Gut Microbiome in Health and Disease ,UCSF Department of Medicine

Our Emerging Understanding of the Gut Microbiome in Health and Disease 21,967 viewsDec 13, 2021 UCSF Department of Medicine 7.21K subscribers In this UCSF Medicine Grand Rounds, we will explore the latest innovations surrounding the gut microbiome, including its key role in maintaining our general health and how it goes awry in inflammatory bowel diseases. Dr. Susan Lynch, Professor of Medicine in the Division of Gastroenterology and Director, Benioff Center for Microbiome Medicine, and Dr. Najwa El-Nachef, gastroenterologist at UCSF Health and Program Director of the Gastroenterology Fellowship, will outline the latest developments in the field of human microbiome research for prediction, prevention, and treatment of disease. We will also discuss the latest data on how fecal transplants have changed the management of inflammatory bowel disease and other disorders. Note: Closed captions will be available within 48-72 hours after posting. Program Bob Wachter: Introduction 00:02:59-00:30:32 – Sue Lynch (UCSF Professor of Medicine in the Division of Gastroenterology and Director of the Benioff Center for Microbiome Medicine) 00:30:32-00:47:34 – Najwa El-Nachef (gastroenterologist at UCSF Health and Program Director of the Gastroenterology Fellowship) 00:47:34-01:01:09 – Q & A Bob Wachter: Closing See previous Medical Grand Rounds: • December 2: The Omicron Variant and the New Antivirals: How Much Will These Change the Pandemic in 2022? https://www.youtube.com/watch?v=IQL-t... • November 18: In Conversation with Mark Laret https://youtu.be/804WTkCu63s • November 4: Covid-19 — Update on Vaccines and The State of the Pandemic with Paul Offit and George Rutherford https://youtu.be/3fj3rJXzesg • October 28: Clinical Problem Solving https://youtu.be/KkaTPgha6R8 See all UCSF Covid-19 grand rounds, which have been viewed over 3M times, here: https://medicine.ucsf.edu/covid-19-ne... 18 Comments rongmaw lin Add a comment... Blake P Blake P 7 months ago I would selfishly love to hear a discussion from your GI specialists regarding SIBO, IMO, SIFO and other intestinal bacteria, archaea, fungal overgrowth diagnosis and treatments. I know this is an emerging area of GI that used to all be called IBS but are now being better understood, diagnosed and treated. My 7 y/o daughter has suffered with this and I didn't even know it existed 6 months ago but have been working my hardest to become more knowledgeable to help her through her treatments working toward a potential cure. Thank you for your consideration. 9 keely nelson keely nelson 7 months ago Fascinating, thank you. Patient and social media moderator for a large health care worker group. As a now healthy celiac, I have now begun to look at possible correlations between hEDS, POTS, MCAS, MTHFR genetic mutation, Marfan’s, and heart disease. Will be curious to see if there are ties to connective tissue disease & disorders. 4 Dr. Wezi Sunkutu MD Dr. Wezi Sunkutu MD 6 months ago Interesting research going on there. I salute. 2 keely nelson keely nelson 7 months ago As a healthy celiac, will be interested to learn if any correlations to diseases or disorders with correlations to connective tissue conditions such as hEDS, POTS, MTHFR genetic mutation, MCAS, Marfan’s, cardiomyopathy, Dysautonomia, etc.. 3 Steve Austin Steve Austin 2 months ago I read that bacteriophage behavior is observed in SARS CoV2 virus. I would love to hear more about this from these experts. Hugh Jones Hugh Jones 5 months ago Fascinating! Thank you! MAS DEATHBOXAR MAS DEATHBOXAR 5 months ago This is the cutting edge. We not taught these things in school until college. Tragic.... Rahul Naasha Rahul Naasha 7 days ago Will fecal improve ibs? BamBamBatMan BamBamBatMan 7 months ago 🍀 Go Irish . Kate Paine Kate Paine 3 months ago This is getting so far away from the natural to talking among yourselves with bum line of ego and money Abu Bakar Bin Khalid Khalid Abu Bakar Bin Khalid Khalid 5 months ago Phrophet Muhammad PBAH has talked about colon health 1400 years ago Personalized Nutrition: Microbiome, Mediterranean, and More with Christopher Gardner 10,285 viewsNov 16, 2021 LIKE DISLIKE SHARE DOWNLOAD CLIP SAVE Stanford Alumni 39.9K subscribers A surge of new companies are promising to help you find your personalized, optimal diet – if you will provide them with your blood/poop/spit/DNA and $$. Is it worth it, or should we just focus on: Eat Food, Not Too Much, Mostly Plants? Nutrition scientist Christopher Gardner will address the possibilities and challenges of personalized nutrition with an engaging blend of humor and evidenced-based science. Christopher Gardner, the Rehnborg Farquhar Chair of Medicine and director of nutrition studies at the Stanford Prevention Research Center. Professor Gardner’s research is focused on investigating the potential health benefits of various dietary components or food patterns, which have been explored in the context of randomized controlled trials. His long-term vision in this area is to help create a world-class Stanford Food Systems Initiative and build on the idea that Stanford is uniquely positioned geographically, culturally, and academically, to address national and global crises in the areas of obesity and diabetes that are directly related to our broken food systems. This talk was recorded at Stanford Reunion 2021. Featured playlist 13 videos 2021 REUNION CLASSES WITHOUT QUIZZES Stanford Alumni 15 Comments rongmaw lin Add a comment... Joe Smith Joe Smith 3 months ago I'm pretty impressed by this doctor after watching a few videos, as I am WFPB and he turned up in one of my searches. He seems like a positive teacher at least on the surface, in his presentations I have seen. He has a sophisticated, nuanced response to criticism and queries. California, and the world are lucky to have him and his big brain working on these problems. I know you are all 'pretending' that keto is 'healthy' in an attempt to unite a instigate change for the good. Sure it met your particular measures in this study but population studies are clear that excess saturated fat, especially the huge amount in keto, is a death sentence compared to plant based diets. 3 Marianne Schroeder Marianne Schroeder 3 months ago I am a dietitian that works in an outpatient setting. I came to Dr. Gardner's foundational diet conclusion a few years ago and focus on this with a majority of my patients. It feels incredibly validating to hear someone of his status come to the same conclusion. He has the data to back this up, which makes my life a lot easier! 2 Lise Marcell Lise Marcell 6 months ago Fascinating information! I have been a ZOE participant for almost a year now but I'm also taking an online course called the Soil Food Web by Elaine Ingham. It's all about regenerative agriculture and making bio active complete compost. The parallels between the soil food web and human microbiome are fascinating! When Gardner was talking about the fiber vs fermented food study I suddenly remembered a study from the soils course where they quantified plant growth as a factor of various things: Nitrogen, Phosphorous, Calcium, Magnesium, even Organic matter. Nothing tracked until they looked at Fungal: Bacterial ratios and then it tracked perfectly! (Soils which contain a diversity of microbes including bacteria, fungi, protozoa, microarthropods and nematodes create a food web which in turn creates optimal nutrient cycling for the plant). Your fiber vs fermented foods study also caught my attention because all of my scores in ZOE were quite poor and I suffer from fructose malabsorption, so eating lots of high fiber foods and/or prebiotics usually causes me distress. I'm guessing if I were to try the high fiber I would be one of the people with increased inflammatory markers. So I'm going to try increasing probiotics for a while and then gradually see how much of the prebiotics I can tolerate. Thanks for an inspiring talk! 3 Jane Haefner Jane Haefner 4 months ago Thank you for a very informative and entertaining lecture. Can you talk more about the lectin aspect of plant foods in relation to inflammation and gut health? Thank you for sharing your work on YouTube. 1 Sing4TheMoments Sing4TheMoments 6 months ago I love Gardner 💙🙌 not sure why he’s wearing a mask when he’s over 2 metre apart from others? 4 bainsk8 bainsk8 1 month ago What were the 19 inflammatory proteins that decreased please? I'm aware IL-6 was one but it would be nice to know the others. I have a personal interest in IL-17 N Day N Day 4 months ago 👍🏻 Gabriele Kennedy Gabriele Kennedy 4 months ago Love Christopher but the mask is silly. 1 STOKES REAL ESTATE STOKES REAL ESTATE 7 days ago Dude owns one shirt… STOKES REAL ESTATE STOKES REAL ESTATE 7 days ago It’s Stanford… Dr. Justin Sonnenburg: How to Build, Maintain & Repair Gut Health | Huberman Lab Podcast #62 558,899 viewsMar 7, 2022 13K DISLIKE SHARE DOWNLOAD THANKS CLIP SAVE Andrew Huberman 1.25M subscribers My guest this episode is Dr. Justin Sonnenburg, Professor of Microbiology & Immunology at Stanford University. Dr. Sonnenburg’s research focuses on how microbes in our gut impact our mental and physical health and how diet and your environment shape your gut microbiome. We discuss the architecture of the gut microbiome and microbiota variability in different regions of the gastrointestinal (GI) tract and how these can change in response to diet, environment or genetics. We explore the early establishment of your microbiome and how your mode of delivery into the world (C-section or not) shapes your gut. We also discuss lifestyle factors that can alter your microbiome and the integral role the gut microbiome plays in communicating to other organs, including your brain. Dr. Sonnenburg details his recent clinical study, which found that diets rich in fermented foods (but not fiber) increase microbiota diversity and reduce signals of inflammation. Additionally, we examine how foods typical in Western Diets (e.g., high fat, low fiber, processed foods) can negatively impact the gut microbiome. Throughout the episode, we discuss actionable tools from peer-reviewed clinical findings that anyone can implement, regardless of budget, in order to optimize their gut microbiome and health. #HubermanLab #Microbiome #GutHealth Thank you to our sponsors: AG1 (Athletic Greens): https://athleticgreens.com/huberman ROKA: https://roka.com - code "huberman" Helix Sleep: https://helixsleep.com/huberman See Andrew Huberman Live: The Brain Body Contract Tuesday, May 17th: Seattle, WA Wednesday, May 18th: Portland, OR https://hubermanlab.com/tour - code: ‘huberman’ Pre-sale tickets go on sale on Tuesday, March 8th at 10 AM PT Our Patreon page: https://www.patreon.com/andrewhuberman Supplements from Thorne: https://www.thorne.com/u/huberman Social & Website: Instagram - https://www.instagram.com/hubermanlab Twitter - https://twitter.com/hubermanlab Facebook - https://www.facebook.com/hubermanlab Website - https://hubermanlab.com Newsletter - https://hubermanlab.com/neural-network Dr. Justin Sonnenburg Links: Center for Microbiome Studies: https://stanford.io/3vGkdS0 Dr. Sonnenburg’s Lab: https://sonnenburglab.stanford.edu Dr. Sonnenburg’s Published Work: https://stanford.io/3HN6eMF Article Links: "Gut-microbiota-targeted diets modulate human immune status": https://bit.ly/3sLv2QI Book Links: "The Good Gut: Taking Control of Your Weight, Your Mood, and Your Long-Term Health": https://amzn.to/35RQP0c "The 4-Hour Chef: The Simple Path to Cooking Like a Pro, Learning Anything and Living the Good Life": https://amzn.to/3hqxkP0 Other Links: NIH Human Microbiome Project: https://hmpdacc.org Timestamps: 00:00:00 Dr. Justin Sonnenburg, Gut Microbiome 00:02:55 The Brain Body Contract 00:04:16 AG1 (Athletic Greens), ROKA, Helix Sleep 00:08:30 What is the Gut Microbiome? 00:12:49 Gastrointestinal (GI) Tract & Microbiota Variability 00:16:00 Breast Feeding, C-Sections & Pets 00:21:56 The Human Microbiome Project at Stanford 00:26:30 Traditional vs. Industrialized Populations 00:28:58 Resilience of the Microbiome 00:35:10 Regional Differences Along Your GI Tract 00:42:04 Fasting, Cleanses & Gut Health 00:51:19 Dietary Differences 01:01:24 Simple vs. Complex Carbohydrates, Processed Foods 01:07:03 Artificial & Plant-based Sweeteners 01:12:44 Cleanses: Useful? Harmful? 01:14:50 Your Microbiome & Your Immune System 01:20:17 Dietary Fiber & Fermented Foods 01:32:13 High-Fiber vs. High-Fermented Diet; Inflammation 01:41:33 Ripple Effects of a Healthy Diet 01:45:00 Does a High-Fiber Diet Make Inflammation Worse? 01:47:22 Over Sterilized Environments 01:50:15 The Gut Microbiome’s Effect on Physiology 01:56:45 Gut-Brain Connection 01:59:30 Probiotics: Benefits & Risks 02:04:20 Prebiotics: Essential? 02:07:00 Tools for Enhancing Your Gut Microbiota 02:11:12 Dr. Sonnenburg’s Research, Zero-Cost Support, YouTube, Spotify, Apple Reviews, Sponsors, Patreon, Thorne, Instagram, Twitter, Neural Network Newsletter Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Audio Engineering: Joel Hatstat at High Jump Media Chapters Featured playlist 25 videos Podcast Episodes with Guests Andrew Huberman 1,241 Comments rongmaw lin Add a comment... Andrew Huberman Pinned by Andrew Huberman Andrew Huberman 5 months ago (edited) I'm pleased to announce that I'll be hosting two live events in May 2022. These are part of a series called, "The Brain Body Contract: An Operating Manual for Human Performance." Tuesday, May 17th: Seattle, WA Wednesday, May 18th: Portland, OR Learn more at https://hubermanlab.com/tour Pre-sale tickets go on sale on Tuesday, March 8th at 10 AM PT (use code: huberman) 254 Juan Pablo Aranovich Juan Pablo Aranovich 5 months ago These two-part series on the Gut was amazing! Thanks Andrew! Sharing my notes. I posted this on Medium as well for your convenience (easier to read) You can find the links in my profile. What is the Gut Microbiome Is is the collective genomes of the microbes (composed of bacteria, bacteriophage, fungi, protozoa and viruses) that live inside and on the human body. The behavioral interactions can shift the gut microbiome, not just food. Microbes are all over our body, not just our gut. Gastrointestinal tract Most of microbiota are in the distal colon, but there are different kinds along the Gastrointestinal (GI) tract. There’s oral microbiota. Built to deal with oxygen. Grow in mats and are very structured. There’s microbiota in the esophagus and the stomach. These are not very dense. The stomach is a very acidic environment. There’s microbiota in the Small intestine. There’s microbiota in the Colon. This microbe community is density packed. Here, there’s ton of metabolic activity and bunch of interaction with the host. Microbiota: Where does it come from? We acquire our microbes thru a lot of different sources… The people we touch, the foods we eat, the pets we have, the environments in which we work… Depending on what microbes you get early in life you can send the inmune system in different developmental trajectories. Pets serve as a conduit for a bunch of microbes that we wouldn’t be exposed otherwise. A Healthy Microbiome What is a Healthy microbiome? It’s not clear, but a good rule of thumb is that a Healthy Micribiome is one that includes a lot of diversity. There’s tremendous individuality. Context matters a lot. A healthy microbiome in one place can be healthy in one place but not in another. Do we have a gut microbiome that is adapted to industrialized society? Or we all have an unhealthy microbiome because it hasn’t been able to adapt yet? The microbiota is plastic, it can change. But not too much. Microbiomes exist in stable states. It is hard to dislodge that community from that state. If we have a deteriorated microbiota, to solve it we need a combination of having access to the right microbes and nourishing those microbes with proper diet. Study in mice: They switched mice to a low fiber diet and high diet. Microbiota changed and lost diversity. But when brought back to a good high fiber diet, the diversity returned. Caveat: when the bad diet goes on for generations (four generations of mice in studies), the microbiome is very hard to recover. Fasting, Diet and Cleanses After a prolongued fast there is some auto-absortion of digestive tract. Mediterranean and plant based diets are the best. Plant-based fiber seems to be the most clever thing to do (whole grains, legumes, vegetables). For the health of the gut microbiota, short fasting (Time restricted feeding) seems to be OK. But there’s no clear evidence for prolonged fasting. It is not necesary to do a cleanse or fast prior to an attempt to repopulate the gut microbiome. We don’t need to flush out all our microbiota. Wiping out the microbial community seems like playing the lottery. There’s no data yet to support this. Processed food: Number 1 thing to avoid. Artifical sweeteners: really bad for the gut microbiome. They can lead to metabolic syndrome. Emulsifiers disrupt the mucous layer, which leads to inflammation. Probiotics and prebiotics can enhance microbiota diversity. But… Probiotics: Excesive intake can create mental fog. Prebiotics: Consuming a variety f plans is better in fostering diversity in microbiota than purified fibers (prebiotics). Dietary Differences Complex carbs can fuel the gut microbiota, which produces substances called short chain fatty acids (play essential functions). Complex carbs lead to low blood sugar. Human genetic adaptation to diet: over short periods of time, humans can adapt to differences in their diet. Best example: tolerance to lactose and dairy. The gut microbiome adapts to culture difference. Example: seaweed. People in Asia have genes that are able to digest seaweed, while people in the West usually don’t. But overall, we all come from hunter gatherers that ate mostly plants. Study of Hadza tribe (hunter-gatherers): They eat on average 100–150gr of dietary fiber per day. Only 1 of 30 hunts is succesful. So they rely in fruits and vegetables in the environment. They don’t PREFER plants. They do it because plants are available. Microbiome and the Inmune System The inmune system is really active in the small intestine to make sure that microbes aren’t getting so close. And if they do, there’s a response to get them back to theright location Metabolic and inflammatory diseases are all over the place during our age. The gut microbiome is critical to modulating our inmune status. If you change the microbiome you can fundamentally change how the inmune system operates. A poor microbiome sets a poor inmune system that gives rise to these diseases. Fiber & Fermented Foods They studied two groups. One was told to eat a high fiber diet and the other was told to eat as much fermented food as they could. Fermented food group results: Increase in microbiota diversity Higher diversity is generally better. Inflammatory markers decreased. Gradual ramping of fermented foods is important to adapt properly. Gut shot: you can take a little shot of the brine from the sauerkraut. Fiber group: They didn’t see the results that were expected. Some groups responded well but others responded poorly. When they analized it, they found out that if you have a diverse and healthy microbiome, you’ll respond better to a high fiber diet. This is because we need the right microbes to digest the fiber. Ripple effects of healthy diet. If you can affect your inflammation, you can affect your cognition and skin. There were not significant differences in cognition and mood in the study. Bowel habits improved with both groups. The sanitization of environment has gone too far. There are antibiotics everywhere. Exposure to microbes from environment educates our inmune system. Effects of microbiota in the body. The majority of inmunce cells are located in the gut. The microbes are only benefitial if they are located in the right spot. There are structures in the gut that take up microbes and “examine” them the microbiota manufactures chemicals that can go into the bloodstream. Twitter @Juampiaranovich you can find me and the article. 553 Peter Pourjafar Peter Pourjafar 5 months ago Hey Dr.Huberman. Can you please do an episode about the "unconscious mind' and the modern neuroscience's view on psychoanalysis. It would be interesting 606 Mark Bautista Mark Bautista 5 months ago Andrew I just want you to know you helped me overcome my anxiety disorder and in a couple weeks I’ll be running the LA marathon because of your endurance optimization podcasts. Can’t wait to see you in May, hopefully I can tell you thanks in person! 179 Andrew Huberman Weston Weston Weston Weston 5 months ago Thank you, Dr. Huberman for considering that people from all walks of life and income levels are consuming your content! 134 Andrew Huberman Warhag Warhag 5 months ago You are like one of those teachers, that shape you for the rest of your life. 117 Andrew Huberman Marques Smith Marques Smith 5 months ago This the greatest pod cast that I listen to. I'm extremely greatful for the information shared! 145 Andrew Huberman Devon Harris Devon Harris 5 months ago (edited) Another great ferment is Beet Kvass. Easy to make at home, just beets, salt, and filtered water. I always have either kraut or kvass 'growing' in my kitchen. My 7-year-old loves goat's milk kefir (super easy to make too) and I love this episode! 54 Madalin Sava Madalin Sava 5 months ago You can actually start making kombucha with no scoby (it's how I started): 1. Buy a bottle of refrigerated kombucha that hasn't been pasteurised. It should also say on the bottle that it contains live cultures. 2. Thoroughly clean your utensils, anything that touches the liquids. 3. Brew your tea, let it cool, add your preferred sugar. 4. Make sure the tea is at room temperature or slightly warm (hot will kill the bacteria), then mix with the bought kombucha. 5. Cover with cloth or something to keep bugs out but allows air to circulate, keep out of direct sun. A thin layer of scoby will start forming at the top, gradually thickening over time. Use a clean spoon to taste every few days after fermenting for a week, transfer the scoby to another batch and enjoy your kombucha. You can get more advanced with two-phase brewing for fizzyness and flavor but this should be a good starting point. 6 van phillips van phillips 5 months ago Ok, before I go, I gotta throw in a comment on his work with the Hazda. He is studying their diet in current day with current day food availability. Erks me cause I hear this one so often in studies. They can no longer hunt large animals not only because it's illegal now, but also cause they have been hunted to such low numbers. Their diet today has so very little to do with how they ate only ( guessing here ) 100 years ago or less. Then, it was the flesh and fat off of very large animals. The animals they can catch now, certain small ground animals, monkeys etc. have very little fat if any to for them to use as fuel, and thus MUST revert to carbohydrate foods like the fiber rich fruit he mentions, ( which also have been reported by others as a fruit where they spit most of the fiber out after chewing and 'juicing' with their mouths) and honey. Bottom line is it's too easy for researchers to cherry pick examples to substantiate their hypothesis. Real hunter gathers for thousands of years had abundant and now mostly extinct HUGE animals to hunt and gorge on meat and large amounts of fat. This data is substantiated and fact. One only needs to look for it. I"m disappointed he hasn't even touched on this fact of what ancestoraly we have eaten for the longest period of time while humans have existed. we usually believe in the diet we currently choose to be ideal. 8 Devon L Devon L 5 months ago When it comes to carb consumption. What makes the most sense to me is that if you genome originates near the equator, your body can tolerate carbs better because more fruit and vegetables grow in warm climates. Where as some groups of people, such as indigenous people of the great plains, do much better on a high fat, high protein diet because they originate further north where fruits don't grow in such abundance. 27 Michi Ackermans Michi Ackermans 5 months ago It's frustrating how little data is available on all meat diets. After 15+ years as a pescatarian I transitioned to a keto diet and shortly thereafter an all meat (beef) diet and my decades of debilitating IBS has vanished. Recent attempts to reintroduce plant fiber (because all beef is boring and gosh I love eating plants!) causes me immediate gut inflammation and discomfort. I'd really love to know the science behind all of this, there is an overwhelming amount of anecdotal evidence on the benefits of an all meat diet however no studies have emerged in an attempt to explain this. Unless I'm missing something, in which case please link said studies to this comment as I'd love to explore them! 14 Yazn Suleiman Yazn Suleiman 5 months ago I’ve been looking into gut health for a while now due to my insane IBS and random flare ups, God bless you for your knowledge and time ❤️ 85 Tyler M Tyler M 4 months ago Interesting discussion. It seems like all of the science behind all of these types of discussions simply comes down to something we have known from the beginning. Eat whole natural foods as they appear in nature - meat and plants. Eat like our ancient ancestors did. Lots of different ways to do this. Your body will begin reverting back to it's natural healthy state as your diet is returned to a natural state. The hard part is, they want us to continue eating junk so we can become dependent and they can control us. Thanks to everyone here for helping spread the word on eating a healthy natural diet and living a longer healthy life! 3 Dineslav Dineslav 5 months ago Playing the devils advocate here but, what if it’s not about the fiber, rather the bacteria found on the skin of plants as well as dirt/soil on them? Is there data that suggest we could generate scfa/ butyrate from collagen/ bone marrow, raw butter and other animal dense nutrients? I really enjoy the Huberman Lab Podcast. Thank you Professor Huberman for the effort and knowledge that you share! 21 Brady Wilson Brady Wilson 5 months ago (edited) So far I've watched 56 minutes of this. Speaking of plant consumption, Talking about how that should be the bulk of a diet. I think The Maasai tribe and the Inuits debunk that theory. Maybe this is addressed in the podcast and I just haven't got to that part. I think Andrew's theory of genetic background can influence diet to some extremes that maybe more beneficial to have a more carnivorous diet. I think I did hear that the Maasai do have honey from time to time, but I don't think there is fiber in honey. Diet is something I have really been interested in for a while and am always trying to be open minded toward different theories and studies. I've heard arguments from both ends of the spectrum. Vegans say meat will shorten your life and Carnivores say plants will shorten your life. Both with compelling arguments. But I believe carnivores arguments hold more water than a vegans. I have tried both diets. I felt much better on carnivore. Love your podcasts by the way Andrew. 16 chinawyte chinawyte 5 months ago Is coffee okay/good for the gut microbiome? I've thought of this for such a long time because I grew up visiting my grandparents' ranch frequently, since a baby - played with animals/dirt. By high school, due to fast food/inflammation, I had some mild acne and doctors would prescribe me various antibiotics or antibiotics for any little thing. By my 20's, I was frequently sick/constipated/bloated after eating. Early 30's, I went to an allergist and learned my body wasn't able to process foods I grew up on (one of the main ones was wheat/oats). Now that I know, things have been so much better. But when I first began to hear more about the gut microbiome, I began to think of how all the antibiotics likely affected me. Now, as an RN, I see how IV antibiotics affect my patients (most that need it, or they would die of sepsis). I'm hopeful of continued research on this - maybe transplanting microbiomes somehow once lost (similar to a fecal transplant)? But it seems so complicated and has its risk. Thanks for continuing to be my favorite podcast. Christine 3 J J 4 months ago I can say I followed the guest's recommended diet of a plant-based diet for 20 years. It wasn't keeping me healthy. I switched to keto, and in 3 months, I experienced an incredible transformation. Plant-based does not work for everyone. Some people thrive on animal-based diets. I also fast, drink raw milk kefir, and eat a little fermented veg each day. That healed me. Wish I had tried it decades ago instead of following the plant mantra. 15 Danijela Dani Ivanovic McGillicuddy Danijela Dani Ivanovic McGillicuddy 5 months ago Bravo Andrew for asking a right questions and intuitively sensing stuff too: So, what’s with this vegan/vegetarian agenda here ?!? Absolutely so many incorrect fact… too numerous to name it here, it’s just outrageous! Ex.: I don’t even believe in evolution as such, but like’ our ancestors eat berries when didn’t catch the meal?’ What?! Berries are seasonal- get your facts straight! Btw, vegan/vegetarian nearly killed me, and so many others, so I rest my case! I hate when people ‘hide behind the science’! Their lobby must be strong and it’s sadddd! Anyhow- I had to say this! Say the truth!!! 💪🤝👏 5 Casey McDade Casey McDade 5 months ago If this guy is the foremost expert on gut health then we need to divert millions from cancer research toward his lab so he can get the funding he needs to figure out what is really going on. I don't doubt his credibility, but get the man whatever he needs so he can provide more concrete answers. 5 Kimberly F Kimberly F 5 months ago It seems it's so ingrained to automatically say that cutting out meat-based protein and saturated fat is healthy. I'm not so sure that that is true, given that most data showing this are from epidemiological, and not controlled , studies. 11 Pinnacle Pottery Pinnacle Pottery 5 months ago I’ve been fermenting vegetables combinations like cauliflower/carrots/red peppers/onions for a year now. I do it in 64 oz Mason jars. I’ve tried a Turkish method of fermenting with adding raw chick peas to the brine. Works great! 20 Raj Ganesh Raj Ganesh 5 months ago Hey Dr.Huberman. Congrats to you for sharing vast knowledge about Gut health. Could you do the episode on Inflamatory arthiritis, rootcauses and to improve the situation 10 Tammy B Tammy B 5 months ago You lost me at Plant-based fiber filled diet. I also thought it was ironic that Dr. Sonnenburg states the Hadza eat a ton of fiber but only when their primary choice of meat and honey (which is seasonal) aren't available. 14 Maya's Dream Maya's Dream 5 months ago Amazing, as always!! Will you cover SIBO at all in this series? Thank you so much!! 10 LifeWithKyle LifeWithKyle 5 months ago Hey Andrew, love the podcast! I've been binge watching your podcasts ever since I came across your channel a few months ago, have learnt so much. Would you consider doing an episode on fatigue related illnesses such as Long Covid and CFS/ME? Would love to hear you do a podcast on this. 16 Skjöldur Kristjánsson Skjöldur Kristjánsson 5 months ago I would love to hear a discussion between you and Paul Saladino on the optimal diet. I had a hard time figuring out why Dr. Sonnenburg prefers a plant based diet, is it strickly better for longevity of life? As always a wonderful episode, thank you! 23 Rina Dror Rina Dror 5 months ago Thanks to Dr. Justin Sonnenburg who shared with us his research on gut microbiome and the importance of fermrnted food to health. Dr. Huberman's landing on directed questions from his field of scientific research also enriches the content of the discussion. Personal confession. In the last two years my family has completely changed the diet as recommended, and the improvement is noticeable in all areas. I sent the video to everyone. 9 Jay Lehman Jay Lehman 5 months ago Thanks for all of the great info as always! You did leave me wondering, though, why still the emphasis on fiber? The study you guys cite seems to indicate that higher fiber intake didn't show the kinds of results that were hoped for, yet Dr. Sonnenburg recited Michael Pollan's mantra and still seemed to insist on the benefits of a high fiber diet. Also, where can we go to remain informed about upcoming studies if we are interested in participating? Thanks again for everything! 21 Anita Boone Anita Boone 5 months ago As always, an amazing and valuable podcast. I so look forward to Mondays now 😉and listen to episodes more than once, they’re so packed with great info. Thank you for what you do! 2 SOMATICS with Laura V Ward SOMATICS with Laura V Ward 4 months ago Excellent! Thank you for this 2 part gut series. Andrew Huberman eilish neff eilish neff 4 months ago Absolutely fantastic discussion! Great questioning by Andrew lead to thoroughly informative answers by Justin. You both are doing really important work, and I’m so thankful that you are sharing your knowledge with the public. Much gratitude to both of you for this discussion and all the work that you and your colleagues share. 3 Luke Romo Hodges Luke Romo Hodges 5 months ago Do you think that Athletic Greens and similar products, rich in prebiotic fibers that are easily accessed, may cause flare ups and promote certain individual species of bacteria, rather than promoting diversity as Dr Sonnenburg mentioned when you asked him about prebiotic benefits in the last few minutes of this amazingly informative podcast? 3 360 Degrees 360 Degrees 4 months ago Please don’t stop your work, we absolutely love science, and can’t get enough of it. 10 Stefano Petri Stefano Petri 4 months ago Great podcast! A question on sauerkraut: since it's often consumed cooked, does the cooking process kill all the bacteria and so reduce its influence on gut microbiome? Thanks 4 James Hastings James Hastings 4 months ago I've been hyper focused on health for the past year and this is one of the best talks I've listened too!!!! Thank you Andrew! You're changing lives! 1 K Danielson K Danielson 5 months ago (edited) I LOVE your podcasts!!! Thank you so much for sharing such interesting, inspiring, important and practical Information so generously! Hope you will make it to the East Coast as well. 2 Lorraine Majcher Lorraine Majcher 4 months ago Hello Dr. Huberman, could you do a podcast on how to heal the body? I have chronic fatigue syndrome and would love to have tools on how to get your body in a healing state. Thank you for all you do!!!! 7 Garry Dzugan Garry Dzugan 5 months ago Thanks so much docs,another amazing podcast,and homemade ferments are easy and cheap to make like you said,I’m so grateful of all the knowledge you and your team has passed on to all of us,thankyou 1 Leni Olesch Leni Olesch 4 months ago Very informative mini series about the gut. In keeping with this content, I would like to know more about what happens to the microbiome after/during an Eating disorder. Since I am recently recovering from an ED, eating a lot of fibre and fermented foods, I experience a lot of gut issues and unpredictable upsets. 2 vinayak a vinayak a 5 months ago This podcast made me realise how absolutely clueless I was about my own body and mind :D. I have started implementing some changes based on the things I've learnt here. Maybe tomorrow will be a better day.... 5 Derrick Lytle Derrick Lytle 5 months ago On a personal level I feel best eating majority animal products with some fruit. I’m not anti plant but animal foods are generally higher in nutrients. To each their own I guess. 9 Emily Barry Emily Barry 5 months ago Been waiting for this episode since last Monday! THANK YOU for an absolutely FASCINATING conversation Andrew and Dr. Sonnenburg! The gut microbiome is my favorite topic and I love learning about all the new research being done in this area! I have heard that Natto is currently being studied for treating Alzheimer's, and I definitely believe that consuming fermented foods can positively impact brain health/cognition. Also, I can vouch for the "better poops, better moods" theory! I would love to see a Live Q&A with you both on Instagram soon. Thank you both again for your work,- FERMENTED FOODS FOR THE WIN!🙏💜🤗 3 Szilvia Lemke Szilvia Lemke 5 months ago (edited) Thank you for all your great work, I just LOVE this podcast! Topic suggestion: if you’d like to explore the magnetic field of the heart, how it carries informational patterns that reflect our emotional state. A useful part of this could be the magnetic radiation of our devices and how being around them all the time might influence our receptiveness of magnetic fields (and emotional states) of other humans and living creatures and if that has an effect on our perception of the modern world, how that affects our physiology, and if any connection to disease. Maybe you could interview Rollin McCraty from HeartMath Institute, or maybe you are aware of further suitable experts. Thank you for bringing us actionable information, science that is useful & fun! 3 PG PG 5 months ago In an article named "Sex Differences in Food Preferences of Hadza Hunter-Gatherers" (by Frank W. Marlowe) it is described that they spitt out most of the fiber, so technically they do not consume that amount of fiber. 9 darkeravocado darkeravocado 5 months ago (edited) Good stuff! Mark Solms would be a phenomenal guest, specifically in regards to where psychoanalysis is in relation to the neurosciences, including affective neuroscience. He’s very insightful into the nature of consciousness too. 1 Jivitesh Jivitesh 4 months ago Thank you Dr. Andrew for connecting science and tools. Please bring an episode on prefrontal cortex as it would be benificial for many people because it is the last part of the brain to completely develop and most affected by the environment and least affected by genes . 4 Gino Cedeno Gino Cedeno 4 months ago This was such a great episode!!! I can’t get enough of your content, every episode takes my knowledge and awareness to another level. Thank you so much for providing such valuable information. 🙏🏽 4 Jessica Baskin Jessica Baskin 4 months ago This was so fascinating and helpful. Thank you Dr. Huberman & Dr. Sonnenburg! I'll be checking out The Good Gut next. Two questions for you: Have there been any studies on childhood cancer and the gut microbiome? And any data on spore probiotics (don't need to be refrigerated and can be consumed at nearly any temperature) vs. other types of probiotics? Thanks so much! Catherine Bell Catherine Bell 5 months ago When this podcast #62 popped up, and I saw that it was over 2 hours long, I grabbed my whole food prep ingredients and adjusted volume to never miss an insight from this very informative, educational session! Thank you for more pearls of wisdom😊👏🏻. 3 Nasira Spells Nasira Spells 5 months ago I just finished listening to this episode on Spotify and it was so great to hear. Informative and confirming of things I knew👏🏽. Thank you for your work. 1 Mario Suárez Mario Suárez 5 months ago (edited) excellent! this is probably the best guest you've had in the podcast, and that's a tough decision to make. incredibly thorough, interesting, humble, passionate and clear. looking forward to the findings on the mix of fermented and high fiber foods. I am not likely to have those servings described in the separate studies. I also get that the high fiber diet does its job too, in addition to keeping one away from carbohydrates. Kevin Harrison Kevin Harrison 5 months ago Thank you for exploring the science of this wonderful subject. In addition to Dr Hubermans recommendation on fermented foods, the book The Art of Fermentation by Sandor Katz is a must have if you want to follow making your own foods. I asked for it 2 years ago and have never looked back. Fermenting your own foods is not complicated or as scary as people imagine and so very inexpensive to make. My family thought I was weird at first but of course now after some education they are eating with every meal. I just treat it like a vegetable which it is! 1 Be Your Unique Potential ~ Sleep Meditation&Music Be Your Unique Potential ~ Sleep Meditation&Music 5 months ago This is very timely. Thank you. It is good to find what works for us. I love kefir morning and evening for gut health. This along with the ayurverdic herbs ashwaghanda and shatavari really help calm my brain before sleep too. 1 Francesca Bevilacqua Francesca Bevilacqua 4 months ago thanks so much to both of you for another information packed pod cast..A lot to digest🙂 2 William Chitangala William Chitangala 5 months ago (edited) Very insightful episode, thank you. 🙏🏾 Is it possible to further elaborate on recent articles, research and knowledge about the lung microbiome? 4 Isabelle Ebel Isabelle Ebel 4 months ago HI Andrew, since you started this podcast I didn ´t miss a single recording! Mondays really have become my favorite days since then! is there any chance that you will be hosting events in Europe in the near future? Would be awesome! Sean Moore Sean Moore 4 months ago Best Podcast on health that I've found. Andrew, you are a great man doing this for us all. 2 Shubha Amba Shubha Amba 5 months ago Thanks for this fabulous podcast. Curious about how disadvantaged we are or not consuming regular vs organic plant-based diet. Sideth Kang Sideth Kang 5 months ago Very informative and useful discussion. Million thanks Dr Andrew. 1 Jo-Ann Sloan Jo-Ann Sloan 5 months ago My favorite podcast! Who would’ve guessed I would choose to listen to science instead of shop online 😍 5 Roger Zen Roger Zen 5 months ago Great episode! Would also love to hear about the interplay between the gut microbiome, the brain, and mitochondria. 39 Jane Kirkwood Jane Kirkwood 5 months ago Super fascinating topic, thank you both for this episode. I have to say, that in my own experience, I've had colonoscopies carried out for medical reasons and in preparation for them I had to be flushed out using powerful laxatives. Every time, I experienced feeling quite unwell and I believe it was due to the impact on my intestinal microbiome, so I don't think flushing is at all good for us. 20 amgod40 amgod40 5 months ago My wife’s company just sent us literature on getting our digestive heath checked free of charge as a part of our insurance plan. I was pumped that this is being adopted and being made more mainstream 18 Katalin Halom Katalin Halom 5 months ago It's a pleasure to listen to Dr. Sonnenburg. Also, Prof. Huberman poses poignant questions and he does listen to the answer!! 5 Nina Nina 5 months ago Thank you so much for this series!!! I deal whith this kind of problems for a while and I am glad medicine takes a step in this direction. (Helping people to restore gut microbiome balance). Such a big impact in our health and yet classic medicine has no real interest in it. Because it is not about medicines they can sell. It is about diet mostly! What kind of specialist we should see for those issues? From previous experience first thing a Gastroenterologist recommends is Colonoscopy, which alters the microbiome further. I would love to hear your opinion about Saccharomyces boulardii fungal probiotic. It was recommended to me, helped on short term, but I think on the long term made things worse. I will try for sure the fermented foods diet, taking things slowly. Thank you and best regards! 1 Anita Peters Anita Peters 5 months ago Thank you so much for this very informative podcast, I try to listen to most episodes. These were of particular personal interest. housejunky777 housejunky777 5 months ago (edited) Have been looking forward to this podcast. Thank you Doctors Huberman and Sonnenburg! 10 Stef Stef 5 months ago absolute 100% quality podcast once again! Jeffrey Harrison Jeffrey Harrison 4 months ago Fantastic show. I love the Sonnenburgs and their research 2 Donna williams Donna williams 3 months ago I'd like to thank YOU and your guests for providing the information you so generously share with all of us. My question is if there has been or is in progress a study regarding whether or not there is additional benefit from consuming fermented vegetables grown in your own garden as opposed to those purchased from a grocery store. Li Pan Li Pan 3 months ago Thank you Professor Huberman! Excellent episodes! I would like to know more about how common chemical can damage our gut and health. In future episodes, can you talk about how our health is affected by things like pesticide, herbicide, detergent, lectin, mouthwash, and etc. 6 Porporrina Porporrina 5 months ago I have listened to your Podcasts, more than 2 times on each episode. I really enjoy them!! How big is one serving for those fermented food?? Thank you 😊 5 Nigel Clack Nigel Clack 5 months ago Thanks for doing what you do! A lot if not all references appear to be compared to the Hazda who live near the equator. What plants and carbs grow in the UK and N US in winter? I'm not disputing the benefits of plants for our guts but for many parts of the world, surely it has to be seasonal? Thanks. 4 C. Proscurchim C. Proscurchim 4 months ago My midwife at the time was doing research on mom and baby microbiome with NYU and i was part of it , she's such a great researcher . 1 Henri Kuusisto Henri Kuusisto 4 months ago Thanks Andrew! Awesome stuff again! I was wondering if gut microbiome has something to do with circadian rhythm regulation? I happen to have very irregular circadian rhythm since birth. My parents used to joke about that saying I was born in wrong continent/time zone. Partly my ADHD explains that, but I've had better periods of time while maintaining normal circadian rhythm has been relatively easy. I've tried to maintain pretty balanced diet including kimchi and other fermented non sugary goodies for many years now. I've been backtracking main incidents including any illnesses, prescripted antibiotics, stressors an so on. I've also managed to get some understanding that during antibiotics, I usually feel guite good even if I'm sick from some infection or so. After a round of antibiotics I'll usually get some swelling and itching with brainfog when all the antibiotics has been eliminated from my system. Weeks or months after I'm starting to feel fatigued. I've found some probiotics which helps with the brainfog and fatigue. But the most interesting thing was that maintaining regular circadian rhythm was really easy, almost natural during the rounds of that particular blend. I know that I'm cutting all the corners here jumping in conclusions that probiotics helped to maintain my circadian rhythm. But I'm really interested could it be so and whats the mechanics in the background if so. And at the moment I'm yet again struggling with my sleep patterns. These episodes of gut microbiome shed some light into that also since I've had almost two years of extreme stress following severe burnout. Also yet again one round of antibiotics during that time and now my circadian rhythm has gone totally haywire. It's like my body does not react to protocols that used to work (bright light, training and food at right time etc.) So once again as my own human guinea pig I'm about to start a round of that particular probiotics blend and see what will happen. Would be really cool if you could do another episode about gut microbiome in the future from perspective of circadian rhythm. Anyway, a thousand thanks and greetings from Finland!! Rebecca Manning Rebecca Manning 4 months ago Having recently had a massive bacterial infection that required a week of strong intravenous antibiotics, the podcast was perfect timing but has raised a couple of questions for me. 1. If I take a high quality probiotic, do the bacteria in it make it through the acidic conditions of the stomach and then small intestine, or are a large portion of them lost? 2. How long can I expect it to take to repopulate my gut, if I started with a reasonable healthy microbiome because I already follow many of the protocols given by Dr Sonnenburg? Thank you for continuing to bring us such great content, always learning. C Low C Low 5 months ago Please complete these Gut Microbiome episodes with an interview with Sandor Katz. Not only has he built a fermenting community (pun intended) worldwide, his knowledge of fermentation and its culture worldwide (pun intended) is second to none. His personal health journey is truly incredible. 2 Hiroaki Hiroaki 5 months ago Hello Dr. Huberman, thanks for another great episode I have a question about neuroplasticity (just listeed to your new Rich Roll interview): How good are people at naturally “feeling” the 15% optimal rate of failure during practice and the 10:1 ratio of random breaks doing nothing? From my experience playing the guitar, I know that I naturally do both look for a certain rate of mistakes and that sometimes (mostly when I feel like I’m starting to make more mistakes) I will naturally take a break or at least shift to a different exercise. I think most athletes and musicians do the same, but I wonder how accurate this intuiting is? Nicole Marie B. Nicole Marie B. 5 months ago My friend had his colon removed due to chrons. What does mean for his microbiome since his biggest reservoir is gone? 6 Karl Miller Karl Miller 5 months ago Thank you for this discussion @Andrew Huberman. Thank you for attempting to bubble up some of take-aways for us mere mortals. Your work and perspective is important. In this episode, we discuss: Dr. Davis’ fascination with gut health Defining SIBO, SIFO and dysbiosis How microbes & LPS can enter the bloodstream Signs & symptoms of SIBO 2 herbal antibiotic recommendations to treat SIBO Treating SIBO with good bacteria Dr. Davis’ L. reuteri fermented yogurt Paying attention to probiotic species & strains Lactobacillus reuteri releases the hormone oxytocin The disappearance of L. reuteri over the years What are keystone species? + Ways to restore them The secret to making fermented yogurt at home Ideally, mom will expose baby to Bifidobacterium infantis The probiotic of the future Fermented foods vs. prebiotic fibers Dr. Davis’ “love dream” The overuse of antibiotics The tragedy of statin drugs How to minimize the damage of antibiotics Dr. Davis’ fermented cider recipe Machine recommendations for making fermented yogurt Prebiotic fiber recommendations SIBO & prebiotic fiber How much prebiotic fiber should you consume? Raw white potato is a great source of prebiotic fiber Tips to avoid the recurrence of SIBO Treating SIFO (fungus) with supplements Die-off reactions + supplements to help tame them Show sponsors: Organifi <== 20% off all Organifi products by using the code ultimatehealth at checkout Paleovalley <== 15% off all Paleovalley products by using the code ultimatehealth at checkout BiOptimizers <== 10% off BiOptimizers’ Biome Breakthrough by using the code ultimatehealth at checkout Related links: Dr. William Davis – Super Gut (book) Dr. William Davis’ website Follow Dr. William Davis on Facebook, Instagram, and Twitter Dr. William Davis – Undoctored (book) Dr. William Davis – Wheat Belly (book) Listen to Dr. William Davis previously on TUHP (episode #153) AIRE device BioSource Evivo Baby Probiotic – Bifidobacterium Infantis EVC001 BioQuest – Sugar Shift Florastor Related episodes: This Is How to Live Longer & Prevent Disease by Fixing Your Gut Health | Tina Anderson (#451) 367: James Hamblin – The Impact Of Not Showering For 5 Years 289: Dr. David Perlmutter – Brain Maker • Reconnecting With Nature • Exercise Impacts The Microbiome 124: Dr. Jill Carnahan – Toxic Mold • The Gut-Mind Connection • SIBO 101 078: Dr. Robynne Chutkan – Microbiome 101 | Stop Sanitizing Yourself Sick | Having A Dog Will Boost Your Health Dr. William Davis photo credit: Kelly Steinberg How can you support our podcast? 1. Apple users, please subscribe and review our show on Apple Podcasts, we make sure to read them all. Android users, be sure to subscribe to our show on Google Podcasts. Subscribers never miss any of the action 😉 2. If you’d prefer to watch vs listen to the interviews, head over to our YouTube channel and enjoy the full video conversations. Be sure and subscribe while you’re there. 3. Tell a friend about The Ultimate Health Podcast. They will surely thank you later. You can use the envelope button below to email a friend or tell them about TUHP in person. 4. Join TUHP Facebook community (FREE). This is where we all stay in touch and ask questions in between episodes. Join our community. 5. Follow our adventures on our favourite social media platform, Instagram. 6. Download The Ultimate Health Podcast app (FREE). This way you’ll have our whole library of episodes right at your fingertips. Download our iOS/Apple app or our Android app. 7. Share using the buttons below.