new normal. However, a few days ago something happened. I wouldn't say I feel physically better, it just my attitude took a leap upward. Like everything is about 25% better. Things that annoyed the crap out of me six months ago were definitely less so after starting NMN but now, as of a few days ago, even more so. Maybe it's just a cyclical thing like circadian rhythms. I guess we'll see. As far as people our age all being on medications. I agree. I live in a major resort town and it seems like everyone is healthy and strong. A big health problem here is a sports related injury. If I go back home to Kansas City, everyone there is on meds and has some type of health problem or two and they look old. My personal opinion is that cities are toxic. The lifestyle plus all the pollution is killing people. Finally, a question. I'm researching supplements such as fisetin and quercetin, even though I already take both. Do I really need both? It seems that fisetin is more effective by far and taking quercetin as well is redundant. Any thoughts? Thanks and I hope you had an awesome birthday. 1 Reply The Pulse · 1 reply Om Villa Om Villa 3 days ago Happy birthday man!! I'm grateful for your posts! I started NMN and I was wondering what to expect. I also take other supplements you suggested. You are an inspiration. Go on and celebrate life like a 20 year old!! 😎👌🎂 Here feeling the same, so much younger, I used to do 20 to 40 sit ups, feeling old, yesterday I did 220!! And I was not (so) tired!! Your plan works!! I will keep following you!!😎👍 Reply Wendy Bruce Wendy Bruce 4 days ago Happy Birthday Marcel - Thank you for sharing your experiences with us. 2 Reply tyanite1 tyanite1 4 days ago Happy birthday, Marcel. Congrats on your progress. Your birthday gift for us is your encouraging update and story. Thank you. 2 The Pulse Reply Vince Vince 4 days ago Happy Birthday! I've been on NMN for about 5 weeks and feel younger & more positive already. Thanks! 3 Reply The Pulse · 1 reply Carrie Sumner Carrie Sumner 4 days ago Happy Birthday Marcel 🎂 you look great. I follow you by taking the same supplements and I feel great too. Thank you so very much. You are a star 🌟 4 Reply Tatiana Terekhova Tatiana Terekhova 4 days ago Happy birthday and many happy returns! Keep up a great work you are doing inspiring us to be healthy! 2 Reply Martin Von WunderGass Martin Von WunderGass 2 days ago Happy birthday mate! It was my bday a couple of weeks ago, and I'm a decade below you. I can see where you're coming from here, because for the past half dozen years i've dreaded my incoming bdays. I haven't even tried NMN yet, but I feel like your channel has inspired me most to give it a go, plus some of the other anti-aging supplements as well. 1 Reply The Pulse · 1 reply Mariam Watson Mariam Watson 4 days ago Happy Birthday Marcel. May you continue to be blessed into next year!!! NMN has also been life for me! 🌺🌺🌺🌺🌺🌺🌺 2 Reply C-Stance C-Stance C-Stance C-Stance 2 days ago Happy birthday! And thank you for the good work you do!! 1 Reply Susan Johnson Susan Johnson 4 days ago Happy Birthday, Marcel. Thankful to have found this channel and start my own journey back. 2 Reply Kevin Burris Kevin Burris 3 days ago Happy birthday! Congratulations on your amazing journey. I'm going to be 63 next month and my wife and I have been traveling along a similar path since July and we are not looking back. 1 The Pulse Reply The Pulse · 1 reply bernhardwalther bernhardwalther 4 days ago Happy Birthday! I wish you to keep the positive mind ! Life is definitively worth living :) 2 Reply katherine diane katherine diane 3 days ago Here’s to many many more happy birthdays!! 🥳 and many many more wonderfully informative and entertaining videos! Reply lidia chordas lidia chordas 3 days ago Happy Birthday to you Marcel! Sending you best wishes on this special day! 1 Reply Queenie Beats Queenie Beats 4 days ago Have a great day, Marcel. You are an inspiration. 2 The Pulse Reply Amanda Tännler Amanda Tännler 3 days ago Lieber Marcel Alles Gute zu deinem Geburtstag und ich wünsche dir viel Erfolg und Gesundheit mit NMN. Ich habe schon lange begonnen mit NMN, seit David sein erstes Buch geschrieben hat. Liebe Grüsse aus der Schweiz 1 The Pulse Reply The Pulse · 1 reply Kathryn Geen Kathryn Geen 3 days ago Happy Birthday! Thanks for your reasoned discussion of these supplements. 🎉 Reply MrBrianDuga MrBrianDuga 3 days ago Happy Birthday. Unfortunately I had to stop taking NMN because I started reacting to the TMG with sleep disturbance. It didn’t matter how early I took TMG either. I tried backfilling methylation a different way - with choline. But strangely choline supplements brought on depression. So I will sit on my one year supply of NMN until after my lyme treatment completes in 6 months. Then I will try again. Reply Victoria Santiago Victoria Santiago 4 days ago Happy Birthday!!! May you have many more 🎉🎉🎉 2 Reply brodheaded brodheaded 2 days ago Appreciate the tennis updates. My tennis status is equivalent to my life status in some ways. It's a great gauge for our overall wellness. Happy birthday 1 Reply DJ DJ 3 days ago Happy Birthday Marcel! Thank you for these videos. 1 Reply Candra D Candra D 4 days ago Happy birthday! You’re right,it does no good to worry. 2 Reply stephanie stephanie 3 days ago Happy Birthday! 💕 I’m trying to understand why people take NMN, which only doubles NAD+ blood levels, when NIACIN raises NAD+ by 8x. Even at a quarter the dose of the human studies, that’s still equivalent to NMN, yet a fraction of the cost. 1 Reply The Pulse · 1 reply Aaron Kitching Aaron Kitching 4 days ago Happy birthday. I always agree with everything you say. You speak very logically. 2 The Pulse Reply Brian Le Breton Brian Le Breton 4 days ago Happy birthday! Great channel. Thank you for sharing. 2 Reply LaiNY LaiNY 4 days ago Cheers to many more healthy years! 2 Reply Carrie Sumner Carrie Sumner 1 day ago Something I've noticed since taking NMN, Resveratrol and the other supplements is I don't feel the cold anywhere near as much as I used to. It's well below freezing in the UK this week, I'm petite and slightly built I usually really feel the cold, but now I notice tolerate it very well. Alongside better energy levels and sleep etc. Has anyone else noticed this? 1 Reply The Pulse · 3 replies thetackroomtx thetackroomtx 4 days ago Happy Birthday!! I was going to put a cake emoji but that's not really healthy 😂 You look Marvelous! 3 Reply The Pulse · 2 replies Brien Quirk Brien Quirk 1 day ago Marcel, a belated Happy Birthday and I want to thank you for your very helpful, informative videos! ! You look very good for 58, healthy and vibrant. I just have one concern, your voice sounds hoarse and strained, almost like there is a pro-inflammatory issue. I sometimes experience this too when I have taken too many supplements and I believe this has to do with the sheer amount of substances that the liver has to break down which can cause production of toxic intermediates that generate pro-inflammatory free radicals. The liver must use methyl donor groups to break down phenolic compounds such as flavonoids and I believe there is a limit to how many methyl groups are available. Even flavonoids such as quercetin and fisetin can be pro-oxidant and pro-inflammatory. at high enough dosages. I read a study that found quercetin has cytotoxic effects on mouse cells when it was much higher than the equivalent of an average person taking only 10 mg a day, that is quite a low dose! This study also found that the mice had a shorter life span with higher quercetin levels. I can't find that study now but if I locate it again I will send you the ref citation. I cycle some of these flavonoids and don't take them every day, though I do take resveratrol every day. Reply The Pulse · 1 reply M M 4 days ago Happy birthday, Marcel! From now on we may count the years backwards ;-) 3 Reply Wayil Zahid Wayil Zahid 3 days ago Happy Birthday... Thank you for your efforts/ channel.. It is informative 👍... 1 Reply gabymalembe gabymalembe 2 days ago I’ve been taking NR for 4 years and I feel good at 79, but like you I take a bunch of supplements, made dietary and exercise changes, so I haven’t the faintest idea which things are making a difference and which aren’t. How do you tell? 1 Reply The Pulse · 1 reply Kora Katar Kora Katar 4 days ago Wish you a very Happy Birthday! And many happy returns!! 2 Reply Mark Fitzgerald Ae86 Enthusiast Mark Fitzgerald Ae86 Enthusiast 4 days ago Happy birthday younger man. Have a lovely day 2 Reply Jason Hillis Jason Hillis 4 days ago 10 years older than me but you don’t look it! Happy Birthday! 1 The Pulse Reply gabymalembe gabymalembe 2 days ago Happy birthday! I think the upside of a drug company researching whether NMN can reverse Friedrich’s Ataxia and Alzheimers is that drug companies have the money to fund the research, and if it turns out to be convincing, many millions more people will be taking NMN and reversing these terrible diseases. Reply The Pulse · 3 replies michael michael 4 days ago Happy 58 years young! 🎉 2 Reply Manuel Rodriguez Manuel Rodriguez 4 days ago Felicidades que lo pases super bien 1 Reply M B M B 3 days ago Wow I tried it so many times but I never got anything from it…Happy Birthday!🎉 Reply toby0509 toby0509 4 days ago I am pleased people like yourself have seen benefits, unfortunately after taken basically the same stack for a similar amount of time, I have seen zero benefits. I am more exhausted than ever. So apparently it doesn't work for everyone. 1 Reply The Pulse · 4 replies Dawn Kesteloot Dawn Kesteloot 1 day ago What brand MNM do you use? I need this in my life too! Reply Joyce Sloan Joyce Sloan 4 days ago The 13th was my 72 birthday and thank god the NMN et al. If makes a HUGE difference. 3 Reply Jim Bob Jim Bob 4 days ago Can you expound on you NMN experience and how it relates to anxiety. I tend to be a somewhat anxious person and I would like to try NMN but I am concerned what effect it may have on anxiety. 1 Reply The Pulse · 3 replies Tom Wallace Tom Wallace 3 days ago Remind me how much NMN you are taking, and how much Resveratrol that is matched with? 1 Reply The Pulse · 2 replies Diana Mayfield Diana Mayfield 4 days ago Happy, happy & many, many more!!! 2 Reply Jamie Jamie 4 days ago I had a bad reaction from 500 mg of NMN in my yorgurt. I have a pre-existing seizure disorder , so maybe it triggered that. Got a painful headache and heat flashes on neck Reply The Pulse · 3 replies Daniel Edwards Daniel Edwards 4 days ago Happy Birthday my friend! 2 The Pulse Reply Toptastic Toptastic 1 day ago (edited) David Sinclair is a Guru in this industry and his work is amazing but, it looks like his recent involvement as an acting board member of the company, is driven purely by money. It doesn't feel like He is being completely open and honest about this, which is a shame and feels like a knife in the back to some of us! David Sinclair's MIB-626 version 2.0 of NMN won't be available to anyone for 2 to 3 years from now I think, eh? 1 Reply The Pulse · 1 reply House of Longevity House of Longevity 3 days ago Happy birthday!🥳 Reply holly troy holly troy 23 hours ago Happy Birthday, Marcel!! Reply Medical Panorama, Médico Medical Panorama, Médico 3 days ago Happy birthday Mr. before n after. 🎂 1 Reply The Pulse · 1 reply Kate M Kate M 4 days ago