REVERSE AGING: Sinclair with Dr.Rangan Chatterjee

REVERSE AGING: What To Eat & When To Eat For LONGEVITY | David Sinclair 797,525 viewsOct 13, 2021 Dr Rangan Chatterjee 435K subscribers Subscribe to Friday Five for my popular weekly newsletter - my tips, my experience, my inspiration, what’s working for me. A high five from me to you: https://drchatterjee.com/fridayfive My guest today is a revolutionary thinker and ground-breaking scientist who’s on a mission to make you younger. He’s Australian biologist and Harvard professor David Sinclair, author of Lifespan: Why We Age – And Why We Don’t Have To. David is one of the world’s leading scientific authorities on longevity, ageing and how to slow its effects. #feelbetterlivemore ---- Connect with David: Instagram https://www.instagram.com/davidsincla... Facebook https://www.facebook.com/davidsinclai... Twitter https://twitter.com/davidasinclair Website https://www.doctorsinclair.com About David https://sinclair.hms.harvard.edu/peop... David’s book: Lifespan: Why We Age – And Why We Don’t Have To https://amzn.to/3iQsHi8 #feelbetterlivemore #feelbetterlivemorepodcast ------- Sign up to my new newsletter - Friday Five https://drchatterjee.com/fridayfive Feel Great Lose Weight is now available to order in the UK https://amzn.to/2W6bsOE and in the US & Canada https://amzn.to/2GWPgls Dr Chatterjee’s book Feel Better in 5 is out now in the UK https://amzn.to/2G0XK7l and in the US and Canada https://amzn.to/2EB2oM0 Order Dr Chatterjee’s book The Stress Solution https://amzn.to/2MZ8u8h Find Dr Chatterjee’s 4 Pillars of Health in The 4 Pillar Plan available via http://amzn.to/2yGfpuB The US version, How to Make Disease Disappear is available via https://amzn.to/2Gj1YEL ----- Listen to all previous podcast episodes on https://drchatterjee.com/podcast or via these podcast platforms by searching for 'Feel Better, Live More'. Apple Podcasts - https://podcasts.apple.com/us/podcast... Acast - https://www.acast.com/feelbetterlivemore Stitcher - https://www.stitcher.com/podcast/feel... Spotify - https://open.spotify.com/show/6NyPQfc... ----- Follow Dr Chatterjee at: Website: https://drchatterjee.com/ Facebook: https://www.facebook.com/drchatterjee Twitter: https://twitter.com/drchatterjeeuk Instagram: https://www.instagram.com/drchatterjee/ Newsletter: https://drchatterjee.com/subscription DISCLAIMER: The content in the podcast and on this webpage is not intended to constitute or be a substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay in seeking it because of something you have heard on the podcast or on my website. 1,658 Comments rongmaw lin Add a comment... Neville J Neville J 10 months ago I’m 67 and have been following similar principles for quite some time and I’m still running 3 times a week and weight training about the same. I don’t seem to have lost a lot of strength and am running well. I really don’t feel a lot different to what I did in my 20s. 609 R K R K 10 months ago I've been listening to and following the work of David Sinclair for over 4 years. This is the single best interview I have heard him on. Well done Dr. Chatterjee!!! 255 k boy k boy 9 months ago David please keep encouraging people to quit smoking. I saw an interview with you 2 years ago and I'd like you to thank you for inspiring me to quit. I have 2 young boys and thanks to your generosity in sharing you're awful experiences losing your mum my boys won't go through that. 2 years free of cigarettes and delighted. Huge thank you for everything you do!! 140 linsilu2 linsilu2 6 months ago Thank you for this awesome interview. I’m definitely going to read his book. I’m vegan since 5 yrs now and 3 months ago started on my raw whole plants no gluten, no sugar, no alcohol journey. (I may include some red wine after this interview). I recently completed my 1st ever water only fast (5days) then green juice fast, green smoothies, and now back on to raw whole plants. Just need to get more active with some out of breath type of exercise, and I’m on route to my healthiest life staring in my mid fifties, wish I’d started decades ago! Feeling vibrant and stopped what was the onset of painful arthritis in my hands in just the first few weeks! Highly recommended it! Thank you 🙏🏽 David for your work. 56 Vivian B Vivian B 7 months ago I absolutely love this guy! He is a BRILLIANT man! I’ve been copying the protocol he’s been doing for about a year. I’m 44 and everyone thinks I’m 30! My two sisters saw me at Christmas and were like “how do you not age?” 145 Susan T Susan T 9 months ago In my 20s I decided to eat well, take vitamins, exercise .... I've made this huge investment in myself from a young age with the thought that I'd be happy I did by the time I reached 60. Well, I'm over 60 now and it has paid off, and with talks like this and learning about intermittent fasting, keto, insulin resistance, better exercise/training, I've decided to UP the game. I do not listen to naysayers .... they are downers and not part of the solution. Most people think I'm in my 40s. That is not my genes or random. Do not think or do as the "world" does and the benefits are tremendous. THANK YOU for this great talk!! 271 Meg Garstang Meg Garstang 6 months ago Incredible conversation! Just ordered Dr. Sinclair’s book. I already eat infrequently and I take Pilates weekly with a trainer. I’m going to be 70 soon and I have no physical limitations and take no meds. I had no idea retirement could be this exciting. 188 Lloyd Binen Lloyd Binen 6 months ago Great interview. At 1:20:01 the host mentions a critical issue I had to discover myself in videos like this one. My A1c has been 5.8-5.9 for at least 40 yrs. (I’m 73 and getting forgetful) and called “normal”. I wasn’t really informed about the risks to my cognition that are strongly associated with (and probably caused by) insulin resistance and high glucose until I started watching DS and Dale Bredesen. Better late than never, I suppose. 23 Gk G Gk G 6 months ago Absolutely fantastic interview. You asked all the questions I’ve had in my head. You are a credit to your profession. I wish you were my doctor. 25 Pooja Goyal Pooja Goyal 9 months ago What a revolutionary interview, absolutely mind blowing. David's vision and passion shone through in every word he said besides loads of intelligence. I was teary on occasions esp when David's spoke about loneliness and the importance of having a family, his optimism and simplicity is inspirational.And Dr. Ranjan asked such intelligent questions.....I am truly speechless at the content and the way this interview has been conducted. Thank you both. Namaste! 51 Mrs Lovetomatoes Mrs Lovetomatoes 10 months ago David Sinclair is my hero. The work he is doing will be much more appreciated later. Wishing him long healthy years. Thank you so much for such a remarkable guest 👍👍👍👍👍👍👍👍👍👍 51 Kate M Kate M 1 day ago I wanted to thank you and Dr. Sinclair for this. My mother is in her 70s and has never taken care of her body. She smoked and drank for around/over 45 years and never did physical excersize or ate with any kind of nutrition in mind. After several surgeries and a lupus diagnosis she's been declining quite rapidly - no energy, pain depression etc. None of her many doctors seemed able to do anything that helped. I was watching this podcast and my mother happened to call crying because she felt "like she was fading away and wasn't going to wake up one morning" - I asked her if she'd be willing to try taking a couple of supplements every day for a few weeks to see if that would help. We ordered some NMN and reversitrol and she started taking it. Within a few days she started feeling better. A week in she could do basic stuff around the house that she hadn't been able to do for years. All this without feeling dizzy during and exhausted afterwards (which any sort of basic movement did for her). My mom is insisting that this protol has saved her life, which may be hyperbolic but it is huge for her and I'm so grateful that I found your podcast and this information. I'm now reading Dr. Sinclair's book and will be incorporating some of the supplements into my own life. Joshua Slokum Joshua Slokum 4 months ago Thank you for this superb interview. I’ve read Lifespan and have been an avid follower of Dr Sinclair. Currently I am following many of his recommendations.... fasting, keto, supplements such as NMN..... After 4-5 months of this I feel healthier, look healthier according to my wife and others.... 6 Luella Ventress Luella Ventress 6 months ago Fantastic interview. Well done. David Sinclair, thank you so much for your interest in well being on every level. You've become my most recent, favorite teacher. Rock on 9 Cheryl Anne Cheryl Anne 4 weeks ago I love listening to your interviews because you always have the most thoughtful questions! The guests clearly feel the same. You're awesome, thank you!! 3 Toni NEWCOMBE Toni NEWCOMBE 5 months ago I am 74 Have practised intermittent fasting for over 20 years. Walk 6 klm 5 mornings per week, excersise using weights daily .Height 5ft 6in Weight 60 kilos Feel great, Sleep pattern is a solid 7 to 8 hours. Healthy, Happy , and Stress free. Spend quality time with my 5 grandchildren .. My husband died aged 35.. After which I was motivated to live a Long and Wonderful life… Bottom line.. I have NEVER been ill in my life.. and I Live a wonderful life in Australia.. David Sinclair is an exceptional and amazing man who I admire greatly.. Thankyou Dr Sinclair for sharing your exceptional knowledge …Mimi … 57 Felix R. Felix R. 3 months ago I've seen 3 or so interviews with David, but this one is by far the best! Great subject-specific as well as personal questions! 4 CQT CQT 6 months ago (edited) I like the futuristic doctor's visit: very streamlined, with technology removing the guesswork & adding more concrete data to go by. Also, getting doctors trained in nutritional & lifestyle skills they can then pass on to their patients. Some of the plant-based diet docs have had problems with pushback from the meat & dairy industries, however, so that will have to be dealt with. 12 Michelle Leppard Michelle Leppard 4 months ago My grandma is 94 and my grandad is 96. They have never over eaten and only really eaten whole foods. Though they grew up on beef dripping and lard they ate plenty of vegetables. My grandma has no problems including no arthritis! Both have their sharp minds. My grandads body has let him down but that’s more to do with him being super fit throughout his life and injuries because of it. 11 SM Margret SM Margret 6 months ago I am reading David Sinclair's book at the moment , almost finished, and was pleasantly surprised when I saw him being interviewed here. The medical world is totally outdated and I love the idea of doctors taking a wellness approach instead of a sickness one. Hope physicians will read his book and perhaps change their mindset... 10 Idealistic Idealistic 3 months ago Great interview! A lot of thought-provoking questions. Thank you so much for making this information available. I read the books years ago, and I can say in one of the best books I have ever read. 2 Meem Aly Meem Aly 8 months ago Dr Rangan you nailed it in this amazing interview with prof. David. Asking the right questions gave us a chance to receive massive important information. 26 Alex Wilson Alex Wilson 10 months ago A great interview, I've listened to many of Dr. Sinclair's talks and this is the first time he's actually been asked the questions I care the most about. 42 911susieq 911susieq 7 months ago Fabulous! I am 77 and so passionate about all that Dr Sinclair and Dr Fitzpatrick along with many informed epigenetic Dr’s are helping people live longer healthy lives! Please continue to share this eye opening way of life. I am engorged in studying! I love life and the education that I am getting. I have taught nutrition for years and now a whole new eye opening advance to study and share with others.🙂🙂🙂 10 Nancy LoveLeafyGreens Nancy LoveLeafyGreens 5 months ago Excellent talk, I'll be following this thread! I've been aiming to live well to 150, ever since changing my mind while reading the novel "Jitterbug Perfume" by Tom Robbins. Lovely to learn about continuing longevity science developments. Gardening has saved my life and gives me much energy and so many benefits. Adding what I can do naturally to learning from rejuvanation techniques. Cheers! 3 Lina AbouDheir Lina AbouDheir 10 months ago (edited) Fascinating interview & discussion thanks soooo much Dr Rangan , a spot in lots of questions , very kind of Scientist David Sinclair yo respond soo openly Lots of takeaways Even on life, 👌👌🥰 much less suffering & more Joy & Happy , I hope Covid has taught how to look at life and humanity 💕 15 Paula M Wolter Paula M Wolter 6 months ago Totally awesome, thank you both, it was a privilege to listen to this informative and inspiring interview. Thank you ❤️ 10 Sally Lloyd Sally Lloyd 10 months ago This was fascinating, brilliant interview and loved finding out all about David Sinclair, what an intelligent and lovely man with so much wisdom to give. 44 Gordon Smith Gordon Smith 10 months ago One of the best interviews I have watched. Thanks so much, Dr Rangan, for giving us this amazing ew research from Dr Sinclair. 21 Bhvn Raju Bhvn Raju 10 months ago Very THOUGHTFUL conversation keep going mr DAVID and DR CHATERJEE 🙏🙏 24 Jen Jen 10 months ago I work for a local Age UK and we had a lady that started learning to use a computer in her 80s and then she volunteered for us until she was in her early 90s teaching older people computers. She loved it. She said she lived for her computer class. 106 720 Zone 720 Zone 2 months ago I'm so into David's message now. I've been a 20 year proponent of Dr. Sears' zone diet and other teachings (Omega/Fish Oil - Anti Inflamation). I've now been fasting for 3 months, and am practicing exaclty what he is: I fast 18-19 hours, have all of my calories between 6 and 10pm. I feel excellent all day long. My big frustration: I've always very much trusted Dr. Sears, but he strongly argues against intermittent fasting! I need a live debate between Dr. Sears and David Sinclair - MAKE IT HAPPEN! :) - Thanks for posting this. 1 Parvathi Tiruviluamala Parvathi Tiruviluamala 9 months ago (edited) I always love listening to Dr. David Sinclair. And this was no exception. I have a question. David mentioned that NMN causes proliferation of blood vesseIs in muscles. I am a diabetic with diabetic retinopathy. Can NMN worsen that ? Thank you. I started watching your youtube channel very recently Rangan , and am really likimg what I see. Best wishes to both of you. ❤❤ 17 craig Elmore craig Elmore 5 months ago I love David’s honesty. Stop smoking, stop drinking and don’t be lazy and eat well! Not to mention what a genius! 4 LE LE 6 months ago (edited) My A1C was 5.8 in 2018, doctor said, “you’re healthy”. In 2021, my A1C was 5.7, FBG was 85, doctor said, “nothing to worry about” but this time I did more research. I realized I don’t need a “doctor” to tell me what I need to worry about and do something about. I bought a blood glucose monitor and started testing to learn what foods do to my blood glucose (no doctor ever even suggested to do that), lost 20 pounds, and started watching a bunch of YT videos. I now get my own test via Everlywell…last A1C was 5..6 and it’s going to get lower because I’m now on a low carb diet and also fasting and that seems to work. Also order other lab tests through Life Extension or directly through LabCorp and Quest. I’m sorry to say this, but I feel going to a GP is complete waste of my time and money. What I have to pay for a copay for a visit, I can get 2-3 tests on my own from the lab directly! If there’s a problem, I’ll consult with a specialist. There’s enough information available now for the layperson, that for those who have the ability to read and evaluate the knowledge, what is the point of going to these general doctors who just go through the motions! 24 Lui Lui 1 month ago Insanely good interview. Dr David Sinclair is wonderful. Imagine being those guys painting behind him and hearing this - your mind would be absolutely blown! 1 📱 Demetri Panici - Productivity / Notion 📱 Demetri Panici - Productivity / Notion 10 months ago "When you arise in the morning, think of what a precious privilege it is to be alive - to breathe, to think, to enjoy, to love." - Marcus Aurelius 593 Sarah Em Sarah Em 6 months ago (edited) On my second ever water only fast. The first was 3 weeks ago and I managed 2 days, before I couldn't do anymore because of fatigue and hunger. This time on day 3 and going strong. No hunger, and no fatigue this time, so I guess I have adjusted to extended fasting now. Plan is to do at least a week this time with medical supervision if I go longer. Feeling great on day 3 actually :) I was 70 kilos overweight when I started and have lost 17.5 kilos in 11 weeks using intermittent fasting initially. Want to clear up the eczma on my leg, and also reduce the stain on my knees and hips which hurt right now. 14 adam day adam day 3 months ago Your videos are brilliant Dr, thank you so much for uploading them. God bless and stay healthy. 2 cearilin dubhlaoi cearilin dubhlaoi 4 months ago I really hope David can achieve everything he says can happen foe the future ..how amazing would this be much respect to you both for this interview 👏 👍 🙌 🙏 so interesting..I had to listen 3 times x 1 Rae Wise Rae Wise 10 months ago So thankful I found this conversation! Bravo, gentlemen! PLEASE keep doing what you do?! 20 Norma Westurn Norma Westurn 5 months ago Excellent interview David has a humble personality and share his knowledge in language that lay person can follow Thanks for asking wonderful questions 3 Love & Money Secrets TV Love & Money Secrets TV 10 months ago Dr. Rangan you are changing the world and you are exquisite in bringing extraordinary humans like yourself to the world. Thank YOU! 6 M Prado M Prado 6 months ago @DrRanganChatterjee and @DavidSinclair Thank you so much for making your cutting edge expert knowledge available. You guys invest countless hours of your very expensive time to freely educate anybody interested in advancing the wellbeing of the human race, and you do it just for the sake of it, with no personal financial gain. Will this time of free education ever end? I don't know, but I feel priviledged to live it now, and eternally grateful to you for it. 6 Maria A Maria A 2 months ago Your guest, dr sinclair, is absolutely fascinating. He is very clear at describing what he needs to get accross. We need more guys like him to be honest. Many thanks for this discussion. Health and long life to you both. 1 Charles Farrell Charles Farrell 8 months ago How refreshing to hear someone giving sound advice and not preaching or telling you what to do!!! 9 Blind Warrior Blind Warrior 5 months ago I have been doing clinical trials for about 31 years I would love to be part of your clinical trials considering that I am legally blind in one eye and have low vision in the other but I have already been implementing some of the fasting intermittent and have been doing my own clinical trials and have seen amazing results just from what I have been doing thank you so much for this video God bless you both stay safe everyone in Jesus name 7 swilda123 swilda123 3 months ago What i like about Dr.Sinclaire is that he always give straight forward answers in all his conversations. 1 Lis Engel Lis Engel 9 months ago (edited) Always very interesting to listen to the research in reversing aging, but I think there are at least two ways of knowing how much life is in your life. Monitoring and mesuring is one way used by science, but there is also the possibility of learning to use your senses and become much more aware so that you can feel your body very nuanced and learn how to optimize your energy - and you can also literally “read the vitality and harmony” of people around you - so I think it should be part of lifestyle Medicine to train body awareness and sensitivity 🙏🙃🌸💗 8 Maria Scoma Maria Scoma 2 months ago I loved this interview and have had a lot of realizations. I wonder what my internal age is. I’m so curious. I’m ordering this book as soon as I’m done watching. 1 Cindy D. Cindy D. 6 months ago When I was a teenager I only ate one meal a day it was a healthy meal and that was all I needed I was slim and fit . I became pregnant at 20 with my son so ate more food and more meals I gained 65 lbs and never took all the weight off I have been a yo yo dieter for 38 years up and down all the time. I have started to skip breakfast and allow myself to feel hunger so I guess it is a good thing . At almost 60 I would like to decrease my eating as I go into my senior years I want to be healthy and fit . 6 Forster Dave Forster Dave 3 months ago I'm 55 and had a blood test a month ago. been following the 18/6 fasting principle. Eat 6 hrs , fast 18 hrs. I have lost 6kg in the last 4 weeks..( was 118kg now down to 112kg). Off the red wine except for 1 night a week. Off the sweets, I don't crave sugar nearly as much as I use to. Doc has said I have a fatty liver, and also high blood pressure, my blood pressure is done 20 points top and bottom. I was 155/95 now 145/85, highest I ever got was 185/110... Now, Im down, down down.. The next blood test in 4 weeks, to check cholesterol was at 7.3 . should be a lot lower by then. Fingers crossed. 3 Karina Bloom Karina Bloom 6 months ago I found this Dr to be so real & honest, a great ability to lecturer & relate to people, no Asperger syndrome in this scientist, great spouse & father Hope to see him in the millennium 3 Cristian A. Cristian A. 6 months ago (edited) Nice conversation! At around 1h (1:01:00) there is an interesting question being asked to which I don’t feel the answer really nails is. The general advice towards fighting sarcopenia is to increase the protein intake, to which David agrees, but then he recommends eating protein with low amounts of leucine (and low MTOR therefor). This is where I get puzzled, as the literature at the moment does seem to suggest leucine is required in order to stimulate muscle protein sintesis, otherwise it does not happen. There is of course leucine in plants, that’s not the contradiction, but how to reduce leucine and still build muscle is not really explained. 4 Dr.Jay's Clinic Dr.Jay's Clinic 10 months ago I've been told that I look young for my age. I'm 40. I thought that it was because my genes. but actually I've been doing almost everything you told in the video 28 spiro malamas spiro malamas 4 months ago Hello Dr. Chatterjee I really enjoy your videos and have learned so much. I have an important question to ask you if I may... Concerning the part in the video that your esteemed guest mentions about controlling the aging process and fixing potential issues before they arise, is there something/anything that I can do or take to prevent my profoundly overwhelming arthritis pain on the top midfoot? I have orthotics and an ankle brace and have had a subtalar joint fusion done last year, but the arthritis has spread. I cannot walk properly on most days and that's with my cane which I've never ever used before the surgery. I'm 57 and I'm usually very athletic up to 4 years ago when these issues first started. Specifically, is there something that I can take to influence gene expression to turn off the pain, or is there a way to turn off the inflammation response to ease or completely stop the extreme pain? If I could just find a way to be able to walk even with the assistance of a cane I would be very grateful and quite happy. The mental anguish of not being able to take care of my errands and shopping etc. is taking quite the toll... Thank You and Best Regards 😊 Jonathan Wright Jonathan Wright 9 months ago This has to be the best interview with Sinclair I have ever seen. Well done and thank you Dr Chatterjee! 9 sally m sally m 1 month ago Wow, what an amazing interview. Truly inspirational. Fart Simpson Fart Simpson 1 month ago Here's a humble theory... I took my Rottie to the vet for his annual check-up, and the vet said he is in incredible shape, but he could stand to lose a couple pounds. I cut back his food by 25%, and what happened next seems to conform with what Sinclair says. The dog eats outside, and in response to a decrease in his daily meat supply, he began eating grass and greens like a starving goat. In other words, the dog's natural response appeared to be to supplement his diet to get a feeling of satiation with huge amounts of greens. Dr. Sinclair says our bodies' responses to starvation are millions or even billions of years old. If a meat-eating animal's natural response to "starvation" is to eat mass amounts of greens, could it not be that after millions of years, our bodies have been taught that getting greens is associated with a shortage of food, and thereby stimulates the production of the stress hormones that prolong life? To put it another way, the greens stimulate the hormones and the "healthy" content of the greens is less a factor than the body interpreting that we have turned to greens as a sign that things are not going well on the food front. Eating greens is genetically a signal of bad times ahead. Just a thought. 1 Annette Cinquemani Falbo Annette Cinquemani Falbo 10 months ago This podcast was an answer to prayer this morning. Thank you. 25 felix lopez felix lopez 10 months ago Absolutely the best interview of Sinclair. Great job! 13 C MATHIYALAGAN C MATHIYALAGAN 6 months ago Sir today only I have viewed the conversation and I am greatly impressed by the high tech conversation and innovative conceptual talk. Thank you sir for giving opportunity to hear such valuable audio. 1 Hill Roberts Hill Roberts 8 months ago No one can reverse aging, rather we can reverse what we have been eating. It's what we eat that helps to stop aging, or what we indulge in. I am 69 now and people are shocked when I tell them because they always say I look 45 years old. 14 Rach Shirley Rach Shirley 10 months ago One of the best conversations with Dr Sinclair; and even watching the painter upstairs wasn't distracting ;-) Thanks Dr Chatterjee! 43 Sandra Phillips Sandra Phillips 6 months ago All the power to you, David and thank you for empowering me Ramiro R Ramiro R 6 months ago Im 53 still in phenomenal shape, have been doing intermitted fasting for over 20 years, I actually jumped rope on LIVE tv for an hour at 47 years old ... 16 James Lemke James Lemke 7 months ago Really trying fasting lately.. After listening to several of his talks, would love to get his perspective on fermented foods and maybe grains.🤔 and I’ll add food quality 4 Rureshi M Rureshi M 4 months ago (edited) Just turned 20 last 4 months and listening to this. Thanks for the info✨🙏😘 2 Eelke Aptroot Eelke Aptroot 10 months ago (edited) Good interview, thanks to you both! Though fasting and time restricted feeding do have benefits according to research by Dr Walter Longo there's no need to do it daily once every 2 months for 3-5 days or so is supposed to be enough to get benefits. If you could get him on for an interview you could pick his brain on the topic. 24 SharinMyJOURNEY SharinMyJOURNEY 4 months ago When I was say 25 to 35, I ate right and exercised daily. Aerobics plus weightlifting and I would do pleasurable exercise on the weekends such as bike riding or mountain climbing. I was diagnosed with RA when I was about 37. I couldn’t walk I couldn’t get out of bed I didn’t know what was wrong with me my feet hurt so bad. Eventually I stopped working out, I change jobs to a sit down job. I really got any exercise. I was afraid of injuring myself and swelling up in my feet my ankles or my wrists. Back then I weighed 120 pounds. I now weigh 206 pounds. I still can’t walk, or I’m afraid to my RA has only increased and gotten worse. Even if I try to use something as small as a screwdriver for two minutes my wrist will swell up the next day. I recently started low carb diet, and I try not to eat until about one or 2 o’clock in the afternoon. Now I just started this last week, and today for some reason I feel worse. I don’t know if it’s the weather, but my body hurts. Do you think I could go to a nutritionist and have him check my blood and do you think he would be able to help me based on what my blood tells him? I wish I had a doctor in the house with me for a bit, I really need help, I am now 59. Joanie S Joanie S 3 months ago (edited) Powerful life changing info. I was not aware that Resveritol (doctor recommended) was not water soluble. Thank you, both! appl314 appl314 10 months ago Crossing my fingers for the joint trials. As a person with osteoarthritis I've been told that I can't even get an mri in the area as I've been diagnosed with oa only thing I can do is a hip replacement...seems barbaric and is definitely ageism. Just think of the change in longevity with just getting seniors mobile again. Current medicine is really disappointing 9 AJ AJ 10 months ago you NEED timestamps on these lengthy podcasts 510 Mel Morse Academy Mel Morse Academy 5 months ago I IF daily but still suffer with IBS and GERD. I am slim, eat mostly vegetables and carbs. Do you think there is a benefit in that sense? I usually finish eating around 8-9pm and then usually don't eat until midday the next day. It varies occasionally but when I do eat sometimes, I get symptoms straight away. 1 Aymez CASTRO BAEZ Aymez CASTRO BAEZ 4 months ago A question: have you thought during the scope of your reversing of aging about reproduction? 1 kickstart531 kickstart531 6 months ago U guys deserve this kind of stuff cuz u work hard. U deserves way to go :) Paul Bennett Paul Bennett 1 month ago Ok I'm finally reviewing "Lifespan Why We Age—and Why We Don't Have To (David A. Sinclair)". The book starts off with stories about Australia, Ashkenazi Jews and the author's miserable grandma. He tells how he traumatized his child over death. His family advice is childish: "Never grow up", his outlook despondent: "the person she truly was had been dead many years." He quotes a Holocaust director, "Every death is violent." A horrible beginning, indicating the author's twisted, secular assumptions. The promotional quotes on the dust jacket are from the usual suspects, so we can expect the usual big pharma garbage. Next he gives a quick rundown on the creation of life: "Organic molecules cover all surfaces, having ridden in on the backs of meteorites and comets." Perhaps his readers are not clever enough to question how the alien 'organic molecules' evolved. But that's irrelevant to the author, who quickly switches to a rehash of DNA science from the 90's, gushing about sequencing machines. Gene sequencers have been shown to be nothing but flim-flam since the DNA and RNA and proteins are matched by virtually linking them in a computer model. The same data can be expressed as thousands of different genetic sequences, each of which can be patented- and none of it means anything because we have no way to determine what the sequence represents or how to synthesize it. The core of the book is a meandering narrative about the author's search for ways to discover the secrets of DNA. His style is remarkably similar to authors who search for ancient Mayan secrets, or Pyramid Magic or alien visitations. The world is a vast cafeteria of data, and these authors tend to cherry-pick the most sensational studies to give the reader a long series of "gosh, ain't nature amazing" moments. The studies cited are of the Time Magazine or Popular Science variety, heavy on outrageous claims, unreviewed by actual scientists and always irreproducible. It's science-lite by Reader's Digest. Finally he states his main thesis, that aging is a treatable disease. The connection to big pharma becomes a little clearer. Can we expect a vaccine recommendation coming? He then mocks the desperate people who cling to his exaggerated claims: "Can you tell me what I need to do to get admitted into one of the human trials?" they implore. This is the superior attitude of the con artist. Continuing the warm-up, he runs through the body of well-known nutritional platitudes, anecdotes and wives tales. He cites fringe theories about 'Longevity Pathways' as though they were proven facts and builds his house of cards on the shifting sands of scientific self-promotion. He begins teasing us with an anti-aging vaccine at about one-third of the way into the book. It was a long, slow journey to get here, and I wonder what he will dissembling about for the remaining two-thirds. He fanboys about the CDC and pandemics, then he descends into science fiction: "We are analog, therefore we age." Are we going to be treated to some transcendence grift? No, all we get is more rewashed stem cell and cancer research from decades past. He actually recommends continuous health surveillance, blood testing and AI-assisted, videoconferenced doctors. In other words, the standard COVID model, including the hard sell on vaccines. Maybe this is a dark joke on "why we don't have to age". Moving on to sell a little pie in the sky, located conveniently in the future, he first threatens us with the dangers of the world, trotting out the failed doomsday projections of the past and (global-warming-like) pretending that they were eerily accurate. "Malthus and the Ehrlichs may actually have underestimated the greater and longer-term risk..." He attacks first-world consumption, parades environmental hysterics, and waxes rhapsodic over the dangers of falling first-world population numbers. "Echoing Fenner’s warnings, Hawking believed that humanity would have 100 years to find a new place to live." This is what passes for a standard freshman liberal education. I'm still waiting for some lifespan-increasing advice. It doesn't look good. The author instead resorts to pleas for funding: "INVEST PUBLIC MONEY TO TACKLE AGING, NOW!" Taking it as a given that his lifespan science plan will be funded, he shifts gears and fantasizes about the future where everyone lives longer. Suddenly I realize that this dreamer is not going to get around to actual lifespan advice. It's a bunch of recycled Green Party slogans and feel-good stories. "We’re going to have to be more empathetic, more compassionate, more forgiving, and more just." It might as well have been written by a 12 year old girl. The author's conclusion begins with some anecdotes about big pharma and big government pork projects and results that "look promising". He tells us about projects that are "helping all of us see and appreciate sex differences" or that study "transparent ocean animals". I don't even get to mock any prescriptions for big pharma drugs or vaccines. He can't even commit to that. He finishes up this horrible book with a list of weak technophile platitudes. "Today I have a hard time understanding how anyone could look at this vast and brilliant army of researchers and not believe that a tremendous change in human aging is coming—and soon." He repeats his call for more funding, and warns us not to block his funding. After figuratively fighting off a strawman faction that is terrified of lifespan increases, the author surprisingly throws in (as if as an afterthought) his recipe for lifespan increase. Turns out it's the standard vitamin regime, eating less, exercising and aspirin. Patting himself on the back for all this genius, he says "I’d love to keep nudging humanity down what I believe is a path to greater health, happiness, and prosperity, and to live long enough to know what path we take." Wow. I feel older already. 2 Kieran Daly Kieran Daly 10 months ago Intermittent fasting worlds very well. I never thought at first I could do it. Now I often have one meal a day. Lots of exercise. No lost of power. Low carb is better for me. I’m 66. I love exercise now. It makes me feel happy. No one seems to mention that exercise makes you happy it’s m[not punishment. 58 ethan abe07 ethan abe07 10 months ago One of the best interviews with David Sinclair...Thank you.. It seems to me though that when it comes to future predictions of how much lifespan can be extended he can not speak freely in public..I m sure privetly he expects much more.. 14 ✨Iris✨ ✨Iris✨ 1 month ago I’ve done this since I was like 17, without knowing about this, or with any intention of it. Now I understand why everyone who knows/knew me back then are so often surprised about my appearance. They say I’ve never changed! 📱 Demetri Panici - Productivity / Notion 📱 Demetri Panici - Productivity / Notion 10 months ago "Very little is needed to make a happy life; it is all within yourself, in your way of thinking." - Marcus Aurelius 98 Wellness Coaching with MAR Wellness Coaching with MAR 10 months ago Excellent 👌 I fast every weekend for 36 hours, I work out only an hour to an hour and a half a week and look and feel better than when I did 10 times as much 10 years ago. I do 5 - 10 min long high intensity intermittent training mixed with yoga. I have lowered my sugar and improved my biomarkers and believe you can age less and I know I would be diabetic if I didn't change my diet. So much to say, but I appreciate this video. Huge fan 26 Ken Carey Ken Carey 4 months ago This follows all the research I have been doing. This ties it all together for me in very simple terms. Thank you Kate Wilson Kate Wilson 4 months ago Aging is not a piece of a cake that you can just ignore. Especially for us women, we tend to look more stressed and weaker as we age. But as science is getting more advanced nowadays, it’s now possible to slow the aging process. Thanks to Dr. Sinclair's podcasts and interviews about the benefits of NMN supplement. It's been my 3rd month now of taking NMN by Vitruvin Nutrition, and I could say that my health has improved a lot. I used to have a poor cardio, but now it's regulated and I feel renewed everyday as my energy level is through the roof! It makes me workout daily. 1 Audrey Hurley Audrey Hurley 8 months ago Thanks! Good content and good questions. It’d be great to have Dr Sinclair on again soon! 3 Patricia Balcazar Patricia Balcazar 4 days ago I totally agree! I'm in a keto diet and I hardly get hungry. I do intermediate fasting with out a problem. Bernard Mathu Bernard Mathu 7 months ago I have been age under accessed all my life. When I was 40 people said I look 20, at 60 said 40. I would agree with them. I looked at the mirror and felt the same. I was a fast runner cyclist and all that. With onset of covid 2020 things have changed. I seem to be going down everyday in every aspect yet I have not been infected most of my acquaintances have. But I feel slower, unhappy and not as excited as I have always been about the future. Now I really look old as per the reflection I see in the mirror. 6 Marcus Micheaux Marcus Micheaux 6 months ago I am 64 and cycle 450km per week & can easily do 200km & have done 400km as a single ride. My diet is similar to David Sinclair's & my improvement in life generally is a joy. What amazes me about the sedentary comforts of Western Life is that people struggle to do 2 hours of moderate effort per week. The few Times that I've had medical checkups, my Doctors have wanted to admit me for my resting pulse of 46. Medical institutions have forgotten what normal good health is. I work as a Nurse and patients with BP's of 130/80 are considered "normal". The Health field has compromised on the basic health guidelines, as an example: 10,000 steps per day is a poor health parameter. 3 Roo the Stew Roo the Stew 10 months ago I have read the book. A bit tough to get through in parts for the layman. However, I did take the advice to heart. Currently taking metfomin, nmn, and resveratol. (As well as the other supplements on his cheat sheet-vitamin d, b 12, low dose aspirin) thanks for the video. Btw, metformin available cheap without scrip in lots of countries outside u.s. 16 Samuel Watt Samuel Watt 8 days ago Anecdote that may be useful for someone: Psilocybin helped me quit my daily smoking habit in a single session. The studies at John Hopkins are seeing an 85% smoking cessation rate with psilocybin too, which is better than with any other treatment known to mankind so far. Marilene Duarte Marilene Duarte 10 months ago I am 67years old...and I have Alzheimer.... I AM SO GLAD TO HEAR ALL THIS PRECIOUS INFORMATION....!!!! 70 Misha Ramage Misha Ramage 6 months ago This is fabulous information. I need to get ahold of the supplement list. Are they listed in the book? Anders Jonsson Anders Jonsson 7 months ago Thanks a lot Dr Rangan Chatterjee for having David Sinclair at Your great Podcast! Unbelivable that 2:hour can pass away soo fast! Soo interesting! 😊👍 1 Brucknerian Brucknerian 4 months ago Very excellent presentation. A three day fast is not difficult, if you put your mind to it. And food does taste better, afterwards. Overeating put your taste buds to sleep. Suz Cost Suz Cost 6 months ago My family lineage on both sides regularly produces octogenarians, nonagenarians, and centenarians. Vegetarians are extremely rare! My meat-eating paternal grandmother died just before her 105th birthday. On my mother's side, the record was her great-grandfather who made it to 108. My DNA results show an extraordinary cluster of genes for extended longevity. I'm 62 and an omnitarian. I'm doing very nicely, thank you, and am usually taken to be in my late 40s. I have few wrinkles and few grey hairs. Humans aren't clones! 6 Janice D Janice D 6 months ago So beautiful how Dr. Sinclair lit up when discussing his daughter Alex. Just priceless! 1 Win Balingit Win Balingit 9 months ago I love Dr. Sinclair!! He is always so beautifully optimistic!!🙏🏽❤️✌🏽 12 jose lopez diaz jose lopez diaz 8 months ago More of this humans please and thanks a lot for sharing such a wonderful information. 1 Emmanuel Garcia Emmanuel Garcia 7 months ago Great interview and discories, really. I started to drink most of things david recommends. Now please explain me how are they going to implement this for every single human being on earth and not create longevity for richs and short life span for the remaining 95%. 1 Walter Jeffries Walter Jeffries 5 months ago There are children who have done intermittent fasting long term. I did. Wasn’t my goal. But studying adults who went through starvation/intermittent fasting as children could be interesting. savage: Jacqueline clarissa savage: Jacqueline clarissa 8 months ago I reversed my age ...when I lived a Naturist lifestyle and sabaticalled in my van for 2 years... Now I get it! Its was the natural gene therapy and micobioum of the beach that fed my body... not everything else I was doing!! Thank God for Naturism!! Thank you for interviewing this guy!! I get what worked for me now!! ...who hoo!! 4 Palobar Palobar 7 months ago Thank you Rangan. Great Interview. I recently started intermittent fasting (IF). Breakfast (oats/nuts) is my favorite meal of the day. Is it ok to start the day with a bulletproof coffee and replace lunch with breakfast (18 hours w/o food)? I would appreciate if someone more experienced on IF could advise. 7 falcon127 falcon127 9 months ago FANTASTIC JOB GUYS!!! THANK YOU VERY MUCH FOR DOING WHAT YOU ARE DOING 4 Stand Up Eight Stand Up Eight 6 months ago Eating less and less frequently is such a pleasure for me. I almost never have a full belly, and if I accidentally do eat too much I immediately walk until I feel better. You should enjoy many hours of pleasant hunger per day. It’s incredibly liberating to realize this, but it does take practice. Just keep at it. 6 Lisa Ray Lisa Ray 6 months ago I’m 55 and did intermittent fasting for a year. I lost 10 pounds and felt great but looked AWFUL. I literally lost all my muscle mass. I then tried to increase my protein within my eating window but the reality is that if you are revising your food intake, it’s going to affect your muscles. :( 3 That Chess Guy That Chess Guy 8 months ago I’ve been trying intermittent fasting by only eating breakfast and dinner but I’ve run into an issue. I need to gorge myself at those two meals to get enough calories for the day. I also vaguely remember you saying don’t gorge yourself. Any suggestions? Nataliya Kovaleva Nataliya Kovaleva 10 months ago Best conversation with D.Sinclair I have heard so far! 10 will twigger will twigger 6 months ago I eat one meal a day on a keto diet and it's amazing. I disagree with their stance on keto being a high protein diet. Actually, keto is about primarily consuming healthy fats and reducing sugar, which they agree with, and done the right way keto is not a high protein diet. 8 Kieran Daly Kieran Daly 10 months ago Excellent interview. Very clear information. Both so precise 4 john holme john holme 7 months ago I eat quite a bit but exercise a lot and so stay within the ideal weight range for my height and build. I’ve noticed when I cut back on calories my brain is a lot sharper! 3 Jeanine DeBruyn Jeanine DeBruyn 7 months ago David Sinclair extremely educational and much confirmation on items I have touched on and believed would make sense Thanks kindly 1 Helen O'Brien Helen O'Brien 6 months ago Whatever David Sinclair is doing he looks incredibly young!! Really interesting interview. Thank you both. 2 D LG D LG 8 months ago The tendency of the medical establishment to only want to treat illness, rather than to promote wellness and longevity is the fundamental reason I rarely engage with the healthcare system in the USA. I got tired of my dr always wanting to put me on treatment medication instead of helping me prevent deterioration in the first place. It proves that the incentive is toward making money and not promoting wellness, so I have decided to take my health and longevity into my own hands, by following the research that people like Dr. Sinclair are doing. Since I started fasting, exercising and taking a few high quality supplements (multivitamin, ubiquinol, fish oil, d3, k2, niacin, magnesium), my health has turned around 180 degrees. I am the same age as Dr. Sinclair (52) and I feel far healthier with more vitality than I did at 40...and I haven't been to see a dr in nearly 10 years. I am planning to add resveratrol and nmn to my supplement regimen, but I am still researching which supplier to go with. I also plan to start getting annual blood testing so I can have that feedback to add to my box of tools. I am looking forward to 100 years! 8 Germaine Newman Germaine Newman 9 months ago In Chinese medicine your digestive power is strongest in the morning so theoretically you should skip your meal in the evening rather than the morning. Also Chinese medicine says to only eat until you're 70 percent full. Seems like some good ancient knowledge there! 18 Andrés Franco Andrés Franco 10 months ago Extraordinary interview thank you ! 9 Bernd S Bernd S 8 months ago Best interview with David Sinclair ever..!! 2 alfie Bayfield Farrell alfie Bayfield Farrell 5 months ago I am 19 and live in the UK and would like to try working towards living this sort of lifestyle. I can skip a meal pretty regularly already and exercise a fair amount regularly (although i think i shold run more regularly too) but dont know how i should get started get started on the life style change. I am not great with schedules and keeping to changes, as with most people i assume, so would like to know if there is any advice on how to get started and improve until i can get closer to a lifestyle described in this interview and how i could help myself stick with the change. Thanks :) Divo Bravo Divo Bravo 10 months ago Great talk. I am on what I consider a Keto diet. It is definitely not a heavy meat diet. It is more about eating lots of green vegetables and colourful salads etc. Dr Berg recommends this diet. I have found that limiting the amount of carbohydrates I eat, keeps my blood sugar under control and I have reversed my insulin resistance. I am now taking nmn, resveratrol and utilise intermittent fasting with great results. 8 Valart VALERIE HOPE BENNETT Valart VALERIE HOPE BENNETT 6 months ago THANK YOU BOTH THIS IS INCREDIBLE LET US DO IT SUCCESS. 2 Ruby Blue Ruby Blue 9 months ago I enjoyed this immensely. Thank you!!! 4 Love & Money Secrets TV Love & Money Secrets TV 10 months ago (edited) Dr.David looks 25! I've been doing intermittent fasting since my late 20's not as a diet, instead it has been just listening to my body and have always eaten until I'm satisfied instead if full or stuffed. In my mind I always think I'm 28 and I feel it has helped me look, feel and behave younger than my peers without a shadow of a doubt. Dr. Rangan you look like your in your 20's too! That marathon is going.to boost your testosterone not to mention.the boost you have received already just in prep for the marathon. 7 Happy Morning Show DWAD 1098 kHz Ms Horizon Chaser Happy Morning Show DWAD 1098 kHz Ms Horizon Chaser 3 months ago i'm 50 years old, i do believed to Prof.David Sinclair of his research. Thank you. MICHELLE RICHER MICHELLE RICHER 10 months ago (edited) Has anyone taken the test to check to see what their biological age is? I would love to do that 15 Reuben Tom Kee Reuben Tom Kee 3 months ago (edited) Dear Doctor... if I may... it seems more like reversing the effects of AGING ....not AGE..... i do believe in Sinclair... control of eating habits is the simple part of a solution that many people feel unable to adhere to... 1 Rachel Jaye Rachel Jaye 10 months ago You’re such a great interviewer!! 11 Love & Money Secrets TV Love & Money Secrets TV 10 months ago (edited) I do the same thing with sleep,I have clients, friends and family in Europe and Australia so often do sessions at midnight since it's 9 am in Europe or 2 pm in Australia so I don't go to sleep until 2,3 or even 4 am. And I always or usually get 6 hours of sleep occasionally 7 hrs. And I don't read emails daily or ever at night. I also actively reduce and relieve myself of stress and negative emotions by brain brushing and keeping good brain hygiene like good teeth hygiene and over all. body hygiene using a neuro somatic method scientificaly proven to work on every body because it's based on the brain's mechanoceptive systems. #PSMOMETHOD and it just takes 3 minutes every morning. Before I lift my head from the pillow I start the PSMO and I start my day so happy an energized! 2 fryderyku fryderyku 10 months ago (edited) In bodybuilding there is a reduction phase in which you consume less calories than you need, with a high supply of protein at the same time. Of course, also in conjunction with strength training. The result is a significant reduction in body fat without losing muscle. So doesn't that look like the perfect approach to what is being said in this interview? 3 Leo Kearley Leo Kearley 4 months ago Plant based protein is based on legumes (pulses, etc.) that have high levels of purine. Too much purine can lead to excess Utica acid and the onset of gout (a form of arthritis). Again, a balance is needed for protein intake, and not a reliance on one type of food. 2 S. Veltman S. Veltman 2 months ago Just watching this now and then I got the information that it is the birthday of Dr. Sinclair today. Therefore: Happy Birthday and many many many happy returns!!! Good that you found a way to make this happen!!! :) Gracey Gracey 8 months ago (edited) Actually, I did read a study which concluded that there is such thing as too much exercise. They looked at the heart muscles of people who ran regularly and found that the beneficial effect of running wears of once the weekly mileage exceeds 25 miles, such that more miles above that threshold was associated with aging heart muscles 3 ekcoylejr ekcoylejr 7 months ago The difficulties with starting IF, i believe, is related to detoxification that occurs when you are in a fasted state. Tiredness is detoxing not hunger, ie. Naked and Afraid. Harry Rcatcher Harry Rcatcher 22 hours ago Thanks Dr Rangan for bringing the truth. Everything we have been told is a lie.. 😢 Fb17 Fb17 10 months ago Does this apply to every body type? As a female I tend to get too skinny if I struggle to eat enough (for example because of an illness) and I already have very low body fat. I can't eat enough calories in one sitting... 5 Monica Stella Monica Stella 8 months ago Thank you for sharing this important information. 1 Dina Jones Dina Jones 6 months ago Was never the usual kid/ teenager , enjoyed proper food exercise /sports/music.had no idea I was a Vegan. Isolated life. Since my mid 20's have read more, have had some great not run of the mill, chiropractors over next 50 years, also did live/ dry blood cell test & ideology. Long term relationship at a health food store. It's all info. Doctors have NEVER been helpful if I had an issue of sorts. It's been by asking question of anyone and evaluating info. Jerome Fryer Jerome Fryer 8 months ago Professor John JP Pinel (author of biopsychology) taught the body was designed to deal with deficiencies. For example, there are 7 hormones to raise blood sugar, and only one (insulin) to lower it. 1 RustyBolts RustyBolts 9 months ago Every good experts I have watched on YouTube (about 10) are dead against high fructose everything even fruit juice other than lemon/lime. Mainly it appears that fructose is toxic to the liver. High fructose corn syrup may be the worst. 10 Anne williams Anne williams 3 months ago For the last few months, I've been taking one tablet each day of NMN-Vitruvin Health supplement. I'm astounded to discover that my metabolism now functions as well as it did when I was a younger. Other outcomes aren't nearly as visible yet, but I saw a significant boost in energy and concentration. I'm going to order another few rounds from their website. It took around just 3-4 days to see a difference. 😇🤩 2 Kamal S Kamal S 10 months ago Hope we can also find out what is the amount of the macro foods he is eating himself. I mean the ratio of proteins, carbs and fats. He touched on it when he talked about the Keto diet but also assumed that Keto dieters are taking testosterone or growth hormones to get more energy. I am not sure if the Keto giving you more energy is always keeping you in growth mode if one is not taking those supplements but i guess he is implying more protein will do that. Also in keto one can replace the carbs with more fat and not necessarily with only meat. 3 Lorena Javier Lorena Javier 9 months ago (edited) Thank you. 😊 Can you still lose weight on IF even when no exercise is involve and not sleeping at the right time? FF Forsyth FF Forsyth 6 months ago Thank you for having Mr. Sinclair on. 1 Yvonne Kiwior Yvonne Kiwi Scientists Uncover How to Reverse Aging 333,004 viewsMar 1, 2022 Sciencerely 46.5K subscribers Scientists have successfully increased the lifespan of animals and there are first studies which describe how we might reverse aging. So how could we one day rever aging? 🔬 Subscribe for more awesome biomedical research: https://bit.ly/2SRMqhC 📸 IG: instagram.com/clemens.steinek 🔬Twitter: https://twitter.com/CSteinek In the 70s, scientists observed that cells only grow for a limited amount of days in the laboratory (Hayflick limit). Over the years, so-called hallmarks of aging have been uncovered. These hallmarks of aging govern how our cells age and we could try to slow dem down to "reverse aging". The first hallmark of aging is mutation. We can acquire mutations by being exposed to UV radiation or certain chemicals or through cell division. Cell divsion also leads to a second hallmark of aging (telomere attrition). Furthermore, our mitochondria start to work less as quality checks do not work properly anymore. The hallmarks of aging are tightly linked to epigenetics. Epigenetics means that we have mechanisms (DNA methylation, histone modifications) which regulate the activity of genes. Epigenetics governs the development of embryonic stem cells into cells of our body but also impact aging. The loss of mitochondria for example is linked to dysfunctional epigenetic layers. As we age, at least three epigenetic modifications namely H4K16 acetylation, H3K4 trimethylation, or H4K20 trimethylation acumulate. The thing is that epigenetics is reversible... so can we also reverse aging? Diets have been shown to slow down (and reverse aging to a small degree). Cells also show less damages in their DNA and we find higher levels of proteins which are found in "young cells”. The activity of mitochondria is also increased if we undergo caloric restriction. Diets also impact the production of sirtuins which increase the lifespan and reverse aging. Different compounts (such as NMN and remodelin) have been shown to improve the epigenetic landscape which might have an effect on reversing aging. Exercise also might help to reverse aging as it helps to increase the activity of mitochondria. Meditation and having less stress also helps to increase the lengths of telomeres which might help to reverse aging. All in all studies suggests that some hallmarks of aging can be reversed so lets see where that goes! 0:00-0:46 Intro 0:46-3:53 Hallmarks of Aging 3:53-6:38 Epigenetics Controls Genes 6:38-8:45 Reversing Aging: what is known 8:45-11:25 Reversing Aging through Diets & Sports 11:25-12:13 My Opinion References: https://journals.plos.org/plosone/art... https://reader.elsevier.com/reader/sd... https://www.frontiersin.org/articles/... https://www.frontiersin.org/articles/... https://www.sciencedirect.com/science... https://www.ncbi.nlm.nih.gov/pmc/arti... https://journals.plos.org/plosone/art... https://reader.elsevier.com/reader/sd... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.mdpi.com/2072-6643/12/4/1194 https://www.ncbi.nlm.nih.gov/pmc/arti... https://onlinelibrary.wiley.com/doi/a... Images: Some pictures were derived from Servier Medical Art by Servier. You can find over 3000 free medical images here: https://smart.servier.com/ Infected cells by Beachfront, CC BY 3.0 Drosophila by Kersti Nebelsiek, CC BY 3.0 Hayflick limit by Azmistowski17, CC BY 4.0 Conrad Waddington by https://www.che.ac.uk/what-we-do/conr... , CC BY 4.0 Breast tissue necrosis by Calicut Medical College, CC BY 4.0 Music: Title: Art of Silence by Uniq https://soundcloud.com/uniqofficial Title: Punch Deck by promoted by BreakingCopyright: https://bit.ly/bkc-ethereal2 (CC BY 3.0) Title: Black heat by Ross Budgen (CC BY 4.0) Title: Filaments by Scott Buckley d (CC BY 3.0) Title: Rudolph by Lukrembro https://soundcloud.com/lukrembo Light Sting by Kevin MacLeod (CC By 4.0) Source: http://incompetech.com/music/royalty-.. . Title: Buddha by Kontekst Genre and Mood: Hip Hop & Rap + Bright Artist: http://incompetech.com/ About Clemens Steinek: CLEMENS STEINEK is a PhD student/youtuber (LifeLabLearner) who is currently conducting stem cell research in Germany. Chapters 906 Comments rongmaw lin Add a comment... Michael Lincoln Michael Lincoln 9 days ago (edited) My mother always looked around 20 years younger than her age. For example when she turned 60 she looked 40 and turning 80 she only looked 60 etc. However as soon as she turned "90" and only a month after her birthday, she aged 25 years in 6 months. It was unbelievable. And at 92 she looked 100. It was psychological. She said "I'm now 90 and about to die". That single thought in my opinion aged her massively. 10 Ben Sk8in Ben Sk8in 3 weeks ago I’ve reversed the effects of aging in myself. I eat closer to source and avoid processed foods foreign to my body. I avoid substance abuse as well since it isn’t a fundamental part of being a human being either. I also believe the mind plays a crucial role in the reversing of aging and don’t acknowledge the stereotypes that society has bestowed upon itself and continues to infect itself with. For example if someone my “age” complains and says I can’t do that anymore I’m too old. I might tell them that’s their problem if they want to believe that because I don’t. I disassociate myself with old minded people as well because I’m not going to have that “I can’t” mentality projected onto me. In other words if you’re “older” you’re probably going to preserve your youth better hanging out with younger more able minded people that aren’t treating you like you’re old. 320 CubaHubbaBubba CubaHubbaBubba 3 months ago (edited) I'm 28 years old, growing up as a kid I always wanted to learn why we age and why my parents got old and weak. Now I'm starting to see myself get older and it's not nice to know that I'm no longer 21 where I didn't care about aging or anything. I researched it all my life and would love to become a professor and help young people becomes graduates in biological science. The more people want to work to eliminate disease the higher chances we will be able to achieve it. I don't want to die at 70 it's early I believe time goes quick and we age quick 145 Dick Kline Dick Kline 2 weeks ago (edited) This is a very interesting video. I feel that there are two vital components that have not been mentioned. First, we are all Pavlovian creatures who have been programmed by our particular life experiences, which determine all of our future choices. Often we make the same bad choices over and over again because we operate strictly from what we have learned. The important thing is to break your programming codes in order to make better stress free choices. Second, everyone carries unresolved anger from childhood injustices and we transfer that anger from the past to the present. This pattern must be broken by resolving the past anger with where it belongs. In the past. The idea is to become free of old programming codes which keep us from transforming into the present and living a more stress free life. In other words, you have to “own” this information in order to employ it. Does this make any sense? 36 Ms Gen Xodus Ms Gen Xodus 3 weeks ago If you are practiced at fasting, it doesn't "feel" like starving. In fact, you have a better idea about how your body is functioning based on your feelings. You know that hunger pains aren't really a problem. It's like getting sleepy in the afternoons, you expect hunger but have ways to push through (such as drinking water with electrolytes) the hunger pains. I've practiced fasting since I was 12 or 13 years old, and it takes a while to get used to, but once you're used to it, you look forward to that fasted feeling. I equate fasting to doing endurance cardio activities. Longer you go, better you get at going longer. 90 Aliciagny Aliciagny 4 months ago Wow, great video! I always wondered why I look so much younger than I am. No one in my age group looks as young and I don't have the health problems they do. Everything you said made me realize why. So I don't just look younger my cells really are younger! That's the best news I had all day! I will keep doing what I'm doing and live a really long time! Hopefully. 💗 38 Sciencerely om1gee om1gee 6 months ago (edited) Definitely an interesting topic. Not to get the chance to follow science (and Sciencerely) longer and see all the fancy stuff from 2100 but also to reduce the chronic pain in the later part of our lives. So yeah, wouldn't mind if you dig deeper into this topic :) 31 Sciencerely Astral Wound Astral Wound 6 months ago Good video. I'm probably in the minority, but I would absolutely let myself be genetically modified to reverse my aging. I'd be first in line for that clinical trial. 324 Sciencerely Trend101Warrior Trend101Warrior 5 months ago The mainstream media needs to get on board with this anti-aging research. Too many people are conditioned to think aging is natural and barely anyone notice it. 132 Lukas M Lukas M 6 months ago "We do not want to genetically modify ourself..." yes we do, at least some. If you have a chronic genetic disease you become quite more tolerant of that thought. 276 Sciencerely Stravo Lukos Stravo Lukos 2 weeks ago At 72, you bet I'm interested in this! We need to do more research trials. Good genes, good food, exercise, & fasting are high on my list, but I know there's more, like good sleep & dissipating stress constructively. I'm just curious about what a longer time on earth might do for some of our greatest & kindest minds. Or will we just become more of ourselves? 9 Dean Christie Dean Christie 11 days ago Yes, I would like to know more about aging slower. I said to myself that I wasn't going to put on weight and I weigh same as 40 years ago. I have maintained my flexibility. I learned Meditation 50 years ago and tai chi and the slik exercises and the Tibet rites 40 years ago. I don't eat foods that are too hard to digest (beef and pork), are too acidic (melons, most fruit), contain yeast (bread), processed food or too much canned food. I don't smoke or don't use drugs. I continue to learn new things. I enjoy examining new ideas. 9 The Clephane The Clephane 2 weeks ago YES! More on aging and stopping aging please! 8 Jon Reiser Jon Reiser 5 months ago Well done. This presentation was not too dumbed down, yet not so overly comprehensive as to be too complicated to understand. I would be interested in another video like this that takes just a little deeper of a dive into the subject. This information has been offered many times on YouTube. I can’t stand to watch the scientist who gets into concepts that require a graduate degree in order to understand. However, I would like to understand more. 8 Sciencerely Mr. V Mr. V 4 weeks ago Great video. I just wanted to say that regarding human diet, fat being the bad guy is no longer true. it matters which type of fats you consume, whether saturated or unsaturated. Also the lobbying done by the sugar companies to discredit fat is a big issue. Sugar, in all its forms (syrups, dextrose, maltoze, maltodextrin and even substitutes like xylitol) should be heavily regulated, yet they are in everything, from sweets to pills to salami. 52 Peter Balan Peter Balan 2 weeks ago I started exercising systematically 3-5 times/week when I was about 60. Today at 75 I exercise 3 times/week and regularly bench press 2 times 5 reps at my body weight of 75kg. I feel great and really enjoy daily life. Importantly, fitness has allowed me to recover very fast from prostate removal, radiotherapy and open heart surgery (mitral valve repair) in the last 4 years. I was never an athletic or sporty person, so you can do this. If you have old injuries (eg from sports), consult an exercise physiologist for advice on how to exercise safely. It is really worth the effort ! 24 Robb's Homemade Life Robb's Homemade Life 2 weeks ago I enjoy your combination of helpful information and sense of humor. I drink green tea and eat a lot of tofu and walk twice a day and bounce on my trampoline and have recently started exercising with some resistance bands. Also my stress levels are very low because I don't plan on dying because my plan is to be held over by popular demand. I subscribed and click the bell. 6 Sciencerely Ed Meyer Ed Meyer 3 weeks ago No alcohol or smoking with weight lifting and proper nutrition, hydration along with constant blood flow throughout the entire body drastically slow the aging process down. 13 DDean W. DDean W. 2 weeks ago To advocate eating "low fat" can be very misleading. The average person needs to understand the difference between BAD fat and GOOD fat. It is VITAL that we eat GOOD fat and avoid BAD fat. 27 J of BEATS J of BEATS 4 months ago Great video sir. I agree with the end part of the video I could see us all probably extending our lifespan like even pass 100 but as for stop aging entirely I don't see that happening. Especially since we all know that nothing last forever in this whole planet yet alone our universe. I think I'm fine with living even with aging, it's a part of life. 6 Sciencerely Olivia Miller Olivia Miller 4 months ago People who say they don't want to live forever should still support this because you can always change your mind later but not if you're already dead. I have been saying this... longevity is our choice! If we want to sustain our health, we have to do something about it! This will start by knowing what supplies our body needs. Start by eating a balanced diet, quit vices, exercise regularly and take an NMN supplement. Mine is a 500mg per day, NMN by Vitruvin Nutrition. The goal should be to live longer while staying young and healthy. Sinclair believes that in the foreseeable future, it's possible for humans to live beyond 120 or even 150, without the frailty, diseases and disability we now associate with old age. See your result and tell the same experience. 11 Jeanne Engebretsen Jeanne Engebretsen 8 days ago I loved your presentation. I have been researching TCELLS. I kinda of understand some of this, but hard to find information. I am now subscribed to your channel. Thank you please recommend books to study 1 Nima Fouladi Nima Fouladi 5 months ago I really enjoy all of your content, please keep it up! 4 Sciencerely kim warburton kim warburton 2 weeks ago there is one factor you missed that im aware of, sleep. A lack of sleep is more detrimental than stress on a cellular level, on an epigenetic level, on a mitochondria level, on a nutrition absorption and waste disposal level, on a cognition level. Im of the belief that it is probably unethical to artificially prolong life with medical intervention. healthy life habits should be the limit. My opinion is likely influenced by kim stanley robinsons' mars trilogy 8 EMiL EMiL 2 weeks ago I would gladly modify my genes or even integrate with a machine in order to live longer. We had a very low chance to be born. Now that we’re here we should want to stay a bit longer. My dream is to live long enough to visit other stellar systems. Thank you for the video. Nothing new but you nicely put everything together. Congrats 6 Andrea Stott Andrea Stott 1 day ago (edited) Very interesting video, thank you 🤩. Just a quick point regarding fats - there's research showing that it's processed food and sugar - rather then fats - that is bad for you. However of course not all fats are equal and some - such as trans fats - are considered bad for you.... Annoying Mouse Annoying Mouse 1 month ago I'm now 35 and I have always wondered as a kid what the point of life was if we just die anyway. Seems more things would get done if we lived indefinitely. No worries about getting old and dying would be great. Maybe our minds would focus on fixing other issues and create a legitimate heaven on earth. 16 wade cooper wade cooper 4 days ago Sincerely thanks, I am 58 and I used to pass for 35, now I am happy to pass for 45, it's catching up with me. I hope that all these innovations will come into book form soon. Kasu Kasu 6 months ago Great video! Keep the high quality content coming! 4 Sciencerely seeker seeker 13 days ago Love to see more on ageing 👌🏽 thanks for your investigation 😃 from Belgium 1 Sciencerely Josh Josh 12 days ago Interesting video. It's no secret that aging can be slowed down by diet and exercise. But, as human beings I don't think it is possible to reverse aging. It is the natural life cycle of who we are. As for being immortal. Why would anyone want to live forever? 5 megatendencias megatendencias 3 days ago This video convinced me to subscribe, it's full of content on anti-aging research. Congrats. BlackShadow BlackShadow 6 months ago Are you familiar with a compound called Resveratrol? Its been shown to activate Sirtuin1 and there are some interesting trials regarding longevity in model organisms. Sadly there are no large scale human trials yet and the overall situation regarding high quality studies is more like meeh... 17 Sciencerely Sciencerely · Ghostpepper Ghostpepper 2 weeks ago Great video, your presentation is friendly and informative. I enjoyed it a lot. 1 Daniel Ben-Avraham Daniel Ben-Avraham 2 weeks ago Or you could just prevent aging through diet as the 80 year old Annette Larkins did. Stress kills and causes aging and the proper diet and lifestyle aimed at physiological stress reduction works better than pills. 5 Nelson José Pérez-Sosa Nelson José Pérez-Sosa 10 days ago Excellent content. Thanks for sharing. Wishing to receive more informtion on these themes. Kudos! evolve evolve 5 months ago (edited) Your channel rocks! Great quality videos. :) Thanks 5 Sciencerely Fluffi Cat Fluffi Cat 13 days ago This is great for me at aged 70 and not feeling or looking it. I've done intermittent fasting for most of my adult life - not intentionally ,but that's how I've naturally always eaten. But .... surely older people aren't really considered necessary to those in power as the world becomes overpopulated and resources become scarce? !! Also, governments do not want to pay pensions indefinitely to old people so they will not be advocating reverse ageing! 3 J Sullivan J Sullivan 2 weeks ago There was a study done concerning VO2 max. It was on police officer candidates. The higher their VO2 max, the longer they lived; regardless of other factors. 4 mrsharbormaster mrsharbormaster 13 days ago I would love more and more reverse aging. Thank You Sciencerely New Channel New Channel 10 days ago Wow. The man who wrote the "No-Aging Diet" in the 1970s was ahead of his time. Dax Dax 2 weeks ago In diet, I heard to cut back on carbs, and up good natural fats. With the added 'D3', since spring, (and others) the improvement I found remarkable. ANY changes to the positive at '70 years I welcome! PS.................IF really works also! 6 Faye Wong Faye Wong 1 month ago thanks for your insights, very interesting and i am sure ur channel will do well with ur great content topics! <3 2 Sciencerely 🌟 Wander the Nomad 🌟 Wander the Nomad 6 months ago (edited) Since we seem to only be able to reduce aging, but not prevent death entirely, I wonder how dying by old age will be like for people who have reduced aging. Will it just be the same as we know it, but just moved later on in time? Will death by old age be more comfortable for people who have reduced aging? Or will it feel the same as normal deaths by old age? 3 MrGriff305 MrGriff305 5 months ago Dang I really hope they bring this to market in the next 25 years. 8 Nemanja 369 Nemanja 369 4 months ago What some people don't understand about reversing aging is not just about extending quantity but rather improving quality of life. I would rather live 90 years feeling like in my twenties the whole time, than to live in pain, lack of strength, flexibilty and energy half of that lifespan.. Only a young ignorant fools or religious fanatics would be against something so good and logical for humankind. 28 Tate Lieurance Tate Lieurance 2 weeks ago If I could live to 100 years buy be healthy the entire time. Then I'd be happy. 5 Fart Simpson Fart Simpson 11 days ago I come from a family where those on my father's side have a history of extreme longevity. For hundreds of years, if they made it past their youth and did not die of TB, they all lived to be over 100, with most making it to 108. This includes a great great uncle of mine who smoked two packs and drank an entire bottle of whisky every day. He died shortly after his 100th birthday. They all look much younger than they are, with those currently in their 80's looking and acting like people in their 60's. My 82-year-old great aunt still goes to the Canadian Rockies every year to ski black diamond runs. My 79-year-old great uncle participates in MMA, works out 2 hours per day, and always does 120 slow controlled pull ups with perfect form every day. He looks like he's 49, not 79. BTW, they are all tea drinkers and naturally fast because they simply don't care about food. 6 J Boutame J Boutame 2 weeks ago I liked the video. I’d love learning more from you. Thanks. 1 Dan Mentink Dan Mentink 2 weeks ago If you eat every other day you get the same effects as fasting, but you can eat normally every other day. So it makes it easier. 6 gotnokittys gotnokittys 4 weeks ago I had a degenerative arthritis since my early 20's. I'd be pleased with normal, but no chronic pain. 1 just thinkin' just thinkin' 3 months ago Great video. Please elaborate on the study on mice. I read that before and it was fascinating 1 Andy Bryant Andy Bryant 13 days ago When my grandpa got older he started listening to this one CD 💿 and he swore it made him feel younger. He had more energy and lost weight. 2 ZEKE ZEKE 2 weeks ago I,m. Almost 70 and feel great,walk with my dogs at there fast pace every morning after lite coffee and a banana and work at a job that tests my problem solving skills every day,for diner its salmon and beets washed down by Fosters beer! I can out work kids half my age without getting winded moving large objects by hand and always avoid doctors medications-they are the killers! Having a great sence of humor really is the key! You gotta laugh to get thru this crazy world of today,if you take it to seriously it will kill you !! And besides it worked for George Burns-he lived laughing to 100 smoking cigars, life long and prosper my friends..... . 6 Francis Marcel Vos Francis Marcel Vos 6 days ago The elements and factors that make us younger were know already from studies of centarians in the mountains of the Ural and in Japan. I read about them in the eighties in the newspapers that I read. Natural food, little meat, excersize, little stress, little medicines, good genes, little alcohol, no drugs, good social contacts and no environmental polutants. I live in the Netherlands, one of the most poluted environments in the world. That subject may bring our government down in the near future as our farmers and industrialists still don't want to change their way of production. I still await for news that there are other factors that will prolong life. If you have, please let us know. TWO BROTHERS KAYAKING TWO BROTHERS KAYAKING 11 days ago People often tell me that I don't look my age. So, I look and feel younger. Probably genetics helps. I also don't stress out or worry about life (or death either). I love kayaking but not the slow boring stuff. We do whitewater! We go right into rapids and waterfalls (not really big ones like some of the pros) and if we get tipped over, we just roll up, lol. LOVE IT! I plan on doing that past 100. (If you want to check out some of our experiences, I'm at YouTube, TWO BROTHERS KAYAKING. I do smoothies with fruit, raw honey, cinnamon, cocoa, turmeric, moringa, matcha, chia seed, spirulina, aloe berry juice, and sprouts (I grow my own broccoli, radish, clover, and alfalfa). I'm enjoying one right now. I mostly eat salads (with my sprouts added), wraps from Subway, and grilled salmon seasoned for taste. Occasionally I might get Chinese (shrimp or sesame chicken). Yesterday I used my chainsaw and tractor to carve up and move a large box-elder that fell over in my back yard. I supplement heating my home with firewood in winter. I get logs then cut and split it myself. I turned in my tractor-trailer a month ago. Driving in Mass, NJ, NYC, etc. was getting too hectic and way too stressful. Enough of that. Instead, I took a position with a local trucking firm as a Driver/Instructor. Home daily by 15:30 and no OTR. Zero stress and I just let the students drive now and I just ride. Sweet! I plan on retirement in about three years. So, thanks for the informative video. I very much interested in not aging and even REVERSING AGING!! Friggen' awesome!! Oh yeah, I'm 67 years young!! 1 Freya_Zoe C Freya_Zoe C 12 days ago fantastic video, informative, but well explained to the average joe...😀 Raj Sakaria Raj Sakaria 3 weeks ago (edited) Anthocyanins boost deacetylation. Sirt6 is for dna/telomere repair. Sirt1 is for inflammation 2 Gregory Malchuk Gregory Malchuk 6 months ago There needs to be an Apollo Program/Manhattan Project level crash program to develop life extension technology. Though first I suspect we are going to have to force society to view aging as a problem in the first place. You can't solve anything if you can't identify and define the problem. 14 MXQ TV MXQ TV 2 weeks ago The important thing it's to age healthy because everything needs to die eventually so others have their chance to live like we did. 4 Larry Strayer Larry Strayer 2 weeks ago Fasting with meditation feels like one is revitalizing oneself. I practice it weekly Sunday-Monday 48 hours. 2 AR H AR H 2 weeks ago we're not mice, we have much longer life spans and the trajectory of cell regeneration is different. Taking the mouse model for longevity and applying it to humans can be a huge mistake. 4 Dr. Jagdish Khatri Homeopathic & Science Dr. Jagdish Khatri Homeopathic & Science 12 days ago Nice well explained and very knowledgeable sunnydey sunnydey 1 month ago Ok, I must admit those scientists begin to sound like our parents. They must of knew what those scientist have discovered. 2 Steven Grammer Steven Grammer 11 days ago Thank you for the video on reverse aging.🌎 Odessa Smith Odessa Smith 6 months ago So if red light therapy causes cell division, which the makers of the panels promote as a good thing, why would it not in fact actually be a bad thing as too much cell division or premature cell division is actually a sign of ageing? 4 Sciencerely · cheri lynn fisher cheri lynn fisher 12 days ago "Just because we could doesn't mean we should. . ." --- Ian Malcolm This is the stuff that fuels an ethicist's nightmares! Twelve Tenth Twelve Tenth 3 weeks ago Entropy is ruthless. But our cells fight it. It is almost a miracle that such complicated life systems like us proceed to exist. Permanent youth feels somehow easier than reproduction, but apparently it is not. Strangelly, in nature reproduction ended up as a necessary method for evading the entropy of time. But now we want to save the individual, not only his genes and species. 1 Brett Moore Brett Moore 10 days ago Could be simple as we live in a ravaged world that once had higher atmospheric pressure. I believe that long time ago we had larger trees that drank the water table down and respired it back into the atmosphere until something happened to the colossal trees of old. Nonpareil storyteller Nonpareil storyteller 2 weeks ago Niacin, vitamin B3, the non slow release version. Excellent support tool in addition to diet and exercise. 1 Tomken8d2 Tomken8d2 2 weeks ago HDAC-1 and hyperbaric oxygen treatments are two of various ways to reverse aging. 2 PeladoClaus PeladoClaus 2 weeks ago Bad genes don't cut on without environmental inputs. This is epigenetics. 4 TheSunnySide TheSunnySide 2 weeks ago this was hard core nerdy but I super loved it & appreciate all of the information + great video as well - Tnx S 1 Sciencerely Fatima Lopes Fatima Lopes 12 days ago More of this videos. Thank you. The Lost One The Lost One 11 days ago Yes more age realted vids please. MidMo 4020 MidMo 4020 1 month ago My dad used to say about his Bday “it ain’t the years, it’s the miles that take their toll”.. I never understood that until I turned 40.. 6 Jo In Jo In 13 days ago I'm a functional alcoholic. In my late 50's. I no longer really care how old I get. In the end, we all go; doesn't matter. Some of us stay awake longer than others, does it really matter in the end? 2 Brother Carlton Brother Carlton 2 weeks ago The apostle Paul spoke great wisdom when he said: "For me to live is Christ and to die is gain." Philippians 1:21 4 boy Afrika boy Afrika 2 weeks ago (edited) Everything has a beginning, a boom and a fall. Death is the pinnacle of all of all living beings. Aging is part of that, the easiest way to explain is the gravitational force. When you're born, you're too weak to go against it. which is why you crawl, as you get stronger you are able to stand, run, and for super athletes they are able to defy it for few seconds. As you get older you body start feeling it, by developing wrinkles as if your skin is pulled down by gravity and it also becomes less elastic, until the gravity even bends your spin, you start using a clutch to walk around until one day you can't fight it any more and lay down, so your soul can ascend to the next realm. 2 Mainstream Mainstream 2 weeks ago Does living healthy mean my mitochondria wouldn't shut itself down as I get old? I thought I would still die because my body would shut itself down. 1 Shekhar Mohanty Shekhar Mohanty 2 weeks ago we need more info ... more things,,, and specific steps so that its doable for common people like us who understand less of medical jargon and more of "what the hell bro" stuff ........... I subscribed you bro.. looking forward for more useful info 1 James Barisitz James Barisitz 2 weeks ago If you make more videos about aging, I'll watch them. If I'm still alive. ✌ 1 SuperBigwinston SuperBigwinston 4 months ago (edited) What about serious brain damage that happened 25 years ago. Could that be reversed and cured. 2 meyersonfire meyersonfire 2 weeks ago I don't want to live on this planet for any longer than I have to. There's a better place out there--I'm not from here, and am happy to learn my lessons here, but the other side is my real home, where I really belong. More beauty, more love 3 Dennis Burton Dennis Burton 11 days ago How old would I be if I didn't know how old I am. Before calendars,time & watches people just lived without being obsessed about age. So I've decided to be half my real age. 1 TheMarioMen1 TheMarioMen1 11 days ago Mid 20 something now and had seen a video by sci show I think about regrowing a human liver from some batch of cells, if that proliferates who’s to say we’ll fix aging by regrowing all our organs and having them replaced periodically, every 80 years or so? 🤔 1 Satya Supteshu Jagarti Satya Supteshu Jagarti 5 months ago Yes please continue this series 2 Walter Jeffries Walter Jeffries 2 weeks ago Not everyone ages like you describe, of course. You speak of decline with age. But I am not seeing it in myself. I physically still feel about the same as I did at age 25. Yet, I am 60 years old. Last fall I fell off the roof 25’ down to concrete. Backwards swan dive. I flipped over in the air and landed on my feet. Walked away from it no problem. No breaks. No sprains. No damage other than a scrape on my arm where I hit a 2x4 on the way down. The 2x4 broke, I had grabbed it as I went by, so it absorbed a little of my energy. This is normal for me. I am agile and virtually always land on my feet. I tend to jump off stuff too as a way to quickly get where I am going but that time was a genuine fall. I have fallen a few times in my life as far as 70’ but onto dirt. No injuries. Interestingly, my BMI is very high but that is likely thicker bones and muscle. BMI was designed around office workers who typically have a very different body composition due to activity levels. Additionally, I am usually carrying around 20 to 40 lbs of tools, sometimes twice that. Heavy cloths and heavy boots. I farm and tend to have tool belts, tool vests, tool pails and fence posts, 20lb pounder, post puller, chainsaw and other things on hand while doing chores & walking fence lines. Never do gym workouts - designed it into my life. Six and a half days a week workouts. No body aches or pains other than my left wrist which I broke badly in my twenties (rock climbing) and that is only a twinge. A reminder not to try and push the entire planet away with one hand. I am balding - genetic male pattern baldness - but my hair is still 99% black no colorants. I am very active, eat a good diet with plenty of fatty meat (I raise livestock on pasture and garden), have minimal contact with people (most are stress puppies), dance (primary human contact and that is low stress), live out in the peaceful mountains and I probably have the benefit of good genetics - long lived healthy well educated ancestors who had lots of kids. I hear people talk about all the problems of aging but it isn’t something I am experiencing. Are there large numbers of quietly well aging people? Are we mostly hearing from the squeaky wheels, those who are having trouble? I am quite interested in this topic and you covered it well. I think we are on the edge of longevity escape velocity as advances in computation, AI, physics, engineering, genetics, medicine and more all compound on each other. Interesting times. 8 currecp currecp 1 month ago Please do more antiaging videos 1 sid mcgoo sid mcgoo 2 weeks ago loved it, doing stem cells in Mexico 3 Sciencerely J P J P 10 days ago Valine has been ignored for far too long. Valine needs to be researched more. 1 Ted Allison Ted Allison 10 days ago Aging is also a mindset ingrained from birth. We're " supposed " to get old & die.Right? BUT...... do we really have to? A Harvard professor has a book on the NY Times best-selling list that says" attitudes about age can contribute to plus or minus 7 years of lifespan. " Exactly---our minds have an overarching control mechanism which, while difficult to locate & or describe, does however exist. We set into motion a whole cornucopia of manifestations that strongly contribute to & parlay into a foregone conclusion of how we live. Health is predominantly a choice. I contend that aging & dying is too.....@ least to a degree.I'm def NOT sold that dying is a necessity----too ineffective inefficient & downright stupidly wasteful, correct? Patience will prove over time that once we activate a much higher percentage of our brains functioning we will arrive @ a more attractive future. MSTAMRO MSTAMRO 11 days ago (edited) Great video. Thanks a lot. Shelly Gardner Shelly Gardner 2 weeks ago The last thing they came up with kinda did the exact opposite of this, so it's difficult to believe they are really working on this for us Plebs 1