The Proof with Simon Hill 272: Is Longevity Science Overhyped? | Professor Charles Brenner | The Proof Podcast EP #272

Is Longevity Science Overhyped? | Professor Charles Brenner | The Proof Podcast EP #272 The Proof with Simon Hill 37.4K subscribers Is Longevity Science Overhyped? | Professor Charles Brenner | The Proof Podcast EP #272 The Proof with Simon Hill 37.4K subscribers Subscribe 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 Share Download Clip Save 23,960 views Jul 31, 2023 The Proof with Simon Hill The desire to live longer is not new to humans. But as time goes on, the concept of extending lifespan seems to be less about fantasy and more about a scientific “cure”. In our rush to find a silver bullet, has science been subverted along the way? 👇 Visit The Proof website for the full show notes and supporting studies. 👇 https://theproof.com/podcast/ In Episode #272, Professor Charles Brenner joins me to answer this very question. There is immense opportunity for profit in the longevity and lifespan space, and therefore ample opportunity for misleading health claims and second-tier science. Dr Brenner brings his professional stance to the table in this conversation, offering his take on recent scientific developments and the big players in the aging conversation. Specifically, we cover: - 00:00 - Intro - 03:54 - Do we have the genes to live beyond 120 years? - 14:18 - The genetics of extreme longevity - 18:26 - Longevity in the animal kingdom - 31:22 - Why do we age, and the realities of extending lifespan - 39:01 - How long can we live? - 43:49 - NAD coenzymes and DNA repair - 55:17 - "Anti-ageing" products - 1:01:08 - Conflicts of interest and the integrity of scientific claims - 1:03:19 - Discovering nicotinamide riboside (NR) (vitamin B3) - 1:10:22 - Sirtuins as anti-ageing genes - 1:20:05 - A rebuttal to Drs. David Sinclair and Lenny Guarente - 1:33:28 - Seeking consensus on the study of human longevity - 1:44:13 - The information theory of aging - 2:04:25 - Dr. Charles Brenner's theory of ageing - 2:05:30 - How to age better - 2:07:25 - Dr. Brenner on the quality of life - 2:11:05 - NR supplementation - 2:17:46 - Moving beyond Yamanaka factors - 2:19:40 - Outro Connect with Dr Charles Brenner: - Twitter: https://twitter.com/CharlesMBrenner - Website: https://www.brennerlab.net/ If you have any additional questions you would like answered in the future, let me know in the comments. Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test, and a significant discount at http://insidetracker.com/simon. The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. Enjoy, friends. 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Chapters View all Explore the podcast 82 episodes The Proof with Simon Hill The Proof with Simon Hill Podcasts The Proof with Simon Hill 37.4K subscribers Videos About 23K views 4 weeks ago The Proof with Simon Hill The desire to live longer is not new to humans. But as time goes on, the concept of extending lifespan seems to be less about fantasy and more about a scientific “cure”. In our rush to find a silver bullet, has science been subverted along the way? … 169 Comments rongmaw lin Add a comment... @marcusryder95 @marcusryder95 4 weeks ago It boggles my mind how this channel only currently has 30k subs. I love your content Simon. Keep it coming. Just settling in with this one now, looking forward to it. 57 Reply 13 replies @sleazycakes @sleazycakes 4 weeks ago Certified banger! A well-read interviewer makes all the difference and sets this channel apart from most others. Now do a 7 hour series on longevity 22 Reply 1 reply @clovergraham1067 @clovergraham1067 4 weeks ago I am 66 years old and I have been following David Sinclair protocol for the past four years. My life has been significantly better. Everyone thinks I am in my forties. He is a trailblazer for mankind. 24 Reply 4 replies @zhilahaghbin4766 @zhilahaghbin4766 4 weeks ago Simon, I am more impressed with you doing the research and pushing back and asking the definition of terms most people are not familiar with, because if all Lay people can follow your channel more would; Also admire how respectful you are and avoid taking sides , though it hard when dealing with such giants Dr. Brenner and Dr. David Sinclair. I have a great deal of respect for you, because I sense you treat this interview as if Dr. Sinclair was there and you present some of his rebuttals, which is very impressive. Like NMN doesn't directly get into the cell but it goes via NR. Stay ego free as you are, so "beautiful". 21 Reply @KirkVidrine @KirkVidrine 4 weeks ago Simon, I think the overall concept Dr. Brenner is making that longevity research in yeast or animal models doesn’t necessarily translate to human longevity comes through. But it would be appreciated if you could summarize his ideas in a future short. At some points his concepts were hard to follow. Appreciate all the great work you and your team does. 8 Reply @k.h.6991 @k.h.6991 4 weeks ago Charles Brenner is full if interesting facts, studies and perspectives. More on how long lived human women are would be great. Women feel a bit left out in society after 50, but it appears there are essential biological reasons for us to live this long. Loved that. 14 Reply 1 reply @olyav5819 @olyav5819 4 weeks ago Great interview! Hope you can get David Sinclair and Charles Brenner on the same podcast for a good debate :) 15 Reply 1 reply @adamd9418 @adamd9418 4 weeks ago What an amazing interview Simon! Talk about an in depth, informative, and nuanced conversation! 3 Reply @carinaekstrom1437 @carinaekstrom1437 4 weeks ago This was extremely interesting to me. He made a lot of things make so much sense about longevity. Really made me think. 5 Reply @ultmiddle4991 @ultmiddle4991 4 weeks ago (edited) Believe me, as a grandmother I felt as though I had enough wisdom and resourcefulness to begin parenting! Up until then it was all exploration, trial and error 😅 3 Reply @susymay7831 @susymay7831 4 weeks ago Thank you for your wonderful timestamps!!! They are a big plus ❤❤❤ 6 Reply The Proof with Simon Hill · 1 reply @markgarcia5845 @markgarcia5845 3 weeks ago I watched all of David Sinclair's 7 part podcast series that he had a few years ago, and I've seen him on several long yt interviews. I liked him and thought he was saying interesting things. But I couldn't help but feel he said some contradictory things. I'm not trained in the sciences, so I chocked it up to my not knowing enough. But I did notice that sometimes the host would say, you don't dye your hair and you have not gray, and he would let the comment stand, or he himself would intimate the same on other yt podcasts. But then I would notice that his hair color would change. And once he finally said that he was dying his hair out of boredom in covid lock down. I always just had a big question mark with him. Prof Brenner seems very credible and very logical with healthy scientific skepticism. @The Proof with Simon Hill thank you for having him on and having this amazing, clarifying conversation. Very helpful. I would be surprised if Sinclair would agree to have a conversation with him. But that would be interesting. 9 Reply @BrunoSpellanzon @BrunoSpellanzon 2 weeks ago again, amazing work Simon! both of you! thank you 1 Reply The Proof with Simon Hill · 1 reply @zachcain2639 @zachcain2639 3 weeks ago Great discussion! Would love to see the discussion between him and Sinclair. And I know you’d be a fantastic and fair moderator 1 The Proof with Simon Hill Reply The Proof with Simon Hill · 1 reply @michaelzephyr6447 @michaelzephyr6447 7 days ago Outstanding content. I loved it! Reply @Joy80JJ @Joy80JJ 4 weeks ago Great discussion listened while cycling. Would love an interview wirh Sinclair and Brenner. I learn so much from your channel. 5 Reply 2 replies @JustJamey @JustJamey 4 weeks ago I hope that David Sinclair does join them for a discussion. It may be better than Tate vs Carbstrong! 2 The Proof with Simon Hill Reply @chleoi4160 @chleoi4160 4 weeks ago I am so glad you brought this wonderful expert to respond to some of David Sinclair's claims, I never liked how David states his claims as facts & doesn't really cover the science details behind them! 1 Reply @anastasiailieva7800 @anastasiailieva7800 4 weeks ago It's worth watching and re-watching many times, so interesting... Yet can sb pls explain why we hope to manipulate information (DNA in this case) through such basic methods as surgery ( inserting a nucleus in a new cell, removing genes) or chemistry (supplementation) instead of trying to work on a physics level as even ATP production is a matter of moving electrons and protons, after all. Isn't M.Levin actually working on sth like that, electrical blueprints directing the functions of the body? Also, how come we applaud the fact that primitive creatures like gut bacteria should send signals to our immune cells and to our brain and control them instead of things being the other way round? How come our brains cannot control our own cells and their DNA? Why is this considered unsuitable for scientific research, mumbo-jumbo etc., and not the most logical thing in the world? 1 Reply @mersingjohor2826 @mersingjohor2826 3 weeks ago (edited) 'People used to live to 40 and now we live longer'. That statement maybe true in your part of the world but certainly not true in mine. I remember playing in my great grandparents house when I was a child. Before they moved to Thailand to clear a jungle for rubber plantation. They both passed away when I was in my thirties. My grandmother, their daughter, died just over a hundred. Also when I was in my thirties. They were not exceptions. People in my part of the world used to live that long. I'm 59. By today large portion of my school friends already passed away. Since we went to prestigeous premier school, most of them died in expensive private hospitals. Ask anybody in this part of the world, who was from and born in rural areas, they'll tell you the same story. 5 Reply 1 reply @454student @454student 4 weeks ago Hey Simon! Big fan of your show / podcast. I'm from Sydney Australia too! Would you ever sell any t shirts / merch? I would love to support you and your brand. Please keep doing what you're doing! 1 The Proof with Simon Hill Reply The Proof with Simon Hill · 1 reply @CristianWorthington @CristianWorthington 13 days ago His position on rapamycin doesn't consider a dosing regiment in which the drug is taken intermittently. But I think he may be correct in the over arching position that drugs like rapamycin may only impact health and longevity within the scope of a maximum age (e.g. 120). At this stage, we're still working within the confines of our genetic destiny. Perhaps in future we'll be able to alter genetics or epigenetics in a living person. Hopefully this will happen in my lifetime. Reply @fatboydim.7037 @fatboydim.7037 4 weeks ago He explains his own theories incredibly well but it still doesn't explain why people who follow the Sincliar protocols look, feel and move like they are younger and why DNA test show this. 3 Reply 1 reply @justicericketts2912 @justicericketts2912 4 weeks ago Great video! Recommend this podcast to everyone! 1 Reply @semaaral2498 @semaaral2498 2 weeks ago Can’t be happier to see our Handsome Prof Charles Brenner talking with Simon👏 on a sofa, relaxed & confident🕺💊🧬💊🧬 This cool look, made him look more handsome🕺 Don't know his age but looks similar to my son's age cause they are both bold😊& handsome. So happy to see our valuable Prof Brenner also talking about cool for our valuable PHD Dr David Sinclair 🕺💊🧬💊🧬 Love you both what a big gift are you both for Science on this Planet Earth. I feel so privileged to know you both. I'll never forget that you replied to me couple of times from tweeter😅 when I was in need🙏😔 God Bless you all Scientists and People who are working for humanity🙏🙏 A grandma👵 from London☔️ 1 Reply @DrSamsHealth @DrSamsHealth 3 weeks ago Great interview. I wish Dr.Brenner was as eloquent as people who hype things up. Reply @rsalehi6568 @rsalehi6568 2 weeks ago To think that a lab can come up with a single molecule or multiple molecules to reprogram an organism as complex as a human, for longer life or even health, at this early stage of our advancement is wishful thinking. Reply @gerardklauner902 @gerardklauner902 4 weeks ago I have read that female whales live well beyond their fertility, and it can be explained by their grandmother role, like in humans, 3 The Proof with Simon Hill Reply @Pixel-junkiesOrg @Pixel-junkiesOrg 4 weeks ago Interesting to hear about Rapamycin. Its another one that made me nervous due to well what it does hehe. Reply @jemima4567 @jemima4567 4 weeks ago One of the best ever. Thank you Reply @landerhendrickx3522 @landerhendrickx3522 3 weeks ago "This is how you clone an animal." I really hope very few people will try 😅 1 Reply @peterz53 @peterz53 4 weeks ago (edited) PS @46m on the issue of NR supporting the NAD+ system which helps with DNA repair, it has been shown that exercise in older people maintains NAD+ to more youthful levels, suggesting that people who exercise regularly and to sufficient levels can also improve repair mechanism (Ref. R Houtkooper 2021 presentation at ARDD via Youtube, and "Healthy aging and muscle function are positively associated with NAD+ abundance in humans" Janssens et al 2022 in Nature Aging). 4 Reply 1 reply @doghashisday4612 @doghashisday4612 4 weeks ago David Sin never met a study he couldn t find to market it 😂 7 Reply @advertiserfriendlyusername5362 @advertiserfriendlyusername5362 4 weeks ago Professor Charles Brenner once gave an interview to Dave Asprey. He has since dedicated his life to burning anything and everything to do with longevity or health span to the ground. 8 Reply 3 replies @sandradings8660 @sandradings8660 4 weeks ago Very exciting topic ! Reply @culchie1982 @culchie1982 3 weeks ago In a word yes. Genetics are absolutely paramount and the massive role they play is often downplayed by the so called experts like Sinclair, Attia etc. There are way, way too many “anomalies” out there who do all the wrong things and live long lives. And by the same token, there are way too many people who do all the right things eg diet, exercise etc and go out like a light at 60. Reply @tatiananikolskaya6991 @tatiananikolskaya6991 2 weeks ago (edited) Dr. Brenner is 62 and he looks his age. He isn’t crazy about anti- aging, as we just learned. Dr. Sinclair is 54 and he looks way younger and we all know what he does to stay young. Isn’t it ironic? And then there is Bryan Johnson, 45, who looks like 35 and who sacrificed most human pleasures to reverse his age and achieve excellent health. Time will tell, of course, but mirrors don’t lie… Reply 1 reply @samieramohamed2467 @samieramohamed2467 3 weeks ago I agree with this professor statement about stories and repetition of same attractive topic to fool lay people. 2 Reply @espinosalexis @espinosalexis 3 weeks ago (edited) Did you notice that Brenner avoid to talk about Niacin? And about SIRT6 activators (V. Gorbunova research)? Good scientific results in those two compounds seem to be legit, and a bit against his own narrative/benefits. I guess he is not completely clean and still has some work to do on himself to be fully transparent. Anyways, I really appreciate his critics of the bad science in anti-aging research. (Please pass this message to Brenner too) 3 Reply @peterz53 @peterz53 4 weeks ago (edited) Great discussion. From listening to quite a number lectures by aging researchers it seems that the damage/repair hypothesis keeps coming up, and central that is DNA repair. Vera Gorbunova who looks at long lived animals has shown that longevity seems to be correlated with ability to repair double strand breaks (or prevent them) this is apparently a key mechanism by which the bowhead whale can live to over 200 years. 1 Reply 1 reply @williamhenry3337 @williamhenry3337 3 weeks ago My father-in-law was always a chubby guy that NEVER excercised a day in his life. He did not eat large amounts of junk food. He did eat macaroni and cheese and the regular American diet. He passed away last year 6 months before his 100th birthday. Some people just live longer. Reply 5 replies @StephenMarkTurner @StephenMarkTurner 4 weeks ago Way above my head, but still interesting to listen to. Last night I started to re-watch a fun Canadian sci-fi horror film called 'Splice', seems quite appropriate :-) 1 Reply 1 reply @kellyabrahamson9139 @kellyabrahamson9139 4 weeks ago Leucine & adequate protein pulsing, I hope I’m on the right track to aging well 2 Reply @weiminyang7206 @weiminyang7206 3 weeks ago Dr. Brenner has many good points, I learned that circular ribosomal DNA is an important factor that contributes to the yeast life span of the mother cell. However, he is a little off-topic. The term longevity or lifespan is applied to individuals, not population. When I separate the yeast daughter cell from her mother, I focus on the mother cell- i.e.an individual cell, not the whole flask of yeast cells. 1 Reply @SquatFull @SquatFull 4 weeks ago Will nicotinamide riboside (NR) enhance NAD+ levels in the mitochondria matrix? If so, will the NAD+ be used for the citric acid cycle to transfer electrons to the electron transport chain? I am not a fan of the anti-aging scientists. The question regards aging more healthy since ATP production is essential. I am 74 years old and using resistance weight training to minimize the impact of sarcopenia. 1 Reply 1 reply @newdata @newdata 4 weeks ago (edited) can see that david sinclair health advise is good as his biomarkers look like not going downhill fast Reply @douglas.abramski @douglas.abramski 4 weeks ago So longevity and fertility are like a ⚖️. When one goes up, the other goes down. So the game is see-saw. Reply @sebacatana @sebacatana 4 weeks ago Spoiler alert: YES 18 Reply @samieramohamed2467 @samieramohamed2467 3 weeks ago In Yeast, NR .NAD Co enzymes essential for repair capacity. DNA damage and inflammation target repair mechanisms.Insults like Covid attack repair mechanisms like DNA repair, lipid formation,NAD decrease in kidney diseases, heart failure 50:31 NMN is NR with phosphate which must be removed before used as NR ,3 kinds of B3, Reply @waslick11 @waslick11 4 weeks ago I'd rather listen to Doc Brenner and Simon talk about NAD than watch the Grand Finale of Yellowstone...😂😉...Kevin Costner better Watch Out....😂 The Proof with Simon Hill Reply @kurthanson7522 @kurthanson7522 3 weeks ago Highly amusing having Charles Brenner dropping longevity truth bombs only for your show sponsor to be Inside Tracker (David Sinclair) 🤣 1 The Proof with Simon Hill Reply The Proof with Simon Hill · 1 reply @carinaekstrom1437 @carinaekstrom1437 4 weeks ago Some religions try to keep males and females apart at younger ages. Not very successfully though. And so far I don't think they live longer, but maybe if they stick to it for hundreds of generations, and keep mating later and later. I wonder which is the society or tribe that has the latest mating ages. Most have probably been in a hurry to mate in order to have any survival advantage at all. It seems that in societies where survival becomes easier we naturally tend to have offspring later in life. 1 Reply @mikeallen5865 @mikeallen5865 3 weeks ago The Social Security Inspector General Report says that 6.5 million people are 112 years old. I would say it is overhyped! Reply @samieramohamed2467 @samieramohamed2467 3 weeks ago NR improved blood flow, moderate rise of hypertension, improving body composition.Work out recovery faster and better.NAD in mitochondria diseases.NAD metabolic test. Reply @fionadale8044 @fionadale8044 4 weeks ago I wonder what Dr. Brenner thinks of Inside Tracker? 2 Reply @pjaworek6793 @pjaworek6793 4 weeks ago (edited) Can it make YOU live longer? If so, it's anti-aging. Exercise and healthy lifestyles are anti-aging. Any problem with this language by Brenner and others is highly suspicious. Whatever you want to call living past 120 years, it's definitely going to happen. How could anyone deny that we'll live longer than humans before the information age, before computers and modern diagnostics. I could go on and on about how things have changed since we reached 120 year lifespans. 1 Reply @LTPottenger @LTPottenger 2 weeks ago We already have the genes to live a very long time, but our repair mechanisms are only fully engaged while fasting. Reply @rapamune @rapamune 3 weeks ago Fantastoc episode Reply @sandywatson9115 @sandywatson9115 3 weeks ago Pushing his products, no different than Sinclair. 4 Reply @samieramohamed2467 @samieramohamed2467 3 weeks ago 300 mgs In stress like Covid 1 gram is the dose. Reply @evanrosenlieb8819 @evanrosenlieb8819 4 weeks ago There's great discussion here of NMN/Sirtuins, but I think he isn't super up to date on rapamycin/MTOR1. Its true that MTOR is generally speaking a regulator of skeletal muscle maintenance but even the experimental evidence we have already shows that the effects are anything but straightforward. Reply @gerardklauner902 @gerardklauner902 4 weeks ago A way to prolong longevity in humans would be to force women to freeze their embryos. Those embryos would be implanted on young women, only if the actual genitors lived a long life, without serious illnesses. Women would only be allowed to carry their great grandmother's babies, on that condition. As frightening as 1984 ! 1 Reply 1 reply @marcusryder95 @marcusryder95 4 weeks ago Big trouble in little china. I need to see him debate Sinclair, fight fight fight😂 2 Reply 1 reply @samieramohamed2467 @samieramohamed2467 3 weeks ago Growth hormone receptors,synthesis of NAD pathways,Found NR is pathway to NAD.Metabolism is bio oxidative catabolism energy, built structure, anabolic and repair, Reply @fredrikgustafsson7812 @fredrikgustafsson7812 2 weeks ago Did they discuss rapamycin? I listened but might have missed it? Reply @meandme8049 @meandme8049 3 weeks ago 1. David Sinclair is a different league. Why would he debate that guy. He doesn’t need to prove himself. 2. Go ahead and explain to the people who follow DS recommendations that longevity theory doesn’t work. They see that this theory works by looking in the mirror everyday. Reply @pjaworek6793 @pjaworek6793 4 weeks ago (edited) Although i relish in this topic and want to hear any and all opinions and discoveries, I have a lot of gripe with Brenner here. "Longevity genes". No one is talking much about these but rather epi-genes, eg sirt6 and other examples of genes are needed for longevity. Is this just semantics like saying food/water is a longevity factor? Another gripe in general, I've been focusing on sleep quality to do two things in particular, increase glutathione and increase growth hormone. Now Brenner makes a fervent point that GH will shorten our lifespan while making us healthier. There's debate out there on this point and i dont think its settled. Here's a more balanced quote from the web with this nuance: "However, there is also evidence indicating that higher growth hormone levels decrease longevity. In some cases, higher growth hormone levels may increase the risk of certain diseases and may cause some conditions, such as cancer, to accelerate.Jun 15, 2022 Reply @laurensargent9471 @laurensargent9471 4 weeks ago If we don’t address the climate crisis right now, only those who are already 100 are going to live to 120 Reply @jobyyboj @jobyyboj 3 weeks ago The growth hormone treatments mentioned are transient, and not through the remaining lifetime, if he is referring to TrimX+. They are intended to regrow the thymus, and prolong immune system function. This remains to be confirmed through larger clinical trials, but has shown signal in the original small cohort on nine, and pending results from a larger one. It is misleading to imply that the treatments are intended over the course of the remaining lifetime, which would probably shorten longevity as asserted. There was also persistent epigenetic rejuvenation from the transient growth hormone treatment, albeit for the small cohort. Those results are also pending being confirmed with a larger cohort, which is in process. Reply @kunverjihirani276 @kunverjihirani276 4 weeks ago 👍😊🙏 1 Reply @catman4471 @catman4471 4 weeks ago There are so many medical scientists who have different opinions on NAD pre-cursors and longevity supplements, and although I can see how knowledgeable Brenner is, what he say's does not fit with the results I get. Reply 2 replies @samieramohamed2467 @samieramohamed2467 3 weeks ago A lot of stories telling to market products and get more money. But the truth will prevail.Sun will shine. 2 Reply @Icarianbrother @Icarianbrother 4 weeks ago Is regularly visiting brothels the next longevity hack? 2 Reply The Proof with Simon Hill · 3 replies @orhanyuce2864 @orhanyuce2864 2 weeks ago He didn’t say no sugar , blood sugar level Reply @fredrik7922 @fredrik7922 4 weeks ago Dr Brenner did not discover NR though, as he claim. He discovered the NRK1 and NRK2 enzymes. Reply 1 reply @aaronplata9152 @aaronplata9152 4 days ago Pro tip --> play at 1.25x speed Reply @TheIgnacio777 @TheIgnacio777 3 weeks ago He really does no like Sinclair😮 Hyperbole meet parabola! 2 Reply @BakamonNO @BakamonNO 4 weeks ago Brenner is such a naysayer. 🤣 Reply @samieramohamed2467 @samieramohamed2467 4 weeks ago Molecular biology of aging is polygenic.Monogenic mutant exist related to growth hormone. Reply @samieramohamed2467 @samieramohamed2467 3 weeks ago Cream 2 percentage NR on skin used in Korea to improve skin elasticity in8 weeks . Reply 1 reply @landerhendrickx3522 @landerhendrickx3522 3 weeks ago Peanuts contain resveratrol, thank me later :) Reply @orhanyuce2864 @orhanyuce2864 2 weeks ago Do easy things kind of guy Reply @brianmccammon51 @brianmccammon51 3 weeks ago Sinclair has been become a shill for the money. 1 Reply @musicmonsterman8395 @musicmonsterman8395 4 weeks ago I always had a feeling Sinclair was a fraud. Lol 8 Reply 1 reply @jimparker3376 @jimparker3376 2 weeks ago I love alternative ideas but I don’t like wasting time w personal vendettas. Let’s talk science and leave the rest to twitter B Reply @dannnyjos @dannnyjos 2 weeks ago So, I guess Fasting is bad for you ? Reply @Jessica-kk1cz @Jessica-kk1cz 2 weeks ago Professor of what? Professor from where? What studies has he done? Put in the description. Sorry, I’m going with the Nobel Laureates. Reply @omrit2 @omrit2 4 weeks ago Sinclair always seemed to me self promoting and dishonest. 6 Reply 1 reply @angeladavies @angeladavies 4 weeks ago Exercise nutrition sleep water coffee maybe don't eat late, fast over night. Mental social stimulation, hygiene, immunisation, dont be over fed, goldilocks body weight & muscle mass. Don't eat unless hungry. Breathe, joy, purpose......I got to the end, avoidable stresses eg uv+, alcohol. Explore NAD NR, Use it or Lose It. Thankyou felt a honest educational conversation. At least I know their are some basic leavers I can do. 3 Reply @ilyam7671 @ilyam7671 3 weeks ago Longevity science is massively underhyped. Reply @ishandutta2007 @ishandutta2007 6 days ago This guy spends more time bad mouthing longevity researchers than talking about his own works on diabetes. Reply @samieramohamed2467 @samieramohamed2467 4 weeks ago Please professor go direct in the topic with out example of machine to start your talk.Too much about I , self, ego. Reply @KetogenicGuitars @KetogenicGuitars 4 weeks ago I started already to believe him but then he told all I have done 10 years is full of crap. He started to sound old school fossil like Ancel Keys to me. "You gotta enjoy your live(like I do and say) so you also are allowed to do all the wrong things". Even I lost 40kg(80lbs) and got my life back with low carb diet. I had to back a little bit. It might be because possibly he has never had to personally deal with such a serious metabolic and addiction problems in his life and at the same time he lacks empathy. I cannot blame him at all being himself but just make a note. I was really surprised. 1 Reply @Joseph1NJ @Joseph1NJ 4 weeks ago 360p? 1 Reply @catsanddoggettingalong2506 @catsanddoggettingalong2506 3 weeks ago This guy is such a bad communicator and has a bone to pick with David Sinclair. He's a horrible guest. He may be right but this interview is very hard to follow. 3 Reply @richiprosadmistry414 @richiprosadmistry414 4 weeks ago What a cheap way to get name recognition and make money! Reply 1 reply @ruinunes5448 @ruinunes5448 2 weeks ago huummmmmm he is a professor but i believe more in David S ..... Reply