The Link Between Proteins, Alzheimer’s and Parkinson’s Diseases

The Link Between Proteins, Alzheimer’s and Parkinson’s Diseases University of California Television (UCTV) 1.35M subscribers Subscribe 1.2K Share Download Clip Save 70,979 views Oct 18, 2024 Proteins are large biomolecules that play critical roles in a host of cellular processes, from cell signaling to regulating the immune system. However, these life-giving proteins can form toxic aggregate species that have been linked to several neurodegenerative diseases, including Alzheimer’s Disease and Parkinson’s Disease. In this program, UC Santa Barbara professor Joan-Emma Shea discusses the tau protein as a model system to study neurodegeneration. Shea says this protein plays a functional role in stabilizing microtubules in brain cells, but it can also self-assemble to form amyloid fibrils (large “clumps” of Tau proteins). There are several neurodegenerative diseases linked to tau assembly, including Alzheimer’s Disease, Pick’s Disease, and chronic traumatic encephalopathy, and they are collectively known as tauopathies. Shea discusses new insights into tauopathies and targets for therapeutics. Recorded on 06/26/2024. [10/2024] [Show ID: 40083] Donate to UCTV to support informative & inspiring programming: https://www.uctv.tv/donate More videos from: GRIT Talks (https://www.uctv.tv/grit ) Explore More Science & Technology on UCTV (https://www.uctv.tv/science ) Science and technology continue to change our lives. University of California scientists are tackling the important questions like climate change, evolution, oceanography, neuroscience and the potential of stem cells. UCTV is the broadcast and online media platform of the University of California, featuring programming from its ten campuses, three national labs and affiliated research institutions. UCTV explores a broad spectrum of subjects for a general audience, including science, health and medicine, public affairs, humanities, arts and music, business, education, and agriculture. Launched in January 2000, UCTV embraces the core missions of the University of California -- teaching, research, and public service – by providing quality, in-depth television far beyond the campus borders to inquisitive viewers around the world. (https://www.uctv.tv ) Transcript Follow along using the transcript. Show transcript University of California Television (UCTV) 1.35M subscribers Videos About Facebook 99 Comments rongmaw lin Add a comment... Pinned by University of California Television (UCTV) @uctv 1 month ago Check Out: "Mind-Body Medicine to Build Stress Resilience" here: https://youtu.be/OIRT2gFPHOE 6 Reply 1 reply @monnoo8221 1 month ago (edited) wrong title: it is not about "proteins", it is about the tau-protein, which gets dubbed as a "cause". ...while it is just a stepping stone in a causal chain 37 Reply 3 replies @lseh4720 1 month ago These computer models are amazing. I always wonder what kids would say if they saw these interesting scientific images. Thanks so much. 8 Reply @Diagnoc 1 month ago Super interesting. I can’t wait to read more on the subject. 6 Reply @padasher5020 1 month ago very informative subject. Thank you...please continue your great work 7 Reply @marishkagrayson 3 weeks ago Very interesting. Thank you. My first thought when I heard “seed” was that indeed the protein fibers seem prionic. My second thought was that inflammation plays a big role which means the immune system is very much involved in various dementia. It would not surprise me if later research was to reveal that individuals with early onstage dementia in addition to the substitution mutation of proline to lucine also have disrupted immunological response to infection/damage. If you recall in use of ChAdOx1 as an adjuvant, it elicited an immunological response, forming clumps in a small subset of individuals. Since your computer simulations showed that at higher temperatures more space was created for misfolded strains, please pursue the possibility that brain inflammation following repeated infections over a lifetime may lead to the fibril/misfolded plaques and disrupt the hairpin formation. 5 Reply 1 reply @johngrundowski3632 3 days ago Great program ; So good to hear♒️📚⚕️ Reply @bartvanransbeeck1341 1 month ago What if body starts making tau and abeta proteines to protect brain against inflamation caused by junkfoods, microbiome disbiose, glycation by refined sugars ... 8 Reply 2 replies @xox0xx 1 month ago BREATHING IS RELATED TO ALZHEIMERS AND PARKINSON'S IN CERTAIN CASES.. 11 Reply @mfander123 3 weeks ago It's like you found a burn down house, then found blackened wood frames, then runs billions of scenarios, to find out which scenarios would produce blackened wood! 3 Reply @michael-qp9xd 1 month ago Some research reporting lower intake of protein in diet is better overall for longevity especially when limiting in under 50 to 60 yrs of age. But after 60 research indicating better to increase protein amount. Maybe limiting protein in younger years then have less materials for creating on tau tangles? Also any thoughts on the protein ingested and how the protein was created (cooked etc.) prior to ingesting? Please could comment? 5 Reply 1 reply @trytorememberallthis 1 month ago The key is to eat plant-based protein. More and more research nowadays show that plant-based diet can be protective from Alzheimer's. Good gut microbiome promotes proline synthesis in our bodies. Studies found that vegans as a whole have the best gut bacteria. Legume, nuts, mushrooms and many other plants are good dietary sources of proline. 11 Reply 5 replies @felicisimomalinao1981 1 month ago Awesome lecture. Proline is protective agent; however, leucine take away this protection. Even if leucine is good for muscle synthesis, it is bad for overall health. Proteins are re-cycled if not much protein is eaten. Mutation or formation of Tau Proteins cannot occur in low protein diets and sufficiently intense exercise. High protein is bad according to Dr. Campbell, Dr. Dan Zatarski, Dr. Longo, Dr. Rosdale, Dr. Tim Spector and others) 8 Reply 3 replies @humblerojo6300 1 month ago So intriguing. Apparently Proline is key. Although Proline is a non-essential amino acid, meaning the body can make it, perhaps that process is energetically expensive or perhaps becomes broken in people who starve themselves of dietary proline forcing the body to rob and convert other amino acids to make it. Therefore, wouldn’t consuming enough bioavailable proline be the most likely solution? A dietary chronology comes to mind here. We were diabolically told to stop eating red meat, cholesterol (eggs) and saturated animal fats which led to the influx of seed oils and animal replacement proteins. People started starving themselves of the best sources of proline, collagen and essential cholesterol like meat, chicken skin, eggs and bone broth which includes all of those proline rich, knuckles, joints, ligaments and tendons that humans once prized in their recipes. There is a small amount of proline in some vegetable matter but meat, dairy and eggs are truly rich in the amino acids that are also in the biologically similar ratios to humans and in an easily digestible and bioavailable forms. On the other hand, I would think that forcing the body to convert plant based amino acids that are in ratios not similar to human biology might create eventual proline conversion inefficiencies and deficiencies. 2 Reply @truthboomertruthbomber5125 3 weeks ago What about aluminum? 3 Reply 1 reply @RobertKelly-x2y 1 month ago Too bad that the negative effects of free radicals on proline protein as an anti-oxidant was not mentioned. 1 Reply 1 reply @hobbyfarmer1452 1 month ago As a non-medically educated person, my takeaway is )1 not to let Taus fly out of its original positions; 2) limit leucine intakes and increase proline intakes. Am I missing a point? 4 Reply 5 replies @hongchen9566 1 month ago How about dairy product? 1 Reply @lesfaby8997 1 month ago 24:28 extra Prolines are added to the Spike mRNA encodings in the covid vaccine so it does not change shape, as well. 2 Reply @galaxymetta5974 1 month ago Leucine is abundant in animal protein. 2 Reply 1 reply @michael-qp9xd 1 month ago Hello - great work. Have read brain cells not really dividing much - so if cell gets tau tangles and not to divide then no new daughter cells created with this tangle issue. But many not fully true on brain cells not dividing and these cells do divide so new brain cells like have with many other cell types? Reply @pavelsmith2267 1 month ago Metabolic proteins to empower the study of A.I. Parkinsons is where the neural systems become embedded in traits of neural resting disintegration. Too much of not enough mental activity and Parkinsons is yours to battle. Reply @krishnaveganathar 1 month ago See the 2024 study headed by Dr. Dean Ornish. Plant based eating is both preventative and healing. 6 Reply @bartvanransbeeck1341 1 month ago The persons i knew with neurodegeneration abused alcohol ,sugar , softdrunks, adiction 5 Reply 1 reply @SladkaPritomnost 1 month ago (edited) APOE4 carriers are prone to HSV-1 outbreaks cause their APOE contains more arginine which HSV-1 metabolize. Plant based proteins (usually contain more arginine than lysine) make them more prone to HSV-1 outbreaks, just saying. 1 Reply 1 reply @michaelhall2138 1 month ago Seems a song to the joy of research. Cure? Theories? 2 Reply @Mazeisaspace 1 month ago Tau is not causal in regards to Alzheimer 4 Reply 5 replies @ggvideonow1 1 month ago (edited) Very interesting. Presented excellently for all to follow along. It was cool to see Newton’s F=ma in this cutting edge simulation. I thought after high school, everything is using that head spinning thing called quantum. 3 Reply 1 reply @titussteenhuisen8864 1 month ago Someone working on a method to change the genetics? To get less leucine and more proline in our brain? That the genetic start of plaque forming is taken away. This is not a cure for all dementia but it will help many. Looking forward to this genetic manipulation. 1 Reply @zack_120 3 weeks ago 22:40 - ??? Reply @owenpope353 1 month ago Looks like anaesthetic poisoning to me. 1 Reply @helenhunter4540 1 month ago So vegans and vegetarians don't get mad cow disease. 1 Reply 2 replies @michaelhall2138 1 month ago Seems a song to the joy of research. Cure? Theories? 1 Reply