Lifespan with Dr. David Sinclair

Welcome to Lifespan with Dr. David Sinclair 70,938 viewsDec 22, 2021 David Sinclair 209K subscribers Welcome to Lifespan with Dr. David Sinclair. Dr. David Sinclair is a professor of genetics and co-director of Harvard Medical School's Paul F. Glenn Center for Biology of Aging Research. Season 1 will be 8 episodes in total and will launch on Wednesday, January 5, 2022. New episodes will be released every Wednesday morning of both January and February 2022. This podcast can also be found on all podcast platforms, including Apple Podcasts and Spotify: https://lifespanpodcast.com/ My goal in creating this podcast is to discuss the science behind why we age and to share the newest research on what we can do to slow, stop and even reverse aging. In doing so, I hope to help explain the science in an easy-to-understand manner and I hope to help all our listeners in their journey to be healthier at any stage of life. Upcoming episodes will cover: why aging is a disease, the impact of dietary choices, fasting and exercise on aging, how various supplements and prescription drugs can protect against aging, why cosmetic aging occurs and how to combat it, the benefits and advancements of biotracking, and the future of age reversal. Please subscribe, share with friends, leave a comment or review, and most of all, thank you for coming with us on this journey into the mechanisms of aging and exploration of the tools for living longer, healthier lives! #Lifespan #DavidSinclair #Aging Please note that this podcast is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. 182 Comments rongmaw lin Add a comment... Medical Interventions (TRT, HGH, Stem Cells, etc.) For Longevity | Lifespan w Dr. David Sinclair #5 189,651 viewsFeb 2, 2022 6.5K DISLIKE SHARE DOWNLOAD THANKS CLIP SAVE David Sinclair 209K subscribers In this week’s episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante cover potential anti-aging interventions that are on the cutting edge. They share the latest research surrounding testosterone replacement therapy (TRT), human growth hormone (HGH), peptide supplementation, exosomes, stem cells, and cellular reprogramming. The idea of human rejuvenation and potential paths towards resetting the aging clock is also discussed. #DavidSinclair #Longevity #Lifespan Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Levels - https://levels.link/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Lifespan podcast website: https://www.lifespanpodcast.com Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsincla... Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclai... Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante Stay up to date with David's work to democratize biological age testing and insights: https://www.tallyhealth.com Timestamps: 00:00:00 Kicking Off Episode Five: Interventions on the Cutting Edge 00:02:39 Expressing Gratitude to the Sponsors 00:05:28 Testosterone Replacement Therapy 00:10:09 Human Growth Hormone 00:13:56 Peptide Supplementation and Regenerative Signaling 00:18:11 MOTS-c, Humanin, and Other Peptides 00:25:05 Exosome Therapy 00:31:56 A Primer on Stem Cells and Yamanaka Factors 00:37:59 Stem Cell Aging and Cord Blood Banking 00:41:42 The Therapeutic Potential of Stem Cells 00:43:37 Cellular Reprogramming 00:51:35 Resetting the Aging Clock 00:56:50 The Future Looks Bright 00:58:15 Next Week’s Episode: External Aging 00:58:36 Subscription and Support Options Links: Benefits and risks of testosterone treatment: https://bit.ly/35I3uTs Eunuchs are long-lived: https://bit.ly/3ukL1GU Longevity is enhanced in mice lacking growth hormone: https://go.nature.com/3AOTW4k MOTS-c and age-dependent physical decline in mice: https://go.nature.com/34aUgi6 Fatty liver disease, obesity, and an analog of MOTS-C: https://bit.ly/3Ho7GFE Humanin regulates lifespan and healthspan in mice: https://bit.ly/3Gy0lm1 Humanin ameliorates diabetes in mice: https://bit.ly/3ukiFw7 Mouse aging can be modulated via exosomes: https://go.nature.com/3oi0sM4 Exosomes and ulcer healing in older mice: https://bit.ly/3oEhPaf Generating induced pluripotent stem cells: https://bit.ly/3APMypv Vision loss after ocular injections: https://bit.ly/3L2yVIh Mesenchymal stem cells and human frailty: https://bit.ly/3s6kzxX Restoring vision loss in older mice: https://go.nature.com/335iysI Reversing epigenetic age in humans: https://bit.ly/342XXGJ Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. 507 Comments rongmaw lin Add a comment... daviessusan1000 daviessusan1000 6 months ago A discussion on menopause and HRT/TRT would be brilliant! 127 CYPRIAN KARIUKI CYPRIAN KARIUKI 6 months ago Am a young clinician in kenya.....this podcast always make me feel like am attending longevity lectures in campus. THANK YOU AND GOD BLESS YOU. 152 Larisa Inic Larisa Inic 6 months ago What about menopausal women and HRT? Would be interesting to hear about menopause and aging, maybe specific advice for pre and post menopausal women. 84 LittleOne3179 LittleOne3179 6 months ago (edited) I’m curious as to when inside tracker and your podcasts will include estrogen and other female hormones in their bio markers. I am 59 years old and a powerlifter, my inner age scored 9yrs younger than my biological age. My testosterone levels were even optimal, however the SHBG levels are an issue and I am sure not allowing me to optimize the testosterone I have. I sincerely hope more female hormones will be included someday? What can we do naturally to increase estrogen levels ? I’m currently investigating this and possibly HRT and would love your thoughts. Menopause isn’t healthy for any woman and affects aging. Thank you for all you do! 43 Samantha Samantha 6 months ago (edited) Looking forward to the entire episode that covers women's hormones (because we don't already live long enough?) Thank you! 45 Heather Schramm Heather Schramm 6 months ago Please address the hormones that are dominant in women also. Women have issues with dipping testosterone, but estrogen and progesterone also have a huge impact on women as we age. 10 Serge Lachapelle Serge Lachapelle 6 months ago (edited) I am following these podcasts with high interest... as I am 64 and on TRT, do intermittent fasting, weight train and take NMN and other supplements... (will be adding resveratrol). One issue that was not taken in consideration with regards to aging and testosterone is the fact that life is more than just time. How do you ballance adding life to your time vs adding time to your life. Quite frankly, TRT gave me my life back. My level of energy, motivation and general mood are way up with testosterone.... I would not live like I was before... The added estrogen that comes with TRT is actually cardio protective and has cured my joint pain... Maybe you should stay away of subjects you don't know well or you are biased against... Testosterone can actually be protective against prostate cancer and high levels of testosterone is actually being studies to treat certain forms of prostate cancer... I think your view is a little outdated... The biggest issue I have with all this longevity talk is the fact, it seems, that you have to choose between being vibrant, energetic but short lived or be starving, cold and low energy and live longer... Darn... Everything that makes me feel good seems bad (Mtor activation as I like my meat... testosterone as I enjoy being energetic and productive... ) ... Maybe I am looking for optimization and you are talking about absolute lifespan... Don't get me wrong, I love the podcast... great info to integrate into what I think will be a middle way for me... Cheers 8 19Jetta 19Jetta 6 months ago Thank you so much for being willing to talk about some of these therapies that are controversial. I really appreciate that you don't shy away from that. I support both you and Dr Huberman on Patreon and I regard it as an investment in my health. Thanks for all you do! 38 Alexander Toronto Alexander Toronto 6 months ago (edited) Again Dr. Sinclair, your colleague is asking Excellent and Thorough questions , that cover all points a viewer such as me was thinking about- such as the growth hormone discrepancy, among many other questions. Thanks to both of you for putting forth such interesting and fascinating information. 15 dulal rajbaruah dulal rajbaruah 6 months ago I am a G I surgeon but I take particular interest in chronic diseases and old age . It would be super interesting to see if we could really wipe out old age related chronic debilitating diseases in future. 42 Melinda Stefán Melinda Stefán 6 months ago I really like to listen to the lifespan podcast, but as a woman I feel women data are invisible in most of the researches. Could you please Dr Sinclair apporach some topics from the aspects of women? Especially when you talk about hormones like in this episode? It would be fab to hear about more similarities and differencies if there are any between a female or male body in terms of ageing! Thank you and congrats! And by the way, I’m Hungarian too as your grandma😊 15 Nick Nick 6 months ago All of this is fascinating to me as someone in my early 30s. I’m really hoping this keeps going in the right direction and quickly. 12 quater man quater man 5 months ago (edited) I would like to hear about the new studies on resveratrol that show it has no positive effect. And even takes away some of the positive effects of exercising. Could you discuss it in one of the future episodes? Would be great! 7 OttoT OttoT 6 months ago I had a low testosterones level but no libido problems' (thankfully) but I had hot flashes (I'm male) and osteoporosis due to it. There was no cause found. Due to injections and supplements it improved a bit but my risk of prostate cancer heightened. Then I started to do OMAD and now I don't need the injections anymore. My bones are becoming better and although just 0.1 under what is needed I have almost regular bones. Never thought that could happen. 14 sciencensorcery sciencensorcery 6 months ago As a child, I was growth hormone deficient and underwent GH therapy for most of my adolescence. Aside from catching up growth and development, people who are growth hormone deficient (whether as children or adults) take GH because being deficient puts us at higher risk for lots of major health issues and risk factors including visceral fat, high cholesterol, osteoporosis, cardiovascular issues, etc. So I was surprised to hear Dr. Sinclair say that populations with lower GH have fewer health problems. I'm also curious now: I understand his point about those who take GH recreationally or as a "body hack", but for those of us for whom it was/is medically necessary, what effect does the later-but-accelerated development have on us in terms of overall longevity? I was a late bloomer but developed pretty quickly when I did. I'm 40 now and am usually told I look much younger which seems like a good sign, but I'm wondering what effect the GH deficiency and treatment might have had on things. Has there even been any research on this? I feel like whenever GH is discussed even among scientists it's always in the context of recreational/elective use and it's hard to find information relevant to my situation. (I previously left this comment on your appearance on the Huberman Lab podcast but never got a response so I'm leaving it again here!) 32 Cheryl Simon Cheryl Simon 6 months ago Love it! Skin aging is what I've been waiting for!!! Can't wait to hear what you have to say on the next podcast🙌🙌🙌❤ 10 Billie Mann Billie Mann 6 months ago Man, Mathew is truly superb in slowing it down and also not loosing any threads. Thank you Sir! 3 magicfitzpatrick magicfitzpatrick 6 months ago I’m surprised you haven’t talked about one of the best things you can do for anti-aging. Donating blood should be on the top of your list. I would love to hear you talk about the benefits of donating blood. 5 Shel Chicago Shel Chicago 6 months ago David Sinclair just aged backward by a week while I aged forward waiting for another episode. 8 Hope Carlson Hope Carlson 6 months ago (edited) I'm loving this channel! It's my favorite kind of content to nerd out to.🤓 I've been binge watching, like Netflix. We humans and our genetic and cellular makeup are so incredibly fascinating. Thanks 🧬🧫👩‍🔬 7 Kurt Hoffmann Kurt Hoffmann 6 months ago (edited) What would happen if you cycled on and off trt and hgh so that you get the short term benefits, but then stopped those and go into a longevity mode where you do minimal mtor generation and lots of sleep etc..... so cycling between abundance memetics and adversity memetics... so you get gains during abundance mode and then maintenance mode during adversity mode, then cycle back into abundance mode and do it all over again. 7 Husaini Aliyu Husaini Aliyu 6 months ago At 75yrs I am. very keen on David Sinclairs achievement in longevity science.i take a lot of suppliment. 4 Liana - Holistic Intimacy Coach Liana - Holistic Intimacy Coach 6 months ago (edited) Okay, so episode 6 hopefully will be on hair (re)growth too. This is a big issue for me right now. Perhaps for many other women too. I will keep in mind about GHK Copper (I hope I spelled that right). It was mentioned halfway through this episode (and the warning about peptides and their negative side-effects). Thank you! 🙏 12 Orion Rodriguez Orion Rodriguez 5 months ago We're in a golden age of podcasts between this and Andrew Huberman podcast 2 tHE-ARTilect tHE-ARTilect 6 months ago Thank you for your time and content. As a blue collar know buddy, your work has kept me younger and fitter than I ever really expected possible. I've been following your work for years. So happy to have all this content in one place, cataloged, with such depth. ❤️ 🙏 truly grateful 4 Aldraz Aldraz 6 months ago (edited) This was a very interesting episode! I like this topic as it has not been repeated before in other interviews. I hope one day we can just take a pill that's gonna make us younger haha. 5 Be Strong and Love Yourself Be Strong and Love Yourself 6 months ago Another very interesting episode! I love this podcast! Can’t wait to know more about aging outside! ❤️❤️❤️ 2 Time Rider Time Rider 6 months ago Thank you for widening the boarder of understanding ageing 🙏 Thank you for your personality and work you put in yourself. Deepest respect🙏 2 Jawad Karim Jawad Karim 6 months ago Thanks unlimited.... awesome and greatest lecture ever in the whole world !... I am so lucky that I could watch your channel. thanks unlimited again 1 Ethan Cowart Ethan Cowart 6 months ago honestly feels good to be hearing someone like david say that peptides are promising and can be helpful if deployed properly and used properly. they have helped tremendously with a tbi that i got from a car accident. ive known this myself for a while but now it seems to be getting more known and looked at for the future. 1 Michael Tegler Michael Tegler 5 months ago David and team, Thank you for the continued commitment to optimizing life. A discussion on the Microbiome would be tremendous as I have struggled with GI issues (IBS-C) and believe I have been suffering with invasive candidiasis as I have recently taken fluconasole which provided relief not only in my stomach but also caused the pain and stiffness to go away from joints, back, shoulder, etc. I am 49 yrs old and have taken many antibiotics throughout my life predominantly for sinus related issues which may have caused this condition of excessive candidiasis in my body and am curious to know if there is a way to restore the microbiome and healthy bacteria to optimal levels without Fecal Matter Transplantation as this is not readily available in the US. I'd also be inclined to go away to a clinic of sorts for 30 days if you know of one that would provide the structure and support to restore the microbiome. Thanks again for all of your dedication and work! Aman Sharma Aman Sharma 6 months ago Great message at the end, thanks Matt and David for this episode 1 The Health Edge The Health Edge 5 months ago As the great 20th century philosopher Yogi Berra once said, "the future ain't what it used to be". This is a very exciting time in biomedical sciences. Would be very interested in your thoughts on the future of "quantum access" therapies that re-engineer the quantum morphogenetic fields that are the basis of our material blueprint. This, I believe is even more 'upstream" medicine. 1 ャン・ティオカ ャン・ティオカ 6 months ago The idea from the book that "aging is a disease and a treatable one" opened my eyes to the possibilities and I'm fascinated since. Rich Finaldi Rich Finaldi 6 months ago I was gonna take BPC-157 (Body protective compounds) for joint inflammation, I found out they are really act like a HGH effect with Angiogenesis , which literally creates new blood vessels that will heal organs , etc. etc. but the risk of cancer goes up , because cancers grow and get destroyed , but if we ever were to get cancer , added blood vessels could add to tumor growth as well as other diseases 3 Inazuma65 Inazuma65 3 months ago These podcasts are absolutely amazing and life changing! Thank you so much. ChessMasterNate ChessMasterNate 6 months ago Okay, I have watched all the videos thus far, but have heard almost nothing on the accumulation of intercellular junk, and just a bit about junk inside the cell, and what can be done about it. Because it looks to me like this is a major player in the current limits of human lifespan. There is more than one kind of heart disease, and the one killing the 100+ crowd is often Wild-type transthyretin amyloid (WTTA), where transthyretin amyloid builds up in the heart and some other tissues making the tissue stiff, and it becomes very tiring to even stand. 25% of men over 80 already show signs of this beginning. And this is just one of 25 or 30 proteins that can misfold and accumulate in the body. Then there is glucosepane. This Advanced Glycation End Product can't be removed by the kidneys, even if they are healthy, even if the other AGEs can be. This also builds up stiffening tissues and is implicated in a number of aging diseases. And what about lipofuscin? Maybe that will be covered when skin is the topic, but this crud is also in the brain, muscles, the heart and other internal organs. Then there are the studies about the intentional conjoined mice, where they saw the health of the older mouse improve, and the younger mouse go downhill. And after a series of studies they determined that it was chemicals in the blood of the older mouse that was the problem, and by plasmaphereses they could restore the older mice to health. That to me suggests that there are accumulations not just in tissue but in the blood. I don't know if healthy kidneys is the answer to that or if there are things the kidneys can't do anything about, like that glucosepane, which needs periodically removed. Then there is scar tissue. There are injuries within the body from infections and whatnot, and the body chooses speed over accuracy during repair, but if you live long enough, these sloppy repairs will also accumulate. We also accumulate infections that the body can't ever completely eliminate. Older people have much more of these than younger people. Things like toxoplasmoses, and cytomegalovirus. Ultimately, I don't think these things are benign. It is likely they wear down defenses, or promote diseases we haven't yet tracked down to them. I sure would like this accumulation topic discussed. 4 Diane and George Explore Diane and George Explore 5 months ago Dr. Sinclair, we are SO grateful for the work you are doing and sharing! Would you consider discussing how far off we are from being able to grow heart valves using a person's own stem cells? My husband was born with a bicuspid valve (and so was his father). He will eventually need a valve replacement, but because his immune system is so strong, we are concerned that his body will reject a mechanical or animal valve (as his father did). Can you refer us to someone who is doing work in this field? Natalya Marcus Natalya Marcus 6 months ago Thank you so much for your webcasts! Do I not need to take collages supplements since I take NMN, Reservatrol, vitamin D3 withK2, and metformin (about to start)? Theoretically, if my body thinks its "younger", it would produce collagen in abundance? 1 igalbog igalbog 6 months ago As always, interesting to watch and learn about the cutting edge in anti-ageing. Thanks David and Matthew! Dr. Sinclair is looking younger than usual lately - any recent changes in the protocol? 5 Ainsley Ameerali Ainsley Ameerali 6 months ago Love this !!! Thank you dr David!!! You rock !!! 2 David Sinclair Robert Mariano Robert Mariano 6 months ago This podcast on anti-aging along with the research on CRSPR and gene editing/disrupting really is amazing. The only thing better than this would be a way to transplant consciousness into an already younger version of oneself. I watch this on YouTube then I listen to it again on the podcast El Ensayista El Ensayista 6 months ago Fascinating idea that of HGH + diabetic drugs to reverse aging + improve physical performance. One thing I noticed for facial aging is if you want to reduce wrinkles or dark circles you need not be losing fat at the same time, or preferably even increase calories. Why? Its seems that whatever topical therapy you apply can dry your skin if you dont have fat to sustain it. I even use honey+curcumin+green tea, which isnt supposed to dry, and it still dries if I dont take care for it. Btw if it dries then your face looks more aged not less, thats why its an important issue and challenging the idea that we always need to decrease sugar to look younger. 1 Victoria E Victoria E 6 months ago Hello Dr. Sinclair, thank you for your program this week. I have a question of you have time to respond. You mention fasting to stress the body as a anti-aging treatment. Does that extend to ingesting or rather not ingesting liquids? Is dehydration not the same kind of stressor? Thank you for your response. Joey Funk Joey Funk 6 months ago Can’t tell you how many people I’ve recommended the book Lifespan too it was great. Very excited to see how well we can Amplify these Sirtuin genes 1 Ccowdog1 Ccowdog1 6 months ago You both are lovely! Lol 😆 thank you for telling us what doctors don't- please do one on menopause! 5 Larry Shepperson Larry Shepperson 6 months ago ive been a fan for a long time and this is the best one two punch in longevity.Thanks a million keep up the great work Sirt1 Sirt1 6 months ago I started really praticing and supplementing for anti-age due to hair loss. Do you know what could really help with help regrowth and regeneration? 3 andrew walker andrew walker 6 months ago The HGH discussion skipped over the TRIM and TRIMX trials done by Greg Fahy, and showing age reversal with epigenetic clocks. Shame - I really wanted to hear Davids view on that work 3 Erica Erica 6 months ago Thank you Dr David Sinclair! Athletic Green is just delivered to my house now. Appreciate your videos it’s so helpful. Thank you! You look great in that blue sweater.❤️ 2 Sonny Matthews Sonny Matthews 6 months ago I would like to know David's testosterone levels, and what range would be considered optimal? At what point should you supplement? 2 Nico McLane Nico McLane 6 months ago My main takeaway today --> A real and sustainable solution to survive the zombie apocalypse - "brains to go" ... I love this PODCAST! Makes me feel smart. Haha 1 STEFAN Daniel STEFAN Daniel 6 months ago I love you David, i can‘t wait to put my hands on your book ( Lifespan) i already apply most of your advices, but i take it slowly, currently eating 2 meals a day instead 3… 7 Joanne Tran Joanne Tran 6 months ago Thank you for this episode , I can’t wait for next weeks! Can you please also cover the effects of BOTOX to the skin for long term use (I’m yet to use as I’m afraid of the long term effects!) 6 mirusvet mirusvet 6 months ago Thank you very much! Looking forward to the next episode! 2 David Sinclair Little Queen Little Queen 6 months ago The FDA just doesn’t want us to take our health into our own hands. Period. 8 That Chess Guy That Chess Guy 6 months ago Thanks for making this video series! 2 David Sinclair Ligia Sommers Ligia Sommers 6 months ago Best podcast !!! And I study a lot ! Helpful and hopeful.⭐️⭐️⭐️⭐️⭐️🙏🏻❤️‍🩹✨🌹 angeline sarol angeline sarol 6 months ago love your pod cast Im 56 and look and feel 36 Topics you cover so fascinating and your partner covers every detailed information Huang Wee Huang Wee 6 months ago This is very insightful and straightforward. Thanks to both the speakers 1 Chrystabell Music Chrystabell Music 6 months ago David's smile at 42:23 after Matthew's statement is one of great satisfaction! love it Kunal Singh Rathore Kunal Singh Rathore 6 months ago Just finished listening to the entire episode on Spotify & Damn it started a war of neurones in my brain. Sure now I don’t need any pre-workout boost. Thank you once again for everything that you are putting out for all of us to be better. Can’t wait for the next episode.. Excited🤪 6 Daron LeBlanc Daron LeBlanc 1 month ago Great discussion!!! Been a fan since your Rogan interview. Ready your Lifespan book 3 times, Can't get enough of Mr. DS Armie Flores Armie Flores 6 months ago So thankful for great information and very interesting podcast Lori Smith Lori Smith 5 months ago Most definitely! I have found that in my city (Pittsburgh, PA), which is primarily a traditional medicine community, the majority of physicians are very hesitant to prescribe HRT and claim beyond a certain age, your risk to develop cancer is very high. I know this isn’t supported by current research. Also, there are few functional medicine practitioners who also have MDs - a background I am seeking so I can receive advisement from both perspectives. My DO wouldn’t even consider prescribing bio identical HRT and told me I should find a gynecologist who would. Even these practitioners are very hesitant and keep referring to older research in their explanations. This is SO very frustrating, and leaves many women struggling to find care that could prevent many downstream problems. Martin Martin 6 months ago (edited) ❓In a previous episode, David mentioned that too much iron is bad. But how much iron is too much? What is the maximum level for Hemoglobin [g/dl] and Ferritin [ng/ml]? Which values are optimal (for an adult)? 3 Cheryl R Leigh Cheryl R Leigh 6 months ago More than anything else I am interested in how to enhance and sustain mental and intellectual acuity. 1 Min Min Min Min 6 months ago Every Wednesday now is like xmass morning! Running to check what gifts I got!!! Amazing! 6 Stephie Getsit Stephie Getsit 5 months ago I am loving this series. Currently I am on my second regimen of Fiesitn (hit and run method) I know ysaid it's still experimental however I have been scathing of Damage and repairing for agent orange poisoning for decades. Doing rather well at it. So I have some savy and knowledge. About what I am doing. Deb J Deb J 6 months ago I can't believe you completely left out HRT and menopause. 13 Egg Mendy Egg Mendy 6 months ago Wonderful, wonderful episode, as always. So informative and well-presented! Thank you for doing these. Adrian Hoyle Adrian Hoyle 2 months ago I wish I had seen this podcast earlier, I had been using peptides to deal with an injury that got worse and to boot, I now have arthritis in my hip and big toe. Rebecca Jackson Rebecca Jackson 6 months ago I would LOVE to hear if they have done any kind of research on humans + ageing re some of the more advanced meditation techniques that can be practiced. I’ve personally had some very interesting experiences where energy has surged through me feeling as though it penetrates all my cells to the point of euphoria. It’s very powerful and I can achieve this daily by doing my practice. Along with living in a state of peaceful loving kindness and open hearted ness which physically feels very good moment to moment I can only imagine this must have a positive impact on ageing? Maybe not. I’m sure there’s some studies currently focusing on this however I can imagine it’s harder to measure as it can’t be done on mice. Or maybe it can be?.. ChessMasterNate ChessMasterNate 6 months ago It would be great if the eye treatment could be tried on the cochlea of the ear to stop ear ringing. I blew out an ear in Jr. High, and it has rung ever since. And it has gotten worse. I suppose it is harder to ask a mouse if it has ringing in its ears. I suppose you could wipe out all the little hairs and see if you can grow them back. And check various frequencies. Alistair Hughes Alistair Hughes 6 months ago Can you talk about hair? Male pattern balding and grey hair? And also talk about Finasteride use and its long term effects. 4 stock study stock study 6 months ago Hi David, I studied your book and have been using NMN, etc since Feb 2021. My stem cells have been banked and I have 1.4Billons of my cells IV'ed and IN'ed in my body since 2020. Mysteroo Mysteroo 5 months ago Frustrating that I can't take metformin without a prescription. Would love to try this out Lala Lala 5 months ago Wow I was wondering if they offered a discount. 25 % is great. I'm just about to get back on Resv, Berberine and NMN. I've been using senolytics sparodically, and during pre and post vaccine. After a year off, feeling like crap tbh 😆, so thanks for making feel human and hearing you did the same at some point. I do remember how fabulous I felt a year ago. This time I want to do full bloods, and track properly not just anecdotally. Thank you 😊 ✌️❤️🇭🇲 Explorers of the World Explorers of the World 5 months ago thank you for very valuable and useful knowledge, I would be interested in the topic of fertility in women, how to care for it and whether it can be kept Lurksin1 Lurksin1 6 months ago Love this area of research. How do you feel about Wim Hof breathing techniques and the research on improving mitochondrial function as well as meditation, hormesis in general for lifespan Brandon Brandon 3 months ago I’d love to hear any progress on restoring dental health and whether or not teeth could be regrown. 1 Rosie K Rosie K 6 months ago First time I’m seeing he looks healthy and skin is glowing only little inflammation on left shoulder and little on left side and front of the elbow. well done I can respect you now. If you’re advocating for your job or what you believe in show the evidence in your body. Patrick Day Patrick Day 5 days ago It's nice listening to people that really know their stuff. It's been about five years since last diving into peptides. I've even talked with a biologist on a dating profile about how incredible peptides could be for so many health issues she criticized me said I didn't know what I was talking about. Lol I've taken a few. I hope the fda seeks advice from people like David Sinclair before blanket banning substances. Sharon Sullivan Sharon Sullivan 5 months ago Rheumatoid arthritis, and sexual performance as we age. Thank you. Podcast very intriguing. Keep it coming. Have fun in Utah! Ciarog Ciarog 6 months ago (edited) Are you referring to peptides that were made in Russia and now available here? These are said to heal the heart,liver, brain and other organs. What do you think? They are said to extend lifespan by 30%, but I think that means expected lifespan of an already ill person. They are made from animals or synthesized. 1 Brian Starr Brian Starr 6 months ago (edited) Good morning, Matt. You have a John Heilemann-esque vibe. Take it as a compliment. I think you do a great job of co-hosting, asking enlightening questions and keeping the conversation flowing. David is pretty good, too. Signed, Matt's mom 1 C M C M 6 months ago I’m so excited for the weekly releases, I don’t put that kind of value into any other channel 4 Des Nicolaou Des Nicolaou 5 months ago I am a peri-menopausal 51 year old woman. I would appreciate it if Dr Sinclair could talk abt the menopause & how we can help ourselves maintain good health. I am getting conflicting advice abt taking HRT & I am unsure abt what I should do/take. gruuvmunky gruuvmunky 6 months ago Question- what specifically counts as 'fasting' time with regards to the health benefits IE-Autophagy? If you eat once a day at dinner time. That food is digested for quite awhile. If it's still in your digestive system in the morning & affecting your blood levels...then when does the actual fasting time start? Thanks for any info!!!! Love this channel 5 Patrick Day Patrick Day 5 days ago Yamanaka factors have come so far way faster than I expected when I was first reading his research I thought it was going to be 10 or twenty years to make any real progress because of cancer. Eddy Mac Eddy Mac 4 months ago I love David. I listened to most of the podcasts he was on. Did anyone notice that hes more on the be cautious side of testosterone and GH compared to some of the other podcasts he was on? If this was my first time listening to him, I would second guess taking test and GH. Its odd that he kind of switched his stance on it, or maybe I just misunderstood him. When he was on Ed Myletts 1st podcast it sounded like he was all for it. Steve NJ Steve NJ 6 months ago I can't even explain my gratitude for having the Most modern science, cutting edge know-how and knowledge and the ABILITY to be shared to the mass populace without being chewed and misinterpret by for-profit news. This IS the greatest #realized #purpose of the #internet itself to #spread #knowledge! Thank you and my sincere gratuity #DavidSinclair 1 Dahs K Dahs K 6 months ago So excited to listen to this one. Thx Dr. Sinclair Barbarellee Barbarellee 6 months ago Maybe any interest in discussion on microchimeric fetal-derived placental cells rejuvenation and effects of parity on longevity? Awesome work! :) Iron Maiden Fitness Iron Maiden Fitness 3 months ago I would love to hear more about whether GLP-1 is similar to metformin or a good idea to increase health span wigglywrigglydoo wigglywrigglydoo 5 months ago What roles do our vagus nerves play on immune system, digestion, nervous systems etc? Especially when the vagus nerve (which cannot regenerate) is compromised by accidents or impinged through the now common, C spine curvature loss? Is it worth integrating cervical spine ligament regeneration into the science of aging healthily? Articulate99 Articulate99 2 months ago Always informative, thank you. Daniel Train Daniel Train 6 months ago (edited) I would like to learn more about how the Yamanaka factors work, their relationships with sirtuins and how they are used in regressing adult cells into stem cells. Julie Sønder Julie Sønder 5 months ago Hi David What an Interesting podcast. I have followed your Work for at long time. I would Love to hear more about how Women can apply these strategies. I’m a female Who is In the reproductive age and would like to start a Family soon. But many of the recommendations that you mention is proably not suitable for pregnancy? or can it be combined. I’m refiring to the supplements you mentions and the fasting. Lümmelmann Lümmelmann 5 months ago I must admit, our good friend (and my personal idol) Dr. Huberman does look significantly older (but also more "androgenic"), since he started his "TRT" (I think he startet about January 2021)... SyrupGoblin SyrupGoblin 6 months ago How long are we thinking until going in for a stem cell treatment is affordable for almost everyone? Cynthia Rucker Cynthia Rucker 6 months ago Amazing and wonderful. Thank you!! 1 David Sinclair Raluca Simple Living Raluca Simple Living 6 months ago Love this podcast, also bought your book, i'm enjoying it very much 1 David Sinclair Ondrej Unspecified Ondrej Unspecified 6 months ago Serious question: Has anyone studied or even considered mTOR activation cycling? What I mean by that is high mTOR activation for couple days and then low activation. The reason to do this would be to build muscle for several days, then rest and clean up the body. From everything I know about mTOR and autophagy (very limited knowledge), it seems to me it's not necessary to have mTOR downregulated and autophagy activated constantly. What I'm trying to test is if there's upper limit of autophagy activation or some point where longer autophagy activation has diminishing returns. The other limiting factor is how long it takes for autophagy to activate (2-4 days?) The main variable is length of each cycle, it could be days, weeks or maybe even longer. I know about intermittent fasting, which is great, but it seems to me that autophagy activation requires longer mTOR downregulation. eg. I cannot eat large steak every evening and expect it to work. There's also a reason why Dr. Sinclair stays on low meat diet over longer periods of time. Why even think about this? Building muscle has a lot of other health benefits, especially in elderly people. Dr. David Sinclair, could you please elaborate a bit on this topic? Thank you! 1 DrPubz DrPubz 5 months ago I have been following Dr. Sinclair since I was 25. I am 22 now. 2 Louise Corrans Louise Corrans 6 months ago I guess a valid question to ask is: how much is longevity worth it if we feel miserable? What I am getting at is that the adversity memetics are generally not fun, don't make us feel too great in the moment (fasting, hot and cold extreme etc) and yet "abundance hormones" like TRT and HGH seem to make people feel so healthy. Would we rather live a bit shorter and feel amazing? Or have longer, more miserable times? Also, as doc hinted, restoring levels to healthy baseline doesn't seem to be problematic? Giselle Baham Giselle Baham 5 months ago Can you tell me about Proline, Lysine and Choline? I was told these were key amino acids to take if you’re wanting to generate collagen in your body. Maribel urquieta Maribel urquieta 6 months ago Podrías poner en Español ,por favor 🙏🏻 me gustaria😔que puedas hacerlo en español 1 nothinghere ligma nothinghere ligma 6 months ago I want a crossover between Dr. David Sinclair and Dr. Steven Greer Samot-sari ni Okee Samot-sari ni Okee 6 months ago I will be turning 74 on March, a Filipino and has been taking NMN for 3 years now plus several supplements. How can I send you my story. I believe I could be a good example (anecdotal) being on the 4th quarter. 1 Daily Bible Verses Daily Bible Verses 3 months ago I wish you could speak about other supplements that promote growth hormone like arginine,ornithine, niacin, choline, tryptophan, melatonin, etc. Andy Atmosphere Andy Atmosphere 6 months ago David is probably one of the best in his field. BUT you can tell he’s not a fan of HGH or increasing testosterone for the purposes of muscle gain. He don’t like to workout, he’s not a fan of body builders… even though there’s NO scientific evidence that HGH (in the long term) IN HUMANS causes long term health problems. The Stream of Life The Stream of Life 4 months ago I have been on hormone replacement therapy for decades. I'm 80 now and do not look my age. Most think I look about 60. Hormone replacement therapy has been my life saver .... Bluecloud909 Bluecloud909 5 months ago Hey Dr Sinclair, could you please invite Dr Thierry Hertoghe on your podcast to talk about hormones and longevity? Thanks Lee Ferguson Lee Ferguson 1 month ago I am still confused by the fact that David says he drinks athletic greens every morning but also states that he fasts every day? Can anyone clarify? Great podcast by the way 👌🏻 Ali Ghadban Ali Ghadban 6 months ago (edited) I have a question regarding fasting. Does fasting like 16 hours a day enhance your metabolism, testosterone and GH levels? Do we lose muscle mass while fasting for this peroid of time? Dominique Zivkovich-Brady Dominique Zivkovich-Brady 6 months ago Please note that Levels is currently available in some American states only. I’m in New Zealand & desperately want it! 😂 Maximiliano Perata Maximiliano Perata 6 months ago LOVE YOUR PODCAST... Peter Peter 6 months ago @52 min on thymus regeneration: See research of Janet Lor which showed that older (65 to 80) who cycled alot over many years preserved their thymus output of T cells and had immune function of people decades younger. It's also known from other research that exercise increases NAD+ and modulates other metabolic factors towards younger states. Ermete Trismegiusto Ermete Trismegiusto 6 months ago If we don't reset our "EGO", extending our life will only do worse damage than we have done so far, believe me .... 1 Bojan Lukovic Bojan Lukovic 6 months ago I would like to ask about supplementing with Pterostilbene. Dr. Sinclair hasn't mentioned it, but he mentioned Resveratrol, Quercetin and Fisetin. Pterostilbene is, I think, in the same group. What is his opinion about it? 1 joão Cor7eZ joão Cor7eZ 6 months ago agree on everything, on the exogenous stuff,( TRT's and steroids, the HGH etc) but is clear that he believes that even endogenous test levels are bad for longevity ( he never speaks on resistance training, rarely eats meat, he saying the eunuchs live longer completely anecdotally with no scientific base whatsoever etc) and I believe he is super wrong on this , and will regret it in the future, when he becomes a super frail 75 year old. rachel newport rachel newport 6 months ago Its funny... I see this video is up, and I know immediately what my husband is doing. Its like magic! 1 Steve Gerrior Steve Gerrior 1 month ago Willing to share any ideas on how to decrease the deleterious effects of T supplementation for those of us who clinically need it due to a disease process? cas alderliesten cas alderliesten 6 months ago Is there maybe something you can tell us about how drugs like Methylphenidate (ritalin) might effect longevity? frontrowtennis frontrowtennis 5 months ago Are there any supplements that can help with Osteoarthritis in the knee due to multiple meniscus surgeries and a lifetime of sports? Thank you! GoTo Mars GoTo Mars 6 months ago Very very exciting times. 3 months for every 1 year lived right now…the near future is amazing. PaNen HOKGI PaNen HOKGI 4 months ago THOUSANDS of THANKS So Much for Dr DAVID SINCLAIR + Mr MATT LaPLANTE * for your Unlimited + Immense + Continuous contributions to Humanity Prosperity. Those Valuable TIMESTAMPs are extremely useful. Haliotro Haliotro 2 months ago Mmmm love medical advice from non-medically and even non-biologically trained guests Joey Firestone Joey Firestone 5 months ago What’s your thoughts on umbilical-cord derived multipotent mesenchymal stem cells (MSC's)? Tự Học IELTS Đi Tự Học IELTS Đi 6 months ago It's interesting to think that one day we might look as young as our children. 1 The Stream of Life The Stream of Life 4 months ago I'm drinking athletic greens for 3 months. Great product José Augusto dos Santos Silva José Augusto dos Santos Silva 6 months ago there is any correlation between tattoos and risk for your health in long term? I'll be glad to get an answer! thanks Joey Funk Joey Funk 6 months ago TRT leads to muscle growth and typically more food intake to support growth which is the opposite of caloric restriction 1 Vibha Spalding Vibha Spalding 6 months ago This is interesting podcast but the peptides and hgh, trt they talk about is virtually not avaulable in UK. Sone of them still in research and state not for individuals but sold for research. All very expensive. 1 Victor Koehne Ramalho Victor Koehne Ramalho 6 months ago Studies show that fasting for 24, 48, 72h can spike growth hormone up to 3 times; I wonder if this effect can compensate for the age reducing autophagy effects... And in the end we get 0 reversed years chris lapiana chris lapiana 6 months ago Would you please read someone's DNA and Blood work from inside tracker? It would be fascinating seeing how you think / providing insight. I would offer up mine 1 Vivian Castro Vivian Castro 4 months ago May I suggest you change the title so you put the number of the episode so that we don’t have to open more to figure out which episode it is? Thank you! Loving it! Jose Ernesto Bello Ravelo Jose Ernesto Bello Ravelo 6 months ago Thanks you guys! Blessings. Jawad Karim Jawad Karim 6 months ago Greatest Scientist ever in the whole world *** . IvanAndreevich IvanAndreevich 6 months ago Fastest longevity channel to 100K. Congrats! 1 Chris Hogan Chris Hogan 5 months ago I wonder if you could induce pluropotence in cells with just the mRNA of the Yamanaka factors without getting some of the deleterious effects. Lora Solomon Lora Solomon 6 months ago Great video info, love your channel...! David Needham David Needham 6 months ago David I’m taking a supplement that claims to be pure NAD. Is that even possible and if so is it worth it? I’ve been combing your videos and I’m wondering if I’ve been had. You take the precursor obviously for a good reason. disease /health /diets disease /health /diets 6 months ago Thanks! dr David for amazing apisodes. Luke Kennedy Luke Kennedy 5 months ago Dave, as a fellow Australian I'm not alone when I ask how we can use inside tracker from Australia without using an American address? Matthew Harries Matthew Harries 6 months ago Damn I was hoping he was going to say the use of TRT and HGH was a good thing for aging Athena Adventures Athena Adventures 6 months ago 34:06 don’t get on Dr. Sinclair’s bad side 1 Angel Dahnke Angel Dahnke 3 months ago Brilliant. As always! Judy Fasola Judy Fasola 6 months ago Dr....😊 forgot to mention... I have Mild aortic regurgitation valve and colesteral a little high... good cholesterol is good not on statins... very active 72 year young lady ...hip osteoarthritis but hasn't slowed me down keep active ... I'm on your protacal ...is this ok for me to do ... Thanks sooo much ❤️❤️❤️ Aurora Maria Lopez Reggiori Aurora Maria Lopez Reggiori 4 months ago (edited) What is the name of the company/ which is the company for exosome diagnosis that you were mentioning?thank you so much 🙏 great podcast CJ CJ 5 months ago I banked my child’s cord blood almost 12 years ago. So many told me that I shouldn’t but it’s an insurance policy as far as I’m concerned. My doula told me that she didn’t recommend it as it probably won’t help. I told her I hope my house doesn’t burn down, but I still have fire insurance just in case. 😜 Dian Ginsberg Dian Ginsberg 6 months ago Yes. That is why testosterone pellets hurt women!! Appropriate well monitored menopause bio identical hormone replacement is the key. Mikhail Tronik Mikhail Tronik 6 months ago Holy shit man, you guys are Gods. Reversing aging in dead man's brain cells, sounds exciting! 1 LaDonna Bella Villalobos LaDonna Bella Villalobos 3 weeks ago You are probably gonna laugh at me when I tell you this but after that virus and being in the hospital three months in the ICU they started giving me insulin shots in my stomach oh that was horrible I don’t know why they were doing that I think they was using me as a human guinea pig anyway I did make it through it and gained 200 pounds so I left there with two of me I am 510 but I don’t need to weigh over 300 pounds it only took me six months to get it under control, I guess I can give my opinion here OK in the morning and boiled water I put lemon cinnamon stick basically that’s about it and something else happened did you know that there are only green and brown eyes I’ve had green eyes since I’ve gotten older but I found out that I had a lot of toxins so the lemon water clean my liver so well because the hospital also gave me a fatty liver that the lemon water cleaned your liver I mean you could try to research it and I’m just giving what I did OK not a scientist not a doctor nothing like that I do a lot of research had a health food store that’s it that I grew up in a family with a grandma that made us take certain things to keep us healthy and we never got any whatever them shots are against diseases because my uncle is a chiropractor so I knew they were bad way back then thing I remember the most about what he said was the mercury Kontan I think yeah I’m just going by memory I’m 68 1/2 and that’s when I was growing up, I hope they don’t get upset with me saying things like this on here but I love to help people get healthy they prescribe me the type two diabetes Met Forman and something else but I never took it I read about the side effects I know he suggested that before but you can get rid of it and you can get rid of high cholesterol very easy you need good fats to get rid of the bad fats and processed food has so much canola oil sunflower seed oil all them that mess you up so much and you’ hormones I’m just trying to help women with menopause probably shouldn’t comment the stuff on here I don’t want to get in trouble but always research yourself the Cleveland clinic I think Harvard and a lot of them colleges on their science website I believe have a Lotta information but you got to do the research I’m gonna wait a little while before I take the supplements I see the movie what time where this man started aging backwards and turned into a baby when that be funny if that happened, I can’t help myself good sense of humor will keep you healthy too PAX PAX 2 months ago (edited) These guys are fantastic and their expertise in longevity is obviously unrivalled. With that said, they are not qualified to talk about testosterone on a public platform. The understanding demonstrated here was woefully low. Testosterone does not cause prostate cancer. If that was true, there would be high levels amongst teenagers and young adult men. Prostate cancer is caused by localised high levels of estradiol in the prostate. This typically occurs due to lowering levels of testosterone and higher aromatase activity as men age. When a tipping point is reached, prostate cancer will occur. There isn’t even any mention of the importance of progesterone, and how it inhibits the aromatase activity of T to E2. Progesterone also declines with age and SHBG which typically increases will also lower Free T. There is so much more to the puzzle that is endocrinology, that to focus on a couple of pieces of it is dangerous on a public platform. Testosterone is incredibly protective against numerous diseases including prostate and breast cancer and Alzheimer’s. It is a shame they have not given endocrinology the same due diligence they give to Longevity studies, because only urologist and endocrinologist dinosaurs would repeat this old tired dogma now. Professor Edward Friedman has a fantastic book on testosterone for anybody interested. Andreas Fragmichselbst Andreas Fragmichselbst 6 months ago I am just surprised why the FDA seems have never big problems with Glyphosate. 1 Pmann Pmann 6 months ago Hello Dr. Sinclair, do you have any opinions on creatine supplementation? 1 Aaron Catolico Aaron Catolico 6 months ago It shouldnt always be strictly quantity of life, but quality of life as well. Some people have serious health issue due to lack of testosterone or hormones as to why they get prescriptions to improve the quality of their lives & possibly even quantity depending on what their health problems were. Having too low of testosterone could cause many types of health problems. 2 Tom Jackson Tom Jackson 3 months ago I would take DHEA,HGH and Mifoerm 5min a in to a ice bath, maybe 7 to 10. Take it when the blood flows back to the core. Mike Graf Mike Graf 6 months ago Do people who "reverse aging" remain dependent on the supplements to maintain that youth? If they stop taking them are the effects rapidly lost, or lost slowly as though they were that lower age? The reason i ask is because true age reversal would mean without taking the supplement you age like someone your age - 10 yrs (for example). Else it's not true reversal, just mimicry and you still have worn out cells. A long while back i heard aubrey de grey talk about how in the future we may actually learn to regenerate youthful versions of our cells so when you make a new cell it might look like a 21 yr old version, not your 60yr old version. Diana Valdez Diana Valdez 6 months ago Love the content! Ty! ❤️ Margaret Bachmeier Margaret Bachmeier 6 months ago Dr Sinclair, Could you Please let me know the Name of the Sleeping Pills that you take. Thank You . Love listening to you. Rosa Della Casa Rosa Della Casa 4 months ago Can gene therapy be used to regenerate healthy liver tissue or turn cirrhotic tissue into healthy tissue for non-alcoholic cirrhosis? Are there clinical trials for this? Where do I find them? manikdesign manikdesign 6 months ago Podcast starts at 5.30 1 Eugene Lynch Eugene Lynch 6 months ago Sinclair doubting mouse data re peptides is rich. 1 French Montana French Montana 6 months ago guys! when are you going to speak about the skin and hair part of all this?!?! you guys mentioned that you'll go into detail with it! please and thanks 1 Rafael N Rafael N 1 month ago So what's the final advice take testosterone, hgh or peptides? Or don't take them? Or takemods? and monitor sides and counter act sides with other meds? Achilleas N Achilleas N 6 months ago Longevity / biotech will be the biggest industry we have ever seen in my opinion 3 Jan Lock Jan Lock 6 months ago I am still wondering... when the cheap test is coming ? Last year you said : at the end of this year. I'm on the wait list but impatient. Have been using a great deal of money for several years and it's all on faith. stephen lucier stephen lucier 6 months ago Brilliant! 1 David Sinclair Erick Minor Erick Minor 6 months ago I would wager that most older adults would rather feel good today as opposed to just living longer. Tom Billard Tom Billard 6 months ago not everybody wants to live longer as in past the avg life expectancy, they just want superior quality while they are here. you also leave out that there are ways to counter some of those side effects Russell Simien II Russell Simien II 3 months ago "Eunich's have been shown to have longer lifespans..." Oh well, so much for living long Judy Fasola Judy Fasola 6 months ago Drs.... love your podcasts ....ok please what water filtration do you use...... I've been doing alkaline filter... pitchers ...heard alkaline is bad ...... I'm 72 years young 😊...on your protacal ...but haven't heard you mention water ...could have missed .....also do you take all vitamins in morning or throughout the day ... Thanks again for your input....💕💕💕 Edgar Diaz Edgar Diaz 5 months ago Taking HCG instead of testosterone will not shrink the testicles, T will go up but won’t work for primary hypogonadism, and won’t work for females orion baden-powell orion baden-powell 5 months ago pretty sure I was told dhea was beneficial for menopause but the mayo clinic says do not combine with estrogen, which I am on, I am also prescribed testosterone Jordan Minnix Jordan Minnix 6 months ago Went on trt at age 26 and i cant imagine going off of it. Low t is terrible. Mario Mario 5 months ago So you start a channel and get over 100k subscribers in one month. That is astonishing! :) But i am very happy about this channel. Aamir Shahzad Aamir Shahzad 6 months ago I have a confusion on when you say long term & short term ... if someone starts TRT at 40 if he feels good for 20yrs what else he will need Camilo Andres Leguizamon Camilo Andres Leguizamon 3 months ago Excellent podcast GoTo Mars GoTo Mars 6 months ago Question David - what about periods of upper quintile testosterone & periods of lower quintile to allow adversity, but also allow periods of feeling better & sports improving? Say 3 months of one, 3 months the other, and so on. This variety is easily done with TRT. Doctor Ni Una Dieta Más Doctor Ni Una Dieta Más 6 months ago Please take a look at Diazoxide neurological and antiaging benefits. 🙏 It's well studied 6 Adam Werderits Adam Werderits 6 months ago At 24 min, with all due respect, Cerebrolysin is actually a brand name and it has several decades of clinical use and research to back it up, it’s not experimental by any means. sahil sharma sahil sharma 6 months ago Doctor do you know know about taatwale baba, he stopped aging when he was 33 and when he died at 90 he was same as he was at 33...he stopped aging. You can contact his disciple who lived with him many years. He still living in his cave. Chris OTC Chris OTC 6 months ago David mentions getting a good night's sleep is so important for stimulating growth hormone, but personally I find with prolonged fasts my sleep gets really disrupted,.... to me, it seems that prolonged fasts and proper sleep don't go well together.. and is less beneficial? Creighton Freeman Creighton Freeman 6 months ago I hope your eye reprogramming human clinical trial progresses rapidly. Both my parents are losing their eyesight to macular degeneration and there is currently no real treatment, only drugs that slow the damage. If your reprogramming Yamazaka gene therapy can do for human eyes what it does for mice eyes it would change lives. Youtube Iscruel Youtube Iscruel 6 months ago "I've been taking athletic greens for a number of years now" Lucas Lima Lucas Lima 3 months ago Oh Jesus! I had to take a break after the mini human brain part!! 35:00 C M C M 6 months ago Do you guys think sitagliptin can be used in place of metformin? Lucas Lucas 1 month ago can you say something about how the fluorine in water affects us? How to Do it by smoon How to Do it by smoon 6 months ago my question is that if we reprogram the cells how do regenerate cells that are lost such as AD disease, do they reprogram the stem cells and they know where to go? Yourcoach Bladimir Santos Yourcoach Bladimir Santos 5 months ago Does anyone knows where david is getting the supplements from? Martin Metze Martin Metze 6 months ago What does the science say about dehydration? Any longevity benefits here? I know its generally bad. 1 Marjake Marjake 6 months ago I am physically disabled and unable to exercise. What can I do to counteract this? Kris Jay Kris Jay 6 months ago are people who are non-diabetic having success in getting metformin prescription? I did a telehealth doctor thing and after the session he says, "we don't do that", despite me informing ahead of time that was the reason for the appointment. fox fox fox fox 6 months ago (edited) Rewatching "Invincible". I was like that's the guy. Lol I think they even said it was a Easter egg. Was an interesting find. 👍 DA Sinclair hahaha 🤯🤣 Though cyborg hybridization seems more in the realm of Elon with nuro link. Funny because Nikola Tesla was featured in the fist superman cartoon. As a mad scientist deathray and all. Though he did actually have plans for one. I couldn't have been the first to notice though. katie obeid katie obeid 6 months ago Plz talk about HRT in future podcasts. Anna Frances Anna Frances 4 months ago Mini human brains = fantastic news for mini zombies (Also for those us us with high predisposition for Alz) Madonna Tolentino Madonna Tolentino 6 months ago glaucoma.. i hope therapy to reverse it be avail soon.. we r running out of time and I am super worried Vega Vega 5 months ago Can you talk about the cjc1295 peptide shots? Thanks Justin Girard Justin Girard 3 months ago What about the elevated GH levels along with fasting? I get confused here Leona Owen Leona Owen 6 months ago How do you get cells from an embryo? 1 Timothy Kowalewski Timothy Kowalewski 6 months ago Idk....people like Sylvester Stallone(at age 75) and his celebrity co-horts seem to be aging just fine on all sorts of performance enhancing drugs which would be labeled abundance mimetics Carystus Carystus 5 months ago At 22:35 the text reads 'thymus and alpha one', it should be thymosin α (alpha) 1. Fatima Freire Fatima Freire 6 months ago 😊👏👏👏👏❤️ Kirill Knyazev Kirill Knyazev 6 months ago David looks a bit younger than in the previous episode) 5 Bird Turd Memes Bird Turd Memes 6 months ago Good podcast, you should redo your animated intro, the music is a bit too loud for a portion of it. bibodude bibodude 6 months ago I'm little bit confused. In fact, in one side, we are suggested to do intermittent fasting which also increase growth hormone in our body. But in another side, we are told too much growth hormone is detrimental for the our body. Can someone clarify this contradiction? 1 Joe Anarumo Joe Anarumo 6 months ago Thank you once again 2 Abdelilah BENAHMED Abdelilah BENAHMED 6 months ago yes, abundance (and money) mimetics is not always a good thing. RationalThinker RationalThinker 7 days ago His looks and appearance proves his knowledge chiggsy in Thailand chiggsy in Thailand 1 month ago So you could live longer but you might get to 120 say and think to yourself, if I hadn't spent so much time dieting,not drinking and worrying about my health I might have enjoyed my life more. 1 Stephen Rushing Stephen Rushing 6 months ago (edited) Look at people that have been on TRT for 20 years vs. those that haven't. There is no comparison. Muscle is metabolic currency and the best correlate to quality of life in longevity, which is more important than longevity itself. This is like looking at a math problem and seeing that answer is the obviously wrong, but saying, "Well, they showed their work..." The work is wrong. I could see 10 years ago that the older people with the most vitality we're on hormone replacement therapy, women included, and basic observation over time confirmed that if I wanted to model after them I should live an active lifestyle (exercise endurance, strength with full ranges of motion/high mobility demands) supported by exogenous hormones (when natural levels decline enough). It's bonkers to deny the obvious vitality difference in these cohorts. Also, the "little known side effects" mentioned are common knowledge in people on HRT and more easily managed than someone on a suboptimal diet. 1 MrMike44v MrMike44v 3 months ago The only thing i dislike about this podcast is way too many ad breaks Brian Adler Brian Adler 6 months ago I assume that DHEA is an abundance mimetic (and therefore not long term beneficial even though it is short term beneficial)? LaDonna Bella Villalobos LaDonna Bella Villalobos 3 weeks ago Play Sinclair I approve inside tracker for sure because you cannot get a decent blood work out from a doctor and they change the range since the 70s so you really don’t know what you are getting at the doctors office Quantitrader Signal Service Quantitrader Signal Service 6 months ago My doctor will not give me a prescription for metformin because I do not have diabetes so I'm taking berberine. From what I've read its just as good. Sunset89 Sunset89 5 months ago I have ordered Athletic greens 7years ago and its still not finished. It just tastes awful Alexander O'Hanlon Alexander O'Hanlon 6 months ago And this has been know for decade's, hence why kids go missing and turn up drained is big buisness. 1 HAL NineOoO HAL NineOoO 6 months ago Is it a stupid idea to save and freeze young blood for one's old days? Our blood when we're young holds a youthful balanced hormonal and immune components that may set the body back to healthier state. Is it sound? Thank you. 2 Shrek Shrek 6 months ago It’s not playing God laddies. It’s just making people’s quality of life better. Joseph Benjamin Joseph Benjamin 6 months ago Does anyone know who provides Biological Age test in Australia? Thanks Matt Gallant Matt Gallant 6 months ago growth only occurs when you are not use to something 🧠🧬 tim kunde tim kunde 5 months ago How about using t cell therapy for lydig cell therapy and replace trt therapy? nasrin salah nasrin salah 6 months ago Athletic green sounds good 👍🏼 steve biggs steve biggs 6 months ago Is there more benefit to using TRT (If monitored and not over done) than not using it? The reason I ask is that I am assuming decreased T is also a major indicator of aging. It seems regarding TRT treatments, you are damned if you do and damned if you don't. Thus, back to my original question, does the benefits of using TRT outweigh the risk? Yayang Tapir Yayang Tapir 6 months ago Today both of you wearing indigo blue??!! .🤔....looking cool....😁 Thanks for another great episode....! Stuart S Stuart S 6 months ago So regarding TRT, how much does it work against longevity? Say my testosterone stays in the 600 range which is middle of the road normal…will that completely undo all my once a day eating and NMN/resveratol morning routine? What would you recommend our testosterone levels be to be in the longevity range? h20no h20no 6 months ago 100 years from now society will look back and say how was he not more popular than a Kardashian. Un-person Un-person 5 months ago Please do a public debate with Brad Standfield. You two are both doctors and oresent conflicting i formation: Pride is not of value: truth is: please let go of pride and have this discussion Ty Yung Ty Yung 6 months ago I had an aortic dissection 2 years ago at the age of 19 during water polo practice. With my aorta still torn 12 inches and is continuously opening would stem cell therapy help reguvitating my tissue? Ivan Islas Ivan Islas 4 months ago good info👏 PlantBased AthleteRealtor PlantBased AthleteRealtor 4 weeks ago Can you do a podcast in HLAB27? Samantha Lam Samantha Lam 2 months ago Can we rejuvenate ovaries? 1 Joshua Eisenberger Joshua Eisenberger 6 months ago i want to try cerebrolysin so badly i heard so epic stuff about this peptide complex its bonkus. But sadly i need an recipe in germany so im looking forward to get it in the netherlands (this reminds me of my weed days :D) 1 AJ AJ 6 months ago whats the best place to buy nad and nmn Rachel Kadar Rachel Kadar 9 days ago What do Dorian, I mean David Sinclair and Matthew LaPlante think of Joe Dispenza's supplements? philip georgiev philip georgiev 6 months ago Kick ass podcasst 1 Jeff Lawrence Jeff Lawrence 4 months ago Any thoughts on gut health & Butyrate? Damian Damiano Damian Damiano 6 months ago "I am not selling you anything", AH Yes its time for sponsors cheekybastard99 cheekybastard99 5 months ago Curious why he's misinforming people about the legal situation about peptides. Gary Hurst Jr Gary Hurst Jr 6 months ago Where can I buy Mots-C? And what brand? Aurora Maria Lopez Reggiori Aurora Maria Lopez Reggiori 4 months ago (edited) And sorry another question which is the name of the chinese study / scientists that are looking to reverse senescent cell with exosome ? Or where I can read more about it ? Piotr Sitek Piotr Sitek 5 months ago this is great Adam Sherlock Adam Sherlock 5 months ago Does athletic greens break your fast? Pamela Wathi Pamela Wathi 3 months ago Can anyone on hrt/bhrt take NMN? Bump Ahead Bump Ahead 4 months ago Their concerns sound like the same THEY should of said regarding COVID vaccine. The sad irony. estilus after estilus after 6 months ago Por favor pueden traducir los videos al español o poner subtítulos? Yo no se ingles solo comentó en español porque ahora YouTube tiene traductor de texto espero que lean el mensajes Saludos SHYLA ANDREWS SHYLA ANDREWS 6 months ago Hi Dr… how can a diabetic fast what abt hypoglycaemia.. how to overcome that? Bobby Boyce Bobby Boyce 5 months ago Ok.. so fasting promotes and raises testosterone and hgh.. so is fasting not good for longevity? Will Frank Will Frank 6 months ago Don't google Teratoma!! Stuff of nightmares 37:13 1 Stand Sure Stand Sure 6 months ago What about Selegiline? Aicul Sunlight Aicul Sunlight 3 months ago I have hypothyroidism & my thyroid is shrinking . Can you please make me a new one ? I really dislike the fact that I have to take thyroid’s hormone for life Thanks Michelle S Michelle S 5 months ago Growth hormone dangerous if you don't know, what you are doing....... As for athletic greens OK if you are rich have you seen the cost of that stuff 1 No No No No 2 months ago So basically the most promosing thing are exosomes. Jana Eriksen Jana Eriksen 6 months ago Bonjour from Switzerland 🇨🇭! Je suis prête 😁 1 LAKK Mentor LAKK Mentor 5 months ago Excellent Euro Pizza Cafe Fountain Hills Euro Pizza Cafe Fountain Hills 6 months ago You didn’t address the fetal stem cells. That’s very different from what you’re saying Pmann Pmann 6 months ago Let’s go! WM P WM P 6 months ago HGH - increase while fasting? Min Min Min Min 6 months ago Please someone answer - I find info, that sauna boost Growth hormone in high levels. Even athletes use sauna to grow muscle. But also everyone here is telling sauna is great for longivity. So frequent sauna = growth hormone - good or bad or what? 1 MiraAI MiraAI 5 months ago Great 🔵⚪🗿👍 1 Ankush Sharma Ankush Sharma 6 months ago awsm awsm..once more David Sinclair Dikeledi Mogobe Dikeledi Mogobe 6 months ago My mentor! The circle Network The circle Network 4 months ago Plz use these secrets for ur face too Albert Cortés Albert Cortés 5 months ago David you look trippy when your reading. Eönwe Eönwe 6 months ago Unix live longer. Dump Windows. 1 Frankie Cal Frankie Cal 5 months ago Joe Rogan Hyperventilating.😵😫😩 1 Support Team Support Team 3 months ago David do you take any of these things you discuss personally? You do look awfully young. Colin Weir Colin Weir 5 months ago What about ESTROGEN blockers doc_ciotola doc_ciotola 5 months ago BPC-157 not BP 🤣 The Shadow The Shadow 6 months ago Well promoting is selling! AJL AJL 3 months ago Can Co-host Matthew please don't hold a pan or even finger pointing to the speaker? This wasn't once, this occurs in every presentation. Its so distracted to viewers and also irrespectful to your host, thanks. Nicole Pazos Nicole Pazos 5 months ago (edited) Athletic greens putting in werk Michelle S Michelle S 5 months ago And you have botox I can tell 👍 1 Little Queen Little Queen 6 months ago And what about women’s hormones?! I love you guys buttt 🙄🙄🙄 3 Raffaello Inigo Raffaello Inigo 6 months ago COOL !!!! Audio Smarts Audio Smarts 6 months ago 18:11 Cody Ray Cody Ray 6 months ago David I just need to know how you have no gray hair? Why and how ?!?! 1 Matrices Matrices 6 months ago What's the cure for the mental state that makes some people want to scar themselves with ugly tattoos? cholakicha cholakicha 6 months ago (edited) 51:30 The Roaming Gnome...Glenn Munro! VRCM/SkyWarn The Roaming Gnome...Glenn Munro! VRCM/SkyWarn 6 months ago (edited) So sugar and protein (glucose) doesn't get along with growth hormone. That leaves abstinence, fasting, or an entire diet based around no sugar or protein. 👽 A no sugar/ no protein diet... James Frith James Frith 5 months ago For the Alg boost Barbara Lanzante Barbara Lanzante 6 months ago I was hoping you Would have spoke of bio identical hormone therapy? 1 كوتش منير كوتش منير 4 months ago Thanks pbalerig pbalerig 5 months ago Inside track is only 20%? Not 25% off?? Pat rick Pat rick 6 months ago You must ask why these things are banned? Hint $ Khalid Raza Khalid Raza 6 months ago Many thanks for that . I pray to Allah guide you to be Muslim. Prophet Noah did live over nine hundred year.(950). 4 RENOWN 55 CHARGE RENOWN 55 CHARGE 6 months ago 😩 These cavewomen though 🥵 chickensandw1tch chickensandw1tch 1 month ago (edited) 24:12 oohhh😎😎😎😎😎 34:00 lol kan s kan s 6 months ago Fashion police says...loose the hat. WM P WM P 6 months ago Why do you need a doctor? PetersonChevy PetersonChevy 6 months ago Too many commercials Terrell Cunningham Terrell Cunningham 6 months ago David. Gimme gimme gimme Dr.Ro3e Dr.Ro3e 3 months ago TNQ! Josie B Josie B 6 months ago I hope you live forever. Just don’t tell Trump about this science. 2 RandomPower RandomPower 6 months ago MATT just keeps talking 3 Cristiany Rabelo Cristiany Rabelo 5 months ago Is facial threads safe? Ayoub Forreg Ayoub Forreg 6 months ago You both lovely (: RandomPower RandomPower 6 months ago Matt is annoying. He speaks in an annoying way. Too many words. Trying to be funny. Speaks too slowly. Struggles to form sentences, searches for words very long even though his part is largely scripted! The dynamic is unnatural because it's scripted. It's the opposite of what a podcast should be like. 2 elena caas elena caas 2 months ago Aqaaaaa Robert Mendez Robert Mendez 5 months ago Who wants to live forever. Postponing the inevitable Nice shirt Nice shirt 6 months ago Bitcoin 1 Jade Zee Jade Zee 6 months ago bad info about testosterone....jeez...where are the things people can do right now? all this guy does is talk about his lab his lab.....RESEARCH YOURSELF PEOPLE RandomPower RandomPower 6 months ago Some one please count who speaks more, Matt or David? 1 rebaked rebaked 6 months ago Forta nemuritorii A.C. A.C. 6 months ago Dr Sinclair ur looks is so pleasing… Sandra Lee Sandra Lee 6 months ago Try raising your camera angle so you are slightly looking up... you will tilt up your chin & forehead in an attractive way. Hans Frankfurter Hans Frankfurter 6 months ago anyone notice David Sinclair has no lips? The Science of Looking Younger, Longer | Lifespan with Dr. David Sinclair #6 462,208 viewsFeb 9, 2022 David Sinclair 209K subscribers In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. The latest science behind various beautifying therapies is highlighted, including newer interventions like low-level laser therapy and platelet-rich plasma injections. #DavidSinclair #Longevity #SkinCare Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair Levels - https://levels.link/sinclair InsideTracker - https://insidetracker.com/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Lifespan podcast website: https://www.lifespanpodcast.com Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsincla... Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclai... Stay up to date with David's work to democratize biological age testing and insights: https://www.tallyhealth.com Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante Timestamps: 00:00:00 Launching Episode Six: Combating Cosmetic Aging & Improving Skin, Nails & Hair 00:02:54 Estrogen, Progesterone, and Menopause 00:09:51 Thanking the Sponsors 00:12:57 The Pinch Test, Epidermal Thinning, and Foot Ulcers 00:18:29 Skin and Biological Aging 00:23:19 Cellular Senescence, Ultraviolet Light, and Skin Aging 00:28:15 Collagen, Keratin, and Skin Health 00:33:38 A Quick Aside about Nails 00:34:45 Autophagy and Retinoids 00:36:57 Resveratrol, NAD Boosters, and Hyaluronic Acid 00:41:44 Botox, Skin Peels, and Microneedling 00:43:28 No Duh Stuff: Sun Damage, Smoking, Alcohol, and Bad Food 00:45:42 Hair Loss and Hair Graying 00:49:45 Topical Treatments, Pills, and Dihydrotestosterone 00:55:19 Frickin Laser Beams: Low-level Laser Therapy 00:57:59 Platelet-rich Plasma (PRP) Injections 01:00:11 Hair Aging, Stress, and Gray Hair Reversal 01:06:11 Targeting Aging Upstream 01:07:37 Today’s Takeaways 01:09:25 Subscription and Support Options Links: Human faces and mortality predictions: https://bit.ly/3rA0tgd Biological age prediction in human skin: https://bit.ly/3LdDZcO Senescent cells and lifespan in mice: https://go.nature.com/3HFO9Rh Nail growth and aging: https://bit.ly/34tnSYb Autophagy is a major regulator of aging: https://bit.ly/3uHh2Jr Hyaluronan and cancer resistance: https://go.nature.com/3HHoyHK Topical tretinoin and hair growth: https://bit.ly/3GCF0rl Dihydrotestosterone levels correlate with mortality: https://bit.ly/3GBFFJJ Eunuchs are especially long-lived: https://bit.ly/3ukL1GU Human hair greying is linked to life stress: https://bit.ly/3J5adVU Grey hair reversal in mice: https://bit.ly/3Li9F0J Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. 1,331 Comments rongmaw lin Add a comment... Fortnite King Fortnite King 5 months ago David inspired me to go to college to study molecular biology and aim for a career in fighting aging because I heard of him from the podcast he did with Joe Rogan in 2019. Thanks David! 645 Cheryl R Leigh Cheryl R Leigh 5 months ago Here are the timestamps which I swiped from the show notes: 00:00:00 Launching Episode Six: Combating Cosmetic Aging & Improving Skin, Nails & Hair 00:02:54 Estrogen, Progesterone, and Menopause 00:09:51 Thanking the Sponsors 00:12:57 The Pinch Test, Epidermal Thinning, and Foot Ulcers 00:18:29 Skin and Biological Aging 00:23:19 Cellular Senescence, Ultraviolet Light, and Skin Aging 00:28:15 Collagen, Keratin, and Skin Health 00:33:38 A Quick Aside about Nails 00:34:45 Autophagy and Retinoids 00:36:57 Resveratrol, NAD Boosters, and Hyaluronic Acid 00:41:44 Botox, Skin Peels, and Microneedling 00:43:28 No Duh Stuff: Sun Damage, Smoking, Alcohol, and Bad Food 00:45:42 Hair Loss and Hair Graying 00:49:45 Topical Treatments, Pills, and Dihydrotestosterone 00:55:19 Frickin Laser Beams: Low-level Laser Therapy 00:57:59 Platelet-rich Plasma (PRP) Injections 01:00:11 Hair Aging, Stress, and Gray Hair Reversal 01:06:11 Targeting Aging Upstream 01:07:37 Today’s Takeaways 01:09:25 Subscription and Support Options 240 Dona Hileti Dona Hileti 5 months ago Thank you for your very interesting podcasts. I was delighted to hear that this episode will be on HRT and womens ageing. Sadly male boldness took central stage. Please please please present an episode dedicated to menopause. Most doctors are not trained in menopause and the whole world acts as though it does not exist… 400 craig hough craig hough 5 months ago The final “episode” of my moms life, the one that shut her body down, was thin skin. It kept tearing and then wound care, etc. and on and on. She slipped of a stool and ripped her skin. She died 3 days later, obviously many mitigating factors. But for 5 years she suffered from tissue paper skin. Good to hear someone finally wants to address these seemingly minor issues of aging that are far more serious than people realize. 83 Audio Smarts Audio Smarts 5 months ago 28:22 Keratin & Collagen 34:50 Retinol and Retinoids 55:30 Low level laser therapy 58:15 Platelet rich plasma Gdf15 - Hair growth gene Tretinoin - Medication used to treat acne and sun-damaged skin 189 Siam Siraji Siam Siraji 5 months ago (edited) Dr Sinclair has been an inspiration for me. I have heard of him back in 2018 for the first time, since then been following all of his work. Now, this year I will be graduating from the dept. of Biochemistry and Biotechnology. Currently, I am working on one of the sirtuins genes. All because of Dr Sinclair. You made this young boy dream big. I just turned 23 this year. Haha.. and I have decided to pursue this longevity field. Thank you wholeheartedly, Dr Siclair. 127 Dr Kaushik T Dr Kaushik T 5 months ago As a doctor, this is one of the very few podcasts I genuinely look forward to 117 French Montana French Montana 5 months ago okay great podcast and thanks for it. however it sucks that you guys never really got into exact detail of what you should and shouldn't eat / do for hair and skin? do we workout more? so we fast? do we go in saunas? do we take cold showers? and good too, do we eat or more greens? more eggs / biotin? do we eat less carbs and sugar? wish we got those answers. 47 Nicholas Arapis Nicholas Arapis 5 months ago My new favorite podcast! Hope you keep it going after 8 episodes. 76 Tracey Leigh 1111 Tracey Leigh 1111 4 months ago I love this podcast. I am almost 53 but feel 33. And apparently look more like 43. Vegetarian, yoga and meditation has been good so far but this is amazing information. I was a late parent. To know I have to power to live long enough to see grand kids grow up is amazing. Thank you both for all that you do. 🙏 And I love the humour. 🖖 😆 Aussie Gratitude being sent your way 🇭🇲 36 cailllou25 cailllou25 5 months ago I've been using tretinoin daily for the last 20 years, since I was in my early 30s. I'm 50 now and my skin looks better than it looked when I started it. I don't see any side effect or accelerate aging, at least not yet. 56 Kelly Sober Kelly Sober 5 months ago I have been following David’s work for about 2 yrs now. Thank you for addressing women. You do have women listening. It does seem like women get left out of the coversation, out of research and their health issues (like autoimmunity) don’t get money and attention. It does feel like wr are second class honestly. 38 Little Queen Little Queen 5 months ago Hey! I was one of the females that commented on your last video about leaving us out. I wanted to say thank you for addressing some of the issues surrounding female hormones and menopause. 😌 You guys are awesome 👏 👏👏👏 95 Dave Oatway Dave Oatway 5 months ago Great show. I have been using 1-Skin for a year and have noticed a difference in my skin. At 77 years old, my Pinch Test is very quick. I started taking NMN 3 years ago and noticed my hair getting brown again. This is increasing. Now I take 2 gm of NMN most days (i figure I am older and need all the help I can get) and walk 5-10 miles almost every day, with some HIIT. I'd be very interested in an update on Dr. Sinclair's father's journey. These shows are excellent - much better than many interviews with often clueless interviewers. 34 C M C M 5 months ago PLEASE do an episode on fertility for both men and women. I’m suffering from recurrent miscarriages and I would love to have some literature interpreted into layman’s terms. 25 Julia Rawsome Julia Rawsome 5 months ago Looking forward to this podcast 😊 I‘m on a plantbased diet since over 10 years (including a high amount of raw foods on a daily base). I noticed that my body sticks to to the same weight for years. I rarely feel tired/sluggish during the day and my hair is growing better at 40 compared to my 20s. Also I eat within a 6-4 hour window. Just be your own project and see what works for you 62 Rebecca Crawford Rebecca Crawford 5 months ago I would love to know what kind of products Dr. Sinclair personally uses on his skin. And I was really hoping cellulite was going to be addressed in this episode. 31 Kaya S. Kaya S. 5 months ago Fascinating episode as always, guys! I was wondering if there’s any information regarding these ‘plant stem cell serums’ that I’ve noticed popping up in the cosmetics sections? Any validity in those, and if yes, what would be the science behind them? 17 Panda1122 A Panda1122 A 5 months ago Thanks for this. My mom has used retin-a since she was about 25. She is over 70 now. No skin cancer or other crap…. Her skin rocks!Very incredible info. Lots of love ❤️ 22 Crazy Farmgirl Crazy Farmgirl 5 months ago I am thankful for your podcast i am trying to soak up all the health and antiaging information i can. So that i can age well, both physically and mentally. I want to be an old person who can take care of themselves and have a full active life not requiring aid from others. 19 Xela Klement Xela Klement 5 months ago Thank you SO much for these podcasts. I look forward to them each week! You manage to be factual and informative while still keeping it interesting and even funny (had to laugh quite a few times) I was also wondering if anyone knew if these sponsors are also available in Europe or if there's something similar available on the old continent? 11 Cat Steinhilb Cat Steinhilb 5 months ago Thank you!! For finally addressing women’s hormones, particularly Menopause!!! 17 Lis Engel Lis Engel 5 months ago Interesting talk - I am 78 - and for some time I started eating 90 % whole food plants with Greens, beans, onions, mushrooms, nuts, seeds, berries and what I have observed is that my nails are getting stronger and that they grow faster 😊🍀💚🎶 19 AD BC AD BC 5 months ago You are helping so many people improve their health! Thank You! 🌀💚🌀 19 E. MB E. MB 5 months ago Thank you for addressing this for women. I'm in estrogen, testosterone and progesterone and I feel great, lost some body fat and my mood improved drastically; but this is something my MD or OBGYN don't want to treat. I'm doing it outside my network and it's very expensive. 52 thatstheguy07 thatstheguy07 5 months ago David reminds me of that friend who got stoned for the very first time and when they talk they have this look/smirk on their face where they’re about to burst into laughter over absolutely nothing at any given moment 😄 12 Mr RoNi Mr RoNi 5 months ago Wow. It's becoming one of my favorite podcast series. I'm not gonna miss anyone. Keep up the good work and keep up educating us. Take love. 11 Critical Mass Film Critical Mass Film 5 months ago Using my red/infrared laser light while I watch this on my head and face. It's really helped me with my brain fog left over from having COVID a year ago 10 Ceci Palacios Ceci Palacios 5 months ago As always a great conversation! Since I do not use gloves when I am around my kitchen I thought that doing the skin fold on my hands would not be a good indicator so I did it on my foot and the difference is day and night. This considering that Skin’s thickness is so much alike.. 6 Mark Voelker Mark Voelker 5 months ago Yes, but for both Centenarians and Centurions, the salute "We who are about to die, salute you!" is meaningful. 8 Chris Chris 5 months ago I was wondering for a while why some of my greys returned back to its regular colour, the explaination of it being stress induced and environmental makes a lot of sense 9 Erick Oberholtzer Erick Oberholtzer 5 months ago Thanks for the great content! I've read the book, but every podcast episode I take at least a few more little tidbits of new knowledge with me. 5 eva eva eva eva 5 months ago Thank you so much for giving us so precious information! I’d like to ask about hair loss. It happened to loose most of my hair volume due to chemotherapy for breast cancer. I was given actually taxotere that proved to be quite toxic for my hair follicles. Is there any treatment or any hope of treatment according to breakthrough science or is it considered to be the same as genetic alopecia? 1 Maria Land Maria Land 5 months ago Thank you for mentioning microneedling. I work with a similar technique with tattooing equipment to restructure scar tissue. The pain really depends on the area, depth and in women sometimes depending on what part of their menstrual circle they're at their pain threshold. 28 Katie Miller Katie Miller 5 months ago Thank you for doing this podcast! Best one out there! Thank you for addressing women. We get left out a lot in the longevity podcasts and research. 16 Be Strong and Love Yourself Be Strong and Love Yourself 5 months ago I keep pinching my hand now 😄 Thank you for this very interesting and useful episode! 🥰🥰🥰 I will try to be more careful with my Tretinoin treatment, I didn’t know that in a long run it might have negative effects. I love your podcast!!! 💖💖💖 6 Michael Velvet Michael Velvet 5 months ago Wish there was a “Love” button. I love this show and I love your work Dr. Sinclair. Much respect and love for this content. 19 Simon Foo Simon Foo 5 months ago Thank you for sharing the sciences behind aging and possible pathways to reverse or slow down the process. 2 Marlee Robertson Marlee Robertson 5 months ago Dr. David, thank you for your work and willingness to share! I’m sure this doesn’t come with a quick, easy answer - do you have research pertaining to people dealing with issues like histamine intolerance/mast cell activation syndrome? I’ve wondered if some of the products you talk about would trigger reactions in these folks. Thanks again! 3 Lyla N Lyla N 5 months ago Thank you Dr David. i’m your biggest fan and i loved the life spam book that i reread it every once a while. I found your book calming and your voice is also calming. I love learning such great things from you and the best thing is that ur voice is healing 2 Abood Cohen Abood Cohen 5 months ago So glad I found this podcast early in life, very thankful for both of you! 30 Rapamycin News Rapamycin News 5 months ago Thanks for the podcast. David mentioned that a few people are taking rapamycin working closely with doctors, but there are actually thousands of us using rapamycin with good results. Its now easy to get prescriptions and to purchase this low cost generic drug. 2 Taís Monteiro Taís Monteiro 5 months ago Best podcast so far! Thank you so much, Dr. David Sinclair! 10 Jason Stanley Jason Stanley 5 months ago Another hugely exciting podcast. I've turned off my movie channels and am rewatching this entire series and taking notes for my evening entertainment and education.Thank you. Michael James Squires Michael James Squires 5 months ago I enjoy every podcast that you do, keep up the great work mate 🙏 laurie gaudio laurie gaudio 5 months ago This sounds amazing. I know this is a great calming and healthy practice for the mind and body which is especially needed since COVID. 6 19Jetta 19Jetta 5 months ago I have been on NMN and resveratrol for a little over two weeks now...and it is working. I track my blood pressure and blood sugar most days. Both have stayed stubbornly high over the last few years, probably mostly due to the fact that I have gained weight in the last few years. I am working on the weight but so far I haven't lost...but my blood pressure and sugar are both down. This morning my bp was 118/83 and blood sugar was 98. This is the lowest these markers have been...years. I am excited to see my progress as I lose weight and continue to improve my diet. Thank you Dr Sinclair! 14 Lori Douglas Lori Douglas 5 months ago Why is it always ‘suffering’ through menopause? As someone who’s ‘survived’ I would suggest that it can be seen as a natural transition and a part of graceful aging. 7 Iren Hollo Iren Hollo 5 months ago Dr. Sinclair, as a Hungarian admire your work! A proud Mother of a Harvard Student! Your podcaste is enjoyable... and easy to understand! Please keep it up! Thank you for your work! 4 John Carpenter John Carpenter 4 months ago Dear Dr. Sinclair and Mr LaPlante. First, thank you very much producing the Lifespan podcast. Second, I greatly encourage you to continue the show. The content is intellectually invigorating and practical. It is also hopeful. During a period marked by constant undesirable exogenous shocks, you have offered ways by which we can influence the trajectory of our personal health. I eagerly await season two. Best regards and thank you again, John 1 Claudette Sechler Claudette Sechler 5 months ago Absolutely great! Loved learning about the product knowledge and thanks for breaking it all down! 5 Dr Betty Schueler Dr Betty Schueler 4 months ago I am 78 and it takes 2 seconds for my skin to return to normal but I've been on NMN for about a year now. 2 Megan Wolfe Megan Wolfe 5 months ago Please do not shy away from talking about female concerns just because you aren't women. You don't have to have a uterus to understand the science of how they work! This approach runs the risk of leaving women in the dark. Please address our aging concerns equally. Thank you for the great info. I love your show! 13 Tom Bro Tom Bro 5 months ago Great series! What about sleep and longevity? I hear a lot of different things about sleep. As a triathlete and a person that has run some marathons what is too much exercise? I have cut back and now do shorter runs, bikes and swims as the longer courses training seems to have me pretty wiped out most of the time. Little Queen Little Queen 5 months ago Regarding PRP, this is a very lovely treatment that can be done to rejuvenate the face as well, specifically when mixed with bio-stimulators like Sculptra aka Plasmasculpt ( shoutout to Dr. Rajani-also here on YouTube). But PRF is even better for hair, skin, and bodily rejuvenation. It’s also used in Dental surgeries. The Platelet rich Fibrin has a lot more growth factors and the results are so much better. I’ve had them both done locally. To get the Fibrin you simply spin the blood slower and for a shorter amount of time at the right angle. You then inject the fluid before it fully clots. Once you have a clot you can spread it across the face/scalp and micro needle it in. These treatments are A-MAZING for rejuvenation. 8 C Mickie C Mickie 5 months ago Fascinating. Thank you gentlemen, for sharing your experience with us. 3 Heather Schramm Heather Schramm 5 months ago Thank you for addressing the role of female hormones on aging. 12 crowdancer5 crowdancer5 5 months ago Stopped at 43 minutes to make this statement....I am female at 78 years of age....they took my ovaries about 22 years ago and have been on HRT since....believe me, I have not noticed looking younger...(than what?) but when some doc thinks I am on too high a doseand tries to cut back on them, I go into a total tailspin....physically and menially......I must wonder however, any of the topicals you are speaking of, for someone my age seem silly....I am not hearing you speak of anything other than facial creams....skin is not just on face and neck and I doubt any of us are going to be spending the money on facial cream all over the body to make for healthier skin! I understand this is dealing with "looking younger" but a makeup artist can do that....cmon, give us elders something to really chew on! Nowhere in any of the discussions have I heard mentions of the fact that elders lose much of their ability to properly digest nutrients and thus the body not having the raw material to build healthy bodys...skin and all. The studies are nteresting but can we get down to the nitty gritty here and speak to those of us who are already what society calls old. You so often do speak of male...and in the age bracket of mid life....50s or so....lets reach the elders too! Both male and female! 15 Aicul Sunlight Aicul Sunlight 4 months ago Thank you so much Dr. Sinclair and “lovely” co - host for sharing your knowledge. I have listened/watched/shared your podcast often. I just wanted to make sure I understood. If my nails are growing too fast … does it means that I am aging too fast, or the other way around ? In Hoc Signo Vinces In Hoc Signo Vinces 5 months ago Laser skin resurfacing, which wasn't mentioned, seems to be one of the best current anti-aging treatments out there, working both through hormesis (skin regrowth) and literally wiping out the below the surface senescent skin cells and cross-links (advanced glycation end products). 27 Frank C. Frankenheim Frank C. Frankenheim 5 months ago Great episode, thank you. As I’m suffering alopecia universalis it would be great if there could be any advice about existence of a treatment. 4 kapa0224 kapa0224 5 months ago LOVE!!!!!!!! your podcasts! Thank you so much please keep making them. I listen many times and tell friends who love this content too. Heather 3 Raul Rodriquez Raul Rodriquez 4 months ago Thank you David for all the great work you are doing for mankind. God bless you and the work you do. 🙏🏽 I would like to know if there is anything that can be done to reverse and cure Vitiligo? I’ve had it for about 15 years, but so far have not found anyone dealing with or trying to correct the underlying cause of this disease. All the Best ! 1 Péťa Péťa 5 months ago Just found about you 3 days ago and saw everything on this channel! Can’t wait for more episodes to come. 23 windmill windmill 5 months ago I've often wondered about the connection between scar tissue/collagen overgrowth and normal skin regeneration 3 Marie Bure Marie Bure 5 months ago Omg cosmetic aging is sooo important 😜 I couldn't be waiting more for this one! 11 Melissa Share Melissa Share 5 months ago I enjoyed this podcast and am learning so much through all of your podcasts, so far. I have implemented a number of your longevity protocols and have added a few of my own. I was a little disappointed that you did not address age related bone loss and it’s effects on skin aging in this episode. I have started taking vitamin K2 and Nattokinase as part of my daily regimen. I would be interested if you thought that these could help reverse bone loss? I have heard that K2 helps to guide Calcium produced by Vitamin D3 to the bones instead of the bloodstream and would appreciate your thoughts on this, as well as any other protocols that you would recommend for bone loss. Thank You for sharing your knowledge! 14 Keira_IAM Keira_IAM 4 months ago People often tell me that I don't look my "age" (in my 50's). I pay attention to eating (organic, mostly vegetables) , exercise regularly, don't drink alcohol, don't smoke, take supplements and use organic skincare products. David Sinclair speaks volumes of truth for anti-aging in this video and appreciate his scientific logic. 1 Merav Rosenberg Merav Rosenberg 5 months ago At last. I have been waiting to hearing you about this subject. Thank you. Looking forward for more episodes regarding women in general menopause and hormone replacement therapy. 3 Ashley Wessel Ashley Wessel 5 months ago Your personalities compliment and play off each other very nicely. Great conversation and info, thank you guys 1 Cheryl Simon Cheryl Simon 5 months ago Thank you for this video! Curious if there's any data on negative effects on lifespan from Botox? You're the best! 4 Patti Patti 4 months ago (edited) Dr. Sinclair looks really young for someone who is 52! I was watching his interview with Lewis Howes and it was really inspiring! I feel like it's something to do with our hormone change that age us as we get older 1 Simsam Malinao Simsam Malinao 5 months ago Good conversation. Much thanks Dr. Sinclaire and Matthew. 3 Sal Agnello Sal Agnello 5 months ago I’d recommend staying away from those heat treatments for maintaining facial collagen, after I did 3 treatments I noticed looking much older, not younger. It was a huge mistake, I looked a lot better before the treatments. Everyone used to think I was in my 30s and after only 3 treatments everyone added 15 years to their guesses.Needless to say I’m really depressed over this and don’t know how I can reverse the damage. Any advice? 4 Maria Christine (Websites & Online Business Tips) Maria Christine (Websites & Online Business Tips) 4 months ago Great Podcast! Just a question: Doesn`t hair loss also have to do with acidosis/ hyperacidity? In that case it would have a lot to do with what you eat or drink... 1 Unknown Unknown 5 months ago (edited) I checked one skin brand that you were saying for one it is too expensive and number two i checked the ingredients, there's not much of a star ingredients. Retinol is still the gold standard. And your eye brow is not moving. Did you had botox. 3 Pete Pete 5 months ago Dr. Sinclair, is there any way you can influence InsiderTracker to lower their prices? It would be great to make that test more affordable to all (the margins seem extremely high). 11 Gloria Gloria 5 months ago ITS REMARKABLE HOW DR SINCLAIR HAS STAYED SO POSITIVE AFTER ALL HE HAS GONE THROUGH TO ME THIS IS ONE OF HIS MOST HELPFUL MESSAGE 6 Achilleas N Achilleas N 5 months ago I’m actually considering changing my career as I didn’t realise ageing was something science and engineering could solve - I want to part of the effort to supercharge the solution 6 Sunshine City Personal Training Sunshine City Personal Training 5 months ago Great stuff! I am really enjoying these podcasts Stephie Getsit Stephie Getsit 5 months ago (edited) I use collagen and alpha hydroxy acid supplement form ,nuvage red light and skin lifting device, love it, my Malaysma basically all gone, AOR estrogen adapt (1/3 the recommended dose full and half does was to strong ) and plant based progesterone cream and a gall bladder support . 54, zero hot flashing or menopause issues now. Although no menstruation and happy that's not showing up. Weight lifting clean diet. And I have zero medication. 2 Mystik Rebel Mystik Rebel 5 months ago A very interesting and educational discussion totally worth the time 2 NMN Anti Age supplement NMN Anti Age supplement 5 months ago Great talk, thank you for your work as always! 2 kitty murrah kitty murrah 5 months ago Dr Sinclair, I have been following you for about 3 years. Your knowledge is so impressive and hopeful. I have learned so much!!! Thank you 11 Sunshine H Sunshine H 5 months ago Thanks for the awesome sharing! Dr. Sinclair, have you studied on dandruffs? Babies don’t have that but many adults do. 3 Aaliyah Lee Aaliyah Lee 4 months ago Thanks to Dr. Sinclair. I've always loved his videos. It's through him I learned about the benefits that NMN provides. Because with age comes with health issues. When you reach about 60, you often need major medical attention. But ever since I'm taking the vitruvin NMN supplement, it changed my life and the way I live everyday! 2 Les Les 5 months ago (edited) 0 seconds ago I have been looking at the "longevity community" for any answers on menopause. This is the closest I've heard yet--and it wasn't very illuminating. Menopause is taken so lightly, even joked about, in our culture. I could barely go to work because I couldn't sleep....I was an emotional wreck, no energy to work out, I thought I was losing my mind. It infuriates me that half the world has to suffer through hell.....very little studies are ever performed on women's health. I've been on HRT for a year now and it has saved my life. 2 Jeff Nixon Comedy Jeff Nixon Comedy 5 months ago Black coffee and Sinclair podcast... the new Wednesday morning ritual 14 The Health Edge The Health Edge 5 months ago Don't look into the centrifuge with long hair! It will definitely be messy. Great , as always. Near infrared light and red light with well established photobiomodulation mechanisms with respect to skin-system health. e.g. type 4 collagen production, protection from UVB exposure, 4th phase of water bioenergetics, mito function (via cyt-C-oxidase up-regulation. and other pathways), etc. Skin, as the largest organ, with the greatest surface area, is best suited as a complex "photo-receptor", translating the EM-biophotonic environmental conditions to the biologic systems they protect. Grateful thanks for your sharing so generously. 2 The Night Time Cook The Night Time Cook 5 months ago I love this podcast and your book. Thank you. I know you do not promote products, and you have given some markers of how to choose a good supplement (like GMP stamp of approval). Can you provide any more information on how to choose quality products, topical and otherwise? 4 Beach Town Stitchie Beach Town Stitchie 5 months ago (edited) Great video. Thank you so much. The thing I find confusing is the idea that thin and smaller people live longer. But, I’ve had both my Primary doctor and my Gyno tell me at 60, that I was getting too thin, and to “be careful”. They said that if you get really sick, being too thin can be bad, because your body has no fat stores to draw from, and also the increase of osteoporosis in older thin women. I’m 60, and thin, but not underweight thin. 6 senseofwonder senseofwonder 5 months ago Thank you for these podacst videos! You are so amazingly generous to share this with the world. 2 Olivia Miller Olivia Miller 4 months ago NMN demonstrated multiple benefits such as fighting muscle degeneration in elderly men and women, aerobic capability, and increasing endurance. The results may vary from person to person. Personally, it has been my 3rd month of taking NMN by vitruvin, that's 500mg, and I love how it worked impressively. I wish many people would give a shot in taking NMN and start living a happy, balanced, and healthy life as they age! 2 Shasha8674 Shasha8674 5 months ago I agree...find out good levels so you can copy them later, but my progesterone was low due to stress at my job and gluten. My levels were not perfect. Progesterone/Vit B12 helps the bones/myelin/thyroid/stress/immune system. Electrodermal tests/hair tests are great help. Genova tests are for hormones/allergies/nutrients/mitochondria. Ulcers/Diabetes/low thyroid/hair loss etc.. can be due to gluten. Gluten is in wheat/barley.rye...oats/corn/rice. Rice is low in gluten. Wild rice has no gluten....is a grass.. Ozone treatment can help clear up infections fast. Starch/sugar/low Mg may cause glycation wrinkles. Mg helps make insulin. Asian diet may help people heal and have a long happy/healthy life. 2 Lucy Cooper Lucy Cooper 5 months ago How exciting that our ailments will no longer be dismissed as the “normal part of aging” at the doctor’s office. 4 Bernard Sadowski Bernard Sadowski 5 months ago Excellent series!!! Please let me know if you need a model/patient/for clinical studies in whatever levels. I am a lifelong advocate of skin and hair care. I would love to talk with you about my lifestyle. A life extension customer as well. Long Island/Ft Lauderdale resident. Bravo to you! 1 Yayang Tapir Yayang Tapir 5 months ago It's huge one..!.. thank you for educating us on epidermal thinning....you guys are in a mission to change our age old beliefs and make all the folk lores about staying young like vampires minus blood sucking come true....🙏🙏 3 Zvezda Colman Zvezda Colman 1 month ago Thank you David! Addicted to your podcasts. So informative, educational, practical, interesting, exciting. And super helpful! And lots of fun as well. Just great stuff! MsKaterinaKo MsKaterinaKo 5 months ago David in all his interviews lately has looked glowing, is it some special skincare or his antiaging lifestyle? Asking as it's relevant to this video! 2 Sanchez Sanchez 2 months ago Love these interviews so much! Gives me a lot of motivation to stay healthy. But does this form of diet is applicable to kids unter 5 as well? I mean, as I understood children should grow, so it would not be healthy to slow growth, right? Steve Reizes Steve Reizes 5 months ago all the knowledge and health benefits aside this is just top quality podcasting! would love to see you both having guests and taking this even farther <3 2 Del Camino Del Camino 5 months ago I wish Huberman lab podcast was as funny as yours! Thank you so much! Both podcasts are life-changing for me! 5 Liana - Holistic Intimacy Coach Liana - Holistic Intimacy Coach 5 months ago I so hope we approach hair thinning alopecia in women. This one I've had since 18... It was my nightmare. No matter what I tried, it wouldn't work. Maybe there's something new here that works for me. 🙏 10 JonnyD000 JonnyD000 5 months ago (edited) Regarding episode 2 about eating, how would you manage to keep up your at home diet habits if you were on an extended trip 3+ months traveling? And how does the 1 meal a day mix with workout days where the exercise will likely make you hungrier? Lea DiMento O'Brien Lea DiMento O'Brien 5 months ago (edited) I am 58, no cavities, no fillings, my hair is very dark brown and lustrous, i don't and never had to dye my hair, my eyes are the age of a 30-40-year-old my doctor told me. I only have a few gray hairs, my fertility was high right up to 55! Not much for wrinkles. bones are good, skin is good, what I use is a face gadget that vibrates as it cleans. VIBRATION from what I read vibration is highly effective. The secret is I don't do cr*p to my body. no botox, none of that. Just grateful for what I got . As I am listening to this I had NO issues with menopause. My memory is sharp, I'm very active cuz I LIKE to be active. Perhaps because I'm IRISH I like to lift weights. That is a big tip. weight lifting. Bicycling works for me and going to the BEACH set me right. Bragg's Apple Cider Vinegar with Cinnamon is beneficial. OXALATES DID do something to my body. a while ago I made spinach, carrots, onion, celery soup with pasta elbows and used the water the veggies were cooked in for the soup broth. that I suspect created kidney stones. Unbeknownst to me especially spinach is high in OXALATES. Who knew eating right could do damage to your kidneys. please research OXALATES in your lab. With everyone drinking ALMOND MILK more people are going to damage their kidneys from drinking it. Almonds are high in oxalates. My skin pinch test went down in 2 sec. I use COCONUT CREAM for coffee etc. 8 Cristina Lusardi Cristina Lusardi 5 months ago PUEDES PONER TAMBIÉN SUBTÍTULOS EN ESPAÑOL, PARA MILES DE HISPANOS QUE QUIEREN ENTENDER TODO LO QUE DICES. 4 Juan Pablo Aranovich Juan Pablo Aranovich 4 months ago Sharing my notes. I posted this on Medium as well for your convenience (easier to read) You can find the links in my profile You are as old as you look The skin is the largest organ in the body. It makes up 1/6 of the entire body weight. Epidermal thinning: as we age, skin gets skinnier. Having thin skin is bad. The skin is the main barrier against intruders. Skin ages faster than the rest of the body because it’s exposed to sunlight. Skin is full of senescent cells. If you delete these cells, you rejuvenate the skin. Collagen is a protein responsible for healthy joints and skin elasticity, or stretchiness. It starts to attenuate at mid-20s. Retinae: boosts the production of collagen, increase the growth of the epidermis, lower skin pigmentation, lower the lipid. Inhibit MMPs. If you use it you get dry skin, so use moisturizer and sunscreen. It is unclear for the long-term longevity. Nails: the rate of nail growth is an indicator of state of aging. Hyaluronic acids: important for plumpness of the skin. HA is involved in protecting animals from cancer. HA is a big chain of chemicals. Botox. Is a toxin. It inhibits neurotransmissions. It numbs the nerves and thus reduces wrinkles. Things bad for skin: Sun. Smoking. Alcohol. Bad foods. Hair Loss & Grey Hair It has a strong genetic component and it is NOT an indicator of aging. Boldness and grey hair indicates you are older. Evolutionary speaking, this was a great thing because you were seen as more wise and dominant. This was a sign that you should be given respect. Why hair loss occurs? Stem cells important for hair regrowth get kicked out of the hair follicle. Treatments for Hair Loss: Topical treatments: minoxidil works. Stimulates nitric oxide production. Pill: finasteride. It inhibits DHT. However, DHT too low can be bad for health as well. Fricking laser beams: Low laser light therapy. Slow down hair loss. Platelet rich plasma injections. Grey Hair: Associated with stress. It doesn’t have to be permanent. Grey hair is reversible in the early phases. Fun fact: Eunuchs live 15 years longer than average men. Cutting your balls off is the best strategy for longevity LOL. Twitter @Juampiaranovich you can find me and the article. 1 Tina Caruselle Tina Caruselle 5 months ago Great information! I do have a question. If the body going through periods of stress can make hair grey, how does it improve longevity? 4 AmazonianPower AmazonianPower 5 months ago Great conversation! I have a question for Dr. Sinclair. It's about microneedling. Some say that even though there are positive results short term both for hair and skin there might be negative effects long term, so I would love to know what is your opinion. 3 Elena Christofides-Georghiou Elena Christofides-Georghiou 1 month ago Just watched this today! Very interesting! On the topic of grey hair, I wanted to let you know of an example that some medications have the effect of restoring hair color! My best friend's dad was in hospital receiving haemodialysis treatment for his kidneys 5-6 times a week. He was 78 years old and his hair before the treatment was grey all over! After a few months of treatment his hair had become brown, as it was when he was young! All of it! It was a shock to see him after a few months with brown hair! I don't know what the medication he was being treated with was but it sure worked well on his hair color!! :) Lisa C.H. Pillmore Lisa C.H. Pillmore 5 months ago In keeping with your discussion of taking baseline readings of hormone levels before peri menopause begins, I’d like to suggest that a baseline DEXA scan be performed routinely. There is evidence that much of bone loss may occur during pregnancy, as the fetus demands calcium from the mother. It would be good to know how much bone is lost before the decline in estrogen really begins and to address it prophylactically.. Everything Gutter Everything Gutter 5 months ago The key to visual aging is organ knowledge 🙌 3 Danas Danas 4 months ago Loved the detail here. There was one part that was left hanging tough, which is whether these smaller HA molecules actually penetrate the skin and have a positive effect. Is there any evidence that topical HA works? Ligia Sommers Ligia Sommers 5 months ago My favorite podcast , and I listen to many !!!! 🙏🏻✨🌹 Noreli Franco Noreli Franco 5 months ago David, can you talk a bit about the laser hair removal and its effects on skin aging? It sounds counterintuitive but maybe there is something in the medical literature I haven’t heard of. Thanks! Great series! 6 Lisa Ray Lisa Ray 5 months ago I do PRP on my face and it’s been a game changer. I use it in conjunction with radio frequency microneedling. Eva Eva 13 days ago (edited) " The Ordinary " is a cosmetic skin care brand that I adore and works wonders. I hope you could try some of their products as they are not expensive , easy to get in most countries and give us your review as they are becoming very popular rapidly perhaps because people see results as soon as first use. I use their vitamine C serum (they have different ones) so I use ascorbyl glucoside solution 12%, and they also have many others for improving the skin. I also use their matrixyl 10% with HA! They do work!!!!! Jay Jay 5 months ago Great podcast! Thank you! I would love to see an episode on arthritis. 4 Sirt1 Sirt1 5 months ago Very intresting, I am specifically thinking about the hair regrowth subject. This made me start on my anti-age journey as a 28 year old active man. Currently I am taking NMN, Fisetin, Quercetin, Spermedin and Hyalronic acid in order to also get thicker hair and better skin. Not sure, but for some reason I still feel a lack of energy and a will to do things. I did a PRP treatment a few weeks ago, but experienced a lot of sudden hair loss, not sure if this comes from the "shock/trauma", and still very unsure if I am going to do the 2nd recommanded session etc. 3 vincent sanzone vincent sanzone 5 months ago Love the show guys, already spreading the word. Also just put in an order for Athletic Greens. 1 JPintero JPintero 5 months ago Melissa55 here on YouTube has used Retin A everyday for 38 years. She looks about 40 and it hasn't hurt her one bit. 3 Strictly Private Strictly Private 2 months ago Prof. Sinclair looks younger now than he did five years ago by well over 10 years. Fantastic!!! Resveratrol and NMN outstanding results 1 Theblond Jane Theblond Jane 5 months ago Love David Sinclair explanation, the facts, his voice and appearance! 3 Amanda Amanda 4 months ago I love this format between the two of you. Rachel Stark Rachel Stark 3 months ago This is exactly what I am telling to my family, especially to my husband who just recently take Vitruvin NMN with me. We imagined how amazing it will be to still hug and kiss our lovely grandchildren when we reach 90. So grateful to this supplement! Thanks to Dr. Sinclair who adds more years to our lives! Julie Welsch Julie Welsch 5 months ago David, I am enjoying your discussions and look forward to getting younger. Will you be able to rejuvenate bones in people with osteoporosis? 3 Yurie Naito Yurie Naito 5 months ago Regarding hair growing longer in places like ear after certain age, I heard that it happens because the body 'forgets' about the growth and fall cycle. 5 Samreen Fatima Samreen Fatima 5 months ago Hi David, Can you expand a bit more on Infrared light lamps people are talking about so much all around? Are there any real scientific benefits of it? 2 Jason Tillery Jason Tillery 2 months ago Love your videos. Is it possible to provide your personal list of supplements along with where to get them at the highest grade or processing standards? Thank you thank you 1 diman585 diman585 3 months ago Very insightful and interesting discussion. I am curious what percentage of your lifespan you can actually control with medications, diet and physical activity. For example, my grandpa is 94 right now, smoked in his 40’s then had a heart attack and quit per doctors reccomendation. He literally ate all the things that are known to humans as bad: sugar, salt, fat, etc. Granted, all of his arteries are clogged now and he’s not feeling great, but at 94?! So one thing that is very apparent throughout his life is that he was always on the move, constantly moving, walking, and rarely sitting. He often laughs when I check nutrition labels for cholesterol or sodium, saying exactly that: I enjoyed my life to the fullest with no limitations, so why restrict yourself now when you don’t know if you are going to wake up tomorrow? 🤷‍♂️ Can’t argue with that logic... Meglovestocook Meglovestocook 5 months ago Hi David, Just discovered your channel and I am already a fan after watching a couple of your videos. I have been intermittent fasting for years but have gotten mixed advice on what is truly considered fasting? Some say anything under 50 calories will keep your body in a ketone state as other have said you can’t even have coffee because your stomach has to digest the antioxidants and enzymes. Can you set the record straight for many of us fasters out there? Much appreciated thank you! 1 Ellen Ellen 12 days ago I went through menopause at 50, and started taking estrogen and progesterone. Now that I'm 66, some health issues that seemed related caused me to see an ob/gyn doctor. She immediately and completey took me off of the HRT and was sure I had cancer of the uterus. After a biopsy showed I did not, she still doesn't want me to take it anymore. It's been about 6 months now and I'm aging at a frightening rate. My skin is wrinkling (it wasn't before), I have dark circles under my eyes, often puffy. I feel hopeless at this point. That is why I came to listen to this podcast. Dorothy Taylor-Dasilva Dorothy Taylor-Dasilva 5 months ago Never heard of a skin pinch taking so long. At 67, mine is still less than 2 secs. Used this to assess hygration/dehydration. 4 Reshad Unchained Reshad Unchained 4 months ago Imagine, having more time with your loved ones as you all age together. Science applied to a true human need. Julia K Julia K 1 month ago I enjoyed this talk very much. Dr. Sinclair is clear and thorough. The interviewer is excellent as well. I had all my questions answered. Thank you! Harpsickle Harpsickle 5 months ago So, if I understand correctly based on your overall podcasts and interviews. You plan on creating a pill that will reverse your aging? Will this reverse your aging to a point that you can still eat and live life like normal? Or do you need to eat and live the strict life style as well? Kate Wilson Kate Wilson 2 months ago For the last few months, I've been taking one tablet each day of NMN-Vitruvin Health supplement. I'm astounded to discover that my metabolism now functions as well as it did when I was a younger. Other outcomes aren't nearly as visible yet, but I saw a significant boost in energy and concentration. I'm going to order another few rounds from their website. It took around just 3-4 days to see a difference. Colleen colquhoun Colleen colquhoun 5 months ago (edited) Great! I’m 61 and just had co2 Lazer done to my face … to help heal … she did PRP INJECTIONS INTO THE SKIN where she was aggressive and rubbed into the skin of the face then ended with red light therapy 20 minutes …just to let you know this is happening out there to the skin not just the scalp I do have an led Red light mask at home … I exercise every day for the last 40 years and I recently started fasting 1 1/2 years ( I try to lower my carbs ) So I’m feeling good and I love hearing about Dr Sinclairs studies … feeling healthy at 61 ! Thank you for all of the questions and answers Ps lost my period I. My mid 30’s so I’m working harder than most …. Haha Iqbal Zaidi Iqbal Zaidi 5 months ago David I have always been your fan. I am a retired senior Canadian in my 70s. I have complied 12 tips to lead a happy n healthy post retirement life. My first 3 are Money, Appearance and Health. I fully agree and believe that keeping appearance young looking fresh adds years to life. I spend lot of money on my appearance like good branded clothes perfumes shoes etc etc and think that it keeps me young. 3 Max Jk Max Jk 2 months ago Hello Prof. Sinclair, thanks for your Work and Curiosity in this field and that you share it with us! I have learned a lot by watching your Interviews and Podcasts and reading your Book. Do you know about any scientific Data about the Effectiveness/Harmfulness of Face Massage by Vibration regarding looking younger? Patti Reznik Patti Reznik 5 months ago Another very interesting podcast. Kudos! 1 rumana nasser rumana nasser 5 months ago This is my favorite channel on YouTube. I’m so thankful for your videos! 4 Benjamin Buemann Benjamin Buemann 5 months ago I watched your latest video with great interest. With regard to skin aging I would like to draw the attention to the anti-senescence effect of oxytocin on dermal fibroblasts documented in the paper British Journal of Dermatology (2019) 181, pp1216–1225. This peptide has also been proven to posses regenerative properties on different mucosal lining in several studies. I believe that if a proper vehicle making oxytocin penetrable through the skin it may be feasible to develop an effective anti-aging skin crème. 1 Ouakour Rajae Ouakour Rajae 5 months ago Thank you Doctor l want to share with you i ve been very sick for years but since i ve been aplying some essential oils on my skin it helps me a lot the pain is gone my skin is better and my hair becomes darker. 3 Sprintlane TV Sprintlane TV 5 months ago New Subscriber from the Philippines🇵🇭🇵🇭🇵🇭🇵🇭 Thank you fir your informative and free knowledge you are sharing to mankind. More power to your channel 3 ted farmer ted farmer 5 months ago Hello, interesting conversation. I am especially intrigued by the hair loss portion of your talk. I am familiar with DMSO, but I’m quite surprised that you mentioned putting it on scalp, many doctors say it’s toxic, however my herbal doc has told me to use it for back pain. So I guess my question is,…. Is it safe to put this on my scalp, since it’s so close to brain. You also mentioned retinol, ….. would you put DMSO with it to help drive it into scalp? If so what formula of retinol would you suggest? Both seem harsh. Levon Darratt Levon Darratt 5 months ago Matthew is amazing! The intelligence of questions, and follow-up points is incredible!!! 4 Kunal Singh Rathore Kunal Singh Rathore 5 months ago (edited) Let’s Go… It’s time to upgrade, to elevate and to be better. 6th episode for the 6th week of 2022. What a way to begin a legendary start of my new year.. 🥰 10 Beach Town Stitchie Beach Town Stitchie 5 months ago I had really good results from micro needling. But also, with TCA peels. Once a month on each for 6 months on and off. NOT at the same time. 1 nina nina 5 months ago Thank you for address menopause.....would love a dedicated video on this topic from your perspective. 2 Glenda Glenda 5 months ago (edited) Really enjoying this channel. Thx you for making science, data, etc more accessible to us lay folk. Let some of that gray show through tho, David. I promise you, it will enhance your appearance, your appeal hence ... thus your longevity ;-) 4 Ian Driscoll Ian Driscoll 5 months ago Never heard of the LLLT before, seems interesting. Diametrically related, I’m a huge fan of red light therapy in general. Improvements in hair, skin, nails, energy, sexual function, mental acuity/cognition and it has an effect for reduction in joint pain. Of course, it’s not an end all be all type of treatment but it’s easy and relaxing to use, can be extremely inexpensive, and effective. 1 Nessa Nessa 3 months ago I’m so excited, I hope soon that the majority of women can safely have kids in their mid 40’s and 50’s. I think the social impact would be crazy but also for health. ISA BEL ISA BEL 5 months ago Gracias Dr. por toda la información que nos comparte. Sería genial que también los vídeos sean traducidos al español. 2 Leather Bath Leather Bath 5 months ago I’m Australian, and naturally very pale. So set up for failure basically. But, I practiced sun avoidance and daily sunscreen since I was quite young. And then started retinol products in my early 20’s, moving onto tretinoin in my early 30’s. I’m 35, and still don’t have any fine lines. Which from what I understand, is pretty unusual. I don’t use tretinoin every night (maybe every other night), I mix it up with some nights using no actives, just cleanse and moisturiser, or using an AHA in place of tretinoin. And I always apply moisturiser on damp skin. Explorers of the World Explorers of the World 5 months ago thank you for very valuable and useful knowledge, I would be interested in the topic of fertility in women, how to care for it and whether it can be kept Jawad Karim Jawad Karim 5 months ago (edited) Great! Great! Great! Greatest Scientist David Sinclair . I really appreciate your kind help... 3 bigpicturegains bigpicturegains 5 months ago (edited) I find much of this info valuable, so I am grateful for Mr. Sinclair sharing. However, the fear of protein is problematic. Even if true that you could live a couple years longer by avoiding high amounts of protein, what’s the point if we are old weak and frail without enough muscle to have a fulfilling life? 1 Weenie Fred Weenie Fred 1 month ago (edited) I discovered this podcast last week and have been enjoying it very much. One issue I had with this episode was regarding the representation of Dr. Baroni's OneSkin topical cream. Because I trust Dr. Sinclair, I got excited about the product and almost purchased. Luckily, while at the website, I read the cited study literature. In it, Peptide 14 (the control/main active ingredient) was found to be significantly more effective than retinol - great news, right? The only issue was that the type of retinol tested was not disclosed, nor was the concentration. This was not disclosed anywhere in the results or the methods, which is unusual when doing a comparison study which presents graphical data. I found this to be very unprofessional and scientifically disappointing... And I wish that Dr. Sinclair would not have stated that the OneSkin product is as effective as Retin A (retinoic acid) when the literature itself only mentions an undisclosed concentration of retinol (a less effective precursor of retinoic acid). Anyway, great podcast, but keep your ears open and pay attention to misrepresentation of research! Sebastian Niemann Sebastian Niemann 5 months ago All episodes are for me one of the best podcasts ever made. Thanks for all the amazing work! 5 C V C V 5 months ago As a woman, I started looking into bioidenticals as a preventative measure once I went through menopause. My blood pressure had elevated, but the hormones brought it back down again. Supposedly one out of two women in post menopause have a heart attack. That’s a scary statistic. 2 Marlene DeLaTorre Marlene DeLaTorre 5 months ago Dr. Sinclair I am on my third Month of using One Skin and also just started using their new body lotion.. So far so good.. I know products like these take time.. White Daddy White Daddy 5 months ago Has David admitted to Botox? His occipitofrontalis and orbicularis oculi are totally paralyzed, causing a kind of sinister look. Not hating, but it would have been far more interesting to see his progress without dyed hair, fillers, and neuromuscular blockers. He is starting to get a bit of a Hollywood vibe rather than a naturally aging well 52 year old. 4 Larisa Inic Larisa Inic 5 months ago Thank you dr Sinclair on giving us your thoughts about HRT. It is always a pleasure to see extraordinary professionals who consider questions of their audience :) 7 katherandefy katherandefy 3 months ago David and Matthew are so generous with their time. Live long and prosper, guys. We’re listening and learning. Aman Yadav Aman Yadav 5 months ago My grand maa is 120 year old...she never used suns cream ..worked in the sun with the cattle..her secret is working and drinking lot of home brewed tea 2 Where Nerdy is Cool! Where Nerdy is Cool! 5 months ago Dr Sinclair, what's your view on adding collagen peptides to the diet? I've added a scoop to my mid-morning coffee and my pre-workout shake for a few months. I've noticed my nails grow quicker and my Charlie Brown bald head is actually sporting some minor hair growth. And my skin test is about 2 seconds (tent test your showed)... I'm also 52 KIYA Longevity KIYA Longevity 5 months ago Absolutely amazing podcast MEI mei MEI mei 5 months ago waiting for more episodes on this topic! 3 David Sinclair angellaonase angellaonase 4 months ago I get a few gray hair every summer and they darken when I get away from direct sun, year after year. The whole of the individual hair whitens in a week of sun exposure and two months after the root is dark again while the rest of the hair remains white. Majid Nabavi Majid Nabavi 1 month ago Hi Prof Sinclair, while I thank you for your great research and scientific work, I would like to draw your attention to one important aspect of your approach. By informing people about potential benefits of NMN and other molecules you are taking and not revealing the reliable brands, you are exposing people to numerous low grade or even dangerous products out there. This could potentially harm or seriously damage the health of innocent people who just want to be healthier. Why not reveal a couple or safe and reliable brands? King Bile King Bile 5 months ago Hello David Sir, I am 21 years old guy from India. I was suffering from insomnia for 1 year now. My doctor given me a prescribed antidepressant name dosulepin 75 mg. I wanted to know weather it reduce my life span or can cause some serious disease that can lead to death later in life Rose Rose 5 months ago I would just like to mention... I have been getting Botox since I was 25 (im 34). I suggest you take breaks from it and interchanging it with tretinoin instead of using them in conjunction because you can become immune to Botox (and this is a real thing look it up) it stops working in some people more than others. So little breaks and interchange with Morpheus laser or other options is advantageous. Rashad Aliyev Rashad Aliyev 5 months ago Thanks for the content. Lots of knowledge, but almost zero actionable information. This is a consistent trend on this podcast. Please consider sharing more actionable info. 3 T Kenz T Kenz 5 months ago as for hair loss and perhaps greying hair I have a theory that not washing them too often helps. also avoiding the BS shampoos. also avoiding hot water and hot air hair dryer 4 O O O O 5 months ago (edited) I appreciate this podcast. I tried Retin A and it gave me telogen effluvium. My hair started shedding like crazy and I even started to lose my eyelashes. I’be tested this twice and after about 3 months of trying it, the hair shedding started again. I’ve looked online and it seems I’m not the only one whom this happens to. Is there an alternative to retin a that u could use? Or do you know if the hair loss from retin a could be prevented somehow? 2 Ferdinand Goglia Ferdinand Goglia 2 weeks ago I've never exercised in 50 years, and I've probably eaten less than 1kg of veggies in 4 decades. Started feeling a bit rough recently, so I am trying to improve my health starting this week, so wish me luck😁 Natalie Axl Natalie Axl 5 months ago Thank you Dr, David 🙏 1 David Sinclair Dottie Calamaras Dottie Calamaras 5 months ago What should you look for and avoid in a sunscreen. Also what do you consider optimal D level? And should we supplement with D to get to optimal level and what helps in Vitamin D absorption. Mike Breen Mike Breen 5 months ago Thanks so much for this invaluable information. Would like to hear about photobiomodulation / near infrared sometime. Marta Marta 5 months ago I’m female, will be 59 in April…I’m not done watching the video yet, but I just did the skin test. Popped back down pretty fast, like 1 second. I’m happy with that. I also had my one and only baby one month shy of my 41st birthday. Natural, no IVF or anything at all. He’s off to college this fall. I’ve lived my life to be 105… glad I found you a few years back!! I am trying to do what fits in my budget, supplements and such. But I must say, besides having Familial hypercholesterolaemia, I think my genes are pretty good. 👍 3 Little Queen Little Queen 5 months ago I’m a 45 year old female and I fully plan on being a Centenarian. I’m gonna refuse to die and dammit, I plan on feeling and looking as good as possible the whole way 😌😌😌😆😆😆 2 Autistic Autumn Autistic Autumn 5 months ago Fascinating, the most interesting thing that I doubted was possible was the reversing greying hair amazing . ABLE International ABLE International 5 months ago (edited) As always packed with great info. Questions: 1. Are the topical cream such as Rogain and Retinol for men only or both? 2. About Hyaluronic Acid, is it effective to take it pill firms? 3. Couldn't find topical nicotinamide, but found nicotinic acid. The internet says nicotinic acid is niacin. Is it true? They do have topical nicotinamide? Which one is more effective? 4. Will it be helpful to take keratin pill for hair, nail and skin? Sorry for so many questions ektamarya ektamarya 5 months ago Can you please do an episode on eye aging, foods to eat, this is getting more important with everyone spending more time on screens and also with indoors and cold weather facing dry eyes. 2 Articulate99 Articulate99 2 months ago Always informative, thank you. chefchef9 chefchef9 5 months ago Regarding senescent cells, are they somehow related to general (superficial) skin problems such as acne or smaller, finer scars or other potential issues? And related to that, do you suggest activating autophagy via e.g. fasting could help with such issues? 3 Oat S. Oat S. 2 months ago I would love to hear more about Psoriasis as this disease can affect a large part of your skin. And there’s no cure for it yet, but would love to know how to make it better… stargazerbird stargazerbird 5 months ago So the things you can actually do right now are well known already - retin a, sunscreen, red light, controlled skin damage via needles or laser, Botox, minoxidil for hair growth plus HRT. Oh and the usual sleep, exercise, eat well, don’t stress. Maybe PRP? 2 yannick messaoud yannick messaoud 5 months ago (edited) started peptides a month ago, my hair that was thinning i am 49, started thinning at 25 but got worst at 41. My hair is getting thicker its amazing. Epitalon for 20 days 10mg per day CJC/IPA 300mcg before bed BPC157 TB500 to heal GHK cu 2mg per day for 1 month IGF1 LR3 1 month cycle 50mcg so many choices in peptides to revere aging build muscle mass and so much more. H H 5 months ago The science of UV damage to DNA really should be taught to schoolchildren. I know it would have saved me from many a sunburn as a teenager. I'd also love to see inside tracker expand to Australia! 1 PF V PF V 5 months ago (edited) My non-science way to looking younger: 1- wear colorful youthful clothes, 2- eat colorful food cooked plainly or raw if possible, 3- listen to good music, 4-engage in healthy sexual release, 5-give gratitude and pass it on and forward. I see Sinclair is wearing a youthful jeans shirt: youthful vibes right there! 1 duane french duane french 5 months ago Hey David, I wonder why you have never heard of Redox Biochemistry/ ASEA? It has done wonders for me. You talk about these molecules you take, but you never mention the name of them. 3 Ellen Collins Ellen Collins 5 months ago It makes makes me a little happy to inform you really, really smart guys that you are wrong about the largest organ in the body. The vascular endothelium is the largest organ in the body. The vessel wall is 5 times the size of the heart in mass and 6 times the size of a tennis court in area. The vessel wall is an active, integrated organ composed of three separate layers: intima, media and adventitia. 2 JuJu Herbst JuJu Herbst 5 months ago (edited) As a sole parent I often unintentionally fast, can't afford to buy meat and walk daily because I can't afford a gym. Great! The last thing I want to do is prolong the misery but I guess the stress and inevitable depression might counter all the unintentional things I do to turn back the clock. I'm 52, am 5 foot 7, weigh 54 kilos and apparently look ten years younger - the brutal irony! Dave B Dave B 5 months ago Is there a supplement that will slow the grey process? I know we are on the verge of a huge discovery but wanted to check if there is anything we should be taking now? Tatyana Nikolova Addict Boutique Tatyana Nikolova Addict Boutique 1 month ago This is the most helpful video i have ever seen...saved me a lot of wasted money on wrong things and procedures <3 Thank You Michael T Michael T 4 months ago This has been a fascinating program. During the pandemic, I began to think about my general health and covid related comorbidities. This has slowly evolved into an interest in aging. I found this video to be very enlightening and slowly moving me along a track of looking at the aging process. I look forward to learning more in a rational and scientific way. Well done guys. LOL ... but an additional decade of life by adopting a eunuch lifestyle really cracked me up. Sorry, not for me. Sonal S Sonal S 5 months ago I am glad that you mention women, quite important to note research where only men have been tested and how a particular drug or protocol may affect women. 4 Dr. Delaney on Dreams Dr. Delaney on Dreams 5 months ago Yes! good for including women. How about 70+ women? In dosages, in weight-based doses (starting at say, my 90 lbs.) and can you let us know if our Inner Age at Inside Tracker is a decade younger, how should that influence the supplements and doses we take? charisaob charisaob 2 weeks ago I am a believer at eating good portions of raw vegetables to get the vitamins and various beneficial ingredients that plant provides works like a charm as well for anti aging aside applying retinol externally. Example I took bamboo extract for a few months (and not even daily), and I measured my hair growth and I reached 1.6 cm per month. While the average is 1.25 cm. And I am 40 years old. Studies over the internet are mixed if silica from bamboo is absorbable and how much, but it worked for me. For my antiaging for my hormones, I take pueraria mirifica, but in small doses, and I will add some other herbs, but again small doses, not for breast enlargement, because it messes up my ratio with progesterone and I get delayed periods. But in small moderate doses rejuvenates me. I am a vegetarian since 31, and I do intermittent fasting mostly the 12 hour one for the last 5 years, now when I reached 40 I do the 16/8 one. I am quite happy with my skin and the way I look since financially I couldn't afford to buy expensive supplements for daily use, I will try some of the things Dr speak, like NMN now because I am more financially stable so I can afford them. But my personal diet is microgreens, the common vegetables from my garden with high levels of brix, lots of fruits nuts, lots of kale, chlorella, klamath lake sea weed, raw cacao, trans resveratrol, Ashwagandha, astaxanthin, bee pollen and pine pollen, bamboo, moringa, maca, all 3 colors, and various of oils for external use, like raspberry seed oil, avocado, etc there are so many, astragalus and various of other herbs. ALL in moderation, meaning some of them need to be taken only for 3 months at a time. Use wisely, but use them over the years use as many of herbs and vegetables and exercise keep a positive mind, a happy mind and I think we might be very close to a great antiaging recipe. I stop eating junk food, and I added like dozens of herbs and vegetables especially nuts and seeds. Now I am drinking almost every day a mix poppy seeds, bee pollen, linseed, pea protein or hemp protein, and it keeps me full and I am able to do my fasting much better than before. 1 A M F S A M F S 3 days ago Thanks a lot for sharing your knowledge with us simple people💝 Kristin Gibson Kristin Gibson 5 months ago LOVE the Spock joke! Great podcast, thank you. Sethflix Sethflix 5 months ago I'M REEEEEEAAALLLLYY enjoying your podcast@ Thank YOU! 1 JennyM JennyM 5 months ago I disagree that centenarians look younger. In the photos and videos I’ve seen the centenarians look pretty awful, with red eyes, thin mottled, discolored, saggy skin with dark lesions, causing them to look exactly like what they are: 100 year old people! I’m glad they are biologically healthy, but they do not look younger. The only clear cut effective way to prevent these super discouraging results of a long, healthy life seem to be medical interventions including dermatological and surgical interventions. It seems that such interventions also provide a mental health boost which is “ nothin’ to sneeze about.” (PS: my grandmother in law lived to be 105 and remained healthy until the last 9 months. She also had breast cancer at 95–non invasive— and lived another 10 years. She birthed 11 children, was a hard worker, and loved to fish.) 4 musicalfringe musicalfringe 2 months ago The trouble with tacrolimus is that it seems to be cardiotoxic in chronic use. My father, a liver-transplant patient, was on it for 5 years before switching to a different immunosuppression regimen (both very low doses), and now suffers from atrial fibrillation. It seems that about 5 years is the point where cardiotoxicity starts manifesting. Bret Weinstein's "all our lab mice are broken" hypothesis predicts a silent epidemic of cardiotoxicity in our drugs, and I'd imagine this is something to take into account with all these rejuvenating drugs. B VB B VB 5 months ago Suggestion for a topic: Any chance of a video on what to measure and tests that people may want to have from time to time and how to know whether these are legit and/or will actually tell you what you are hoping to know. E.g. would a whole body MRI every couple of years detect tiny tumours or not cos of X, Y, Z? I do hope you make a video on that. Thank you for sharing with the world so much already, though. 1 LATSRN LATSRN 3 months ago David I’ve read that Pregnenolone is a precursor of DHEA is there a place for these two supplements to work synergistically? Can they help with all the little aches & pains of ageing (I don’t use nsaids as I think they cause too many liver problems) Love your talks & lectures here on YouTube 👏👍 C A C A 5 months ago I'm glad they talk about menopause! So many women are going through this and all it's bad vicious side effect. J B J B 5 months ago Cheered me up. I'm 74, did the skin pinch test and it went down right away! Julia Julia 5 months ago Excellent information! Thank you for this podcast! 3 La Vita La Vita 5 months ago I have enjoyed as always ! Thank you ~ 1 David Sinclair Paul Kiesow Paul Kiesow 1 month ago Greetings, Dr. Sinclair. I was recently featured on DoNotAge's Twitter feed as a septuagenarian outlier [as it were] on the aging continuum. I've faithfully ingested 1 gram/day metformin for two decades, likely strongly contributing to my experience of aging. Having added 1+ grams/day NMN for seven months, my nails are clear of ridging/yellowing/thickening; this had not fully been the case with metformin alone. A most noticeable change is the complete absence of aging evidence in toenails. Your comments on skin 'snap back' were interesting to me: about two seconds now with NMN and adding collagen peptides and hyaluronic acid. If you have an interest, I will enjoy discussing with you these issues, including the SIRT6 activator I began two months ago. —Paul Kiesow Sella Ghazouly Sella Ghazouly 5 months ago Can you add Arabic translation please I love your videos so much but sometimes I can't understand little of words thank you for all things ❤️❤️❤️ Margaret Attiyeh Margaret Attiyeh 5 months ago Appreciate the comments on HRT and menopause this episode as the topic was glaringly absent from the last. 1 snow white snow white 5 months ago So sad that I can’t get athletic greens in Africa. Thank you for this episode guys. Pottenger's Human Pottenger's Human 5 months ago Niacinamide cosmetics also probably helpful, don't think that was mentioned. You can get niacinimide very cheaply in bulk and add it to an oil too. 3 Daniel Fradkin Daniel Fradkin 3 months ago Hello,thank for the great video.I noticed that very popular supplement for skin is biotin but you didn't mention it in your lecture.Can you comment on it?Thanks a lot Jake Jake 5 months ago PRF is now being proved that it is more powerful in stem cell reproduction then PRP which is more intensive and costly to for the patient in Drs office. Is it possible Dr Sinclair to research more of this for your future podcast coming up on this subject. I’m also a member of “Dr David Sinclairs fans” on FB. Monique Cobb Monique Cobb 5 months ago I’m 49! No one ever believes me & took this photo 6 mos ago w no filter. I use The Body Shop Vitamin C moisturizer day and night. I also use $9.00 Collagen cream from Walmart. Works wonders!!! Good luck.💋 2 eliana eliana 5 months ago (edited) What about put tretinoin (topical retinoids) all over your body to reverse the sun damage and to prevent skin aging? also could be helpful to take oral retinoids (isotretinoin) at a lower dosage to do it better? (for this second option there is a brazilian study) isabel camera isabel camera 5 months ago When you mention female researches could you please give their surnames? It's difficult to Google about them just by their 1st names. Other that that, Looove your cast. Depply appreciated Kinan Isam Kinan Isam 5 months ago This broadcast could use Dr. David Sinclair presenting on his own, “Huberman Lap” style. He is being interrupted way too often, unfortunately. 3 PlantBased AthleteRealtor PlantBased AthleteRealtor 1 month ago I am grateful for all your podcasts 💫🙏🏻 E. Sald E. Sald 4 months ago I'm not doing any special or intentional care to keep myself young, and even like that, when I do the skin pinch test on the back of my hand, my skin returns back in place in two seconds, and I'm almost 56 years young. Dolly Vandenbrink Dolly Vandenbrink 5 months ago Wish I knew All this Info when I was young, Thanks dr David Sinclair. Richelle Marleau Richelle Marleau 5 months ago I have a question: I've had beautiful long, hard nails my whole life, and then my father passed. It's been 2 yrs, and my nails have not grown since. I've tried biotien, iron, silica, and nothing works. Thoughts? Direction? Jessica Bender Jessica Bender 2 months ago Dr. Sinclair: I have bad reversal of my grays, now to blonde and brown again. This occurred when I upgraded my lifestyle and with each pregnancy. Please explain how. a_person a_person 5 months ago Did someone managed to formulize a PRACTICAL takeaway? I.e. what options of available treatments for what types of anti aging? 3 Paul Mr Paul Mr 5 months ago What about Reishi mushroom for preventing/reversing gray hair? Its a known Inhibitor of DHT. Might want to check that out 2 Fion Mor Fion Mor 2 months ago I'm wondering if DMSO could push the HA into the skin for a better result instead of injecting?... for those who don't know.....DMSO is Dimethyl sulfoxide is an organosulfur compound with the formula₂SO. This colorless liquid is an important polar aprotic solvent that dissolves both polar and nonpolar compounds and is miscible in a wide range of organic solvents as well as water. It has a relatively high boiling point. 1 Nicole Matthews Nicole Matthews 5 months ago What physician is the best one to see in order to have these tests done to check hormones? My MD and even my gynecologist did basic tests and didn't seem concerned, but it is clear that there have been major changes hormonally. Lani R. Habrock Lani R. Habrock 4 months ago Can you do an episode where Dr. David tells us his skin care routine bc he looks so young and he said he doesn't do Botox and he hasn't done microneedling! Xenia Stefanescu Xenia Stefanescu 5 months ago David, I am 74 and do not have grey hair.,and generally , I do not look my age., and I am not on any medication. Also . I wanted to say that I had so much stress in my life, maybe as much as the stress of 5 people, over their whole lifetime.Also I should mention that I did never smoked, or drank alcohol, or took drugs.,maybe that helped. 1 Pit Bull Pit Bull 5 months ago I believe, because of the chronic over consumption of Omega 6 fatty acids, PUFA, our cell membranes become dysfunctional and the metabolites of Omega 6 fatty acids cause health issues. 3 Park SuMin Park SuMin 5 months ago Thanks again Dr. Sinclair! What do you think about pregnant woman who are taking NMN or other molecule such as resveratrol, fesetine, quercetine.. 1 Aylien Aylien 5 months ago "you're as old as you look" is so interesting to me. When I'm without makeup people think I'm 15 and I'm 26, soon 27. I've used sunflower seed oil for many years and I always wear SPF even though I live in a dark & cold climate. 1 Marilyn Marsh Marilyn Marsh 2 months ago I am taking a capsule recommended by my optician, and my hair colour is starting to return to what it was. missmerbella missmerbella 5 months ago Dr. Sinclair, I've read Retin-A actually thins the stratum corneum. This isn't a concern because overall it still increases collagen and skin thickness? 1 John brooke John brooke 4 months ago God bless you Dr Omole on Youtube you are really a true definition of a great man thanks for helping me get rid of genital herpes.. Marcia Millard Marcia Millard 5 months ago (edited) I am 62 and my skin snapped back went down in less that a second! 👏🥳 5 Miki Vasic Miki Vasic 5 months ago Soooo, what's the verdict on micro needling? Is it effective at anti-aging for the skin? Jarred Lozano Jarred Lozano 4 months ago Couple spoons of yogurt, half a cup protein and BCAAs, half coconut and filtered water and NMN resveratrol = Uber health. The BCAAs are already crazy for exercise, just kills soreness immediately, the flavor combos pretty good too. I tried without the yogurt and the resv. stuck to the sides, even with olive oil in the protein the resv. stuck to the side. Susan T Susan T 1 month ago no need to apologize for speaking on a subject for which you do not share the body part. An orthopedic surgeon does not have to break his/her own bones to know how to fix someone else's broken bones .... you guys are doing great - much appreciation. Clint Dodson Clint Dodson 5 months ago (edited) A huge fan of your work...Thank you!!! One quick question, does using MCT oil to mix with resveratrol make sense? Ciarog Ciarog 5 months ago Hi, I was wondering...if the skin is all one organ, why doesnt using retin A on your face improve the skin on your legs? Dr. Sammy Pryor Dr. Sammy Pryor 5 months ago (edited) As a naturopathic doctor, I want everyone watching this to know that menopause is not a disease. If you are in menopause early because you had to have your ovaries removed, then yes you need Bio-identical hormone replacement therapy (BRT) not HRT. If you have a lot of symptoms from menopause then please come to a naturopathic doctor because HRT has been linked to many cancers and your risk of strokes and other CVD events. 4 wayne warren wayne warren 5 months ago 55:46 you say that laser treatment has "been approved by the FDA", can you clarify whether it has been approved as safe vs approved as effective for hair loss? My understanding was that it's only been approved as generally safe, not necessarily effective for treating hair loss. 2 sheri sheri 5 months ago Amazing work! Orion Rodriguez Orion Rodriguez 5 months ago 1:09:20 "if you can keep yourself looking good by doing the right things you'll probably end up living longer too" That makes sense, so many centenarians (people who are 100+) used to be hot Gloria Gloria 5 months ago THE 2 OF U TOGETHER R WONDERFUL FOR ME 2 UNDERSTAND I WISH THIS WOULD GO LONGER THAN 8 PODCASTS Stand Up Eight Stand Up Eight 5 months ago I liked how Mathew switched from ‘poopoo’ to ‘denigrate’ without missing a beat 😂 1 Pottenger's Human Pottenger's Human 5 months ago I do lots of red light/near infrared. Great for skin and also joints and wounds. 3 Enqumesk Mekonnen Enqumesk Mekonnen 4 months ago Great information. But for those of us who don't prefer to use lab made products, if you have naturally occurring alternatives you can suggest to us that would be highly appreciated. Like for example i heard rosemary oil is as good as minoxidil. Christina Smith Christina Smith 5 months ago I think you will find how spending time on women's issues can really help your following. ;) My endocrinologist recently told me that I either go through menopause or I am dead; that is life. Ok. But I want to avoid the symptoms/suffering my mother experienced for over a decade! HRT triggered a thrombosis and she nearly died...so I want to proceed with caution. It seems I appear younger than my age and as such get little sympathy from my gyno who has passed menopause and this older man endo. Apart from other hormonal and PMS issues, my testosterone and DHEA measures high, so I fear male pattern hair loss as my estrogen lowers -so loved this podcast. I wish I could find a medical team who didn't treat me like a hypochondriac and/or resent me for wanted to optimise my health!!! Mustavo Gaia Mustavo Gaia 5 months ago I've once consulted Dr. Sinclair: "Doctor, do you have something that would make me more handsome?" He asnwered: "Do you know that what I do is science and not magic, right?" ャン・ティオカ ャン・ティオカ 5 months ago hands down my favourit channel now =) I just really like you guys. Abs Online Abs Online 5 months ago If you look after your health you don't need replacement therapy. Also its never too late to look after your health. 1 rebaked rebaked 5 months ago Live long and prosper 5 Jeffrey McKenzie Jeffrey McKenzie 5 months ago Could listen to these guys all day 1 Roman B Roman B 5 months ago “Not like today, you just let kids blow in a wind” 😅 I dont know about US, but in Czech we still have to put solid effort to raise a kid 😂 Tony Ing Tony Ing 5 months ago Thank you for the information. Is it true that Retinol and Retinoic acid are deactivated by any form of light and therefore be applied at night when you are ready to go to bed? Scarlet Letter Scarlet Letter 5 months ago "Drug mimics fasting," rejuvenating the skin. Maybe intermittent fasting is a cheap healthy natural alternative. Conversely, perhaps snacking all day is metabolically aging? 1 Michele M Michele M 5 months ago Avoiding too much saturated fat can also slow hair loss, because too much saturated fat reduces blood flow. Barbara Lanzante Barbara Lanzante 5 months ago David Sinclair please can you please if you don’t have the answer but I’m very curious on bio identical hormone therapy 3 David A David A 3 months ago Thank you for sharing your hard earned wealth of knowledge. Thank you. Mahnaz Alsharif Mahnaz Alsharif 1 month ago This is a question for David sinclar: there is evidence that fasting particularly 3-7 days is associated with osteoporosis. How can then fasting be justified particularly with postmenopausal women? Maria Maria 1 month ago From the paper of Mariana Boroni: "Rapamycin caused a detrimental effect in overall skin structure, including a a thinner and more disorganized epidermis" Christina DuBois Christina DuBois 5 months ago Excellent podcast series question please do you see any value in red light therapy Milk Andhoney Milk Andhoney 1 month ago I’m 55 and had a complete hysterectomy. I was denied HRT due to my mother having breast cancer. So now I’m suffering. Hair loss, libido loss, hot flashes and slower metabolism and I’m an athlete trying my best with zero hormones! What can someone like me do when no doctor will help? MrGriff305 MrGriff305 5 months ago (edited) This is a profitable thing to discuss and write books about. I'll bet there's even venture capitalist money to take. He's a clever little quack. 3 Teddy Li Teddy Li 5 months ago Thank you to athletic greens for sponsoring this Lord James C Beeson Lord James C Beeson 2 months ago Your amazing, I spent hours listening to you on other podcasts and wondered if you had one, and you do! I took notes! I never take notes. lolol Lea DiMento O'Brien Lea DiMento O'Brien 5 months ago doesn't the GFR value contribute to the aging process. Im a blood donor and read that after donating your GFR can go down to 55 or so. It did. then after I panicked, after I read that info I got it up to 61. it may have been dehydration after donating that I did not drink enough. stephen lucier stephen lucier 5 months ago Fantastic as always boys! Blueberrymint Blueberrymint 2 months ago so my irritatingly fast growing nails are actually a good sign... it's something to meditate about when i have to clip them again. is it the same with hair growth? the reason i keep my hair long is that i don't have to cut it in shape that often. itgrows about 20 to 25 cm a year depending how sick i was and how much stress i had. could be more, but i doubt it is less. 2 years ago i had cut it short and didn't cut it for a year and it measured up to 25 cm more, while in a stressfull year (i had my first white hairs starting to grow that year, a good few years earlier then my mom had them :-/ i was barely 36. it was a very stressful couple of years leading up to that. stress reduction and stress management has become my top priority as it had so much adverse effects inside and out. i also got my first wrinkles last year, allthough they are starting to fade again now that i'm feeling better and more relaxed for more then half a year and eating healthier again. stress is the most difficult to get a grip on, when life gives you a whole lot of lemons, but it's so important to learn to deal with it, as good health is needed to cope with stress in a helpful way, while stress eats away at your health. it's something best coped with in advance. never ignore early signs of stress ;) (i had a burn out, due to ignorance of those signs and thinking i could cope without help as i still felt healthy and strong, untill the balance tipped) Eugen Muzica Eugen Muzica 5 months ago So tretinoin (retin A) is bad for you or its still good to use once in 2-3 days ? Age 25 4 Art Art 5 months ago Hi, how does berberine compared to metformin? Are there any downsides to Berberine according to science? Luc Chase Luc Chase 3 months ago I think achieving rejuvenation of appearance, without faking it, demonstrates mastery of anti-aging. e.g. reversing greying of hair (without dyes and such). C Fitzhugh C Fitzhugh 5 months ago Correct! I’ve seen Paper Skin Tears! 1980s. Decubitus, amputations, This is a great episode! Annette Sichamba Annette Sichamba 2 months ago Thank you for your knowledge shared. GamezGoneWild GamezGoneWild 5 months ago Why do I keep saying "Oh david" whenever I watch these amazing podcasts Sean Sean 5 months ago I hope Australian free sunscreen is coral reef safe because that stuff definitely bleaches them even at low concentrations 3 BJ Speck BJ Speck 13 days ago (edited) I'm 71. Is it too late to use the combination of estrogen and progesterone? If the hap cell affects bone and muscle can it be used to fix arthritis? I have a very bad shoulder and my upper back/neck. I have used stem-cells to fix my left shoulder which worked pretty well, not so much with my right shoulder, haven't tried it on my spine. Insurance companies don't cover this. Lea DiMento O'Brien Lea DiMento O'Brien 5 months ago I think the butane in grass-fed, grass-finished organic butter is good for preventing aging guitarrista666 guitarrista666 5 months ago (edited) OK, this is audacious of me, but I think they are making a massive blunder on the skin test. I'm nearly 80. So, when I take the skin test on the back of my hand, yes, a very poor recovery rate, but when I do it on a part of my body that is usually shielded from harsh chemicals and the sun, like my lower abdomen, then the recovery is like a teenager's. So, all the hand test does is show what harsh chemicals and the sun will do. 1 MPM Revolution MPM Revolution 5 months ago Great podcast and inspiring,maybe someday we drink pill and we can rejuvenate in a year or so Just A Woman Aging Just A Woman Aging 5 months ago So I promote you on my podcast my YouTube channel and my TickTock channel. I have 27,000 followers on my TikTok and one asked me a question today when I posted what you said about growing hair with monoxidal and Tretinoin. The question one person asked was if you stop using the tretinoin and the minoxidil does your hair fall out? Thank you 😊 Lea DiMento O'Brien Lea DiMento O'Brien 5 months ago Bone broth? Kefir? Fermented foods? 4 Shorts_luv Shorts_luv 9 days ago Thank you for your valuable insights to atheism aging process George H George H 5 months ago I’ve emailed pictures to David at his Harvard lab of the re-birth of hair on my formerly mostly-bald head - and it’s dark, not gray hair. This rather amazing phenomenon occurred within two months of taking the same supplements as David, and has only become more evident over time. At age 75 (Epigenetic age via Horvath clock is 60), having my hair back is a great thrill! I’m surprised you didn’t discuss this sort of thing since the color-changing and re-growth was observed in the Stanford thymus regeneration trial using growth hormone, DHEA and Metformin. Keep up the great work!! Hector A. Vasquez Hector A. Vasquez 5 months ago Great info! Ty! David Sinclair Tonya M Tonya M 2 months ago I’m a 49 yr old half Hispanic, half white decent, I tan easily and get pale easily. I live in Hawaii. I’m menopausal and have hyperpigmentation. I’m wondering what is the healthiest, non toxic, natural sunscreen? Like super natural and can I make one? maria Batlles maria Batlles 2 months ago I'm almost 63. The skin on my hand sprung straight back. :) brooke jaeger brooke jaeger 5 months ago Loving the podcast! I am 51 and my skin snapped back immediately ! 4 Frank Fibonacci Frank Fibonacci 4 months ago Thanks for the great info. What do you think about facial exercises to preserve youthful appearance? Lifespan Wellness & Beauty - 60 is the New 40! Lifespan Wellness & Beauty - 60 is the New 40! 4 months ago I'm 61 and my skin pops back down immediately. 👍It's all about how you care for yourself. kapa0224 kapa0224 9 days ago DR. Sinclair, is there hope that in the future, it will be possible to grow cartilage in a hip and avoid joint replacement? Are you currently doing any clinical trials now to particioate in? Thank you! Monty Palmer Monty Palmer 5 months ago Skin peels can remove the upper most damaged layer with regrowth coming from less damaged cells. 1 1LaOriental 1LaOriental 5 months ago I’m 63 and the skin turgor test for me is 1 second. Funtimes Funtimes 5 months ago How many people pinched their skin? Thumbs up if you did 3 L'EdAM L'EdAM 3 weeks ago Menopause starts in mid to late 40s and 50s. There are women all over in non-western countries who are having healthy children in their 40s and 50s. A woman experiencing menopause in her 30s is a medical anomaly (through no fault of her own, though.) Carol Orentlicher Carol Orentlicher 5 months ago Dr Sinclair please talk about whether it is safe or not to replace estrogen and progesterone post menopause using cream, and if that should stop at any certain age due to risk of Breast or gyn cancers. Jenxs J Jenxs J 5 months ago Darling, good diet, exercise, sun-blocking, retinol, Botox and fillers. I look at least 15 years younger. 2 Kate Alvo Kate Alvo 5 months ago Hi! I just went to Inside Tracker, and the discount they offer is 20%, whereas Dr. Sinclair says it’s 25% when mentions the sponsors at the beginning of the podcast. Just FYI so maybe you can fix that :) 1 ILHAM ALHASSAN ILHAM ALHASSAN 5 months ago Thank you Dr David Sinclair Pete Dawson Pete Dawson 5 months ago Future vampire checking in 8 B Bryan B Bryan 5 months ago Because of your podcast and ytube i am now aware that aging is a disease that can be treated. Victor Abadia Victor Abadia 5 months ago Levels not available in Puerto Rico ! My Identical twin brother lives in the south west and I live in Puerto Rico we were hoping to compare data. Still love the work you guys are doing. gold gold gold gold 5 months ago Pls make video on functional medicines... Any also ways to improve eye health 1 Ponte Vedra Ponte Vedra 5 months ago aaaahhh Doc, you are so sweetly great in your advertisements..... I trust you with my life, as you have led me, inspired me, through so many hurdles in my life. 1 Brian Starr Brian Starr 5 months ago (edited) Enjoy having a cup of coffee and listening every Wednesday at 8 AM. 1 João Medeiros João Medeiros 5 months ago Hey David. I am a very big fan of your content and I want to listen and trust your advice, but I have to say that I don’t particularly enjoy what you are doing in straight up copying basically everything from the HubermanLab podcast . As a pioneer in many different areas of the modern health, especially the anti-ageing field, I expect you to develop your own style and not follow what others do. I mean, wasn’t that your whole way to approach life and science? Do not take the shortcuts, if you really believe that you have the best content, people will come, sponsors will follow, and most importantly of all, you will feel like you really created something great that belongs to you. 3 Eugenio Cuppone Eugenio Cuppone 5 months ago Hi professor! I steal some space here, for sure not the best place, and maybe some of your attention (I suppose I can do that hardly, but I try!). Great work, great science and great targets... thank you for all! I just I wish to speak about TCP/IP model (here or anywhere)... maybe it's not a good example for modeling information that travel through time. I really love Claude Shannon (specially the Nyquist–Shannon sampling theorem) and TCP protocol and IP protocol too. TCP is the solution to be reliable, IP is just a best effort protocol, and there is no observer in both... maybe we can abstract it, but I don't think it's a useful mental effort to do that. By the way in TCP there are checksums, aknowledgements (impossible to send them through time, for now) and connection (IP is connectionless), but no observers: hopefully! :-D I have said my opinion, maybe I feel better now. Again a big thank you for your hard and interesting work! Machie the Apachie Machie the Apachie 5 months ago (edited) You guys really need to address dry fasting as opposed to wet. Waaaay overdue. Great stuff btw 1 Lauren Sargent Lauren Sargent 5 months ago So what should someone like me who had PCOS, kids at 40 & 44 (#2 at home with a midwife and no meds), didn’t go through menopause until 55 do now 10 years on? Is HRT a good idea at this point? 1 Hamir Mahal Hamir Mahal 2 months ago To clarify, at 52:32, the quantity 9.8 to 15.8 nanomoles per liter is the optimal level for testosterone, and not dihydrotestosterone (DHT), correct? The study linked in the description says, "Testosterone (T) levels decline with age and lower T has been associated with increased mortality in aging men. However, the associations of its metabolites, dihydrotestosterone (DHT) and estradiol (E2), with mortality are poorly defined." The only reference to "9.8 to 15.8" on the page says, "Instead, an optimal range of circulating total T corresponding to a range of 9.8 to 15.8 nmol/L (282–455 ng/dL) exists for older men, which predicts survival independent of other risk factors." Peter Schmid Peter Schmid 5 months ago What brand of hair dye does David Sinclair use? 2 Spen Gali Spen Gali 5 months ago Women, today, are not going through menopause, at 40. They are having babies in their 40’s. Need to update your science! 6 Tammy Bott Tammy Bott 5 months ago I was taking bio identical hormones for 9 months. I had to stop when I was diagnosed with breast cancer. My surgeon attributed my cancer to the hormones. I wonder. Nonetheless, they remain off limits for me. 1 kimberlee kimberlee 5 months ago Is the low light laser therapy that you mentioned the same thing as red light and near infrared light (photo bio modulation) that I’ve sunk $700 into? (I bought a red light/NIR panel.) Thanks! BadMannerKorea BadMannerKorea 5 months ago (edited) I get Botox and I’m planning on getting broadband light treatment. 2 resistapathy resistapathy 3 months ago I think that anyone who purports to know how to help people look younger must divulge any procedures they have had, like injections, skin peels, etc. Jo Shannon Jo Shannon 2 months ago I'm 80. The skin test took me 5 seconds! Suzette Mills Suzette Mills 5 months ago Poor people think about what they can buy with their money, Rich people think about what they can invest in with their money 💰💰💰; 44 Cody Young Cody Young 5 months ago In terms of minoxidil which is talked about it around the 55 minute mark... hasn't it been proven that it can significantly age the skin and cause wrinkles? Even dark circles? 1 ILKE GUERCAN ILKE GUERCAN 5 months ago great topic and episode thanks Dr Sinclair but i thought you’d address lasers and PRP ? also did I understand you correctly that senolytics are effective on skin rejuvenation when used topically ?? really? It’s a Shrimp It’s a Shrimp 5 months ago 2022, life changing information wrapped up in a Canadian tuxedo. 🙂 1 Sevi Yoga Sevi Yoga 5 months ago Subscribed!! I appreciate your work and your looks!!! Kerry Jean Kerry Jean 5 months ago I believe hair greying can be reversed by eating cooked mushrooms x 1 Cat Day Cat Day 5 months ago So instead of just giving us information and advice, we have to listen to a long justification of why an issue that primarily affects women is important. The sexism of the host who states how he needed to be convinced to have any interest in the subject is evident, not least because female hormones were considered an aside and a spill over from the last episode. I don't know about anyone else but I'm really getting sick of macho dude bros monopolizing self improvement/care to women's detriment and not including us with parity. 8 Douglas Abramski Douglas Abramski 5 months ago Maybe hair growth in different areas (inside the nose for example) have a purpose like extra filtration of external debris or particulates? 1 GreenTara2010 GreenTara2010 5 months ago (edited) Broad band light facials aka photofacials are approved by the FDA for antiaging. That and the microneedling are the best antiaging procedures. Perhaps some anti-aging skin creams work too. Little Voice Little Voice 5 months ago What are your thoughts on light therapy for skin aging? 1 Paul Sansonetti Paul Sansonetti 5 months ago avoiding PUFAs ( approximately 33% of the American diet per Dr Michael Eades) though extremely hard, is absolutely essential for skin health, lipofuscin and liver spots ate basically PUFAs + iron high amounts of coconut oil baths in borax pregnenolone can have a " facelift" effect high dose niacin works great to get blood to the dermis due to its vasodilating effects Indie Gold Indie Gold 4 months ago Here is why everyone should listen to D Sinclair...glowing white teeth, looking 30 at 50+, bone structure. BOOYAH! Carolyn Aguilar Carolyn Aguilar 5 months ago Another awesome video! ❤️❤️ Am investing my time and money in crypto now, this new price is a clear sign for new investors to come in ✅✅... 14 Ola Aldous Ola Aldous 5 months ago So glad you talked about estrogen and menopause!!!! Thank you!!! 1 William de Ora (de Silva) William de Ora (de Silva) 5 months ago Thanks guys, super podcast. Kenya your esthetician Kenya your esthetician 5 months ago So, gents, it’s more than we have a life, and then we’re in menopause. It’s a lifelong process leading to that first year of no period (which is the definition of menopause). I appreciate you including over half the population in the discourse. Please keep it going and invite some guests on with the experience and expertise. Cheers! 1 octaviano1296 octaviano1296 5 months ago (edited) David Sinclair looks at least 8 years younger than his chronological age. mae quin mae quin 3 weeks ago I’ve heard that adhd medications age you, is there any way to combat this? Shayna's Miami Home and Health. Shayna's Miami Home and Health. 5 months ago Fascinating and wonderful content… Angelina Shaw Angelina Shaw 4 months ago Hi, pls have more podcasts, do you have a skincare line yet, if so please let me know, tks, I love all your info 1 Laura Makin Laura Makin 5 months ago Thank you for this lads : ) Falcon one Falcon one 5 months ago (edited) What about phytoceramide supplements made from rice and sweet potatoes? Will that be beneficial? Also would Amla extract supplements help with reversing grey hair? 1 Maria Shumyatsky Maria Shumyatsky 5 months ago I had my skin destroyed by a couple of really aggressive cosmetic procedures. Is there a way to reverse that. I had really healthy and young skin and then turned old within minutes. It is systemic damage, on cellular level, hair also. Would you advise? Yvonne Novak Matz Yvonne Novak Matz 5 months ago Very surprised by the nonchalance with which you discuss immunosuppressive drugs. These are medications with a multitude of side effects, closely monitored in the clinical setting and dosed carefully. These drugs also generate the need for therapy pre-screening and vigilant surveillance for cancers, due to immunosuppressive action. You are a professor of genetics—not a pharmacist, physician, health clinician, or oncologist. I am confused by the expert stance you take beyond your personal scope. 2 cearilin dubhlaoi cearilin dubhlaoi 5 months ago This is so helpful as a now 52yr old menupausol woman you have no idea how fast I've aged since turning 50..I'm on bio identical HRT nearly 2yrs now but it has not helped my skin my hair or nails..in fact all 3 have deteriorated bady especially my hair I've lost 50% of its volume..I used to have great thick fast growing hair ..my skin is now just sagging its totally depressing 😪..I was always a good looking woman always got attention up to been 50yrs old..I feel old and now HRT doesn't do anything to improve your skin or hair..that is my experience & my older sister... Hassan Syed Hassan Syed 5 months ago Not only nails but hair growth is a good indication of health and aging slow Heather D Heather D 3 months ago Have you studied the science behind DefenAge’s defensins? I have my own theory on retin-A. I’m not a fan of daily or every other day, retinols. I think retinols cause inflammation and inflammation is not something good long term. I think it’s better to rotate, use for 3 months and then three months off (use peptides, AHA, or soy type products depending on the person). What do you think about that? Jennifer McCullough Jennifer McCullough 5 months ago I wish you could reverse osteoarthritis my fingers have changed the bone has relined itself 2 Asiaisreal Asiaisreal 5 months ago I wish I knew that Retinol was Vitamin A I used a retinol product after using Vitamin A and my skin dried out so bad I had to shave my face, steam it and drench it in Coco butter and Castor oil. Irene Reyes Vlogs Irene Reyes Vlogs 1 month ago amazing, dr sinclair looks very young, I never thought his on his 50s, i thought we have the same age😂30s M M M M 5 months ago Love the topic! Appearance DOES matter! 2 Jeannie Nelson Jeannie Nelson 5 months ago I stopped using Retin A and switched to acid peels. My complexion is much more taut , smooth and bright with no discoloration. Should I go back to Retin A??? Hope Carlson Hope Carlson 5 months ago Clicked so fast! Thanks again for the great info! 1 Brandon McWalters Brandon McWalters 5 months ago lovely podcast ;) M M M M 5 months ago "And if it doesn't work it'll just feel longer" LOL 2 Chuck Lohn Chuck Lohn 4 weeks ago I wish you guys would have discussed some of the Liposomal NAD+ skin creams some more. I would like to hear your opinion on it. I am trying some of the skin care products from "Renue by Science." Thief Face and Body Serums. Nilima Mittal Nilima Mittal 5 months ago with respect to serum alpha melanocyte stimulating hormones: how can these be increased? what is considered too low for libido, hair color, appetite suppression, etc... 1 Janet Bederman Janet Bederman 5 months ago When you are healthy, you look good. They go together 1 Rex 117 Rex 117 5 months ago Do you happen to have any info on how to get rid of acne or what it means to have it? glatze fratz glatze fratz 5 months ago Oral minox (loniten) works for hair growth - but maybe not the best idea for improving the skin..? 1 GeoTex GeoTex 5 months ago In an interview I saw recently with nutritionist Trudy Scott, she said ingesting collagen can lower serotonin levels. True? Jessica deBen Jessica deBen 4 months ago (edited) Can you include lasers and Broad Band Light medical spa treatments? I just had this treatment done and WOW. I follow Dr Patrick Bitters work and the Stanford University clinical studies show evidence that BroadBand Light Treatment Promotes Youthful Skin on a Molecular Level! Koko Love Koko Love 5 months ago I hope you read this message. How do you get rid of excessive moles all over my neck and stomach.. started to come in my 30's. My mom doesn't have them 😕. nasmeana nasmeana 4 months ago I am using issotretionoin, 15 months already, also fast at least 16-18 hours and often do OMAD and use retinol 1 to 2 times a week. is this contraproductive? ___ ___ 5 months ago "Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men" any comment on this study? 2 V G V G 5 months ago Hi ! Does anyone knows how many hours of fast can start Chaperone Mediated autophagy (CMA) ? How is it different from Micro & Macro autophagy (in a layman's terms plz) ? Gains & benefits of CMA over other autophagy ? Angie Damian Angie Damian 5 months ago We’re talking about getting molecules from the outside into our bodies to reduce the rate of ageing. That’s cool enough but doesn’t that negates the fact that our bodies only needed food and exercise for so long to stay alive and now we’re looking at outside manipulation to instruct our cells to continue staying alive? What ever happened to our cells that we now depend and rely on human intervention when it has thrived for so long without it in the earlier stages of life on earth? Something seems wrong here. I maybe wrong but we’re overlooking something in our biology and humanness that makes us focus only on the seen stuff and ignoring the unseen ones. Thank you for your great content. More power! Info Ra Info Ra 5 months ago What to check regarding liver health ? Especially if always tired nat a'la nat a'la 5 months ago Dr Sinclair, when you talked about RetinA, you said the cream 0.5%, is it correct ? or 0.05 ? thank you ! L.P Moonstone L.P Moonstone 5 months ago A few months ago, I bought a bottle of wine. The cashier asked for my identification. I said to him '" whaaat?! Are u serious , you want to see my I.D? How old do I look?" He said I look very young. wow, I must be doing something right. I am 40 yrs old Domerilo Domerilo 1 month ago Switched to the carnivore diet and all my skin problems went away. It is now thicker, hydrated and I don't ever use sunscreen. Most sunscreens are toxic. Samuel Hajdúk Samuel Hajdúk 5 months ago Skin is only skin deep. The real driver of cosmetic aging at least in the face is Bone loss. What about aging of the bones? I read some studies that report that nad+ boosters and senolytic drys can revert at least some of age related bone loss. 2 Katha Rina Katha Rina 5 months ago I'm 38 and Look young (like 30) but I don't have children yet! Aging is so scary. I want a child but also a good husband and father. It's not fair that woman's eggs and ovaries age earlier. I wanna lear more about reverse aging your female parts. I hate intermittent fasting🙈 but will do the rest... leftyla leftyla 2 months ago Fantastic discussion. Subscribed. Dee La Dee La 5 months ago Dr. Sinclair looks very young, but for his podcast he should make sure the colors around him and on him match his cool undertones. He would look even younger and healthier. He might consider consulting with Jennifer Butler, I believe she in in California or another professionally trained Color Therapist. Kas Tarzan Kas Tarzan 5 months ago hey dave, can you guys talk about the direction of cosmetic medicine is goin, where ppl can alter there appearance. For example increasing adult height, muscle enhancements etc. Iv read a company in south korea has patent on increasing adult heights. Thanks Katherine Moreland Katherine Moreland 5 months ago An excellent episode. Delia Ocampo Delia Ocampo 5 months ago Looking younger in the genes too the wrinkling of the skin even the greying of hair blessed to inherited from my parents the hair from my dad the skin from my mom 20 yrs.or more looking younger and to add slim and trim🇸🇽🇺🇸 GoTo Mars GoTo Mars 5 months ago Great thank guys! David Sinclair Jim Fife Jim Fife 5 months ago Yeah, Rapamycin inhibits mTor but Tacrolimus is a calcineurin inhibitor. Both suppress T-cells +/or B-cells, in high, frequent doses. Maybe that's the effect in the scalp? BlockjunkiesMC BlockjunkiesMC 5 months ago No mention of the positive effects of redlight on skin health? 2 Fer Ravenclaw Fer Ravenclaw 2 months ago Can u please talk about coffee and ADHD medication on aging and lifespan? 🥰🙏 Agnes Laufer Agnes Laufer 5 months ago Regular workouts, low carb diet with variety of veggies no fruits Taking care of skin on daily basis Drinking water 1 KitasakuOnline KitasakuOnline 5 months ago (edited) I watch the entire ad on these videos to support the channel more Hallie Coletta Hallie Coletta 5 months ago Love you two. Thank you. cjcj2010 cjcj2010 5 months ago Fertility also decreases because of lack of zinc and iodine (and other nutrients) from food, greatly negatively affecting fertility, thyroid, etc. Steve Y Steve Y 4 months ago "And then you have to put a lot of effort raising kid, It's not like an insect just let them blow away in the wind"😂 劍身仔 劍身仔 5 months ago Please make a video on how to restore vision and cure myopia🥺 2 Fiona.D Fiona.D 3 months ago I don't want science that tests on animals. I want to live in a world that respects their lives. It seems to me, so far as our own health and looks are concerned, we each need to take individual responsibility for eating well, sleeping well, exercising and moving our body EVERY DAY and for keeping a sense of calm in our lives. The majority of peoples lives would be so much better if they just made the simplest of adjustments, such as walking half an hour a day, eating more complex carbs (e.g oats for breakfast) as well as fruits, veg and legumes .. and also drinking more water and going to bed earlier. A lifetime of doing this has got to be better than waiting for science to create a pill or lotion. My vegan (plant based) Dad is now 80 and looks amazing. He's active every day, can still climb the roof to fix tiles like when he was a boy and can cycle 16 miles. He also always goes to bed early (around 10pm) and gets up early too (6-7am). He also eats lots of salad and veg, makes his own hummus and eats lots of healthy complex carbs. He makes other positive lifestyle choices too e.g. he doesn't smoke or drink or over indulge in any foods .. and the only vitamin pill he has is B12. He also has a super positive, kind attitude and his mind is sharp. As he's always done stretching and resistance and cardio type exercises daily (he was a builder) he was able to move house for me recently e.g. loading sofas on to the van etc. Again, if we want the rewards of a rich and enjoyable and active lifestyle we need to take responsibility, make a few adjustments .. and start seeing these healthy lifestyle choices as an act of self love and as a privilege not a punishment. Kräuterzimmer Kräuterzimmer 4 months ago Kudos to adressing female hormones too in this episode - u read the comments from previous videos! Talin Rowe Talin Rowe 4 months ago I hope you've both considered taking your massive following and have people volunteer to conduct the worlds largest and longest longevity research Ever End Ever End 1 month ago 31:44 is retinoids are retinol cream ? Is there a difference between retinol and retinol-a? Thanks anne williams anne williams 4 months ago Love the topic. Lots of info 1 J R J R 5 months ago Liked my Levels. Became a little addictive, checked like every 15 minutes🤭. wigglywrigglydoo wigglywrigglydoo 5 months ago Might be a little off topic. But anti aging seems to be a promising field for peyronies disease. Hu Mu Hu Mu 5 months ago So stoked just found This!!!! Linda Harwood Linda Harwood 4 months ago I'm Australian and I haven't seen any sunscreen dispensers on the beaches in Australia. If you come to visit an Australian beach please bring your own sunscreen 🏖️😊 marsery marsery 5 months ago (edited) So Dr Sinclair do you take catalase to fight white hair ;-)? And I suspect you've read my comments on a previous podcast as you're addressing all the points I've made : thanks! Ankush Sharma Ankush Sharma 5 months ago once more, let's go david and Matthew Nikki Schumacher Official Nikki Schumacher Official 5 months ago Everyone says I look so young but I feel old. Idk. My mother looks very young but she's not in good health either. We have arthritis issues- mine have been controlled largely with meat based and gaps diet. Sonny Matthews Sonny Matthews 5 months ago (edited) Can telomeres be repaired, if so how much does this change your epigenetic clock? 1 Alamnoor Sandhu Alamnoor Sandhu 1 month ago How does cold and hot exposure effect the skin ageing ? Like cold showers and sauna ? Caroline Duncan Caroline Duncan 5 months ago I’ve read that hylauronic acid causes cancer. Please can you address this maybe in next season? Thanks a lot ahmad khan ahmad khan 5 months ago One question @dr sinclaire . Will this be relevant that more we ejaculate shorter will be our lifespan ? In your book you mentioned that the species who reproduce very fast and more have short lifespan Sherry Boxall Sherry Boxall 5 months ago So excited for this one! 2 Cheree Wright Cheree Wright 5 months ago (edited) I believe David just said we shouldn’t use hand sanitizer in this video. Of course I want to know why. I’m assuming it ages the hands because it’s so drying and may even be absorbed into the bloodstream? MEI mei MEI mei 5 months ago thank you!!!!! David Sinclair Mariana Salles Mariana Salles 4 months ago A plant based diet helps a lot in having a healthy, active, cleaner life🌍🌱🙏🏻💪🏻 🧠 Chris OTC Chris OTC 5 months ago David Sinclair is maxed out on botox.. and definitely has had work done! 🧑‍⚖️ Bonnie Oliver Bonnie Oliver 2 months ago An intriguing series. So informative. As a scientist I appreciate your willingness to share your research to the public at large. Grazie. Jk Bee Jk Bee 5 months ago (edited) Can you please explain whether the protocols are safe for breastfeeding and pregnant women - eg metformin, fasting, also effects on fertility. reem souliman reem souliman 2 weeks ago Hello doctor! I have a question how to avoid Vit B12 deficiency if we take metformin with our meal Pat rick Pat rick 5 months ago Pound-for-Pound David is the best PhD. Fatima Freire Fatima Freire 5 months ago 👏👏👏👏👏❤️ K J K J 5 months ago What about consuming beta carotene instead of using topical retinol? I drink lots of carrot juice 🥕 Parker Reed Parker Reed 5 months ago great video! thank you. Dawne leturcq-whatley Dawne leturcq-whatley 5 months ago Thanks so much, gentlemen. Content great but hating the plugs for products or services where you do have some interests. 1 Michelle S Michelle S 5 months ago My grandma died at 84 she had a small sprinkling of grey never died her hair she used olive oil buybuydandavis buybuydandavis 5 months ago Is it better to cycle between growth and autophagy? Curious1 Curious1 5 months ago Is it possible to find out the best topical with small chain hyaluronic acid and reversitrol? bigblockjalopy bigblockjalopy 5 months ago I know 25 year olds who look older than Dr. Sinclair at 52. Impressive. That said, he does make a big mistake. Skip Dinner, not Breakfast! John Snitus John Snitus 4 months ago (edited) Fucking love this guy so much. David you are a hero. Fun Times Fun Times 5 months ago I missed the part where you're supposed to eat a tub of ice cream at midnight 2 Nica Mike Nica Mike 4 months ago David looks like he’s 12. Impressive. 1 Lorrain S. Robinson Lorrain S. Robinson 3 months ago i use topic retinol 2 times per week, should I stop using it? I got very confused at that part. GreenTara2010 GreenTara2010 5 months ago I bought the One Skin cream David mentioned. It got good reviews. WeirdAlSuperFan WeirdAlSuperFan 5 months ago If you're underweight and, say, under 35, is building muscle and strength training (and upping your calories/protein) really that bad for you??? ProductVisibilityTV ShoppingNetwork ProductVisibilityTV ShoppingNetwork 4 months ago Is there any evidence that these changes in diet can increase your testosterone levels and improve your sex life. If so, can you expound on those issues please? Dr. Delaney on Dreams Dr. Delaney on Dreams 5 months ago Where can we find more on how Infrared Saunas work? Since Dr. Roger Seheult published on MedCram "Light As medicine" we have daily SUNRISE BATHS (before 9 am) and we bought and assembled an Infrared Sauna after Rhonda Patrick's fabulous video on the topic that encourage healthy seniors to enjoy them for their many benefits. Seekingthemiddle Way Seekingthemiddle Way 5 months ago The fertility window for women is vanishingly small, and not always convenient for modern women. If humans start extending lifespan I wonder if fertility will last longer as well one day. Hope so. La Kid La Kid 5 months ago I think as a female i would have liked the same amount of a deep dive on skin as with male baldness. Seems like the guy In the cap speeded through the skin part then nit picked hair loss. Which is weird cause He could have a pod cast about HAIR LOSS itself??? 1 Yvette P Yvette P 5 months ago The only thing I do not agree with Dr Sinclair is the use of Metformin and Statin drugs. The neurological issues with these two drugs far outweigh the benefits of his NAD precursor supplementation and Resveratrol Laura Gitchel Laura Gitchel 5 months ago Yes to sexual health. Let’s talk about vasodilators:-) Jean Roberts Jean Roberts 4 months ago Bruises on fruit are actually a sign of high levels of antioxidants! Claudia Jap Claudia Jap 5 months ago David sinclair , is so cute and soft spoken. He is like a weird child , smiles very little🙂 Aleksa Aleksa 5 months ago (edited) I think way more research and attention needs to be funneled into estrogen and progesterone. Even if combined therapy of progesterone and Estrogen has been commonplace for over a decade, maybe 2? Healthcare loves to leave out women and so many of the functional medicine thought leaders I follow are men, and many motivated primarily by their own mortality. It's fine, but women watch you and learn from you too. I think you absolutely should lecture on it, be transparent if there is not enough info then let that be known and push to keep funding it's research. I love to hear women being included, beyond reproduction as well.* I enjoyed this ep and your work David. cearilin dubhlaoi cearilin dubhlaoi 2 months ago Please Please talk about Menupause more ...what women need to concentrate on at this stage to make life easier mentally physically and emotionally..its a really hard sad time ...xx much respect 👏 🙏 Y L Y L 5 months ago Thank you so much! doth4580 doth4580 5 months ago Prediction: In a couple of decades this guy is going to look accordingly old and he is going to do the same talks about how you can become younger. The worst thing is that some will still take him seriously. Edward Nino Edward Nino 5 months ago A question about red laser light, you mention the beneficial effects of red laser light, to be clear you mean true lasers versus red led lights of which there are numerous brands of red led devices. Erika Erika 5 months ago I would have been one of the women who died in childbirth if I was back in the times where assistance wasn't available. Not all women are built inside for bearing children. Solaris Solaris 5 months ago I believe that the 12 am sun, everyday, for 20 minutes, is the best due to max exposure to UVB (the one that produces VIT D). One question I have is: Is there such a thing as "sun ormeses" ? Joseph O Joseph O 5 months ago (edited) At around time stamp 50:58 David says Retinol Cream .5%. Did he mean Retinol Cream .05% as I have look and do not locate Retinol Cream at .5% 2 Natura+ Natura+ 5 months ago (edited) They covered a little on HRT. My question is what is the science on women taking HRT in combination of Sinclair's protocol on MNM, Resveratrol , quercetin, fisetin and Metformin and/or berberine. . Manuel Ojeda Manuel Ojeda 5 months ago I just turned 70 I punched my hand and it went down I one second. I'm super healthy. 1 Matthew Matthew 4 months ago (edited) Bit of a contradiction here with alcohol and an earlier episode about red wine and resveritrol. Didn’t David previously say he enjoys a glass of red wine but he’s saying here he’s given up alcohol? Some clarification please? Gerald Tong Gerald Tong 5 months ago Hi Dr Sinclair, with the near future age reversal treatment, will women be able to give birth after the age of 40 years old and above? cheekybastard99 cheekybastard99 5 months ago Can anyone speculate why the researches attempted to disguise Tracolimus for reversing graying? Jeff von Future Jeff von Future 5 months ago Hello! What about color light therapy on the skin? like red light therapy. I have seen other colors like blue, purple and green beeing apply with a mask Paula Ukena Paula Ukena 5 months ago THANK YOU SO MUCH 😊 Nate Nate 5 months ago Is it specifically lasers or is it also NIR and red led lights of a sufficient power density? Mcgragor Mcgragor 5 months ago (edited) Cr. Brad Stanfield just posted another video saying Resveratrol does not work, I really think you should respond to this. Just reading the comments people are questioning Dr. Sinclair's integrity. 2 laurie meunier laurie meunier 5 months ago So David you mention fasting for 3 days to upregulate autophagy. Is it just water or would athletic greens be allowed? Greater Goals Greater Goals 5 months ago Best color for David - this blue. Looks cool & younger Lea DiMento O'Brien Lea DiMento O'Brien 5 months ago what about DENTAL HEALTH? dental plaque can get into the blood stream via bleeding gums etc Have you researched that? 1 Abdelilah BENAHMED Abdelilah BENAHMED 5 months ago If I were bald I would never think about blaming my beloved mother for having transmitted to me the genes of alopecia.Instead I would be immensely grateful that she gave the gift of life with the grace of God. mitch becker mitch becker 5 months ago (edited) The true secret to increasing lifespan is a sweet denim button down. 1 Lisa Ray Lisa Ray 5 months ago What about red & near infrared light therapy for the face aging? Ever End Ever End 5 months ago How do i know how much metphormin to take? Or at least try to take. I remember David once said he takes 1g per day, I believe. bella bella 4 months ago (edited) Why your sounds quite low? It’s not my phone cause it’s fine and Loud on other channels, But l love you anyway Dr Sinclair you the Best thank you 😊 1 Renan Huguinin Renan Huguinin 4 months ago So retinol has a lot of benefits to skin and collagen production but also block autophagy making the skin age faster? How can i read more? I'm 27 and my skin is good, so i don't need retinol? Stacy Stacy 5 months ago Not sure about the nail observations ...if I take k2 my nail growth explodes ...but I don't think (unfortunately) that will correlate with my biological age? Von Sabido Von Sabido 5 months ago Imagine if they made an all in 1 pill Teddy Li Teddy Li 5 months ago The levels app sounds really interesting SydCar SydCar 5 months ago Everyone should be watching this!! d d 5 months ago I respect David and he's got good advice. But he literally looks older than he actually is. So does that mean he would just look even older if he didn't do all these things? Or none if this stuff is working? Darkhorse Darkhorse 2 months ago Collagen applied topically is ineffective as the molecule is too large to penetrate . 1 illy illy 5 months ago Can you guys talk about any down falls of fasting and woman (premenopausal). Since woman are cycle beings and are more sensitive to physical stress is fasting causing too much stress in a woman( Jakub Malinek Jakub Malinek 5 months ago It's a pity that levels or inside tracker are only provided in US and Canada. J Bird J Bird 4 months ago I bought AG, love it but couldn’t access Dr.Sinclair’s code for discount 🤷‍♀️🥺 Silas Askjær Midtgaard Silas Askjær Midtgaard 1 day ago The really Nice Co-host Matthew reversed his age so much, his voise started to crack again (48:08 in the video) Dr. Delaney on Dreams Dr. Delaney on Dreams 5 months ago NAILS? 1,000-5,000 mcg of Biotin (Vitamin B7) has transformed my nails that first yellowed, flaked, and softened in my 50s. My Dermatologist suggested Biotin at 300mcg daily for 3 months trial. Nothing. So I went to 1,000 mcg and saw good results in a month or two, then to 5,000 when the store only sold that. Now I see bottles at 10,000 mcg tabs! Is there an upper safe limit? in 2008 I saw a warning on a bottle on 1,000 mcg to stop taking before any surgeries because Biotin thins the blood. Since then I have not found any warnings, nor a doctor who can answer the question. So, we amateurs need help in dosing at different body weights, (please remember those of us who weigh 90 lbs. and are female) and dosing for different ages and states of health and inner age estimates. Most docs seem to go by estimates for 150 to 175 lb. males. I once dated a wonderful cardiologist from Lucca, Italy who loudly lamented how few docs in the US were attentive to these important distinctions. Any help you can offer to educate us would be so welcome, as is your site and your work together! Austin Myslinski Austin Myslinski 5 months ago Bringing back the 90's Levi jackets... 2 Reverse Aging Reverse Aging 1 month ago I see Matthew likes Austin Powers movies.... Humor is important to slowing down aging too! LOL Berit Qvarnström Berit Qvarnström 2 months ago What is the mechanism behind the common hairloss in elderly females? Scott Summerill Scott Summerill 5 months ago Didn’t Dave say on the very recent Huberman podcast that he drank? Not gonna go back to confirm but it was red wine. I believe. So … what changed? Tech Hindi Tech Hindi 5 months ago What about Glycerine for skin? Surprised not to hear about this ingredient which is present in almost every skin care product! Terry Orzechowski Terry Orzechowski 4 months ago (edited) I didn't get any useful, actionable information out of this for the first 10 minutes and 19 seconds. That is way more than I should have given it. Ryan Badeau Ryan Badeau 5 months ago I see Rogan and Huberman told Sinclair to get the SM7B. Marian R Marian R 2 months ago Is there more recent literature on topical retinoids and hair loss? That article is from 36 years ago- 1985. Lois Beauty Luxe Lois Beauty Luxe 3 months ago I enjoy watching men discuss this subject Malgorzata Krala Malgorzata Krala 3 months ago Would you be able to add the link to research about alcohol impact on ageing please? Gmgl1981 Gmgl1981 5 months ago How is it possible to get MNM and know that what you are getting is pure and of quality? Media Center Media Center 2 months ago (edited) it's very very odd that a well known doctor with millions of dollar companies need to add sponsors, Like a teen age Tiktoker Eva A. Eva A. 5 months ago Thank you so much 💓 Andreas Stuermer Andreas Stuermer 5 months ago This DNA test from insidetracker ... is it measuring the Horvath clock? According to all the CpG sites that Horvath uses? Yourcoach Bladimir Santos Yourcoach Bladimir Santos 5 months ago Does anyone knows where David is getting the supplements from? relaxnow2english relaxnow2english 2 months ago What brand of bone broth is the best, most pure, keto? Where can I get genuine wholesome/home made// bone -broth soup, without MSG? Which company is most PURE authentic? Asking for health reasons: Not interested in soup mixes. Thanks for your help. channel0001 channel0001 4 months ago Does athletic greens have heavy metals like the other green supplements? Veronika Veronika 5 months ago team retin A here! ❤ 1 J J 4 months ago Some of the advice, particularly related to skincare, is a bit too textbook. Go to reddit or other skincare dedicated channels on YT for interventions that work, and work well. Aiden Aiden 2 days ago I hope I'm not cursed. I am a female who has gotten to 49 and don't have my hormone levels baseline from youth, but am going to rush to find out. adrienne gellman adrienne gellman 2 months ago For women there isn't lack of sex drive!.What there is instead is potential partners they don't like or could care less about as people. Lea DiMento O'Brien Lea DiMento O'Brien 5 months ago what about REBOUNDING? A.k.a. TRAMPOLINE exercise which I hear is good for the lymphatic system Ez L Ez L 5 months ago Can you go through a blood test for us and tell what your biological age is Legolas Legolas 5 months ago What is better Reseevatrol or OPC? africanchina1 africanchina1 1 month ago starts in 13:00 Barbara Lanzante Barbara Lanzante 5 months ago What about bio identical hormone replacement for women that are going through menopause or who are in menopause? By doing this does it change the entire human body is a dangerous? Steve S Steve S 5 months ago Please devote more time to the eyes. Very interesting! Pmann Pmann 5 months ago Why is smoking bad? Is it the smoke coming in contact with skin? Is it the inhalation of chemicals? Is it the junk in cigarettes? Asking as an avid bong smoker. 1 Eika Jung Eika Jung 5 months ago Matthew saying he “poo-poo’d” this topic offends me. carlos serrano carlos serrano 5 months ago As of right now the age reversal isn't available for the masses only the elite of the elite. U can only stall it or slow it down.and you can do that with frequencies and molecular telomeres therapy that uses vibrations(frequency) can also reverse if you tune the frequency to the correct hertz. Any supplemental or medication can't alter the human genome 🧬 at least not by the ones offered to us.there's gene editing but can't stop the aging process just yet.again not for us but for the ones that have power and the ones that control technology. It's all about vibration (frequencies) morphogenetics manipulation. Samuel Samuel 5 months ago Great to see Fred Durst again. adrienne gellman adrienne gellman 2 months ago Please Google:sun exposure causes skin and eye aging.Also please Google:microneedling. RachelB RachelB 4 months ago I was wandering if NMN is safe to take with MSM?? 🙂 Peter Hicks Peter Hicks 5 months ago get somebody to do a painting of you and then put it in the loft ,it worked for bloke called Dorian Gray ! Craig Crawford Craig Crawford 5 months ago Sinclair really pushes his ideas but pooh poohs others. illy illy 5 months ago In what form and what dose reversetol would it be beneficial for woman to take for antiaging? Chantal Pique Chantal Pique 5 months ago What about Own Fat Injection for Filer into face or hands? d d d d 5 months ago which NMN brands do you recommend? thanks dr. Paul Sansonetti Paul Sansonetti 5 months ago keto or carnivore for blood sugar baths in borax and topical coconut oil/tea tree oil for the ulcers /biofilms John Coe John Coe 5 months ago Outstanding info Nieczerwony Nieczerwony 5 months ago I think that quite important thing hasn't been discussed and this silicon in terms of ageing of the skin and other tissues. Lea DiMento O'Brien Lea DiMento O'Brien 5 months ago I would think if you were researching aging you would study the microbiome, stool samples, digestive system...... Bob Bach Bob Bach 5 months ago interesting new info... thanks for sharing Dana Danaher Dana Danaher 5 months ago Can you please link the study referenced regarding alcohol and skin aging? TIA Nabila Ray Nabila Ray 5 months ago amazing info ,,green juices are a must ..i add protien to them ....😃 Blooming Health Booming Wealth Blooming Health Booming Wealth 5 months ago Sir I am learning Molecular Pathology Masters. I wish to work with you. Please contact me. dlb dlb dlb dlb 2 months ago I'm 78 and my skin pinch test was 1 second or less Metatron's Lamp Metatron's Lamp 5 months ago David Sinclair knows what he's talking about. He's 75. T Gulley T Gulley 2 months ago Hello, What about botox for eye twitching. Do u know of this? What is your opinion? Thank you for this podcast, I am learning so much. Adria B. Adria B. 5 months ago I have a question!!!!!! Do any of this anti-aging pills cause any harm to your stomach overtime!!!!!! Please let me know, I'm already taking vitamin d and k daily, and hair supplements. frank moreno frank moreno 5 months ago (edited) Comments on astaxanthin for skin protection and, possibly, aging, if you two would. Sam Ford Sam Ford 4 months ago Question... If our nose and ears don't stop growing all of our lives, in the future when we double our life span will there be millions of people with massive conks and lugs at age 160? Libby Collins Libby Collins 3 months ago Is there research on effects of taking NMN and resveratrol on thyroid function with Hashimoto Thyroid Disease and low thyroid? TALKSiCK TALKSiCK 5 months ago What do you do if u had overexposure to retinoids? Vitamin a I don’t want to make me worse Nostalgia Nostalgia 1 month ago So many people are dying from lack of nutrition and from war, but here is this guy trying to just prolong his life and look young. How is Kim Kardashian seen as vain but not this guy? battledino battledino 5 months ago Does taking collagen pills works to look younger? Joan Maloney Joan Maloney 5 months ago I question your statement thhat Botox and lessoning wrinkles can enhance your social life. Any studies on that ? I love your podcast xenosonic xenosonic 5 months ago Born and raised in Australia and never once have seen free sunscreen at the beach. Joe Blow Joe Blow 9 days ago I suspect micro needling will help. Not shure but every since ive heared about it ive seen old people on the telly that used to look lile shit but now look naturaly young again. Micro nedling makes sence to me because you "punch out" old damaged cells and force the body to tranplant and fill the holes Jason Clowrey Jason Clowrey 5 months ago Is Levels only available in the US? Jose Ernesto Bello Ravelo Jose Ernesto Bello Ravelo 5 months ago Thanks you guys! Ticketforlife Ticketforlife 5 months ago (edited) Minoxidil almost killed me lol. Please look at the research of Rosemary oil and it's effects on hair growth compared against minoxidil5%. Seona Seona 3 months ago I embrace my "silver"hair🤗😊 SL SL 5 months ago Do we know if he uses XR Metformin? Reputable brands of NMN and Resveratrol? Hard to find 1 gram in few capsules and COAs can be forged or old. efivos efivos 5 months ago 46:38 Dr Sinclair, I have heard you many times claiming that it's 20% genetics and 80% epigenetics. Why is it different on this subject? Donna Oliver Donna Oliver 2 days ago My nails grow more quickly when I am on holidays. Jennifer McCullough Jennifer McCullough 5 months ago O another question can you reverse ovaries that have been damaged by chemotherapy and tamoxifian Lea DiMento O'Brien Lea DiMento O'Brien 5 months ago I think VOLUNTEERING keeps you young too. birigik birigik 5 months ago I'm 53 and skin pops right down. Gosia Byliniak Gosia Byliniak 5 months ago Thanks guys, love you 😘 Jamie Quigley Jamie Quigley 5 months ago The interviewer is painful to listen to. Great info from David as ever. 1 Helen Duyvestyn Helen Duyvestyn 5 months ago Was the early hair loss not related to Accutane? Kelli Inman Kelli Inman 5 months ago Surly people mention you look like Christian Slater! Your videos are fantastic👍🏻 Marina E Marina E 5 months ago Actually it was pretty prevalent for women to have children over 40 post war in the UK before it became fashionable to bang on about it. Sun Li Sun Li 5 months ago Oh he looks like a college boy in this episode. Amazing,, 2 Janet Bederman Janet Bederman 5 months ago So can I add some resveritrol powder to my lotions? Manuel Ojeda Manuel Ojeda 5 months ago My rooster pecked my leg, cause he was hungry, and I'm already healed. Steven Underwood Steven Underwood 5 months ago (edited) Australia - all beaches have free sunscreen???? What absolute nonsense. How can we trust anything Dr Sinclair says when he is willing to make such obviously false statements? I find Dr Sinclair's material super interesting, but after that comment, I'm starting to question whether or not his statements and claims regarding health are reliable. 1 Sara Heart Sara Heart 2 months ago My 100 year old grandmother is laughing at this. Yin TS Yin TS 5 months ago NmN can cause cancer ? Heard a lot about this problem. I have been taking nmn for few months. Kristy Kaley Kristy Kaley 5 months ago Can you use Oneskin Os-01 if you get fungal acne?! Toni Officer Toni Officer 5 months ago 63 skin going back in 1 second ! Patrick Day Patrick Day 5 days ago (edited) Lol did she try Melanotan when looking for skin peptides. You never know what might come up with that one. 🤣 ___ ___ 5 months ago 31:04 collagen powder manufacturing requires using a lot of chemicals. it is more harmful than beneficial... 2 Buddy Revell Buddy Revell 9 days ago At some point those youtubers promoting techniques for appearing younger are themselves going to have to look very young for their ages. Otherwise, few will buy what they are selling. Where's David-Paul? Where's David-Paul? 5 months ago I keep putting this in comments but nobody has responded how about low level cyanide for killing senescent cells ie eating almonds. Surely they are weaker and likely to die. Mary Fuzzell Mary Fuzzell 4 months ago David S. seems very sincere; however like buying into fanatical religion I approach all of this with interest and selective caution. On collagen supplements or powders., You say it can't hurt but not proven. On nail growth you say it is an indicator of biological age. Since I've taken vital proteins in my coffee ( two scoops a day). my nails grow like crazy and are hard for the first time in my life. Am I biologically younger? That, I don t know.. but the collagen powder is doing the trick of giving me healthy nails and hopefully bone density . Yvonne Sanders Yvonne Sanders 5 months ago Absolutely no woman in the UK will have any idea what their hormone levels are. 😂 it's bad enough trying to get hrt. But bless you for thinking of us. You realise we are 50% of the buying population? Jose Cunanan Jose Cunanan 2 weeks ago I donate blood plasma to the red cross twice a year.. Will this have an adverse effect on my own health? AJL AJL 3 months ago Why is it not talking about Radio Frequency device and Microcurrent device for removing wrinkles, lifting the face, getting rid of eyes bags? These are most important for women, boldness isn't the essence of issue. Dr Sinclair please talk about those devices nowadays millions of women even men are using the devices. Thank you. Monica Zamudio Monica Zamudio 1 month ago Is retinol safe while being pregnant? Nilay Izmire Nilay Izmire 5 months ago (edited) Dr.Sinclair! I think alcohol and soda has aged you faster. How you didn't know it was bad. At university you've studied Alcohols. Emmanuel Trejo Emmanuel Trejo 5 months ago Go Sinclair! Ilhan Ilhan 5 months ago Any one here tried collagen for anti ageing? Or any of the other stuff here,. Penelope Frias Penelope Frias 2 months ago I have a macular degenerative disease, when can we expect the lab vision experiments will be available for people? Alex Calderon Alex Calderon 4 months ago Is there a peptide for facial sagging? 4Free 4Free 5 months ago OMG how was i not subscribed to this. Rosy Loves Learning Rosy Loves Learning 5 months ago 🙏🏼 shay stern shay stern 5 months ago never cared about cosmetic aging, but it's a great industry for folks wanting to get rich. who cares about wrinkles, gray hair? SO WHAT? 1 Natasha Kramer Natasha Kramer 5 months ago Where can I buy "one skin" cream? The one they talked about by Dr marryane OZ OZ 5 months ago proly a dumb question, but do cbd and or thc have any benefits/negative impacts? obviously smoking is not good but now we have edibles, vapes,oils and so on Malgosia UR Malgosia UR 5 months ago more about menopause pleaseeeeee Pearl Charkow Pearl Charkow 5 months ago Please share which sunscreen you use? Thanks David West David West 5 months ago (edited) We don't have free sunscreen on the Sunshine Coast:-() also may I ask where you buy your Resveratrol... Ciarog Ciarog 5 months ago Does castration help animals live longer? My veterinarian told me no. 1LaOriental 1LaOriental 5 months ago What about Castor oil for hair growth? General-Economics General-Economics 5 months ago Thank you Sir 1 Ana Kamhi Ana Kamhi 5 months ago I’ve seen some mnm reviews where some women get their period back after menopause sketchur sketchur 5 months ago How old are Dr. Sinclair's kids? When will they start looking older than him? lol Thomas Gabriel Thomas Gabriel 4 months ago I really wish that Matthew LaPlante had asked Dr. Sinclair if he has had any botox treatment for his forehead and crow's feet area? Ethan Cowart Ethan Cowart 5 months ago (edited) i wanna hear david talk about some 5 amino 1mq .?? that activates sirtuins well Navya Navya 5 months ago Does minoxidil work on women too? Jason Keck Jason Keck 4 months ago Anyone know about the oral bioavailability of hyaloronic acid? They didn't touch on that. 3 months ago (edited) Wonderful information but the constant interruptions by the interviewer is making this incredibly difficult to follow. He can’t shot up for some reason 1 Fernando Almaguer Fernando Almaguer 5 months ago So how do we reverse greys? 2 Mango S Mango S 5 months ago Can you talk about the use of weed impact on aging? karma karma 4 months ago Anyone know why Athletic greens doesn’t contain vitamin D? 🤔 Erica Kabbeko Erica Kabbeko 8 days ago Will inside tracker give you a baseline of hormone levels? I P I P 5 months ago Couldn’t find anything on free sunscreen on beaches in Australia. Is this true? Lucifer Lucifer 5 months ago In which year will the madicines will be completed that would extend my lifespan by hundreds of years?like how much time would it take more... I'm 13 and you better do it fast.,..plssss 1 TKNZD WORLD FIRST IDENTY LINKED NFTs TKNZD WORLD FIRST IDENTY LINKED NFTs 2 months ago He is not really interested in anti aging of skin but super interested hair loss Wesker 8623 Wesker 8623 1 month ago cosmetic aging Suddenly david has a massive female following 😂 Delia Ocampo Delia Ocampo 5 months ago Also eating healthy active no worries not smoking good mindset serene🇸🇽🇺🇸 Cesar Ortuno Cesar Ortuno 5 months ago I honestly come to this podcast to listen David Sinclair about the science and the studies but Matthew really annoys me speaking over David. Im love with this podcast but maann Mathew should just stick with asking the questions and being funny, pls let David talk on the science and the studies Adrian Hoyle Adrian Hoyle 1 month ago Is inside tracker available in the uk? Mario Mario 5 months ago No offence but does the on average longer live of castrates really have to be something biological? With less testosteron comes less risk taking and agressivity. Also i would bet on that those people do not get into hardworking jobs. And the most importand, they will not affected by the stress that women are causing for us. :) So this people are avoiding like a 1000 situations that makes a mens live shorter. Iron Maiden Fitness Iron Maiden Fitness 4 months ago I think eunuchs live longer because they don’t have children to stress them out! ☺️ sf sf 5 months ago 57:11 - "What doesn't kill you mitochondria." - Patent that shid ^^ CallOfDutySniperzzz CallOfDutySniperzzz 5 months ago I'd give this guy 38 max. He looks around 30 and even young looking for 30. Not 50 daddyshoneygirl USA daddyshoneygirl USA 5 months ago As Dr. Sinclair is a total hottie, I am a believer. Something is working for him, it's worth trying! dna dna 2 months ago what types of laser work, the price span is huge, any tipps? Vincent Sherlock Vincent Sherlock 5 months ago Just take Epithalon and a lot of hyaluronic acid. 1 jennifer Zengineer jennifer Zengineer 5 months ago Is the sunscreen reef safe? How is that not your first question? Can’t live forever on a dead planet 🙄 Jelena Jelena 1 month ago Who got into menopause in late 30 or early 40?!!!! It's in 50s. Damn obmitty1 obmitty1 5 months ago David looks weird,,,, forhead has dropped, eyebrows lifted…starting to look creepy not young 1 Jccp Jccp 5 months ago Why don't they go straight to the point? 2 Kira Schofield Kira Schofield 5 months ago Nadia skincare have facial creams and serum with NAD. Is there any benefit to delivering NAD directly into skin? Jade Zee Jade Zee 5 months ago the best thing you can do for your skin is take vit c..........every 4 hours....8 grams a day is super.... Ed Rock Ed Rock 5 months ago These guys must be the life of the Party. Higher Thinkers Club Higher Thinkers Club 5 months ago 23:05. FREE SUNSCREEN ON AUSTRALIAN BEACHES = Death to The Great Coral Reef….Another subject I know- but really poor for fish and the eco of the water Matthew Hugh Matthew Hugh 5 months ago This should be an interesting video Kelly Heather Kelly Heather 4 weeks ago My nails never grow they never grew even when I was little Aaron Ward Aaron Ward 3 weeks ago What I don't understand is that people who have never smoked never drank alcohol fit as a fiddle and drop dead of a heart attack or get cancer so I don't know why he's saying you can live up to say late 90s if you do what he says my advice enjoy life live life to the full eat a varied diet if you want a bit of cake have some only live once in this life. Paula Archuleta Paula Archuleta 2 months ago What about Coconut and Olive oil on skin? shilpy malhotra shilpy malhotra 5 months ago After how many hours of fasting does autophagy kick in? Dhaval Talati Dhaval Talati 5 months ago What is anticipated by oral use of Hyaluronic acid Maria Maria 1 month ago It is seldom for the general public lets see the exemple of Mariana Boroni P14 cream: 50ml (which you can not use for your full body) >150$ Ram Barlev Ram Barlev 3 months ago what are the risks of long term HRT therapy Super Heroes Super Heroes 5 months ago 27:49 first David Sinclair meme Dan the Gypsy Dan the Gypsy 5 months ago I know this doesn't pass the three sieves, but David Sinclair looks like a 50 year old mom trying to look hip with their daughters college friends coming over. Nnn Sss Nnn Sss 5 months ago Please, what is you explanation about Hunza Valley people in Pakistan, they live healthy up to 120 years??? Justin Furuness Justin Furuness 5 months ago Please comment on the YouTube video discussing rasveritrol and debunking it, showing your huge conflict of interest, by multiple other esteemed scientists. Sunny Elizabeth Sunny Elizabeth 5 months ago What Reservatrol Supplement do you recommend? Joseph O Joseph O 5 months ago (edited) To David or who the person reviewing the posted comments. You have the trolls posting about investments along with contact information. Could you try to block clean up. There are where 17 postings about investing as of 9:30am on 02/09/2022 1 Reverse Aging Reverse Aging 2 months ago MX$49.00 Thanks! Monica P Monica P 5 months ago Very, very sketchy info on the menopause. You did not even mention the importance of using body identical hormones. Then when you talked about hair loss it was from a male perspective again. Women get thinning hair too, but the treatments are different. Just be honest and call the show MALE Lifespan. You're obviously not interested in women 1 Levi Sinner Levi Sinner 5 months ago He's great but I can't stand his monotone. Had to listen to parts of this podcast several times to pay attention to what he says Tara Leigh Tara Cumming Tara Leigh Tara Cumming 5 months ago How do you feel about face lifts? marisol cardona marisol cardona 4 months ago 🤔I wonder if we reverse aging will women body defer going into menopause until much later in life. Hmmm Andrew Ross Andrew Ross 5 months ago Thoughts on intranasal NAD+? Maryam Mihanyar Maryam Mihanyar 1 month ago CA$2.00 Thanks! The never ending journey of life! The never ending journey of life! 5 months ago So often Matthew cuts David off! We want to hear it all. So stop it! SVP Suzanne Harry Suzanne Harry 5 months ago So where are are these long living people to go where's the room on the planet ? What about meaning and purpose in life? 1 MiraAI MiraAI 5 months ago ❤️❤️ 1 DavidSinclair #Longevity #BrainHealth The Science of Keeping the Brain Healthy | Lifespan with Dr. David Sinclair #7 237,504 viewsFeb 16, 2022 David Sinclair 209K subscribers In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep. #DavidSinclair #Longevity #BrainHealth Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Levels - https://levels.link/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Lifespan podcast website: https://www.lifespanpodcast.com Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsincla... Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclai... Stay up to date with David's work to democratize biological age testing and insights: https://www.tallyhealth.com Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante Timestamps: 00:00:00 Introducing Episode Seven: Aging of the Brain 00:04:39 Thanking the Sponsors 00:07:38 Ex-differentiation as a Driver of Aging 00:09:22 The Brain Ages Slowly 00:14:17 Cognitive Function and Plasticity 00:17:44 Three Longevity Pathways: mTOR, AMPK, and Sirtuins 00:23:26 Plant-based Diets and B-vitamins 00:28:32 Homocysteine, Plaque, and Vasculature 00:32:35 Fatty Acids 00:35:48 Physical Activity 00:39:14 Metformin 00:46:02 NAD Boosters 00:50:33 Increasing Blood Flow 00:53:20 Sleep 00:58:02 Overall Message: Keep your Brain Healthy 00:58:50 Next Week’s Episode and the Future of Medicine 01:01:21 Options for Subscription for Support Links: The cerebellum in the brain ages slowly: https://bit.ly/3JC9CLL Neuronal cells have a lower epigenetic age: https://bit.ly/3HVZsVA Sirt1 regulates aging in mice: https://bit.ly/3sGZPNC Mediterranean diet and brain health: https://bit.ly/3uUpYuL Mediterranean diet and dementia risk: https://bit.ly/34Igp7H Aerobic exercise improves executive functioning: https://bit.ly/34Dv5oJ Exercise and mouse models of neurodegenerative disease: https://bit.ly/3516IRn Strength exercises elevate the expression of BDNF: https://bit.ly/3GTLqCs Metformin enhances cognitive ability in fish: https://bit.ly/3sLtWn2 Alzheimer’s disease and metformin: https://bit.ly/3GSdTJ5 Metformin use correlates with a reduced risk of dementia: https://bit.ly/3GT0KPO NAD boosting and Alzheimer’s disease: https://bit.ly/367C2P2 ALS, nicotinamide riboside, and pterostilbene: https://bit.ly/3Bm2VKN Vascular aging and NAD in mice: https://bit.ly/34Uemgx In mice, overexpressing Sirt1 in the brain extends lifespan: https://bit.ly/3HNRyh3 Sirt1 ameliorates amyotrophic lateral sclerosis in mice: https://bit.ly/3LvUWiO Sirt1 protects against Alzheimer’s disease in mice: https://bit.ly/34KZXUe Sirt1 and neuroprotection in a mouse model of Huntington’s disease: https://bit.ly/3BqymDJ Sleep loss reduces lifespan in flies: https://bit.ly/3Jt6BgA A single night of sleep deprivation increases amyloid-beta: https://bit.ly/3uSNGaU All-cause mortality correlates with sleep duration: https://bit.ly/3rQl14f Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. Chapters Featured playlist 8 videos Season 1 David Sinclair 912 Comments rongmaw lin Add a comment... J2.A.M.p Thomas J2.A.M.p Thomas 5 months ago I don’t typically comment, but wanted to confirm that I appreciate Matt’s role (cohost) in this podcast. He tends to ask the very questions I have as a listener. 278 19Jetta 19Jetta 5 months ago I know I say it almost every week, but thank you again for doing this podcast. I am aware it takes your time and effort and no doubt you have lots of other things you could be doing. This is just an incredible resource! 157 Mohandas Gandhi Mohandas Gandhi 5 months ago "Today we'll be talking about the most important organ in the body, the brain." -David's Brain 64 mitch becker mitch becker 5 months ago Main takeaway, "Without a functioning brain, we are really quite useless." -Dr. David Sinclair. 105 sciencensorcery sciencensorcery 5 months ago Folic acid is not B-12. It's the synthetic form of folate, which is B-9. Many people are unable to properly utilize folic acid and need to take folate — but some people also need that folate to be pre-methylated. And others can react poorly to methylated folate (I experienced this myself a few months ago and the effect was staggering). It's a bit complex but worth looking into before you supplement (or if you start and don't take to it well) so you know which form you need! 122 Sheila Bella Sheila Bella 5 months ago What a great episode! Thank you both! I have to agree with the others who commented that MATT’s role in this is KEY! I never comment but I just had to say how I have an easier time learning this stuff because of his participation. 27 Pops Pops 5 months ago I feel so blessed to have found this podcast at 24, thank you both tremendously🤟🏻 29 Jeana Shchuchinov Jeana Shchuchinov 5 months ago I love your podcast, I can’t get enough. I was happy to hear you are going to have a season two lol 24 Aman Sharma Aman Sharma 5 months ago What do we know about lifestyle protocols not related to diet/sleep and how they age the brain? For example reading, spaced repetition, music, cognitive training, new experiences etc? Andrew Huberman’s episode on how play impacts plasticity was really interesting, so I’m curious how this all ties into ageing. 12 palden palden 5 months ago I am 58. Most of my years, after my 'teenage slim time', I was about 10 pound overweight. Around at 45 I developed some knee pain for many years and like so many of my pals, I thought it is just the body worn out because of the hard work as a nurse. So, it is just normal life...! But then I discovered the Ketogenic diet, and after 2-3 weeks my knee pain was gone and never come back. I almost never experience ANY pain at all in my body. If I tell this to my oldest sister, 62, that she should stop eating sugar and do low carb eating, she screams at me: "My body, and knees are worn out, nothing can bring it back!!". She just don't believe me, that the sugar and carbs is the ONE who give the inflamation and the pain, AND it is reversable! It's sad, that almost no one knows, that with eating low carb and no sugar, all the inflamation will be gone and one will feel normal again!! It should be called out from the Rooftop! 26 Ceci Palacios Ceci Palacios 5 months ago Great podcast! As a 68 years old my focus in healthy aging! Thus, I completely agree with Dr Sinclair said that we need to take care of our brain not only for us but for our family as well. 34 SirGolfAlot SirGolfAlot 5 months ago (edited) Dr. Sinclairs' videos are an inspiration. I was exercising, fasting, eating right, and taking supplements until the spring of 2020. Time to get focused on longevity once again. 11 stephen lucier stephen lucier 5 months ago This is amazingly informative, please don’t stop at 8! 16 Frazer Roland Frazer Roland 5 months ago I have read the book Life Span twice. I have watched most of David Sinclair's Youtube clips and interviews. I have given several copies of the book as gifts to friends. I have been following David's recommendations to improve my overall health for the past two years. However, witnessing how "religiously" David defends the use of Resveratrol despite all the new research studies that say the opposite, has made me question the "objectivity" and "authenticity" of David Sinclair as a scientist. I have no doubt David Sinclair is a great businessman. "Objectivity" is a true characteristic of a "real" Scientist. 42 Sunshine City Personal Training Sunshine City Personal Training 5 months ago Really enjoying the progression of these, excited for the next episode! 22 HardForking HardForking 5 months ago The best podcast I've found. You guys are fantastic, please keep this going. I've followed David's works for a number of years and put him right up there as one of the best humans we have on this planet. 16 Scott K Scott K 5 months ago Off topic, but I sure wish David would take the time to respond to Brad Stanfield's concerns about Resveratrol, namely that its efficacy as a longevity molecule has yet to be reproduced outside of Sinclair's lab (even by the ITP,) as well as concerns over possible dangers of long term use. Brad has been respectfully and patiently making videos and sending tweets to David about this for years, and so far, all David can muster is a couple dismissive & passive aggressive tweets. I'm glad it's decisive in David's mind, but us normies would appreciate some clarification, as it seems that Brad has a case here, and that David is being intentionally evasive. 19 Michele M Michele M 5 months ago (edited) I've been vegan for 20+ years. B12, not folate is definitely the most important to supplement with for brain health on a vegan diet. Permanent damage to the nervous system can happen with prolonged deficiency. For Omega-3s, the recommendation is 1 Tablespoon ground flaxseed per day or to take algae-based supplement for vegans. The algae-based supplements are expensive but more reliable than flaxseed. 14 Yayang Tapir Yayang Tapir 5 months ago Mathew is looking younger day by day....I think he is listening to david to start all the supplements. His collection of hats is awesome...😁😃 11 Claudette Sechler Claudette Sechler 5 months ago Just look forward to your podcast..it is so innovating and love hearing about the wonderful things about the health field that I can apply to myself! Just wish I could have dinner earlier instead of later but it is a special time to enjoy a great meal, glass of wine with my hubby and chit chat, laugh, listen to great music..that’s a great health fix for me!! 4 T.J. Robertson T.J. Robertson 5 months ago I look forward to watching these podcasts. Thank you for sharing your life’s work 💙 Alice Clark Alice Clark 5 months ago Thank you for making this podcast. If you guys continue with the podcast, I would greatly appreciate further elaboration on this topic. I am only 29, but my brain has deep white matter lesions, which are very uncommon at my age, but very common in the elderly. If you guys could explore the research on this topic, it would be greatly appreciated. I've been looking into as many papers as i can find on the topic, but I don't have the same access to the journals that you have. Thank you COACH Brendan COACH Brendan 5 months ago I always enjoy listening to Dr Sinclair discussing Longevity strategies, and applaud him for his work. Without criticizing him, I just want to draw attention to the discussion on B vitamins. At time stamp point 20:26, Dr Sinclair mentions that Folic Acid IS Vit B12 (cobalamin), which it is not. Perhaps his colleague should do a final fact check with him before the interviews, as in this case particularly, a pure vegan may be mislead into believing that they get sufficient B12 by virtue of them obtaining folic acid from their diet, YET, B12 is not bioavailable from any plant based sources, the few that may have it, nor even gut bacteria. B12 has to be supplemented, or derived from animal sources. 3 Sandra Thomas Sandra Thomas 5 months ago I was extremely impressed by this podcast. I learned a great deal of new things. I would love for you to follow up another podcast series. Chris Grant Chris Grant 5 months ago Please can you respond to Dr Brad Stanfield regarding resveratrol. He has made a few videos on this. Thankyou! 29 Dede Koll Dede Koll 5 months ago yes..please keep going with this podcast! It is so very important for us all. 1 Hana Hana Hana Hana 1 month ago I had hemoptysis 2019 it went away, last week I was having same symptoms so my Dr wanted me to get CT Scan to see what is going on in my lungs. So after I got the CT Scan I got neck pain and inside my left ear feels wierd. 20 hours passed since I had the CT Scan and I still have neck pain. I am very worried about radiations. I would love if you tell me what kinda of health food or vitamins I can take to get rid of the radiations. Thank you. Jean Claude Charles Jean Claude Charles 5 months ago Thanks a lot for these informations I can use to better myself, and for this huge service you're doing for humanity. You're a GOD inspired Soul. 2 monster paw monster paw 5 months ago Probably going to need to watch these 100 more times 🤯 Thank you for making these videos 🥰🙏 1 Paige Walker Paige Walker 4 months ago This episode was the one that finally got me to share this with my parents- the others were super inspiring to me, but not enough to make me feel like my elderly parents might actually take action. "The Average onset of dementia is 80 years old" - this episode made me feel like I'm doing a disservice NOT to share this with my parents! Thank you for making this info available to the masses! bigpicturegains bigpicturegains 5 months ago Practical takeaways you can implement immediately: Get good quality adequate sleep, exercise, eat well and ensure you are getting enough essential fats. 9 Stephen Young Stephen Young 5 months ago As an extremely busy professional and getting a little older, I enjoy learning about avenues that could help keep me optimizing my overall function/performance. Great podcast and the 2 hosts work really well together. 3 Mum2cuties Mum2cuties 4 months ago (edited) I’m an optometrist and I’m glad you emphasised the importance of an eye examination to assess general vascular health. 1 LCarefortheworld LCarefortheworld 5 months ago Thank you for doing the podcast! Feeling lucky I get these incredible information from the source I can trust! 1 Shelley Huskey Shelley Huskey 5 months ago David you are a special person! Thanks for everything you do. I have learned so much from you and your books. 6 Isabelle Ebel Isabelle Ebel 5 months ago Thank you so much for this great podcast! would like to know if it is ok to take Metformin and Resveratrol with the same meal all at once or would this reduce/inhibit the positive effects? 5 Frances Torrey Sirdevan Frances Torrey Sirdevan 5 months ago Best podcast ever. Love and appreciate the work you both and your team do and share. Thank you all!! A question about fasting for David: what do you prescribe for your children? Is one meal a day your recommendation to anyone of any age? If not, what age do you recommend starting that protocol? Additionally, I wanted to share that algae oil is a perfect vegan EPA/DHA source/supplement that circumvents the fish oil route. In fact, it’s what the omega 3 rich fish consume too! Highly recommended! 3 max adams max adams 5 months ago I have enjoyed your series very much. Thank you for the information. I would like to hear more about peptides if you do future podcasts. Rahul Rahul 5 months ago (edited) It would be Good If you Guys could Give 1-2 Daily Simple Practice at the end of each episode related to that topic which everyone can follow since not everyone can afford various drugs,tests n medicine etc. 3 Felix Sosa Felix Sosa 5 months ago Something I've been wanting David to take a shot at answering: what is (roughly) the appropriate age to begin with some of these interventions? For example, should I start taking supplements (NMN, Resveratrol) at 30? Late 20s? Late 30s? Or should all of these questions be determined by blood tests? 1 Calvin Scott Calvin Scott 5 months ago Thank you guys so much for doing what you do! It’s really mind opening learning from you Mr. Sinclair. I have one question that you may be able to shed some light on. Is any kind of intermittent fasting acceptable if one is missing their gallbladder? 1 William Nunn William Nunn 4 months ago thank you david for the advice on NMN. I am going to get on this quick, as i have chronic insomnia at the moment, from mental health. i exercise with HIIT and calisthenics. i take zinc, vitamin d and ashwaghanda but realise this is not enough at the moment. 1 Shyrine Kessentini Shyrine Kessentini 5 months ago Can you please do a podcast about repairing the cells in the body caused by cancer treatments, stress, radiation…thx 9 Jona Halldors Jona Halldors 4 months ago Love your episodes! such a great information you are sharing. nema znachenie nema znachenie 5 months ago I recently read viagra reduces Alzheimer’s by 70% and it could be to do with increased blood flow. If you ever do brain health update video it would be nice to touch on viagra. Thank you 2 Esther Jaedi Esther Jaedi 3 months ago Amazing podcast. Yes, I’m enjoying listening to all of your videos and at the same time gaining so much knowledge with coping with longevity n living a healthy and productive life. Thank you immensely. Earvin Ealy's Science, Technology, & Finances Show Earvin Ealy's Science, Technology, & Finances Show 5 months ago Thank you Dr. Sinclair for this information. All of your work is interesting but this reverse aging gene therapy is truly awesome. I am a huge fan. I saw your research on regrowing the optical nerve. I am legally blind due to my optic nerve being injured. Me and several blind people I know are very interested in your research. Is there any way we could do some type of phone interview for my youtube channel. I know you are super busy. We watch all of your interviews, but would love more information on how your research could help the blind. ritim ritim 5 months ago one of the few person on youtube that i deeply respect , thanks David for all of fantastic work and sharing to public. 6 Jane Lessa Jane Lessa 5 months ago Special thanks to Dr. Sinclair for delivering true science to our homes. I love neuroscience, so this is a fantastic episode!I Also would like to comment that the conversation format is great. Matt does a really good job. Tks everyone that makes this happen. 6 Ligia Sommers Ligia Sommers 5 months ago (edited) Best podcast !!! And I study many of them !!!! 🙏🏻✨🌹🌟🌟🌟🌟🌟 I am using AGreens and will check the others 1 Vicky Daisy Vicky Daisy 5 months ago Love both of you and your podcast. Thank you for making it happens. 1 andrew feuerstein andrew feuerstein 3 months ago Incredible information and I absolutely love the tandem here. You have my vote for WAY MORE CONTENT WAY MORE. You and Andrew Hibernian need WAY MORE CONTENT. I literally listened to all of your videos and his in less than 3 days. Can’t get enough abe rezz abe rezz 5 months ago I just subscribed to Dr S. channel.. having followed his lectures in the past .. thank you for the awesome stuff.. Brenda Spalding Brenda Spalding 4 months ago David I’ve seen you on Joe Rogan’s podcast. You’re one my favorite guest. I’m so happy that you’re doing your own podcast. I love Joe but I love him more when he has people like you on. I’m a fan. I hope you keep it going. Dusty Carpenter Dusty Carpenter 5 months ago (edited) I love this casual, engaged and authentic conversation. I'm more a creative writer/philosopher than a scientist. But I thank god for good scientists like these two. I think we're coming into a better age -- the age of conversation (which has always been my greatest teacher), wherein the sound bite media slowly, and quite painfully, dies. 5 qski1 qski1 4 months ago Looking forward to the next season, please continue! I would be interested the most in the effect of excercise (various types/cardio/weights) on aging. Melissa Share Melissa Share 5 months ago This podcast provides so much beneficial information to help reverse aging with easily accessible protocols and regimens. Fisetin is one supplement that has not been discussed yet and I am interested in knowing if you think that it may be beneficial for reversing age or age related degeneration? I know that the Mayo Clinic is currently running studies on this presently and I am interested in possibly adding this to my regimen. I would appreciate your thoughts on if it may be effective and if it is safe for humans to consume? Thank You for sharing your knowledge! 4 Michael Tegler Michael Tegler 5 months ago David and team, Thank you for the continued commitment to optimizing life. A discussion on the Microbiome would be tremendous as I have struggled with GI issues (IBS-C) and believe I have been suffering with invasive candidiasis as I have recently taken fluconasole which provided relief not only in my stomach but also caused the pain and stiffness to go away from joints, back, shoulder, etc. I am 49 yrs old and have taken many antibiotics throughout my life predominantly for sinus related issues which may have caused this condition of excessive candidiasis in my body and am curious to know if there is a way to restore the microbiome and healthy bacteria to optimal levels without Fecal Matter Transplantation as this is not readily available in the US. I'd also be inclined to go away to a clinic of sorts for 30 days if you know of one that would provide the structure and support to restore the microbiome. Thanks again for all of your dedication and work! 7 George Rodriguez George Rodriguez 5 months ago Thanks for doing this podcast. Very good information, live changing. Jawad Karim Jawad Karim 5 months ago A Big Salute for David Sinclair. 3 Altiaris Suralis Altiaris Suralis 5 months ago Thank you Dr. Sinclair, been following you for a while. 👍 Recently, there’s been some debate and pushback from Dr. Charles Brenner, and as a layperson I can’t seem to understand all the technical details. Can you eventually shed some light on this disagreement? Thanks. 6 GIAZEN Events GIAZEN Events 5 months ago Best podcast / YT! So glad this channel was created it really easy to follow and so much valuable information. X 2 Jessica Bennett Jessica Bennett 5 months ago Love these podcasts! Two questions. I see several pts with elevated B12, is this of concern or does it indicate anything? Also, is there a list of recommended targeted levels of each vitamin we should reach to have optimal levels not just ones in the “normal” range? Thank you! Eddie Hanson Eddie Hanson 5 months ago Thank you. This is life-changing viewing. Ritu Sharma Ritu Sharma 5 months ago I've been listening to you and am amazed at all research and trials that you have been conducting for the benefit of mankind. Sitting here in India I am able to get the information that I would never have access to. Thank you for all your talks. My question to you is, I have been doing intermittent fasting and loving it. I did it for a month with great results, high energy levels. However I was taking no supplements. I am again on intermittent fasting for the past one month. Two meals a day and I have just been diagnosed with a vit B deficiency. I have started on a vit B supplement. Do you have any suggestions on what I should do. Thanks. Looking forward to hearing from you. 2 Youtube Iscruel Youtube Iscruel 5 months ago Wow hes been taking athletic greens for years! Amazing he has forgotten to mention it in his publicized supplement stack until he was being paid to say he takes it. What a coincidence! 6 Patricia Soza LAc. Patricia Soza LAc. 5 months ago I just love this podcast. Thank you for sharing all this information! 5 TheBladeMasterOfLove TheBladeMasterOfLove 5 months ago (edited) Exceptionally episode as always. You really complement each other well! La Vita La Vita 5 months ago Thank you always ! Reassuring to know with great experts 2 Sandra Killalea Sandra Killalea 5 months ago This is an Excellent episode; they all are. Thank you for the part of you, you both, that is altruism. 2 MVC MVC 5 months ago I see that David Sinclair has posted a video and come directly to give it a like, even before I watch it.That is how good everything he does is. Thank you sir. 1 Explorers of the World Explorers of the World 5 months ago thank you for very valuable and useful knowledge, I would be interested in the topic of fertility in women, how to care for it and whether it can be kept Dottie polly Dottie polly 5 months ago Keep up the good work Mr Sinclair 👍👍👍👍👍👍 4 chickensandw1tch chickensandw1tch 2 weeks ago (edited) 0:50 ❤️💯😎 1:30 trippy! 3:00😍🙏🏻😎 9:00 😎🧠 14:10 lol savage times💀😂 18:00 3 longevity pathways 25:00 resveratrol🙌🏻 34:10 oleic acid and omega-3 42:00 metformin 54:00 sleep🙏🏻 Dr Christian Thoma Dr Christian Thoma 5 months ago Thank you David and Mathew for an excellent series. Apologies if this was corrected later in the podcast, I didn't want to forget posting this. There is a slight error earlier on - vitamin B12 refers to the cobalamins not to folic acid. B12 is found only in animal products and faecal matter contaminated vegetables. There is some synthesis by bacteria in the large bowel, and some evidence of absorption, although I'm not aware of this being quantified. Folic acid is the term for synthetic folate, which is distinct from naturally occurring folates. Folic acid is in an oxidised form and needs to be converted to be biologically active, whereas natural folates in food are in their oxidised form. Folate, sometimes referred to vitamin B9, but not frequently, is mostly found in plants, although liver, being the storage organ, is also a viable source. I look forward to listening to the rest of the podcast. evolve evolve 2 months ago (edited) Two more episodes! ;) Thanks! I will listen later on. Awesome. I'm kinda slow.. but find this stuff eventually. Could have been next year also, so yeah.. could have been worse maybe. ;) Keep it up! I love this podcast!! I could use some brain health tip also. Now i'm a put some shrimps on the ba... nah i'm gonna rest some. ;) No offense and that was not about your or others intelligence, i'm just racist.. No i'm not it was a joke i'm just tired. Peace out and thanks for sharing. You guys are smart for real! Australians seems to rock. 🙏 perkyzombie perkyzombie 5 months ago Thank-you so much for sharing all this research, for myself it has not fallen upon deft ears. I love rigorous science and all it's intricacies. God bless. TLH Peach TLH Peach 5 months ago Great episode! My question is what about melatonin…good or bad for sleep? 4 Pontus Olsson Pontus Olsson 5 months ago I will say this: David Sinclair is fairly sure about the things he speaks about, however he is not 100% certain, I did see some doubt in him. Essentially, what he has said so far might change to a big or small extent once time passes, and more research is needed. But the knowledge is still valuable, but may feature some unknown flaws and unintended sideffects. We should keep an open mind, but be aware of this as well. 10 Vincent ACK Vincent ACK 4 months ago I would love to hear david more explaining more without the hosts interruptions Brandon Brandon 3 months ago Thank you guys so much for this invaluable information. Crypto Quest Crypto Quest 5 months ago valuable information as always thank you for making this. 2 Quaran Tees Quaran Tees 5 months ago Fantastic episode again guys, thank you 😊 3 Mari Des Mari Des 1 month ago Watch out with B6! I live in the Netherlands where they tested different brands of multivitamins. Although it showed 100 % of the daily recommended dose some did contain much more causing numbness in the tooth and fingers. B12 can also be obtained from spirulina and seaweed you do not have to consume meat Ivermouth Pwr Ivermouth Pwr 5 months ago Interesting. I always heard there wasn't such a thing as having too high b12 levels 3 Anne williams Anne williams 2 months ago People like David Sinclair, Aubrey de Grey, Jason Fung, Liz Parrish makes me honestly believe that we can say goodbye to pathetic diseases once and for all. For the last few months, I've been taking one tablet each day of NMN-Vitruvin Health supplement. I'm astounded to discover that my metabolism now functions as well as it did when I was a younger. Other outcomes aren't nearly as visible yet, but I saw a significant boost in energy and concentration. I'm going to order another few rounds from their website. It took around just 3-4 days to see a difference. 😇 Carlo R. S. Carlo R. S. 5 months ago I'm always amused when experts say "talk to your doctor about it." The vast majority of Drs know very little about nutrition to start with. I asked my Dr if he could get a HOMA-IR test for me & he had zero clue as to what I was talking about. With info readily available on the net now, some patients are light years ahead of their Drs! 1 Kunal Singh Rathore Kunal Singh Rathore 5 months ago (edited) Let’s Go..As much as I am excited to hear each episode, it makes me countdown to the last couple of episodes left.😣 3 Articulate99 Articulate99 2 months ago Always informative, thank you. Jeannine Murphy Jeannine Murphy 2 months ago Thank you for your brilliant work! Universe Universe 5 months ago (edited) Hello Dr. Sinclair Thank you for sharing a cutting edge information with all of us. This is indeed a life changing data. Would you please give us your take on : Royall jelly, Bee Bread, Bee Polen and Honey in regards of longevity, reducing inflamation and the risk of aging related diseases ? It is well know that the Bee queen eat only Royall Jelly and the life span is 5 to 6 years while the normal ,workers live 30- 40 days maximum. It is also a common fact that many of the bee keepers, live long and healthy life due to their exposure to bee products+having the benefit their office to be the nature.:-) So if you can share with us what you know about the bee products and if they could help us in terms of longevity, preventint aging diseses, and reducing inflamation. Thank you. 13 Rolf Jacobson Rolf Jacobson 5 months ago Thank David. Your series has been incredible. Are you on Patreon? i will support your channel more 4 Majid Nabavi Majid Nabavi 1 month ago Hi Prof Sinclair, while I thank you for your great research and scientific work, I would like to draw your attention to one important aspect of your approach. By informing people about potential benefits of NMN and other molecules you are taking and not revealing the reliable brands, you are exposing people to numerous low grade or even dangerous products out there. This could potentially harm or seriously damage the health of innocent people who just want to be healthier. Why not reveal a couple or safe and reliable brands? SHYLA ANDREWS SHYLA ANDREWS 5 months ago Hi Dr. Sinclair been following all your videos incredible information thanks for the same can you throw light on sleep apnea how to tackle this health problem.. F NE F NE 5 months ago Could you guys please always make the distinction between the average population and an extreme athlete? There are some people who workout twice a day at high intensity, max-out their HR on a regular basis, are already at nearly keto levels of glucose, already take extreme cold plunges daily, etc. Should these people still consider things like Berberine, Resveratrol, NMN, etc? Or could these bring them to the other extreme of the spectrum? (similar to how an athlete could easily be sodium deficient while 99% of the population has too much of it. What is true for 99% of people is often the opposite for extreme athletes). Thanks! 1 Natalie Axl Natalie Axl 5 months ago Thank you, Dr, David 🙏 2 Jeff Nixon Comedy Jeff Nixon Comedy 5 months ago I know my brain is young because it still thinks farts are hilarious. 28 PlantBased AthleteRealtor PlantBased AthleteRealtor 1 month ago Excellent! I’m grateful for your podcasts 💫🙏🏻 да нет да нет 4 days ago (edited) I know that most B- vitamins come from meat. So where to get them from when i gonna switch to a Mediterranean diet? Do we take them in supplements as well? Or do we still eat some meat occasionally? Also, i would love to hear how vitamin daily dose norms gonna change when we gonna switch to this stress activation life. As i understood we definitely gonna need more of b3 and phosphorus and mb something else? would be great to hear new proportions for ppls who yet cant track their blood levels directly every day with these devices. 1 Omit Tapir Omit Tapir 2 months ago Great episode Dr Sinclair and Matt. Please start new podcasts pronto.! ☺ busysuperhuman - Sara Pugh busysuperhuman - Sara Pugh 5 months ago Thank you very enjoyable and useful as always Marian Blum Marian Blum 4 months ago David suggested taking "at least 1 gram EPA". My understanding is that DHA is pretty readily converted to EPA but not viceversa so I've assumed it was probably ok to get more DHA. Algae supplements are all higher in DHA so to get a gram EPA you'd have to get even more DHA (very pricey, too). A few minutes later David advises to take at least a gram of 'these fatty acids' daily. Is that in total or each? I realize this is not medical advice but I think the message could be clearer. BlackMartini BlackMartini 5 months ago Can you do a video refuting the claims that resveratrol doesn't work on sirtuins? There's been several new studies I would like to hear your take on those studies 10 M J O'neill M J O'neill 2 months ago Find your podcast so informative. Can you list the supplements that a plant-based eater would need to take. I do take B12 and D but wondered what else I need to take daniel sielski daniel sielski 4 months ago (edited) Hi David, want to thank you for what you are doing for humanity's answer to longevity and a healthy lifestyle. I am thinking about taking a NR supplement and wanted to know which particular ones you recommend? I was looking at the NAD+ supplement by a company called: TRU NIAGEN. Also im gonna start following the mediterranean and okinaowen diet. One more thing regarding wine: How much red wine (Malbec/Petite Syrah) shall i drink per day before the alcohol becomes a negative effect?? Moses Rabuka Moses Rabuka 4 months ago “The brain ages slower than the rest of the body, significantly slower. Your brain is biologically younger than you are” 1 Valart VALERIE HOPE BENNETT Valart VALERIE HOPE BENNETT 4 months ago thanks to DR SINCLAIR AND MATT FOR SUCH HEALING ADVANCED INFORMATION WHICH WE ALL NEED FOR SELF EDUCATION ON IMPROVING OUR HEALTH AND LIVES. White Ninja White Ninja 4 months ago For once, a decent host who asks decent questions. Well, THAT is a change. Excellent program and well-worth the time viewing. Sk0lzky Sk0lzky 5 months ago Resveratrol can also be found in red wine vinegar and balsamic vinegar so if you can't afford supplements and don't drink alcohol give it a try! Posca is a very refreshing drink, and surprisingly tasty once you get past the initial acidic hit (aroma more than anything, it's actually not very sour for some reason. Tastes like weird, fruity mead) 4 Cheryl R Leigh Cheryl R Leigh 5 months ago Timestamps swiped from David and Matt's amazing show notes in description box: Timestamps: 00:00:00 Introducing Episode Seven: Aging of the Brain 00:04:39 Thanking the Sponsors 00:07:38 Ex-differentiation as a Driver of Aging 00:09:22 The Brain Ages Slowly 00:14:17 Cognitive Function and Plasticity 00:17:44 Three Longevity Pathways: mTOR, AMPK, and Sirtuins 00:23:26 Plant-based Diets and B-vitamins 00:28:32 Homocysteine, Plaque, and Vasculature 00:32:35 Fatty Acids 00:35:48 Physical Activity 00:39:14 Metformin 00:46:02 NAD Boosters 00:50:33 Increasing Blood Flow 00:53:20 Sleep 00:58:02 Overall Message: Keep your Brain Healthy 00:58:50 Next Week’s Episode and the Future of Medicine 01:01:21 Options for Subscription for Support 8 zebragiraffe1 zebragiraffe1 5 months ago (edited) I work with many elderly people in their 80s and 90s, and most of them are not overweight, can still walk short distances and many use their smart phones to stream into their hearing aids or use the app to control the hearing aid volume and programs. They are inspiring. Paul Wolf Paul Wolf 5 months ago 🧠reversing brain aging and getting your lost memories back again. The Doctor is always way out there ahead of the science fiction writers. Have any of his products ever worked? 1 Lorie J Lorie J 5 months ago Love this topic! 1 Inconceivable1191 Inconceivable1191 1 month ago You gotta reach out to YouTube so they can recommend this video virally to spread this priceless information Sharyn the vegan Sharyn the vegan 5 months ago I put dried seaweed in my spice grinder and make it into a powder, then I transfer it to an empty spice shaker and literally put it on everything. Like salad, my avocado toast (which is not toast, it's a flattened air fried potato 😁) topped with homegrown sprouts 😋 I'm new to your channel, but I would love to see you interview Dr Dean Ornish on the topic of Alzheimer's. He's doing a study now that I think you and your listeners would be interested in. 3 Trädet Trädet 5 months ago Great as always except the voice delay, noticed something simular in earlier videos too. Minor inconvenience, thank you for sharing :) PlantBased AthleteRealtor PlantBased AthleteRealtor 4 weeks ago Thank you so much for a great podcast! Please make one about HLAB27 positive 💫🙏🏻 Deep Dusto Deep Dusto 4 months ago This series is the biggest contribution to humanity from ANY scientist that I have seen so far. It is the smart consumers that are activists and appreciate such knowledge and we have been ignored in past. We observe when scientists keep knowledge privy to themselves. I think genetics is precisely such a field. People that have their whole genome sequenced sit on massively precious data but are unable to explore it meaningfully since genetics know-how is kept privy to chosen few, and the market is filled with useless tools. I am hoping that season 2 can bring genetics and its "applications" such as WGS, various helpful toolsets that can be used to understand and explore ones pathways etc. Olga Willemsen Olga Willemsen 5 months ago I found fascinating the fact and the explanation for the brain aging slower than the rest of the body. Isn’t it the reason why when we age we keep feeling young inside??? Iggy Biggy Iggy Biggy 3 months ago So interested in knowing the updated Info on NMN and cancer. I’m a cancer survivor so this is of particular importance to me. So when I found this out I came off the NMN. But I had such great benefit from it soooo I miss it! What’s the bottom line? Windstone Press Windstone Press 5 months ago This was all great information, but when it comes to brain health and especially preventing dementia, the studies on fasting, ketogenic diets, and sauna are really important! 5 Brendan Fox Brendan Fox 5 months ago That was a brilliant podcast , David . So interesting . Keep up your good work , well done . Be Strong and Love Yourself Be Strong and Love Yourself 5 months ago I just got my first Inside Tracker Inner Age test results and I am 10 years younger than my chronological age! It made me so happy! 😁 I hope that if I follow Inside Tracker recommendations and advices given on this podcast I will be able to become even younger! 😊 Thank you for the information that you are sharing! 🙏🥰 Nicolás Guarín Nicolás Guarín 5 months ago This probably the only podcast that will give you ROT (return on time). Great knowledge. Maria Shchegoleva Maria Shchegoleva 5 months ago great episode! thanks 💛 Scias Scias 5 months ago In the next episode, could you talk about what kinds of sensors you'd want to see rolled out into next gen smart watches? I say smart watches specifically, because I believe that's the gateway to mainstream adoption. MrEtc31265 MrEtc31265 5 months ago I have started using a Far Infra Red sauna blanket that I believe is improving my blood circulation. Any thought on Astaxanthin as a supplement? Thanks. 3 T M T M 5 months ago I'm very fascinated to know what Dr. Sinclair is talking about, when he refers to chemical molecules, and genetic structure. For someone with a STEM background, but with only high school level biology knowledge, what are the fewest number of classes one would need to self learn the knowledge to know what Dr. Sinclair is talking about? Tobi Tobi 1 month ago Realy enjoied the episode. Can polyphasic sleep infuence aging? Or what are your thoughts on polyphasic sleep in tirm of aging? 1 Hassan Syed Hassan Syed 5 months ago Water intake also increase the blood flow and very effective for brain health Brad Stonestreet Brad Stonestreet 5 months ago Sorry to hear about your mind going Dave. I'm 51 and my mind is still as strong as it has ever been. I don't know what to tell you. Ethan Cowart Ethan Cowart 5 months ago i wanna hear david sinclair talk about the molecule 5 amino 1mq. that would be cool MrJamesdryable MrJamesdryable 5 months ago Nice of Matt to have David on the show again. 4 ren encar ren encar 2 months ago What i like in this interview is it is so organize and you can track back what you have missed.kuddos new follower Freeride Forever Freeride Forever 5 months ago Thanks for your work Dave. Isn't it insane that more people haven't gotten to work on our biggest prob? Our worst disease? Like why hasn't Elon started an anti-aging company? The way he misses milestone predictions he might wanna extend his life a good bit so he can actually see FSD & Mars happen. 😐 1 Tiernan McCarthy-Kenney Tiernan McCarthy-Kenney 5 months ago Great podcast, you two definitely need to stay together. You play off each other perfectly 4 Cappypyram saudpate Cappypyram saudpate 2 months ago I wonder if David could touch up on some mental health or behavioral topics if that would be of any relevancy. Not to be a an absolute downer but i come from a history of existential nihilism and so far, finding an ultimate purpose in life is what drives you out of this depression. Well as we extend ourselves, how can we stay happy or neutral for years, or even just sane? Twain Mom Twain Mom 5 months ago (edited) Matt is a good writer & communicator but, man…just looking at him…he doesn’t look like he walks the walk. Sinclair, on the other hand, is fit, you can tell he’s himself is implementing everything (intermittent fasting, nutrition, supplements, physical exercise) he advises people to do. The physical contrast between the two is glaring. Veronica Roman Veronica Roman 5 months ago Thank you David Sinclair!! Im curious on what kind of exercise & frequency impacts the brain and is most optimal for longetiviy (but also a functioning productive mind) I understand there is a difference in health vs performance but am excited for your research 😊 8 Michele M Michele M 5 months ago With sleep, not enough people are talking about sleep apnea and how damaging to the brain it is. So many people have it and don't know. I have it, and I don't fit the profile, because I'm skinny and female, so it took a while for me to get a proper diagnosis with a lab sleep study. Snoring, frequent waking, nightmares, heart racing, breathing difficulties can be signs during sleep. And sleepiness and brain fog during the day is also a sign. I have a fitness watch that tracks sleep stages and pulse oxygen. Sleep apnea makes my oxygen drop when I'm sleeping, keeps me out of deep sleep stages, and causes my heart rate and stress levels to go up during sleep. I now have a dental device that keeps my jaw forward and airway clear. 1 CindyBelle CindyBelle 5 months ago (edited) Lung diseases including COPD are supposedly irreversible, are in the top 4 of the deadliest diseases, but never seem to be included in any new health discoveries. Could lung diseases perhaps benefit or even be reversed using David's discoveries? I'm very much enjoying the podcasts but was hoping to hear lungs included. Mysteroo Mysteroo 5 months ago I've read that folic acid is something you actually want to avoid- whereas folate is what we need more of Lynn Nestor Lynn Nestor 5 months ago Brilliant content …yet again! Paris Outside My Front Door Paris Outside My Front Door 5 months ago Again, my question is do these interventions, which increase NAD, also increase production of already damaged, cancer-promoting mitochondria? You addressed this question in another video, but I wonder if you might go into more depth in the future. Dusty Carpenter Dusty Carpenter 5 months ago (edited) Question/invitation for conversation: I've had great success with improving my health on a carnivore diet and intermittent fasting. The talk about a plant-based diet here makes me nervous. I've been a vegetarian for a few years and even went vegan for a while, but I've never felt this good and seen so many improvements as I have on the current protocol. I'm 60. I no longer have all the bad (very bad) habits I acquired in the 60s and 70s. I work out a the gym a few times a week. I'm taking NMN and resveratrol, a natural sourced D3 (5000 IU) on occasion along with magnesium and potassium, krill oil, AKG, and am looking into metformin. So, my question is, am I sabotaging the potential longevity I'm hoping for on this diet? Thanks in advance! 7 marthie valentine marthie valentine 5 months ago Halo Dr Sinclair, Thanx for your podcasts. I am learning a lot. I do want to ask. Have you done some research on Chemo brain? The supplements you talk about are not recomended if you have cancer. 2 jack buaer jack buaer 5 months ago NAD boosters have not extended life in mice, at least in the most rigorous ITP trials. NMN made little or no improvement in human health in the first human efficacy trial according to Dr. Petter Attia. So are we being led down a rabbit hole? 2 KD Counseling KD Counseling 5 months ago Perfect timing thank you 😊 2 Lindy T Lindy T 5 months ago David, your podcast fans love Matt; just MUST keep him. The good natured ribbing between you two helps keep the science from getting boring. Learn More Learn More 5 months ago I am applying for Harvard postgraduate next year hopefully I will be able to meet David. 1 Creighton Freeman Creighton Freeman 5 months ago Omega-3 fatty acids are plant oils. Algae (sea weed) is the best source of them. The only reason fish have Omega-3s in them is because they eat algae or smaller fish that eat algae. You can skip the fish and go direct to the source. There are a few companies that sell algae derived omega-3. The Only draw back to them at the moment is that because the volume sales is less than fish oils, the price is currently higher. You are less likely to get bio-accumulated pollutants from the algae derived oils than from the fish though. Pollutants increase in concentration the higher up you go on the trophic level. 6 Patrick Furlong Patrick Furlong 5 months ago Growing body of evidence around the neuroprotective effects of ketogenic states and ketosis! Great option for mild cognitive impairment, early Alzheimer’s. Definitely missed that topic here. Jeff Willems Jeff Willems 5 months ago What about creatine as a supplement? Good to fight ageing when combined with exercise or bad as a signal that resources are plentiful? 1 Anna Abrante Anna Abrante 5 months ago So come to find that Niagen causes some really bad headaches. I wish he had told us that. 1 Devon K Devon K 4 months ago Matt is an awesome cohost he is a keeper! Where Nerdy is Cool! Where Nerdy is Cool! 5 months ago I'd be really curious his thoughts on resveratrol pterostilbene 2 Biplob Paul Biplob Paul 5 months ago One thing is to say, olive oil is a must. 4 In Hoc Signo Vinces In Hoc Signo Vinces 5 months ago I wonder if Dr Sinclair has any thoughts on Piracetam, the original nootropic. Studies have found it to protect mitochondria against different conditions associated with oxidative stress, including aging. 2 Willis The Wise Willis The Wise 5 months ago What are your thoughts on hyperbaric oxygen chambers in lengthening telemeres? I've read it causes oxidative stress on the body similar to fasting. 1 snow white snow white 4 months ago (edited) 52:37 I think he meant the Hypothalamus! Thank you so much for this. ROB KING ROB KING 5 months ago Dr Sinclair, please address the controversy regarding GSK dropping the company you sold to them and the discrepancy of resveratrol findings. Thank you! 1 Neil Quinn Neil Quinn 5 months ago David, how much do we know about how much the MTHFR mutations affect all of the methylation pathways and how bad they are? For example this SNP: rs1801133(T;T) - homozygous for C677T of MTHFR = 10-20% efficiency in processing folic acid = high homocysteine, low B12 and folate levels. Only 10-20% efficiency seems scary, and nearly 9% of caucasions have this variant. (higher in others). Are there other better biomarkers you would measure around b12/folate? Margaret Attiyeh Margaret Attiyeh 5 months ago 33:39...People should have a ratio of EPA to DHA of 1.6 but women should have a ratio of 1.3...Now, I know that Dr Sinclair knows that women are people and that people with limited brain function are NOT useless...I know he is a scientist in an exclusive university doing very high level work and not a social activist...But precision is important in science and it is important in communicating. And he is sitting across from a writer and has editors. There are also over 120,000 subscribers...They can't all be white men. Do better. 3 ILUMiNATiVE ILUMiNATiVE 5 months ago Genius levels of knowledge! Sky Rider Sky Rider 5 months ago 😁😆So funny with the opening -- "So far" 0:46 Thanks guys. Keep up the great work! 1 Sharyn the vegan Sharyn the vegan 5 months ago I don't think we're living longer, I think we're just dying slower... 1 Arham Abbasi Arham Abbasi 5 months ago Would love to have your input about corticobasal degeneration. My aunt is suffering badly. 1 chon rodriguez chon rodriguez 4 months ago I recently stopped drinking coffee just to see how my mind and body would react first my head hurt so bad the next day the day after aswell. I feel stronger during my workouts as I was always taking coffee for the last 6 months to hit the gym and now I don't even feel like I need it . it was all in my mind thinking that coffee would be the only way to get gains. nothing but water and ashwagonda and some good meals low carb high protein. I feel really good in class I can concentrate a whole.lot more !!! matzefritz matzefritz 5 months ago It is a myth that the mediterranian diet is just plant based. They eat lots of plants and spices ans so do I. BUT They DO eat meat on a regular basis. It seems to me that David Sinclair is part of a vegetarian cult trying to do science. In this case they communicate ideology. Otherwise I respect Sinclair and I think that most of his work has a sound basis. 3 Isabella WolfsKeil Isabella WolfsKeil 5 months ago Can you create a downloadable pdf which summarizes the protocol you suggest or at least re-cap what actions we can take at the end of each episode? youre* mom youre* mom 5 months ago So how do we offset the detriments of a missed nights sleep? How do we recover most efficiently M M 5 months ago What Sinclair says about people on plant-based diets requiring ALA instead of EPA/DHA is totally false. The conversion rate is terrible. Algae derived EPA/DHA supplements are readily available, especially online (I think I’ve seen it in Flintstone vitamins), and a perfect alternative to fish oil. Algae is where the fish get it from 2 sherlock1 holmes sherlock1 holmes 3 months ago The Cappuccio study showed a 30% increased risk of dying in people who OVERslept (ie more than 9 hours), for the undersleepers (ie <6hrs) it was 12%. Melissa Todd Melissa Todd 5 months ago How important is eating before you take supplements. I notice when I take a lot at once I get very nauseous. Love you guys! VictorSneller VictorSneller 5 months ago Hey, he’s doing a good job man! Leave him alone! 6 SomeAssemblyRequired SomeAssemblyRequired 5 months ago I hope this podcast becomes a perfect example of the cart leading the horse. If people are primed to expect research and results, I think they're more likely to advocate for it. All of these happy futures can only be achieved if we fund them. And funding is driven by interest. PrimTake Tv PrimTake Tv 2 days ago Health and social care for these conditions require multisectoral and interdisciplinary collaborations with a holistic person-centered approach focused on promotion, prevention, treatment, care and rehabilitation over the lifespan and the active engagement of persons with lived experience, their families and carers. Mar z. Mar z. 5 months ago Could you talk time perception in the human body and how to slow it down Péťa Péťa 5 months ago Blessed day with new upload. Thank you! Kantraj K Kantraj K 5 months ago Thank you so much ❤️🙏 2 Bro Tein Bro Tein 5 months ago There are a few scientists currently dragging your scientific credibility through the mud because of your unyielding position on the life extending benefits of resveratrol, despite the most recent papers showing it not to be case. Will you be responding to those accusations and help dissect all the recent data? 8 Bart Angel Bart Angel 5 months ago I read that anthocyanins help with neurogenesis is that true? and although some foods like blueberries bilberries and purple corn have lots of them they are low in bioavailability. what foods should I eat that would help with bioavailability of anthocyanins? 1 SK. N. SK. N. 4 months ago (edited) No, no, a mediterranean diet is not a hardship experience for the body (on the contrary, it’s significantly better than standard american diet), but intermittent fasting is a hardship, in a good way. Sinclair was mixing these two up. chris tinley chris tinley 4 months ago Ok… im still waiting for the next season to start.. will there be another? I check ev monday… please… make…. More… videos lol!!!!! Tom Corriher Tom Corriher 4 months ago David, has your lab done this... After you reset the epigenetic clock has anyone checked the telomere length before and after. The reason I am asking is if telomeres are not lengenthing then the cell could unravel in later life. Defeating the reset. Gasman super Gasman super 5 months ago I am taking NMN and resveratrol 1mg each every other day and i have a question if anyone can help here. Could taking NMN on a daily bases, reduce the capability of our body to produce itself by exercize and fastings and ice bath? As i know, body is a lazy machine and if knows we take NMN orally, it won't want to make the effort producing it. So i am worried that, once i start taking nmn orally i will be hooked for life, since my body will lose the will to produce it naturally. 1 Vee Hope Vee Hope 5 months ago Red wine red wine yeah yeah yeah, what about the alcohol in red wine? Studies now show there is no safe amount of alcohol. Talk about that. 5 Greg Ewing Greg Ewing 5 months ago So i am in NZ. Getting these supplements are bloody expensive, if i can even find them. Also metformin is prescription only, its hard to get doctors on your side here. (struggling to get them to just give me results from my last blood test! ). So kinda stuck with the "no supplement" way. But anyone else here have hints for NZ, i love to hear em. Yann Lang Yann Lang 2 months ago I love Professor Sinclair and I admire him, but instead of speaking for nothing he better get us his rejuvenating solution. Make Money Media Make Money Media 5 months ago Thank you so much I love you guys!!!! 1 Raimonds Urtāns Raimonds Urtāns 5 months ago My homocysteine levels been high since I decided to test it. I got it once down to normal, only once. All I have found is that it is affected by B12 and folic acid. Can you help me to lower it? Lester Lester 5 months ago (edited) Resveratrol from red wine - you mentioned in a previous podcast that one glass of red wine per day has such small amounts of this that it makes it inconsequential, and that you would need to drink thousands of glasses of red wine to have any real meaningful result perhaps over the course of years. Is the benefit higher than the liver damage, or potential psychological addiction to alcohol? Wouldn't taking a supplement or perhaps finding a less damaging source of resveratrol be more beneficial? Succesful Person Succesful Person 5 months ago I was wondering why Dr. Walter Longo mentions breakfast as very important and David Sinclair does not. That eating breakfast has great benefits in the long run. What research says that? 3 whatUneverknew whatUneverknew 4 months ago Rofl. That executive function joke slayed me! 🤣🤣🤣 Sachin Singh Sachin Singh 5 months ago Hi Professor, How the excessive consumption of the high sugar content food effect brain function and how sirtuins play the role in pschatric disorders induced due to the high sugar consumption. 2. What kind of the epigenetic change induced in the brain due to prolong high sugar consumption Ramen Tabetai Ramen Tabetai 5 months ago Montelukast decreases brain inflammation btw. Worth checking it out. Though rarely it can cause depression. HOMBRE X HOMBRE X 5 months ago Thank you both👏👏👏 Robert Fox Robert Fox 5 months ago Thank you! Walk & Relax Walk & Relax 5 months ago David Sinclair looks like he is 25 and 45 years old at the same time... but... he is 52! 4 Yan Shen Yan Shen 4 months ago You mentioned elsewhere that you were working on restoring eyesight in mice and then maybe do human trials ... would that method work on Parkinsons to make more dopamine producing cells in the brain? if so I am very interested about that ... Yair Horesh Yair Horesh 5 months ago You forgot Lythium orotate. It hugely increases BDNF GEMA Gemproimage GEMA Gemproimage 5 months ago Doctor, I have a question could you explain if possible what happened in the case of Shauna Rae or similar cases, Is it possible to see something similar in someone who is 20 years old? hope you see this question . Thank you for your work. Donna Oliver Donna Oliver 3 weeks ago (edited) I am curious; would there be any rebound effect if the supplementation were stopped? Brad Stonestreet Brad Stonestreet 5 months ago I eat a ketogenic style and my cognitive function is incredible. I am 51, muscular and active. Explain that if you believe supplementation is necessary. Margaret Attiyeh Margaret Attiyeh 5 months ago People without well functioning brains are actually not useless. 3 Starving Samoan Starving Samoan 5 months ago Love Matts hats and overall sense of fashion. 1 Rose Mary Rose Mary 5 months ago Once I had omega3 for too long, when undergoing a surgery I almost bled to death. swenic swenic 5 months ago Any advice for someone like me who has 'executive' distractions? I think I need the tldr straight and concise. Plis. Martín Escarrá Martín Escarrá 3 months ago If the CD ROM is the genome and the CD reader the epigenome, then, in that analogy, aging should be caused by the reader's laser losing gain instead of CD scratches, right? rebaked rebaked 5 months ago Right. There is no point in reaching 100yo if you can't remember the faces of loved ones 1 Scott Summerill Scott Summerill 5 months ago Seriously suggest that Matthew read the ingredients on his seaweed. Think you'll find added blue and/or green dye. It's why I stopped eating seaweed. So again, you mentioned red wine but a) it does not contain a significant amount of resveratrol, b) any amount of alcohol hurts the brain and liver, and c) I thought you stopped drinking. Did you or not? Thanks! Relaxo Relaxo 2 months ago I cannot profit from the Level offer as I live in Australia 😞, thanks for the content Audrey Hurley Audrey Hurley 5 months ago Love podcasts! But why do you keep bringing up Metformin- it’s not readily available has to be prescribed by doctor. Most doctors, mine included won’t prescribe if there’s no diabetes or pre diabetes. 1 Andreas Stuermer Andreas Stuermer 5 months ago (edited) Is there a commercial service that you can send cells to, so they measure the DNA methylation clock using the Horvath algorithm? 1 Daisy Huang Daisy Huang 2 months ago Thank you for your sharing 😊 Erika Erika 5 months ago David, there is a dire need for raising the IQ in millions of people. 😁 Katerina Katerina 4 months ago Great talk! m saz m saz 4 months ago I really like to hear about infertility and premature menopause. susy may susy may 5 months ago Great timestamps! Claudia Claudia Claudia Claudia 5 months ago (edited) What happens if someone taking Metformin without having diabetes stops taking it? Do things function as before or they need it to take it for the rest of their life to be ok? Thanks. Theresa Tilbury Theresa Tilbury 5 months ago Hi, with regards to bloods I have heard you speak about 7 main biomarkers to check (on the Andrew Huberman podcast), but please would you kindly list what these biomarkers are. Many thanks. Matthew Green Matthew Green 5 months ago Is there an upper limit on how much Olive Oil you could consume daily? MrEtc31265 MrEtc31265 5 months ago In this series, have you spoke in detail about woman's health? 1 SK. N. SK. N. 4 months ago Best recommendations for brain health are Drs. Sherzai (both neurologists). Am shocked that too much of what Sinclair says is either incomplete or false. 1 Joseph D'Alecy Joseph D'Alecy 5 months ago I think it would add a lot of value to include pictures of what you're both talking about. Crypto Kids Crypto Kids 5 months ago Thanks for your work and for sharing with us! You da man 2 Влад Третьяков Влад Третьяков 5 months ago Every diet compared to standard American will show benefits. Mediterranean is the most studied, but not sure the best. 1 Tilveran Tilveran 3 months ago How well does berberine stack up against metformin? I ask because berberine doesn't require a doctor's prescription. 1 Mark Mark 5 months ago Thank you again <3 Spoudaois Spoudaois 5 months ago (edited) Plant based diets are the healthiest because humans and other primates evolved to eat that way. Humans in particular are starch eaters. We have the highest amylase in our saliva of the primates. 2 Yes Sir Yes Sir 5 months ago Which would you recommend: NMN or NR+Pterostilbene? Poonam Prabhat Poonam Prabhat 4 months ago I have a 16 year old daughter with low functioning Autism and I’m hoping and praying some day you will come out with something which can help me with her and make life better for her. Kindly help me by answering if I can introduce some omega 3-6-9 in her diet along with other things. I wil really appreciate if you could help me @drdavidsinclair 🙏 Summer Summer 5 months ago So my question is "taking 1 gram of B3 (Niacin) will work equally??" narcisa avataji narcisa avataji 4 months ago Hello! Do you have any research on autism? Thank you in advance. John F John F 5 months ago (edited) Look up the controversy regarding David Sinclair's core scientific research. It is not reproduced outside of yeast. And he is not addressing that honestly. Instead blocking good scientists who point out that some of the core things he talks about have since been abandoned by most. Vospi Vospi 5 months ago 24:25 Folic acid is not b12, it's b9. It's not even b9, it's a precursor to it. I'm sure you just misspoke. Also, Pacman doesn't jump, not usually. 1 Kimberly F Kimberly F 5 months ago Ok, let me get this. We should eat a mostly vegetarian diet, but then that makes us deficient in nutrients that both age us and can only be found in red meat. How on earth does this make sense? 1 B B B B 5 months ago Getting metformin is almost impossible in the uk and maybe also in other countries its very hard, or impossible - unless you have diabetics or are a famous person who seem to be able to bypass the doctor training system. Is there an alternative ? jackjack jackjack 3 months ago The duo is so funny together. Dr.Sinclair has such dry wit =)) haha. Victor Louie Victor Louie 5 months ago Where can I find enamen supplements for sleep health. Great show! FOR8YESHUA FOR8YESHUA 5 months ago A Vegan Mediterranean+ diet is to consume grapes or fresh Grape Juice that include the skin of grapes (avoid wine to avoid the alcohol to avoid increasing the homocysteine levels), and olive as a whole food instead of the oil (missing nutritional benefits of whole olives). Ian Baber Ian Baber 5 months ago "My brain? That's my second favorite organ." Woody Allen. Jeff Little Jeff Little 5 months ago I think you are making a big mistake with respect to folic acid. Our bodies use Folate, not folic acid. We used to think that folic acid and folate were interchangeable, but in another instance of "it turns out that we are not rats", folic acid is converted to useful folate far slower than we previously thought and large quantities of folic acid are bad for the liver. If you supplement, make sure you are getting folate and not folic acid. This is another argument for making sure you have plenty of greens. saul sheehy saul sheehy 4 months ago Will there be another updated book anytime? Mary Mc Mary Mc 3 months ago Not so. It’s not so bad to lose your mind as long you are happy, or at least with a semblance of happiness, but most people I’ve seen with dementia are querulous, complaining, not happy. Perhaps a cheer-up drug? I read recently that laughing gas has used effectively (don’t laugh). Cassian YHVH Cassian YHVH 4 weeks ago In these podcasts are there any references to metformin as a longevity drug? Douglas Abramski Douglas Abramski 5 months ago Superb! S Nelson S Nelson 5 months ago A futuristic movie made in 2005 called 'The Island' with Ewan McGregor & Scarlett Johanssen had a scene where Ewan (with the single prick of his finger each morning) had his blood analyzed and was told what to eat that day. Island Tracker seems something like that, but not as simple. :) Ilya Bykov Ilya Bykov 4 months ago (edited) "Yeah I'm 52" - Looks better than me at 30...he's not even gray? I've never seen anyone to look this young at his age... Kate Alvo Kate Alvo 5 months ago Hi! Is it possible to know what the future episodes will be about? Will you please do one on menopause? Thank you :) Anna Abrante Anna Abrante 5 months ago I inherited at least 8 longevity genes (with the effective allele). I'm 58 and have ZERO medical issues, with one exception... High LDL. It won't drop from the 150s no matter what I do. And the one time it moved down a little my memory got frighteningly bad. It corrected with milk and eggs, but I digress... I can't help but feel it's protective, so I refuse statins. My grandfather on dad's side lived to 99, my mother to 97 (covid killed her, she was still strong prior), her sister to 100... I intend to break 110. My daughter has homozygous longevity genes (the G allele where it matters most, twice) With luck she could break 120. These genes really do work and it's very clear to me as I get older. No one believes I'm 58. I do not look it. jennifer Zengineer jennifer Zengineer 5 months ago Folic acid doesn’t have the methyl group and is not the same as folate, the natural form, which is methylated. TheBody360 TheBody360 5 months ago If you go to your GP in the UK and ask to check homocysteine they just look at you aghast. Such an important marker to check and monitor closely.....I hope the budget for preventative healthcare changes in the UK....and very soon! Cindy Cindy 5 months ago Could you list all the supplements you take please? Hayley Green Hayley Green 5 months ago I would truly enjoy this podcast series more if Mathew was not apart of it. I find that he often interrupts David and that he directs the conversation away from what David is wanting to talk about. The original conversation between Sinclair and Huberman was much more informative and enjoyable. I understand that Dr Sinclair feels like he needs a co-host. I highly recommend that he continue solo in the future or interview other scientist in his field. Thank you! Patrick Day Patrick Day 5 days ago (edited) Sorry David but that beginning explanation of brain cell malfunction acting like a liver cell wasn't the best alzheimer's is a prion disease misfolded protein buildup coupled with decreased blood flow and other miscellaneous toxin build ups which I'm sure you'll discuss since I'm at the beginning 1 RealFoodRevolution RealFoodRevolution 5 months ago I heard that MCT oil is amazing for the brain!! Min Min Min Min 5 months ago (edited) David needs co host, without them, he sounds like a pastor on Sunday mass 😋 ann ann 5 months ago When you sleep for around 7 hours , but you sleep late like 2 or 3 am but wake up late like 9am , is this alright? jennifer Zengineer jennifer Zengineer 5 months ago “Red wine has very little resveretrol and it’s not worth drinking it if that’s what you’re trying to get” -DS …. “One good thing from the Mediterranean diet is red wine, because it has resveretrol” -DS 1 bob bobsen bob bobsen 5 months ago When you talk about how protein from meats are bad. Would you recommend protein from whey instead, or is it the same case? 1 disease /health /diets disease /health /diets 5 months ago Thanks!! 1 amaury_ amaury_ 5 months ago So, a mostly vegan version of the keto diet is a brain win? 1 Pespsi Jackson ● Pespsi Jackson ● 5 months ago plant based diet and 17 hour intermitent fasting daily and curcumin daily 2 Joe Tart Joe Tart 5 months ago From Resveratrol Wikipedia... "Although commonly used as a dietary supplement and studied in laboratory models of human diseases,[10] there is no high-quality evidence that resveratrol improves lifespan or has a substantial effect on any human disease.[11][12][13]" So? 2 NSA NSA NSA NSA 3 months ago Could someone share a link to a photo that they described at 32:25? I didn’t quite understood how it should look like snow white snow white 4 months ago I just bought a bunch of Resveratrol. But I don’t really know what to think after watching Dr. Brad Stanfield’s videos. I wish you would address them. european descent123 european descent123 5 months ago Chronologically but he said if there was a way to be younger then He would love to have that. Chris Carson (Old And In The Way) Chris Carson (Old And In The Way) 5 months ago Important advice from a 75 year old. Avoid this kind of garbage especially. Get out the door and up the mountain, and in my case, play video games. I have been doing the latter for a long time, and now its how much cheese I can come up with for any given situation. Bows to Uncle Sheo. ;) LittleOne3179 LittleOne3179 5 months ago Is the dosing of NMN related at all to bodyweight? For example if you were 105 pounds do you still need 1 g? Denis Edel Denis Edel 5 months ago Is metphormin safe for gut health? youre* mom youre* mom 5 months ago Arent PUFA toxic? Burning your pufa fat stores leads to alot of oxidative stress, harmful to your mitochondria. Something like that. Or Kurlander Or Kurlander 4 months ago Hi David, Any recommendations for inside tracker but in the UK? Thomas F. Thomas F. 5 months ago I'm taking 1 gram of MNM per day. Is it better to take in two doses (500 mg each) or once a day better? LB LB 5 months ago Christian Slater could play Dr. Sinclair in the movie about longevity Subira Dukes Subira Dukes 5 months ago So how much is sleep is optimal? I don't think I heard that in the sleep portion. Is it really 7-8 hours, or as I've heard 5-7 hours? Parsell Art Parsell Art 5 months ago Do you know what causes "brain fog" It is a pain to deal with. I am 79, but I also have younger friends in their 40's that suffer from it. I have been all over internet and to no avail. It does not seem that they have nailed that down or maybe they don't think it is serious enough to address. What do you think and know about it? Thanks Motivation Seeker Motivation Seeker 5 months ago These guys are the best Pedro Rodriguez Pedro Rodriguez 5 months ago I would like to hear David talking about the studies that say that resveratrol is not doing what David says in the body just works in co trolled environment in petri dish was kind of disappointing to hear that resveratrol is not good for what David says L'amour Alice L'amour Alice 4 months ago May I know what is the relation of NMN & AMPK? Tim Hag Tim Hag 5 months ago Seaweeds are actually the primary producers of EPA and DHA! Little fish do eat these and bigger fish eat little fish- this is why some of them are rich in these fats. Fish do not produce Omega 3! 1 Big Lenny Big Lenny 5 months ago Like listening to an add or billboard. Keep it real Life Master Life Master 5 months ago randomly 2nd one here! i'm here, listening and teaching others at same time about trading. Love your show always! :) 1 Sonora Suzie Sonora Suzie 3 weeks ago Vegans can get EPA and DHA from algae oil. Also, B12 is not folic acid or folate. B9 is folate. Thanks! Love the series! Dominik D Dominik D 5 months ago Something very worrying today. I've seen Dr. Brad Stanfield's video on YouTube and he says that resveratrol doesn't work. I don't know what to think anymore... please respond to his video and other people's claims about no real clinical trials about all this. 1 Faye Parker Faye Parker 5 months ago So does methylcobalamin increase methylation? Is that what's being said and what about the synthetic form of B-12-cyanocobalamin. Can that increase methylation as well? Bea Vizcarra Bea Vizcarra 5 months ago (edited) And God and Evolution said, “Sinclair we are done doing our work ensuring that human lives continue in the world. Please take over” 😂😂😂😂🤣 Listen, I’m happy to hear and take advice from this guy but let’s not forget we made this far without him. BTW not shaming him for it but also because I am scientist I have to say he has Botox all over his face. His hair it’s what impressive yet not sure if he colors it too 😉 But yes I am currently testing with resveratol and NMN as well as bunch of other supplements but remember people everyone is bias RM77 RM77 5 months ago I think Sinclair confused dha and epa no? Dha is the o3 more important for brain health at least as espoused by most medical professionals Danijela Dani Ivanovic McGillicuddy Danijela Dani Ivanovic McGillicuddy 5 months ago Great ideas, but so not true about vegan: vegetarian diet: Mediterranean diet is full of fish and Meat! I know- I lived there😉Anyhow, I love the some of informations 👏 1 Guy Waddington Guy Waddington 5 months ago Huntingtons disease, do you think NMN+resvertrol could help? @davidsinclair Al-Shaif Hirboush Al-Shaif Hirboush 5 months ago Trying to rectify the differences in opinion between Dr Sinclair and Dr Gabrielle Lyons with respect to the best protein sources. Incredibly frustrating when several credentialed and respected experts disagree on fundamentals D Behr D Behr 4 months ago 27.22 Folic acid is not the same as Vit b12. Folic acid is vitamin B9. V. Hansen V. Hansen 5 months ago What about meditation and breathing techniques? To lower your adrenaline and cortisol levels Nick Mitchell Nick Mitchell 4 months ago Please please please, can you offer some clues as to which NMN producers are better? There are so many to choose from and rumours of many brands being dodgy Dr Gregory House Dr Gregory House 5 months ago Should I start taking senolytics in my 20s? Chris Corey Chris Corey 5 months ago where do you get NMN powder in bulk that is high quality? someone someone 5 months ago Thank you! Greg Rodgers Greg Rodgers 5 months ago I know specifying brands for NMN is sticky, especially if they aren't a sponsor, but wish I had some guidance from a pro. Amazon is plagued with fake or impure supplement products. Toby Tobykins Toby Tobykins 5 months ago I love this, but your sidekick interrupts you SO much! Dr. Sinclair it is frustrating that you’re frequently unable to finish your thoughts. Xiaoyu Tang Xiaoyu Tang 5 months ago 27:24 Folic acid is absolutely not Vitamin B12 (Cyanocobalamin). Patrick Hourigan Patrick Hourigan 5 months ago Another beauty, lads! Leona Owen Leona Owen 5 months ago Ok her we go I had cataract surgery then dr lasered eye for blurred vision another dr found jel had come out from under the lense sent for eye surgery this dr REALLY messed my eye up. He did not get all the jel and I now have a oversized odd shaped pupil. He refuses to do anything and so far now other dr will do anything. My eye aches and I get headaches if in bright sun have to wear sunglasses outside. Richard Lee Richard Lee 5 months ago David, do you color your hair? I ask because you are 52, obviously quite healthy but even so, it is rare not to have a gray hair on your head at your age. Paprika Veg Paprika Veg 5 months ago Are there studies on the topic of converting AlAs into epas and dhas? european descent123 european descent123 5 months ago I’ll give you 15 years to solve the problem cuz 20 years is kinda pushing it. Yaboy Lindus Yaboy Lindus 5 months ago How does a person get fatty acids when all the Salmon (best source) at the grocery store is farmed salmon that is full of toxins and poison.I dont feel like eating half a kilo of Walnuts every day. Any recommendations? I bought omega 3 supplement pills but im not sure they are enough. Laurin Hamilton Laurin Hamilton 5 months ago Do you think that metformin also might benefit things like Parkinsons? Un-person Un-person 5 months ago Trick the body into thinking the food supply sucks? Or the food supply actually sucks, and the body is essentially fasted? Влад Третьяков Влад Третьяков 5 months ago On the one hand lack of vitamins B leads to accelerated aging and heart disease, on the other hand, David admits that plant-based diets in most cases will result in vitamins B deficiency. So what's the point to say that it's good for longevity if it's not? 1 review feedback review feedback 5 months ago What about high does of vitamin c for exssive stress? Sharon W Sharon W 5 months ago 5-HTP at night with Magnesium and Niacin really helps mood and sleep. I am 65 and was not sleeping well at all before. Jacky Wang Jacky Wang 5 months ago Is there any way for people who stay up late for a long time to make up for the damage to the brain? (Already improving their work and rest) (Google translate) Pespsi Jackson ● Pespsi Jackson ● 5 months ago curcumin activates sirt1 and ampk pathway and inhibits mtor 1 Angel Face Angel Face 5 months ago The Mediterranean a diet has well and truly been debunked in many research papers. So has plant based diet. If by definition a plant based diet deprives you of one of the most important brain health vitamins B 12 then this whole theory is called into question. Bioavailability of nutrients in plants is very low plus they are laced with anti nutrients. Then there are pesticides, GMO, poor soil quality, preservatives to prolong their shelf life etc. If the nutrients are not in the soil, the plant simply can’t make it. Georgia Ede Harvard psychiatrist speaks about the significant benefits of carnivore diet on mental and brain health. Sally k Norton is world expert on oxylates- the very damaging anti nutrient in plants like spinach. Also lectins. Gluten. Basically plants are designed to repel animals eating them as they cannot run away. Nothing in the world compared to the nutrition found in beef liver. See Sean Baker orthopedic surgeon on success of animal based diet. Leona Owen Leona Owen 5 months ago What can be done for bone health. just diagnosed with scoleosis and degenerative throsisic spine? Christina Christina 5 months ago Why choose a vegan diet to live longer when deficiencies make you sick and live shorter? In meat and fat from animals, you find all the B vitamins and oleic acid you need. I think it is nice of you to share your knowledge, yes, but there is NO EVIDENCE that any human has survived long term on a purely vegan diet, let alone made humans live longer. Theresa Excell Theresa Excell 5 months ago i can not for the life of me , convince my doctor to write a prescription for metformin ;( Darwini Darwini 5 months ago David Sinclair - please respond to Dr. Brad Stanfield. Science is about constantly evolving data. If resveratrol is as valuable as a phytoalexin as you make it out to be, surely there should be no reason not to have a healthy discussion with another antiageing researcher right? I love your work and everything you stand for, but I'm afraid his constant berating is tarnishing your reputation the longer you let it go on. Either way great episode as always. 1 Jordan Bowey Jordan Bowey 5 months ago As a kickboxer I'm terrified to watch this Judy Fasola Judy Fasola 5 months ago Dr.would Nystatin and Dyflucan.....be ok to take with your anti-aging Protacal ...which I'm on...... also will your protacal help with thinning hair ... 72 years young lady ❤️ sahil sharma sahil sharma 5 months ago Devraha baba lived for 250 years. Nangta baba lived for 300+years. Tatwale Baba stopped ageing at the age of 33 and remained same physically till he died 90. They were the masters of stopping old age. One more Prince of patiala who died when he was 180. Topdog525 Topdog525 5 months ago These r great! roc roc 4 months ago folic acid is b9 not b12, b12 is cobalamin SwimmingBird SwimmingBird 2 months ago I would get the Sinclair anti-aging fart perfume Ciarog Ciarog 5 months ago If you can check brain age for $1 in your lab, if and when you offer this to the public, how much will you charge us? european descent123 european descent123 5 months ago My father said he’s got 20 years in him can anything happen in 20 years??? gabrielbotero1 gabrielbotero1 5 months ago love it!!! take a look about olive leaf (Tea or extract) ....... better than olive oi it self!!!!!!!. Jeana Pillion Jeana Pillion 2 months ago How do you get Metformin without a prescription? Sophie M Sophie M 4 months ago what brand of NMN do you recommend? Fuj Chi Fuj Chi 5 months ago An Anti-Aging Pill? Think Twice by Gretchen Reynolds, NYT, June 19, 2019. Is there still controversy regarding exercise and metformin use by people over 65? Andrea Zalewski Andrea Zalewski 3 months ago Where can I purchase NMN in Australia? Jen Pal Jen Pal 1 month ago Any recommendations on which NMN brand is best? Dorota Brown Dorota Brown 5 months ago ❤️❤️❤️👏👏👏superb info😘😘😘 Brian Starr Brian Starr 5 months ago Let’s go!!!! Michael Michael 5 months ago (edited) Thoughts on cerebrolysin for brain health. Sophia Sonen Sophia Sonen 4 months ago Please talk about Astaxanthin and what it is and does. Sofian Chaybouti Sofian Chaybouti 5 months ago The discussion about alzheimer’s reminds me the planet of the apes: the origins RandomPower RandomPower 5 months ago I feel like David nowadays talks outside his core expertise. There is very little new information and when there is, it does not seem to be true. Some clear mistakes, like folic acid is not b12... Antonia L Antonia L 5 months ago What about physically active people taking metformin? Isn't there an adverse effect? haku4207 haku4207 5 months ago it can be dangerous to be in protein deficit gary robertson gary robertson 5 months ago 💪🏼💪🏼💪🏼 👍. Faye Parker Faye Parker 5 months ago I may be wrong but did he say that B-12 is folic acid or folate? I thought B-12 is cobalamin. Evolving X Evolving X 4 months ago folic acid is b9 not b12 1 Greg Rodgers Greg Rodgers 4 months ago Are they coming back or was that it for the podcast? SwimmingBird SwimmingBird 2 months ago Sinclair will have smooth glutes for Life ❤️هموطنان به جمع تظاهرکنندگان صنفی بپیوندیم ❤️ ❤️هموطنان به جمع تظاهرکنندگان صنفی بپیوندیم ❤️ 4 months ago 🙏😍❤️ Bjorn Welboren Bjorn Welboren 2 months ago Mhm Idk, it feels so much to take Complex Vitamin B supplements everyday and u never know when u have enough, tests are expensive and not accessible. Ankush Sharma Ankush Sharma 5 months ago once more keep going Victoria g0y ChristIsKing Victoria g0y ChristIsKing 5 months ago yayyyyyyyy you started your own channel!!!! 1 Andrew Ross Andrew Ross 5 months ago Thoughts on intranasal NAD+? Kenneth Tang Kenneth Tang 5 months ago What about taking creatine monohydrate for brain health? emilee _ emilee _ 5 months ago omega 3 are a lot in Grass fed Products, no one say that, example Beef or Milch Grass fed. Or good eggs also. No plants Products are enough.... we are not born with suplemments..... so when Plant base Diet has not enought of so many nutrients, is it not good for us??? Thats logic for me..... Biju’s Version Biju’s Version 5 months ago (edited) Was counting down 😀 european descent123 european descent123 5 months ago He’s 71 he said he could live to 90 Sille Juul Kjaerbo Sille Juul Kjaerbo 5 months ago What you’re saying about DHA and EPA on a plant based diet is not true. There are excellent supplements with DHA and EPA made from algae! Kasamahan Tv Kasamahan Tv 5 months ago What about the night shift that only sleep in morning? PRATHU TAYADE PRATHU TAYADE 5 months ago :) Medcare sklep Medcare sklep 5 months ago david don't read these ads. It looks poor. Outsource it to someone else or let advertisers provide graphics 1 Dr. Seku Gathers Dr. Seku Gathers 4 months ago 💪🏽💪🏽💪🏽 Falcon one Falcon one 5 months ago I used cassette tapes in my 1996 vehicle until 2011 when I got my first vehicle with a cd 💿 player. I just started pairing devices for music in 2020. Lol I guess I've been sleep 😴 💤 😅 😴 MPM Revolution MPM Revolution 5 months ago inspiring Michael James Squires Michael James Squires 5 months ago Aussie, Aussie, Aussie! I actively promote you for free, send me some Resveratrol as commission 🤣🤣🤣 Anita Flego Anita Flego 1 month ago Can we get athletic greens in Australia? pyy setä pyy setä 5 months ago Good Henni Annariina Henni Annariina 5 months ago Folic acid is b9 not b12….. 1 Anna Abrante Anna Abrante 5 months ago Foods have NAD. CUCUMBERS have huge amounts. Google it. korniszon68 korniszon68 5 months ago I don't sleep because I hear to David Sinclair podcast telling me I should sleep :] Adam Adam 5 months ago What can average human do to help this research? Petition to politicians, funding research? Marie Lou Marie Lou 5 months ago What is your opinion on Berberine? Jawad Karim Jawad Karim 5 months ago (edited) what about MCT oil like (coconut oil ) ! coconut oil is good or bad for brain ? starfox300 starfox300 5 months ago hm Matthew has been looking a bit younger Ray Stevenson Ray Stevenson 4 months ago Where do you stand on cannibas use, smoking versus nonsmoking, cbd and thc etc.? Mike 503 Mike 503 5 months ago If you're vegetarian I would get your omega 3 from DHA /EPA algae supplements. frank chen frank chen 5 months ago My hero，would you think herbal medicine could be a new direction？ Tahelle Wythet Tahelle Wythet 5 months ago yeah but, can you wiggle your eyebrows? 2 Frankasaf Scimone Frankasaf Scimone 5 months ago I don't think it looks good to advertise a product. 1 Ca Bo Ca Bo 5 months ago 💗 P W P W 5 months ago The content is interesting, but delivery rarely provides sufficient or succinct info for practical life application. Nirit Friedlander Nirit Friedlander 4 months ago I clicked on level’s link you share here but it says that the product is on progress..? tubo1812 tubo1812 5 months ago The podcast is good but this one and all I listened to are too centered in NMN which is not available everywhere and that makes it less actionable. Elide Cantero Elide Cantero 5 months ago Why does he promotes AG but he doesn't takes multivitamins? 1 The_Q_is The_Q_is 5 months ago I'm not understanding what David said he takes for sleep. It sounds like "anumen" or "enamen" Does anyone know what this is? Thank you! r91plays IND r91plays IND 1 month ago Botox all the way! 1 Stefan Stefan 5 months ago (edited) Folic acid is not B12 in case anyone was confused. I can’t take this guy seriously. Leslie Styles Leslie Styles 5 months ago What? B12 is not folic acid, that’s B9. B12 is Cobalamin. Diane Hafner Diane Hafner 5 months ago Athletic greens have natural flavors---a known neurotoxin?? I don't see how y'all can rec.??? As well as stevia. I know you won't answer but maybe someone that reads this will. 1 Tom Balley Tom Balley 5 months ago Talk about your Resveratrol lab issue european descent123 european descent123 5 months ago Hmm my dad has a long lifespan. كوتش منير كوتش منير 3 months ago Thaaanks Chester Copperpot Chester Copperpot 5 months ago Are you suggesting that people without diabetes go to their doctor and ask for a Metformin prescription? roc roc 4 months ago healthy 100 year olds please share your secrets here jn052159 jn052159 5 months ago with computers dna sequencing wheres the great discoveries...aint none Christian Grant Christian Grant 5 months ago He is FROZEN 1 First Last First Last 5 months ago 💚 Omega Watch Omega Watch 5 months ago Centrophenoxine Yang Mabel Liu Yang Mabel Liu 5 months ago Yeah!!! eliana eliana 5 months ago Do survivals of wars tend to live longuer? jamuga60 jamuga60 5 months ago Can you take say Tru Niagen and resveratrol together................do they work in conjunction? Sepp ImWeb Sepp ImWeb 5 months ago NMN is increasing homocysteine levels and bilirubin. This is very bad I guess. Why didn't you mention this??? european descent123 european descent123 5 months ago Ohhh god save yourself. shay stern shay stern 5 months ago get a pro instead of this guy and shorten the time on these Win Balingit Win Balingit 5 months ago 🤯!!!!!!!!! 1 Norseman Norseman 5 months ago Doesn't Dave support getting vaccinated? Talin Rowe Talin Rowe 1 month ago Can you connect this to my smart walker dym3nsions dym3nsions 5 months ago whats the youngest i can start taking nmn and resveratrol Flora Ciarlo Flora Ciarlo 5 months ago You look like in 1995....... 1 Toros Demircioglu Toros Demircioglu 5 months ago Videos are too long , you can Summarise like dr Eric berg ..it takes 1 hour but main things are just 10 minutes Alex Michaud Alex Michaud 1 month ago Can i have back my lost memory 1 Brad Stonestreet Brad Stonestreet 5 months ago Isn't that a reason intermittent fasting is recommended. Peter Coderch Peter Coderch 5 months ago This interviewer is terrible. Not only is he unintelligent and asks dumb questions, but he talks way too much and in fact talks more than Sinclair does. This is one of the downsides of having communication grraduates doing these interviews. Brent Nally, I think, is another example of one of these communication majors doing interviews with longevity experts. They go into these jobs because they are "people persons" and like to work talking to people. But this is not what I want in a science interviewer. I want someone that knows roughly as much as the interviewee. This is why i like Peter Attia's podcast so much: even though I don't agree with Attia's metabolism-approach to ageing, at least he is intelligent, he does know a lot of physiology and biochemistry, and above all he lets his guests speak and doesn't interrupt them all the time. 2 ehsan rezai ehsan rezai 5 months ago Hehe dtko dtko 5 months ago Your intro looks like you've stolen from Dr Huberman 1 Stephen G Stephen G 4 months ago What's your opinion of Dr. Amen-Ra? Yair Horesh Yair Horesh 5 months ago B12 is NOT folate. What an embarrassing mistake... James Frith James Frith 5 months ago For the Alg boost Albert Elizondo Albert Elizondo 5 months ago So a little bit of wine is good? There are so many conflicting opinions out there, is why I ask... NOTREALLY HANKAARON NOTREALLY HANKAARON 5 months ago No sugar. No refined carbs. No seed oils. Eat animals. Adaline - Free Leonard Peltier Adaline - Free Leonard Peltier 5 months ago 🗣🎧 Pixie Doodle Pixie Doodle 5 months ago Can anyone participate in your studies? JayB JayB 5 months ago Please respond to Dr Brad Stanfield's video. cholakicha cholakicha 5 months ago (edited) 50:00 Jay Jay Taljaard Jay Jay Taljaard 5 months ago So at the moment only USA and Canada can subscribe Rhizomio Rhizomio 5 months ago Computer says no. Cindy Cindy 5 months ago The co-host isn't that #DavidSinclair #Longevity #Aging Biotracking, Age Reversal & Other Advanced Health Technologies | Lifespan with Dr. David Sinclair #8 156,234 viewsFeb 23, 2022 David Sinclair 209K subscribers In the final episode of this season, Dr. David Sinclair and Matthew LaPlante focus on current and near-future technologies relevant to health and aging. In addition to discussing the utility of wearable sensors and biological age measurements, they highlight innovative research aimed at reversing biological age. The societal effects of therapies that successfully extend healthspan and/or lifespan are also considered. #DavidSinclair #Longevity #Aging Thank you to our sponsors: Levels - https://levels.link/sinclair Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Lifespan podcast website: https://www.lifespanpodcast.com Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsincla... Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclai... Stay up to date with David's work to democratize biological age testing and insights: https://www.tallyhealth.com Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante Timestamps: 00:00:00 Introducing Episode Eight: The Future of Anti-aging Medicine 00:03:49 Thanking the Sponsors 00:06:48 Modern Healthcare, Disease Detection, and Circulating DNA 00:11:30 Wearable Monitors: A Dashboard for your Body 00:20:31 Types of Health Sensors 00:24:20 Big Data, Privacy, and Criminal Investigation 00:30:16 Cutting-edge Testing and Biological Age 00:36:40 Using Personalized Data to Inform your Diet 00:41:48 Optimizing Exercise and Activity-mimetics 00:45:02 Resetting the Aging Clock 00:53:45 Repeatable Age Reversal and Safety 00:56:11 Longer Life, Population Size, and Economics 01:00:18 Skillbatical 01:03:06 Putting in the Work for Longevity 01:04:56 Thanking the Podcast Team and Wrapping Up Season One 01:08:27 Options for Subscription and Support Links: Affordable epigenetic age prediction: https://bit.ly/3nFeTto Waitlist for a new biological age company: https://www.tallyhealth.com Pharmacologically reversing age in humans: https://bit.ly/342XXGJ Restoring vision in mice via reprogramming: https://go.nature.com/335iysI Targeting aging is economically valuable: https://go.nature.com/3IgrQ4Z Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. Chapters Featured playlist 8 videos Season 1 David Sinclair 1,246 Comments rongmaw lin Add a comment... Little House in the Big Apple Little House in the Big Apple 5 months ago Oh, and PLEASE do a season two. There’s lots of us out here trying to figure this stuff out and the more data we have the more successful we can be! ✊🏼 373 Danovic Danovic 4 months ago (edited) Absolutely love this podcast guys!! I would watch every single episode even if there would be a hundred seasons. So yes, please do another season. 25 Super Blue Super Blue 5 months ago Awesome!! I loved every episode of this season. Really looking forward to season 2. I'm implementing alot of these suggestions in my life right now. Such as intermittent fasting, exercise, healthy eating, daily vitamins supplements. I'm now 43 and have osteoarthritis in my left hip. I was told its wear and tear from an active life of playing many sports. I was also told by doctors the condition is irreversible, but im determined to reverse it and eliminate the pain. I would enjoy a deep dive episode about inflammation in the body. I haven't read Lifespan yet but I will. I'm reading Life Force right now by Tony Robbins and it's mind blowing!! 26 Cheryl R Leigh Cheryl R Leigh 5 months ago Well done David Matt & team! Have enjoyed this series and would love a season 2. 133 Lena Konstantakou Lena Konstantakou 5 months ago We all love what you do, so we are looking forward to your next episodes. Fertility is definately an interesting subject. 9 Cassandra L Brecht Cassandra L Brecht 5 months ago As a menopausal woman, I'd love to see a deeper dive into hormones and how HRT affects longevity. 123 Dr Kaushik T Dr Kaushik T 5 months ago Waiting for many more seasons to come, Dr. Sinclair 🙌 71 George Evancho George Evancho 5 months ago Please do a season 2. I would love to hear more on red light therapy. 18 Daryl Sew Daryl Sew 4 months ago Loving this series!! Please do a season 2! Would love a Q&A session with viewers like an office hours. 4 Pete Pete 5 months ago David - I'd love to use InsideTracker but it's so expensive out of the gate, even with your code. For example, Ultimate + InnerAge is marked up double on the list price without discounts and multiple units. You're on the board - can you get them to lower their prices for first time customers (e.g. 50% discount)? Would be great to make this more widely available and allow people to try it out. Thank you! 98 Weronika Krynicka Weronika Krynicka 5 months ago (edited) Might be uncommon, I'd love a podcast on Epstein Barr Virus - how it relates to longevity, whether there are any sights for complete removal of it, whether those 5-10% who are uninfected live longer, is it even possible that apart from immunodepleting it could have some hormetic effect, etc.;) Thank you a lot! 3 Laura Caflisch Laura Caflisch 5 months ago For future episodes - would love to see a discussion on the microbiome. 67 Tonya Mckimmy Tonya Mckimmy 5 months ago Yes please, another series! Some ideas: Do emf's and things like cell phone radio frequency damage our cells to a point of concern or do they effect our longevity? More detailed information on women and menopause. How to optimize diet, exercise, and hormones during perimenopause and menopause. Treating Lyme Disease. Thank all of you for teaching us and at the same time making me chuckle! Love it! I love science and your podcasts help put hope back into my thoughts about our planets future which also restores my hope in mankind! Beautiful! 35 Sandra Tislo Sandra Tislo 5 months ago absolutely mind blowing, looking forward to listening season 2 2 Jodi Hoyle Jodi Hoyle 5 months ago I would love another season also! Thank you for using terminology that I can understand and is relatable. 4 Alexis Miller Alexis Miller 5 months ago Hi. I've been following Dr. Sinclair since 2015, have read Lifespan. I was wanting this podcast for years, so thank you. Please do another season. ...I and several friends have hypothyroidism and we're chronically under-cared-for, and I think under monitoring of our thyroid levels is a core reason. Q: Will there be continuous thyroid monitoring? I think this could significantly improve millions of people's lives both in health and subsequent personal and professional productivity. My potential has been significantly under-met due to lax thyroid health care. Thanks. 41 Fritzprogram Fritzprogram 5 months ago This podcast has changed my life in many positive ways. I can’t wait for season two!!! 3 Catherine Slavin Catherine Slavin 5 months ago As an almost 70 year old, this information is so helpful. The work you're doing is vital to people and will help all of us to remain healthy as we age. Please continue the series with deeper dives and to relay new information as it comes to light. Thank you so much for taking the time to make this information available. I'd love to see your analysis of studies on this topic. 24 Tristan Teo Tristan Teo 5 months ago Hi. Appreciate your work. Would like to hear your response to the recent resveratrol controversy that has been circulating. 18 Laurie Chapman Laurie Chapman 5 months ago Absolutely would love a second season, our medical system is generally too far behind to let us rely on them to keep us how to be healthy much less, teach us to age healthy! The current health insurance system also doesn’t encourage health so people need to take their health in their own hands and the information you provided was hugely helpful! Thank you again!! 2 Dean Earlix Dean Earlix 5 months ago Special request for future podcast seasons: each year, create a "Developments since [year of last season]. This would be the most exciting segment, and be the reason I rewatch each podcast from the previous year. More immediately, thank you so much for filtering, collecting, and interpreting this fascinating and vital research for us! 1 France Trudelle France Trudelle 5 months ago Love this podcast. Intelligent, coherent and comprehensive content ! Please don't end it !!!! Will keep my fingers crossed to see more ! Thank you so much for this amazing info. :) 34 Omar Sanchez Omar Sanchez 5 months ago We the people need season two Dr. Sinclair. I want to thank you for sharing your knowledge with the public. Between you, Andrew Huberman and Lex Fridman I see you guys as role models and mentors which have inspired me to take action in my live and try to live to my full potential. Dr. Sinclair keep up the great work the world could use more people like you. Thank you. 5 Sebids Weiland Sebids Weiland 5 months ago I'm somewhat shocked to learn this already was the end of Episode 1. I was under the imagination that this was going to be a weekly podcast, like with Dr. Andrew Huberman. I loved the podcast, and I'm sure the longevity space really needs this one major podcast where people can come together, just like in many other fields. I urge you to continue! :) 52 Joseph Siwek Joseph Siwek 5 months ago Awesome first season Dr. David,yes plz to season 2 bring your dad on for an episode. ALSO deep dive on microbiome. 8 Rayce Robinson - Your Favorite Florida Mtg Broker Rayce Robinson - Your Favorite Florida Mtg Broker 5 months ago I have been sharing this podcast with a lot of my friends, this info is extremely useful, you guys lay it out in a very concise and clear way definitely definitely do a second season. 3 Caroline Duncan Caroline Duncan 5 months ago Yes I’d really love another season please. Covering fertility in older women in one if possible. Thanks for your great work in podcast. 1 Cheryl R Leigh Cheryl R Leigh 5 months ago Timestamps from the info box: Timestamps: 00:00:00 Introducing Episode Eight: The Future of Anti-aging Medicine 00:03:49 Thanking the Sponsors 00:06:48 Modern Healthcare, Disease Detection, and Circulating DNA 00:11:30 Wearable Monitors: A Dashboard for your Body 00:20:31 Types of Health Sensors 00:24:20 Big Data, Privacy, and Criminal Investigation 00:30:16 Cutting-edge Testing and Biological Age 00:36:40 Using Personalized Data to Inform your Diet 00:41:48 Optimizing Exercise and Activity-mimetics 00:45:02 Resetting the Aging Clock 00:53:45 Repeatable Age Reversal and Safety 00:56:11 Longer Life, Population Size, and Economics 01:00:18 Skillbatical 0:1:03:06 Putting in the Work for Longevity 01:04:56 Thanking the Podcast Team and Wrapping Up Season One 01:08:27 Options for Subscription and Support 10 Ciarog Ciarog 5 months ago Dr Sinclair, Your'e so sincere and seem so eager to help us by bringing all of these developments to us as soon as possible. Love your enthusiasm,and CAN'T WAIT!!! 3 Adam V Adam V 5 months ago Seems like there's a lot of debate about resveratrol & sirtuin activation as well as the effects of metformin on longevity of non-diabetics. Would be great to have a quick episode detailing and refuting the arguments against those 2 things 15 Vicky Daisy Vicky Daisy 5 months ago I’m looking forward to hear the 2nd Episode of your podcast. Here are topics that need to be considered; female fertility and menopause, SIRT6 activator, Apigenin supplements and Ca-AKG. Thank you 😊 16 Lisa Nero Lisa Nero 5 months ago Loved this informative series. Please make more. They give me hope for the future xx 4 Khashayar Afshar Khashayar Afshar 5 months ago Would love to see this show continued! Thank you Dr. Sinclair, colleagues, and sponsors for the health-saving tips! 4 Zsófia Galló Zsófia Galló 5 months ago Please, please, please continue this fantastic content! (Listening from Hungary, btw!) 6 Pam Birkholz Pam Birkholz 3 months ago (edited) I'm 71 and exercise (walking everyday and weights 2-3 times a week). I started taking NAD after listening to one of your talks, but it sounds like I should take NMN. What dosage is appropriate? Do you recommend a company? What should I consider before I start the regiment? I love listening to your series and have learned a lot about avenues to pursue for optimal health. I am not diabetic so I have no idea how I would get metformin. Thank you both. 1 Popel Grüner Popel Grüner 5 months ago Glad to hear that this is only the last episode of the first season and that you have at least a second one planned. I am grateful for this informative podcast. Thank you! 21 Joyce Sloan Joyce Sloan 5 months ago Love love love the series- thank you!! I’m a 71 year old healthy female and would appreciate hearing more about later in life age reversal- a deeper dive- what to expect- when is it too late. Also knowing that cancer cells are always circulating but not always a problem- can testing prematurely detect a problem ? 25 rando- me rando- me 5 months ago This is among the most exciting and inspirational series I’ve ever watched. The Lifespan book was excellent (and inspiring) and I’m on the edge of my chair waiting for the next thing you guys do. Thanks. Errol Getner Errol Getner 5 months ago I looked forward to each of the 8 episodes. Totally in favor of a second season. 1 Creighton Freeman Creighton Freeman 5 months ago Yes. Do another series. Actually it would be great if the podcast became an ongoing podcast. There are plenty of biomedical topics to discuss, and if you get tired of talking about your work bring in some of your colleagues and discuss their research (George Church, Steve Horvath, et. al. ) 11 Tomas Anthony Tomas Anthony 2 months ago David and Team: Thanks for this series and especially the message at the end: When our parents are healthy and given the science to make decisions to live rich and longer lives, they can provide insight for us, as their children, to impart knowledge and make better decisions. After reading and following the work in the field for many years, I appreciate your time in making this series. Would also like to hear your thoughts on the following given the challenges we face today as a society where a large number of people deny the importance of the scientific method or science overall. How does your team view this work in the larger context of society? What about the mental health of individuals and communities? Would you agree that it seems at times that a large portion of the United States population seemed to be suffering from irrationality in their denials of science? Or that the pandemic exposed that weakness of education due to the fact that many people were and are easily manipulated in dangerous and destructive ways? What are the ways you think we can counter propaganda, lies, and non-scientific ideas to prevent the premature death of hundreds, thousands even millions of people? One could argue and suppose that Darwinian evolution works across all levels of human existence - but that would be callous and untrue. How can we fight these forces that harm our society as a whole, put us all at risk, and limit the ability to fund important science like this? If our goal is to build and produce rational thinking humans, and maintain a functional society that believes in science, what can be done better to promote and educate people on all levels so that they can make better, more informed, and science based decisions on their health? How can leaders in their fields (like yours) work to overcome the manipulated fears of these everyday people whose ignorance is being preyed on for profit or political gain and putting everyone at risk? How can we raise a healthy generation of science believers that ensures that as human beings we fulfill our potential for good as a species for every living thing and not just ourselves? I realize these are big questions but your work provides the timeline for each us to answer them and solve them no? I hope so! Best to you and your team! HardForking HardForking 5 months ago Best podcast there is, will be one of the biggest in quick time, keep it going please. 10 Dahs K Dahs K 5 months ago Please please please keep these going!! Thanks for everything 6 Chantal Pique Chantal Pique 5 months ago Dr. Sinclair, It's a great idea! Please, let us know where we can get the utility of wearable sensors and biological age measurements? 1 Lowkey Fish 🐠 Lowkey Fish 🐠 3 months ago Absolutely love the podcast David! I watch every episode! Some even multiple times lol. I love everything about what you are doing for the medical field in it's entirety and I wish you the best of luck in all your future endeavors. Much love and sending good vibes your way :-) 2 Aum Aum 5 months ago High quality content, thank you gentlemen. 10 Łukasz Jagodziński Łukasz Jagodziński 5 months ago Please do the next season. Some things I would really like to hear about are: - How does your work look like? What are you guys doing on daily basis? What are you focusing on right now? You mentioned that you have a lot of startups dealing with multiple things. If possible, could you give more insight on each one? Would be even more awesome you did some guided tour around your lab. Maybe even do podcast in the lab and invite your teammates to talk in the podcast. - What about the human trails? Once you said that US army approached you and you're doing some trails for them? Can you reveal anything about it? - Could you talk more about those bio trackers? Just show some charts from them and maybe tell about discoveries you made over time by measuring your body? It's great to know that those trackers exist but just seeing some examples with data would be really nice. - You mentioned once that you use a lot of advanced technologies that wasn't available just a few years ago, like for example AI. Could you talk more about the usage of those technologies? Why you use them and how they speed up the process? canal47100 canal47100 5 months ago Please do a second season!! This is great- I feel very optimistic about our future thanks to Dr Sinclair, his work, and the efforts he puts into sharing it in a way everyone can understand. Please include female reproduction in a future episode. I cannot wait. Thanks again, fantastic show! 12 Claudia Fernandez Claudia Fernandez 5 months ago I never liked Wednesdays so much until Dr. Sinclair started his podcast. Thank you! 7 Basia Pio Basia Pio 4 months ago Thank you so much for taking the time to do this podcast! It's invaluable and life changing! Please do continue! I'd appreciate a deep dive into microbiome, IBS and brain-gut link. 1 Rob Rob 5 months ago I've enjoyed season one, although I feel like sometimes it can be hard to take away practical advice that can really be put into use. A lot is very in-depth scientific discussion which i enjoy, but come away thinking there's not much new I can actually implement MilNOR MilNOR 5 months ago Would love a season 2! 12 Contretemps Contretemps 5 months ago Guys this is treasure! We definitely want the series to continue. Topic suggestion, though may be covered many times before, we still want to hear it from you, how stress affects our body, brain, hormones, immune and cardiovascular system, mental health and everything.. how can we trace the destructive effects of it in our systems and reverse it? Thank you a lot for all this valuable information. 1 María Isabel Quiroz María Isabel Quiroz 5 months ago This is such great content! 5 Joe Htoo Joe Htoo 5 months ago Love this series! Thanks David and team 10 Mayra Kennedy Mayra Kennedy 5 months ago I can't get enough of all the information on your channel. I actually just got my Levels CGM. Now I've been using it for 1 week. I'm trying to learn all the spikes and meaning to improve my health. LOTS to learn. Episode suggestion :-) what to make of spikes when eating healthy foods, what is good and what is bad. I'm not diabetic. I'm an athlete and trainer so my glucose is not average. Thank you!! 1 10nut 10nut 4 months ago Great season, I'm looking forward for the next one! Thank you for your optimistic perspective. You are making a great team! 1 Morgan Svensson Morgan Svensson 5 months ago (edited) Love this series guys. 👍Please keep the videos coming. 😊 We all need more in-depth knowledge on basically all the topics you have been talking about. That's literary thousands of episodes if we break it down piece by piece.🥇🥇🥇🥇🥇 17 ronie Sousa ronie Sousa 5 months ago 😱 OMG !! I have been learned so much with David Sinclair! English is my third language so I go back and forward with all those informations to understand better and pass on to my relatives ? Thank you so much both of you , I love to hear everything even the sponsor for the interviews lol 😂 You both are very funny too! 😂 thanks 😊 1 That Chess Guy That Chess Guy 5 months ago I’d be interested in a series similar to 2 minute papers (a YouTube channel) where David talks about his favorite paper(s) of the past week or month relating to aging. 5 Dinky Dangles Dinky Dangles 5 months ago I'd love to see an indepth episode on diet and what specific foods and recipes you use David! Thanks for your work 3 Paprika Veg Paprika Veg 5 months ago This episode was my favourite, the positivity about the future ahead and the options to use all of this valuable life extension for the benefit of human population was really well put. Hopefully it will work as planned :) Belinda Mayson Belinda Mayson 5 months ago Thank you so much for this podcast. Looking forward to another. I am 73,type 2diabetic,a heart patient with pacemaker,hypertensive,but listening to you gives me hope that I can reverse my age and live to my 90s,healthy if I do the things you suggested for longevity...isn't that great to look forward to❗👏 2 Purity Wanjiru Kimani Purity Wanjiru Kimani 5 months ago (edited) Please record season two! Super interested in hearing all about fertility and aging! 3 Isabelle Innocenti Isabelle Innocenti 5 months ago I'd love another season! I'd like to know more about how to reverse grey hair color back to its original color, I'd like to know more about ideal lifestyle factors for women who are breastfeeding, and more info on how to delay or reverse menopause, and how to optimize DHEA levels. Many thanks! Jalil Mloukhiyeh Jalil Mloukhiyeh 5 months ago Another excellent episode and great way to end this series. Can't wait for future episodes where you actually announce trial results and actually make recommendations on actual suppliments/meds that work best at extending healthspan!! Thank you for you contribution to humanity! :) 8 Cathy L. Cathy L. 5 months ago That season was very interesting: giving exxxxcellent and accurate information. Please keep going with your awesome job (both of you and all of your team). So nice to be informed on the new development in this field. Thank you for doing that. I REALLY appreciate you. 6 Norma Mannix Norma Mannix 5 months ago Absolutely continue with Lifespan Season Two! I have learned so much, applied some suggestions, and am working on applying more! Thank you, David, Matt and Team! 2 JM S JM S 2 months ago This was fantastic, and i would love a season 2. I would also love to hear about the impact, if any, on autoimmune disease, and more indepth on menopause in the case of "severe" post menopause symptoms, beyond the ordinary hot flashes. There are a lot of us out there. Cat Steinhilb Cat Steinhilb 5 months ago Truly appreciate his entire series, thank you so much . I know one person who’s life has literally changed in 3 weeks after I shared a few episodes ❤️ 3 valerie ramos valerie ramos 4 months ago I am Obsessed with All these videos… I’m learning sooo much and it makes me so Hopeful on a Longer healthier life for our Kind. Thank you so much for sharing. And YES for a season 2. Maybe more on Menopause and healthier aging for women and fertility. I went through that and I’m sure that would help so many women in their child baring age. Marlene DeLaTorre Marlene DeLaTorre 5 months ago I read your book Lifespan and also listened to the audiobook… I have been listening and following your work ever since.. So many voices out there.. But it’s been your voice and Matt’s that I been truly tuning into.. I see your sincerity and yes I am sure a very good businessman and scientist.. I see humility and your drive for truth and excellence.. I am right now listening to Tony Robbins Life Force, and he mentioned you and your work.. You are touching many lives..And don’t give mind to the naysayers.. because they will always be with us… God bless you David and Matt.. Keep working hard… Surround yourselves with good people.. Keep moving forward… 2 Maggie W Maggie W 5 months ago Loved this series. Have been following you on other channels where I realized that I need and appreciate solid and verifiable information to assist me with my health challenges. This is the best resource ever. Heartfelt thanks and hoping you decide to produce a Series II. 5 joey joey 5 months ago (edited) Love this podcast. Please do a second season with an episode focused on stem cell treatments for orthopedic injuries. How does 'homing' work? What diet should be followed before and after treatment? The difference between stem cell treatments offered in the US vs. abroad. All things stem cells! Rosie Rosie 5 months ago (edited) Thank you Dr. Sinclair, you make science so fascinating and thank you Matt, the two of you make these podcasts so interesting. 1 Andrea C Andrea C 5 months ago Find your content fascinating and put in a way that is easy to understand. Not just the what, but the why and how of it. Thank you for the education 🙏🏼 . Will be sad when this series is up. 4 Steven Do Steven Do 3 months ago I’m all for season 2! The content is invaluable!!! 1 Dianne Laheta Dianne Laheta 5 months ago Would love a season 2. Peter Attia and Phil Maffetone have done a lot of research on the benefits of Zone 2 training for longevity. David has highlighted that adding stressors are good for longevity. Could you do a podcast comparing the research? Is it either/or, or more of a both/and approach for longevity. 2 Lori Douglas Lori Douglas 5 months ago Happy to keep listening. Looking forward to the next series already. I love the idea that humanity will become responsible for their own health although Big Pharma may not like that 3 Lorene Lorene 5 months ago I’m hooked. Would love a season 2, info on sexual performance especially with regards to post menopausal women, and any link between aging and the gut microbiome. 💚 sf sf 5 months ago Hi guys, quick topic suggestion: I'd love to see something like a fact check on Traditional Chinese Medicine, meditation & tea ingestion (as a pool of topics and framework) - especially with regards to wellbeing & aging. Like what REALLY has some scientific, peer-reviewed background and what doesn't so far? Where do these ancient eastern and modern western practices have commonalities? And how could one use this in his daily life as an addition to what we've learned so far in your podcast? Cheers :) 1 Words Words 5 months ago (edited) Yes , please do it … Very precious information you’re giving us! Thank you and your team 🙏 2 Joya F. Joya F. 5 months ago Couldn’t wait for this podcast to start and it didn’t disappoint! Loved Lifespan and really appreciate your work at Harvard, your other company’s research, your commitment to the science and spreading the word for the good of society in the future. I’m now committed too and will help spread the word/podcast/book so more will join us. The potential topics for Season 2, 3, 4, etc. are limitless. Lori Douglas Lori Douglas 5 months ago (edited) Great series! You’re providing such relevant information to the public. This episode specifically leaves me grateful that I grew up during times of anonymity. This implications of these devices and the data they produce terrifies me. I may take my chances thanks 2 luhark9 luhark9 5 months ago Listen carefully - many good points and Lifespan was worth a read as well but this could also be considered one giant infomercial/commercial. Continues to mention the sponsors and other companies even outside the sponsor/advertising segment. 3 Marc Charach Marc Charach 1 month ago This has been amazing and I am so grateful to David, Matthew and the team for spending so much time to explain all the science in a way that even though it gets quite technical at times, it is still enjoyable to watch and fascinating to hear. You have already contributed immensely to my current lifestyle change by recommending fasting and more exercise and I am already feeling great. Please make season 2, I can't wait. Thank you so much! Maestro Dimyan Maestro Dimyan 3 weeks ago Absolutely fantastic! Now you Have to create season 2 because of the responsibly you guys took once created season 1. People are in love with your work and science behind it. Please continue! A+++ 1 Armando Miraglia Armando Miraglia 5 months ago Definitely waiting for a 2nd, 3rd, and more seasons :) 2 Hèctor López Laguna Hèctor López Laguna 5 months ago Love to have a season 2. Absolutely outstanding and brillian poadcast. I would be interested to know how to optimize human performance and recovery. A huge hug! rebaked rebaked 5 months ago This was an amazing series. We know you are a busy man, but we are looking forward for a new series 😁 2 Budding Millionaires Budding Millionaires 5 months ago Keep 'em coming! I love this information and staying informed helps me stay motivated. 3 Debra Debra 4 months ago First, thank you for this series! I feel much more in control of my health. Second, PLEASE do an episode specifically on Alzheimers. During this episode you guys made two comments that left me very curious. My mom is in advanced stages of AD and I now live in fear for my sister and myself, which I know is not healthy! Please consider disease specific episodes. Thanks again! BE G BE G 13 days ago Love the podcast, and hoping for season 2! I would love to know more about how to lower low grade cronic inflammation because many suffer from it and it causes so many issues that could shorten life like heart disease and cancer. Soybeans Soybeans 5 months ago (edited) Yes, please have a second season. The information is exciting, informative and digestible. Thank you. 2 blason71 blason71 3 months ago I've just finished this amazing series. Thank you so much for all the great information. Please do a season 2 and 3 and 4, etc. 😂 1 Danielle Morris Danielle Morris 5 months ago I love you guys and your work. Looking forward to seeing you both next season 🤘😁 2 Charles Ryan Charles Ryan 5 months ago Why did you block Dr. Stanfield? 3 Nopsat Racing Nopsat Racing 2 months ago Absolutely loved the series! I definitely would like to see more! It's funny how doctors, nutritionists, fitness professionals etc have always told that eat every 3 hours and concentrate on protein intake. And yet you should avoid that. I've debated these things a lot with my friends and the wife. They don't believe anything I try to tell them =D Club Hexico 2036 Club Hexico 2036 2 months ago (edited) Loved this podcast series. Thanks for making it available for free. Would definitely be interested in a second series. Maybe it's not in your wheelhouse but I would like to hear more about stem cell research in relation to spinal cord injuries. I bought the book for my mother and my uncle who is paraplegic. On NMN supplementation, we should get a full health check up and make sure we have no cancer cells present before taking it, right? Christie Array Christie Array 5 months ago Absolutely love these thank you so much 🙏 I am a health coach & have women in their 50-60s, would love to know more tools I can give them to help them lose weight /thrive faster easier thank you🏆🏆🏆!!! 1 MsAdo1 MsAdo1 3 months ago Thank you for an interesting season. I still hunger for more insights into research around hormones and the implications on later-in life changes (obviously with longevity in mind). I am female and in the middle of menopause - what would happen if I instead of taking estrogen, which as you pointed out are linked with breast cancer, took some androgens? And what would happen if a woman stopped ageing in the middle of her menopause? Would she be stuck there, treating symptoms and not feeling "balanced" for want of a better word? Also, I am glad you mentioned the difficulty finding brands that are trustworthy and or recommend the right dosage etc. So far I have only found NAD+ supplement suppliers, and no companies that sell NMN that I have any chance of vetting. Maybe you could discuss ways of easily getting recommendations of purity and dosage for veed brands etc? Healthiest Happiest Well Being Healthiest Happiest Well Being 1 month ago (edited) Yes up for a season II ❤️ just got a great idea for my next content site - Internet of Body as I already have an IOT site 😉 I’m also a practicing yogi so understand the wholistic health of the body spans the meta physical realm which I’d like to explore and converge both truths! Support your continued work in all related fields 👏 Cheers Phil Alexander Thomas Alexander Thomas 1 month ago (edited) WOW, I have learned so much, which makes me hungry for more. I first saw you with Andrew Huberman then found your YouTube / Podcasts! Totally blown away with what I have learned! I am already applying many changes to my lifestyle based on information you provided. I have also turned on several others to your presentations. I am going to explore Athletic Greens, Inside Tracker and Levels to get more information to use with my doctor and cardiologist. This is information that everyone needs to hear. YES DEFINITELY DO ANOTHER SERIES!!! Please!! Lyrical LoopHouse Lyrical LoopHouse 5 months ago Im wondering if the reversal of blindness in the mice would also work for other diseases that cause blindness such as diabetic retinopathy? Thank you for everything @David Sinclair ! 1 Nan Johnson Nan Johnson 4 months ago Amazing information that has totally changed how I approach life. I listen/relisten nearly daily for motivation. It’s so exciting to hear the advances being made in these areas. There are too many poorly-aging folks who are sitting in nursing homes and breaking my heart. I pray our futures look different! Keep it coming! Jorge Martinez Jorge Martinez 4 months ago Several months ago I read Lifespan and was impressed and excited about what the future holds in this matter. I thank Dr Sinclair for his work and contribution to humanity. This first season has been a great complement, I hope they continue with their academic and informative work, we are all getting older and we need it. Marie Dawn Lam Marie Dawn Lam 5 months ago Thank you so much Dr Sinclair and Matt! I’ve been listening to all 8 episodes and am so inspired and motivated to continue doing what I’ve started doing after I’ve witnessed how my dad spiralled downwards in health in his 80s. I’ve started to eat right, learnt to intermittent fast and have been exercising daily, reducing not only weight but fat % and am looking much younger than I was even though I’m already 50! So I’d love to hear out your next 8 podcasts! Alex Nutter Alex Nutter 3 months ago Yes, please do a season 2. This is fascinating stuff—I’m 31, active and constantly trying to optimize my health as well as my friends/family and your guys’ info has helped in so many ways! Thank you F NE F NE 4 months ago Here's what I would love: Some episodes that apply to the absolute fitness maniacs. What about those who workout twice a day every day at extreme intensity? What is different for those people? Should they double the amounts of every supplement? Does Berberine apply to someone like this who already has glucose at 80? And so on... Roman Rubtsov Roman Rubtsov 5 months ago (edited) Thank you for making such a great podcast. Implanting these ideas into the daily routine helps to maintain the right balance in life. It would be great if you decided to make the second season. Among the topics I would be glad to see: "sleeping routine", "memory boosting", "cognitive exercises", "the role of stress for health in generally". What helps me the most in keeping my diet is my studies and the understanding that I am doing something useful for me, my family, and, further, I hope, for the society. I think that if you see the meaning in what you are doing, the new habits are implemented rather easier. I think that people struggle a lot with changing the diet not because they have not enough will-power (it is rather abstract, to my mind), but because there is not much in the life that supports this will-power. What could possibly support it? This is sadly a matter of some different podcast, but it would be great if real scientists did it, science-based as good as this one. Majid Nabavi Majid Nabavi 1 month ago Hi Prof Sinclair, while I thank you for your great research and scientific work, I would like to draw your attention to one important aspect of your approach. By informing people about potential benefits of NMN and other molecules you are taking and not revealing the reliable brands, you are exposing people to numerous low grade or even dangerous products out there. This could potentially harm or seriously damage the health of innocent people who just want to be healthier. Why not reveal a couple or safe and reliable brands? 1 S Nelson S Nelson 4 months ago (edited) Loved all 8 Podcasts and learned a lot. Thank you for all you do for everyone! I live in Canada, so ordered the NMN & Resveratrol powders from Alive by Science. In Canada we can't get NMN and can get a very grey looking Resveratrol in capsules only ... plus doctors here won't give Metformin unless you have diabetes. Doubt if Inside Tracker can come to my home to do blood work - ha ha. As I have RA, I get a LOT of blood work done every 3 mos here in Victoria, BC. Is there a SPECIFIC blood test that I should ask my doctor for? DoubleUnderFIRE DoubleUnderFIRE 5 months ago Great series! I would like to suggest another season with some time dedicated to the financial markets' outlook on longevity research. For instance, I think it would be fascinating to hear if there are ETFs or mutual funds that have a mandate to track emerging technologies related to longevity. anotherusrname anotherusrname 4 months ago Season 2 please!!! More on fertility sounds really interesting, maybe autoimmune diseases, and for sure more on any developments in longevity like this episode. Sen Sam Sen Sam 5 months ago (edited) Hello Dr. Sinclair and Mr. LaPlante, I'd like to offer a suggestion that I believe many would find fascinating for your second season! I'm a personal trainer, and I can tell you thousands of stories of clients of mine losing weight, gaining muscle, increasing strength, increasing flexibility, increasing cardiovascular capacity, etc. I can give you real examples of their progress using numbers (bodyfat percentages, powerlifting totals, Vo2Max results, flexibility scores, etc), and how they relate with time (it took this person exactly X months to take their metric from Z1 to Z2, while taking another person Y months to accomplish the same thing). I was wondering if you could PLEASE devote an episode to giving some real stories of people accomplishing biological age reductions according to the Inner Age test. How did they did it? How much younger did they get? How long did it take? What are the average results? What are some outliers? What challenges appear to pop up very often? What trends appear in the data? Etc. Thank you! 1 Anthony Bagala Anthony Bagala 5 months ago I turned 50 in November and I notice I’ve been listening to David Sinclair more and more. The advice is invaluable and inspirational. Karen Farley Karen Farley 5 months ago I have LOVED listening to you guys! I seriously have been looking forward to Wednesdays for the past eight weeks. Please do another series! And come to Utah for sure! Maybe I can meet you guys in person. Ha ha. I am a 44 year old woman and would love to learn about health care concerning menopause and specifically how to regulate hormone levels during that time. I would also love to learn some things about increasing my sex drive and my ultimate enjoyment of sex! Thanks so much for all you guys do! I look forward to hearing more from you. Shirley Lum Shirley Lum 4 months ago You get 5 stars! There's so much and I would like to hear more and yes, Season Two would be awesome. Michelle Chang Michelle Chang 4 months ago I have watched all 8 episodes of this talk, i have to say that it's been an eye opening and educating shows, it gives people hopes and direction towards the healthier and longer lives. I'm so excited to share this informations with my physicians and friends.....thank you very much for Dr. Sinclair for sharing your knowledges and passions !! Gilbert Flores Gilbert Flores 5 months ago Thank you for the show, I have learned so much from your podcast. Season two would be Great. 清水栄梨瑚 清水栄梨瑚 1 month ago This series is just amazing. I will be really looking forward to season 2. Don Rounds Don Rounds 5 months ago I love this one for all the tech. This is such an exciting and innovative area and I cannot wait to get my hands on the near-future gadgets and services to enjoy a healthier and longer life! Hassan Syed Hassan Syed 5 months ago Although, I was already more careful about what I eat but after watching your videos I am more conscious and make better decisions before eating anything 2 Harvey Castro MD Harvey Castro MD 5 months ago This is great!!! I hope you guys do another 8 this spring :) David Sinclair Adriana Heinzen Adriana Heinzen 5 months ago Thoroughly enjoyed this podcast! Would love to see more seasons! Thanks for sharing your knowledge and expertise in the field 😄👏🏼 Tímea Tüttő Tímea Tüttő 5 months ago Please do another 8 (at least)! It's been a life-changing experience, thank you! 2 Patricia Stark Patricia Stark 4 months ago Please continue! We need this kind of wellness information. I tell everyone I know about your podcasts. It deeply saddens me when I see so many overweight adults and children that are ill or will become ill as they age due to lifestyle and diet. We need education to learn how to take responsibility for our own health. You are doing us a great service! Thank you and carry on! Lets Go Media Lets Go Media 5 months ago Great content!!! Please keeping doing these!!! For content, very interested in Future technologies: now and theretical possibilités. And discussing the idea of immortalty. 2 Elevate Minds Media Elevate Minds Media 5 months ago Fantastic! I really appreciate and value the energy this team has invested and will continue to invest to providing quality information and science about health and aging. I'm very grateful for this series and am excited to hear you may make more! Thank you! 🙏 Gizmo Loft Gizmo Loft 5 months ago Will love another series, really enjoyed this one. If there is an online course to learn more about anti-aging (hint hint), I will happily subscribe! Lisa Harris Lisa Harris 5 months ago Thoroughly enjoyed this series! Please do a season 2, and thank you so much for sharing your knowledge. 🙏 1 Joe Hahn Joe Hahn 5 months ago I absolutely loved your Season 1 series for improving society's lifespan and the quality of life from birth to the end of life! This is amazing progress that will impact everyone and their loved ones! This provides hope to families who have a loved one who has alzheimers/dementia, heart health issues, pulmonary issues, or cancer etc. There is also the mental health issues like depression, PTSD, ADHD, or autism. Then there are children and adults who have low self-esteem because they have turned grey or balding before they were 30 or 50 years old or they have bad achne or a form of dermatitis. Many seniors suffer from age-related macular degeneration and eventually lose their driver's license and their independence. There is so much that can be done to improve the quality of life for people of all ages while resetting their biological clock. Thank you for the work you have done and the work that will be done as a result of your efforts! tramsgar tramsgar 5 months ago (edited) Thanks for the episodes this far! Topics of interest for future episodes: 1) Possible solutions to integrity/privacy vs "big-data-medical-monitoring" 2) Sociohistorical implications of commonly vastly longer lifespans (for eg "will people in general start caring about what they do to our planet today if they know they'll be around for much longer?"). Also, please try to have expert guests joining on specific topics. 1 Delirium XL Delirium XL 5 months ago PLEASE do a S02. I'd love to hear about how to get involved and where with something like this. Michael Michael 2 weeks ago (edited) I love the dynamic of your guys relationship, you can tell your total bros, and your differences in personalities compliment each other to make this an awesome, informative, and productive talk, while also being incredibly entertaining and a joy to watch and listen to kimmyyqjohnsonful kimmyyqjohnsonful 5 months ago First of all, I want to thank you both for being my faithful running partners! I find the podcasts to be very interesting and educational, and look forward to them. Please continue educating us! I'd like to hear a podcast on fertility as it relates to age, and if there is any hope for my "old" eggs :) Ty Harmon Ty Harmon 4 months ago This information is so important for the general population and legislators to know and prepare for. Please keep educating the public!! SEASON TWO HERE WE COME 1 WALTER SATTAZAHN WALTER SATTAZAHN 5 months ago Thanks for your work. I have watched you on Andrew Huberman’s podcast and Lex Fridman. I think the subjects you mentioned for future podcast content are important in many people’s lives. I would like to add that I think all the supplements and devices take time to understand. It can be overwhelming at first to learn about the existence of these things and then to do your own research on each one. I am not sure how to make that easier and to stick to only trusted sources, but it looks like there are some websites that are trying to do that with their “deep dives” on David Sinclair’s daily routine. I guess that also goes against doing what is best for your own body and not just doing exactly everything David Sinclair does. Also by reading some comments, it seems like a lot of people are wondering if Athletic Greens works. Lex and Andrew also mention Athletic Greens as their sponsor. 1 Erika Ihasz Erika Ihasz 4 months ago Loved season one. Yes, please do a season two. An episode (or two) on inflammation in the body would be great. Also gut microbiome deep dive. There's a lot to learn about pre, pro and post biotics. Beneficial supplements (D, Omega-3, Collagan). María Valentina Zamora Blanco María Valentina Zamora Blanco 4 months ago Hello ! I´ve really enjoyed the episodes. I have gained a lot of understanding on this issue about extending lifespan by practising a healthy lifestyle. I am trying to find my own protocle and would like to achieve results in the short term beacuse, as you said, my family deserves it and also me, of course. I have a comment on the illnesses that appear at a young age, children suffering from cancer and other deseases. If they are so young and should have all those levels of youth DNA at the top, why do they get sick? Could you explain this? Play Frame Play Frame 5 months ago Guys podcast is something that I was waiting for for about 5 years. Keep it up! 1 Bacon Invader Bacon Invader 5 months ago Love this podcast! Would love an episode on the relationship between aging and sleep Stephen Bethke Stephen Bethke 5 months ago A very informative series! I've changed my lifestyle as a result. I look forward to some of these interventions being available in South Africa at a price I can afford. Hope to see another series! Joyce Goglio Joyce Goglio 4 months ago So Grateful! Please, absolutely give us another go around of scientific factual information on the science of longevity! I really want to know where to source the supplements. At 70 I need to get a jump start on the whole process asap! Again with Great Appreciation for your dedication and Humor! Adam Adam 5 months ago Definitely want 2nd season. So much inside for health and ageing. My dad has some issues and best thing I could wish for my coming birthday is that he would be as vital healthy etc as he was in his 20’s. Your research will do a lot of good for society. Really appreciate your hard work. Humanity needs people like you. Also if you need money for research people can fund it, I would give 25$ for example and I’m sure that it will be spend right if you make it transparent. 1 Costel Corbuleac Costel Corbuleac 2 months ago Thank you! It would be great to have a season 2. One great topic, at least for me, is to know the relation between aging and muscle building, as I feel like those contradict on their use of mTOR Manoj Padki Manoj Padki 5 months ago This has been a fantastic series. Thank you very much. I do hope there is a Season 2 - & 3 & 4 :) 1 photon atom photon atom 5 months ago 5 stars! Yes, please do another season to go deeper on supplements, measurements and Dr Sinclair's new book (?). Thanks!! cherifa swearingen cherifa swearingen 4 months ago This was an amazingly informative series. Dr Sinclair I had read your book lifespan when it first came out, These episodes make it come alive. I have been following a plant diet and exercising for years. I would love to do the inside tracker testing, but it is so expensive. Is there a way they could lower their pricing? PLEASE CONTINUE THESE PODCASTS - THANK YOU FOR WHAT YOU DO. Super Heroes Super Heroes 5 months ago Please continue this incredible podcast! I’ve had the luxury of experiencing the benefits that Dr. David Sinclair has influenced me with. I used to struggle with sleep apnea and in general had a rough time falling asleep but due to David Sinclair‘s wealth of knowledge in the genetic Field of research I have booster my NAD levels and that was the start of my life improving tenfold. Now I have the natural energy to go to the gym and eat cleaner which has increased my benefits alongside that 1 Susette Susette 5 months ago (edited) Thank you for all the information! In the future I would like to learn more about woman's health (not only fertility! also about the future of contraception, if there ist anything new in the sciece), about PMS, PMDD, Premanopause, Menopause and all hormone issues around that: I would also raise a question about the impact of xeno-oestrogens in water and kosmetics. How can wie prevent osteoporosis, dementia, cancer and other age /hormone related deseases. I've watched your episode about kosmetic aging where you talked a lot about mens boldness, and would like to learn more about reversal of aging of womens skin and about connective tissue issues like cellulite, stretch marks, varices and prolapses of the womb. Why do women tend to constipation, insomnia and depression more than men? And also about womens psychological health and things like depression and emotional instability and resilience, and about supplements, women should take. I would love if you could address several episodes only to women's health. Thank you in advance. Grant Burris Grant Burris 5 months ago David, I've enjoyed each episode. I'll watch any additional episodes you produce. I really believe in your research. Hopefully, you can turn the knowledge into dollars so that you can continue. I have mentioned you to several of my friends who are in the medical field. I hope the financial interest will propel you forward. Good Luck. 1 dym3nsions dym3nsions 4 months ago Thank you for your work. and absolutely do a new season we would love that Susan Grady Susan Grady 5 months ago Thank you, David and Matt - so fascinating and hopeful for all of us for today and the future well-being. Getting my bloodtest tomorrow for InsideTracker! Patricia Soza LAc. Patricia Soza LAc. 5 months ago Yes please continue. This has been so educational, helpful and instills hope in people. I have been telling all my patients to listen to your podcast if not just to instill hope in them. Thank you for doing this! 1 GoneWithTheBlastWave GoneWithTheBlastWave 4 months ago Yes, please continue with a second season! I love sharing your podcast with friends and family. It has lead to great conversations about health and life. I had a great time talking with friends about mailing poop in the post. It was a great highlight of my day (I still giggle thinking about it)! Also, I am always on the lookout for whereever your work pops up next. Any interview, podcasts, or book appearances goes to my watch/read list. (I am a big fan)! Thank you for bringing your enthusiasm, critical thinking, and hope to the arena of health and longevity! 5 star review from me! May Lady Fortune and the Sisters fates bless you and your family! Anita Anita 5 months ago Looking forward to a Season 2 please!! 👍🏼👏 2 Suresh Rattan Suresh Rattan 5 months ago Well done and thanks - good coversations, generally correct and latest science although sometimes a bit too much enthusiastic giving a feel of "oversell", but worth it. Happy to hear repeated mentioning of my favourite term "hormesis"..!! Mary Baby Mary Baby 4 months ago Please continue with the podcast I would love to a season 2 on fertility and aging. Dr Sinclair you look remarkably youthful 😃 Lisa Marie Lisa Marie 5 months ago Another series please! Topic: Reversing Arthritic Joint Damage. Is It Possible? Thank you David and Matthew 🙏🏻☺️ 1 Lisa Duffin Lisa Duffin 5 months ago I would love a season 2! Would love to have this information in written form as well for reference. Thank you for your work and how you are making the world better by sharing your knowledge! Egg Mendy Egg Mendy 5 months ago Incredibly interesting information, and such good presentation. Love it, thank you for your work, Dr. Sinclair! Jona Halldors Jona Halldors 2 months ago Please do the season 2, I absolutely love your episodes. thank you for sharing this amazing information スピリジョン スピリジョン 5 months ago I'm keen to hear season 2! As for suggestions, definitely, sexual energy is a good topic to cover. My other suggestion is a philosophical deep dive. I know you've said things like by living longer we can try second or third careers and try new hobbies, and I wholeheartedly agree. But I don't think you've covered the full implications of significantly postponing death. Many people have strong objections to the idea that go beyond the "too many people" observation. So I suggest finding a sincere, articulate opponent to extending life, someone who is going to challenge you, on philosophical/environmental/spiritual grounds, on the longevity interventions that you (and I) are so fond of. Nathan Carey Nathan Carey 5 months ago Definite do a season 2, I’d love to hear more, particularly around diet and lifestyle, as well as how to actually measure or participate in tools that help those not in the US to gauge progress and if things are working. Those of us unable to measure are a bit stuck following your protocol, but I’m loving nmn, OMAD and Athletic greens right now! denise m denise m 5 months ago Love love love you guys! Finding good affordable resveratrol and NMN is vital. Amazon is full of crap and Thorne is too expensive. Berberine made my gut concrete- what can one do about this 🥰 M L M L 5 months ago I've been waiting for this podcast where you finally mention BioButton!! Excited to follow the company and eventually get my hands on these medical devices 😁 Please do continue with more episodes, there's so much good information in here 🤯 1 Matilde Bagnoli Matilde Bagnoli 5 months ago Please, do another season. The information you are sharing is extremely interesting. Please keep us up to date. I found the conversations about the ethic implications of biometric data collection most useful. Thank you. vonwolly2 vonwolly2 3 months ago Well I've said this before really like David Sinclair. I'm waiting for new videos. I do think probiotics from people in their 90s and centenarians and super centenarians. Might hold the key to better brain function. By studying the micro biome of people over 90 that have genius IQs are close to it. These nine-year-olds and super centenarians have had very little cognitive decline. This might not all be due to genetics it might be something in there micro biome that is passed down from her mother. We know the gut has a lot to do with brain activity now. The Japanese are studying this intently but they're not looking at Americans, Australians or British people to my knowledge. We might even be able to increase people's IQ by changing their micro biome certainly we can see this in autistic children to some degree. Maybe we can improve Cognition" regular people intelligence by improving their micro biome. Making them resistant to Alzheimer's maybe. Maybe there is some magical gut bacteria maybe there is some Centenary and that is a Superman/super human because of what is in his micro biome are her micro biome.. I think you can patent probiotics that's what the Japanese do it. My mother is on probiotics for her bone health and we've seen her bone hardness density increased quite a bit over a short period of time using Japanese patented probiotics. Amazing stuff. I apologize for the poor quality my writing just in a literate janitor hoping to help the world.Or maybe there is a combination of superbugs in the micro biome they can increase intelligence. Maybe these microorganisms have a synergistic effect they increase intelligence and therefore increase lifespan. It's been shown that people with higher IQs live longer statistically speaking. So maybe if the micro biome has some degree to do with intelligence maybe it will increase lifespan at the same time.If we can establish the centenarians IQs in their younger years we retest them in older age and there is very little decline. It might not just be genetics it might be something in the micro biome that is that is preserving their intelligence. A. H. A. H. 5 months ago Really hope you guys keep going. Really appreciate your Podcast. 1 bgroisma bgroisma 5 months ago Congratulations Dr. David Sinclair, Matthew LaPlante and team ! it was really wonderful, and like to add more content regarding microbioma, biofeedback with VO2max and stress measurements, cetons, etc. Bhushan Lokhande Bhushan Lokhande 5 months ago Thank you, Dr. David Sinclair and Matthew LaPlante. This series has been wonderful. It was enlightening to learn so much about the science around aging. From this series, I was able to take into account actionable lifestyle changes like the importance of sleep (following the Circadian clock), exercise, intermittent fasting, nutrition (focus on plant-based diet). Needless to say, the role of the chemicals was covered in in-depth (Metformin, NAD booster, Resveratrol) relevant to health and aging. This is an area where I don't have clarity on the course of action. I understand you are likely not able to give direct recommendations. However, this is an area where a listener like me is confused about how to proceed. The suggestion of talking to the doctor may not achieve much, especially if you don't have ongoing issues. Doing research or a buy based on reviews on Amazon is a likely option, but still, it does not provide much conviction if you are making the right decision with the product. Seriously looking for some help in this area. Another question: would you suggest an approach/process to introduce these supplements and monitor if there are any side effects, before incorporating them in long term. Looking forward to your guidance. 1 Johnnie Kemp Johnnie Kemp 5 months ago Dr. Sinclair and Matthew Laplante, Great podcast explaining the most exciting area of research: longevity and vitality! Very inspiring to all us biohackers who are embracing upleveling our health. Looking forward to season 2! Kate Noel Kate Noel 5 months ago I would love a season two. I am curious about peptides. I would love a series that went through the various body systems or broke out the information based on different age groups and what you should be focusing on. I look forward to this upcoming technology! Thank you for all hard work putting this informative and enjoyable video series. Kristin vc Kristin vc 5 months ago (edited) Just got my Oura ring yesterday and hoping to get a CGM soon. I find these devices so helpful. Thanks so much for this series- thoroughly enjoyed it and found it fascinating. Please continue! 1 Nick Middelton Nick Middelton 5 months ago @David Sinclair Thank you for sharing this incredible knowledge in your book, and this series. I very much hope you all make another season, and perhaps many more after that. Nicola Gordon Nicola Gordon 5 months ago wonderful- thank you- yes, i want more! yes, interested in menopause, which i'm in, cancer, which i had, life span stuff of course. so informative and hopeful- thank you!!!!!!!!! Explorers of the World Explorers of the World 5 months ago (edited) Thank you for very valuable and useful knowledge, I would be interested in the topic of fertility in women, how to care for it and whether it can be kept? 💝 1 David Kan David Kan 4 months ago I enjoyed the series thus far. Two topics I would like to see addressed: (1) increasing longevity in pets, especially dogs (2) philosophical implications of longevity. Is this another "immortality project" in our search to create meaning? Aicul Sunlight Aicul Sunlight 5 months ago Thank you Dr Sinclair and “lovely” co-host for all you do. I really appreciate it and I am hooked on your podcasts. Plz let me know where can I purchase the same NMN you have been taken . Thank you . Chris Almighty Chris Almighty 2 months ago We would love season two indeed. This is a game changing breakthrough O Sebastian O Sebastian 5 months ago Fantastic season 1 and looking forward to a season 2. You know; I been hooked on Health Summits for a very long time... Amigo, David consider doing a summit and /or a Documentary or docuseries. I have not felt the need to buy near-future technologies and or supplements because I live in a very remote area...Fortunately I have abundant access to nature and have unlimited access to natural ingredients... I'm about your age and plan to keep listening to you for the next 50+ years. 1 Lina AbouDheir Lina AbouDheir 5 months ago Honestly Dr David & Matt an amaaazing episode , lots of knowledge and research in the pipeline , I need to listen to it more & more 🥰yessss please more episodes Cannot have enough Best of luck in outcome of research Sooo lucky to be living I. This era & witness ( & try too ) what’s happening Sheridan Twice Sheridan Twice 3 months ago Thank you so much for your amazing job… I love this podcast !! God bless you!! smc5910 smc5910 5 months ago I look forward to another 50 years (at least) of new series. I enjoyed this past series tremendously and gain so much insight. I have to ask, is there any significance to the bracelets you both wear? Vijay Thapa Vijay Thapa 5 months ago An incredible podcast series. Here's fervently hoping for many more seasons. David Sinclair euan Mclaughlan euan Mclaughlan 5 months ago Loved these podcast, would love to here more about rapamycin, also the reprogramming I find fascinating. Thanks David and team 👍 Teresa Belcher Teresa Belcher 5 months ago Yes, I would love for you to do a season two. I have followed Dr. Sinclair for years. I want to thank you for your efforts and congrats on your success! Alicia B Alicia B 5 months ago Hoping for season 2. This first season has been brilliant. Thank you for the effort the team put into sharing actionable science with those of us who are not scientists. Looking forward to my first shipment of Athletic Greens. appl314 appl314 5 months ago Thank you for these podcasts. They are very helpful. I would like to see discussions of areas of improvements on osteoarthritis. If exercise is so important, there are many who need this one fix to move forward to better health and reduced overall hospital/medical costs over a life time. Dorota Go Dorota Go 12 days ago I enjoy and appreciate your podcast very much. Thank you for doing this pro bono. This way I can summarize takeaways to my parents who don’t know English, but should be informed about longevity lifestyle. And this is a pity that most of scientific news are in English and older people from non-English speaking countries cannot learn by themselves. Hopefully your book will be translated to many languages. Reg content of your podcasts, It is much to digest for a person without scientific background, so notes are really helpful. In season 2 You could talk more about best bio-available supplements and ingredients to watch out for. So many of them on the market… thanks! Marlene DeLaTorre Marlene DeLaTorre 5 months ago Loved every minute learned so much! Can not wait until your next podcasts! Soon As I hope..Thank you so much! Laurie Meunier Laurie Meunier 5 months ago Yes David more please! Thank you, Matt and your entire team. EdLanceinSD EdLanceinSD 5 months ago Yes please do season two! I did the inner age test, I would love for you to do an episode where you break down the inner age factors and what it means from your point of view. Heather Kosse Heather Kosse 5 months ago Love it. More episodes, please. Everything and anything regarding postmenopausal fitness/nutrition while also dealing with autoimmune issues such as Hashimoto's would be lovely. Yes, aging is one thing, but aging with ALL of the other issues can get super complex. Lilia Pandova Lilia Pandova 5 months ago Hello! Appreciate your work and please, do a season two. I'd love to see an episode about hormones, how they affect longevity and what we can do about it. Thanks! lover lover 5 months ago Thank you for your broad thoughtful conversation🙏 Knowledge is a true power🧠 1 amax1mov amax1mov 5 months ago Amazing podcast! I will be waiting for the second season Vladyslav Cherevkov Vladyslav Cherevkov 5 months ago Thank you so much for the amazing work!! Season 2 please with AMAs Would like to know about how most brands of NMN don’t actually have NMN when you test it because the molecule breaks down after 45 days. Would like to hear some reputable NMN brands as well as crystallized NMN Laurent Molteni Laurent Molteni 5 months ago Loved it! Please make more 😊 Question: I need a knee replacement. Should I wait for something coming on the market? Lorecivivint is still in trial, I an not sure it's the best solution. Thank you. Uriah Maynard Uriah Maynard 3 months ago Absolutely love this series and I hope to see another season. Micah Bratt Micah Bratt 5 months ago (edited) I thoroughly enjoyed your book David and appreciate everything you guys are doing in this space. Keep up the good work! C. M. C. M. 5 months ago Please do a season 2. I have learned many amazing things from your show! Definitely a must watch! Yasmin Abdelfattah Yasmin Abdelfattah 4 months ago Hi I have loved listening to all your podcasts! I have found them so informative and interesting. I was just wondering if you had any knowledge of company lifewave? They sell patches called 39x which are supposed to activate and mobilise the body’s steam cells which in turn would make you more youthful . Do you have any knowledge of this and it’s effectiveness?Any feed back would be great. I would love a season two…… Also in regards to inside tracker do you have to be living in the states to have the blood work done? Lene Lene 5 months ago Thank you so much for knowledge you have imparted to us! I learned many ways to improve my lifestyle. I will be looking forward for season 2. Nadia Palma Nadia Palma 4 months ago Really love this season and it would be great to continue the series. Perhaps bring in guest speakers too! honkingood honkingood 5 months ago Should definitely have a season 2! 1 Angie Damian Angie Damian 2 months ago Yes, thank you Dr. Sinclair, pls do more episodes and God bless you both. Eirini Stefanidou Eirini Stefanidou 5 months ago Do season 2, please!!! Really interesting and helpful. Thank you ! Sherry Ellesson Sherry Ellesson 5 months ago Wonderful series - I'm ready for the next, with updates on the things "scientists know that they don't tell everybody." Richard Adams Richard Adams 4 months ago Please do a 2nd season. I would love a deeper dive in brain health. Also the timing of supplements. What works best when taken in the morning and evening. TY. Cheers. Peter Snelling Peter Snelling 5 months ago Loved this! I truly hope you do another series that offers current solutions to help us make it to the miracle ! Alex Ho Alex Ho 5 months ago Well done both! Would love to get more on this. Also been subbing your Patreon. Keep goin! Amanda Sanders Amanda Sanders 3 months ago Yes to season two!!! I think we need daily podcasts from you two. Absolutely life changing and I’m so deeply appreciative of the time and passion that you’ve dedicated to this cause. Thank you and can’t wait for more! IG:curtisinhouston IG:curtisinhouston 5 months ago Really great series, I just hope the predictions age well 🧬🧬🧬 David and Matt have a wonderful rapport that make the videos entertaining as well as informational. And for free! I listened to the audiobook and was happy it was read by Dr. Sinclair. Highly recommend for anyone interested in these subjects. The book goes much more into depth and is helped along by David's knack for telling a story and using analogies from everyday life to break down complex ideas. Because of this podcast I finally decided to try out Athletic Greens and really wish I had started earlier. Worth it. Looking forward to another series, thanks guys! 1 Savannah Joy Savannah Joy 3 months ago I appreciate you guys making this podcast so much more than you can know. You have empowered me to heal myself and my loved ones. Thank you. In a future episode I hope you will cover female specific health. Looking forward to a second season (: perkyzombie perkyzombie 5 months ago Absolutely fantastic series ! I was largely missing the supplements. I started NMN, Resveratrol, and Quercetin because of this series. In the first week of NMN my running started improving, I attained new peaks in VO2 max, a decrease in max heart rate at hypoxia, and a new record for fastest pace. Beyond that I feel just fantastic. More so, I'm guessing, the Resveratrol and Quercetin morningly in olive oil; my bad knee, my lower neck pain, it's nearly completely gone after two weeks. I've lived with this worn-out body pain so long I can't remember not having it; I feel fantastic. Thank-you both and all the support staff, this is healthcare. Your book is excellent and I look forward to listening to future discussions. God bless. 1 Laura Macaddino Laura Macaddino 5 months ago Would love a season 2!! I am very interested in whether there is any information on how pregnancy/child-bearing affects longevity. TheThrillerZone TheThrillerZone 5 months ago My wife and I discovered this show while traveling cross country and since then I haven’t missed an episode. PLEASE do a second season. Your info is invaluable, you make the complex understandable, and it’s simply amazing. I for one (at 63) want to surpass 100 but only in strong health. Seriously, this is among the best podcasts out there. And trust me I host 2. Cheers. SwagDtrain357 SwagDtrain357 5 months ago Im leaving my mark here for when aging gets cured and this guy gets famous 1 Shawna Asendorf Shawna Asendorf 5 months ago Thanks, I’ve learned so much. I have your book and will now dive into that and would love a season 2. MrEtc31265 MrEtc31265 5 months ago (edited) I am would really like to see a future series (tomorrow). Thank you. I would like to see deep dives into: Women's Health Protocol Greg Fahy, Gene Therapy Thymus Rejuvenation Intervene Immune Gene Therapy Stem Cell Therapy • Round of Senolytics (Dasatinib + Quectintin + Fisetin) • Neupogen Ozone Therapy Nasal / Mouth / Ear Health 2 SIXX SIXX 5 months ago Love what you do? That's an understatement. I followed every word you both said. Thank you for this season! Season two...yes please! Angela Weitzel Angela Weitzel 11 days ago I learned a lot in the series and beg you to please do another season. Thank you for sharing this great information, now I'm not only taking the supplements, but also exercising and taking care of what I eat. Thank you guys for helping us improve our lives. Looking forward to the second season. Andy Friedl Andy Friedl 5 months ago Definitely do a season 2! Blood glucose tracking sounds interesting. Also a deeper dive into HBOT, sauna, cryo therapies would be great! And blood plasma dilution... Albumin/ saline mixture- how that affects blood aging biomarkers Sebastian Tysler Sebastian Tysler 5 months ago (edited) For the future episodes I think it would be interesting to hear about glycation and AGEs (advanced glycation end-products). Apparently high levels of AGEs are associated with premature aging and resveratrol can reduce negative effects of AGEs. 1 Roxana Grecu Roxana Grecu 5 months ago Awesome podcast! We definitely need a Season 2! Please offer more information on fertility! 1 Christie Dessy Christie Dessy 2 months ago Dr. Sinclair and Matt - We are hungry for more - I have been interested in the "fountain of youth" since I was a teenager - and now into my 70's. Keep asking the right questions ! Yes to season two. Trina Kling Trina Kling 3 months ago I really love this series!! Please do a season 2 and many more after that! Otto van Bommel Otto van Bommel 4 months ago Keep it up David and team!!!! Hopefully, we could also change the vision of lawmakers on social and economic inequality. In so building a better future for humanity. Gyopárka Oprea Gyopárka Oprea 5 months ago Thank you so much for this series and also for making it available for free! Please continue this amazing work and keep educating us also. Among other topics I would love to learn more about aging in relation to pregnancy and the number of pregnancies, aging and the effects of breastfeeding, hormonal contraception and aging, child nutrition and healthy life setup for children. Thank you! I am watching each episode again and reviewing the notes I took. Cloudy2 Cloudy2 4 months ago (edited) Thank you Dr Sinclair for your podcasts. There is a minefield of supplements (supplements you take) that could be low quality or even harmful with only a label touting resveratrol or NMN, for example. How should we select the right manufacturers/brands? Mark Voelker Mark Voelker 5 months ago Thank you for these podcasts, and for the work you are doing. You asked what I am interested in. Three things: 1) Practical developments that I can expect to apply to myself in the next few years (I am 66), 2) How to combine life extension and age reversal with bodybuilding (If that is possible), and 3) The issue of privacy and respect for the rights of the individual. The last subject is very worrisome for me. "Big Tech" has demonstrated a pronounced tendency toward authoritarianism, and I do not want to live in a world where access to these life enhancing technologies is dependent on me obeying government or corporate masters. The behavior of governments and large corporations during this pandemic, including censorship, medical mandates, and lockdowns, has shown that these organizations do not respect human rights, and indeed will use the powers inherent in big data and advanced medicine, to impose political tyranny. A world where access to rejuvenation technology is dependent on obeying political and corporate rulers, is a dystopia, not a utopia. Anon Anon 6 days ago I can tell David's brain is operating at an extremely high level. He's faster and, downright younger, than your average 50 year old. Can tell this just by hearing him talk, it's remarkable. M V-H M V-H 5 months ago Season 2 please!! Conversations about cholesterol, more about skin and hair, good and not so good-return for your money supplements. Great season!! Paula Ukena Paula Ukena 5 months ago MORE PLEASE !!!!!!!!!! THANK YOU SO MUCH ☺️ I am learning so much. Would love to learn more about menopause if soy is helpful in cream form for skin and also if it’s beneficial in edible form? Joe Anarumo Joe Anarumo 5 months ago Thank you for doing this. My attention has widely shifted to better understanding longevity and what I can do to enjoy longevity. I very much hope you choose to make a season 2, as it would be nice to learn about the changes that are always happening. Sylvie Ssk Sylvie Ssk 4 months ago D'day David. Congrats on your podcast, excellent thank you. I'm old and have been taking NMN and resveratrol for 2 years now. Love Lifespan book. Please touch on blood groups and anti aging supplements i.e NMN etc. Thank you omarvalle69 omarvalle69 5 months ago Fantastic material!! Please do another season! There is so much misinformation out there you podcast is like a light in a dark scary tunnel :) Usman Sarfraz Usman Sarfraz 5 months ago Love it ! Keep it up. +1 on the fertility as one of the topics to be included in the future podcasts in reference to the longevity and people having kids later in their careers. 1 Jen Dunham Jen Dunham 1 month ago Loved listening to this podcast. Definitely do a season 2...keep us up to date on all the many new technologies/supplements etc. rapidly being developed and how the average person can benefit. Thank you guys... 🦇 𝖆_𝖖 🦇 🦇 𝖆_𝖖 🦇 2 weeks ago Hello sir@drdavidsinclair, i am very interested in anti aging research and the work you are doing in this field. Although i don't hold a medical degree of any kind, but is there any way i can contribute to your work or become an associate in your foundation/lab ? Christopher Hernandez Christopher Hernandez 5 months ago Absolutely a season two! This information is transformative. Linda Walker Linda Walker 5 months ago Yes!…for a Season 2! Am at age 72, in good health, no prescription drugs, weight appropriate, and active. Healthy brain is my primary health concern as I see friends, my age and older, suffering from debilitating memory loss. Also, I would enjoy looking better. My order of NMN and Resveratrol just arrived yesterday. And so it begins. An episode I’d love to see would be about what those in their 70s and 80s could benefit the most from, assuming overall good health to begin with, in the way of supplements, maybe prescriptions, and best monitoring info for going forward. Also, it was challenging to chose the NMN and Rservatrol products. As a layperson, knowing what to look for and which ones to purchase is a big learning curve. Some additional help in this area would be appreciated? Am not afraid of dying. Just want to have a good quality of life while I’m here as well as not being a burden to my children and grands. Being productive and supportive for my family and community is the very best I can strive for. Thank you so much Dr. Sinclair and Matt for this series of 8 remarkable videos. I applaud you both and so appreciate the wonderful up-to-date research and results. Kudos!!! Nikita Golubev Nikita Golubev 2 months ago Please, do a seson 2. I really need to have the proven data on what parameters put most attention to. Since, monitoring is not that well developed and a What's Real, What Works: Effective anti-aging and skin care solutions 3,160 viewsDec 28, 2011 Penn Medicine 47.7K subscribers Ivona Percec, MD, PhD, a plastic surgeon at Penn Medicine, discusses surgical and non-surgical anti-aging interventions available to help you look and feel your best. 1 Comment rongmaw lin Add a comment... TRAFFIC STRINGS TRAFFIC STRINGS 7 years ago V-am vazut intr-un reportaj pe discovery science felicitari , este absolut extraordinar ceea ce faceti in cercetarile Dvs, "These Habits DESTROY Your Health & Decrease Lifespan!" | Dr. David Sinclair 36,002 viewsJul 29, 2022 1.4K DISLIKE SHARE DOWNLOAD THANKS CLIP SAVE Lewis Howes 2.34M subscribers Download podcast episodes a week early here! - http://www.lewishowes.com/pod 116 Comments rongmaw lin Add a comment... Bernadette Jean-Marie Bernadette Jean-Marie 10 days ago Lewis you always seem to ask the questions I am thinking about and other really interesting ones. Thank you so much for your amazing guests. 21 Lewis Howes · LEARN FROM LIFE. LEARN FROM LIFE. 10 days ago Being a new youtuber i would love to say these podcast educates and make you self aware literally what you don't learn from books we learn from such great amazing personalities,you make us self aware thankyou so much keep blushing and keep glowing 29 Lewis Howes · Tracey Leigh 1111 Tracey Leigh 1111 5 days ago Thanks for this Lewis. I love that you get all the information needed and don't squeeze things into a 30 min chat. I have followed David for a while now and have read his book. The hardest thing (almost impossible) is finding quality resveratrol in Australia (ironically) or knowing what are the best brands to order from overseas. It's trial and error but a big waste of money at times. I hope Australian companies get it sorted soon. If anyone can recommend any they trust it would be appreciated. Truly grateful for your greatness Lewis. 🙏 A long time fan 💚 5 Lewis Howes · Natalie Axl Natalie Axl 10 days ago Dr, Sinclair is the best!! Wish he did more podcasts 🙏❤ 24 Kenz300 x Kenz300 x 10 days ago (edited) Exercise reduces stress and improves cardiovascular health. Every adult and child should own a bicycle and ride it regularly. Ride to work, ride to school or ride for fun. A bicycle should be your first choice for short distance travel. Getting children and adults away from computer screens and on to a bicycle would improve health and longevity. 11 Evelyn Karkkulainen Evelyn Karkkulainen 8 days ago Thanks, Lewis, for always giving us the best guests and asking the fascinating questions that help us to improve daily. 3 Lewis Howes · Esther Jaedi Esther Jaedi 8 days ago Enjoyed listening to this discussion with fascinating questions and answers to health, longevity and science. So much positivity to enjoy 😉 life, instead of consuming negativity with the mind set. Thank you for sharing the wisdom n knowledge 4 Lewis Howes · Shameemah Jahed Shameemah Jahed 4 days ago (edited) Lewis you keep getting better and better! Stay blessed. And you haven't aged becuase of your heart, your authenticity and love for people. We appreciate you! 1 Lewis Howes · JollyMolly Ramram JollyMolly Ramram 4 days ago Very interesting interview he certainly has a lot of knowledge that was great listening to👌 I wish they had talked about mental health and how your emotions can change you on a cellular level too it’s not all about what you eat and avoid Roger Bruce Roger Bruce 6 days ago Always love watching interviews with Dr. Sinclair. Hoping at my age I will make it another 5 to 10 years. 2 Lewis Howes · The Bearded Rooster The Bearded Rooster 1 day ago Lewis, your channel is one of the best on the internet. Great for wealth, health and happiness.. Much respect brother. 1 Lewis Howes · stephanie stephanie 1 day ago Sugar substitutes (including stevia) were recently found to have the same impact on glucose and insulin spikes, but a delayed reaction, (2 hours rather than 30 minutes) and that over a 24 hour period, actually contributed to a higher average glucose level, due to excess consumption resulting from increased cravings and reduced satisfaction, while the misconception that sugar substitutes are inert also contributes to overconsumption. 1 Esther McGough Esther McGough 10 days ago My exercise is walking and working . At work im on my feet 99% of the time. 9 Rosemarie Rosemarie 10 days ago I’m 66 years old female and I lift weights twice a week, do High intensity in a treadmill also twice a week and I do a moderate walk for 30 minutes once a week. I also do intermitting fasting (16) hours My diet is extremely healthy. Love olive oil being from Spain I grew up with it. Is all about life style. 11 Olivier Liengme Olivier Liengme 10 days ago (edited) What if the question be more like live better instead of live longer ? 9 Julia Stantic Julia Stantic 2 days ago I would like if David shares one example of his evening meal. Thank you in advance. 2 Sharmin Proctor Sharmin Proctor 10 days ago Concerning glucose levels Isn't it depending on what you eat.. and of course when you don't put food in ..it won't spike.. Also skipping breakfast that is the worst meal to skip .. You don't eat all night so your body would need water and nutrients in the morning .. assuming you do not eat late into night ...where you wouldn't be hungry next day... And it's so good to eat your meal so digestion is complete before you go to sleep..then your body and digestive system can rest and your body can repair while you rest...as you go to bed early 9 or 10 pm I eat 2 meals every day..one in morning and one at 3pm... as a rule your body needs about 4 hours to digest your meal and 1 to rest... before your next meal.. Alcohol in any amount is not healthy .. you can get the nutrients from grape juice and avoid the dangers of liver damage, blood cancer, throat cancer etc.. Even in small amounts wine's can be hazardous, it may take longer if you you do stick to one glass but many do not! Love intensity training! 6 Danny Gee Danny Gee 10 days ago Hope everybody that see this live a healthy and joyful life 5 Lewis Howes · Tyson Tyson 5 hours ago Your content is amazing! I'm surprised you don't have more likes and subs! All the best to you and thanks for these great videos! Linda Ngadiman Linda Ngadiman 10 days ago I love you guys...thank you so much for always sharing LIFE to the world. I am too want to live longer🙏 Thank you again. 2 Lewis Howes · Ann Lynch Ann Lynch 10 days ago This was a fantastic show. I learned new things to improve my life! 3 Lewis Howes · seventhwave seventhwave 7 days ago Lewis, I love all your interviews. So informative and empowering. Can you please interview Gabor Mate? It would be so interesting! 🙏🙏🙏 Lewis Howes · Esther McGough Esther McGough 10 days ago (edited) My meat based WOE is doing great things for me. I do add veggies. Broccoli, spinach, simetime carrot, bell peppers, onions but not everyday. Have lost 90 lbs eating this way over the last three years 2 months. Im 63. Yes I do look younger than that. Not on any meds. My Dr. Loves all my tests. I do timed eating at least 5 days a week. Fasting min. Is 12-16 hrs a day again at least 5 days a week. I feel like im doing great. My WOE keto with carnivore days no cheat days but keto treats ocassionally 3 森之阳 森之阳 7 days ago Love every interview. As a Chinese, I watch the videos at .75 speed in order to understand the contents better. 😂😂😂 1 Lewis Howes · That Chess Guy That Chess Guy 11 hours ago (edited) I have a rule that I don’t eat until after 1pm, but I don’t have a rule for when I start eating. Sometimes it’s 1:30, other times it’s 5:00 pm. Is this variance unhealthy or is the slight irregular healthier? @1:49:15 100s of years? I’d give it 100 tops. We already have a chip in pigs brains. Also are these a bunch of different interviews pasted together? Quintin Lemon Quintin Lemon 10 minutes ago (edited) Wouldn't it be wonderful if we could live a good old healthy life. They are.!! there is a village where there's a lot of 100 + year old folks..living loving and laughing 🌟 Palmer Yates Palmer Yates 10 days ago Enjoying the vast information so far.. ❤️❤️❤️ from Ghana 🇬🇭 6 Lewis Howes · mikapuk mikapuk 10 days ago Could someone sum up those keypoints? 6 avert thy mortal eyes avert thy mortal eyes 10 days ago (edited) I eat once day and I feel great. When I do eat I make sure to include the 3 macronutrients your body needs. Fat, protein and carbs. Food is sustance only. We need to move on from foodie culture. Its gluttony. 4 vmaniscool vmaniscool 7 days ago I’ve noticed that listening to your body it will tell you exactly what you need to eat 1 Adele Adams Adele Adams 8 days ago Please add the year for each separate interview! 1 Roger Bruce Roger Bruce 6 days ago Where is that backup drive? I need to turn it on :) Does Dr. Sinclair have a check list of how to turn on these longevity genes? i need some details. I don't smoke, drink, but have asthma, diabetes and sleep apnea. I want to do this safely so any specific help and ideas with meal planning, etc will be helpful. Mia LaMarca Mia LaMarca 4 days ago Minute 220! Finally, the brilliant Dr Sinclair mentions the true possibility…. “wall-E” 😳😳😳😳 Melissa Christie Melissa Christie 8 days ago Fascinating! Let stress less!! 1 Lewis Howes · Nancy Swift Nancy Swift 10 days ago Thank You for the Information. Enjoy your day. 1 Lewis Howes · GEM TWIZM GEM TWIZM 10 days ago Pure Heart=Pure life 3 Sam Yangkam Sam Yangkam 10 days ago Thank you for this. 🙏 5 Lewis Howes · Lee Rogers Lee Rogers 9 days ago I love your work! And.... l rarely get sick also. 2 Danny Medina Danny Medina 10 days ago SO AMAZING 5 Lewis Howes · Monica Latvenas Monica Latvenas 9 days ago Lewis has a baby face <3 3 Donna Strong Donna Strong 9 days ago Love all this positivity how about can you cure deafness and severe tinnitus and severe Pulsatile and severe Hyperacusis? 2 Vicki Bazter Vicki Bazter 10 days ago EAT THE COLORS 8 Jmack1lla Jmack1lla 9 days ago Hell yeah dude 2 Lewis Howes · Nikki Nounou Nikki Nounou 10 days ago I tried eating one meal a day, I lost weight and because I was already slim 1 Peter Grace Peter Grace 10 days ago I want to look young forever. 2 Ben Tam Ben Tam 7 days ago Excellent material Lewis Howes · G Y G Y 10 days ago When was this interview please? Thank you 1 Kerry Hopkins Kerry Hopkins 7 days ago What did he say “roseydol?” Anyone catch that plant supplement please? Юрий Ханин Юрий Ханин 10 days ago Here I am))) Stay save 😄 1 April Michael April Michael 10 days ago Red wine. Oh my red wine..need I say more???😅😅💓 3 Lucius Bradæn Johansson Lucius Bradæn Johansson 8 days ago No summary yet? 1 B Marie B Marie 10 days ago But what's considered a big meal to this guy!!? 1 #Better #Health #Wellness Anti-Aging Scientific BREAKTHROUGH! | BETTER! with Dr. Stephanie & Dr. Kara Fitzgerald 773 viewsPremiered Jul 3, 2022 32 DISLIKE SHARE DOWNLOAD CLIP SAVE Dr. Stephanie Estima 3.34K subscribers In this episode, Dr. Stephanie interviews Dr. Kara Fitzgerald, one of the leading experts and clinical researchers on DNA methylome and its influence on Aging. They do a deep dive on her most recent study and it’s conclusions. They talk about the scientific race towards immortality, funded by billionaire tech giants and large governing bodies. You’ll learn how your genetics can be influenced by your previous generations, and how you can change the direction of your genes. Lifestyle. Diet, and stress management are key factors for a long life, but the science is getting more and more advanced. We wrap up this week’s podcast with a chat about Kara’s recent introduction to motherhood, and her sentimental scientific discovery for non-biological parents like herself. What a great guest to have on the Better show, and we look forward to chatting with her again in the future! Welcome to BETTER! With Dr. Stephanie This show is for high performing women who want to have BETTER bodies, BETTER minds, BETTER relationships, BETTER sex, and BETTER families. I love taking complex science and making it easy to integrate into daily life. *WE’D LIKE TO THANK OUR SPONSORS* Athletic Greens - redeem an exclusive offer here: https://www.athleticgreens.com/stepha... LMNT - An electrolyte drink mix with everything you need & nothing you don’t. http://drinklmnt.com/DrEstima BiOptimizers - unique health solutions to optimize body, mind, & soul. http://bioptimizers.com/drstephanie Orion Red Light Therapy - get 10% off your order with Promo Code “STEPHANIE10” https://www.orionrlt.ca/?ref=Stephanie Lumen - get $25 off your order with Promo Code “DRSTEPHANIE25" https://www.lumen.me/?fid=1799 Ancestral Supplements - Use Promo Code “ASA10” for 10% off any purchase https://shop.ancestralsupplements.com Some of the links above are affiliates which means that making a purchase through them won’t cost you anything - in fact, you get a discount for being a valued listener to the Better! Podcast. We do receive a small commission. This is an easy, free way of supporting the podcast and we thank you for that! *TO JOIN OUR FREE COMMUNITY* For special bonus episodes, show transcripts, and more, you can join our free inner circle here: https://hellobetty.club/ *TO FOLLOW DR. STEPHANIE ON SOCIAL MEDIA* Instagram: https://www.instagram.com/dr.stephani... Facebook: https://www.facebook.com/groups/bette... LinkedIn: https://www.linkedin.com/in/drstephanie/ *YOU CAN ALSO LISTEN AT* Apple: https://podcasts.apple.com/ca/podcast... Spotify: https://open.spotify.com/show/1YQS0V0... All Others: https://plinkhq.com/i/1553695927?to=page Get yourself a copy of my best-selling book, The Betty Body: https://bettybodybook.com #Better #Health #Wellness #Women #Podcast #BetterPodcast #HelloBetty #DrStephanie *YOU CAN ALSO LISTEN AT* Apple: https://podcasts.apple.com/ca/podcast... Spotify: https://open.spotify.com/show/1YQS0V0... All Others: https://plinkhq.com/i/1553695927?to=page Get yourself a copy of my best-selling book, The Betty Body: https://bettybodybook.com Dr. Kara Fitzgerald Links: Book: Younger You Podcast: https://open.spotify.com/show/1Lrl3pD... Website: https://youngeryouprogram.com/ App: 3yy 4 Comments rongmaw lin Add a comment... Megan Wildhood Megan Wildhood 3 weeks ago I totally agree that the push for immortality is incredibly immature and ego-driven. I really appreciate that being called out! Additionally, does anyone else find it very confusing that the same people investing in manmade immortality (which I find terrifying to be honest; the only thing scarier than dying is not dying and we already have millions of people struggling with the purpose of meaning of life) are also publicly hand wringing that there are too many people? Who gets to decide who's "extra"? Who gets to decide who lives forever? It will likely be decided along class lines. In the pretty near future, poor people will die and the rich will live forever. God forbid (not sarcasm). Petra Versteegh Petra Versteegh 1 month ago Aaaawesome tnx!!!!