The Role of Mitochondria in Aging and Disease - David Sinclair 249,659 viewsMar 6, 2014

The Role of Mitochondria in Aging and Disease - David Sinclair 249,659 viewsMar 6, 2014 Serious Science 91.6K subscribers Source - http://serious-science.org/videos/738 Harvard Prof. David Sinclair on alphaproteobacteria, reactive oxygen species, and why the nucleus and the mitochondrial genomes are like a married couple 515 Comments rongmaw lin Add a comment... hamed shahbazi hamed shahbazi 6 years ago Amazing work Dr. Sinclair! So impressed with not only your work but your ability to explain it!! 28 Debasish Borthakur Debasish Borthakur 2 months ago OMG.. He is just genious.. Everyone please support Dr. David Sinclair.. He is doing a fantastic job.. God bless you.. 4 Carroll Hoagland Carroll Hoagland 5 years ago (edited) Thanks Dr. Sinclair .. a fan ... will be watching the outcome of your research ... since I am specializing in mitochondrial dysfunction pertaining to aging from a dietary approach, since as you know we have longevity mechanisms that repair all damage ... we just have to get out of there way and support our own metabolic processes as these bodily mechanisms are far more powerful than any supplement you can take ..., 70 Going On 100 … the Centenarian Diet … maybe 70 Going On 128 … the Hayflick Limit, or if a fan of Ray Kurzweil … then this is all a Moot Point. 22 Biophilia Biophilia 1 year ago (edited) Sir I have read Your book "Lifespan" on the same topic of aging - It was too informative ..I am Your big fan 😇..Loads of love from India. 9 William Tomkiel William Tomkiel 2 years ago so glad I found this . . Been on NAD, 100 mg. /day for almost 2 1/2 years along with Co-Q10, Carnitine and Creatine as also being mitochondrial supporters and at 72 function and perform as a man many years younger but it's also about sleep , stress, recovery protocols for the gym work-outs and so forth. 19 Rock Forester Rock Forester 3 months ago So exciting! One can try a lot of this right now, and very safely. My goal is to live heathfully for however long I do live, and this research is exactly the ticket. ido shapira ido shapira 3 years ago Great lecture, sounds like the progression of insulin resistance. Thank you 10 Alex Alex 2 years ago (edited) Wouldn't it be possible to look at the mitochondrial bacteria types which are living outside of human bodies, where they are less protected, to find some gens which could be used to make our Mitochondria more resilient to damage and mutations? 4 Benjamin Hardisty Benjamin Hardisty 7 years ago I'm actually an aging researcher myself. Trust me, the Sinclair lab is top notch. SENS is funding great work, but they're not bringing anything to market in the next 10-20 years is my guess. I don't even think the NAD treatments or protein chaperone treatments Sinclair's lab is studying will get anywhere for years either. Consider that mTOR suppressors can both raise and lower lifespan and we don't fully understand why and we've been using them for decades to get an idea of the technical challenges. My mTOR model is a 26 ODE system. My lab mates said, "Oh that's why no one's made a good mTOR dynamics model." 22 Hobby Farmer Hobby Farmer 6 months ago Dr. Sinclair looks younger now (2022) than he did in 2014. That means his approach worked, i.e. diet, intermittent fasting, supplements, etc. 11 Debasish Borthakur Debasish Borthakur 1 month ago The world is watching you Dr. David Sinclair.. You are our hope.. saxmanchiro saxmanchiro 7 years ago It's a hypothesis, not a theory, yet. This reminds me of Dr. Dean Ornish's idea, back in the mid 80s, of reversing heart disease with diet only, quickly. Many in the medical field scoffed at him and chastised him for his foolishness. Now we know the truth. He was right. Sometimes, a crazy idea in science gets ridiculed until the irrefutable evidence comes in. Could be a game changer for sure. 54 Halima Zamouche Halima Zamouche 2 years ago All your work is amazing! Wish you all the best! You only need to get this you can live healthier and maximise your body's performances but you will certainly die! Thats sad but it's a fact that we can't deny! Everybody dies and it's for a reson if people that lived before us didn't die we would be looking for another planet to live in! Even cells in our bodies die when other new ones appear! God bless you! 1 Raven’s Lair Raven’s Lair 4 years ago Excellent. A very well spoken Professor. I have so many questions! Would taking NADH assist in this regeneration?? 5 Baljit Singh Baljit Singh 1 year ago Very informative information 👍🙏 2 Joseph Ruhinda Joseph Ruhinda 11 days ago Bless God for your beautiful mind and your contribution to human evolution and civilization. Love from Uganda 🇺🇬. Much appreciated 🙏🏿👍🏿 Carlos Lopez Carlos Lopez 3 weeks ago Wow loved this video!! Thank you David! Elena Benjamin Elena Benjamin 1 month ago Thank Dr Sinclair. Can you please talk about fisetin! ? How we can take? I understand that it help the mitochondrial function! 🙏🏼🍀 2 Command Results Command Results 7 years ago Great talk theorizing the future of mitochondrial development as related to aging and longevity, 3 Vicente Sanchez Vicente Sanchez 2 years ago Excellent lesson and info. Thx 1 Serious Science Pritam Borah Pritam Borah 7 years ago your analogy of the broken marriage of genomes was the best part.... 65 ZeraYaqob ZeraYaqob 2 years ago The human microbiome directs the communication between the cells and mitochondria as well as between other cells. One example is the role of menaquinone or vitamin K2, synthesized from vitamin K1 or phytonadione by certain bacteria in our gut, as a participant of the oxidative phosphorylation or electron transport chain (where 94% of cellular energy is produced) through its ability to accept and transfer electrons. 16 tigerkills tigerkills 2 years ago Every medical professionals should learn this. Kevin Fairweather Kevin Fairweather 4 years ago Very succinct explanation ! 1 JAMES B. JAMES B. 8 years ago The first NAD+ supplement was just introduced by the same company that developed both the first high potency Resveratrol and Pterostilbene supplements, Biotivia LLC. It is by no means cheap but if it were it would probably not be genuine. The name of the supplement, which is extremely limited at this point in time, is Mitotrans. 2 Nicoleen Wentzel Nicoleen Wentzel 2 years ago I am 59 years old. My husband is 64. I feel like I am getting younger. I have lots of energy and are able to do 12 hours hard labor. My husband looks like a really really old man. I often wondered if I am too young for him or if he is too old for me. My whole life I had the idea that I am slow. It is strange and I could never really understand why I am years behind other people. I do catch up eventually but then they are old and I feel young. Today something just popped up in my brain: Micro Con dial. I had no idea what it is, so I googled and find this video by David Sinclair. Does this make any sens? 3 Winston Chang Winston Chang 3 years ago Very insightful, Doctor Sinclair. I can clearly see the worth of you living a longer life because you are an important part of human society with your intelligence and knowledge. You are our mitochondria. But , what do I do with a longer life or that of billions of people. ? .....?....Like , I do not want mice to live longer lives..... 6 Graeme Gladman Graeme Gladman 5 months ago You need to research vit K2 or and L - Citruline for its anti aging effects. It has wiped my wrinkles and made me years younger. I don't know which one is responsible or it could be a combination of the both. Glenn Decker Glenn Decker 6 years ago Great ideas, but more basic science questions should be asked at the level of cell biology and ultrastructure. 4 Tomas Hull Tomas Hull 2 years ago Aging can't be stopped... Everybody dies... Some signs of aging could be slowed down and reversed... temporarily... The cell division processes breaks down eventually... the telomeres get shorter each time it happens... mutation load in increases with age... It's all driven by quantum mechanics... 3 IW Nunn IW Nunn 3 years ago I don't want to live forever. I just want to be healthy and live an optimum life while I'm in this body. 63 Mark Chan Mark Chan 6 years ago Thanks it is fascinating! 7 Ivan O Driscoll Ivan O Driscoll 3 weeks ago Cool video and understandable. Chris McAulay Chris McAulay 7 years ago Incredible - now I just need to find a reason to live - lol 276 kittyhooch1 kittyhooch1 2 years ago After this watch a recent video of him. Six years later he is visibly younger. 17 Srtj.Av. Srtj.Av. 5 months ago I love when he smiles as is a good thing happening! 😊 #mitochondria #cells #humanbody Mitochondria Aren't Just the Powerhouse of the Cell 254,212 viewsApr 16, 2020 10K DISLIKE SHARE DOWNLOAD CLIP SAVE Seeker 5.08M subscribers Mitochondria are so much more than the powerhouse of the cell. In this episode, Patrick explores why this organelle is so unique and introduces new research that you probably didn’t hear about in school. » Subscribe to Seeker! http://bit.ly/subscribeseeker » Watch more Human! http://bit.ly/HUMANplaylist » Visit our shop at http://shop.seeker.com “The mitochondria is the powerhouse of the cell,” has got to be the most repeated line in biology. It has been firmly inserted into our middle school textbooks for years, and the powerhouse nickname stems from the mitochondria’s energy production capabilities, but the mitochondria offers so much more than that. To start, when discussing all the mitochondria in our bodies, we use mitochondrion for singular, mitochondria for plural. Each Mitochondrion looks different from cell to cell, and there are hundreds of thousands of mitochondria floating around in your cells—though that number also depends on what tissue we are referring to. But, regardless of shape and number, all mitochondria do have some structural things in common: They each have two membranes—one outer layer, one inner layer, and some space in between them. While the outer membrane works like a protective but permeable layer, letting different compounds in or out of the mitochondrion, the inner membrane is where some important biology happens to manufacture ATP (or Adenosine triphosphate, an organic compound that provides energy to drive processes in living cells). So how did we develop mitochondria and what are all the things they do for our bodies? Find out more about endosymbiosis theory and all the different roles your mitochondria play in this Human. #mitochondria #cells #humanbody #health #biology #seeker #science #human Read More: Why do our cell's power plants have their own DNA? https://www.sciencemag.org/news/2016/... “It’s one of the big mysteries of cell biology. Why do mitochondria—the oval-shaped structures that power our cells—have their own DNA, and why have they kept it when the cell itself has plenty of its own genetic material? A new study may have found an answer.” Cells Living in Cells https://askabiologist.asu.edu/explore... “It’s good to be friendly with your neighbors, right? Individuals and communities do better if they help each other out. Cooperation isn’t just important for humans; without a bit of interaction with neighbors, life as we know it would not exist.” mtDNA and Mitochondrial Diseases https://www.nature.com/scitable/topic... “Did you know that you have a second genome? Small cellular organelles called mitochondria contain their own circular DNA. What happens to your cells when this DNA mutates?” __________________ This Seeker health miniseries will dive deep into the cellular structures, human systems, and overall anatomy that work together to keep our bodies going. Using the visual structure and quick pacing of Seeker’s Sick series, these human bio-focused episodes will give a new audience an inside look on what’s happening inside all of us. Visit the Seeker website https://www.seeker.com Seeker on Facebook https://www.facebook.com/SeekerMedia/ Focal Point on Facebook https://www.facebook.com/FocalPointShow/ Seeker on Twitter http://twitter.com/seeker 808 Comments rongmaw lin Add a comment... Sciencerely Sciencerely 2 years ago I'm a biomedical researcher just working with a mitochondrial protein called IDH. IDH is involved is normally involved in the citric acid cycle (the pathway which eventually drives the production of ATP in mitochondria) but specific mutations inIDH are also frequently found in different cancer types. The reason is that mutated IDH can lead to the production of a harmful molecule which messes up a lot of proteins leading to the repression of genes which would normally protect against the development of cancer (I would love to make a video about that mechanism one day). After so many years of research, mitochondria still show fascinating new sites! 526 Just Some Guy without a Mustache Just Some Guy without a Mustache 2 years ago So the heart muscle cell has an average of 35 to 40% mitochondria per volume? That's amazing. It makes sense since it's still very active even when we sleep. 126 Josi Ha Josi Ha 2 years ago The mitochondria is the powerhouse of the cell! 1.1K Vicarious Gamer Vicarious Gamer 2 years ago Cool ! My college days ended in the late 90's. My favorite classes were A&P lecture and mostly lab. The cell structure, constituents, and function was my favorite point of study, primarily the Mitochondria. I was fascinated by this micro powerhouse. It seemed so surreal. I was wondering what new developments would arise in the future after further research was performed on this particular particle of wonder. So, once again... Cool ! I look forward to learning more about this subject matter. 12 BizAutomation Automating Small Business BizAutomation Automating Small Business 2 years ago Would love more about how Sirtuins and NAD play a role in the mechanism. As you know NAD boosters NR and NMN are a big part of the anti-aging right now (will look forward to the ATP video). 8 Andy Bryson Andy Bryson 2 years ago These Human versions of Seeker are truly awesome. I really enjoy them. Teaches me SOOoo much!!! Way to go. But dont stop the other regular Seeker videos. Luv watching all of them 4 noman afzal noman afzal 2 years ago Patrick is doing a great job on seeker, i like very much his medical related videos 38 Anon Amuss Anon Amuss 2 years ago As a person with mitochondrial diseasr I'd like to say thank you for creating this video. It is one of the best I've seen on the topic. 26 Business Madhouse Business Madhouse 2 years ago I have been following you since the very beginning and have seen you grow. Your work and dedication has inspired me to start my own channel and put in a lot of effort Looking forward to your support and advice as always! 5 haipabli haipabli 2 years ago The real question is: What is the powerhouse of the mitrocondrion??🤔 273 HitomiOokami HitomiOokami 2 years ago i really adore this series. you're doing a great job Patrick 1 A Recurring Problem A Recurring Problem 2 years ago Not often that a video goes "but you may ask..." with what I was actually asking. So glad I don't have to sacrifice any sleep time to solve unanswered questions! Loving this series. 2 ShaVaughn Peterson ShaVaughn Peterson 1 year ago I'd always thought each cell had one mitochondrion 😳 4 Lone Star Lone Star 1 year ago Thanks doc for this interesting and simplified video yet informative indeed 2 Andrew Maddux Andrew Maddux 2 years ago Mitochondria's relationship to cancer is far stronger than you indicate. Please expand with a video on the Warburg Effect - a very recent area of research focus and something most people with cancer can take advantage of themselves to greatly increase the effectiveness of standard therapy. 1 Jake Mcfee Jake Mcfee 2 years ago my god, the hosts of this channel are just perfection in the way they narrate everything, How do they do it? 2 Corporis Corporis 2 years ago This was a fun episode to write, hope you guys like it ☺️ Aaron Stafford Aaron Stafford 2 years ago Can you provide a link of fossil records or confirmation of a mitochondria that is not within a cell? 3 Aledy Haliedaff Aledy Haliedaff 1 year ago Seeker teaches me more than in school. My school only taught me that Mitochondria is powerhouse of school. This is blown up my mind 😳 1 Hyrulia Hyrulia 2 years ago The cell is the power mitochondria of the house! 489 Stefan Babel Stefan Babel 8 months ago Would it be possible to modify the mitochondira to accept electrons from a metal wire instead of using NADH ? This way all cell could be powered without nutrients but with pure electricity. Is there any research on that ? :) Just curious. eukaryotic 070 eukaryotic 070 2 years ago If you want to learn theories on how mitochondira evolved, Nick Lane wrote a book called "Vital question" goes in depth about endosymbiosis and Chemiosmotic coupling. 14 Salomon Arreguin Salomon Arreguin 2 years ago Millions of years ago, a mitochondrion walked into a bacteria and BAM! Science. 6 your comment might not work so please your comment might not work so please 2 years ago Apart from the meme,i did learn something NEW MITOCHONDRIA is also the POWERHOUSE of our ANCESTORS. 34 Brenden Carr Brenden Carr 2 years ago Soon enough, our minds will be equipped with the tools in order to fully understand and manipulate these processes, perhaps guide them, create them from scratch, or even get creative with all of it. I'm definitely excited to see what heavy artificial super intelligence will help us with too. A time in our future where technology makes an exponential leap forward will be soon if we find out techniques to tune our minds with this nano scale protein based technology. Mohd saleem malik Mohd saleem malik 1 year ago Amazing teaching, very helpful Melchizedek Phuah Siow Jin Melchizedek Phuah Siow Jin 2 years ago I was introduced to mitochondria when I first played Parasite Eve. Fascinating. Thanks for the video! 3 crazyrobloxjaden crazyrobloxjaden 6 months ago Mitochondria are known as the powerhouse of the cell because it is responsible for the extracting energy from food through cellular respiration. The energy is released in the form of adenosine triphosphate (ATP). It is an energy currency of the cell. but not always J P J P 2 years ago I definitely understand it more than my previous bio classes haha persona persona 2 years ago (edited) Me : Sees Video Title Also me: years of academy training wasted 531 Krishnanshu Yog Krishnanshu Yog 2 years ago Funfact: the mitochondria of eukaryotes have its own 70s ribosome the same ribosome found in prokaryotic cell. Whereas 80s ribosome is found in the eukaryotic cell 1 Unconventional Wisdom Unconventional Wisdom 1 year ago I wonder if "The mitochondria is the powerhouse of the cell" will become an eternal meme that is passed down in our culture for as long as children are taught biology. 2 Last Chance Last Chance 2 years ago Have DNA databases identified the likely bacterium responsible for endosymbiosis? Enayat Nazhat Enayat Nazhat 2 years ago awesome informative stem video > keep them coming! Chester W Chester W 7 months ago DO you have a direct channel? I like the way you explain your theories Julio Quinones Julio Quinones 2 years ago Look up parental mitochondrial DNA inheritance. I remember seeing developments that might put in question the maternal inheritance theory. 2 Prevenge IX Prevenge IX 4 days ago 2 1/2 years later....still the powerhouse of the cell! Tam McD Tam McD 2 years ago 8:56 "making the mitochondria a warning signal that something bad is happening" .... which fits with the CENTRAL role of mitochondria in apoptosis (programmed cell death). 10 Cam plays Cam plays 2 years ago Heart: laughs in mitochondrial superiority 75 random random 2 years ago This guy can be the powerhouse to my cell all night long =P 1 Dick Tejano Dick Tejano 2 years ago I learn so much from these videos. I wish they would have taught like this is my High School. 4 GuidetteExpert GuidetteExpert 1 year ago Mitochondria was a seperate organism before it joined a animal human sell! Because it has its own membrain and inner membrain and even a genetic copy inside. Neuro Philosophers Neuro Philosophers 1 year ago (edited) A year before this post they’ve shown we inherit mitochondrial genes from both of our parents and a study in 2002. But only when a mutation prevents the normal removal of the speed mitochondrial dna. 1/5000 apparently have mitochondrial dna from past male relatives Susse Kind Susse Kind 2 years ago Don't stress yourself out about it, nobody could be as boring as my high school biology teacher. He made Ben Stein look animated. Shen Shen 7 months ago Such a great knowledge I learnt. It's help alot for me as a beauty consultant. Silverfirefly1 Silverfirefly1 2 years ago (edited) Mitochondria to each other: Remember guys, the cell is the powerhouse of the world domination. 23 My. Thought My. Thought 1 year ago (edited) It is interesting that he kept saying the 'purpose' of the biological response. As an engineer I assign a purpose by designing the right sequence of events to achieve the outcome I desire. Sidney Ibiom Sidney Ibiom 9 months ago Thank you so much You've answered all my questions GameCone Productions GameCone Productions 2 years ago (edited) How do a symbiotic pair reproduce? Does one side reproduce and then the other, do they do it simultaneously? Do they ever leave their partner behind? What gives, how do they coordinate? thedeathcake thedeathcake 5 months ago Nice video. Great presenter! Ben Robson Ben Robson 2 years ago Everyone: The mitochondria is the powerhouse of the cell Me: come on guys, really? Also Me: The mitochondria is the powerhouse of the cell 128 Mariano Alippi Mariano Alippi 2 years ago I thinks that it is good to explain what Autdesk is doing to cure future pandemics, but the security of that technology is even more important than the creative part, explain in Seeker how this security is going to be implemented. rodylermglez rodylermglez 2 years ago I sometimes forget that we all have symbionts inside of us... Like Venom >:3 3 Baze Baze 1 year ago Great, PERFECT, everything I knew from school gone now thank you Stone624 Stone624 2 years ago "Has been firmly inserted into our Middle school textbooks for years" High School Biology : Am I a Joke to you? 4 Farel Rajwa Farel Rajwa 2 years ago The most scientific popular meme Also Mitochondria is the powerhouse of the cell! 1 micromelis micromelis 2 years ago If you get an organ transplant, what’s happens to the mitochondria in the transplanted organ? Aliya Aliya 2 years ago Hi. Can you make a video about chloroplast too? Thank you. Juan Lagarde Juan Lagarde 2 years ago Mitochondria are awesome organelles! 1 Boris Petrov Boris Petrov 2 years ago Outstanding — thank you !! 1 Insanitys Reign Insanitys Reign 2 years ago Hmm, that's interesting! Can't wait to learn more! 1 Black Adder Black Adder 2 years ago The more mitochondria you have, the stronger you are in the Force. speedy01247 speedy01247 2 years ago (edited) mitochondria are the pets to our cells. (imagine if one day if the mitochondria decided to rebel and kill us all) 4 Jedi MGTOW en el Exilio Jedi MGTOW en el Exilio 2 years ago (edited) You can also say that the Mitochondria is like a midichlorian to a cell. 1 Gert van Cappellen Gert van Cappellen 2 years ago Mitochondria are tube like structures and not the beans that everybody is showing. For a moment I thought you were really going to show how mitochondria look like, it are dynamic tube like structures that you can easily recognise with a fluorescent microscope. What is shown here and in many textbooks are the EM intersections of the mitochondrial tubes. Off course this is known for quite some time, but very hard to change the way people look at mitochondria. Some nice movies of real mitochondria can be found here https://nanolive.ch/mitochondria/. That idea that mitochondria are important for the energy in the cell is still there. Petitio Principii Petitio Principii 2 years ago That the first mitochondria "survived being eaten" is probably a very bad explanation. More likely it was a more complex relationship to begin with, like a mild parasite that evolved commensalism and then mutualism/symbiosis. An organism that' already specialized in "invading" another eventually developing a commensal and later symbiotic relationship is much more likely than just "food" somehow skip being digested and everything still working fine or even better. Bannditbunny Bannditbunny 1 year ago (edited) Thank you for the basic knowledge human that the mitochondria is the powerhouse of the cell 1 Eren Yeager Eren Yeager 1 year ago Thumbnail - The most badass - High-tech - futuristic Mitochondria. Video - 6th grade drawing.🙂 Great knowledge though 🔥🔥🔥 1 Cheemsburger Cheemsburger 2 years ago (edited) Nobody : Schools: Hey did you know that Mitochondria is the power house of cell. 45 The Fandom Menace The Fandom Menace 2 years ago That "first mitochondria" theory tho 😂 Kenneth Bautista Kenneth Bautista 1 year ago Fun Fact: Mitochondria is the Powerhouse of the Cell Kimbal Calkins Kimbal Calkins 8 months ago I recall reading in the book Microcosm that there are cell structures that are not coded in our DNA ? Ricardo N. Santos Ricardo N. Santos 2 years ago pausing the video Before watching the video I just wanna say one little thing... The cell is the power mitochondria of the house. That's it! Thank you! Let's continue watching. resuming 3 ِ ِ ِ ِ 2 years ago THE MITOCHODRIA IS THE POWER HOUSE OF THE CELL 55 SomeoneYouKnow SomeoneYouKnow 2 years ago Keep the science comin plz!! 😁 1 Willy Ajax Willy Ajax 2 years ago What about other organels like lysosomes and ribosomes ? How did they become part of our cells ? 2 Ivan Guthrie Ivan Guthrie 2 years ago Powerhouse of a factory or process plant is called cogen often. Referring to co generation. Co because it is connected to the Grid or a primary power generation plant. Cogen or Gen#. Was a industrial analytical device technician for long time. lolawchoo lolawchoo 2 years ago Whenever I see Mitochondria I always think of the Parasite Eve game and it makes me miss it. 13 Gooner CestLaVie Gooner CestLaVie 2 years ago From our ancestors to future treatments, interesting yes. 1 Kenji Tella Kenji Tella 2 years ago Does this mean that all plants and animals or everything with mitochondria have a common ancestor? Jeremiah Larkins Jeremiah Larkins 2 years ago The first rule of fight club is... Mitochondria are the power house of the cell. 1 d4v0R_x d4v0R_x 2 years ago when i was a kid i was 100% mitochondria 1 Lexi's Corner Lexi's Corner 1 year ago The mitochondria is still the powerhouse of the cell. 1 Burgger Big Burgger Big 2 years ago Actually, mitochondria are the power house of the cell. The singular term of the word is mitochondrion. Martin Picard Martin Picard 2 years ago Increase Mitochondria Function - An Undervalued Running Tool 29,413 viewsDec 29, 2020 613 DISLIKE SHARE DOWNLOAD THANKS CLIP SAVE Amanda RunToTheFinish 15.7K subscribers As we age things change like muscle mass and bone density, but also mitochondria!! They provide the energy you need to run. Here are 6 easy tips you can implement ASAP. HTTPS://www.mitoq.com - Checkout the 400 Independent peer reviewed studies, do your own research and then try it out! This is a partnered post with MitoQ, all opinions are my own. 62 Comments rongmaw lin Add a comment... Thomas Thomas 2 weeks ago The real fun begins in your late 60's. I just turned 72, have been active most of my adult life.... but have had some medical issues in my 50's and 60's. I always took supplements. I began keto 9 months ago. It has been terrific in improving everything. I've gotten rid of body fat, lost 30 lbs, increased testosterone, lowered insulin. I was most active in the 1980's, riding 200 to 300 miles of bicycle per week, for fun. I wasn't training. I just rode, loved hills. I also lifted weights irregularly all along. I'm observing my peers deteriorate from age, most not being physically active, they are falling apart. The smokers, drinker/partiers are mostly dead. The ones still kicking, stay active, but have ongoing issues nagging them. The ones who didn't exert themselves, are gone. I just lost a 75 year old friend who did everything right. He was a marathon runner, ate well, trained hard, took supplements. He died of postate cancer. I'm still upset about losing him. i met him when I was the most active. We lived on carbos. As for myself, I work hard around my abode, but energy wans quickly. I've not done sprints. HIIT looks interesting. I'm about to start hitting the gym again as I need to build and retain strength. As an old man, I need to keep testosterone high, insulin low. With keto, I'm affecting both, but certainly could stand more T. I used Tongket Ali, which helped a lot, but realized that one of its side effects is joint pain. Once I learn that, I stopped taking it. I've been off of it for a week, and things are improving. Time to give fenugreek a whirl. I had blood work done 2 months ago. The doc said my numbers are optimal. I've always had "high normal" blood sugar, and began having diabetic issues about 8 years ago. They are fading with keto. I had a hard physical day yesterday, ate carbos the night before in anticipation of the energy output. I've done this work before, and the carbos didn't help at all. Actually, my energy seemed to fade earlier on.... so I'm sticking with low/zero carb. I will have to give that supplement a go. Stay active. Keep your insulin low folks. 3 Rutger Reddingius Rutger Reddingius 5 months ago (edited) Interesting! 1. Note: before using mitoQ, please know that adverse effects have been reported in kidneys. So, if your kidneys have an issue, first do your own research! 2. As far as I know, humanity lived a few million years without all the (re)fine(d) carbs and sugars we have today. Our mitochondria should be perfectly fine to run on ketones. Carbs have disadvantages these days as they cause insulin resistance. This and the use of seed oils (the poly unsaturated fats that become rancid fast, like canola, soy been, rapeseed, cotton seed, safflour, sunflower plus the margerines etc) which many of use so much, are killing mitochondria. Please don't believe me, do your own research! 😄 25 Sophia Barsoski Sophia Barsoski 4 weeks ago Great video - I'm not a runner but teach fitness to 50plus and wondering about incorporating some sprinting into my classes - what type of sprints? Also what is the name of the supplement ?? 1 danny iskandar danny iskandar 6 months ago Do you do zone 2 training? If yes, in what form and frequency? NOt a doc F NOt a doc F 3 months ago Keep in mind if eat carbs for energy it will be temporally and will deplete thiamine, it's ok to eat your carbs when you have good absorption of nutrients, maybe you are doing all " the right thing " and stll not feeling as good as you should, still losing muscle, still low energy etc...consider that you may be lower in B1 and iron 1 Edward Dean Edward Dean 13 days ago MitoQ is simply an advanced form of ubiquinol. MilkShakeFryDip MilkShakeFryDip 2 months ago I’ve been doing short sprints all my life . No wonder why I look 20 years younger than my age 😆 Jude B Jude B 10 months ago No pyruvate is used not glucose 1:43. Glycolysis takes place in the cytosol 6 Cheryl Allis Cheryl Allis 2 months ago The most efficient way mitochondria creates energy is by using oxygen. At a certain point the mitochondria switches to using glycogen for energy. That process creates more metabolic waste than when the mitochondria uses oxygen for energy. John Buck John Buck 1 month ago Anything on ivermectin improves mitochondrial function? 2 John Gardner John Gardner 1 year ago Finally, someone admits to liking LSD runs! Me too, especially on the trails. 4 Kate Kate 1 year ago What about LHR training and the sprints? I just started this about 3 weeks ago and know I"m not supposed to go over a certain # for my heart rate. Help? Thanks! 3 Amanda RunToTheFinish · Tryhar Der Tryhar Der 1 year ago Great video Amanda. cole alexander cole alexander 10 months ago What kind of sprints do you suggest to do to improve the mitochondrial density? 2 randall hesse randall hesse 2 weeks ago I would need to know what is in it. Donna & Joseph Truitt Donna & Joseph Truitt 1 month ago Look at all the ketosis cultists that know nothing about mitochondria. Your body is literally making glucose through gluconeogenesis with ketones and you’re stressing your liver out by doing so. 1 Design Designation Design Designation 7 months ago Ketones are much much more efficient and leave no toxins or byproducts when used for energy. This is a fact. 20 Paul Sypersma Paul Sypersma 3 weeks ago Its a two way street,fungus loves carbs,as well as fat. Faitdubois Faitdubois 7 months ago Krebbs Cycle all the way! 3 Andrew Finlay Andrew Finlay 5 months ago Restore your glutathione by Dr Micheal Lustgarten.. glycine 7 grams and 7 grams NAC and I added 7 L glutamine I'm 72 and 20% hard...lol... sorry couldn't resist that. ..lol 2 Graham Edwards Graham Edwards 2 weeks ago The best way to increase the number of fully functional mitochondria, is firstly to remove the non functional ones and stimulate the production of new ones. This process is called Autophagy, and it occurs during fasting. Fully functional mitochondria are able to use glucose and also triglycerides to produce ATP, which is the energy source for each cell. Using fats for the energy production is actually more efficient than glucose in many instances. These things indicate to me that the author of this video needs to study the scientific literature and do another up to date version. 1 Erwin Rogers Erwin Rogers 6 months ago Yes 🔥 Chris Lettig Chris Lettig 3 weeks ago Feeling attacked in the first 40 seconds ugh lol CAPTAIN CARIBE CAPTAIN CARIBE 10 months ago As soon as I heard the meow i just knew you had an oriental 😊 3 XGN Glint6 XGN Glint6 1 month ago Hello Can you tell writer down here vi can bay this product? Thank you Foster Scott Foster Scott 3 months ago (edited) Do I hear a Siamese in the background 😁. Great vid. H H H H 1 year ago You are 25 and Look 23 3 gastropodahimsa gastropodahimsa 11 months ago Pure BS. 5 Cell Biology Mitochondria - Jodi Nunnari (UC Davis) 36,304 viewsNov 20, 2017 818 DISLIKE SHARE DOWNLOAD CLIP SAVE iBiology 151K subscribers https://www.ibiology.org/cell-biology... Dr. Nunnari explains that mitochondria are derived from prokaryotes and played a pivotal role in the evolution of eukaryotes. In an aerobic environment, mitochondria produce energy, in the form of ATP. This energy allowed eukaryotes to develop into complex cells and organisms. Mitochondria are also fascinating because they have retained their own genome and are dynamic organelles that communicate with other compartments in the eukaryotic cell. 64 Comments rongmaw lin Add a comment... Michael B Michael B 2 years ago I learnt so much from such a well delivered talk. Thank you. 6 steven Harrison steven Harrison 2 years ago Very well explained, thank you. 4 Erik S Erik S 1 year ago Great talk! You really get taken into the subject by her enthousiasm! 1 Lu Li Lu Li 1 year ago Thanks for your amazing lecture gives us so informative knowledge 1 Michael Harris Michael Harris 2 years ago Thanks for the video, just an interested person in science in general. Seems we have plenty to keep us busy investigating and discovering in the future. 11 evelyne evelyne 1 year ago During mitosis.....what happens to mitochondria ? Do they divide first, then get shared by the two daughter cells? Do they multiply once in the daughter cells ? What is the mechanism of their survival during cell division ? 2 GregMeadMaker GregMeadMaker 2 years ago (edited) Thank you for your wonderful presentation! What have you learned in relationship to the role that the ancient molecule melatonin plays within the mitochondria? -- Audrey 3 Dilipsinh Jhala Dilipsinh Jhala 2 months ago Very good information ! Thank you very much for sharing Boris Petrov Boris Petrov 1 year ago (edited) Outstanding -- I am not at all an expert in this field -- but read all four Nick Lane's book 1 George Armstrong George Armstrong 1 month ago proud to be one of the 36k viewers. thank you for your time and effort educating us. vario laa vario laa 1 year ago Hi Jodi what happens, if you isolate people and poison their mitochondria with e.g. fluoroquinolones in respirators.... and the person doesnt have a chance to come in contact with other people and their mitochondria, so that they can exchange each other and repair mitochondrial damage... just like bacteria do it if harmed with transcription and stuff like this...? Thank you for this wonderful presentation. Danno Danno 2 years ago Quite interesting talk. Thank you. 1 Avi Dey Avi Dey 2 years ago Wow . Very well presented on Mitocondria in humans ! I am interested in finding opportunities for Clinical Studies for developing immune therapeutics for older americans. Examiing now links between Mytocondira Cross Talk with Gut Based Immune Cells. Any ideas for a Clinical Study Design coming out of Nunnari Lab ?? Liborio Quinto Liborio Quinto 3 months ago bellissima lezione - i mitocondri hanno diverse analogie con i batteri: Contengono cardiolipina, possiedono un DNA circolare tutto loro; esprimo 13 proteine che contengono FORMIL-METIONINA, proprio come le proteine batteriche, producono melatonina "proprio come il batterio viola Rodhospirillum Rubrum, hanno una doppia membrana, sono anche in grado di metabolizzare piccole quantità di solfuro di idrogeno, uno dei primi substrati energetici dei batteri primordiali, e vengono riconosciuti come antigeni batterici dal sistema immunitario. Julio Quinones Julio Quinones 9 months ago Wow! How about in plants? Do they form this reticulum? I Sejanus I Sejanus 2 years ago Finally! A YouTube channel for Kreb's cycle enthusiasts! Christopher Ellis Christopher Ellis 7 months ago I assume that there is a rhythm to their action that is concordant to breath. If so, then how one breathes affects their action. Jay Doyle Jay Doyle 4 years ago Very interesting. Thank you. 11 Peter S Peter S 2 years ago Mitochondria are colonized: like workers in a corporation, the perks make it worthwhile to specialize, however, the tools to be independent are lost. 5 Paul Romanowski Paul Romanowski 1 year ago Awesome Video, thx, if Back in school days you thought me biology, I Might have been interested enough to remember This stuff after 40 years...thx again 1 Netto Netto 1 year ago 👏👏👏👍🇧🇷 Hansan Solo Hansan Solo 1 year ago So, Mitochondrias are like midi-chlorians at «the Force»? Hey guys, do you want to train «the Force»? Learn about the mitochondria. Stefan Buscaylet Stefan Buscaylet 2 years ago Great job 1 Dennis Cerletti Dennis Cerletti 9 months ago Not all fatty acids are equal in energy production.Saturated animal fat produces 100% efficiency, mono saturated fat 115% due to the bond opening in the center is a easy snip, now you have 2 smaller sable saturated fats.PUFA's (polyunsaturated fatty acids) are highly oxidative and in metabolizing them produce toxic by-products.Omega 6/ linoleic acid has a 60% efficiency and Omega 3/linolenic acid has 24% efficiency. These heart healthy fats are anything but.Seed oils are damaging energy production from the mitochondria watch YouTube video's of Dr Cate Shanahan, Dr Michael R Eades, Dr Chris Knobbe, Nina Teicholz, Dr Paul Saladino ALEX CIOCCA ALEX CIOCCA 2 years ago Molecular machines and these guys are the machinists Ken Jackson Ken Jackson 2 years ago The mitochondria is indeed fascinating. But it's ironic to hear such a strong sales pitch for evolution using the organelle that so clearly demonstrates intelligent design. For example, consider the proteins. There are a lot of different proteins in the mitochondria. Proteins must fold correctly to be useful and they have to form the right shape and expose the right amino acids at the right places to perform their task. Did all of those proteins evolve? If not, where'd they come from? If they did, then surely there are a fair percentage that aren't quite done evolving yet, that don't fold compactly yet, or that don't fit together neatly with the other proteins components. What percentage of proteins in the mitochondria aren't done evolving? Many proteins have no value apart from being a component in a complex or machine. As the various proteins evolved, why did natural selection conserve them until the other components of the complex completed their evolution? Did natural selection see the evolving purpose? And as each complex in the electron transport chain evolved to functional completion, why did natural selection conserve the whole complex before ATP synthase had evolved into place? The fascination comes from the wealth of molecular machines and their protein components that all function so smoothly to perform such complex chemical processes and even proton pumping. The whole thing is amazingly well designed. 1 ascf2 chen ascf2 chen 1 year ago Appreciated, BLKCZARMEDIA BLKCZARMEDIA 2 weeks ago I have mitochondria is there a way to keep from passing it on to my kids you know since it can cause dementia aida bach aida bach 5 days ago THANK YOU William Domb William Domb 2 years ago Find it hard to conceive we 'consume our body weight in ATP every day' 3 esref celik celik esref celik celik 2 years ago (edited) How could the ancient cells live without mithocondria before they ate(!) one? 2 Max Man Max Man 1 year ago Pls subtitle indo Melissa Rainchild Melissa Rainchild 2 years ago this "schematic"...linking al the metabolisms, is that available somewhere? 3 KlaudiusL KlaudiusL 2 years ago mitochondria is the powerhouse of the cell 3 Mary Ruggere Mary Ruggere 2 years ago Of the eucariots only mammalian mitochondria exhibit maternal inheritance; nonmammalian mitochondria are not maternally so bound. I wonder why??? 1 bodgertime bodgertime 2 years ago I learned you can't talk about mitochondria without invaginated, must mean folds 1 TheFenerbahceSK TheFenerbahceSK 2 years ago 21:15 What are the yellow dots? 1 Malkiore Pretorius Malkiore Pretorius 1 year ago Take a week off. Get online and order 4 things. A playstation 2 - a memory card for it - the game called Parasite Eve - the guide book to Parasite Eve. Then take some time and play this game. I promise you that you will love it. Keith Haken Keith Haken 1 year ago 🤣 bs A mathematical impossibility. Call me for an education. Akira Taira Akira Taira 2 years ago So all by chance...........?!!!!!!!!!!!!!!!!!!!!! 1 Jonathan Brown Jonathan Brown 1 year ago iBiology should remove this video. It is rambling and almost pointless. The presenter night have accomplished good science, but speaking coherent English sentences in front of a camera is a challenge for her. 1 NonYourBuz NonYourBuz 2 years ago ...cross your eyes ?... hraqhraq hraqhraq 1 year ago very generic talk, and mostly about evolution, which is not certain science and un proven, not very useful video indeed Cell Biology: Mitochondria Electron Transport Chain 1,199,569 viewsDec 8, 2016 28K DISLIKE SHARE DOWNLOAD CLIP SAVE Omar Ali 14.4K subscribers The Electron Transport Chain & complexes I-IV that pump protons out of the Mitochondria by the transfer of the electrons carried on NADH & FADH2 to maintain the concentration gradient of the protons "high in the intermembrane space & low in the matrix of the Mitochondria" this video is made by HarvardX on edX https://goo.gl/KDZmML http://bit.ly/2hqwmRB Featured playlist 6 videos Cell Biology: Mitochondria Omar Ali 1,611 Comments rongmaw lin Add a comment... Omar Ali Pinned by Omar Ali Omar Ali 4 years ago also You can watch Videos related to Mitochondria and Electron Transport Chain (ETC) 1-ATP Synthase Structure: https://youtu.be/WzqVu8OWedo 2-ATP Synthase Mechanism: https://youtu.be/39UKSfsc9Z0 3-ATP Synthase in Action: https://youtu.be/A2my52zQA6k 4-Glycolysis https://youtu.be/KfWkZZZjMQE 5-Citric Acid Cycle (TCA) https://youtu.be/82CplqKfw90 175 Omar Ali · TheMindCrushGroup TheMindCrushGroup 3 years ago The fact that this is occurring inside me right now on an incomprehensibly massive scale leaves me in awe... 709 drumphil00 drumphil00 3 years ago That moment when you realize that physics and chemistry and biology really are all the same thing. 1K Luis Fernando Luis Fernando 4 years ago (edited) I've heard all my life that mitochondria are power cells, but never understood any explanation using a book at school, this is mind blowing for me, it all makes sense now. 645 Losttoanyreason Losttoanyreason 3 years ago These animations are so much better than dry words alone on a page . Not everyone is good at mental visualization from a written description. I'm a visual learner and seeing things like this help immensely. 43 DemonizedTX DemonizedTX 3 years ago I cannot believe what I'm looking at. Imagine the people hundreds of years ago making water wheels and windmills had no idea they were copying the micro-machines that make the body run. Incredible! 8 Robert Berman Robert Berman 4 years ago (edited) Excellent! I wish I had had these animations available when I was taking my Biochemistry courses. It would have made things SO much easier! Thank you for the effort you put into these remarkable videos. BB 47 Xezlec Xezlec 3 years ago (edited) This is the best video I've ever seen on YouTube. Seriously. This is what I always hoped the internet would look like... but it didn't. Also, it's pretty funny that you use the word "giant" at the end to describe a mitochondrion. Everything is relative, I guess. 228 CaptnAlex CaptnAlex 2 months ago It’s awesome that time was spent to make these animations and bring clarity to these processes. I think these videos need to be shown in grade school so that kids can be primed to learn how chemistry works later on in higher grades. I'm home With the milk I'm home With the milk 1 year ago Awesome work , this animation is amazing and the voiceover is so good that it feels more like a movie honestly. Truely, good job! Nikos Charalampidis Nikos Charalampidis 3 years ago I feel so grateful to you, guys! I don't want to imagine how much work it takes to create such a beautiful and informative clip like this! Amazing job! 2 Tracy Houser Tracy Houser 4 years ago This visualization seriously is empowering. Taking otherwise abstract thoughts and making them coherent and digestible, and not only that but actually cool and engaging! Jeez, man.. Everyone who was involved in creating and distributing this lesson, thank you thank you thank!! 2 Molecular Memory Molecular Memory 5 years ago Great animations. I'll be using this video with my students. Thanks! 126 Adam Haj Adam Haj 4 years ago The Universe deserves props for every inconceivably tiny structure that operates as a factory. 237 Rylan Anderson Rylan Anderson 3 years ago (edited) The animation and narration made the electron transport chain seem "real" and very understandable. the world is surely better off because of this video. thank you for making it. 2 B D B D 3 years ago This is possibly the best explanation for anything, ever. This is how you educate. 12 TurdFurgeson571 TurdFurgeson571 3 years ago I don't know how to help you if this doesn't make you awe inspired. This is going on in your body right now and is the reason you could even watch and remember it. This is beautiful. Thank you for posting. 3 Locane256 Locane256 3 years ago That was incredible, I can't believe how utterly complicated life is. 19 dos54 dos54 3 years ago Proteins are so flipping amazing. I look forward to the day that we can accurately predict and control protein folding. Imagine that; the ability to create a molecule to catalyze any reaction we could possibly think of. I'm thinking the ability to take CO2 out of the air and very efficiently turn it into plastics or fuels, or the ability to easily turn large quantities of CO2 into O2 for interplanetary travel, then the ability to directly synthesize sugars and foods from the Carbon produced. The ability to manufacture more efficient solar panels. Perfectly efficient recycling of waste materials. Factories that produce no pollutants. Mass production of graphene or carbon nanotubes. The ability to cure any diseases and possibly solve aging. The possibilities are endless! 40 EDUARDO12348 EDUARDO12348 4 years ago Thank you to all the energy spent by those great minds that contributed/ing towards putting together this incredible puzzle. And of course to the people for this awesome presentation. 3 Giovanni Rosado Giovanni Rosado 4 years ago Awesome video, very well explained and detailed. One , if not the best visual interpretation of the electron transport chain. Extremely useful if you are studying the field. Much appreciate, keep up the good work! 1 James Driscoll James Driscoll 3 years ago And I always thought of it as a ski slope, with the chair lift carrying the protons and then skiing down as ATP (basic potential energy transfer). The visualization of the proteins, and their interactions takes my understanding to a new level. Thank you for your work! Noe Berengena Noe Berengena 3 years ago It is astounding that all of this was ascertained by scientists doing research into the workings of our Mitochondria. They were able to figure out the complexity of these interactions operating at a minute scale. 2 Caesar Skiba Caesar Skiba 3 years ago I am at loss of words for how amazing these videos are. Henry Deutsch Henry Deutsch 2 years ago Absolutely fantastic. The animation makes it so much easier to understand. Student A Student A 3 years ago This is a blessing because the only way I seem to absorb information is if I can see exactly what is being described. Thank you for your skills and information! 4 Johnathan Rendon Johnathan Rendon 4 years ago The level of detail added in these animation makes it more interesting and therefore easier to learn. 2 Antony Weber Antony Weber 2 years ago WHO WOULD DISKLIKE THIS? I actually love everyone who made this. It's so much different seeing something happen compared to reading a description in a textbook! L Dewey MD L Dewey MD 2 years ago Wonderful and mind-blowing animation and demonstration of the electron transport chain and ATP synthase! Stumbled across this video while looking up information related to material covered in the book, "The Vital Question", (written by the biochemist, Dr. Nick Lane - a book I highly recommend to anyone interested in abiogenesis, i.e., the origin of life). Great animation!! Sanchari Sanchari 3 years ago This is the kind of show I'd watch. This is absolutely magnificent. I've been struggling to visualize the entire thing, this makes it so easy. 1 Patrick Howard Patrick Howard 1 year ago This is fascinating. Can you include a graphic that explains how we discovered the complexity of how these molecules work? 1 Jacob Lepley Jacob Lepley 4 years ago WOW. One of the best atomic-animations I have seen in a while. Very impressed 3 Daves Reality Daves Reality 3 years ago Insane that this is happening billions of times right at this second in my body. Mind blowing ! Martinius Martinius 4 years ago Wow! Great explanation, and by far the best animation I have seen. Thank you so much! 1 John L. John L. 3 years ago This is like some kind or revolution in the teaching of science. This is cutting edge stuff. And it's being made very accessible to the general public. If I didn't see it I wouldn't believe it. 4 Pramit Jagtap Pramit Jagtap 3 years ago Awesome animation. Really helps you appreciate the beauty of molecular biology. EarthsSaviour EarthsSaviour 3 years ago Awesome video, everything about it: the visuals, explanation, and music! Thank you so much for making these videos. Taha Tantana Taha Tantana 4 years ago I wish i've seen this video before my final exam :3 however it's always a pleasure to understand even a small glimpse of great biology !! 3 Kris Gerard Alvarez Kris Gerard Alvarez 2 years ago (edited) What I have read and reviewed from several chapters of Stephen White's Physiology and Biochemistry of Prokaryotes for several days have been summarized comprehensively in an 8 minute video. Saying that this video is amazing is clearly an understatement!!! 👏🏼👏🏼👏🏼 1 Dialectical Vegan Egoist Dialectical Vegan Egoist 3 years ago Thank you, comrade, really useful for visualizing and interpreting the reaction sequence. 1 Joe Mann Joe Mann 4 years ago I know in detail how this stuff works but never tire of marvelling at it. It bloody maraculous 👍 1 Aliante4 Aliante4 5 years ago This is hands down the best explanation I've seen yet. 3 John Egan John Egan 3 years ago Thanks for putting this together, wonderful graphics and great commentary. 2 Christopher Sibert Christopher Sibert 3 years ago I learned about this in high school, but at the time we had no idea HOW the pumps worked, this is interesting to me for that reason. 3 Ozgur ozgurphotograph Ozgur ozgurphotograph 4 years ago Amazing animation and explanations. Thanks and congrats! 2 Joseph Craig Joseph Craig 3 years ago This video was extremely helpful! Where can I find more videos like this other than the ones available on your channel? BioVisions/Robert Leu/Dave Muzzy Thank you for the upload! 1 jasonE.I. jasonE.I. 4 years ago Wow, I'm at a loss for words! I simply can not comprehend topics like this by just reading a textbook. Animations, however, ellucidate topics and enhances the learning process. Thank you for posting this video. Steve Ballinger Steve Ballinger 3 years ago Incredible how we imitate our own physically visible lives very similarly to how we are made..great vid 2 Brian Foley Brian Foley 3 years ago Wow, that's a great explanation...absolutely brilliantly done. Stewart Elder Stewart Elder 3 years ago Mind boggling stuff, how can you work out what is happening a such a microscopic level ? Very interesting video 6 Basil Labib Basil Labib 2 years ago Thank you so much! I have been struggling to understand ets for so long...this explains it in such a lucid manner. serenityindeed serenityindeed 3 years ago I mean, wow! This helped inspire a new passion for cellular biology in me. Great video! 2 A.I.M.Z. A.I.M.Z. 10 months ago These animations help us to understand and remember stuff better in biochem. Thank u 🌝 santiago diez santiago diez 3 years ago What an excellent video! Really step by step explained slow enough for starters to understand :) Terry Nicol Terry Nicol 1 year ago I just rewatched this video again - gosh it's fantastic. I had forgotten about how How We Make New Mitochondria (Biogenesis Explained) 29,661 viewsMar 25, 2021 1.6K DISLIKE SHARE DOWNLOAD THANKS CLIP SAVE Thomas DeLauer 3.23M subscribers Please hit that red SUBSCRIBE button! Try Four Sigmatic's Lion's Mane Coffee: http://foursigmatic.com/delauer This video does contain a paid partnership with a brand that helps to support this channel. It is because of brands like this that we are able to provide the content that we do for free. Please check out the new workout channel at: https://www.youtube.com/channel/UCQPQ... Please Subscribe to my Email Newsletter Here: https://www.thomasdelauer.com/life-op... Follow More of My Daily Life on Instagram: http://www.Instagram.com/ThomasDeLauer Questions that will be answered within this video: - What is mitochondrial biogenesis? - What is the importance of mitochondrial biogenesis? References https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.nature.com/articles/s4158... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://pubmed.ncbi.nlm.nih.gov/31369... https://pubmed.ncbi.nlm.nih.gov/28675... https://www.sciencedirect.com/science... 150 Comments rongmaw lin Add a comment... Agni Agni 1 year ago Mitochondria Biogenesis is the coolest thing ever. I'm studying to be a chiropractor and I have a degree in sport science, I've been studying the training techniques in Super Training while also utilizing strategic fasting and HIIT. This is the X-factor. Soon as I have my degree, I'm writing a paper on this. 41 Helena Handkart Helena Handkart 1 year ago I've always found the stuff about mitochondria really fascinating! Keep it up!👍 14 Gia Atta Gia Atta 1 year ago Awesome this is a phenomenal visual understanding of mitochondrial My daughter has a mitochondrial disorder. You are brilliant Thomas. Thanks Keep up your amazing job! 14 Josefin Häggström Josefin Häggström 5 months ago Mitochondria are fascinating. So tiny and yet they are everything. ❤ 1 Tomás Tomás 1 year ago I admire you so much. I study nutrition and love everything biology, anatomy, chemistry and researching. But your passion towards research is amazing. Being able to look through so many sources and books and articles, understanding everything, having so much knowledge, that's just great and I wish I was like you some day. That's it, just had to say it 1 Foster Scott Foster Scott 3 months ago Mitochondrial biology is not boring but super fascinating. The shit that happens at microscopic levels is mind blowing. Thanks Thom. Nancy Diamond Nancy Diamond 1 year ago Thomas, thank you for your hard work and amazing information! 4 Domenica Kuwait Domenica Kuwait 1 year ago Love it! One of Thomas's (and in the world) BEST science lessons ever:)) Got smarter and made me laugh..pure genius. God Bless! Jamie Patton Jamie Patton 1 year ago (edited) You are such a good teacher for us visual learners. Thank you 😊 1 C B C B 1 year ago Thank you for making this complex topic so simple to understand. 1 Nikail Singh Nikail Singh 1 year ago The reason we love your videos so much is because you bring in the science your audience is mostly people who love science that's why we're here Anne Makeig Anne Makeig 5 months ago That was a great and very understandable explanation. Thanks so much. DonkeyKong96 DonkeyKong96 1 year ago If you look up the evolution of even how the mitochondria became to be a part of the cell.. that’s some mind blowing stuff 🤯 2 MomSlaz MomSlaz 1 year ago Love, love this explanation! I learn so much, never knew I had so much power! Thank you ! 1 Occio ! Occio ! 1 year ago Wow, im developing passion for biochemestry, thank you THOMAS 😍 4 Violett Fem Violett Fem 1 year ago I started taking ACV every morning last week - 2 or 3 times I had the most amazing energy - it wasn't the same kind/feeling of energy as what I get from my usual 5-6 cups of Coffee. It was amazing :D :D :D 21 Shelby Hall Shelby Hall 1 year ago Yes! I've been studying about mitochondria and the microbiome! 14 Ahmad Awadallah Ahmad Awadallah 1 year ago This vid was awesome! Very clearly explained. 2 S G S G 1 year ago I really enjoy the videos where you concentrate on science! Parenteauxjr Parenteauxjr 1 year ago Mitochondria is the powerhouse of the cell. 40 Holly D Holly D 1 year ago Your analogies are great! 6 v a s v a s 1 year ago I’ve been searching for any info to help/increase my mitochondria! Thank you so much! 1 Victoria Montel Victoria Montel 1 year ago Okay this is a amazing video on who the body works to get enough energy to keep going all day long Christopher Ellis Christopher Ellis 8 months ago Can you imagine if society recycled defective elements? Good SciFi story. berry ardalan berry ardalan 1 year ago Thomas I love this kind of content ... Please provide more videos like this .. nicely done .... Also Can you make a video about prostate and how to shrink enlarged prostate rapidly ... AS always love your show .. 1 Maria Madeleine Maria Madeleine 1 year ago A for effort. 😊 But I understand the science stuff and studies better. Even though I'm not exactly physiologically inclined... 😉 Love your videos, though. 🥰 Love from Denmark, Scandinavia ❤️ Bhryaen Bhryaen 1 year ago (edited) Another thing to note about Four Sigmatic... I get it from Thrive with all their discounts and regular price at about $15 per box of 10 instant coffee packets. I found them at a local supermarket Wegman's for friggin $27. So you save by using Thrive... at least on Four Sigmatic... or not using Wegmans haha EDIT: By the way the "analogy" was a bit harsh. The solution to workplace inefficiency isn't extermination camps... Yeah yeah, I get the idea, but as an analogy... sheeeesh... "And then you just lock those workers up... I mean, they're not doing anything anyway! What?" Andrea Black Andrea Black 2 months ago I like how you jump right into the topic Anne Ribley Anne Ribley 4 months ago This was excellent in simplifying I would more on this and the connection to lipofuscin Alice Gunn Alice Gunn 1 year ago You make it so easy to understand Thou Shalt Not Lie Thou Shalt Not Lie 2 months ago I know PQQ is supplement is something that help with mitochondria. I wonder what other nutropics would also be good for this? Jay Lehman Jay Lehman 1 year ago You had me at mitochondrial biogenesis! 3 Mark Catanese Mark Catanese 1 month ago 28k + people said. Ohhhhhhh but thanks for putting it into laymans terms. You're the best! Erwin Rogers Erwin Rogers 4 weeks ago Love it 🔥 Dj Doolittle Dj Doolittle 1 year ago Thanks for the knowledge :O) Jackie Barker Jackie Barker 1 year ago I’m definitely a visual learner as well. Antonio Perez Antonio Perez 1 year ago Another excellent vid. Have good one everyone. ✌🏾🔥🤙🏾🤗 1 Bennet Blanchard Bennet Blanchard 1 year ago I appreciate your content GM GM 1 month ago Does mitochondria biogenesis mean replacing old mitochondria? Tanow3 Tanow3 1 year ago Are you talking about mitosis, and meiosis phase? 3 Andrew O'Donnell Andrew O'Donnell 1 year ago The Mitochondria is the powerhouse of the cell 2 Sincerely, Kristen Sincerely, Kristen 1 year ago If you're allergic to mushrooms I would imagine you would be allergic to this coffee 😏 8 Jan Lopez Jan Lopez 1 year ago So interesting! Paddy Paddy 1 year ago i think you do a great job explaining everything. you'd make a great teacher. tenure baby. Casey Brannon Casey Brannon 1 year ago Thomas!!! You need to do a follow up video to this one based on this research: https://pubmed.ncbi.nlm.nih.gov/30087348/ "We show here that C18:0 ingestion rapidly and robustly causes mitochondrial fusion in people within 3 h after ingestion. C18:0 intake also causes a drop in circulating long-chain acylcarnitines, suggesting increased fatty acid beta-oxidation in vivo. This work thereby identifies C18:0 as a dietary metabolite that is sensed by our bodies to control our mitochondria." Roshea Roshea 1 year ago I want more energy so I can cast more crykenesis & pyrokenesis in real life Mannu Singh Mannu Singh 1 year ago Please Thomas make a video on how to regrow hair from bald areas on scalp(male pattern baldness) 1 Matthew Alexander Sayers Matthew Alexander Sayers 1 year ago (edited) Methylene blue is supposed it be good for promoting cytochrome C. Miguel mejia Miguel mejia 1 year ago thomas, how does nad and atp play in the role of mitochondrial growth? 2 T T 1 year ago I'm really inflamed and all I want to know is how to reduce inflammation and boost ATP. Lil Crafty Nook Lil Crafty Nook 1 year ago This is fantastic!! One of my big concerns about these vaccines. If that mRNA “genetic material” doesn’t self destruct it will quickly affect the mitochondria. (educated guess?) And that’s not even counting the ingredients in these things!! 2 Suzy Suzy 1 year ago (edited) Anyone know of the best non-dairy creamer that’s not just watery or powder? 1 John Roy Dela Cruz John Roy Dela Cruz 1 year ago Your my science teacher Jeremy Bailey Jeremy Bailey 1 year ago God bless my man! On a fast now 24hrs in let's GO!! 2 Toni Hammock Toni Hammock 1 year ago Ima have to rewatch this later...not in the middle of the night when I'm barely awake because my toddler..😅 Jack Morris Jack Morris 1 year ago How do we maintain optimal health in a toxic environment? Serious question, we are exposed to wifi and cell tower radiation almost every second of every day. What can we do to combat this and maintain better stasis? 4 Sebsatien Dubois Sebsatien Dubois 1 year ago Love this one 🙉😍👌😉 Jonathan Hadley Jonathan Hadley 5 months ago When you've got C.F.S/M.E/M.C.S or F.M this makes it even harder:-( Amber Rose Amber Rose 1 year ago It’s not through evolution, it’s because our body is wonderfully made and designed by our Creator, God. 3 Jackie McAbee Jackie McAbee 1 year ago I think my mitochondria are on strike 😁 DivaEagle77 DivaEagle77 1 year ago Does working out increase mitochondria? 1 Pottenger's Human Pottenger's Human 1 year ago I NEED MORE POWER!!! 1 UMR UMR UMR UMR 1 year ago ...Fascinating!!! 1 A M A M 1 year ago I want to build muscle on keto, but I don't know how to calculate my keto calories and how much protein I need to eat🥺🥺🥺🥺 1 G H G H 1 year ago Thomas needs some chapstick! Amber Rose Amber Rose 1 year ago What’s a typology? Please explain these weird terms 1 Andrew Guevara Andrew Guevara 2 months ago Interesting. William O'Connell William O'Connell 1 year ago Does four sigmatic have any k cups for their coffee? Oscar Yanez Oscar Yanez 1 year ago I love you bro! Ash Khandoker Ash Khandoker 1 year ago (edited) Thomas Delauer I want unlimited energy please and thank you 1 Alexander Farley Alexander Farley 1 year ago Qui-gon Jinn was saying this years ago 1 Excessu Excessu 1 year ago Did you just say mitochondria have Dna ??? 😅 2 John Savage John Savage 1 year ago What about PQQ john mirbach john mirbach 1 year ago 😁🖖✌👍👌😎 Seeyay Seeyay 1 year ago Mitochondria is the powerhouse of the cell. 1 Chris Evans Chris Evans 1 year ago sweet! Steven Forker Steven Forker 1 year ago I barely ever drink coffee. Are there enough benefits to start? California High Desert Preacher. California High Desert Preacher. 2 months ago How long does someone have to fast for, this to happen? No one has answered my question on Stupid tube yet. No one. Richard Rosales Richard Rosales 1 year ago Shiljit. Has fulvic acid pentrates the cell Mmmmm according dr j Daniels tony simon tony simon 1 year ago hahaha! evolution... yeah right! 1 REY GUEVARA REY GUEVARA 1 year ago Yes finally first. Hahaha 🤣 i see why people like to do this it feels good 1 Cindy B Cindy B 1 year ago How long do you fast? viky is here viky is here 1 year ago At first glance I thought it said "mijo" 2 twentyfivekgplants tomake1kgbeef twentyfivekgplants tomake1kgbeef 1 year ago Conquer self lol how about conquer your ego Kim Davis Kim Davis 1 year ago Seriously?!! What is the take away? 1 Clif B. Clif B. 1 year ago DOH theMasterChiefRules theMasterChiefRules 1 year ago No, rube, that isn’t how to pronounce “mitophagy” or “autophagy”. N Avedian N Avedian 1 year ago Yup Jason Lawhorn Jason Lawhorn 1 year ago Say again.. Suziqsnowlite Suziqsnowlite 1 year ago Coq10 ubiquinol 2 Deep Dusto Deep Dusto 1 month ago This was terrible Thomas. Adventure Edgar Adventure Edgar 1 year ago What's up with Thomas's lips??? 🤔🤮🙅 twentyfivekgplants tomake1kgbeef twentyfivekgplants tomake1kgbeef 1 year ago How does it feel to sell your soul to the devil thomas 3 Thomas DeLauer Thomas DeLauer · 04paok 04paok 1 year ago Well unfortunately I’ll be unsubscribing as no response = no care... Autophagy Mechanism | Mitophagy 52,319 viewsPremiered Mar 11, 2020 936 DISLIKE SHARE DOWNLOAD THANKS CLIP SAVE Hussain Biology 169K subscribers Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or dysfunctional components.[3] It allows the orderly degradation and recycling of cellular components. Mitophagy is the selective degradation of mitochondria by autophagy. It often occurs to defective mitochondria following damage or stress. Mitophagy promotes turnover of mitochondria and prevents accumulation of dysfunctional mitochondria which can lead to cellular degeneration. It is mediated by Atg32 and NIX and its regulator BNIP3 in mammals. Mitophagy is regulated by PINK1 and parkin proteins. The occurrence of mitophagy is not limited to the damaged mitochondria but also involves undamaged ones. Autophagy has roles in various cellular functions. One particular example is in yeasts, where the nutrient starvation induces a high level of autophagy. This allows unneeded proteins to be degraded and the amino acids recycled for the synthesis of proteins that are essential for survival. 39 Comments rongmaw lin Add a comment... Kirstin Cook Kirstin Cook 1 year ago I'm currently studying for pathology boards and your videos have been incredibly helpful. Thanks! 6 Hussain Biology Hussain Biology · ifra ifra 4 months ago Please make video lectures on types of autophagy... Like macro, micro, chaperone mediated Autophagy... 🙃 1 Hussain Biology · NickT NickT 1 year ago I have no idea why I'm watching this, but sounds interesting. Keep up the good work! 2 Hussain Biology Havza Imtiaz Havza Imtiaz 2 years ago Your videos based on current research ....and it saves a lot of time to go through the reference books 4 Hussain Biology Hussain Biology · Boy Abdullah Boy Abdullah 11 months ago Assalamualaikum brother. Thank you for this. Could you please make a video about AGEs (Advance glycation end products)? I love your channel and all its content! Much love, from Brunei Jerry Tom Jerry Tom 1 year ago Not sure if I learned anything —- But nice job 2 Robert Smyk Robert Smyk 1 year ago Please explain how autophagy occurs in human cells when nutrition is supplied from the liver even while the person is fasting or starving. manju k Krishnan manju k Krishnan 2 years ago Sir can u make a video on gene for gene concept 1 Ali Baba Ali Baba 1 year ago Your way of teaching is genius, thank you sir. 1 Hussain Biology · Angel Elsa Angel Elsa 3 months ago Thank you 👍👍👍 1 Hussain Biology Shashank Kumar Shashank Kumar 1 year ago I was reading about water fasting and how it activates autophagy. darshika srivastava darshika srivastava 2 years ago Kind of a quick revision... is this the complete pathway including all biomolecules needed for autophagy??? 1 Hussain Biology · Ranjan Ghosh Ranjan Ghosh 2 years ago I went through some videos made by you.. attractive videos sir.. nice 2 Hussain Biology · swagatika senapati swagatika senapati 2 years ago always the best... 2 Hussain Biology · Ana Victoria González Carreón Ana Victoria González Carreón 2 years ago I love your vids!! 2 Hussain Biology · Mehwish Nawaz Mehwish Nawaz 2 years ago Well done 👍👍Hussain biology 2 Hussain Biology · Maria clara Prates Maria clara Prates 11 months ago (edited) thanks!!!!!! this video helped me impressed how creative God is Jesus loves you 2 Hussain Biology · Daulat singh Tawar Daulat singh Tawar 2 years ago Your technic to explain in amazing 2 Hussain Biology · Cynthia Berdeski Cynthia Berdeski 1 year ago .75x playback speed slows the audio making the audio more clear... 1 Hussain Biology · Hosneara Begum Hosneara Begum 1 year ago Muslims all over the world do fasting for a mounth in every year. They do fasting from before sun rise to sun set. From 1400 years ago Islam started the fasting. 5 Hussain Biology loyal4 the way loyal4 the way 1 year ago Man i need to eat less and fast 2 Hussain Biology · Mainul Haque Mainul Haque 1 year ago Islam say "you must have do fasting" Hussain Biology · Art of Meditation & Wellness Art of Meditation & Wellness 1 year ago We are live right now 1 Hussain Biology iamrichlol iamrichlol 1 year ago can't understand what hes saying 3