Lifespan with Dr. David Sinclair Podcasts

460,770 views Jan 5, 2022 Podcast Episodes In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of "ex-differentiation" in which cells begin to lose their identity, and h ow all of this makes up the "Information Theory of Aging", and the difference between "biological age" and "chronological age" and how we can measure biological age through DNA methylation clocks. #Aging #DavidSinclair #Longevity Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Levels - https://levels.link/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsincla... Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclai... Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante Timestamps: 00:00:00 Introduction 00:03:14 Goal of the Lifespan Podcast 00:07:11 Acknowledgement of Sponsors 00:10:45 Aging is a Controllable Process that can be Slowed & Reversed 00:16:42 Organisms with Extreme Longevity 00:21:47 Genes that Regulate Aging: mTOR, AMPK, Sirtuins 00:21:55 mTOR & Rapamycin 00:24:33 AMP-activated protein kinase (AMPK) & Metformin 00:30:57 Sirtuin Proteins as Epigenetic Regulators of Aging 00:35:33 Ex-Differentiation 00:43:30 Measuring Aging - Biological Age vs. Chronological Age 00:49:30 "No Law That Says We Have To Age" 00:50:33 Episode Summary & Key Takeaways - Why Do We Age? 00:54:00 Information Theory of Aging 00:57:59 Aging is a Medical Condition 01:01:00 Aging Myths - Telomeres & Antioxidants 01:01:55 Options for Subscription and Support Links: Weapon fragments in bowhead whales - https://bit.ly/3eP7rqP Rapamycin extends lifespan in mice - https://go.nature.com/3F0yud3 Targeting Aging with Metformin (TAME) Trial - https://bit.ly/3eU9ABk Metformin improves healthspan and lifespan in mice - https://go.nature.com/3JSRZbs Metformin reduces all-cause mortality - https://bit.ly/3pWNiWc Reprogramming to restore vision - https://go.nature.com/335iysI DNA methylation age - https://bit.ly/3sUAUYB Genome-wide methylation profiles & human aging rates - https://bit.ly/3ETPXnK Reversal of epigenetic aging in humans - https://bit.ly/3eUior3 Danish twins study - https://bit.ly/3eToU13 Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. Chapters View all Explore the podcast 8 episodes Podcast Episodes David Sinclair Podcasts David Sinclair 299K subscribers Videos About 1,280 Comments rongmaw lin Add a comment... @Gadinata @Gadinata 1 year ago I have been following Dr. Sinclair since I was 33. I am 30 now. 1.7K Reply 52 replies @ChrisWillx @ChrisWillx 1 year ago Love this. Congrats mate! 107 Reply @RickyConnelley @RickyConnelley 1 year ago (edited) So glad he made a podcast! The fact we can listen “for free” to a Harvard professor teach is amazing! We live in cool times for self learning 16 Reply @BrentNally @BrentNally 1 year ago I’m stoked David finally has his own YouTube channel! Let’s all work together to solve aging ASAP! 221 Reply 12 replies @edison_ryan @edison_ryan 1 year ago I'm 15 and I'm so fascinated by the forefront research and discoveries in the field of longevity and I'm so glad you started this podcast! Thank you so much, can't wait for future episodes! 34 Reply 6 replies @jeffmiddlebrook5251 @jeffmiddlebrook5251 1 year ago Thank God for leaders like David who genuinely want to help mankind. My wife and I are 65 yo and we want life after 65 to be our active second life not a death sentence. We plan to share this information to whomever will listen and become disciples of longevity. 157 Reply 11 replies @zalareverie4745 @zalareverie4745 1 year ago I have been counting down and now this podcast is finally here! I am greatly inspired by you and Dr. Huberman and i'll be forever grateful to Lex Fridman to introducing you both to me. Keep changing the world for the better! <3 500 Reply 11 replies @odmineypiju4761 @odmineypiju4761 1 year ago I am 27 and in the last few years I began to notice, that some of my peers are aging much faster than me. This observation caused me to often contemplate the topic of aging, and when I listened to Dr. Sinclair on Huberman Lab, I subscribed to Lifespan right away. Thank you for your work and for making this information accessible! 37 Reply 6 replies @JumperAce @JumperAce 1 year ago The same way you feel more justified in taking fitness advice from some one who is visibly in shape, David is 50 and looks 30, and he's been applying his science to himself. Such an inspiring guy 15 Reply 2 replies @microwaveengineer6681 @microwaveengineer6681 1 year ago The combination of a scientist and a journalist for a podcast is just a match made in heaven. This is gonna be great! 25 Reply 1 reply @user-sb9ml1ef4q @user-sb9ml1ef4q 1 year ago "...we can control aging very precisely at will. We can speed it up as fast as we want in an animal, and even reverse it. So aging is now controllable." What a time to be alive. 19 Reply 4 replies @tonyamckimmy693 @tonyamckimmy693 1 year ago On my last leg of treatment for Lyme Disease. I sincerely thank you and Professor Huberman. Your teachings have given added strength to my hope that helps me carry forward. 27 Reply @billgarner1195 @billgarner1195 1 year ago David, I would like to personally thank you for your life‘s work and the work that you are doing in reversing biological aging. As one of your students applying the information gleaned from your research to my personal life and to the lives of the medical practices and companies we serve. All I can say is this is a hell of a lot of fun :-) 75 Reply @simonfoo8684 @simonfoo8684 1 year ago Excellent way to allow layman like me to understand better about the science behind aging. I have listened many of Dr. Sinclair's talks and interviews but this podcast is really well orchestra to enable viewer to better understand the subject matter. Thank you very very much to both of you. I really enjoy watching it and forget to eat my lunch, which is a good thing to miss! 11 Reply @Adam-nw1vy @Adam-nw1vy 1 year ago Dr. Sinclair is a hero. We owe him a debt of gratitude. I have been following him and his work since 2016 like every single week. I'm so glad that there is a podcast now! The only thing that I'm worried might derail this fantastic and groundbreaking research is the political turmoil in the US. We need to make sure that this research reaches fruition no matter what. 11 Reply @sneakers_guy5488 @sneakers_guy5488 1 year ago Thanks so much for starting this podcast series Dr. Sinclair! Matt's inclusion on this podcast is immediately evident to me to be a great decision, acting as an audience member (in a sense) asking the questions that many of us would in real time. Great format 👍 37 Reply @vidprofess @vidprofess 1 year ago Please do a season 2! Also, I would like to learn about doctors that are focused on lifespan approaches and therapies. 2 Reply @johnjudson8482 @johnjudson8482 1 year ago Thank you Dr. Sinclair and Mr. LaPlante for your book and now this podcast. When it comes to health, I feel like I have been stumbling around in the dark my whole life. The context and data that you have structured so beautiful is giving me hope that an actual and manageable path to health is within reach. You guys rock! 7 Reply 1 reply @wednesday6018 @wednesday6018 1 year ago I'm sure I speak for all of my fellow science lovers when I say, thank you for doing a podcast. It's so exciting! 😊 33 Reply 2 replies @vladimirivanov6015 @vladimirivanov6015 1 year ago Awesome first episode! Really looking forward to future episodes. This field definitely needs more popularization to change people's perspective on aging. 9 Reply @BetterHumans @BetterHumans 1 year ago So excited this is finally happening :0. I started your protocol 6 months ago aswell as a few other things and can't wait to start sharing my journey when I get the 2nd bloodtest from Inside Tracker...What I can tell you is I feel incredible....Lets get this train rolling! 6 Reply @jenniferdonnelly-montedeoc9285 @jenniferdonnelly-montedeoc9285 1 year ago I loved your book and recommended it to countless other healthcare professionals. Really exciting stuff! This podcast was excellent. I just can't say enough great things about you and your work. I'm so grateful that you are doing this podcast so that everyone can get as excited about these incredible advancements as I am! 15 Reply @georgeamine4275 @georgeamine4275 1 year ago This podcast is going to be a game changer for our species. 4 Reply @jamescarpenter2384 @jamescarpenter2384 1 year ago I would just like to thank you for your courageous efforts in keeping us all healthy and young if possible. I am sure that your grandmother is really proud of you now. I have been following you for several years now and find that Your explanation of your research is down to earth and clear especially for a nonscientist. I truly do hope that when you come out with formulas for the rest of us to take they will be available to all at an affordable price as you have said you would in past talks. NMN sounds very promising. Keep up the great work looking forward to all of your talks and podcast and once again I👏Applaud you 13 Reply @JeffNixonComedy @JeffNixonComedy 1 year ago This is going to be such a powerful podcast. Can’t wait! 134 Reply 1 reply @divyabhatia9916 @divyabhatia9916 1 year ago Thank you so much for starting such an amazing podcast and providing amazing information free of cost. You are an amazing researcher, human being and an inspiration. And thanks so much for amazing research you do and for teaching how we can use that information and implement it in our daily lives to make it better. 3 Reply @pareto3568 @pareto3568 1 year ago Read Lifespan and now listening to this. What a great opportunity to solidify the concepts expressed in the book and be up-to-date with new research. 3 Reply @danovic7822 @danovic7822 1 year ago Love this! Every bit of knowledge I can get about longevity I'll gladly take. Thank you David, for everyone you do for humanity! 13 Reply @luisrodrigueziii7316 @luisrodrigueziii7316 1 year ago I'm SOOOOOO happy that we finally have a David Sinclair podcast. Please keep this up, I look forward to the future of the show and the science that it'll teach. 3 Reply @teddy4097 @teddy4097 1 year ago I cannot wait to see what’s this podcast going to bring to the table! I learned about Dr. Sinclair on Whitney Cummings’ podcast and immediately after I read your book! Fast forward a few days and I decided to study Molecular Science in University to hopefully research aging one day! I cannot express my admiration for you enough! 35 Reply 2 replies @DrewMoon3000 @DrewMoon3000 1 year ago Congratulations on your official appreciated podcast. As an Aussie living abroad, you are a guiding light of inspiration. Thank you, Mate! 25 Reply @catsteinhilb2880 @catsteinhilb2880 1 year ago (edited) Thank you both for this … this is immensely valuable to all us humans striving to live longer, healthier lives ❤️ 1 Reply @MSHAMLETINBOSTON @MSHAMLETINBOSTON 1 year ago Thank you Dr. Sinclair. You came into my life via your work regarding the possible variants of Covid-19 in April of 2020. Omnicron was no where on the horizon. You provided forward thinking then and now. Tremendously excited about your program and looking forward to the next seven. I am sure that there will be another seven after that. Thank you again for your passion and dedication to science. 1 Reply @LongevityPlan @LongevityPlan 1 year ago We’re super jazzed David has his own YouTube channel and podcast now! The future is looking great! 72 Reply @MildaGoesWild @MildaGoesWild 1 year ago It's good to have a podcast coming directly from David as opposed to random interviews by others. 3 Reply @jenniferstrahan203 @jenniferstrahan203 1 year ago Absolutely amazing. This was more than I had hoped for, so much fantastic, mind blowing information. I cannot wait to be able to test my biological age affordably and often. I am very much looking forward to the subsequent episodes and the upcoming book! Thank you Dr. Sinclair for taking the time out of your very busy schedule to make this happen for all of us, this is truly a gift! 4 Reply @elenateplushkina4346 @elenateplushkina4346 1 year ago I'm very excited about this. I've just finished the episode from Huberman Lab podcast. You and Dr. Huberman briefly touched on the topic of fertility and age-reversing. I would be happy to learn more about it and the protocols women can benefit from to extend their fertility age. Thank you! 132 Reply 10 replies @volkerhiddemann7236 @volkerhiddemann7236 1 year ago Thank you Dr. Sinclair for this insanely insightful work that you provide. It’s a pure pleasure to listen. It makes me smile to whiteness the similarities between your and Dr. Huberman’s podcast, knowing of course that he helped to ramp this up. It’s great to have such powerful people see collaborate. Matthew La Plante brings a nice twist to the topic. Highly enjoyable. Looking forward to the following 7 episodes. 3 Reply @farhadkhan5224 @farhadkhan5224 1 year ago I’ve read Lifespan several times and been eagerly waiting for the latest updates from David Sinclair’s research. So glad to see this podcast. 3 Reply @Beluinduh123 @Beluinduh123 1 year ago Love the dynamic, having someone to bounce ideas and questions about this topic is important! Thank you both for this platform 🙏 18 Reply @fuscialilac3306 @fuscialilac3306 1 year ago Very pleased that you are going to share your knowledge and experience with us in the podcast format, Dr. Sinclair! I'm looking forward to learning more and working to optimize my biology and be creative and productive for years to come. Thank you! 1 Reply @Borromeo377 @Borromeo377 1 year ago Happy New Year David - a long awaited podcast 🙌🏼Thrilled to find out more in the subsequent episodes. Thank you 🙏🏼 10 Reply @SatbirAulakhMusic @SatbirAulakhMusic 1 year ago Thanks again David. Your book has changed my life and life of hundreds of my patients. I work as a GP in Darwin 18 Reply @tealaree @tealaree 1 year ago So glad to bump into your channel from huberman. You make a lot of sense and love the science behind it. I want to live long for my autistic son. I don't care about the cosmetic side of it although that's great. I want to do this so my son has a parent for as long as possible. Thank you for your research and endeavors. 2 Reply @larmikvonhorshley8631 @larmikvonhorshley8631 1 year ago I really appreciate Dr. Sinclair and the work h puts into making information so crucial to a long and healthy life available and accessible. The child in me can't help but see The crocodile hunter and The House of Pain guy having a casual conversation about epigenetics. We live in amazing times and are so fortunate that such dedicated people are willing to give so much of their valuable time to share their life's work with the world. I am both filled with gratitude and deeply humbled by this generosity, thank you both so much. 4 Reply @pauloconnor1857 @pauloconnor1857 1 year ago I've been so excited about this podcast....Here we go. Love your work David and thanks for bringing us this free information. 13 Reply @ak4good @ak4good 1 year ago So excited for this! After reading Lifespan wanted to keep following the developments and maybe add longevity molecule supplementation to my regimen of IF, exercise, sleep, breathing and cold exposure, but finding it hard to weed out the BS. Looking forward to the latest info from the leading researcher himself! :-D 1 Reply @lacrimossaa @lacrimossaa 1 year ago It's inspiring to see people in the scientific field working towards the wellbeing of people (spreding the word outside the field). Thank you for the wonderful work! It will have a huge impact on people :) Here to learn! Greetings from Monterrey, Mexico :) 4 Reply @redpilllense7125 @redpilllense7125 1 year ago (edited) This is AWESOME! Thank you, Dr. Sinclair, for doing the good that helps humanity. You are God sent! 19 Reply @zafrat5727 @zafrat5727 1 year ago What a time to be alive!!! My Goodness, I am so grateful to be learning this. Thank you Dr Sinclair and Matthew Laplante. Reply @sunshinemittens23 @sunshinemittens23 1 year ago Yeah!!! 🙌 So stoked you are doing a podcast!! Congrats & I’m thrilled to learn, learn & learn some more about health, longevity & more. Cheers! 🥂 1 Reply @asad9813 @asad9813 1 year ago This is such an amazing thing David has done to fans. It's going to be great! 3 Reply @denmar355 @denmar355 1 year ago Such great information! I’ve followed Dr. Sinclair for about three years, and he has a unique ability to explain deeply complicated concepts in ways I can understand. Great stuff! How to be a happy and capable 80-90 year old is quite a valuable recipe! Reply @lotfibouhedjeur @lotfibouhedjeur 1 year ago I'm bursting at the seams with excitement! Dr. Sinclair has an official YouTube channel. I love how assertive he sounds talking about what he knows. 6 Reply @ggbrait9406 @ggbrait9406 1 year ago THANK YOU!!! This is awesome! Grateful to my favourite members of the humankind, Lex and Andrew, for introducing Dr. Sinclair to someone like me🙏❤️ 9 Reply @erickgauthier3556 @erickgauthier3556 1 year ago (edited) Covid made me reconsider my life priorities and made me decide to go back to school and study biochemistry and molecular biology. I've read some of your works about the expression of 3 of 4 yamanaka factors in mice and it made want to focus my studies on trying to prolong human life / quality of life. Thank you! I feel like our current lifespans are a bottleneck to our civilization's advancement. Imagine what could be if our greatest minds could live and thrive for 30-40 more years in their prime. 3 Reply @robertmariano @robertmariano 1 year ago I first heard of the book, Lifespan, on the James Altucher podcast at the start of the pandemic. I bought the book and I talk about the concept that aging should be treated as a disease. I like that you have a podcast/ YouTube presence. I appreciate that the emphasis is on living healthier with more solid science Reply @Gunrun808 @Gunrun808 1 year ago I eagerly await every Monday for Andrew Huberman's life-changing podcast. And now you're telling me that I get another podcast on Wednesday? Amazing! 9 Reply @markd6838 @markd6838 11 months ago Thanks for all the work you do, your research, your book and the podcasts etc. It's much appreciated. 1 Reply @YogionaJourney @YogionaJourney 1 year ago Such an educational podcast! Thank you so much for what you are doing 🙏 In your book you mentioned that in Hebrew there is a phrase "till 120" when people greet each other every birthday. We also say in Hebrew "Lechaym" which means "to life" every time we raise our wine and cheers. So, thank you for improving our quality and quantity of LIFE. 4 Reply @paulcamdar4170 @paulcamdar4170 1 year ago This is simply incredible. Thank you Dr. David Sinclair. 25 Reply 1 reply @theqsanity5797 @theqsanity5797 1 year ago Huge fan of science, huge fan of academia, huge fan of Huberman podcast, and now huge fan of this podcast as well!! So excited for all of this! 1 Reply @beccapetit8431 @beccapetit8431 1 year ago Thank you greatly! The fact that aging can be stopped and reversed is amazing! I love that we have geniuses like you David who care to share this information in a simplified educational and applicable way! You and Andrew Huberman are in my top podcast favorites! Thank you again and please keep it up. 1 Reply @ChefGracesPlace @ChefGracesPlace 1 year ago Anyone else wondering if Matt aged backwards in the Horvath clock, too? His skin is flawless! So excited for more episodes. Thanks for doing this guys. 4 Reply 1 reply @brooklynp2108 @brooklynp2108 1 year ago So glad I found this! I plan on listening to more episodes. I’m really interested and invested in my own health as I had a liver transplant and want to live and be healthy as long as possible! Keep up the good work and God bless you for it! 🤗 Reply @turkishromeo83 @turkishromeo83 1 year ago Huberman Lab & Dr. David Sinclar, absolutely the Best of Best 🙌🏼 Thank you so much for sharing all your knowledge for free with us 🙏🏼 14 Reply @luukiInter @luukiInter 1 year ago Wow That was great conversation. I saw your conversation with Andrew Huberman but I found it just too bit complicated for a newbie to digest TBH, but this podcast is different. I feel like you and Matthew have a power to propagate those complex topics to people who have never heard/read about this stuff. Cant wait for the next podcast! Thank you for that! :) 27 Reply @renniev9006 @renniev9006 1 year ago Thank you so so much for bringing this to the world. Dr Sinclair, you are a gift! And Mr LaPlante, thank you for the questions you bring to the discussion. It really helps reiterate and clarify the information. Thank you both so so much! 4 Reply @adams6545 @adams6545 1 year ago Waiting an entire week to hear the next episode is aging me significantly 😂 fascinating stuff and can’t wait to hear more! 12 Reply 1 reply @dylan8487 @dylan8487 1 year ago I discovered you thanks to Andrew Huberman, currently reading your book and am hyped for this podcast!. I have a feeling its going to be an amazing one. 19 Reply @WyattFL5 @WyattFL5 1 year ago Dr Sinclair has the rare ability to explain complex science in every day language. He’s absolutely one of my favorites, along with Dr Rhonda Patrick. Looking forward to future episodes! 1 Reply @cttofr @cttofr 1 year ago Can you do a podcast on development of children? The acceleration of aging during puberty seems to be somewhat polar opposite to the idea of fasting during adulthood. What ideas come to mind when we say “skip a meal” to a 25-45 year old vs to a 7 yr old, 13 yr old, etc? How do you think about optimizing health in children that are developing in height, performance, etc? Thank you for all you guys do! 26 Reply 3 replies @krizwang7378 @krizwang7378 1 year ago Congratulations Dr. Sinclair! This podcast is going to be epic 👍 17 Reply 1 reply @Basican_pro @Basican_pro 1 year ago Thank you so much for sharing this with us! I’d very much like to also hear your thoughts about ASD, Dr. Sinclair. 1 in 44 children in the U.S. is diagnosed with an autism spectrum disorder (ASD) and this epidemic is global. There is no known single cause for autism spectrum disorder, some say it’s genetics, some say it’s environmental. most children have gastrointestinal, mitochondrial, sensory issues, inability to detoxify and the list goes on. These kids are born with ASD. Please share your thoughts on this disorder, is this related to early aging and can we fix these so called “dirty genes”. As a mother of an autistic 3 years old child, I’m eager to learn more about this and help my child as much as I can. 3 Reply @Xxxsniperxx1 @Xxxsniperxx1 1 year ago I love this so much! How lucky we are to get decades of experience within 1-hour episodes. 1 Reply @natalieaxl804 @natalieaxl804 1 year ago Love you David!! Appreciate all the study and research you do and keeping us in the loop of your discovery 🙏🎊💕 Blessings 🙏 6 Reply @yourenglishupgrade @yourenglishupgrade 1 year ago Excellent stuff! I read the book about a year ago, so I'm really looking forward to finding out what' changed and the greater specifics on how to have a greater healthspan. 2 Reply @esdrasalmeida6047 @esdrasalmeida6047 1 year ago Learned a lot on this episode, i'm definitely watching all of it! I am facinated on how much science has developed so far about aging and so enthusiastically about researching it. 6 Reply 1 reply @LABETONETA @LABETONETA 1 year ago Excellent, first Andrew, now David, life can't be better! Cheers for science! #scienceRules! 25 Reply @tygrera @tygrera 1 year ago I am so glad that this is happening, I've been a fan for a long time, absolutely love your book, much love from the Netherlands 6 Reply @krevoyteam @krevoyteam 1 year ago Can't tell you how happy I am that you decided to do a podcast/youtube channel Dr. Sinclair...way overdue in my opinion but I also understand you are a SUPPER busy man and so grateful for you 2 Reply @miloradmilutinovic7691 @miloradmilutinovic7691 1 year ago (edited) He finally got his own channel, was much more difficult than to reverse the aging 😂 15 Reply @xelaklement3367 @xelaklement3367 1 year ago (edited) I remember about 20 years ago when I still went to school and we didn't have all this great information that is now available online, I often said "aging is just a disease, we could be immortal" and everyone said I was stupid and laughed. Thank you so much Dr Sinclair for your amazing work ! I am looking forward to your future podcasts. 1 Reply 1 reply @Julia-qm7xg @Julia-qm7xg 1 year ago "A turning point in medical history." This is absolutely fascinating! 7 Reply 1 reply @vickydaisy1905 @vickydaisy1905 1 year ago Happy New Year Dr- David Sinclair. Thank you for developing the podcast. Amazing contents to be followed. 14 Reply @rosianaeo9380 @rosianaeo9380 8 months ago Very insightful Professor, “we owed it to our family and society to be as healthy as possible.” 🙏 Reply @jaxnaturals @jaxnaturals 1 year ago This is an eye opening moment for humanity! Completely enthralled with this and will be waiting for every episode! Subscribed! 1 Reply @melissaebbert3844 @melissaebbert3844 1 year ago Yes!!!!! So excited for this! Just started taking NMN a week ago and have been feeling so full of positive energy and able to focus so much better! Thank you David for sharing more of your mind with us!! 3 Reply 2 replies @RosyRosieRose @RosyRosieRose 1 year ago You're absolutely right, age is a disease and we weren't designed to suffer from it, but as our free will dictates, we sometimes miss the target and focus on things that aren't well for us a a species. It is so faith-strengthening to hear this from a super-accomplished geneticist. Reply @sciencensorcery @sciencensorcery 1 year ago (edited) This is all very exciting stuff! I would like to hear you speak on the ethical and philosophical ramifications of this. While of course slowing and reversing aging — and certainly preventing disease — sounds great, the idea of everyone living forever honestly sounds pretty terrifying. Not to be a total cynic, but it seems like the turnover of life is an important part of the progress of our species in so many ways. If people suddenly start living indefinitely, no longer leaving jobs or positions of power but just continuing to grow and hoard wealth, how will that affect upward mobility? As those people maintain their power for decades (or centuries?) longer, how much more stagnant could social change and progress become? How will it affect the global ecosystem and climate? What about people in developing countries who don't have access to even the low-cost suggestions you make? Could the ability to deliberately age or de-age a person be used for evil (as a punishment, for instance)? Again, I'm not trying to be overly negative, these just seem like very important questions we should be asking and addressing if this is actually where our species is headed, and I'd be interested to hear what you have to say about it. 30 Reply 6 replies @brittneytan8213 @brittneytan8213 1 year ago (edited) I can't wait for the next episode. This topic is near and dear to my heart, i want to live forever, or as long as i am able. I enjoyed the podcast, I never knew you're so funny Dr. Sinclair! 33 Reply @liu123 @liu123 1 year ago Thank you for your work and sharing this information. This is truly inspiring and please continue to be motivated by helping humankind! 1 Reply @musicayaudiolibros432 @musicayaudiolibros432 1 year ago This is amazing stuff. Kudos to Dr Sinclair for sharing this with the world! Looking forward to watch the rest of 7 episodes. Reply @janisgs @janisgs 1 year ago (edited) Dr. David, I have been following you for ages already, so happy to see you starting your own Podcast. Looking forward to every moment with you. 2 Reply @alvaromengual6829 @alvaromengual6829 1 year ago AWESOME!!!! I see great success for this podcast! Maybe the Science behind aging got its iPhone moment!!!! Great work guys I can't wait to see future content and the result of future research! By the way your mics sounds great however, the mic captured a little bit of eco form the room. I already subscribe and visit your sponsors so that you guys keep building the podcast. 2 Reply @kotrynarutkauskaite6704 @kotrynarutkauskaite6704 1 year ago Amazing!! I came across this podcast by accident. I read the book one year ago and Im so happy you going to talk on it more and explain and expand it! Excited for the next episode Reply @colinyoung3685 @colinyoung3685 1 year ago Looking forward to following this podcast. May it be fruitful with a long lifespan. 11 Reply @martinahollearn9538 @martinahollearn9538 1 year ago 'I've listened to all episodes and I LOVED all of them. Dr. Sinclair has a lovely voice for podcasting and it's fun to have the two hosts bounce ideas off each other an guide the conversation. Listening to the episodes have been a major inspiration for my personal and professional life and further motivates me to study neuroscience. Please keep working on new series!! Reply @johncarlrankin479 @johncarlrankin479 1 year ago Well Done David! I have been following you for years, as you know. Now is exactly the Right Time to help everyone feel better about their future, and the fact that this is All Possible. Looking forward to the next episode! Much Love & Best Wishes Always, brother. 1 Reply @guitarsz @guitarsz 1 year ago Way to go David! I've watched many of your interviews on Rogan, and Lewis Howes and Impact Theory, glad to see you made your podcast! Congrats! 3 Reply @andreacrouch36 @andreacrouch36 1 year ago (edited) I’ve been following you for a long time. So happy that this has started. I just wanted to say and I know that you’re well aware, the pharmaceutical companies are going to try to buy you or destroy you. I don’t see any way around it. Thank you so much for everything you’ve done I’m 57 people think I’m 30 Reply @Alex24998r @Alex24998r 1 year ago Thank you Dr. Sinclair and to your colleague for starting your own podcast- I have been following your youtube broadcasts for 2 years now and find it fascinating. If you require any volunteers for your work - I am ready, thank you :) 4 Reply 1 reply @BetterHumans @BetterHumans 1 year ago Incredible, loved all of it..got some amazing new information for example the HbA1c and how Metformin can help. My levels were at 5.6% when I had my first Insidetracker test done last October so will be interesting to see what they are at soon. Can't wait for the next episode! 3 Reply @armieflores6064 @armieflores6064 1 year ago I have been following you Dr. D. Sinclair, so excited to hear all brilliant information for longevity and healthy life.Thank you an awesome work with your team and sharing it to us. 2 Reply @wanderingstar9322 @wanderingstar9322 1 year ago (edited) I've been meaning to watch this video series for a while and I finally got around to it today. Having watched this first video, it got me excited and I'm looking forward to the rest! Thank you Dr. David Sinclair and Mathew LaPlante for sharing this information with the world 🙏 Reply @forcela000 @forcela000 1 year ago Wish you good luck with this new endeavour! I've started reading your book recently, so interesting and fascinating can't wait to learn more 4 Reply @stevef6523 @stevef6523 1 year ago Would love to hear your opinion about Resveratrol versus Pterostilbene in one of these future podcasts David, given your extensive experience with Resveratrol. Thank you for doing these, they're fantastic and I'm definitely looking forward to your future work to help the lay public like me to make use of this fantastic work. Reply @Petewalker907 @Petewalker907 1 year ago I have been looking forward for your podcast for a while now and I am happy it is finally here :) thank you and keep changing the world for the better :) 3 Reply @Corrans @Corrans 1 year ago I read the book and now am thrilled to listen to this. Thank you for bringing this to us for free! Reply @mariclaretpatton9412 @mariclaretpatton9412 1 year ago I am chronologically 61. Will I be able to benefit from these discoveries and avoid further ex-differentiation? This is so fascinating. I am going to watch the entire series. Thanks you gentlemen! Reply @angelasaarloos3991 @angelasaarloos3991 1 year ago David Sinclair is such a bright mind but also a kind human being! I'm so inspired. 1 Reply @michaelshover @michaelshover 8 months ago This is amazing to listen to and see the interaction between the two of you. I remember a few years ago I was taking a microbiology and anatomy and physiology class at the same time. I remember the microbiology class was going in depth of the cell and learning about DNA, genes, and each section of the strand with how they link together with the histones. For some reason I became interested specifically with this and how X differentiating and mutation of cells leads to cancer and the aging of the body. The anatomy and physiology class went into some of this as well because it was the second level of the class which was more in depth of the physiology relating to the anatomy. Reply 1 reply @olav-rasmusvorren7316 @olav-rasmusvorren7316 1 year ago Very good podcast, appreciate you making this available in such an informative and interesting format! 1 Reply @bernardradcliffe6240 @bernardradcliffe6240 1 year ago I am looking forward to the next 7 podcasts. And I can't wait for the new discoveries just around the corner that will change everything we know about age related diseases. 3 Reply @A7md02 @A7md02 1 year ago Can't thank you enough for the huge amount of information we get from you Dr. Sinclair. I wish if the video was supported with pics for what was described. 1 Reply @super_heroes @super_heroes 1 year ago (edited) David Sinclair has helped me be a healthier and younger person since I was in back in 2020. I’ve implemented intermittent fasting and mild NAD+ boosting precursors like NR and NMN and I’ve been consistently using mineral sunscreen as of a month ago. I read his book Lifespan and I’m starting to read the book again it’s such an interesting read and learning about his family, especially Sinclair’s grandmother, Vera’s positive influence and motivation towards his life. I’m 20 now by the way Reply @aeonproelium8474 @aeonproelium8474 1 year ago Great podcast. Seen you, David, on Rogan and Andrew's podcasts and been waiting for this to happen. Love it and look forward to more! Thank you 1 Reply @AdamCarsonX @AdamCarsonX 8 months ago Dr. Sinclair, based on a comment you made, what's the reason people lived so long before the Biblical flood and started getting shorter lifespans after that? As a side note, THANK YOU!! I've been following your research for several months now and am beyond excited... It's like I'm see another life in front of me literally, and with youth. It's mind-blowing to say the least. 1 Reply @dianakautzky931 @dianakautzky931 1 year ago This is such a fantastic podcast. Not only have I signed up for athletic greens and inside tracker I listened to the podcasts over and over. They are excellent and I hope I am changing my lifestyle to Live a longer and more quality life. Me wish us for more podcasts to be developed. I’ve listened to all 8! And I want more. 1 Reply @porchzombie @porchzombie 1 year ago Can't wait to hear the rest of this series... this is some amazing stuff! 3 Reply 1 reply @meredithmoore9779 @meredithmoore9779 1 year ago I went to my hairdresser yesterday, we are in Perth Western Australia, and was telling him all about the first podcast. He's nodding away, I know, I know he says. He rushed out to get his phone and he is listening to Lifespan on Audible. Fantastic! I'm really looking forward to this series. Thank you Dr Sinclair and also to Professor Huberman for your knowledge and making it accessible to the general public. Oh and I love listening to an Australian accent (even though it is very light). Reply @vadymkodryan3974 @vadymkodryan3974 1 year ago Thank you very much for doing this! Exciting and illuminating! I haven't read the book yet but I am going to. I am indeed confused about how telomere lengthening and hormone replacement therapy fit or don't fit into this information theory of aging. Likewise, some supplements may be hurting in excess amounts and helping in proper amounts (vitamin C and vitamin E). Ultimately, one thought has been troubling me for years: with knowing so much about the human body and understanding so much about genetics scientists cannot give clear-cut recommendations on how to exercise, what to eat and how to organize your life. I have high expectations that this series with bring order to this mess. Reply @israelhydroponics8659 @israelhydroponics8659 1 year ago Thank you David for all that you are doing. Amazing talk. Inspirational. Sparks hope for a bright and long lasting future to humanity. 1 Reply @aidasr.6387 @aidasr.6387 1 year ago (edited) I'm so happy to see the podcast's finally out. Great work you're doing there. I've read the book, seen other shows with Dr. Sinclair and each time I'm a bit worried that maybe I will hear the same stuff again. Nope. Each time there's something new. Something even more detailed, from a different angle, new findings presented and so on. Each time I get another boost of motivation and another boost of optimism about the future of humanity :) really cool stuff and truly mind-blowing! Can't wait for the next episode already. 12 Reply @jeen3493 @jeen3493 1 year ago Hello doctor! I've been waiting for this for a while, really happy to finally see it! My question for you (or anyone on the production team) is: are insidetracker and levels available in Europe? Specifically I'm in the Netherlands, and I would love to try both of them! Thank you for the amazing podcast :) 18 Reply 2 replies @SamPattersonRealEstate @SamPattersonRealEstate 1 year ago (edited) Amazing content! Thank you for starting these! Have purchased the book-which is amazing! 15 Reply @andreipopa5540 @andreipopa5540 1 year ago Great episode. Looking forward for more! 2 things should be adressed: How to balance fasting with geting enough nutrients and what foods are the best. What are the foods/extracts that are similar in effect to the substances you recommend. Like is grapeseed extract a good alternative for Resveratrol. I think this would be useful for people in poorer countries. Also, a PDF at the end of the podcast with the main points would be awesome! Keep it up! Live long and prosper! 1 Reply @anjolotumaclas3117 @anjolotumaclas3117 1 year ago Amazing!! Great idea to have Matthew on. Keeping it simple, many of these kinds of podcast where there is two experts makes the conversation very demanding to understand. Reply @andre_uag @andre_uag 4 months ago This is impressive. It gives me a profound sense of gratitude to be alive in this era after I've come across to Dr. Sinclair. Is there anything related to noise induced hearing loss? Not as a a consequence of aging Reply @lukejagodzinski @lukejagodzinski 1 year ago Great podcast! Not only great subject but it's really fun to watch 🙂. And it's just in time for me 🙂. I'm currently fasting 16/8 for the last 41 days. I just bought MNM and resveratrol. Planning to buy Berberine as the replacement for Metformin. Btw. does Berberine have the same benefits to your health? 1 Reply @sleepmeditationsandrelaxat5681 @sleepmeditationsandrelaxat5681 1 year ago You have touched the lives of millions and I hope the medical research breakthroughs will one day change the course of humanity for the better. Thank you and I will keep on following your work 1 Reply @OzoneFineArtVentures @OzoneFineArtVentures 1 year ago Great podcast! This is so exciting to see podcasts like yours, Andrew Huberman, Lex Fridman, and others who are bringing up-to-the-minute science to the general public. Thank you so much for sharing, really enjoyed you on Andrew's podcast, and will be watching/listening to yours weekly now too. By the way, the addition of Matthew LaPlante is a great idea. It's nice to hear the banter as opposed to a singular, lecture style presentation. Cheers! 6 Reply @EPTFForsyth @EPTFForsyth 1 year ago Dr. Sinclair/ and Professor LaPlante you have helped me change my life. I am no longer over weight, no longer have Diabetes/DM2. And I finally feel/ look better. That was a long winded way of saying thank you. 1 Reply @kongkongball1 @kongkongball1 1 year ago Thank you so much for starting this podcast. Everyone should know this information. Reply @mariamorris954 @mariamorris954 1 year ago I discovered Dr. Sinclair when Andrew Huberman had him in his podcast, love and appreciate how they are informing us. Thank you, gracias❤ 3 Reply @stefanobertini7116 @stefanobertini7116 1 year ago È veramente eccezionale , come rappresenti sistemi complessi per la maggior parte degli uomini su questa terra , in un modo semplice e comprensibile . Siamo ad un passo da una rivoluzione per l’umanità , inimmaginabile solo pochi anni fa . Per moltissimi inimmaginabile ancora oggi ! Ho voluto scrivere in italiano , per testimoniare quanto sei apprezzabile David !❤️ I wanted to write in Italian, to testify how appreciable you are David!❤️ Sb Reply @stevelacy8342 @stevelacy8342 1 year ago This was a great podcast, thank you ,can't wait for the next one. 6 Reply @avrilvillodres3733 @avrilvillodres3733 1 year ago Thank you for sharing your knowledge Dr. Sinclair. I really appreciate what you and Matt are doing. I'm looking forward to your next 7 episodes in this series. I think Matt asks really good questions but the interruptions can get a bit jarring at times. Can you maybe tweak your format a bit so Dr. Sinclair can finish explaining then just do a "going back to what you said earlier" just like Prof. Huberman does in his podcasts? You guys are a treasure! 4 Reply 1 reply @alejandraalvarezdetoledo1783 @alejandraalvarezdetoledo1783 1 year ago Thank you thank you David Sinclair and co host for speaking so clear for us that are not on the scientific world. I was a mother at 44 years so my interest in keeping alive with my best quality possible as long as i can is a huge wish so i can share with my child many things in his adulthood. Hope as what you say, devices and everything else will be more accesible for us in the future, but we can start with what´s in our hands and that i have been reading/listening over the last years and it´s what you talked about on your episode 2 which i loved too. I´m excited for the next episodes!!!!! 1 Reply @saptarshisarker @saptarshisarker 1 year ago (edited) Thank you David sir for all the research You will surely change humanity forever I want to be immortal 2 Reply @efilnikufesin @efilnikufesin 1 year ago (edited) This Podcast would be here for Centuries. And wating for this 2nd epeisode to make it a million subscribers. Thanks David for giving us Facts ,logic and wisdom . Reply @lanetteglass8192 @lanetteglass8192 1 year ago So happy to see this. Been following anything Dr. Sinclair does for a year or so. 1 Reply @McNastySlam @McNastySlam 1 year ago I’m so stoked you have a podcast! Subscribed. Can’t wait to hear more of your thoughts on this platform. 2 Reply 1 reply @SebastianNiemann @SebastianNiemann 1 year ago Amazing podcast 🙏❤️- already looking forward to part 2 5 Reply @timvw01 @timvw01 1 year ago Great podcast, very interested in the following episodes. Well done!💪 2 Reply @simpleman7203 @simpleman7203 1 year ago It is actually great that David has a podcast now. Media would gladly take that saying about immortality and make a big headline, false hope or over-skepticism while here he can explain his take on it himself 1 Reply @terigormley4061 @terigormley4061 1 year ago I've read your book 3 times. I'm absolutely inthralled in you and Your co-host. Please, please, please keep going. I cannot wait to hear. more. I'm following your supplements, and started taking 2 different peptides, I've been so good my whole life, vegan, runner, supplements, but was Dx with breast cancer. I was a career firefighter in Sacramento for 34 years, and the toxins may have added to my Dx. I would love to bounce a few ideas off of you? Reply @followthatstargirl824 @followthatstargirl824 1 year ago (edited) Hello Dr. Sinclair and Mr. LaPlante! I manifested you in my life. I am forever 27 and thanks in advance for sharing with me the way. I'm just about to start this episode and I look forward to being in this journey with you! Sending love from Manila ❤ Reply @bluehairkim1 @bluehairkim1 1 year ago (edited) Complicated topic, I need to spend more time on it but you guys did a wonderful job explaining it to someone with no background. I was pretty skeptical on this idea and a lot of doctors online are too. All they need to do is listen to your podcast and they will have the background to understand. The better grip the average Joe has on this the better we will have of explaining it to those that don’t want to listen or simply not that interested and are kind of caught up in lifestyles that are killing them rapidly. This springs so much hope for my child’s generation, we can try to extend the life and the quality of it for those that are here with this knowledge and let us live out the rest of our life with a higher quality, by my child’s generation or his children’s children we’re going to see some really serious changes with this knowledge. I wish I could peek into the future 200 years from now then again at 1000 and 2000. We may survive this planet yet, all we need to do is stop killing our own through things like the poverty plate lack of healthy and hygienic sleeping conditions materialism and capitalism. If a rich person can build a brand new house after 15 years and tear down the old one why are we sticking people in homes so old they have mold, toxic mold? Greed… The root of all evil. When someone believes they deserve more than others because they have been fed the idea we injure our own species and ensure our demise. You can’t exactly blame the planet for trying to purge us now can you, not if we can’t get our shit together. 1 Reply @sammyhoffman71 @sammyhoffman71 1 year ago So excited about this series, thanks for giving up some of your time to help us extend ours 4 Reply @arthurberry7666 @arthurberry7666 1 year ago Having lost 2 brothers at age 59, l hope to live the years they lost, and what better way than to follow Dr Sinclair and his science...which l am doing, having purchased his book and watching Lifespan podcasts, amongst others devoted to the science. 2 Reply 1 reply @playboxfan @playboxfan 1 year ago Thank you for making this channel, it's now easier to get educated from the source directly. 1 Reply @singhashon @singhashon 1 year ago I have been following this research for a while now but everything I hear the science and frameworks around it again and again just makes me more and more excited 1 Reply @ericmikkelsen @ericmikkelsen 1 year ago So glad you're keeping us up to date! Thank you so much! Could you please put together a terminology glossary that could be understood by a lay person not in your field? Thanks again! 1 Reply @oleksiygutor9327 @oleksiygutor9327 1 year ago What are we going to do with OVERPOPULATION? Been following Dr. Sinclair for a few years now and even donated to his research over at Harvard MS. Currently also taking a few supplements and feeling great. Thank you Dr. Sinclair for your work! 1 Reply @minister1005 @minister1005 1 year ago So excited! Thanks for doing this! We always needed more ❤❤ 10 Reply @debelvidge792 @debelvidge792 1 year ago Such a great podcast thank you !! I also read your book which was awesome as well! 1 Reply @edisonclaro5363 @edisonclaro5363 1 year ago brilhante work Dr. Sinclair. We are waiting for much much more. Thanks now we have our own podcast we got information from the real source. 1 Reply @AngelPerez-un8ne @AngelPerez-un8ne 1 year ago Me encantaría comenzar por lo que podemos aplicar en base a estudios cientificos, creo que mucha de la información tiene que ser divulgada para ir sensibilizando a las personas 2 Reply @donnasullivan8569 @donnasullivan8569 1 year ago Thank you Dr Sinclair- in 2018 my Mother Ruth passed away at 103. A perfect memory to the end- decades of Bridge playing and fasted every Monday to keep her weight-she was amazing! Reply @ahunt0182 @ahunt0182 1 year ago I think it's very helpful infomation, especially for medical doctors who really want to treat their patients. Thank you so much and keep up the good work. Reply @carpediemjonah8110 @carpediemjonah8110 1 year ago (edited) What a great way to go around the mainstream medical establishment and present the greatest research in real time directly to the common man. Your research is benefiting mankind at speeds unheard of, and imagined by the mainstream. The "mainstream" is withering from old age. 18 Reply @DrGayleDelaneyDreams @DrGayleDelaneyDreams 1 year ago HOORAY! At last, Dr. Sinclair is unfettered by interviewers who feel they need to ask the same introductory questions and he is free to move on to the next level of explanation. Matthew is so well-informed and knows how to compliment David's points and how to ask interesting and useful follow-up questions. The lighting and sound are good, and the introduction to and the updating of the work is well thought out. THANK YOU! I shall be able to share these videos with a much broader spectrum of my friends and colleagues while learning more and more! 1 Reply @onelifenz @onelifenz 1 year ago This is fantastic work! Thank you for bringing this to mainstream. I'm not sure where you would want questions posted - but I notice that you mentioned drinking tea, coffee, water in regards to keeping hunger at bay when fasting (in #2). Are you at all concerned with taking nutrients (ie the Athletic Greens) and coffee/black tea at the same time in regards to reducing nutrient absorption? (or do you space this out?) Reply @catherinerossba-fineartma-6619 @catherinerossba-fineartma-6619 1 year ago (edited) Bravo — love seeing you here and your fabulous colleague Matt! A match made in Heaven! I can’t wait to hear the valuable info that you/Matt are making this important contribution accessible to average/normal people— I so appreciate your integrity and authenticity Thank you thank you thank you 🙏 2 Reply @teddybear1968 @teddybear1968 1 year ago Thank you for such a great information. Very educational! Love your channel. Reply @soulofjo @soulofjo 1 year ago (edited) I absolutely LOVE this. Thank you! especially i love the FACT that we are all made of same 'material' 👌💙if every human being would understand this, things would be totally different than now. Reply @dennis200620062006 @dennis200620062006 1 year ago Amazing dr Sinclair! Love the work you're doing. 3 Reply @user-rx2pw3ft7i @user-rx2pw3ft7i 1 year ago Absolutely awesome podcast, keep em coming! Reply @rhysthomas4051 @rhysthomas4051 1 year ago Facinating work and appreciative you making it so accessible! Thank you 🙏🏻 Reply @natalieschulz6537 @natalieschulz6537 1 year ago Great podcast! I am surprised that your youthful appearance is not addressed in this podcast or Dr. Huberman's podcast. I would like to know to what degree this has to do with the supplements you take (like the NMN and the resveratrol you talked about), and if you looked older at age 40 when you started taking them. I am currently a second year student going for a bachelor in Neuroscience and have always loved everything science related, specifically biology and the brain. Super excited about these podcasts! 2 Reply @placewhereiamnow4483 @placewhereiamnow4483 1 year ago Very inspiring people and big help to the world,you guys are cool and awesome! Love,love,love this Channel!! 1 Reply @sarah-anneperry6932 @sarah-anneperry6932 1 year ago (edited) My year's resolution this year is to keep hope alive and this content is coming in handy. 2 Reply @jazsandhu91 @jazsandhu91 1 year ago Let's all hope this podcast spreads like wildfire around the world! 4 Reply @bi2u4787 @bi2u4787 1 year ago This is some profound information on health and longevity for anyone who wants to improve their lives! 1 Reply @violetagrozavu @violetagrozavu 1 year ago Finally Mr. David Sinclair! I am so interested in this topic, I want to be in a better shape and state of mind as I move through life! Thank you so very much! Good luck! 🤗🤗🤗 1 Reply @javiergarcia7807 @javiergarcia7807 1 year ago Congrats for the channel, it´s amazing the contribution you are doing and you are going to do to the world!!!!! Thanks a million. My unique query: can people recovering from cancer use nmn? 2 Reply @user-yc3xg3jd8k @user-yc3xg3jd8k 1 year ago What a great scientist! Thank you for your work! 1 Reply @rachelstark8002 @rachelstark8002 1 year ago Even if most people don't believe longevity, they should still support it coz in fact we just have one life after all. Living up to a hundred and being still healthy is beyond priceless. I'm up for Dr. Sinclair's NMN supplementation. It's hard to prove something if you don't experience it yourself. Thanks to Vitruvin Health supplementation, I'll never have to worry about aging and the age-linked illnesses. Reply @robertadams3666 @robertadams3666 1 year ago Didn’t want this to end. Look forward to the next one. 3 Reply @mathmom18 @mathmom18 1 year ago (edited) So glad you are speaking to this important topic and in particular distinguishing animal trials from clinical research. I direct global clinical research in solid tumor oncology and many theories that show potential benefit in preclinical research fail safety and/or efficacy in humans. Sometimes what's good for a mouse is only good for a mouse. Also regarding diet and health, what I tell people is to look around and see how many obese people do they know who are older than 70. 1 Reply @iDeist @iDeist 1 year ago Been waiting for your podcast for a few years now. Glad it is finally here for a healthier 2002 and future. Cheers! Reply @MissJete21 @MissJete21 5 months ago I have been reading and listening, following David all really for 7 years. Amazing! So sad that nothing like that is happening in Europe… 😢 Reply @j.m.r.3902 @j.m.r.3902 1 year ago Superb podcast. Forty thousand years of evolution and we've barely even tapped the vastness of human potential. 1 Reply @michaeldubruyn7965 @michaeldubruyn7965 1 year ago I wish more people would realize how amazing this is, I think this research will be as significant as the AI revolution if not more. Reply @constancechan7748 @constancechan7748 1 year ago It is a bless that the new year starts off with lifespan with Dr.David Sinclair podcast ! 7 Reply @alexanderpopp2327 @alexanderpopp2327 1 year ago incredible duo! super excited for what's to come. 1 Reply @shirleyanderson5644 @shirleyanderson5644 1 year ago I appreciate the info and plan to listen to the entire series. If things have changed since you wrote your book, I wonder how inflammation fits into the picture. I think you're talking about challenging your body to suffer a little, and that that will bring about some beneficial, anti--aging adaptations. That seems contradictory to the previous advice to keep inflammation down by going to bed and waking up and eating at set times so your body doesn't go into a state of inflammation. Thoughts? 1 Reply @markmark48 @markmark48 1 year ago Can't wait for the next episode, please keep these coming! 1 Reply @MatoMkenya @MatoMkenya 1 year ago What a way to start 2022. This is epic. Can't wait for the other episodes. Thank you Dr. Sinclair for the info all the way from Kenya. 1 Reply @braian4478 @braian4478 1 year ago (edited) Finally it's here!!, congratulations David and team! And thank you very much for share such a useful information! 2 Reply @zinkarius7 @zinkarius7 1 year ago Thanks for all your work Mr. Sinclair 4 Reply @nandantavkar @nandantavkar 1 year ago (edited) David Sinclair podcasts are like between two ferns. Love the brilliant embedded humour. 1 Reply @celineemora6357 @celineemora6357 1 year ago New subscriber. I can't wait to listen to the next episode. Everything on this episode was mind blowing, I enjoyed it so much 👌🙏🙌 1 Reply @catmom6572 @catmom6572 1 year ago Thanks Dr Sinclair. I have read (listen the audible version) your book many many time， I'm so happy to hear your update after 2 years I bought the book. 1 Reply @rorivero @rorivero 1 year ago What a gem of an interview! 🔆✨ 1 Reply @sebpig9956 @sebpig9956 1 year ago Thank you Dr Sinclair, great podcast. I love the chemistry with matt. You talked in your interview with Huberman about ketosis and how couple of spoons of yogurt would not break your fast. If I consume nuts rich in fat but low in protein and carb for breakfast, do I get the same outcome? Thank you. 2 Reply @callofthedark @callofthedark 1 year ago (edited) The wait is over.. My guru is Live. No words can ever comfort me to express my gratitude for all that I have received from life especially from my Guru “Dr.Sinclair”. I have been fortunate to have followed you since the past 4 years and all that I can say is that I am a 37 years chronological getting oldman but who looks like a 27-28 years young & health. It’s because of following you and your lessons on longevity I have been able to successfully reverse my biological age to live a robust & active life till a 100. As Dr.Sinclair once said “The one who will live till 150 has already been born”, I will do my best to be among the set of people who do. In the end can’t wait for your new Book and listen to the remaining 7 episodes of this podcast series. I bow before you for all that you have taught me.🙏🏻 3 Reply 1 reply @Activ80 @Activ80 1 year ago I have only recently become aware of your work. I am 80 & from what i can determine from briefly watching this (will continue) is that I have worked out some of the determining longevity factors myself by lifestyle experimentation without the science. If you monitor these comments I would like to be able to contact you to discuss what is now becoming of primary importance to me at this stage of my life. What would be the best way to get in touch? Reply @Bolangel @Bolangel 1 year ago Mind blowing ! I have been watching videos about aging process for over a year now and I love every one of your interventions - but this is just mind blowing, the first one in which the concret biological process is so clearly explained ! Great work Reply @aliciamarie7951 @aliciamarie7951 1 year ago I've been waiting and hoping you would start a podcast. I've read Lifespan and watched as many other podcasts Dr. Sinclair was on. Thank you. Reply @ishtar0077 @ishtar0077 1 year ago It's so wonderful to see new podcasts. I'm very excited about it 🤗 2 Reply @CazzoneMagrolino @CazzoneMagrolino 1 year ago (edited) I'm glad Huberman interviewed you, otherwise I wouldn't have discovered you and this great podcast. I hope you will continue with this podcast. 2 Reply @onna14Marta @onna14Marta 1 year ago Thank you for all the work - this is perfect! Reply @Camaxtli1000 @Camaxtli1000 1 year ago Instantly liked and subscribed. Loved the book and can't wait for the next. 4 Reply @Tiernansteatime @Tiernansteatime 1 year ago I’m dying to know what you think about bodybuilders and powerlifters eating habits and how that affects aging. Typically we have to bulk and eat an insane amount of food in order to gain weight & muscle for competitions so I would love to hear your thoughts on how that would affect our life spans. Reply @hobbyfarmer1452 @hobbyfarmer1452 1 year ago I watched this video the second time. I had much better understanding of the content. Of course, I had watched numerous videos that Dr. Sinclair was interviewed. I just can’t thank David enough for educating the public with such an important issue. Reply @kathleenstewart44 @kathleenstewart44 1 year ago Thank you! If you have time to discuss muscle wasting, specifically in younger people, and how that fits into your model, I would greatly appreciate it. 1 Reply @lubainaibrahim7771 @lubainaibrahim7771 5 months ago Dr. Sinclair, I am glad you decided to take to the platform. I am excited to see what you have to say. A small feedback, I think a structured format with a monologue can fit much more information than the question answer one. And it seems like the question and answer format in this video seems slightly haphazard and feels like we are jumping from one topic to the next. Regardless can’t wait to learn more ! Reply @ty-lim @ty-lim 1 year ago If Dr Sinclair is mostly right he will be one of the most if not the most impactful person for humanity. I look forward to following him closely. His book Lifespan has been one of the most impactful for me. Thank you. Reply @randyuno1453 @randyuno1453 1 year ago Thank you so much for this great podcast! 4 Reply @thetranslated5736 @thetranslated5736 1 year ago Great work. Looking forward to future episodes.😁 1 Reply @heracles89 @heracles89 1 year ago As well as donating to the Harvard school, it would be great to see how we could collectively advance this goal to tackle ageing - how do we channel more capital (both intellectual and financial) into this space? 2 Reply @brosan5404 @brosan5404 1 year ago (edited) I watch every interview D.S. does and this is SO much better. MLP is a FANTASTIC interviewer, so grateful for this. 50:24 2 Reply @skypoem5153 @skypoem5153 1 year ago "You act like the caveman with the questions I need to ask myself". Subtle, hilarious. Love it. Thank you for your authenticity. 2 Reply @jimtoomey9522 @jimtoomey9522 1 year ago Brilliant ! Thank you for condensing your research into bite size, understandable chunks ! Reply @seeesh_ @seeesh_ 1 year ago I'm so excited. And happy to see your own podcast, David. Greetings from Brazil 3 Reply @suboticanin96 @suboticanin96 1 year ago Thank you for the podcast, it was a joy to listen to. I have a question, if you have the time. Exercise activates SIRT genes, but doesn't it also activate muscle growth pathways? If I understood well those pathways reduce the lifespan and they need to be inhibited. 1 Reply @spiritassociates8695 @spiritassociates8695 1 year ago Sinclair is a science hero! 2 Reply @andrewwalker8985 @andrewwalker8985 1 year ago Is it just me or is David actually looking younger and younger... definitely helps communicate the science of ageing! Reply @LCarefortheworld @LCarefortheworld 1 year ago We are SO lucky that Dr Sinclair is doing podcasts. So many confusing info out there and fake supplements. I bought these near dark brown color resveratrol on Amazon and learned that it was supposed to be white color after watching one of Dr Sinclair’s interviews. Now I don’t have to check different channels to find his interviews and get the facts and the first hand information from himself, Thank you, Dr Sinclair and your “lovely co host” Matt 😆 Reply @jimlawmrcasual @jimlawmrcasual 1 year ago Super podcast. Very informative. Questions: 1) Are you aware of any Canadian companies that would do a DNA methylation profile. 2) If not credible US companies? 3) will this be a feature of Inside Track? Thanks! 1 Reply @umeshchhikara @umeshchhikara 1 year ago While reading your book...I always wished if I would hear everything from you. And here you are. Fantastic. Loved the first episode. Analogy - I also back up as rehab expert for few and only take up challenging cases where the pain persist over years. The fundamental difference btw what I do and what doctors do is same as you explained towards the end. Doctors repair the damaged part whereas I look at the root cause of the problem and start rectifying from there and eventually giving relief to the troubled region. Out of interest, whats your biological age David? I would like to check mine but would rather do it at a proper place - perhaps in my next US trip. I am 47 for now :) 3 Reply @petrabyrne6107 @petrabyrne6107 4 weeks ago (edited) I'm so thrilled now that I can comfortably go without breakfast. Knowing your liver will adjust has made the difference. I'm on 2 meals per day at present, and I stretch out lunch as much as I can. I drink water more frequently which has had other great benefits. I can easily hold out on evening snacks because it would break my 16+ hour fast. I know you are always researching and doing human trials etc, having a better idea why exercising (short periods ok) and a little or a lot of fasting is good on a cellular/DNA level has made all the difference. Hoping for the company levels to come to Australia soon. Cheers! Reply @wythra5183 @wythra5183 1 year ago I'm a subscriber, I came here by the Huberman Lab Podcast. Thanks for doing the interview you did over there, it was incredibly high value and dense. I have a question I've struggled to find an answer to elsewhere: what happens if someone who is in their 30s were to begin taking things like, resveratrol, NMN, and/or berberine/metformin? Is there any danger? I'm 31, but I am a transgender individual, so I feel I missed out on some of my youth (admittedly, I took much worse care of my body when I hated living in it). I just want to maximize my youth, and make the best of what I've got left. To be honest, it'd be nice to feel I still had some 20s in me left! Thanks in advance! 1 Reply @gjmor1 @gjmor1 11 months ago When I first learn that taking cold showers was good for the environment, I thought interesting that makes sense, but I never applied it to my life because I enjoy taking hot showers even in the summer. But when Dr. Sinclair reminded us that cold showers causes the body to produce precious brown fat, that was it for me; ever since then all of my showers are cold, and I’ve adapted to it. Reply @vladimirpekez3702 @vladimirpekez3702 1 year ago Great podcast, looking forward to new episodes 1 Reply @niiicki @niiicki 1 year ago Please keep this series going! Reply @gautamnandu5420 @gautamnandu5420 1 year ago Can’t believe it’s happening I’ve been waiting for this for Such a long time. He and huber man changed my lifestyle completely 6 Reply @marlenem4385 @marlenem4385 1 year ago Finally it is here! Thank you for your Life changing research - Dr Sinclair is a rockstar! 1 Reply @lylan8737 @lylan8737 1 year ago I loved reading your book and i still have wit because i red it twice and still feel like i want to go back and read it. It just make me feel better getting the knowledge. It is my most favorite book. I can’t wait for your next book. 1 Reply @Ruudwardt @Ruudwardt 1 year ago (edited) Eagerly looking forward to the next episodes, however if I am allowed to be impatient, there is a question: wrt mTOR - will the average level matter or peaks? Will it be detrimental to have elevated mTOR after a big meal, but then fast for the rest of the day? In essence, will muscle synthesis be detrimental to lifespan by this mechanism, or will there be a threshold? 1 Reply @popkian @popkian 1 year ago Thank you for this great podcast and the book of course. How can we choose the best brand for resveratol and NMN ?! There are so many product out there but I can not tell which one is good or which one is just low quality. I would appreciate if you can cover this topic as well. 2 Reply @potentialreality @potentialreality 1 year ago I have been looking forward to this. I have subscribed here and David's other channel, I have listened to him on numerous other podcasts, and look forward to reading his books. 2 Reply @vitalrestandrecoveryclinic7752 @vitalrestandrecoveryclinic7752 1 year ago Im so excited for this podcast. Thank you!!!!!❤ 7 Reply @randel14 @randel14 1 year ago I’m so happy you made a podcast, this is going to be grounbreaking! 1 Reply @cristinaferreiraleite4125 @cristinaferreiraleite4125 1 year ago Such a great Scientist! Thank you for sharing your knowledge !! 1 Reply @bradleypoe-laulu433 @bradleypoe-laulu433 1 year ago Thank you so much for this channel I look forward on learning more I myself hope we will take the opportunity of biological immortality 1 Reply @UljanSinani @UljanSinani 1 year ago Great to see your research work crystallise for everybody! Reply @captiongeeza @captiongeeza 1 year ago Enjoyed it, and look forward to hearing more. Thanks ! 👍 1 Reply @ramentabetai1266 @ramentabetai1266 1 year ago (edited) Hopefully they will talk about David's recent economics paper that shows how increasing the lifespan of a population would give trillions to the economy. Just a 2 year increase = 36 trillions. It's called "The economic value of targeting aging". Published in Nature. 10 Reply 2 replies @anetevaska4140 @anetevaska4140 1 year ago Waiting for the third serie! Thank you for sharing your findings! Reply @jackiechang4100 @jackiechang4100 1 year ago Wow! Dr. Sinclair got his own podcast!!! Thank you! 1 Reply @ronaldschmid9631 @ronaldschmid9631 1 year ago Any news from him are always exciting because he instinctively knows already that aging can be slowed down and then reversed. Reply @charliec3241 @charliec3241 1 year ago Type 1 Diabetic since a coma at 18mnths old. Countless seizures, slight brain damage from the seizures back over a decade ago. I've been doing keto and int fasting for 5 years and my health has improved DRAMATICALLY. Defo recommend. Thanks for spreading your message guys. Reply @githubbb8363 @githubbb8363 1 year ago So glad to see this channel finally!!!. Thanks a lot for sharing the details with us. I have a question on NMN and its impact on cancer cells. Read in a few places that it might increase cancer **if we have it already. Is this right? I am totally confused on taking the NMN supplement. Please let us know your views on this..Thanks in advance. 1 Reply @RodrasBurton @RodrasBurton 1 year ago Rise and shine, it's lifespan podcast time! Looking forward to listen more of Dr. David Sinclair's precious info! 💪😁 Live long, stay fit, stay healthy! 3 Reply @jeffadams5413 @jeffadams5413 1 year ago So glad that David is doing his own podcasts. I do have a question. I have been taking NMN and Resveratrol for two years now. But my resveratrol is brown. I heard David say if resveratrol turns brown it is bad to take? Reply @andersjonsson8403 @andersjonsson8403 1 year ago Fantastic information, thanks! I cant wait for next episodes! 1 Reply @constancegoldwing5867 @constancegoldwing5867 1 year ago (edited) I read Lifespan to my fiance before bed each night, and he started dreaming about mice lol. You should bring Dr Eric Berg on this show and have a lengthy discussion! 2 Reply @JasonClowrey @JasonClowrey 1 year ago Great news it’s finally here. First listened to you on Joe Rogan’s show few years back. Started taking nmn and resveratrol and feeling pretty good. What is the best way to take rapamycin? Is that similar to metformin? Thanks again for your insight and knowledge, and all you’re trying to accomplish for humanity 1 Reply @wilsonlam8437 @wilsonlam8437 2 months ago Exceptionally good book. Thank you doctor Sinclair Reply @PA-eo7fs @PA-eo7fs 1 year ago David, please do an episode on bodybuilding and aging the trade off. Often times we want to gain muscle but do not want to activate Mtor and increase aging. 4 Reply @dorel07 @dorel07 1 year ago Congratulations and thank you for officially opening the portal to the New Age-ing Era. 1 Reply @smitadas2001 @smitadas2001 1 year ago Thank you for sharing the details of such valuable research. 1 Reply @wendylou803 @wendylou803 1 year ago Thank you, thank you! - For sharing and educating us on the knowledge! Reply @matthewperkins2950 @matthewperkins2950 1 year ago How do we know that the increased average life expectancy of a type 2 diabetic taking Metformin over a regular person is not caused by them likely being more conscious about their diet? (Avoiding sugars etc.) i’m so glad this podcast is finally here! Reply @mv-h5695 @mv-h5695 1 year ago (edited) So excited to listen to you Dr Sinclair. Enjoyed your interviews with JR and Doc Huberman. Would love for you to chat with Dr Ben Bikman. You both agree on insulin resistance but not on the effect of amino acids on mTor. 1 Reply @sunnyc8679 @sunnyc8679 1 year ago Please do an episode with tips for people who care about building muscle! Shutting down mTOR isn't really an option for us :( 3 Reply 2 replies @DaBulgarianQueen @DaBulgarianQueen 1 year ago Thank you very much for this information, you guys are great. Reply @binsig7706 @binsig7706 1 year ago Thank you Dr. David. I am big fan of your book and research. I follow your every video and podcast. Glad to see your own podcast and channel. I have a question, if my eating window is breakfast. can i take metformin and all supplement in the morning? How to eat only 1 meal and get ? can you share what is in your plate in 1 meal? Is it okay on metformin when you have not eat ?. Please give more info in podcast. 2 Reply @TheHouseElf @TheHouseElf 1 year ago I would love to know how that idea of "giving your body a little bit of fear" can be balanced without overdoing it. Fasting isn't the same as food insecurity, intentional exercise isn't the same as a physically taxing job, conserving energy isn't the same as chronic fatigue. We know that some material stressors can cause chronic, long term damage to people's health. Where do these things diverge? 1 Reply @Viva-Persia @Viva-Persia 1 year ago Much love n respect for Dr Sinclair whose theory on cell information loss driving aging corresponds with universal entropy n disorder which is pushing cosmological age.. also great respect for prof. Yamanaka.. these people are the true rare gems. thank you! Reply @quarantees8736 @quarantees8736 1 year ago Absolutely fantastic. So excited about this! Reply @aussiecfo @aussiecfo 1 year ago Great kickoff! Looking forward to every week. 3 Reply @jojoj3056 @jojoj3056 1 year ago You guys are very funny!!! It’s not Harvard!!! Thanks for this gift of knowledge about reversing the aging process!!! This information is priceless!!! Reply @fx1018 @fx1018 1 year ago (edited) Thank god for this channel..... there is so much BS out there.....especially impressed with David's commitment to giving us facts and clarification. Subscribed! Reply @paprikaveg405 @paprikaveg405 1 year ago Brilliant , I was looking forward to watching this episode and for the ones to come, thank you 😊 1 Reply @AdityaKrishna8 @AdityaKrishna8 1 year ago "Adversity; as long as it doesn't hurt your body, will make you healthy and live long" - David Sinclair 2 Reply @conniehudson4764 @conniehudson4764 1 year ago Subject-matter /Topic is very interesting; thank you for sharing the information in terms that are easy to understand. Thank you for sharing! Reply @prisar @prisar 1 year ago After so much waiting, finally happy to see the first episode came up 3 Reply @chachacha4 @chachacha4 1 year ago I am hoping that this series emphasizes the quality of life, rather than quantity of life. Working with many elders that are in the last decade of their life, it is painfully obvious that the individuals who were athletic throughout their life with a healthy diet have a more fulfilling lifestyle. Too many elders spend their last years in front of the TV, with a Dr. visit comprising the highlight of their week. (True even before Covid shutdowns) There is a social element to a healthy, long, lifespan that cannot be ignored. That said, I enjoyed the content of the first podcast and look forward to the series! 1 Reply @machietheapachie7214 @machietheapachie7214 1 year ago Bought the book and following you zealotly for years. Still waiting for you to address DRY FASTING, mein tutor. Also, as someone trying to build muscle but in a way that pulsates with a longevity regime, I'd love to your thoughts on being in a caloric deficit relative to current weight (I.e.: I've sinned to build the muscle, but now that I have, I can hormetically challenge my body relative to the maintanance demands of my current composition, even if that means eating higher than average aminos seeing as it's for a stronger than average body)? Looking forward to the content 1 Reply @susanwoodley8171 @susanwoodley8171 1 year ago As someone with a parent with a dementia - I’m so very interested in how we can prevent dementia and other age-related decline. For me, I’m less interested in living longer 90 yrs is AOK with me! I’m most interested in living well to the end - upright, mobile, brain intact, no disease. I’m very curious about what you think will finally kill us well into our 100s if we eliminate current common age related illnesses? Reply @Alex-ll4xm @Alex-ll4xm 1 year ago Thank you for doing this podcast! Reply @hydra8734 @hydra8734 1 year ago Sir, you're are a huge inspiration for me<3 Reply @Freed0mOfS0ul @Freed0mOfS0ul 1 year ago James can’t wait ! To apply and teach your messages to others 🙏👍🙏 3 Reply @landonrush7493 @landonrush7493 1 year ago So glad you have your own channel now! This is great! Reply @evilcorp @evilcorp 1 year ago I was struck at 31:02 by how keeping your body 'a little bit afraid' is really helpful. Iit made me think of how bedtime stories for kids in the time of the Brother Grimm or Hans Christian Anderson were characterised by deeply traumatic stories:- Red Riding Hood's grandma gets eaten; the little mermaid dies and turns into foam on the waves (sorry, spoilers), and the little matchstick girl dies surrounded by the glow of loving memory. It's a good metaphor for when you have to tell people about hormesis and autophagy perhaps.[ 1 Reply @raditzaman8022 @raditzaman8022 1 year ago im so excited about your podcast. i been following you since you been to joe rogans podcast back in 2019. i lost my vision that same year. my optic narve has been completely dameged because i drank whisky which was poisoned with methanol. so i was wondering if i could know about your glucoma research and its clinical trial more broadly and whether you considered my kinda problem. please sir leave a reply if you can it took a lot of strugle for me as i cant see. Reply @tred9513 @tred9513 1 year ago Has there been a study of the application of these principals under controled conditions ? Would be interested in reading the paper if there's one out there. 1 Reply @davedave8677 @davedave8677 7 months ago Thanks to you guys and thanks to Huberman who put me on to your work, I have set a goal today which is to live until I'm 150 or more! Yes! Awesome goal or what?! I feel like my lifespan just doubled pretty much! wahoo! Adventure before dementia! Reply @JSiraque @JSiraque 1 year ago I would love for one day to apprentice under Dr. Sinclair, unfortunately that’s not in my Life cards. 3 Reply @desertself @desertself 1 year ago Great that you have your own podcast. How can we submit questions? Kudos! 1 Reply @Articulate99 @Articulate99 1 year ago Always informative, thank you. Reply @RosyRosieRose @RosyRosieRose 1 year ago Dr SInclair, maaaaaaaate! Welcome and thank you!! Love the hour sessions. You're in the gang now that creates supreme content. Praise Jah. Also, you're strengthening my faith in the bible as Adam and Eve were promised they would only die if they ate from "the tree of the knowledge of good and bad" as consequence of an error in their obedience to their amazing Creator that gave them this awesome entire planet to live on with bulk food all over the ground and in the water, free water and energy from the sky, heaps to do, animals to play with, and families to grow. But that wild promise should be able to be proven true, and here you are proving it. Thank you. - Genesis 2:9, 15-25. 1 Reply @markpelayo @markpelayo 1 year ago Super excited for the next 7 episodes! 1 Reply @dr.russellkennedy6330 @dr.russellkennedy6330 1 year ago Interested in how chronic anxiety can advance aging. Is there is anything that is anti aging that would have a benefit in anxiety? Reply @anacron10 @anacron10 1 year ago (edited) Thanks for the great content. Probably missed smtg but I got from your last Huberman podocast you were not using supplements like Atheltic Green in the morning but just resveratrol with yoghurt and olive oil. 4 Reply @enbe5 @enbe5 1 year ago Wow, finally! Nice episode. Really exited for the rest, keep at it 1 Reply @markd6838 @markd6838 11 months ago just listened to this first episode. brilliant stuff, time for the next one now! Reply @realchris3472 @realchris3472 1 year ago Dr. Sinclair, I bought your book and received it just yesterday; I can’t wait to read it. I’ve got a very important question for you: What are your thoughts of David Schmidt’s (Lifewave founder circa 2004) invention of the X39 patch that activates stem cells and provides a more youthful state? Reply @patrick815 @patrick815 1 year ago I have been reading his work for years. I'm so excited for this ! Reply @DocJaeBass @DocJaeBass 1 year ago What's really cool is longevity is first and foremost, a personal decision. Ninety percent of people who learn they will die of their second heart attack if they don't change their lifestyle, DON"T! Yes, they choose to die. Ten percent change and go on to live much longer. It's our choice! I want to hang out with people who are so excited by life they choose to do the work. Reply @halukdurmus2855 @halukdurmus2855 1 year ago love your science and humor :) 3 Reply @chrisr7426 @chrisr7426 1 year ago I was so excited for this podcast. Amazing stuff!!! Reply @robertotrimarchi7363 @robertotrimarchi7363 1 year ago This is really astonishing! May I suggest a name here: Dave Asprey: I was reading his book, Hirtuning, some years ago, and I can find a lot of things here again. I know, he is not a scientist, he is the "bulletproof guy", but he "guessed"/found many things which are parental to these ones and showed that they worked applying them to himself. Reply @cem4724 @cem4724 1 year ago Hi Dr Sinclair! What age should I consider starting to take suplements such as NMN and resveratrol? I'm 26 and I'm interested in starting but I'm worried about starting too early! Reply @boguniab @boguniab 11 months ago Thank You ever so much! Fascinating podcast, hats off!all the best Dr Sinclair Reply @Joe-ug8kg @Joe-ug8kg 1 year ago Hello! I had a question about Metformin and Berberine. Is Berberine a good substitute for Metformin or do they serve totally different functions? Thank you very much. 1 Reply @arupkalita2756 @arupkalita2756 1 year ago This is the podcast, I have been waiting for so long 3 Reply @jamesyorke1949 @jamesyorke1949 1 year ago Co-host Matthew LaPlante keeps David focused. He is very important to this series. Reply @ewcialin85 @ewcialin85 1 year ago Hello Dr David, I have to say excellent podcast 👏 I have got 2 questions: 1. Are you using a sun protection on your face every day? 2. It is possible to reverse in the future for a example a female pattern alopecia by doing your protocols? 1 Reply @AndrewKarczewski @AndrewKarczewski 1 year ago Brilliant first episode. I just wish there was a good way for David Sinclair to be able to recommend supplement brands - without him getting sued etc 1 Reply @Ali-gl8ql @Ali-gl8ql 11 months ago (edited) This is what I was looking for. Great useful knowledges to become younger Reply @ositaozed2252 @ositaozed2252 1 year ago Yo this guy is doing is a big paradigm shift, get this guy a Nobel prize and the funding that goes with it 1 Reply @user-sb9ml1ef4q @user-sb9ml1ef4q 1 year ago Let's make aging treatable disease! 5 Reply @todzilla3926 @todzilla3926 1 year ago Have you seen how ex-differentiation looks in someone with autism? My son has autism and I have been desperately looking for other answers/avenues. Thank you so much for letting me post. Reply @ligiasommers @ligiasommers 1 year ago Amazing episode . Don’t want to miss any!!! 🙏🏻✨🌹 1 Reply @patdelclo @patdelclo 1 year ago Great talk. Loved the book! Reply @carolmcfadden7797 @carolmcfadden7797 1 year ago Hello Hoping this is a platform to be able to ask questions? Thank you so much for entering the world of podcast. The more leading scientists enabling people like me who are unable to decipher science papers, with good information in audio format the better. Huge thanks. Question. 1 What are the effects of fasting on the thyroid? I am reading 'Nutrition for Women' by Ray Peats who writes on page 75 that fasting shrinks the thymus gland. Does research back up this statement, or has the fasting data not included effects on the thyroid? Is there any research that reports negative effects on the thyroid? Question 2 Is there human research on the effects on fasting for woman -sadly for aging( please hurry with the reversal pill) -in the post menapausal phase of life? Looking forward to your next episode on fasting so much. Reply @yamilamolina8669 @yamilamolina8669 3 months ago I can't believe it: las personas con diabetes tipo 2 que toman metformina viven más tiempo que los no diabéticos. Wow es sorprendente, esto cambia el paradigma de la medicina siento que apenas comenzamos a conocer lo increíble del ser humano. 1 Reply @Eduardo-rw8yd @Eduardo-rw8yd 1 year ago I would love a topic on dht and if it is necessary for longevity. 3 Reply 1 reply @fiaflodtrollslanda2484 @fiaflodtrollslanda2484 10 months ago I love this! So awesome! I want to live for at least 150 years. Let's do it! Reply @michelem226 @michelem226 1 year ago I had one of those DNA methylation tests done recently and it came back 5.5 years younger. Thinking about my lifestyle, on the pro side, I've been vegan for 20 years, never partied, and I am a fidgety busy body. On the con side would be high sugar consumption in the past, and I avoid strenuous exercise and extreme weather. 1 Reply 1 reply @Mitchemus67 @Mitchemus67 1 year ago Fantastic and understandable, fills us with hope. Reply @user-js5ly2wx4l @user-js5ly2wx4l 3 months ago So if activating mTOR is bad for longevity, does that mean building too much muscle will accelerate aging? So what is the recommended dose of protein intake in general for longevity? And is there a calculation somewhere for this? And in relation to this, given that waist circumference and body fat levels are optimal, in general, what is the optimal range of BMI for longevity? Just looking at studies and other cultures, being on the lower end of normal healthy BMI range (18.5 to 22/23) seems to be the sweet spot. Reply @vivek9chavan @vivek9chavan 1 year ago Great initiative, David and team🎉✌🏼 1 Reply @zima2252 @zima2252 1 year ago I was waiting for this, thanks David. 3 Reply @28lester @28lester 1 year ago Fascinating podcast. You guys mentioned the common diseases, what about cancer? Reply @lylan8737 @lylan8737 1 year ago Thank you so much. You are give out the most important and beneficial information to masses without any cost. My problem is that when i fast or not eat meat in a day .. mostly when i fast i start to notice that i have sleeping issues. I can’t fall asleep and can’t stay asleep. I really wana fast but due it affecting my sleep negatively i can’t. I’m a women in her late 30s. Can you please address how to cope with this issue. Please. i would really appreciate it 1 Reply @TrangNguyen-tw4ee @TrangNguyen-tw4ee 1 year ago Thank you both for keeping science easy to understand. Found you from Dr. Huberman. Sub! Reply @taykokhuat @taykokhuat 1 year ago I was expecting just one anti-aging product that one can use to prevent aging and one can feel healthy and still looks young as we age even into the 90s. Reply @DavidMedelMacias86 @DavidMedelMacias86 1 year ago Been waiting for this forever! Thank you David! 1 Reply @denny8111 @denny8111 1 year ago Thanks for this important information! 3 Reply @colegno7467 @colegno7467 1 year ago (edited) An interesting article appeared in today’s NY Times that cited a study published in JAMA suggesting that time-restricted eating may have limited benefits (and possible negative effects). The article is titled “A Potential Downside of Intermittent Fasting.” Would love to know what folks think about the article and the studies cited, esp. in the context of the discussions around the topic here and elsewhere. 1 Reply 1 reply @user-mm4rh8wb1s @user-mm4rh8wb1s 1 year ago Hello from Korea! What a pleasant, charming, informative conversation with Dr. Harvard vs Caveman! didn't expect I would laugh listening to this kind of subject. Love this channel. Thank you for the good work. Reply @bendingsnake @bendingsnake 1 year ago Thank you for this wealth of information. 💪🏽 I will try and spread the word. 1 Reply @AP-my7sc @AP-my7sc 2 months ago David, excellent information. How do we know that simply reducing protein instead of fasting isn’t good enough to achieve the same level of longevity gene activation. have they been studies that look at aging with plant-based diet three meals a day versus single meal a day that includes animal proteins versus single meal a day with only plant-based food Reply @josepho5055 @josepho5055 1 year ago (edited) FWIW.......His book is OUTSTANDING. If you like the way he speaks get the audio version it is David Sinclair reading his book{12 hours long] with his co host commenting when a chapter is finished. I have both printed and audio both are well worth the time to read and listen. Reply @TheSheekeyScienceShow @TheSheekeyScienceShow 1 year ago Welcome to Longevity YouTube. This is a nice general overview (but i hope you go into more detail in future episodes!) 3 Reply @dr.mahmoudjarhaman9584 @dr.mahmoudjarhaman9584 1 year ago What an exciting time to be alive ! Thank you scicomm media👏. 2 Reply @lowkaivuan @lowkaivuan 1 year ago The craziest thing is that my grandmother, whose 89, and is rather healthy enough to live on her own, alwayd laments how she was basically forced to go on prolonged fast due to her work, which she attributes to gastric pains, despite me telling her thats not true, she dosent want to believe that she was prolonging her life so much so that she still going strong at such an old age. Reply @olivierboss1 @olivierboss1 1 year ago Hi Dave, hope you are doing well. I like these discussions. Reply @manizhehsarikhani8844 @manizhehsarikhani8844 10 months ago This is an amazing podcast that I have ever heard. Reply @davidneedham6330 @davidneedham6330 1 year ago Great info. Great to see you on here. Million followers in no time I’m sure. Cheers! 1 Reply @robertjleter @robertjleter 1 year ago Question . In a podcast of 8 december 2021 (Lewis Howes)Valter Longo states that 16:8 comes with side effects as gallstones and that skipping breakfast decreases lifespan ..what is your opinion on it 3 Reply @thepathofeudaimonia947 @thepathofeudaimonia947 1 year ago David, could you do a podcast on the science (and practice) of fasting, specifically time-restricted eating and prolonged fasting? Reply @jackgoldman1 @jackgoldman1 1 year ago (edited) My father in law never aged with disease, his hearing did fail, but he just faded away, dying at age 95. Never a disease, heart attack, stroke, cancer, nothing, ever. He just faded away, aging, dying, at age 95. FEW men live past age 95. Living well gives people a last ten years of better life. We all still die. Death is our last doctor and he cures all our ailments and diseases. Rest in peace. 1 Reply @susanstultzhauss132 @susanstultzhauss132 1 year ago Fabulous!!! Hopefully expectant of the coming episodes! Thank you so much!!! 1 Reply @TheCookiecupcakes @TheCookiecupcakes 1 month ago Thank you for this information. Very valuable. Reply @Lianne-issa @Lianne-issa 1 year ago A very interesting podcast… sounds like I’m doing the right things re fasting, exercise and diet… I’m very much in favour of making natural lifestyle choices that increase longevity You’re making me feel a little on edgy talking about reversing ageing through scientific meddling. Although we would all (selfishly) love this technology for ourselves…. What happens when the world keeps feeling with new souls but the old ones aren’t exiting? It may sound crass but the world is barely coping with 8 billion people. If this technology became widespread it would create huge sustainability issues. I think it would be like opening Pandora’s box…. I can’t believe more people aren’t challenging this in the comments…. I’m going to watch the rest of the series and see if this is discussed. Reply @aikaai @aikaai 1 year ago This is going to be fun, these next seven episodes. 3 Reply @krmotkowicz @krmotkowicz 1 year ago heard 2 minutes and pressed like, wish there was "love", "incredible" or "groundbraking" button. Ok, let's do 1 more hour of active listiening !!! David - your work and devotion to the area is beyond any scale. Reply @rosalinabird @rosalinabird 1 year ago I observed that when I was in primary care. When Alzheimer sets in, their blood pressure improves and other little problems are minimized. 1 Reply @snowwhite8143 @snowwhite8143 1 year ago (edited) OH MY GOD I CANT BELIEVE IT (I do) this is amazing. I love science. Thank you so much for this. Omg, I’m glad to exist in the 21st century. Reply @jeremywebster8815 @jeremywebster8815 1 year ago It was the best of times it was the worst of times . . . Thanks for bringing the best guys!!! 1 Reply @jant_ @jant_ 1 year ago Is there any research on the effectiveness of stacking different methods and substances on the reduction of aging? Like doing time restricted eating to reduce mTOR activity and taking an mTOR inhibitor like reaveritrol together. I guess at some point you will get diminishing returns. Same goes for using metformin in contrast to just excercising after every meal to reduce blood sugar. Does this stack or is excercising alone enough to reap the same benefits than taking metformin? 1 Reply @Freed0mOfS0ul @Freed0mOfS0ul 1 year ago I looked up SIR2 , it says "longevity protein Sir2 is an NAD-dependent histone deacetylase" so more NAD turns on SIR2 ? for longevity and anti-aging ? 3 Reply @denisegaliano6724 @denisegaliano6724 1 year ago I CANNOT WAIT FOR THR REST!! Ibe listened to you so much and been wanting you to do this for so long. Thank you. Thank you. Thank you Reply @stavroshalvatzis2947 @stavroshalvatzis2947 1 year ago Brilliant. Thank you, David. 1 Reply @explorersoftheworld1193 @explorersoftheworld1193 1 year ago thank you for very valuable and useful knowledge, I would be interested in the topic of fertility in women, how to care for it and whether it can be kept Reply @eszter177 @eszter177 1 year ago Excellent. I appreciated Matthew LaPente's narration as well. Reply @quarantees8736 @quarantees8736 1 year ago David, under exercising & over eating are a brain and body disorder similar to other disorders like depression. The solution is I believe neural treatments. This is a very important piece of improved healthspan. Let me explain: A relative has a lifelong aversion to exercise. They have never felt feel good endorphins - actually the opposite - they always feel worse after any exercise. They have never felt motivation to exercise (I believe the Ventral Tegmental Area controls motivation to move). As a result of decades of this disincentive to move they are now immobile and soon to be wheelchair bound. A double whammy is they have no ‘brake’ on eating & would be called a food addict. Food gives them much stronger euphoria than I believe average people experience. I believe the brain region for compulsive over eating is the AGR, plus disorder of Leptin (the brake) and I forget the chemical accelerator. Given 30% of population are overweight, I think about 30% of people have one or both of the brain and body disorders described above. We are seeing the beginning of treating this at the neural source via Saxandra & GRP-1, but medicine is very behind in treating the actual source of under exercising & over eating. It’d be great to hear you & your colleagues thoughts on this. Thanks! Reply @GeorgeKottakis @GeorgeKottakis 1 year ago I was here when humanity changed. 6 Reply 1 reply @69JonnyP @69JonnyP 1 year ago (edited) 1st ep’. Very interesting and well presented information of what might be possible before too long regarding human ageing & health. The disappointment came from no mention (as yet) of possibly the most important impact of extending human life. Population growth is already stretching the earths resources so how does society cope with more strain on economy, ecology, food, housing, all the things people need for a sustainable life. This drive to extend one’s life seems far from the reach of the majority who still struggle to get enough food, clean water & safe shelter. All I heard so far is the potential to extend one’s life dramatically but it will be available for the privileged few not those living payday to payday. Basically the story portrayed in most science fiction stories of how humanity ends up. So hopefully ep2 will get into the ethical issues of extending our lifespan before endorsing supplements beyond the means of most. 🤞 1 Reply @sdm21 @sdm21 1 year ago I'm feeling healthier just listening to this conversation. Reply @kevinkroll1824 @kevinkroll1824 1 year ago (edited) Super pumped about this podcast! Reply @spowar4895 @spowar4895 1 year ago Thanks for the video, excellent. Would it be possible to know which biotracker is best in the UK because the inside tracker doesn't provide DNA support here? Reply @raiderlife4478 @raiderlife4478 1 year ago Thank you guys so much you and Dr huberman, your changing lives. 1 Reply @ShervinShares @ShervinShares 1 year ago 22:28 how can one build muscle AND increase Lifespan? I want big muscles, but also don't want to die early 3 Reply 1 reply @digitalambience6993 @digitalambience6993 1 year ago RadioLab podcast has an episode (The Dirty Drug and the Ice Cream Tub) on how Rapamycin was discovered and how it almost vanished from our knowledge, but for one man’s love for the molecule. It’s SO good. 1 Reply @drpriyankamehta @drpriyankamehta 1 year ago This is inspiring as there is a science to reverse aging and healthy lifespan or heathspan 1 Reply @zenorabariella4359 @zenorabariella4359 1 year ago I'm looking forward to hearing your take on collagen supplements. It seems like they would not promote low mTORs. 2 Reply 1 reply @lynnnestor7985 @lynnnestor7985 1 year ago Brilliant, brilliant, brilliant👌 ty for today David and in advance for the next 7 episodes. 1 Reply @angel_daze @angel_daze 1 year ago Have been looking forward to this thank you Dr. Sinclair! 2 Reply @youtubeiscruel3946 @youtubeiscruel3946 1 year ago Didnt the metformin for reversal of human aging study have no control group? I didnt read the study because it is confusing but heard that from a dr. 3 Reply 2 replies @jayparmar7859 @jayparmar7859 1 year ago He doesn't even look in his 30s. Wow... Man what a gem of knowledge he hos giving here. 1 Reply @ovidiuc4 @ovidiuc4 1 year ago In future episodes, can you please add numbers to accompany statements like "live longer"? For instance for people on metformin. They live longer, but by how much? 0.5%? 20%? Thanks for sharing this information and making the research. Reply @benjoseph6723 @benjoseph6723 1 year ago Thanks for sharing your knowledge with us 2 Reply @evanbarnett6034 @evanbarnett6034 1 year ago Why only 8 episodes? Should be 800. This is good stuff! Reply @ineskhaz1203 @ineskhaz1203 1 year ago Hi I hope you can have an Arabic subtitle to your videos..this translation would help a lot of us who I’m sure very interested in your studies and research. Thanks and good luck Reply @user-rf7rb3ok6j @user-rf7rb3ok6j 1 year ago Hello from Athens, Greece great info however this podcast does not feel like an actual podcast the conversations seem to be strongly guided by some sort of script. feels like an audio-book with lots of info but with video 4 Reply @thepathofeudaimonia947 @thepathofeudaimonia947 1 year ago One question about taking Metformin: at what age does one best start with the medication? Should one start as young (as an adult) as possible, or there a point when it becomes beneficial (eg. at 40 years of age)? Reply @tanchengfai @tanchengfai 1 year ago I’ve been following this guy here for years. Not aged 1 bit. He actually looks younger. 🙂 Reply @michaelbrister7714 @michaelbrister7714 1 year ago Low energy = longevity. Reminds me of colder molecules moving less quickly and time slowing down near the speed of light. Just slowing down the reactions in a sense, not necessarily getting more of them. I’d say age is relative as well Reply @garlicbreathandfarts @garlicbreathandfarts 1 year ago Since I eat properly and swim in the sea everyday, aging has stopped for me. I am actually getting younger. People hate me for it for some reason. 1 Reply @gottiesgorrillas4137 @gottiesgorrillas4137 1 year ago Thank you for this podcast. Reply @drewmccu258 @drewmccu258 1 year ago The Athletic Greens advertisement plays like a hostage statement 4 Reply @afifaimran6450 @afifaimran6450 1 year ago Oh my godddd I’ve been looking for your podcasts!!!! At last!!!! You and Andrew huberman are just a blessing ❤️❤️ Reply @koshtigir3437 @koshtigir3437 1 year ago Dear professor Sinclair, could you describe how does sex affects the aging process? Thank you and congratulations to this helpful and informative pad-cost. With best regards Ben from Germany Reply 1 reply @CalmLisa @CalmLisa 1 year ago I’m exhausted by life. I just want to get to the finish line and die of “natural causes” like Betty White, and not be a drain on my family. Quality of life is important to me but in this current world, quantity is less so. I’m not ready to check out yet though so I appreciate your knowledge and your desire to keep the rest of us in the loop. I’ll continue to tune in. Looking forward to future episodes 👍 2 Reply 1 reply @BobMacNeal @BobMacNeal 1 year ago The audio version of Lifespan is an informative and interesting listen. 2 Reply @pubz2149 @pubz2149 1 year ago I have been following Dr. Sinclair since I was 25. I am 22 now. Reply @stevenj6421 @stevenj6421 1 year ago FINALLY! 4 Reply @stephenkobani334 @stephenkobani334 1 year ago We in Nigeria love what David Sinclair is fishing to world in terms of Longevity .visa vis Healthspan and Lifespan but we are limited because the Products aren't available in West Africa. 1 Reply 1 reply @jawadkarim6615 @jawadkarim6615 1 year ago Its the number one Wonder of the World.. any of other wonders not 2nd, not 3rd, not 4th... even far behind compare to it.. Great Job Professor dr. David Sinclair... 1 Reply @poopslappa1661 @poopslappa1661 1 year ago I laughed outloud like a villain thinking about being immortal. I'm hyped to learn how (: Reply @alisturkericmacnanty159 @alisturkericmacnanty159 1 year ago You guys have just become my new gurus. Reply @claudiafernandez3548 @claudiafernandez3548 1 year ago Amazing, thank you Dr Sinclair! 2 Reply @joannsmith3589 @joannsmith3589 2 months ago why did the series stop? it was so informative Reply @freedomwarrior5241 @freedomwarrior5241 1 year ago Thank you for this information! Fascinating! Reply @mrala @mrala 1 year ago next episode is about fasting and diet; epic; would you include a section about how to do both bodybuilding ( as much as possible ) and reverse aging at the same time. how to have best of both worlds, and how one affect another so we can personilize for our goals ;) Thank you 1 Reply @thaile9751 @thaile9751 1 year ago Thank you Dr. Sinclair. What kind of supplements should I take to help me to substitute the bile? Since the doctor removed my gallbladder. I know the presence of gallbladder is very beneficial. Any help please. Reply @gabrielcabello9487 @gabrielcabello9487 1 year ago I’d like to say I’ll be listening to your advice. Thank you! 1 Reply @nickdmo7637 @nickdmo7637 1 year ago Hello, I have watched many of your videos and have really had my interest peaked. I'm curious,do you know or know where I can find out if the NMN will interact in a bad way with my Warfarin? After all I've watched, I am considering taking the NMN, TMG, Ca AKG, and the berberine. To b clear, I'm not asking for medical advice, I would never do that, but I can't find any information about this at all. 1 Reply @cholakicha @cholakicha 1 year ago Just when I think there is no more time in the week for more podcasts ... 1 Reply @NinjaofApathy @NinjaofApathy 1 year ago I'm here from Huberman. I really hope in the future of this podcast we have the opportunity to throw out a few questions to inspire some discussions from yourself. 2 Reply @meathead365 @meathead365 2 weeks ago For those of us on a plant free diet, maybe give the greens a miss, also the glucose monitor Reply @monhut6124 @monhut6124 1 year ago Greetings from Prague, Dr. Sinclair! So excited about your channel! I can’t believe my dream has come true! 1 Reply @MultiGlobalnews @MultiGlobalnews 1 year ago I won’t have to wait a 100 years I can tell now that this is the one podcast the very moment in earths history that has changed the course of mankind for all eternity 1 Reply @viviancastro2783 @viviancastro2783 1 year ago I have become a crusader. I share and then I share and share again and again. And will continue to do so. I am 60 years old, suffer from fibromyalgia and was told by my doctor I would end up disable. I totally refused to accept that and trusting God I changed my habits and came across to you through my 25 ur old niece. My brother has Parkinson’s, my cousin has MS, my mom had ALS. I started taking NR and Resveratrol and will start on NMN soon. I used to struggle to wake up. Now I wake up happy and eager to work out. I now run 25-30 minutes. If someone told me I would run I would have bet some money I would never be able to do that. Thank you thank you thank you to the Nth power. Reply @chinmoydhole1794 @chinmoydhole1794 1 year ago Dr Sinclair, can you comment on eating fruits every day. For example, if one eats ~ 1kg fruit per day to control his hunger, will that be justified if his target is to attain longer lifespan ? Having too much fruit is good with total stop in refined sugar intake otherwise ? Thanks 1 Reply @bekithomson5200 @bekithomson5200 1 year ago (edited) If your doctor runs a panel for you (such as, part of your annual exam) you should get the data points offered in the INNERAGE 2.0 package. What is the impact of metformin on mitochondria? 1 Reply @Edaryion @Edaryion 1 year ago Thank you for making this! Reply @robertsegovia4663 @robertsegovia4663 1 year ago Thanks to you and your colleagues for their extraordinary curiosity. I hang on your every word. Thanks Reply @JEERO392 @JEERO392 1 year ago I am starting to like all this stuff in just one episode. Reply @aminshobeiri1037 @aminshobeiri1037 1 year ago The more the human lifespan is extended, the higher risk threatens the health of the teeth at later stages of life. Teeth just happen to grow only once in their mature, permanent state but they never recover from any sort of damage, which makes them a crucial yet unrenewable pillar of human's general health. However, these dental problems are not necessarily aging-driven. I am really curious to know if aging studies might usher a new avenue in dental health by any means. If we are very optimistic that humans are to live longer in the future, this is a legit concern. 1 Reply @JP-qn4uo @JP-qn4uo 1 year ago What are Dr Sinclair's thoughts on the testosterone-lowering effects of testosterone? 1 Reply @kenczech9371 @kenczech9371 1 year ago Cheers to you! Long live an optimized life! 2 Reply @HumanLABPodcast @HumanLABPodcast 1 year ago Can't wait to see more! :) Reply @ShervinShares @ShervinShares 1 year ago I'm in my 20s and Dr Sinclair still looks younger than me... 2 Reply @AmatriceBand @AmatriceBand 1 year ago Looking forward to episode 2 2 Reply @geraldtong4414 @geraldtong4414 1 year ago Hi Dr Sinclair, what age ranges is the best to receive the suites of age reversal treatment? Reply @juliejoshua9880 @juliejoshua9880 1 year ago Wow 👏 👌 What a revelation. God bless 🙌 abundantly and sustain you. This is a major breakthroughs. Please be putting texts in the video to elaborate cox medical terms are difficult. I want to be your student. 1 Reply @alinsolomon @alinsolomon 3 months ago Back after 1 Year, hopefully with a season 2 in The near future. Would like to know on how can we can improve heart desieses in the future, like artherosclerosis, and clogs. Or if there is a Way that by reversing biological age to also improve the coronary arthery diseases, and reversing The calcium score? Reply @shaunigothictv1003 @shaunigothictv1003 1 year ago Excellent interview. 2 Reply @angkr8579 @angkr8579 1 year ago This is beyond intersting! Thank you!! Reply @lihamedi8363 @lihamedi8363 1 year ago having three or more versus two children is related to worse late-life cognition. They also found that this effect is similar for both men and women. Fertility may affect late-life cognition via several pathways. First, having an additional child often incurs considerable financial costs, reduces family income and increases the likelihood of falling below the poverty line, thus decreasing the standard of living for all family members and possibly causing financial worries and uncertainties, which could contribute to cognitive deterioration. Reply @the_0_man @the_0_man 1 year ago What if we genetically modify non conscious living things and make possible a symbiotic relationship like we have in mitochondria and cell? Can this be achieved? Reply @idali6144 @idali6144 4 months ago (edited) Fast, reduce glucose and proteins, stay cool, get exercise. Sounds like a climbing expedition high in the mountains, really loved the idea. Does breathing low oxygen levels counts as well? Reply @kevindelasoie1503 @kevindelasoie1503 1 year ago (edited) I'm so fascinated but also I have many questions and fears. What will happen in a world with much more longevity, we need to reshape our society, and how do we deal with overpopulation? 2 Reply 1 reply @axeldaguerre8838 @axeldaguerre8838 1 year ago I doubted about Laplante going to be of any value at the beginning, I was wrong I love that his questions was to doubt a statement and waiting to be answered by Sinclair, he asks questions we want to ask. 1 Reply @dillonblack4524 @dillonblack4524 1 year ago This channel is going to grow so fast 1 Reply @subbhadipghosh474 @subbhadipghosh474 1 year ago Thanks for this vast information.. Hope new podcast will be more interesting.. Reply @teganchappell8501 @teganchappell8501 8 months ago Dr Sinclair- I am grateful for your information over the years. I’m wondering why you wrote to the FDA about nmn? Reply @rickyu1978 @rickyu1978 1 year ago Really like Dr Sinclair, been introduced to him via JRE. Reply @16meckls @16meckls 1 year ago Not a scientific study, but my mother in-law indirectly followed this recommended lifestyle: low red meat consumption, more vegetables in diet, fasting and exercise. The one difference is that she drank alcohol more frequently than recommended. She was always worried about her appearance so she exercised, ate less often and wasn’t a big meat eater; more salads and fish. She is in her late 70s with dementia. Is alcohol that large of a factor? Reply @peterkowalchuk850 @peterkowalchuk850 1 year ago David. Can you please speak about cannabis and longevity in this series? I am much more present, motivated, and heathy when I use cannabis regularly as a mood stabilizer but I don’t want to use it at a risk to my longevity. Is there a way to ingest it safely and still have an extended lifespan? 1 Reply @SeanMurphy15 @SeanMurphy15 1 year ago would it be possible to create a full human simulation that we can tinker with using ai to find out what would improve longevity the most? 1 Reply @garethzbarker @garethzbarker 1 year ago Awesome. Thanks Dr. Sinclair. Reply @joncollins387 @joncollins387 1 year ago Great podcast. Thanks. Unfortunate that Levels is restricted to the US. What's the work around? Reply @1DemocraticMatch @1DemocraticMatch 1 year ago (edited) David - PLEASE hurry - there is an aging Angel sent from heaven to save the planet who needs your technology now. Dame Julie Andrews, Mary Poppins to most, Maria Von Trapp to others... she has spread more love, joy and compassion in this world than any other person who ever lived to my mind... to see her young again would make my heart explode with joy... a death I would gladly suffer if you could but make Julie Andrews young again 2 Reply @pablog9041 @pablog9041 1 year ago Excelente contenido. Reply @rajumohan1 @rajumohan1 1 year ago one of the best speakers I have heard and I am hoping David can soon find a way to make my optic nerves stronger and mybe bring vision to the eyes after rd 1 Reply @plamencho111 @plamencho111 1 year ago Good luck with the new podcast! We love you! Reply @AEaK37 @AEaK37 1 year ago I appreciate you starting a podcast 1 Reply @ajean81 @ajean81 1 year ago Please discuss more on how you "pulse" supplements. Duration taking, duration rest. Is the pulse routine vary based on the supplements? Thanks in advance. Reply @___Truth___ @___Truth___ 1 year ago OMG Mr. Sinclair, I'm so excited for this podcast. LETS GOO 2 Reply @neilavery2632 @neilavery2632 1 year ago Mind blown! Thank you!! Reply @franconero585 @franconero585 1 year ago Hello!! I'm sending you all the best from Romania! Thank you for infusing hope and science! Reply @gkarpagam @gkarpagam 1 year ago Oh gosh ! David's Sinclair's own channel. It's like a dream come true. No more listening to others talking about "David Sinclair said that / David Sinclair did this " :D 1 Reply @flowercoffeeL @flowercoffeeL 1 year ago Can anyone share what Sinclair thinks about blood pressure and aging? Reply @KenfuPanda @KenfuPanda 1 year ago Levels not available in Hawaii 😢 but love the work you’re doing !! Thanks 🙏 Reply @mushtaqbhat1895 @mushtaqbhat1895 1 year ago Finally an unexpected Sinclair YouTube Channel! Almost all, especially Americans, on the Social Media Health Scene are quite comfortable convincingly advertising the products of their sponsors often without doubt out of a morally laudable personal belief and the need to cover increasing costs and time dedicated to such services. However I do find their professionalism sometimes a bit disconcerting; probably because I am not an American and culturally always wary of showmanship professionalism especially of snake-oil type. You David seem to be a bit lost here and apparently needed the prodding from your companion. Uncomfortable and apparently forced and without much heart into it. Your unprofessional rendering really won my respect! It is really not your world. You are a scientist and a humanist par excellence first! Wish you lot of success in all of your endeavor as it truly seems to be dedicated to us all! BTW quite a lot of your work has already influenced the structure of the debate, some terminology has firmly established itself within the standard vocabulary of many languages as it has spawned a lot of new cottage and big time industry. But most important of all you are giving the much needed autonomy in decision making to the people themselves. The potential to take their health into the own hands before it becomes an issue for the medical and pharmaceutical industry! Unlike the multitudes of trendy Hypes that we are constantly bombarded with that come and go, yours is an entirely new different class and will most probably become a part of general health practice in future. Hats off young man! And here is Bob Dylan for you: May you forever remain young! 1 Reply @drcolmunirahmed9065 @drcolmunirahmed9065 1 year ago Wonderful, great advancement in one's effort to live longer scientifically,not realising ppl taking lesser simple food keeping one third of stomach empty as sunhat rasool pbuh doing more work/exercises n keeping fast as directed in Islamic teaching 1 Reply @godlikenovauniverse1118 @godlikenovauniverse1118 1 year ago Love this content the mystery can we regenerate in time or DNA repair possible can we humans unlock the secret Reply @AlbertKingboss @AlbertKingboss 1 year ago The intro has a strong Lex Fridman vibe. Great work! 1 Reply @VORP125 @VORP125 1 year ago This is fantastic! 1 Reply @aloevera7422 @aloevera7422 1 year ago 49:03 “I know of people that have reversed their epigenetic clock by twenty years over a year.” — David Sinclair Reply @charlesschulze8173 @charlesschulze8173 1 year ago As you mentioned on other podcasts , there is so much information out there that many of who would like to change our trajectory of aging are left with no clear path. I scoured the internet for those products you recomed, and use yourself, only to find that they are not unique, in fact, everyone wants to sell these products. I want to follow these protocols, but I do not want to waste my money. How do i navigate through all this and find what I need. With much respect Thank you Reply @whittlejoe @whittlejoe 1 year ago Do you have an opinion on seed oils causing excessive levels of linoleic acid, thus fueling chronic disease? 2 Reply @franciscojmercado8538 @franciscojmercado8538 1 year ago (edited) I read the book a couple of years ago and it changed my life. I started meditation, intermittent fasting and keto. Stopped drinking completely and made a bunch of other lifestyle changes. I truly feel like I'm 20 years younger than I am. I climb and it's definitely reflected in my climbing. I can do stuff that kids in their early 20's who have been climbing longer than I have can't do. 2 Reply @dikeledimogobe5117 @dikeledimogobe5117 1 year ago (edited) David Sinclair, the man I so much adore! I so much respect! Greetings from Africa! Reply @VRCM_Skywarn_XUSA @VRCM_Skywarn_XUSA 9 months ago (edited) Metformin alternatives: Inositol, Berberine, N-acetyl-cysteine, Cinnamon, Curcumin. (Curry/Mustard) - Cinnamon/pumpkin spice. It's my favorite. 💪🎃 - I reversed engineered most of the precursors. Its all flavenoid plant based... Most of these are very commonly used spices and oils, that I use every day. I go to my local coffee shop and take my daily dose of metformin. Cinnamon pumpkin spice, coffee. Berberine is a type of licorice flavoring powder, from a grapevine. - Anything, that's got spice, flavor or bitter with citrus works. 🌿🍋🍵 Reply @rabbitnpop7034 @rabbitnpop7034 1 year ago Simply wonderful !! Reply @holliedeaver4258 @holliedeaver4258 1 year ago (edited) Love this! Thanks to you and others for free public education I trust and will use and BLOCK all other noise... (Dr Andrew Huberman, Dr Peter Attia as the others I trust) 1 Reply @moonjeeworld @moonjeeworld 1 year ago I am delighted to learn about your research on human immortality, the ultimate goal. Of all the research you have done, would you please many women's "missed chance having a baby when they were reproductive years? Can you do some research if women's "missed time" can be reverted. Can women of old age, very healthy people, can have their reproductive years restored? Mostly professional women who missed having children can have a baby with their dream man- of course, a much younger man. Reply @martashea159 @martashea159 1 year ago Thank you for all this information! One thing I don't understand, is why then people on carnivore diets or keto look so good? They seem to have less wrinkles and better muscle tone. 1 Reply @jadevillaflores9542 @jadevillaflores9542 1 year ago Many thanks Dr. David.. 🙏🙏🙏 Reply @caliskanutkan @caliskanutkan 1 year ago The mad scientist of our time! Reply @bwmartin24 @bwmartin24 1 year ago (edited) It's funny that during the disclaimer Dr. Sinclair emphasizes that mice studies cannot be extrapolated to human studies and that they are very different, only to then talk about our close similarity to a banana or a tree. (To be clear this podcast is amazing, though!) 1 Reply @faceeverychallenge @faceeverychallenge 1 year ago (edited) So let’s say someone is training to put on muscle. Is that bad? Can short periods after resistance training of increased mTor be beneficial? Can someone strive to gain more muscle but also increase longevity? Reply @dollyvandenbrink5211 @dollyvandenbrink5211 1 year ago Thanks David keep up Helping Humanity. Reply @wisalabughalia555 @wisalabughalia555 1 year ago This is absolutely exciting! 1 Reply @lynnstine6241 @lynnstine6241 1 year ago By the way... love the podcast! Now I don't have to go search for you on other podcasts. 1 Reply @tessacyclone6329 @tessacyclone6329 1 year ago Can you please add other languages to the captions to these videos . Please in Spanish italian French Arabic Hindi Russian Portuguese. I know so many people who will benefit if this is easier to understand in their home langauges . Many people are diabetic and some i know have health and death related anxiety from their illness and deserve to know thr metformin they are taking , is as far as I am able to understand , helping to work like fasting in that it turns on AMPK and will prevent x differentiatiation in their cells . Reply @elensayista8988 @elensayista8988 1 year ago This is giving me vibes of the Robert Sapolsky all time classic "Biology of Human Behavior" Stanford series 1 Reply 1 reply @MarkOlsen661 @MarkOlsen661 1 year ago Many thanks David....greatly appreciated Reply @cashglobe @cashglobe 1 year ago That intro seems quite similar to a great scientific podcast I’ve seen before 🤔 hehe, just kidding. Very excited for your show, Professor! Will be tuning in. Reply @shashibajpai8644 @shashibajpai8644 1 year ago Love this...quite interesting ..It will change the world... 👍 1 Reply @lckee820 @lckee820 9 months ago I just found David Sinclair and I’m rather lazy. Esp where excercise is concerned. Somehow through diet (I eat small portions 3 hourly) and supplements like Metformin, Melatonin, various vitamins etc my 17 year old grandniece thought that I was 17 years YOUNGER than her grandfather. He’s 77.5 and I’m 79.5 years old!!! 1 Reply @step7286 @step7286 1 year ago I love the intro because it is similar to dr andrew's hubermanlab. This conversation was gold. Reply @postproduction2339 @postproduction2339 1 year ago (edited) Thanks for the vids David, always nice to hear you talk about these topics. Fyi, there's no need for the dummification by the guy in the glasses, it kind of makes everything much more difficult to follow when he interupts you and slows down your train of thought since you explain and illustrate very well on your own. He kind of confuses everything after you expressed it very clearly and concise, just keep talking the way you always do, everyone will understand. Reply @conniehudson4764 @conniehudson4764 1 year ago Tuned-in based on hearing your interview with Dr. Andrew Huberman (Professor of Neurobiology and Ophthalmology at Stanford. (That’s right - I’m #hookedonhuberman) Comment, Observation/Opinion, Question. 1) Subject-matter /Topic is very interesting; thank you for sharing the information in terms that are easy to understand. 2) Conceptually I like the format (cohost who is pretending to anticipate questions that your listeners may have). It was actually helpful, “but” he was taking up too much space in my opinion. I like him, but this is your show and it was too much him. (My opinion only). 3) When protocols for extending lifespan without physiological or cognitive compromise are perfected, space travel may become more feasible for humans. Have you spoken with Lex Fridman, Elon Musk (or others) about this? Thanks again David. Subscribed and looking forward to the series. Reply @jansogge7335 @jansogge7335 1 year ago Taking care of my husband who has poor health/dementia due to poor health/living choices. Taking its toll of me no matter how i try to not let it. Reply @robertmaxwell611 @robertmaxwell611 1 year ago Looking forward to this series Reply @mauriciobrenes8511 @mauriciobrenes8511 1 month ago It is incredible that we can access this information for free Reply @captainjeffproductions3301 @captainjeffproductions3301 1 year ago Good info Dr Sinclair. Just one question. With all the Benfits of fasting, why do you have yogurt in the morning just to take vitamins (technically breaking your fast with the yogurt) Why not just hold off and take those pills later with your first meal? Reply @Kindnessambassador @Kindnessambassador 8 months ago he is amazing - and he first person to talk about the negative impact of over iron on aging. Trying to connect him with Dr Xi Huang, a global expert on this topic and founder of groundbreaking new technology that combats the effect that excess iron has on the signs of skin aging! Reply @cketheridge2643 @cketheridge2643 1 year ago Can't wait for the next episode! Reply @andrewmikhail7142 @andrewmikhail7142 1 year ago £44.99 What would be the chance of David emailing me to discuss being part of a trial for him in the Uk I’ve been through hell and back with covid and had a second chance in life I’ve and I’m determined to change for my wife and kids. I’ve listened to plenty of his podcasts and interviews and before I buy certain things I’d like his advice, I’m happy to pay whatever for his time I just need his help and be confident doing it. I won’t bother him or his team daily I just need guidance. 1 Reply @Alan13 @Alan13 10 months ago Dr. My dog is 16 age (8kg) who is suffering from heart diseases, she is taking medications for maintenance but don’t see much improvement. Do you think I could give her NMN to try, but she is already 16, do you think it may help ? Reply @quantumflux000 @quantumflux000 11 months ago ♥♥♥ just awesome! very nice pace to follow along as a non-scientist Reply @gloria6396 @gloria6396 1 year ago U R THE REASON Y I CAN THINK MY IMAGINATION ABOUT EVOLUTION IS NOT CREAZY THANK U THANK U THANK U I HAVE BEEN FOLLOWED U FOR YEARS BUT THIS MAKES ME FEEL A LOT MORE IN TUNE WITH YOUR RESEARCH 1 Reply @bambooinchina @bambooinchina 10 months ago Just chatting with my sister who is diabetic ( type 2) & takes Metformin. She said shes had kidney problems, while on it. How safe is it? Reply @zlizlihorde2545 @zlizlihorde2545 1 year ago Amazing, I was waiting for your personal channel last 3years, exiting times indeed ! Reply @jagdishkshatriya3009 @jagdishkshatriya3009 1 year ago great .......easy to understand for a common man . Reply @luisrodrigueziii7316 @luisrodrigueziii7316 1 year ago Think of having Dr. Matthew Walker on the podcast? What an amazing conversation that would be. Reply @harveyjones1 @harveyjones1 1 year ago looking at the background to where this was filmed it appears Mr Sinclair and his team can also time travel back to 18th century France 1 Reply @skl9968 @skl9968 1 year ago Wish someone can translate this to all languages. Reply @jenniferjenful @jenniferjenful 1 year ago What are your thoughts on hormone replacement therapy? don't added hormones shorten life? Reply @yayangtapir4130 @yayangtapir4130 1 year ago I'm literally jumping off my chair.! This is power pack. Finally a "guardian angel" to safe us.😊 1 Reply @lynnstine6241 @lynnstine6241 1 year ago I'm a bit unclear. Is it better try to activate AMPK, or is there a downside to this? 1 Reply @husamalfaouri2070 @husamalfaouri2070 1 year ago i hope you will cover what poor people can do while they can't afford buying supplements, in other word , what is the best anti-ageing guide without supplements ? 2 Reply @bigggtime6336 @bigggtime6336 1 year ago super engaging conversation, nice! 1 Reply @reevez @reevez 1 year ago Dear Dr Sinclair, in your podcast with Huberman you mentioned the western diet as unhealthy in reference to its high fat content. There is a debate in, let’s call them science-inspired YouTube channels, that claim that vegetable oils are what’s actually bad for us due to the way they are produced, while fat from animal sources is supposedly much better for us, as it’s more in line with what our ancestors would have eaten. Could you comment on that? Should we rather be cooking with ghee, for example, than with vegetable oils? 1 Reply @keithrichard391 @keithrichard391 1 year ago Even if we make it to 1000 years old--we will still meet Our Maker:) Reply @edgarmartinez3946 @edgarmartinez3946 1 year ago I like the content 🙌 Just a little odd that the sponsorship script is pretty much the Huberman podcast script ... same goes for the opening scenes. Kinda feels like spinoff podcast. Not bad, just an interesting thing that was explicitly apparent. Reply @Alex-hu8gj @Alex-hu8gj 1 year ago Everything is possible with enough resources :) Don't stop ever whatever the reason. 1 Reply @JP-qn4uo @JP-qn4uo 1 year ago Great talk! Reply @cheryld6920 @cheryld6920 1 year ago As an add on to my below comment, good health is for the wealthy. If I wanted to truly follow all the great advice I'd have no chance. I have a glucose tester because it was on special offer. I can't afford to buy organic non pesticide food. I can afford some supplements but most definitely not most of the recommendations. It's so unfair in life that there are so many of us who in reality have more chance off illness just due to our finances. 1 Reply @toufisaliba2806 @toufisaliba2806 1 year ago Watch this in 2022 thinking David Sinclair is 78 years old.. In 26 years, he may look even younger, most importantly he will be 78 and you won't be surprised. 1 Reply @dave59321 @dave59321 1 year ago love the info, i recommend in editing add pictures of the various things you discuss. animals, trees, etc. Reply @Valkiirija @Valkiirija 1 year ago Aww, may be the Force and strength of the Great Grail with one who explains the mighty Science with analogies like cassette tape. Seriously, I love those people heartedly and my gratitude levels are just like overall DNA length: to the Moon and back, eight times. This is the Way. 1 Reply @mirusvet @mirusvet 1 year ago Thank you!! Waiting for Biological Clock Test! All the best! 1 Reply @carlafarrace6779 @carlafarrace6779 1 year ago Dr. Sinclair, I am interested in studying molecular biology. Where do I begin? Thank you. Reply @justinberling4946 @justinberling4946 1 year ago This is going to be incredible 1 Reply @sevinlindsay7323 @sevinlindsay7323 1 year ago There is nothing more exciting than this; for you, me and the world. Reply @rreynomom1 @rreynomom1 1 year ago Looking forward to listening! Reply @anderswallin3883 @anderswallin3883 1 year ago (edited) Hello David. I don't know if you will see this comment but i have a few questions for you. I just started fasting and skipping breakfast and this is my fourth day doing so, and i am doing fine so far. I enjoy candy and sodas, pizza and hamburgers. I do know that these are bad for me but i don't know if can ever quit eating such things completely, but i do try to limit the amount i eat. I also have IBS and the IBS experts say that there are things that i should not eat, like apples and onions and a whole bunch of stuff to keep my stomach working. So here is my first question: Can i enjoy a pizza, some soda and candy or cockies on a saturday and follow your teachings the rest of the week and still live a long and healthy life? I am sure that it would be boring if i had to stop eating the unhealthy stuff completely. I think that it is important to enjoy the unhealthy things some times to have a happy life. IBS is basically that your digestive system is stressed and don't digest everything and it gets stuck in your intestines, producing gas and your stool gets irregular. I am certain that my intestines are damaged because of the stress i put it through when i was 20 (i am 37 now). I delivered news papers at night and my eating and sleeping pattern was messed up. I started to spend a lot of time with friends playing computer games, eating tons of frozen pan pizzas and i drank sodas with that. I ate whenever i was hungry and not on specific times and went to sleep when i was tired. My stomach got so upset that when i was delivering news papers i would get acute diarrhea and had to run to the bathroom. And the stress to finding a toilet at those hours was a stress in itself. I got a lot of exercise because of my job, but i had to quit that job because of the stress it gave me and it did not pay well. That caused me to get next to no exercise because i had a rough time finding a new job, while continuing to eat bad things and eat and sleep at irregular intervals. Because of my love for computer games i spent most of my days in front of my computer and i do so now aswell, when i am not working. I also had a period when i was 20 where i drank a lot of alcohol every weekend with my so called friends at the time. I am certain that my way of living when i was 20 up to 32 caused my IBS. I try to be more active and i eat better now but it is far from perfect. I follow a diet with no gluten and lactose in it, i avoid apples and most types of onions due to the IBS. There are more things that i must avoid according to my FODMAP diet. But i still have issues. I do try to eat more vegetables. The FODMAP dietitians claim that i should eat often and smaller portions because it is not good for my stomach to be hungry and it needs something to work with. But its also not good to eat too much because it is hard for my stomach and intestines to digest a lot of food. So my second question to you is: I don't know if this is something that you can answer or not. If i mix your intermittent fasting with the FODMAP diet (eat maybe 2 times per day and avoid the things that upset my stomach), eat more fish and chicken and less red meat etc, could my IBS be cured? Recently i started eating less red meat (trying to eat less) and i eat more chicken and fish. I have been listening to your podcasts for a few days now and i am taking what you say to heart. I always put sugar in my tea, but i will replace the sugar with stevia. I have a standing desk that i just started using that function on so that i stand more. I will include ecological/organic vegetables in my diet aswell. I have a gym card but my current workplace is far from any gym atm and i can't take the bike to the gym because of winter and i don't have a drivers license. But i do walk to and from my work which is about a 40 minute walk (my IBS do prevent me from working every day because of stomach pains), i do try to get out for walks most days even when i am sick or off of work. I am goin to another workplace in a few days that have a gym in the same building and i am looking forward to that so i can start working out again. And when spring comes i will get on my bike and start to work out at the same gym as my fiancée. I do feel it in my body when i get less active because my knees starts to hurt and i get more back pains. I share your websites with my family so that they can learn from you and start to have a healthier life. My friends are sadly and most likely a lost cause and that makes me sad. They are too locked into the unhealthy way of living. But i will tell them about you :) I thank you for your hard work over the years and i think that it will give me and every other person that listen to you, a long, young and healthy life :) I also ordered your book yesterday and i am looking forward to reading it. Reply @kasia5237 @kasia5237 1 year ago thank you for sharing you knowledge :) 1 Reply @slimchei1939 @slimchei1939 1 year ago absolutely fantastic Reply @adrienku9197 @adrienku9197 1 year ago (edited) Hi Dr Sinclair , huge fan of your book, just to say thank you here😎 Aussie Aussie Aussie 1 Reply @RS-dq9pn @RS-dq9pn 1 year ago Wish they used diagrams to explain. Please consider for future episodes Reply @darlin4676 @darlin4676 1 year ago Por favor ponle subtítulos en español a tu videos. 1 Reply @edwardfosterart3848 @edwardfosterart3848 1 year ago Thank you. That was excellent Reply @bernzmaster @bernzmaster 1 year ago Big fan all along and a good start into 2022. Greetings everyone from Austria! 1 Reply @user-eg7iu7hn5j @user-eg7iu7hn5j 1 year ago 놀라운 정보 고맙겠습니다. Reply @JudytaNala @JudytaNala 1 year ago Great show! Reply @jackgoldman1 @jackgoldman1 1 year ago Secret of life from my doctor when he retired. EXERCISE, LOSE WEIGHT, EAT WHOLE FOOD, AVOID ALCOHOL AND CHEMICALS. How many people are doing this and what a difference it would make? Easy, simple, cheap, and it works. Do the simple stuff well. Get exercise, diet, and sleep right and other things fall into place. 1 Reply @tanyamoe1 @tanyamoe1 7 months ago Question: Dr. Sinclair, do you take athletic greens during your fast in the morning? Reply @Wildranges @Wildranges 1 year ago (edited) Whats your opinion of Resveratrol vs. Pterostilbene? Reply @agustinfodrini @agustinfodrini 1 year ago (edited) Regarding mTOR, you meant to say eating too much meat is a bad thing? Because as far of my understanding and knowledge goes, a little protein in the form of Chicken, Red Meat and Fish like Salmon is good for health. Also, muscle is one of the greatest indicators of health and in order to build and grow them you need protein. 2 Reply @lubo955 @lubo955 1 year ago I just received my resveratrol (1000 mg) but the color is yellow. The product is best to use before 05/2024. The ingredients are: Resveratrol, Microcrystalline, cellulose, Carboxymethyl, Starch Sodium, Magnesium, Stearale, and Black pepper extract. Do you think that this product is good to use? Reply @dionuyi8038 @dionuyi8038 1 year ago Good morning Dr, do you have any thing new on people suffering from sight loss due to glaucoma. Any help /advice or medication for reversing ageing in the eye? 1 Reply @SmilefitCoUk @SmilefitCoUk 1 year ago Hey David. Great podcast! I’ve read the book and followed you for a while now. I am however sad to hear that you read scientific papers while in bed! Perhaps you might entertain keeping the bed solely for the purposes of sleep and read them away from the bedroom. Also, hey Matt, good work 💪😂👍 Kind regards. Neil Reply @bobbobson4030 @bobbobson4030 1 year ago Is it possible to have AMPk and mTOR activated at the same time? Reply @mariateresaarias2130 @mariateresaarias2130 1 year ago Love it!! Reply @conniehudson4764 @conniehudson4764 1 year ago When protocols for extending lifespan without physiological or cognitive compromise are perfected, space travel may become more feasible for humans. Have you spoken with Lex Fridman, Elon Musk (or others) about this? Reply @SeanMurphy15 @SeanMurphy15 1 year ago we can engineer ourselves to what makes older animals live so long 2 Reply @em-tee8408 @em-tee8408 1 year ago Just commenting and listening to this podcast will make me look and feel younger and live longer. Yaaaasss 1 Reply @bb-vi9xh @bb-vi9xh 1 year ago Love the format. Reply @pranavsinghania6452 @pranavsinghania6452 1 year ago This is brilliant 1 Reply @sallysantiago7334 @sallysantiago7334 1 year ago I am currently listening to your book on Audible, watched your Ted Talk Boston, and several Youtube interviews,,, You had me at hello and how to polish the scratches on my old CD's! Reply @learncwithvisualstudiocomm4863 @learncwithvisualstudiocomm4863 1 year ago Is there anything that might have a reducing impact on tinnitus? Reply @georgeedgeworth915 @georgeedgeworth915 1 year ago Brilliant, loved it.... could have been done in twenty mins though. Reply @vivek7351 @vivek7351 1 year ago Very informative my last few decade my dream is to live young till I have natural death Reply @ronisapir @ronisapir 1 year ago WOW GUYS! YOU BLEW UP MY MIND! THANKS ALLOT!!!!! Reply @pahan9392 @pahan9392 1 year ago Aging is a fight you can never win. It's the reality. Maybe you can slow it down, but for how long 🤔. It's inevitable. Reply @Efrosyni300460 @Efrosyni300460 1 year ago Congrats ! We are here to listen and understand ! 1 Reply @adexmokson7185 @adexmokson7185 1 year ago I came here from Dr. Huberman and I’m loving it just like Dr. Huberman podcasts. 1 Reply @abstractTYPE @abstractTYPE 1 year ago He's 52 y.o. He definitely knows what he is talking about. Reply @eldukequimera0437 @eldukequimera0437 1 year ago Love it! Reply @valeriepierre7297 @valeriepierre7297 1 year ago How can you replicate the effects of metformin naturally without taking the chemical? 1 Reply @Constantinelatting @Constantinelatting 1 year ago Looking forward to more Reply @paulwolf3302 @paulwolf3302 1 year ago (edited) Fact: lots of people live into their 80s, but almost no one lives beyond 100. There is a cliff there that we are all going to walk off of. Until the reason for this hard limit is known, human lifespans won't be extended. DNA methylation tests might tell you how bad your health is, and the chance of you making it to 100, but I have yet to hear a satisfactory explanation of the hard limit at ~ age 100. I'm familiar with the "Pillars of Aging" and DNA methylation tests. That's like trying to understand covid by listing its symptoms - sore throat, fever, etc. It is not a combination of a dozen different things that are gradually degrading over time. There is a hard limit and something is preventing you from living any longer. Telomeres could be the culprit, but I doubt it. I take NMN and sometimes gotu kola, which may help with telomere shortening, but I'm skeptical that this will actually extend my lifespan. I feel like there must be some other mechanism to explain why almost no one lives past 100. Reply @DarkNavy96 @DarkNavy96 1 year ago Is it possible to get NMN from other sources besides supplementation? For example foods rich in it. Reply @jordanmatin8498 @jordanmatin8498 1 year ago Hello! Is it better to wear gloves during winter or is it better to expose one’s hands to prevent them from aging too quickly? 1 Reply @alexnickolaev @alexnickolaev 1 year ago Oh, you finally created a channel. Congratulations! 1 Reply @lukenewton2721 @lukenewton2721 1 year ago So glad this is out! 1 Reply @caroll9858 @caroll9858 11 months ago My mom has just celebrated her 92nd birthday. Her Orthopedic surgeon joked that he wanted to isolate her gmome for research into longevity.... Reply @ulisescampos1803 @ulisescampos1803 1 year ago History in the making. Reply @shawnrise5362 @shawnrise5362 1 year ago Question for any who may truly be able to answer & not let ego get in the way. His description of If your brain cell, woke up Tmr & decided its a liver cell, to me sound much like today's world of a boy being born a boy & waking up one day & deciding its a girl. This to me sounds the same. The actual body is so confused by the processed food & pharma (Vax) that the body stops being able to identify itself. 2 Reply @lynnj0750 @lynnj0750 1 year ago @david Sinclair! What an amazing podcast! I couldn’t help but notice that your podcast on anti-aging is set with a backdrop within very dated room! I can fix that! It’s what I do (timeless and classic interior design). Want to trade resources? lol Reply @JohnDeanMusic @JohnDeanMusic 1 year ago Excited for this episode. Here by way of Dr. Huberman! 1 Reply @TNTlife28 @TNTlife28 1 year ago This is sick! Love it Reply @penmaenmawrdefiant1146 @penmaenmawrdefiant1146 1 year ago Does anyone have any advice for nerve regeneration? 2 Reply @YoYo-gt5iq @YoYo-gt5iq 1 year ago Regarding the cheek swab, I like the idea that after a night if partying or exercising, I can see the effect(s). Reply @rockytunes89 @rockytunes89 1 year ago love this guy 1 Reply @petereriksson6760 @petereriksson6760 8 months ago I get curious… have any of these methods been tried to help kids with Progeria? Reply @brucebrisbane2912 @brucebrisbane2912 1 year ago The elephant in the room regarding David's perspective is people don't suffer equal deterioration of all body organs/systems/tissue. One or two organs (or systems) deteriorate quicker, hence why all people don't die from the same cause. So there cannot be a single solution that stops all organs/systems/tissue from aging. Reply @rizzobitz @rizzobitz 1 year ago (edited) What about the babies who's thymuses were taken out during heart surgery? My son had complete thymectomy and now has severe immunodeficiency. What can I do for him please? He is an adult now. 1 Reply @ryanmason3368 @ryanmason3368 1 year ago That was amazing! Reply @MegaSumit1996 @MegaSumit1996 1 year ago Great great great just super great just super excited for this podcast Reply @jimparsons4312 @jimparsons4312 1 year ago He takes 1g NMN, 1g resveratrol, Vitamin D, K2, 83mg aspirin, avoid sugar, bread, pasta, skip one meal a day, get your blood tested, don't smoke, avoid plastic, excessive UV exposure, X-Rays, CT scans, sleep in a cold bedroom, do cold exposure, do exercise.👏👏👏👏👏 1 Reply @RunToTheHills999 @RunToTheHills999 1 year ago Can't wait for the next episode 1 Reply @conocimientocritico9270 @conocimientocritico9270 1 year ago Wonderful!! Reply @albertcieplinski1870 @albertcieplinski1870 1 year ago Huberman vibes, good stuff. Thanks guys! Reply @hansschenker @hansschenker 1 year ago David has an ambitious goal - but it is interesting! 1 Reply @kamlingwong987 @kamlingwong987 1 year ago Thank you so much !!! Reply @kimwolfe345 @kimwolfe345 1 year ago So very thankful! 1 Reply @MountainwithaView @MountainwithaView 1 year ago (edited) I believe we're in less order as we age but also as we replicate, breed....imagine if we Defraged ourselves or even dna over thousands of years....we could only go back to the beginning......once we reach perfect order we get our start date.... Reply @momoflily @momoflily 1 year ago Taking notes and lovin it!! Reply @watershedbarbie9685 @watershedbarbie9685 1 year ago (edited) We age because it is part of the natural cycle .That is why you can grow such great food with compost. Reply @newview8371 @newview8371 1 year ago I hope to see more in future Reply @monastephens8577 @monastephens8577 1 year ago What tests can we currently get to see our biological age that aren't scams? I see Viome has a test for that but am not sure how trustworthy they are. Reply @liviumirceavomir2006 @liviumirceavomir2006 1 year ago Hello, what happens to the offsprings of the mousses that have received the treatment that delays their aging? That's of course if you made them reproduce. Reply @imransuhail82 @imransuhail82 1 year ago The starting reminds me of the Huberman Lab podcast and thats a complement 🤩 1 Reply @pootwilla @pootwilla 1 year ago Does your body get so used to fasting and being under threat that you can plateau and not get as many benefits after time? 1 Reply @londonspade5896 @londonspade5896 8 months ago Regarding age reversal, would we lose our memories? Reply @michelem226 @michelem226 1 year ago Aren't the negative effects of iron from heme iron? I thought non-heme iron from plants is fine. Also, antioxidants... aren't they important for preventing cancer? Cancer is the #2 killer in the U.S. Heart disease is number one, and it's my understanding that it's generally caused by eating too many animal products. 1 Reply @jds1259 @jds1259 1 year ago Is there any publication on how does botox affect longevity? 1 Reply @Neeko_Z @Neeko_Z 10 months ago curious, which scientific papers/journals does your team read, also dating how far back? Reply @mikesmith4337 @mikesmith4337 1 year ago Sounds like we need a new updated book. 1 Reply @littleshotofficial2858 @littleshotofficial2858 1 year ago Dr David Sinclair We need next podcast on mutation 2 Reply @groid1005 @groid1005 1 year ago I don't think immortality is the word when we reverse age because that coorelates the whole notion that we won't ever die even if we try to kill ourselves. Reply @musclebone7875 @musclebone7875 1 year ago We age because of time! 1 Reply @ronjean6034 @ronjean6034 1 year ago Love it all but would like to have contacts for various tests in Melbourne Australia. Reply @marcellocapone4925 @marcellocapone4925 1 year ago I listened to this today, onto downloading the next ones now. Reply @v_dl7511 @v_dl7511 1 year ago I wonder if there is some epi-age of stem cells. That is not the all other cell age. And still, besides their immortality, they halt at the time. Time when we could say that they aged. What about epi-age of stem cells? 1 Reply @mmgp5919 @mmgp5919 1 year ago I wonder what science may say about raw fruit diet. This trend seems to be more and more popular and there are many people on You Tube advertising this lifestyle. Is eating that many fruit harmful or accelerates aging? Some eat 10 or more bananas or drink almost half a gallon of orange juice at one sitting. What is the impact of fructose on aging? Reply @douglaswallace7820 @douglaswallace7820 1 year ago I read and watch everything I find by Dr. Sinclair, but also other scientists (Specifically, Kaeberlein and Stanfield). There's a lot of contradictory information from the others specifically about resveratrol and metformin. Who should I believe? 1 Reply @nazanerdem9774 @nazanerdem9774 1 year ago Hi from Istanbul, your own channel at the end, so happy to be here. Thanks Dr.Sinclair. 1 Reply @IonBelu @IonBelu 1 year ago Is AMPK activated more by fasting of by taking Metformin? Reply @a.c.3243 @a.c.3243 1 year ago my hero…handsome doc.i have ur book and following u since u started Lifespan…im almost 71 i feel great Reply @crystalward8467 @crystalward8467 1 year ago Hey Dr sinclair, a thank you to your sponsors and please don't turn into the hulk,, I can totally see that lol love your work👍 Reply @MinMin-kv3rv @MinMin-kv3rv 1 year ago (edited) I see conflicted info about Metformin side effects and usage on internet. Yet, I'd be willing to try it, since my very healthy life led mom died from cancer quite young (no genetic cause). How do I go about getting this drug in Europe? 1 Reply @mehdik.4984 @mehdik.4984 7 months ago Is it just me thinking tihs, or is David really a machine? Reply @stephanmartin5030 @stephanmartin5030 1 year ago You definitely look younger but do you worry about muscle wasting. Usually it starts in your 40s but really picks up steam in your 60s. Having low circulating amino acids is major component. Reply @ErikApostol @ErikApostol 1 year ago If I need to suppress mToR, does that mean I can't build big muscle? 1 Reply @dominikd9834 @dominikd9834 1 year ago CANT WAIT FOR NEW ONEEEE!!!!!!! Reply @musikinspace @musikinspace 1 year ago Wow, my year is off to a great start! 1 Reply @mjoh090 @mjoh090 1 year ago Where can we find disclosure information about any boards/organisations that you are both advisors to, and the companies you are invested in? 1 Reply @brucebrisbane2912 @brucebrisbane2912 1 year ago Geneticists and other reductionist scientists always talk a big game...... I'd be happy for them to tackle simpler subjects....like what is causing, and how to stop, the epidemics of autoimmune diseases, allergies, obesity, inflammatory arthridites, autism spectrum disorders. Reply @petravazanska5707 @petravazanska5707 1 year ago My great grand mother lived until 100. She had 12 kids and she hated food, she didnt eat much, didnt care about it. Lot of physical work in farm. Question is, was she happy? She never smiled. 1 Reply @masiiharwood6082 @masiiharwood6082 1 year ago Brilliant 👏 thanks 🙏💖💚💐😘 Reply @aangpearce2700 @aangpearce2700 1 year ago Im ready to have my mind blown. Or rather de-aged Reply @agnezaliene203 @agnezaliene203 1 year ago Just want to say massive Thank you. 👍 Reply @jeffmiddlebrook5251 @jeffmiddlebrook5251 1 year ago David, does the Resveratrol and NMN need to be refrigerated when shipped to us? Reply @dr.samierasadoonalhassani2669 @dr.samierasadoonalhassani2669 1 year ago THANK YOU,START TO LISTEN AT 14 MINUTES ,IF YOU KNOW ABOUT HEALTHY LIFE SPAN.WE NEED ZERO COST TOOLS AND PROTOCOLS TO EMPLOY IN OUR DAILY LIVES LIKE BREATHING ,WATER ,LIGHT,SLEEP,FOOD,STRESS,SOCIAL CONNECTIONS,EXERCISE ,DAILY MOVEMENTS.WE NEED THE TOOLS OUR ANCESTORS USED BECAUSE OUR GENES ARE LKIE THEM,HOW TO IMPROVE OUR MICROBIOTA SYSTEM AND OUR GUT NEW LY DISCOVERED NERVOUS SYSTEM.THANK YOU. 1 Reply @Parkourmattstrong @Parkourmattstrong 1 year ago Oh I’ve been using athletic greens every morning since Christmas 2021 I had no idea it was recommended by Sinclair’s himself 1 Reply @baynative @baynative 1 year ago one word: AWESOME 2 Reply @devtestdevtest9014 @devtestdevtest9014 1 year ago Brilliant! 1 Reply @nicolomadia8083 @nicolomadia8083 1 year ago what do you think about the wim hof method? is that something that could help preventing X differentiation? Reply @StuntmanDan03 @StuntmanDan03 1 year ago (edited) Here for the history of humanity. 1 Reply @ReidKimball @ReidKimball 1 year ago When Dr. Sinclair said, "When I was in my twenties..." and I thought, wait, you aren't in your twenties?! OK I'm sold. 1 Reply 1 reply @bottomfeeder5189 @bottomfeeder5189 1 year ago All I need now, is a reason to prolong life, lol. Reply @fadilahilda @fadilahilda 1 year ago Yeayy happy finally got podcast by yourself 💥 1 Reply @pbeeche @pbeeche 1 year ago The podcast is here! 🥰 1 Reply @gcorreaf1993 @gcorreaf1993 1 year ago i've been waiting this for a looooong time, éxito! Reply @deanc.1394 @deanc.1394 1 year ago Your Nobel is on the horizon. You have my vote Reply @angelinesarol5616 @angelinesarol5616 1 year ago JUST STARTED WATCHING AND PURCHASED ATHL GREENS, LOOK FORWARD NEXT EPISODES Reply @68868s @68868s 1 year ago DHEA, Metformin, and growth hormones: I am confused, isn't DHEA a growth hormone? 1 Reply @haythamhaytham5383 @haythamhaytham5383 1 year ago it's the best podcast like this video,,, 2 Reply @young-forever-nmn @young-forever-nmn 1 year ago 太棒了！ 1 Reply @Nash9r @Nash9r 1 year ago Damn, I hope NMN will get cheaper soon. Here in Germany it is pretty expensive when you want a trustworthy source. Reply @iluminative @iluminative 1 year ago Duty to family to be healthy, rather than them taking care of you for 20 yrs! Salute amazing Reply @adeyemikayode3039 @adeyemikayode3039 7 months ago Using this as reference, I think scientific findings should be related to the public using examples like YouTube. Rather than confining within the walls of scientific journals. 1 Reply @rufusreloaded1043 @rufusreloaded1043 1 year ago That's the great thing about the internet. You just choose what you want to be true and search the internet. Somewhere someone will be telling you what you want to hear. It's like shopping. Reply @moonjeeworld @moonjeeworld 1 year ago Can a post manaposal woman who is very healthy return to the reproductive stage, ovulation, and have conceived baby normal human process? Eagerly waiting for your response. Reply @henchgamer6996 @henchgamer6996 1 year ago Yes thank you so much 🥰 Reply @SylvieMischel @SylvieMischel 1 year ago Der Dr. Sinclair, Is there a possibility to get in touch with your sponsors and finding the supplements/medicine you take in EUROPE? Thanks a mil ‼️ I have been a great fan since I red your book 2 Y ago 🙏 1 Reply @luckssj @luckssj 1 year ago Do you know about Glycocalyx, and why do we need it? And does NMN work with it? Reply @skyrider4789 @skyrider4789 1 year ago Great stuff guys. Thank you! What are those pads on Mathew's MacBook? Reply @planetaryPoem9 @planetaryPoem9 3 months ago Why do the cells start losing their memory in the first place? Reply @Man_with_no_name @Man_with_no_name 10 months ago Yogi's in India have been meditating in caves and somehow been able to live upto 200 solar years, is it somehow related ? I think they are able to slow down time for themselves through the study of the breath and yoga. Reply @donrounds7791 @donrounds7791 1 year ago I have a small anxiety that we may never "get to that later" 1 Reply @franceslynn4094 @franceslynn4094 1 year ago I do like your content, and I am a big fan of Dr Huberman, my personal questions I hope you cover in your podcast us about Cancer, is that a disease of aging? Children die of brain tumors old people die of brain tumors, How can someone who has had cancer apply anti-aging strategies without encouraging cancer to grow again? Everything is contradictory with regards what a cancer patient can do to help their longevity, high fat low fat, no sugar, no animal protein/ more animal protein it gets exhausting. Some cancer treatments cause aging in the process, especially breast cancer treatment 1 Reply @elensayista8988 @elensayista8988 1 year ago Wouw David finally dared to say we can become biologically inmortal! Mainstreet aint prepared for that talk! 1 Reply @khalid1130 @khalid1130 1 year ago Dr. David we need your answer on what are the best brands of NMNs or at least how can we know what is good NMN brand. 1 Reply @rhondaphillips8456 @rhondaphillips8456 7 months ago The Bible says no one will live past 120. God’s plan is trustworthy. However, I believe He wants us to live healthy and long, just as you are helping us to do. Thank you. Reply @pongthepn @pongthepn 1 year ago Thank you so much. Reply @sauliusplevokas6188 @sauliusplevokas6188 1 year ago Amazing! 1 Reply @theartofancientegyptianmet1747 @theartofancientegyptianmet1747 1 year ago Love program! 1 Reply @Wanderer-uc1sj @Wanderer-uc1sj 1 year ago YAY!!! It’s finally HERE! 👏🏻👏🏻👏🏻👏🏻 Reply @parulgoyal2609 @parulgoyal2609 1 year ago Ayurveda is talking about Holistic approach for ages.I am glad modern science is reaching there.Amazing podcast! 1 Reply @thatchessguy7072 @thatchessguy7072 1 year ago I read your book, interesting stuff. Reply @newview8371 @newview8371 1 year ago To live longer means people get stay at their job longer. Holding that job longer meaning that job is not available to younger people. Reply @ioanaconstantin7151 @ioanaconstantin7151 1 year ago Wow, this is heavy, interesting and exciting. 1 David Sinclair Reply @pb25193 @pb25193 3 months ago Normally i think of this type of content as quackery but I just googled this guy's name, and he is 53 years old. He looks 31! He needs no additional credentials.. 1 Reply @mahshidlife544 @mahshidlife544 1 year ago (edited) Awesome insight. Great memories of Cassette tapes. 1 Reply @peterz53 @peterz53 1 year ago @ 19 min on Bowhead whales - Vera Gorbunova gave an excellent talk at ARDD2021 which identified CIRPB as the key upregulated gene responsible for double strand break DNA repair. which she thinks is a key driver of aging. Bowhead whailes live in very cold water and have, compared to us, a low core body temperature. Turns out that low temperature upregulate expression CIRPB. So, to specualte, it might be helpful to periodically get cold to upregulate our own CIRPB gene. After my cold shower I sit in a tub of cold water (~72F) for ~5 minutes. If nothing else it makes me feel good.. 2 Reply 2 replies @criticalanalyst7546 @criticalanalyst7546 1 year ago too fascinatingly illuminating. Reply @tonyinfinity @tonyinfinity 1 year ago He just said on Rogan that he doesn't take any "greens" supplement, and also always says he doesn't sponsor any products. Yet here we go, tell us about the products you're pushing. 1 Reply @Jessica-kk1cz @Jessica-kk1cz 1 year ago Yay! It’s finally here!!! Thank you!! Reply @MagnesiumAddicts @MagnesiumAddicts 1 year ago I see the intro for this episode is inspired by the Huberman Lab podcast lol Reply @themasstermwahahahah @themasstermwahahahah 1 year ago How much longer is the type2 diabetes on metformin lifespan than normal? Reply @rivernelson7239 @rivernelson7239 1 year ago David, if I drink milk in my tea or coffee each morning, am I breaking my 16 fast? Cheers Den Reply @Iris-qd9cs @Iris-qd9cs 1 year ago Love this , love from Germany Reply @TimeRiderTime @TimeRiderTime 1 year ago Thank you! David Sinclair Reply @ineskhaz1203 @ineskhaz1203 1 year ago Dose the longevity theory might help and works with the ability of women getting pregnant longer age ?? Reply @cliftonnobles5600 @cliftonnobles5600 1 year ago Perhaps "aging" is better thought of as biological degradation. 1 Reply @leadimentoobrien1221 @leadimentoobrien1221 1 year ago Yay!! This will keep me busy while I take my 10,000 steps with my fitbit 5 on the treadmill. Reply 1 reply @jonparrott4081 @jonparrott4081 2 months ago Fasting and challenging nutrients ARE EXERCISE. At the cellular level. Reply @prathutayade2218 @prathutayade2218 1 year ago I will meet you some day today I am 18 yrs old. My intrest in biotechnology, genetics increasing day by day. Hope I will meet you ❤. 1 Reply @winbalingit8502 @winbalingit8502 1 year ago Yay!!! It is finally here!!!💃🏽 I am happy dancing!!!😁👍🏽 1 Reply @alexandrosd6781 @alexandrosd6781 1 year ago Thank you! Reply @AnisaShyti @AnisaShyti 1 year ago What is the double edged sword of all these interventions/supplements? Anyone else experiencing “too good to be true” or “Sapolsky wanna-be”? This looks like a spectacular business model… especially if it doesn’t work… no one to hold anyone accountable… And the real worries would start if it works… 1 Reply @goodphone156 @goodphone156 1 year ago It is interesting the possibility of reversal agjng , but the problem is how much cost currently for a normal people? Reply @slimmykimmy7774 @slimmykimmy7774 1 year ago Incredible. 1 Reply @morganathoth9083 @morganathoth9083 1 year ago I understand that lobsters do not age. Have they been studied as well? Reply @sonals2021 @sonals2021 1 year ago My son asked me the reason why dogs and cats age differently from us. Why are their years different to ours! Reply 2 replies @ryanflow9870 @ryanflow9870 1 year ago Woah! Love this Reply @c.l.montoya2972 @c.l.montoya2972 1 year ago David, what NAD(3?) supplement would you recommend? Do tell. Reply @marinafoglietti9351 @marinafoglietti9351 1 year ago (edited) Good evening, I am a woman 74 age. My only problem is to love very much italian small coffee. I drink it twice a day, one in the morning and one another after lunch. That's why I eat one egg in the morning before coffee. At lunch I eat a big green salade with olive oil and another egg. At dinner meat or fish and vegetables. Three days a week I do some sports at home and assume vitamins C D3 B Complex and Omega 3. That"s all. Is it all right or I have to change everything? I haven't any pathologies. Thank you very much indeed ❤ 1 Reply @cheryld6920 @cheryld6920 1 year ago I love the podcasts and have the book, however I have to disagree £79 a month for a scoop a day of super greens is not affordable for everyone. As a women who lives on her own I could not afford this plus a good diet and supplements. 1 Reply @killthemall55 @killthemall55 1 year ago How would i exercise what you are saying if i do lot of cardio and weight training? I have to eat certain amount of protein. Reply @fgnsdfnbnd @fgnsdfnbnd 1 year ago I look forward to future podcasts. Thank you. However, the claims in this first podcast seem beyond hubris. 1 Reply @km-vm9yl @km-vm9yl 1 year ago I checked your site do you run genome sequencing? I know your research lab but thought you did for payment and use for research. 1 Reply @MN-iu9pd @MN-iu9pd 1 year ago Big thank you ❤️❤️🙏🏼🙏🏼✊✊✊ 1 Reply @paulaukena2654 @paulaukena2654 1 year ago THANK YOU !!!!!!!!!! 1 Reply @PhysicalMath @PhysicalMath 1 year ago (edited) Pinot Noir must be good for one's health because, like most other medicines, it tastes awful. Reply @drippie1088 @drippie1088 1 year ago Andrew is doing way better because he's alone, two people are so blurry. David, I hope you adjust. 1 Reply @husamalfaouri2070 @husamalfaouri2070 1 year ago the essence of whole matter that everyone want and priorities to look younger , healthier and attractive , on living longer Reply @jonjones5152 @jonjones5152 1 year ago So lengthening the Telemeres is just claptrap? Great new channel 🤯😉👍 Reply @MrNikeNicke @MrNikeNicke 1 year ago "We're not selling anything, so you can trust what we say" -> "Sponsored by these companies directly related to what we're talking about". Hahaha 2 Reply 1 reply @swg6443 @swg6443 1 year ago (edited) Hello, you say you only eat one meal a day, in the evening, on the recent Dr Huberman conversation. So how do you drink Athletic Greens every morning?? Also if the gallbladder contracts to synthesise even a thimble full of nut-milk (I saw this on an ultrasound last week), how does having a spponful of yogurt/Olive oil not break a fast? I'm really confused about conflicting information about fasting. I do not mean to be a pedant but this is a direct contradiction. Also please can you talk about and research the effect of changing hormones in women and how this can be best managed. It feels like most of this research and advice is geared towards males predominently. Thank you so, so much and thank you so much for all that you do xxx. Reply @deepdoubtsboutu6898 @deepdoubtsboutu6898 1 year ago (edited) You said you dont take Vitamin Supplemets in another Video ... Arent these Athletic Greens marketed as an expensive replacement for Vitamin Supplements ? Is it really worth the price of monthly payments on a small German Car rather then Multivitamin supplements ? 1 Reply @loriej2687 @loriej2687 1 year ago Been waiting for this! Reply @xHideousFoxx @xHideousFoxx 1 year ago great sci-fi set up. exponential cost every time you reset your aging clock leads to resource hoarding etc etc. wealth inequality etc etc. fancy music and explosions with laser sounds. Reply @cyberfeedforward4032 @cyberfeedforward4032 1 year ago In the future, people will say, "I feel sorry for our ancestors. They all died when barely out of diapers." 1 Reply @opheliaelesse6626 @opheliaelesse6626 1 year ago how can humans learn to be nicer to the planet, animals, life itself? any ideas? depressed greetings whilst thinking how much more pain a longer living humanity will cause ... Reply @kornelg8584 @kornelg8584 1 year ago This guy is a real life Sheldon ;) Reply @harrylange3028 @harrylange3028 1 year ago pure Gold. Reply @tramsgar @tramsgar 1 year ago Having supplement-selling sponsors is ok, but at the same time saying 'I'm not selling any supplements' is a bit contradictive. 2 Reply @manunoyonify @manunoyonify 1 year ago Thanks u. GHB is sold as an anti aging compound.... Is this true please ? Regards 1 Reply @Neeko_Z @Neeko_Z 8 months ago yes, bagging on doctors for sure. Maybe they said over the years eat better and exercise, but they would never say it with any enthusiasm. At the same time telling people what they have is not curable but manageable with medications. Doctors have done more bad than good. What did Linus Pauling and his colleagues talk about??? They were all blacklisted. Reply @Htrac @Htrac 3 months ago I can't find anything about ex-differentiation(not helped by the subtitles calling it x differentiation). All the results are just about maths, but if I put it in quotes then I just get links to this podcast. Reply @AnkushSharma-zv5hv @AnkushSharma-zv5hv 1 year ago more power to you Reply @pedecia @pedecia 1 year ago Diabetes type 2 is the inability of the cells to absorb the glucose because filled with fat and oil. If in a diabetic type 2 patient you give for 3 weeks a low fat (10% or less), not oil plant based diet he will see his disease completely reversed. One thing to notice is that the patient will need to be monitored by a doctor to adjust Insulin level administration as he will require less and less insulin as more his cells will clean up the oil and the fat in them and becoming efficient again to re-utilize the glucose. 1 Reply @mirrameez10 @mirrameez10 1 year ago I love you guys ....stay safe 1 Reply @DarkNavy96 @DarkNavy96 1 year ago Someone please post the best NMN supplement a budget pick and a quality pick would be appreciated 1 Reply @Torch_Vs @Torch_Vs 1 year ago I wish he wouldn't lie about drinking athletic greens Reply @yourcoachbladimirsantos5136 @yourcoachbladimirsantos5136 1 year ago Does anyone knows where david is getting the supplements from? Reply @deepdoubtsboutu6898 @deepdoubtsboutu6898 1 year ago Everyone s rushing off to buy Athletic Greens to lengthen their lifespans as implied with its connection to this Podcast ... How much longer will you live on Athletic Greens ? Reply @sniperking6321 @sniperking6321 1 year ago Dr. David Sinclair will go down in history mark my words Reply @LookingAway359 @LookingAway359 1 year ago Very fascinating. I would however recommend changing the background of the podcast. Reply @ryandoherty9696 @ryandoherty9696 1 year ago (edited) It sounds like we should all be eating sugar until we develop type 2 diabetes so we can be prescribed metformin. Point is, unless metformin or rapamycin are available to the public what good is this discovery? Dr. Sinclair, for example, has been able to give himself metformin for well over a decade, but that isn't reality for literally everyone else. So, what's the solution? 2 Reply 1 reply @user-fy6tj8up4x @user-fy6tj8up4x 1 year ago Finally. 🙏🏼❤️ 1 Reply @everend_xyz @everend_xyz 1 year ago 💞✨ Reply @andreacrouch36 @andreacrouch36 1 year ago So excited!!!!!!!!!🙌🏻 Reply @guidoaxmann5167 @guidoaxmann5167 1 year ago @David In Episode 52 of Andrew Huberman's podcast on 27 December 21 you say at minute 1:27:30: "I don't take multi-vitamins." In your new podcast you promote Athletics Green and claim: "I've been drinking Athletic Greens every morning, pretty much for the last few years ..." Please clarify this potential inconsistency. Do you take Athletics Greens every morning? If yes, why do you say you do not take multi-vitamin, which Athletics clearly is. Thanks! Reply @ngaiomcgee419 @ngaiomcgee419 1 year ago just started listening to the audible book, it's complicated, so I thought I'd track you down here and then go back to it. Reply @tamidemayo1108 @tamidemayo1108 1 year ago Will you go beyond the science to discuss the moral issues of anti-aging? Is it necessarily a good thing for humans to live so much longer? What are the social and ecological impacts? What happens when only some people can access extreme longevity therapies? 2 Reply 3 replies @BrendanMyrden @BrendanMyrden 11 months ago So DOPE. 1 Reply @santiagosanucci8532 @santiagosanucci8532 1 year ago with this podcast and huberman's podcast we r gonna live forever jajj Reply @carollouiseorrell @carollouiseorrell 1 year ago I am disappointed that David Sinclair is now a spokesperson for non wholefood supplements or those which are not eaten in their natural forms. He has stooped to commercial gains. 2 Reply 1 reply @GsySaxMan @GsySaxMan 1 year ago Your view of metformin, as some kind of wonder molecule, is not shared by this placebo controlled study - Effect of Metformin and Lifestyle Interventions on Mortality in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study - Diabetes Care December 2021. Any comments on the findings of this study would be great, but something tells me that all I will hear will be the silence whistling in the trees....Btw I read Lifespan when it was published, and you are correct its narrative is well behind the curve now. 1 Reply @lucianosuarez9563 @lucianosuarez9563 1 year ago And here we gou ... in the search of the new Paradigm. Reply @catalinghinea7583 @catalinghinea7583 1 year ago I think fasting is the discovery of the millennium . The things religions of the world knew because they are preaching it for millennia but doesn't says really why and now we know .I now wonder wich other secrets religion has and not saying. Did you knew that actually the prayers are actually a meditation methods?? Reply @kenneen0cail @kenneen0cail 1 year ago So basically, no one going to believe me when I tell them this is a thing.....I guess better find a way to invest in company's that are going to start building around this science. 1 Reply @johnmartinsen7623 @johnmartinsen7623 9 months ago Why are you afraid to have a conversation with Dr Paul Saladino? He makes some good points that you clearly don't want to acknowledge. Upton Sinclair said it best..."It is difficult to get a man to understand something when his salary depends on his not understanding it." Reply @sandraslutz9489 @sandraslutz9489 1 month ago Hey Dave, just wanted to thank you and the company you co-founded MetroBiotec, for getting NMN banned by the FDA. I guess it doesn't make any sense to buy your book "Lifespans", since you can't get it anymore. Thus making the Metformin, NMN, and Resveratrol regimen impossible to follow. I understand you and your company tried to do the same thing with Resveratrol but failed. You shouldn't be holding out false hope to people, and then trying to make yourself rich. Reply @daquanlee6132 @daquanlee6132 1 year ago Lmaoo they have such different personalities. It’s like their passively agreeing 😂😂 Reply @3pendont4 @3pendont4 1 year ago learn how to completely descale the human body . learn how to clean all of your filter organs. learn how to isolate and kill all unwanted microbes and parasites. learn how to control the immune system and all inflammation. learn how to grow good microbes. learn what simple nutrients needed to rebuild young cells. Reply @sunnyc8679 @sunnyc8679 1 year ago Never clicked subscribe faster in my (now hopefully extended) life. Reply @bejusu @bejusu 1 year ago Dr Sinclair carries huge respect to his peers, but Dr Matt Kaemberly, Dr Brad just act with jealousy and hatred. Very pity. 1 Reply @GabrielaHandalArt @GabrielaHandalArt 1 year ago Nobody has been told by a doctor to fast to improve their health or to live longer. The medical institution deserves all the shit it gets, because that's also the point of a scientific mind: to be open to have its ideas questioned. Reply @AdisMoshi @AdisMoshi 1 year ago (edited) I have a question, why would I want to live longer if I'm already tired? Not saying this is not fantasy, I may die looking better, but what about the financial aspect of living longer or healthier at an old age? Or what about work...? How long would a job have me, will i have to study even more (=more $$$) and..... That.... Why... And then how.... Soooo many questions.... Reply @jeannienelson1035 @jeannienelson1035 1 year ago Why is Sinclair lying about the benefits of resveratrol? Studies have concluded it isn't benficial, even when combined with yogurt or olive oil. What else is he lying about?!!!!! Reply @HiTechFX @HiTechFX 8 months ago Awesome! Reply @wdennis8 @wdennis8 1 year ago Everyone ages because God has made it this way. There is no way to prevent aging and eventual death of this body. You can prolong it by taking care of it but inevitably this life ends in death. This is why it’s paramount to prepare for the life to come by accepting Jesus Christ as lord and savior. He died for past, present and future sins of those who believe. He is in fact God and died without sin so that through his sacrifice, we might obtain eternal life with God. Tomorrow isn’t promised for those who die in their sins. You can’t eat and exercise your way into eternity. Yes I know this isn’t what your focus is but in my opinion, it should be. Thank you for your channel. 1 Reply @matzefritz @matzefritz 1 year ago The argument that you owe it to society to stay healthy to be productive is quiet authoritarian. First you should be able to live in a free society with no repression and also learn to live happily. What does it mean to live 200 oppressed years in slavery? This is my biggest critique to David Sinclairs work. He forgets this point completely. Reply @cheekybastard99 @cheekybastard99 1 year ago I'm afraid this technology will get out before certain people pass on. Reply @maxsoregon @maxsoregon 1 year ago So what about Bible recounts of people living hundreds of years? Kind of like the Sumerians knew more about space thousands of years ago, than we know today! Plus I heard recently we now have proof that mankind was created... there is absolutely no way we evolved from Neanderthal. Can't remember now specifics or how long we've been around, but we definitely created... we've always been humans! Reply @WernerLad @WernerLad 1 year ago (edited) Interesting subject, but how do you explain “blue zones” in the world. Especially where in 2 regions of Sardinia have many “centurions”. Yet on another region of the island there is a high number of an “adult progeria” called “Werners Syndrome”. 1 Reply @simonstephenson6764 @simonstephenson6764 1 year ago I’m a fan, having given eleven friends a copy of LIFESPAN. However I didn’t love this podcast. The frivolity goes too far and I would not feel comfortable sharing it with someone new to Sinclair. I’m not saying you should balance seriousness with fun like the NEJM podcast, which is at the “no fun” end of the spectrum. But placing the podcast at the Huberman Lab position would work. Reply @mirrameez10 @mirrameez10 1 year ago Great sir Reply @spacezoo5079 @spacezoo5079 1 year ago Some people have been eating well and exercising for hundreds of thousands of years but I don't think they were living to 150 1 Reply @syrupgoblin4920 @syrupgoblin4920 1 year ago The war on aging begins Reply @bootlegskate @bootlegskate 1 year ago (edited) Can you say anything about research on resveratrol and /or nmn interacting with levothyroxine? Partner takes 175mcg /day after thyroid cancer/no thyroid anymore and wants to take these but I can't make sense of the pubmed articles on them Reply @asada7972 @asada7972 1 year ago Thank you guys Reply @Coatch-monir @Coatch-monir 1 year ago Thank you 🌹 Reply @MM-qg5xh @MM-qg5xh 1 year ago Awesome! 1 Reply @ishtar0077 @ishtar0077 1 year ago (edited) 1:54 the caveman, lol. The average person works a lot. I'm able to listen non-stop to podcast that is 2 t 4hrs long in one sitting, even rewinding it. Reply @captainpike2468 @captainpike2468 1 year ago Yea …his OWN podcast …!! Bob Sagat and Norm McDonald BOTH followers of Sinclair , NMN and Resveratrol 1 Reply @vangiedangadang7263 @vangiedangadang7263 1 year ago This is legit David looks 30's!!! 1 Reply 1 reply @dottiepolly8564 @dottiepolly8564 1 year ago My gratitude to you thank you thank you thank you Reply @mysteryman7065 @mysteryman7065 1 year ago We age because we have NO CONTROL over the telomeres getting smaller and smaller. 1 Reply @andrewr76861 @andrewr76861 1 year ago Thoughts on intranasal NAD+? Reply @RipCity_TID @RipCity_TID 1 year ago 4:29 - "I'm not selling any supplement" Three minutes later: "anyway, you should all go buy this supplement" Reply @goodgreenenergy @goodgreenenergy 1 year ago Suppose the 200 year old harpoon was 50 years or older when it was deployed? Reply @raiderlife4478 @raiderlife4478 1 year ago i was wondering what happends if you havent eaten any meat. but you drink something with those BCCA all the ones you have talked about because I noticed some pre workout and engergy drinks have L-leucine L-valine and L-isoleucine. Ive stoped taking these types of drinks. till i get your input. 1 Reply @angelobadellino3922 @angelobadellino3922 1 year ago Is ALA acid be considered a metaformin alternatives? Reply @goodphone156 @goodphone156 1 year ago Not every body currently can, i think adopt this possibility. I mean for the huge cost. Reply @kefirheals7383 @kefirheals7383 1 year ago (edited) So, how can my husband and I get Metformin, so we can take a daily dose - and how can we get tested to determine our Biological Clock ? 1 Reply 2 replies @reallifevictoria914 @reallifevictoria914 1 year ago I wonder if Dr. Sinclair has heard of carbon 60 and the study on rats? Reply @adbc8737 @adbc8737 1 year ago ThankYou! 🌀💚🌀 Reply @chrisaustin4115 @chrisaustin4115 1 year ago Imagine if Michael Jordan Reverses his Age Reply @VentureCreek @VentureCreek 1 year ago The question is, why do we age Reply @hugex9796 @hugex9796 1 year ago Oh my god i am so excited! I.agine having 250 - 350 years yo experience Life! That would be so cool to learn and understand stuff! Reply @thatwasprettyneat @thatwasprettyneat 1 year ago Why does he say he's 50 in this episode? He was at least 51 since he was born in 1969. Reply @GrimaldiLuigi @GrimaldiLuigi 1 year ago Super exciting 😀 Reply @Hades44481 @Hades44481 5 months ago im 13 and really interested in this! Reply @rickhardtbreijn9821 @rickhardtbreijn9821 1 year ago Can you talk about Rejuvant please? Thank you. Greetings from Peru 1 Reply @alicebush108 @alicebush108 1 year ago Id like to know what age are we capable of living to? 150, 175? With the fasting and supplements + dodge cancers/ genetics. Reply 1 reply @dominikl2815 @dominikl2815 1 year ago So excited! Reply @carl-fredrikmartensson9231 @carl-fredrikmartensson9231 1 year ago I thought David Sinclair was doing intermittent fasting and then he reads an ad where he says that he drinks athletic greens every morning??? 1 Reply @evolve101 @evolve101 1 year ago (edited) You rockstar ;) David the man! Shrimps on the barbuueee ;) Kidding. read you where from australia.. Boring humor. Anyways.. You're the man! This will be interesting. Thanks. Peace edit: Great episode, this is going to be fun.. I agree. Reply @SquatFull @SquatFull 2 weeks ago This is storytelling until confirmed by other labs. Reply @irszgatti @irszgatti 1 year ago If John Scully is reading the comments, hopefully I've created another fan. Reply @rockyabhay @rockyabhay 11 months ago Can you find a way for humans to live for 5000 years? Reply @MyMeghana @MyMeghana 1 year ago Could you please update the levels link website? It seems to be incorrect as I cannot reach that site. Reply @LongPham-eg2pt @LongPham-eg2pt 1 year ago brilliant Reply @rdrevilone @rdrevilone 2 months ago HEARD metformin was in fact a drug being removed from drugs store Reply @celesteschacht8996 @celesteschacht8996 1 year ago Most of us can't do the testing or buy supplement :-( Reply @jorgenvons3568 @jorgenvons3568 1 year ago I am not able to buy metformin. Does David Sinclair recommend to take Beberine for those with no Access to metformin? Reply @maxb5957 @maxb5957 1 year ago Bought your book in German twice Reply @kennylo8423 @kennylo8423 1 year ago Wow! 🙏 Reply @sallycook8173 @sallycook8173 1 year ago How do you get a Dr, in the U.K. to prescribe Metformin? Reply @marcimareburger2524 @marcimareburger2524 8 months ago How do I sign up for a double-blind trial? Reply @pespsijackson3958 @pespsijackson3958 1 year ago (edited) i take 500 mg of curcumin daily and 18 hour fasting daily and big bowl of salad beans lentils rice Reply @squidartha @squidartha 1 year ago Happy to subscribe! Reply @richardmiddleton7770 @richardmiddleton7770 1 year ago Having children! Having children will age you! 1 Reply @NikaObolashvili @NikaObolashvili 1 year ago Really interesting 1 Reply @weinazhang2529 @weinazhang2529 1 year ago 👏👏👏 Reply @talksisters @talksisters 1 year ago Can you translate this into other language such as Korean? There are many fans in Korea Reply @nadirnft9712 @nadirnft9712 1 year ago Can we preorder the new book ? Reply @queensgambit4982 @queensgambit4982 1 year ago Does anyone think that Matthew sounds like Joe Rogan ? His voice has that similar tonality Reply @MultiGlobalnews @MultiGlobalnews 1 year ago You forgot to say how to stop aging , you spoke about slowing reversing but not stopping , I don’t want to reverse it I don’t want to slow it …I want to stop it 1 Reply @halmatone175 @halmatone175 1 year ago (edited) We can live long enough and we have planet that we discovered later we can live it Reply @SilhSe @SilhSe 1 year ago Is this the real Dr. David Sinclair channel??? 2 Reply @ardaraith @ardaraith 1 year ago What about alcohol? Will this be addressed? Reply @rosisunny9302 @rosisunny9302 1 year ago We don’t Realize we can dye any minute,we I’ve in a bubble and it can burst!We think we can live forever most people don’t,and go Jung! Reply @fredomacedo6304 @fredomacedo6304 1 year ago I thought this was going to talk about gravity lol 1 Reply @snowfirel7108 @snowfirel7108 1 year ago Dr. David Sinclair you look very young, around 24 years old now, can tell that you are reverse aging congrats! Wish it were possible to find the right kind of Resveratrol, every kind that money has been wasted on so far is brown, oh sure they have it packed in white caps, why not let people out there know which one is real so we don't keep wasting our hard earned money. Tks. 2 Reply @lindas2243 @lindas2243 1 year ago Can you talk about aging teeth? Reply @ErtanKanbur @ErtanKanbur 1 year ago Oh my God, that sponsor speech. HAHAHAHAhaha. 1 Reply @lovev9904 @lovev9904 1 year ago I'm an Independent Latino, Thank you!! 2 Reply @VideoStar-nw3mh @VideoStar-nw3mh 1 year ago Ok but there are people who don't gain weight or eat all the time and then I'll see them 5 years later.. they look like they aged but didnt gain any weight.. so can someone explain that?? Reply @slayeralchemist @slayeralchemist 1 year ago Kk but around 30 mins when he says this is what drs have told us often. I've never had anyone recommend fasting to me once. They actually recommend against it 🤔 Reply @lorilafferty4099 @lorilafferty4099 1 year ago Amazing human 1 Reply @MarkRollag @MarkRollag 1 year ago CONGRATS!!! I am subscriber 34,201 dont forget us when you have 1 million!!! 1 Reply @miroslavjuris1426 @miroslavjuris1426 1 year ago nice, but how one can get the stuff maybe some links to the products? Reply @nothinghereligma3363 @nothinghereligma3363 1 year ago Hiiiiiiii :) I’m happy you have a YouTube channel. Subscribed ❤️ 1 Reply @craig5698 @craig5698 1 year ago Just want to point out that David is 52. 1 Reply @kenwitness5844 @kenwitness5844 1 year ago To quote Mr Spock, 'fascinating'. Reply @dr.sammypryor @dr.sammypryor 1 year ago (edited) Naturopathic Doctors like myself have been teaching our patients about fasting, sauna, and ice baths 100s of years before I even became a naturopathic doctor! Go over to my channel and watch the playlist water fasting for tips on fasting. Reply @sarahsarah8053 @sarahsarah8053 1 year ago thank you. 1 Reply @primate745 @primate745 1 year ago He looks to be somewhere between 30 and 45… he’s 52 😳 1 Reply @mehedihasan-ui6qt @mehedihasan-ui6qt 1 year ago Goddamn it look at this guy! He looks 30! Reply @EnricTeller @EnricTeller 1 year ago $1.99 Thanks! Reply @vladimirvasilina1537 @vladimirvasilina1537 1 year ago Why only 8 episodes? :( 1 Reply @qijingfan5656 @qijingfan5656 1 year ago (edited) Please talk about trustworthy manufacturers for NMN and resveratrol , dosage of metformin. when and how to take them. Side effects ? 2 Reply 2 replies @rajadravid1501 @rajadravid1501 9 months ago CHF 100.00 Thanks! 1 Reply @yehongchen4341 @yehongchen4341 1 year ago Great！ Reply @myooz7 @myooz7 1 year ago Is it just me or Dr.Sinclair looks like an Elf? 2 Reply @spacezoo5079 @spacezoo5079 1 year ago It helps that this guy is 53 but looks like he's in his mid 30s with a 20 year old's skin Reply @Kikwatz @Kikwatz 1 year ago Why does this intro and everything else (even the profile pic) reminds me of another science based podcast...? 🤔 2 Reply @Dante-lv6vz @Dante-lv6vz 1 year ago ❤️❤️❤️ Reply @djeisonivanovich6311 @djeisonivanovich6311 1 year ago люблю тебья мужик. Reply @marcoelia4401 @marcoelia4401 1 year ago I would like to know how much longer mouses under your Age reversal protocol live Reply @ravigujju1780 @ravigujju1780 11 months ago Humans created there own problems with desires for that desire humans getting stress,if there is no desires ,humans not get age so fast Reply @daddyelon4577 @daddyelon4577 1 year ago PLS BRING MANUEL SERRANO TO THE PODCAST!!!! 1 Reply @behuman374 @behuman374 1 year ago (edited) You are look young for your age 52 , I was think you are 44,45 old, But you look great 😀👍 1 Reply @emilferent @emilferent 1 year ago Note of warning regarding mTOR: humans are not big mice, nor big flies. Don't know about Matthew though, he argues to the opposite @21:09 :) This research on mice suggests, at MOST, that we should do some research in that - hopefully - right direction. Reply 3 replies @davidurciuoli8594 @davidurciuoli8594 11 months ago (edited) What will we do with more people on this planet? Reply 1 reply @ainsleyameerali7622 @ainsleyameerali7622 1 year ago Dam right... sin clair is de bomb .... 1 Reply @hklilly4854 @hklilly4854 1 year ago So this is messing up my retirement planning… Reply @deborahbehr3910 @deborahbehr3910 1 year ago (edited) Yes, I want to do a cheek swab. Get going! Woot woot Where do we get the DHEA, Metformin and GF??? Reply @karenmiller6131 @karenmiller6131 1 year ago So excited :D Big Hugs Reply @rosamoreno4794 @rosamoreno4794 1 year ago Can you figure out womens thinning hair and hair loss. My crown is thinning and my hair part is widening and you see the small tiny broken hairs. 1 Reply @ronggowuniong7502 @ronggowuniong7502 1 year ago Thanks Doc. But to be precise. In test all scientist accelerate the agin in mice , then it ia easy to revert. But the real things ia much diffent 2 Reply @goodphone156 @goodphone156 1 year ago The problem is this kit of insider traker is expensive. Reply @guranajarhead @guranajarhead 1 year ago Finally! Reply @onpointglobal1828 @onpointglobal1828 1 year ago I think its great. But my suspetion is this .' people steadily losing trust in Symptom drug scam or health profuteering ' so he attempts to unwind the mistrust 1 Reply @susanabeatrizkober610 @susanabeatrizkober610 1 year ago (edited) No mater what You can avoid deth. 😂😂😂😂😂😂 Reply @califmike2003 @califmike2003 1 year ago Simple we age cause of SIN 1 Reply @joecoffee7750 @joecoffee7750 1 year ago Amazing Reply @EmmaDee @EmmaDee 1 year ago I love David!! He’s my boyfriend!! 😂😂😅 Reply @mrala @mrala 1 year ago Just keep going Reply @FruitTreeForest @FruitTreeForest 1 year ago Nice!! Reply @MinhVu-fo6hd @MinhVu-fo6hd 1 year ago This is again another evidence that Einstein is right. Time is relative. Reply @tpwb5882 @tpwb5882 1 year ago 🙏🏽🙏🏽🙏🏽🙏🏽🙏🏽🙏🏽👌🏽👌🏽👌🏽🙆🏽‍♂️🙆🏽‍♂️🙆🏽‍♂️❤️❤️❤️ Reply @kasiabiniek6701 @kasiabiniek6701 1 year ago exciting !! Reply @kyrregrtan993 @kyrregrtan993 1 year ago We age to fight cancer! 2 Reply 2 replies @provlaxswag @provlaxswag 1 year ago WOOOOOOO BEEN WAITING FOR THIS BABY Reply @carl8790 @carl8790 6 months ago Meh, I'm still skeptical about all of this 'reverse aging' stuff. I don't have anything to disprove what he's stating, but this all sounds like a very clever sales pitch for some product(s) that may or may not work. Reply @Inconceivable-pb5hc @Inconceivable-pb5hc 1 year ago From 30:20 to 30:35 will blow you away! You'll be screaming "WHAAAAAT"? Reply @MountainwithaView @MountainwithaView 1 year ago Dr. Berg..Dr. Bergman...Barbara O'Neil....all three have simular ideas & research... Reply @tessacyclone6329 @tessacyclone6329 1 year ago And what if over time people become metformin resistant qnd resistant to the other drugs as they go back a year ? And does not dying really chnage the history for "humanity " I see humanity ad connection between people and not the individuals lifespan ..... Reply @uptownszn376 @uptownszn376 1 year ago (edited) And your like the caveman that pushes me 😂 1 Reply @jpaulson5811 @jpaulson5811 1 year ago If you need a lab rat 🐀 ✋ 2 Reply @RunToTheHills999 @RunToTheHills999 1 year ago Amazing 1 Reply @JesusGanga @JesusGanga 1 year ago Amazing 1 Reply @jlholistictravelenespanol3429 @jlholistictravelenespanol3429 1 year ago Amazing 1 Reply @fgnsdfnbnd @fgnsdfnbnd 1 year ago A!C chart based on DCCT says diabetes is A1C= 7.1 % and prediabetes at A1C= 6.4%. Also A1C vs mortality is a j-shaped curve. Too low and tis not good either. 1 Reply @ConspiracyCraftersStudio @ConspiracyCraftersStudio 1 year ago How to get metformin without prescription? 1 Reply @alik2003 @alik2003 1 year ago amazing 1 Reply @user-hl3pv7ct1w @user-hl3pv7ct1w 1 year ago (edited) Can you keep a mouse alive forever ? No. Till then - stop the wild claims. 1 Reply @conniehudson4764 @conniehudson4764 1 year ago Conceptually I like the format (cohost who is pretending to anticipate questions that your listeners may have). It was actually helpful, “but” he was taking up too much space in my opinion. I like him, but this is your show and it was too much him. Again, I generally liked the format and your cohost, but felt he was a little too extra. A bit distracting. Reply @tempname882 @tempname882 1 year ago lol - why say you're taking AG for years? when you don't bro - you laughed at the thought of you drinking it daily. Reply @sonyjumper111 @sonyjumper111 1 year ago In the Intro he claims to be independent and does not want to sell anything. Just followed by mentioning sponsor that he also is invested in.. seems to be biased 1 Reply @aselaptl @aselaptl 1 year ago thank you 2 Reply @richardprice9730 @richardprice9730 1 year ago (edited) Intelligent or obsessional bordering on ..I think everyone can see there us something really odd going on . What I'm hearing David doesn't make sense, it would of course be great to live a long time if we remained fully functional speaking as someone whose sustained injuries insults and trauma thus is or remains a real struggle and for me a point of difficulty acceptance and a real desire for healing . But i cannot help but stop you on the dementia alzheimers point are you saying that you're family gas a generic predisposition to this condition ,you use words oike confusion reoeatedly and even your obsession about longevity seems it may have something to do with this ? If so then please be more open as for the joke you take to heart we are not that fisimilar to bananas seems to be bordering on the absurd ,like you can momentarily see it have a flash of insight and laugh can see your mad obsession for what it actually is ,just that ! but you just can't let it go ,I suggest changing tack to helping peopke like me who desperately need innovation in medicine and regenerationn as for ageing as a disease umm, smacks of 2 D thinking again the earthe is flat and that is scientism ,on step away from other forms of fanaticism ,well of course the Nazis would have lapped it up, but behind it i sense a frightened ..little boy who cant face his bodies mortality ,a narcissus who dreams of eternal youth ,terrified of deathe or maybe just felt tremendous confusion and abandonment as a child ,please lets look within David and drop the obsession ,Christ knows your wife ,kids abd even friends must be f..sick of it hah.. GOD Bless 1 Reply @happysimonrelax @happysimonrelax 1 year ago Great Reply @aimandjulian3195 @aimandjulian3195 1 year ago Great Reply @matkagrogan5251 @matkagrogan5251 1 year ago But vinyl and tapes that are analogue sound much better than digital cd :) Reply @maryannsinopoli1751 @maryannsinopoli1751 10 months ago And what about rejuvenation of elders teeth, you have not addressed that issue. Staying young, will teeth be as before at when youthful? Weird to have young everything but old enamel tooth and structure! Reply @neverever1063 @neverever1063 1 year ago ❤️ 7 more to go ❤️ Reply @SladkaPritomnost @SladkaPritomnost 1 year ago Bats that can fly live up to 40 years compare it to mouse :) Reply @joost1183 @joost1183 1 year ago Why does the western world need a prescription for metformine? Reply @aadwahwaba363 @aadwahwaba363 1 year ago Must have Bret Weinstein on this podcast Reply @kaylabryson1932 @kaylabryson1932 1 year ago He’s running a research lab that sells services… he’s saying he isn’t selling anything … shady and his past ??? Very shady !! Reply @TilveranWrites @TilveranWrites 1 year ago note to self: 48:18 Reply @alexmartian3972 @alexmartian3972 1 year ago This tone and voice during mentioning sponsors - is it so detached on purpose? Although I felt some emotions when David mentioned he has some role in the company. And one factual mistake already 10:22 - they have not talked about glucose as podcasts have only started. Reply @nikolajkapa2283 @nikolajkapa2283 1 year ago I woudnt want to live for 1000 years. World is too cynical, cold and greedy. So I have become partially. 1 Reply @sunnyc8679 @sunnyc8679 1 year ago The whale was still living when they pulled it out of the whale! Well I think they whaled it but... Reply @FlipVizor @FlipVizor 1 year ago Woo! Go Utah State University! 1 Reply @benderc.moriarti3419 @benderc.moriarti3419 1 year ago He seems so akward as a host.... ...which means he is not a entretainer. I trust him. Reply @onpointglobal1828 @onpointglobal1828 1 year ago In fact he pushes metforming for longivity? As easyly done by fasting. Harward got F f in ethics rin a survy for pimping for big pharma last year .by its own student survey. 1 Reply @ShinobiVuDU @ShinobiVuDU 1 year ago FUCK YEAH! Reply @Pawel27ok @Pawel27ok 1 year ago What the writer takes, because he doesn’t look great 😂 Reply @mojshar7382 @mojshar7382 1 year ago (edited) mTOR, AMPK, sir2in! Reply @georgepilarski1099 @georgepilarski1099 1 year ago aging comes from programming also u can become breatherian and pave the way to physical immortality Reply @firstlast5322 @firstlast5322 1 year ago 🖤 Reply @ricardolopez2903 @ricardolopez2903 1 year ago Lol “as we’ve mentioned on the podcast” Reply @hellobeautiful3301 @hellobeautiful3301 1 year ago Love you Dr Sinclair, but too much botox doesn't look good on you. You look good enough without it! 1 Reply @MeditationStationisHere @MeditationStationisHere 1 year ago 19:44 that whale story blew my mind Reply @timbo8366 @timbo8366 1 year ago Really got the YouTube script down, mentioning interesting things and then saying you’ll talk about it later. Reply @animus4967 @animus4967 1 year ago You said you're not selling supplements at the beginning, and then you sell us athletic greens which are supplements...? Reply @googlespies @googlespies 1 year ago David takes statins and metformin while telling us he's serious about anti-aging. Meanwhile both of those shorten one's healthspan/lifespan lol. 2 Reply 10 replies @kantautam4995 @kantautam4995 1 year ago Please anyone tell in simple words what to do Reply @richmorrow8750 @richmorrow8750 1 year ago Too bad he doesn't tell the ENTIRE truth --- ie: not all people do well on vegetables (cooked or raw) there is a subset of people who cannot digest them. 1 Reply @annafedyanovich6667 @annafedyanovich6667 1 year ago When you mentioned Jesus doesn it mean you are a believer? Can a believer be an objective scientist? 1 Reply @corporesano4437 @corporesano4437 1 year ago What is your biological age ?! Reply @hugex9796 @hugex9796 1 year ago I hate living in 3rd world so much. No good supplements here :(( Reply @dmmentopa5754 @dmmentopa5754 8 months ago How about us who belong to poverty line and no money to buy those product any remedies? Reply @archiekilmor @archiekilmor 1 year ago When you're doing Human Trials, let me know. Reply @kathrynoneill5862 @kathrynoneill5862 1 year ago I learned about him from Joe Rogan. Reply @bravorevolutionary9654 @bravorevolutionary9654 1 year ago Finally 1 Reply @LookingAway359 @LookingAway359 1 year ago Shoutout to USU. 1 Reply @GabrielaHandalArt @GabrielaHandalArt 1 year ago "*You're* not so different from a banana" haahahaha Reply @mikea1094 @mikea1094 1 year ago How long do you need to fast? Reply @intellectualpupil @intellectualpupil 1 year ago David looks 28 1 Reply @ioma6 @ioma6 1 year ago HOW CAN I GET -M E T F O R M I N - if I m not diabetic ? Reply @edwardhachetl7141 @edwardhachetl7141 5 days ago It's amazing what David and scientist are discovering but they just discovered what was written in the Bible 3500 years ago. Bible clearly says that humans were created to live forever young in paradise on this Earth, that's why Creator created endless universe for people living endless lives. And this will happen not because of human efforts but Almighty himself will fix human body, remove all doning evil and restore paradise on the Earth. Reply @aaliyahlee1265 @aaliyahlee1265 1 year ago I only know one product that my overall health can rely the most. It's NMN by Vitruvin Health. Cost-effective! 1 Reply 1 reply @laurinhamilton1016 @laurinhamilton1016 1 year ago In triplicate.... I wonder what the co hosts background is🧐. Reply @ctube221 @ctube221 1 year ago I've been eating second breakfasts's this whole f*****g time! Reply @PraneethAvasarala @PraneethAvasarala 10 months ago (edited) 26:45 Wow. Reply @BoninBrighton @BoninBrighton 1 year ago You use the word ‘book’ multiple times in the first few minutes… I’m triggered into counting …. this is now ‘Book’ bingo, you too can play! 1 Reply @flip2724 @flip2724 1 year ago 31:02 he just snaps his finger and keeps talking lmao Reply @tgifford4 @tgifford4 1 year ago Healthspan. Reply @eljah7585 @eljah7585 1 year ago Semen retention is another longevity practice. Species that sex less live longer. 1 Reply @nina-xw6ku @nina-xw6ku 1 year ago Happy New Year 1 Reply @marzevd @marzevd 1 year ago you just said you don't sell supplements then advertise supplements??? 1 Reply @dodutra @dodutra 1 year ago How old are you Doc? Reply @mathsciencefancier @mathsciencefancier 1 year ago (edited) Hi, Dr.Sinclare. How about inventing a smart toilet with me? I'm trying to service curating customized heath-statistics-report for every earthians(everyone who live on our earth) based on their every excrement. This will help improve and develop humankind's health and youth and medicine field based on proof, evidences and data. Reply @sandra8542 @sandra8542 1 year ago (edited) level test is only for Americans, what about Canadians :(((((((( Reply @friend22 @friend22 1 year ago God Lord Time Reply @acrosinus @acrosinus 1 year ago If we have all these magnificent pathways existing to slow down aging why arent they turned on for all the time? It does not make sense from evolutionary ecology point of view. Is there an actual fundamental trade off between eating a stake and staying young? 1 Reply @raynabozny2338 @raynabozny2338 1 year ago David it's The MICROBIOME Reply @stendaalcartography3436 @stendaalcartography3436 1 year ago Asian person watching, then 20:36, whoa whoa buddy 0 to 100 real quick there. shots fired XD Reply @Matt-bz5vg @Matt-bz5vg 1 year ago ........I don't mean to be rude but honestly this would've been a much better podcast with David just doing this alone. The dude on there with him isn't keeping the conversation on track, he interjects with stupid annoying comments. The first half of the podcast it sounded if his goal was to make people believe slowing aging is possible. Just give me info, I'm here because obviously I already believe it's possible to slow/maybe stop aging. The arguments were stupid too, like well yeah we are similar to bananas, whales, mice, etc.......stupid argument yeah we have a decent amount in common but the differences fckn matter. Men and women are pretty fckn similar but I promise the differences fckn matter. Anyways rant over, I'm super stoked though to be able to hear more from David. Great info overall 1 Reply @jimmock1155 @jimmock1155 1 year ago You age because of sin. God’s perfect plan was for our bodies to live forever, but sin cut us off from Gods source of life. You will age. You will be diseased. Your body will die. Then the judgement. That’s what the Bible says. The person that animates your body will live forever, some with a new incorruptible body in the presence of God, and others will live eternally separated from God, eaten up with the regret of having spurned the Creator. It’s all in the Bible…..Ignore it at your peril. . 1 Reply @TheQuesoJC @TheQuesoJC 1 year ago 49:40 xD lmfao 1 Reply @leadimentoobrien1221 @leadimentoobrien1221 1 year ago Slow longetity would be a turtle. A whale is eating KRILL AND NO GRAVITY...... Reply @annafedyanovich6667 @annafedyanovich6667 1 year ago Predation? Sharks don't have it? Reply @PAWELMEDOWSKI @PAWELMEDOWSKI 1 year ago Andrew sent me here. No regrets Reply @provlaxswag @provlaxswag 1 year ago YESSS SIRRRRRRRR Reply @armandsant1143 @armandsant1143 1 year ago and koi fish is over 100 years old hmm Reply @HolidayNova @HolidayNova 1 year ago called him a cave man lol Reply @rsulmena1579 @rsulmena1579 1 year ago thanks Reply @drippie1088 @drippie1088 1 year ago Couldn’t make it through the episode, the other guy keeps on interrupting my focus. 1 Reply @manumullen88 @manumullen88 1 year ago They are married, right!? 1 Reply @martyyuen @martyyuen 1 year ago What would this planet be like when the human population reaches a trillion? 1 Reply @cuongho0110 @cuongho0110 1 year ago (edited) Thanks 36:54 Reply @f.u.n5323 @f.u.n5323 1 year ago but like people is dying still 1 Reply @latentsea @latentsea 1 year ago This didn’t age at all... 1 Reply @levondarratt787 @levondarratt787 1 year ago 564 comments and no take aways and findings? They're all cowering in fear, lol. Reply @jimmock1155 @jimmock1155 1 year ago You age because of sin. God’s perfect plan was for our bodies to live forever, but sin cut us off from Gods source of life. You will age. You will be diseased. Your body will die. Then the judgement. That’s what the Bible says. The person that animates your body will live forever, some with a new incorruptible body in the presence of God, and others will live eternally separated from God, eaten up with the regret of having spurned the Creator. It’s all in the Bible…..Ignore it at your peril. . Reply @B33Ys @B33Ys 1 year ago why does he have such a sadistic look on his face? just me? Reply @shibbling @shibbling 1 year ago *adding a comment to this so the algo picks it up and more people see it* Reply @JolicoeurAbear @JolicoeurAbear 1 year ago can't find a doctor yet that will prescribe metformin, is berberine as good? Reply 1 reply @jflcreate @jflcreate 1 year ago I’ve seen numerous videos on aging, insulin control and fasting…this one by far is the longest and the most boring Reply @rocksteady6448 @rocksteady6448 1 year ago (edited) We age because of sin Reply @golddredgewater @golddredgewater 1 year ago We age because Adam and Eve sinned 6,000 years ago which took perfection away from mankind and we grow old and die. 2 Reply @freshcoatcustompaint8870 @freshcoatcustompaint8870 1 year ago Why do you and Huberman drop the same product plugs? 1 Reply @jamesfrith9869 @jamesfrith9869 1 year ago For the Alg boost Reply @pawelmichalowski7043 @pawelmichalowski7043 9 months ago 🤯 Reply @editelh @editelh 1 year ago It’s really a shame that these people are mainly driven by profit. The amount of ads in the middle of this presentation is pathetic. Shameful. Reply 4 replies @AZURRTIME @AZURRTIME 1 year ago Man wants to desapear. Reply @carloboyer @carloboyer 1 year ago (edited) 1:00:25 Reply @waindayoungthain2147 @waindayoungthain2147 10 months ago Nothing made your age sense whatsoever if’s you are not the stillness and not thinking about the progress! If’s cells are not aware of your biological and mindfulness strongly against your going with concern seriously on the better ways for the citizens of the world🌎. Reply @stefanswede285 @stefanswede285 1 year ago Dr Sinclair promoting drinks, test??? to me he lost his integrity. looks even ashamed when he reads the advertisement 1 Reply @dominikd9834 @dominikd9834 1 year ago Lets all live forever, fuck yeeeaea Reply @catscanmeow @catscanmeow 1 year ago Isnt it insincere to use botox if youre espousing anti aging stuff, people might get a false idea. Your forehead and eyebrows barely move. Reply @irobu @irobu 1 year ago We age bc of of Adam n Eve.....NOT Adam M Steve! 1 Reply @TheVanityJunkie @TheVanityJunkie 1 year ago Pros and cons about preventing ageing and longer lifespan, what are we gonna do if we all love up to 120 or 150??!! The planet is going to be so overpopulated, it already is !! 1 Reply @Jay-rp5rg @Jay-rp5rg 1 year ago I feel like Matthew LaPlante just comes off as fake interested. It feels disingenuous and loses my trust Reply @deepdoubtsboutu6898 @deepdoubtsboutu6898 1 year ago Athletic Greens not a supplement ? Comments deleted ? 1 Reply @adamm5079 @adamm5079 1 year ago Daviiiiid! Lets g0000000 Reply @Estrav.Krastvich @Estrav.Krastvich 1 year ago (edited) Cosmic speech) 1 Reply @tnntlmmn277 @tnntlmmn277 1 year ago super interesting. let's hope the boomers don't hear about this. Reply @sibusisozikalala6783 @sibusisozikalala6783 1 year ago Veritasium brought me here. Reply @BestofUsInvestors @BestofUsInvestors 1 year ago Lifespan changed the direction of my life. My Youtube Channel, Best of Us Investors is built on this science. Reply @TheVietnameseDevil @TheVietnameseDevil 6 months ago 🔼 Reply @BlackMamba-lt8oe @BlackMamba-lt8oe 1 year ago do trials in chimpanzee not mice Reply @dubiouspuinous4722 @dubiouspuinous4722 1 year ago 35:15 Reply @gissie391 @gissie391 1 year ago We age because of Adam eves sin because we tbey died when they ate fruit from tree try to understand before you dismiss it. Reply @bashaarsaadeh @bashaarsaadeh 4 months ago Hi guys, I’m from future Reply @cdal1315 @cdal1315 10 months ago big thumbs down because of how many ads were put into this video..makes great content unbearable to watch smoothly 👎🏼 2 Reply @deepdoubtsboutu6898 @deepdoubtsboutu6898 1 year ago (edited) Im sure your hearts in the right place but there is cash being made through sponsers and arent you working towards medications ? Non Profit ? Got your book , just havent had time yet . Looks extremely interesting . I dont have a problem with you marketing stuff but bit of a Biblical contradiction to say your not pushing Supplements and making money and then going straight into 3 adverts to the contrary two of which you work for ? I know youre clever and theres lots of Cavemen out there but were probably not as stupis as you might think ? 1 Reply @WFNOIR @WFNOIR 10 months ago GOOD ads david :v Reply @rosisunny9302 @rosisunny9302 1 year ago 😲😲😢😢🤷‍♀️🤷‍♀️🤷‍♀️You don’t come to the Point,and ad so much personal Stories,the name off the vid. is misleading Reply @anandragnauth5565 @anandragnauth5565 1 year ago Please dont waste any more medication on rats, im a willing 42 year old male specimen....please contact me. 1 Reply @cholakicha @cholakicha 1 year ago 35:00 1 Reply @warrenwelch6295 @warrenwelch6295 1 year ago wen next episode Reply @bossdeman @bossdeman 1 year ago Dr Sinclair is brilliant but not funny.. 1 Reply @ecobra169 @ecobra169 1 year ago Drugs, drugs, drugs. None sense. Reply @onpointglobal1828 @onpointglobal1828 1 year ago I loved it . But By for profit med can.t eliminate sickness. No diseae no mega wealth like a car dealer push public transport. Fishy 1 Reply @peterdelevoryas4684 @peterdelevoryas4684 1 year ago Get rid of the cohost Reply @sgg3745 @sgg3745 1 year ago Not all that interestingly presented 2 Reply @alexsoto939 @alexsoto939 1 year ago Whats with his eyes 1 Reply @jasonzhao3222 @jasonzhao3222 1 year ago I was here Reply @burtnation1357 @burtnation1357 1 year ago ♿️♿️♿️ Reply @DungTrinhMD @DungTrinhMD 1 year ago Whack a mole medicine ! Reply @danielcarter491 @danielcarter491 4 months ago My personal opinion is that this man is somewhat of a fraud. Please do some research on this man before you treat him as some kind of messiah. Reply @maxb5957 @maxb5957 1 year ago Max was here Reply @1DemocraticMatch @1DemocraticMatch 1 year ago (edited) The sponsor bit at the beginning ruins the credibility ... sorry David - LOVE you and your work, but it makes this look like an infomercial to any new eyes to your work ... yuk. AT LEAST put it at the end, and have someone else read it 1 Reply 2 replies @lenacrang4025 @lenacrang4025 1 year ago A.I. is the wrong pathway - god have mercy on us all - suffering the medical system today is not possible - 2030 is the year Reply @lummy7774 @lummy7774 1 year ago is it me or i am the only one who thinks LaPlante is not in the right place. it`a annoying and funny and talks too much. man let the brain in the room talk. i am sad that he is in all the podcasts. Reply @sanatsrivastava2814 @sanatsrivastava2814 1 year ago What the fuck. This dude literally ripped off Huberman's style of podcast. Get original, doc. 1 Reply @streetmodes @streetmodes 1 year ago Lovely? who's gay? Reply @sloughkey @sloughkey 1 year ago Enqi been saying Reply @drippie1088 What to Eat & When to Eat for Longevity | Lifespan with Dr. David Sinclair Podcast Episodes #2 Jan 12, 2022 In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss how frequently we should eat, what food we should avoid, and what food we should pursue. They discuss the science behind how a "low energy state," which can be induced by a period of fasting, combats aging and promotes health. They also walk through research that points to the benefits of a mostly plant-based diet for slowing aging and offer key insights into when to eat and what to eat to maximize longevity. #Food #DavidSinclair #Longevity Thank you to our sponsors: Levels - https://levels.link/sinclair Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsincla... Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclai... Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante Timestamps: 00:00:00 Introducing Episode Two: What to Eat & When to Eat for Longevity 00:01:10 Thanking the Sponsors 00:04:36 A Starting Place for Longevity: Eat Less Often 00:08:04 Caloric Restriction is an Evolutionarily Conserved Anti-Aging Strategy 00:09:52 Dietary Longevity Strategies are Accessible (and Save Money) 00:11:39 A Low Energy State Triggers a Genetic Pathway Involving Sirtuin Activation 00:13:10 NAD+ is Elevated by a Low Energy State 00:15:23 Fasting, mTOR, and AMPK 00:17:37 Data in Humans vs. Model Organisms 00:21:24 Evidence that Fasting is a Pro-longevity Intervention in Humans 00:24:00 Evidence that Fasting can Attenuate Human Disease 00:25:11 Different Fasting Regimens 00:29:42 Focus on Time-restricted Feeding (≥ 16 Hours of Fasting) 00:33:26 Continuous Glucose Monitors 00:34:24 Genetics Influence How an Intervention Affects Aging 00:36:51 A Trick for Fasting: Filling your Body with Fluids 00:38:44 Intermittent Fasting with Adequate Nutrition (IFAN) 00:40:00 Things to Avoid: Excess Sugar and Protein 00:45:16 Branched Amino Acids, Red Meat, and mTOR 00:47:53 Plant-Based Diets Protect Against Aging 00:51:44 The Okinawa Diet and Blue Zones 00:54:16 Xenohormesis 00:58:16 Main Takeaways 01:04:12 Obesity, Eating Habits, and Aging 1:05:54 Metabolic Winter Hypothesis 01:06:44 Preview for Episode 3: Beneficial Stress 01:07:23 Options for Subscription and Support Links: Dietary restriction extends lifespan in dogs - https://bit.ly/3FlDo4y Intermittent fasting in patients with metabolic syndrome - https://go.nature.com/3FggKKZ Alternate day fasting in healthy, non-obese humans - https://bit.ly/3HXGptH Time-restricted feeding in humans with prediabetes - https://bit.ly/3ffZWct A 24-hour fast reduces inflammasome activation in humans - https://bit.ly/3fwDc8t Fasting and diabetes - https://bit.ly/3rdtRHQ Intermittent energy restriction and multiple sclerosis - https://bit.ly/3HV7i1o A fasting-mimicking diet in patients with breast cancer - https://go.nature.com/3flcbV2 Mouse genetics influence how diet affects lifespan - https://bit.ly/3qiBc9R Vegetarian dietary patterns and human mortality - https://bit.ly/31OCtMq A Mediterranean diet slows biological aging - https://bit.ly/3I1rcbd Plant polyphenols regulate lifespan in yeast - https://go.nature.com/3HWWGiB A Mediterranean diet is linked to reduced mortality - https://bit.ly/3fdDPDx Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. Chapters View all Explore the podcast 8 episodes Podcast Episodes David Sinclair Podcasts David Sinclair 299K subscribers Videos About 3,897 Comments rongmaw lin Add a comment... @teeqo @teeqo 1 year ago Fantastic episode! Thank you, thank you, thank you! 🙏🏼 100 Reply 2 replies @ConnectWithUganda @ConnectWithUganda 8 months ago This podcast makes me know that there are people that genuinely care about humanity and want to see us all living, we’re fortunate to be able to watch this for free, I will definitely support the sponsors of this podcast, blessings in all your work 🙏🏻 78 Reply @maserin1 @maserin1 1 year ago I got introduced to David Sinclair through the Lex Fridman podcast and was impressed with his insights on health and nutrition. Looked up this podcast, listened to this episode, and immediately started a 20/4 fasting regimen which became an 18/6 regimen after about two weeks. After about a month and a half of consistently eating this way, I have dropped 3 inches in my waist and now fit into a pair of jeans I wasn’t able to wear since before the pandemic. My skin has cleared up from all the extra water intake, my energy levels have evened out, my ability to focus has skyrocketed, my severe bloating issues have disappeared, my keratosis pilaris has gone away, there are no more puffy bags under my eyes, and my mood has significantly lifted because of the increased confidence from all of the above. I just turned 40 and feel and look like I did in my 20’s. You truly saved my life, Dr. Sinclair! I will never stop eating this way. 64 Reply 3 replies @LJ-mc3rv @LJ-mc3rv 1 year ago He says he eats one meal a day and he shed his weight and got his 20-year-old body back. This is what happened to me. I am 70. I was getting obese. I heard of intermittent fasting and said: what the heck. so coffee for breakfast and then I ate whatever I wanted once a day. It could be ice cream, pizza, whatever. And if I was starving I had a handful of raisins or a cup of tea with honey. Not only did the weight come off, but my whole figure returned. I had no flab. I did no do exercise. I happened to go to the doctor for something and he said he never saw anyone my age so healthy. So this is all true. Shocking. I've gained some weight due to being a bit depressed over world events, but when Spring comes I'll start again. I do have a dog, so I do walk a lot, and climb stairs. Try it. It is fantastic. 487 Reply 41 replies @audriusurbonavicius5428 @audriusurbonavicius5428 2 months ago We need more of these podcasts. Maybe Q&A. It would be very interesting to find out if Dr. David Sinclair has done any research on some of "longevity foods" like: dark chocolate, honey (it is thought that bee keepers always live long), nuts, beans, mushrooms, garlic. turmeric, cinnamon. Also how to bridge between "eat less often" and well known "eat 5 servings of fruits or vegetables a day"? Witing for new podcast Q&A_001 🙂 4 Reply @RoedhamHouseRanch @RoedhamHouseRanch 1 year ago This was absolutely EXCELLENT!! At almost 62 and watching co-workers & friends who are around my age, pass away from various causes (often age related illnesses) has really alerted me to my own health and mortality. I don't want to succumb to illnesses or to die young. Nor do I want to age and be sick throughout those last years....for myself or for my family to watch me suffer. Dr Sinclair...bless you for sharing your knowledge, your insights, your recommendations and for showing us, that regardless of our stage/age in life, we can help ourselves. 😊 💞 88 Reply 2 replies @juanpabloaranovich5619 @juanpabloaranovich5619 1 year ago This was a fantastic episode. Just sharing my notes here. Main takeaways: 1- Eat less often. 2- Avoid sugary drinks and foods. 3- Reduce meat intake for longevity. 4- Its never too late for dietary changes. 5- Find veggies that have been stressed out (organic, colorful veggies) 6-Never start a meal with sugars, if you do eat them at last (desert). EAT LESS OFTEN -There is a genetic pathway that gets triggered by low energy. These genes (sirtuins) respond to low energy (low glucose levels-caloric restriction), high heat, low amino acids, high salt (stressors). -----They take care of the DNA repair and the stabilization of the epigenome. -When the body is hungry, the body makes NAD (fuel for the sirtuins). -Two ways to activate sirtuins synthetically: 1) Use some molecules 2) NAD booster. Longevity genes: Mtor: protein that registers amino acids. Allows the cell to build things. Not a recipe for longevity. Activates autophagy. Ampk: goes up when hungry. Makes more mitochondria (important for making energy) Sirtuins Fasting: - Metformin: mimics fasting. - Time Restricted Feeding: At least 16 hours. - Liver compensates for the lack of food. Glucose neo-genesis. It overcomes the feeling of hunger. The liver starts making glucose at a steady level. Sugar: big killer. It spikes glucose. Glucose shut down sirtuins and ampk. Defenses against diseases and aging shut down. Protein: we should avoid high protein red meat diet for longevity. It inhibits mtor. Amino acids: three important. Leucine, isoleucine, and valine: BCAAs. Are used to sense protein intake. The sensor is mtor. The mtor activates when you get them. Mtor repairs and build muscle. In the short run, this is good for building muscle etc. But in the long run, mtor is the responsible for autophagy, which is key to longevity. Plant based diets: the more vegetarian you are, the longer you live. The best, Okinawa diet, is plant base diet with fish - (probably because of Essential fatty acids) Humans grew COLD and HUNGRY. Now we live at warm houses with food available all the time. Let me know if you want me to keep posting these notes, I am on Twitter @juampiaranovich 3.9K Reply 282 replies @DianasMurals @DianasMurals 6 months ago I’ve been following this protocol for almost 30 years. I look and feel decades younger. I’m perfectly healthy. Thank you for sharing this incredible information. Would love to learn more about adding the right supplements to my life. 10 Reply @belladonna1821 @belladonna1821 1 month ago Fantastic! I'm aggressive about living longer and am so glad I found your book and the podcasts! I feel hope for the first time. Also, love that you are bringing the information directly to us! Please never stop! 1 Reply @artful_spinning2319 @artful_spinning2319 1 year ago Love listening to David...so wise and not arrogant. This is such a wealth of information, thank you! Fasting while maintaining nutrition is really the best way to improve many things, I have experienced first hand for myself! My red wine consumption isn't moderate like it should be but working on that :-) 40 Reply @ashleyhorton4747 @ashleyhorton4747 1 year ago Thank you so much for these videos! I really appreciate educators, scientists, and doctors that make their knowledge accessible to the general population. The science you present has changed my life. 9 Reply @StacyPaulsen @StacyPaulsen 9 months ago This is an amazing episode and has helped me combine smart supplements and fasting in an easy-to-see-results way for my coaching practice. Thank you... once again!! 1 Reply @ShaunPeterKelly @ShaunPeterKelly 1 year ago (edited) One of the best podcasts about living a long healthy life I’ve seen. I'm 84 and wish food scientist's had found this fasting protocol years ago. I do a 24 hour fast once a week and I feel wonderful. Anyway I can see a future where obesity will be a thing of the past but sadly not in my lifetime. Good luck to all you wonderful healthy people. 190 Reply 16 replies @christinesprague2845 @christinesprague2845 6 months ago (edited) Love these podcasts. So much of what you talk about has been around for a long time. So thankful you are doing these experiments to bring validity to this lifestyle, like Ann Wigmores story and health journey. Really think it is interesting talking about plants being stressed. When you garden keeping your plants in the greenhouse makes them weak because the don't have any stress and sometimes you notice they don't do as well when you plant outside. For example Okra never does well unless planted outside in garden, we get 10 feet tall plants, everytime you pick okra it stresses it and it grows taller and taller. Reply @bentrider @bentrider 1 year ago I have experimented personally with fasting and just daily caloric restriction. Both have produced great results. I think what it comes down to is which one can be done for a lifetime. Personally, I have been able to do caloric restriction for much longer periods of time than I could with any type of fasting. 2 Reply @rdtradecraft @rdtradecraft 1 year ago When I started intermittent fasting, three weeks ago. I decided I'd be able to do the 8:16 approach, and a bunch of friends and I all started trying this at the same time(mutual support). Unlike my friends, I assumed I was in for a rough three or four days as I got used to the hunger periods. I was right. I got headaches, had very low energy, and honestly felt a little sick at times the first day. Fortunately I started at the beginning of 2 days off from work, so I wrote off that first day. By the second day, I felt a good bit better, though still was bothered by the hunger pangs. By the third day, I felt "normal" and have felt less and less hungry, even though I was not eating as many calories. I have also been eating better without really trying. Don't know if that's a benefit of fasting or I'm just paying more attention than I used to. Now I am eating far less than I used to and not feeling at all hungry until just before feeding time. 32 Reply 2 replies @78Wedin @78Wedin 1 year ago I just want to thank you gentleman. As a parent who is newly looking to transform the health of myself and my daughter, I am overwhelmed with gratitude for the information shared here. Definitely subscribed and look forward to what else I learn her. Truly, thank you so much! 3 Reply @masiiharwood6082 @masiiharwood6082 1 year ago Thanks very much for such an informative and enlightening conversation, you guys are great souls ❤ ♥ 6 Reply @wasimahmad934 @wasimahmad934 1 year ago I am a biology teacher. I have used many of these protocols on myself. It blows my mind to listen to the scientific research that is going on in this regard. I would definitely share this info with my students. Great work Dr Sinclair. Hats off 1.2K Reply 122 replies @leonardoparedes9823 @leonardoparedes9823 1 year ago I have been doing what this guy says for the past 3 years + without even knowing about his existence, found him out in Andrew Hubberman's podcast. I eat once a day (giving at least 16 hrs of fast) and fast once a week 24 hrs and sometimes for longer. I used to be always sick and tired all the time since kid. It's been 3 years + I don't get sick, I did a full blood and hormonal pack exam test and all my stats are on the optimal spectrum, my testosterone is at its peak and I feel great, full of energy and mind clear. I'm basically watching his videos and learning more + confirming what I discovered by trial and error by myself and I trust 100% this man is correct. I'll die fasting, restricting calories and avoid processed shit. There are entire industries draining people's mental and physical health but thankfully I got out of this and we have blessed people like this guy to come out and publicly provide the population with this life changing knowledge. Success for you Dr. David. 26 Reply 5 replies @francescalevine8735 @francescalevine8735 10 months ago I love that Dr. Sinclair is not afraid to put the information that we have out there for people to decide how to proceed. Many doctors are too scared to try anything unless it is 100%proven and like he said by that point we’ll be dead. 2 Reply @connieacevedo4709 @connieacevedo4709 10 months ago Thank you for this episode, I have gained so much information on how fasting helps in longevity. I fast 19- 20 hrs. and this was very informative. 4 Reply @hehasrisen1990 @hehasrisen1990 7 months ago Great information, I’m working on reducing my sugar intake in latte’s and sweets… I already drink tea to help skip a meal or instead of snacking… I literally watched this whole thing. What a wealth of knowledge 👏🏻👏🏻👏🏻 2 Reply @SeviYoga @SeviYoga 11 months ago David Sinclair is so awesome! I love his sense of humor besides all the research he's sharing! 7 Reply @sandradeterman8922 @sandradeterman8922 1 year ago Absolutely amazing, as always! David Sinclair is a genius, and he's literally changing our species for the better. So grateful 140 Reply 6 replies @captain687 @captain687 1 year ago I can confirm through my experience that fasting feels amazing once your body gets over and eventually overcomes hunger pains. 11 Reply @jjv1930 @jjv1930 11 months ago I love the discussion, very thought provoking. I would love to see a discussion with some of the promoters of high protein diets. I think there is so much information out there about what the best diet is and can be overwhelming. Discussions about different foods are amazing. Thanks you! 3 Reply 1 reply @jonparrott4081 @jonparrott4081 2 months ago (edited) I've always found that increasing the fasting times by no more than an hour or two at a time works for me really well...i can keep increasing to up to over 40+ hours at a time....fasting time length is like building a muscle, a strength. We take a dog for a walk to give it exercise. We also can benefit from giving ourselves exercise at the cellular level. Thats what i believe a big part of all of this is too. Make yourself tougher inside. Reply @es1653 @es1653 1 year ago Immeasurably helpful by an extremely knowledgeable doctor. Listening to Dr. Sinclair I am certain the dieting information is 100% correct. I'm a 24 hour snacker but will try to mend my ways starting today! I wish this material had existed at university years ago - I would have studied science. Thank you so much! 2 Reply 1 reply @DM-ms7pu @DM-ms7pu 1 year ago Quite interesting! This will probably change my life. I think many people are able to follow this anti-age program because we live in a time where some of us have options and food is there when we need it. When food is scarce or one must hunt to survive, fasting would be the last thing on my mind. 2 Reply @timbo8366 @timbo8366 1 year ago Dr. Sinclair is awesome. Besides all of the work he does, he takes the time to share it with the world🙏 132 Reply 3 replies @davidbanks2730 @davidbanks2730 1 year ago Very interesting. Thank you for making this available on YouTube. There is one thing that remains hazy to me, it's the recommended daily calorie intake. Your body has to "feel" hungry , but you still have to provide it with the necessary calories (whenever you choose to take them) to go through 24 hours and meet your energy needs. Surely you don't want to go below your BMR. So, how do you calculate this intake? Also, by reducing the number of meals to only one, you make it more difficult to cram into this unique meal all the variety of vitamins, minerals etc... you body requires, and you have to take supplements - as you do, in the mornings. You become highly dependent on these supplements. What happens if you suddenly don't have access to them, for a prolonged period of time? Do you revert to more meals per day , and does you body remember how to "extract" those elements from actual food? Take care 6 Reply @SilverFan21k @SilverFan21k 6 months ago Hello David, thanks for the great podcast series and youtube videos. I honestly didnt know it even existed until many months later. Better late than never! 👍 3 Reply @alisaber502 @alisaber502 1 year ago I am taking notes of everything you describe here. your words are really helpful. I wish everybody were excited to watch these episodes and take advantage of your words. As a geneticist I would love to work in your research team one day. 3 Reply 1 reply @KatJaguar1122 @KatJaguar1122 10 months ago Beautiful. I’m inspired to make further adjustments, based on my own needs and measurements. How awesome. I’ve moved through a number of dietary changes in my life-I’m 51 now. In my 20’s I was almost vegan except for butter and some cheese. Went Westin A Price at age 30. Paleo at age 40. IF and keto at age 45. Ate meat and eggs almost daily while doing keto. Dropped the keto 2 or 3 years ago, and my eating window not as wide. Now the gears are moving in my head about how best to move forward. 4 Reply @damlu5149 @damlu5149 1 year ago This is a piece of gold, thanks for your work. The only problem is the way the interview is driven, interrupting all the time and moving to the next subject without giving time to the doctor to elaborate the answer. It's stressful and it fragments the information 😩 12 Reply @noonecaresaboutgoogle3219 @noonecaresaboutgoogle3219 1 year ago I've always bounced in and out of exercising and eating well, taking my relatively healthy body for granted. Dr Sinclair's very easy to understand advice has given me the motivation to make permanent healthier habits for nutrition and lifestyle. Delaying aging by 8 or 10 years was the motivation I needed! 37 Reply @retiredbitjuggler3471 @retiredbitjuggler3471 4 days ago (edited) Wonderful presentation! I have been following a low carb Mediterranean style diet in combination with time restricted eating (limit my feeding window to 2-3 hours each day and will do a 72 hour fast on average around once a month). While it is a challenge to consume all my food in this window, I have worked it into a routine where I prepare and consume a large, very varied multi-colored vegetable salad supplemented with some nuts and seeds and a small amount of goat or sheep cheese in combination with whatever vegetables and proteins that my wife has prepared for dinner. I do apply a large amount of EVOO/vinegar with a combination of herbs and spices high in polyphenol content to my kickoff salad. I use a very high quality aged balsamic and a homemade apple cider vinegar. Some people find it repulsive, but I ferment my own apple cider vinegar mainly for the scoby and mother content (I do consume the minced up scoby in my salads). I will also include a can of anchovies or sardines 2 or 3 times a week. I realize that I am a cohort of 1, but my results in the past 18 months have been miraculous. I’ve lost almost 80 pounds, brought my A1C down from 8.9 to 5.4, eliminated what I had been describing as the aches and pains of getting older. To state it as short as I can — I feel younger now than I did 20 years ago. This is very doable. I’m not a zealot and do fall off while on vacation or dining out at or with friends. In those situations, I will consume whatever is placed before me. I do avoid sweets most of the time, but will enjoy celebratory confections (birthday, anniversary, wedding, …) out or superstition and/or respect. I never want to be put in a position where those around me get the feeling that I’m trying to shame anyone. I find that people become very interested in my journey and just maybe might be encouraged to experiment on their own. Case in point — beside close family and friends, I’ve gotten the attention of my GP, oncologist, surgeon, eye doctor, and the guy who has cut my hair for the past 40 years. They all spend most of our visits asking what changes I’ve made because of the dramatic health improvements I am experiencing. I am off all previous meds (diabetes, thyroid, hypertension), my hair is filling in, and my GP commented during my last visit that I should write a book if I manage to maintain my progress over the long haul. I simply chuckled at him and said “There are already hundreds of these books out there — we just have to get people to read them!” 😊😊😊 1 Reply @mind_in_repose_now1256 @mind_in_repose_now1256 5 months ago (edited) I am very thankful that I discovered fasting! I do OMAD 5 to 6 days a week. I’ve never felt so good. 1 Reply @Gabriel-MagicMusic @Gabriel-MagicMusic 3 weeks ago (edited) Great episode. I've understood all the things you can do to live longer. I am interested if the studies are focusing mainly on how to live longer or on how to live longer and have a good quality of life by doing things important to you? Probably it is easier to live longer if you have a simple relaxed life and just walk around and enjoy yourself, but what if you have to have a very active life : doing intellectual work in the mornings, doing intensive sports in the afternoons , social life...etc ...then how can you put all food in one meal, and all the other things focusing mainly on living longer??? So , is the research taking into consideration the diversity of professions and their needs to function at their best ? Reply @yourhomesoldguarenteedinbc @yourhomesoldguarenteedinbc 1 year ago When I first asked my friend who got me into fasting about being hungry, he said hunger is a feeling you can get comfortable with it. 22 Reply 2 replies @Spawn733 @Spawn733 1 year ago Thank you very much for the scientific articles and background for the research. I'd like to try all this about eating less often myself but I'd like to understand more of the details so I can adapt to it. Is there a more robust guide as to how to eat less often, and the best vs worse examples of how to bend that guidance as we transition? 1 Reply @angelica0269 @angelica0269 1 year ago (edited) I keep discovering that I had it right all along! Honestly this is how I have been eating and I was called a bad mom for not having sweet food laying around for my children and most days we would fast. We have never been sick. Now my children are all grownup man between the ages of 26-30 and once they left at age 18 to college they gained weight and ate terribly which affected their immune system but thankfully they are now getting back to what they learned while living at home. Our diet was basically like this: Monday-Friday we will have no breakfast, no snacks and eat a healthy lunch and a big heathy dinner and during the weekends we will have a big breakfast and a dinner and skip lunch. Great information in this channel! Love it 251 Reply 15 replies @obioraonunkwo2228 @obioraonunkwo2228 1 year ago Thank you so much, senor Sinclair. You really advance the cause of humanity in a meaningful way! 1 Reply @Richardsondx @Richardsondx 8 months ago Thank you for this. Very informational! I bought the book! Does whey protein have the same effect on aging as regular meat protein? I’d love to hear your take on that. 1 Reply @simonebrighina8262 @simonebrighina8262 6 months ago (edited) Hi, first of all thank you for this awesome podcast. I have two questions for @DavidSinclairPodcast - On Tuesday and Thrusday I go out for running in the morning and I skip breakfast, lunch is on 13.00-14.00 pm, so that I can have 16 hours of fasting. Due to the fact that I burn 600-1200 calories while running (obviously without having any breakfast), and I only use my internal glucose supply to create energy, can I consider that my fasting and autophagia effects are improved by the exercise? Do 16 hours that way may is like to do 18h or 20h of fasting? - On Monday, Wednesday, Friday I do Gym (natural body building) in the morning, with focus on muscle growth. I assume that I cannot do fasting because I need to eat proteins/amino acids to rebuild muscles after the training. In case I decide to eat only essential amino acids (that does not need to be digested and does not bring calories to my body), does it can provide me the same effects of a complete fasting? Obviously it avoids mTOR to provide his advantages, but what about the other two genes and the generic fasting advantages? Thank you. 1 Reply @xpatdoctor7322 @xpatdoctor7322 10 months ago Dear Dr Sinclair, this is one of the best channel about science and health. I am a cardiologist foccused in longevity and anti aging and you so thanks for all you trials and experience! 1 Reply 1 reply @rovingwind @rovingwind 5 months ago In my experience, going to 1, plant based meal a day has really improved my life. I do have a snack or two through the day before my main meal at dinner and still had fantastic results. Reply @leylaherr2395 @leylaherr2395 1 year ago Love your information. I have been eating 2 meals a day for 6 months, no snacks, no sugar, minimal startchy carbs. Love it. I work hard to keep my children at an absolute minimal sugar intake and junk and processed food. Can you speak more about what would be good for our children in regards to fasting or just in general what kind of food timing and regiment would be healthier for them? Would love an episode on childrens nutrition. 128 Reply 14 replies @agnesjuhasz7715 @agnesjuhasz7715 9 months ago (edited) Thank you for this information, this is so far off of what I was taught-eat 3-4 hours apart, 4-5 times a day. But it is also interesting, that my boyfriend and parents eat once a day, and all 3 have major heart and blood pressure issues. I eat 4x a day, and I am very healthy. The only difference is that they do not exercise at all, and I do weight training 4-5x a week, and have been for the last 25 years. I am 48 now 2 Reply @JaniceMarieSingleton @JaniceMarieSingleton 1 year ago This was so great. Thank you so much, I have learned quite a lot of helpful information! Both the Host and the Doctor are highly intelligent and have a sense of humor. I will return next week. Joy, Peace!!! 1 Reply @amyrorris569 @amyrorris569 11 months ago Thank you for this interview. The communication style is such that is very informative and I want to listen to all of David Sinclair’s information and interviews. 1 Reply @pennyrapp7372 @pennyrapp7372 9 months ago Thanks David. U are so easy to understand with all the good and beautiful science for and behind anti aging and a disease free life! 1 Reply @beardumaw24 @beardumaw24 1 year ago (edited) I do still eat a lot of organic vegetables and I eat one or two meals a day in a 3 to 4-hour eating period, so I generally get 22 to 24 hours of intermittent fasting each day. I do agree with him on decreasing processed meet sugars and simple carbohydrates Reply @Edina03 @Edina03 1 year ago Great tips! I actually love intermittent fasting, before starting I remember I had a few days when I ate very low in sugar, then I started eating only once or twice a day, usually between 3pm-8pm. There are very few days when I actually feel hunger. Also, focusing on anything is so much easier. 130 Reply 10 replies @7296180 @7296180 7 months ago Hi David, just want to let you know I have followed your videos for the past few years. When I looked back during my prime years (~ 30 yrs old), my work schedule was irregular, therefore, I only ate a maximum twice per day, sometimes even once per day. On top of that, I was an avid racket sports enthusiast. Played sports every other day, (quite intensive), and never stopped. Now, I am 50 yrs old, and still continue to play badminton (extremely intensive - advanced/pro level) every other day consistently, and only eat a maximum twice per day, most of the time eat once per day, with light snacks. All my friends and new people I met, still thinks I look around 30 yrs old. It seems like my aging halted considerably ever since I started eating less meals, and got into intensive sport when I was 30 yrs old. When I see some of my friends that are the same age as I am now, they all starting to have grey hair, and wrinkle skin, early stage conditions (weight gain, diabetes, high blood, cholesterol, etc.). Ironically, I weighed around 130 lbs when I was 30 yrs old, but now my weight has been averaging 120 lbs for the last 20 years, with an average BMI of 20.5. I notice it's a bit weird when my surroundings are aging much faster than I am. Therefore, when I saw your videos, I noticed there is a similar pattern that I have been on the right track for the last few decades. 1 Reply 1 reply @jessicagreg6791 @jessicagreg6791 1 year ago Love watching you guys! I've been a vegetarian since '75, I'm 51yo, glad to see the science behind the morality 3 Reply 1 reply @christinelutzko7536 @christinelutzko7536 1 year ago Great episode, super informative. Can you consume bone broth while fasting (between meals)? Reply @One-Ring-To-Rule-Them-All @One-Ring-To-Rule-Them-All 7 months ago I used to be a person that could not leave the house without having a big breakfast. I managed to train my body to go hours after waking up without food and I even run and exercise. I drink water with salt and lime and tea. I am able to reach around noon without food now (I am getting up between 6 and 6:30). One of the most stunning effects is the mental clarity! I just recommend intermittent fasting to everyone... 1 Reply @littleo353 @littleo353 1 year ago My #1 rule for health is "NEVER eat after sundown." Per Dr. Satchin Panda that causes massive inflammation that doesn't get resolved until the next day. He also said that given a choice between eating bad /unhealthy food during the day or nutritious food in the evening, it is better to eat during the day because "eating late turns even nutritious food into junk." I told this to a stranger on a golf course a year ago. A month later he saw me at the golf course and told me that he had stopped eating after sundown (he overhead me talking about this with others). he said he was 73 and a LONG time Type 2 diabetic andoften taking insulin. He said he decided to change "just one thing". he confessed that he was, as before, still cheating on the diabetes diet even drinking some beer and wine on occasion. He then said that his AM glucose that morning was 78 and he "hadn't seen such a low number in a very long time." He saw a downturn of his am glucose reading within the first week. And that's all he had changed. Another man that I know of, was morbidly obese (nearly 300 lbs) and out of desperation he decided to never eat after 6PM. he didn't know of the above but was frustrated that he had no self-control. He also decided to drink more water and he started to crave it. He lost almost one-third of his body weight in 12 months with just these two changes. And he confessed that he was still eating his favorite snack: donuts. True story from an old man who turned his health around with time-restricted eating, intermittent fasting, a few multi-day fasts and "NEver eating after sundown." 47 Reply 1 reply @eddieleong6490 @eddieleong6490 1 year ago The co-host LaPlante is truly outstanding. He controls the flow of the conversation and is also very knowledgeable. This makes the videos outstanding. 78 Reply 2 replies @Smiley_101 @Smiley_101 8 months ago (edited) Dr Sinclair , I been using some of the products you suggest on donotage for 6 months on and off but I do see a big difference on my health . In the past I would have bad seasonal allegory and it’s hard to combat it but every since I’m on them I see that it going away and it’s not as bad as before anymore and I’m more active and I def feels younger inside. I like to thanks you for doing this and I believed with matter of time this might be something good n beneficial . 1 Reply @magentamagenta1274 @magentamagenta1274 9 months ago Very interesting episode. I changed my eating habits and lifestyle four years ago due to my health problems. I’d never been keen on eating breakfast, fast food, processed food or much meat and I’d always exercised but still gained weight due to auto immune disease, high leptin, high cholesterol, stress and over eating mostly healthy foods. I became a vegetarian, then vegan alongside fasting but the weight loss was slow and minimal because I didn’t reduce my calories sufficiently during my eating window. The past year I introduced omad once or twice a week the other days I eat two meals but I count my calories and I also increased cardio walking and hiit exercises. In a year I’ve lost 13 kg, lowered my cholesterol reduced my joint pain and have more energy. I am intending to return to my 20’s weight. My advice is embrace change we can always change our lifestyle I’m 63 years old, introduce small changes until you have adjusted Don’t see setbacks as failure just pick up from where you left off and get back on track Eat foods you enjoy with nutritional benefits If you crave sugar eat dark chocolate If you get hungry brush your teeth it curbs the hunger craving, drink water, distractions work if you occupy your brain to forget hunger Hunger is just a brain signal not a danger warning.. Eating at certain times becomes a habit that signals hunger. So changing your eating times breaks the habit and signals. We can all change if we want to a sustainable lifestyle is the goal not a quick fix diet. Reply 2 replies @julieannawalker3381 @julieannawalker3381 1 year ago I love the geek humor you guys have!!! The learning is awesome too; however, your ability to keep moving forward after a super great joke amazes me. I get derailed, but, appreciate your ability to move through it keeping on point shows respect for our time. 1 Reply @LovreetShergill85 @LovreetShergill85 1 month ago First of all, thanks for taking time to do this podcast. I would really appreciate if you could answer my question below. I like to skip breakfast and have a late lunch and dinner. I also fast 2 days a week and go to gym 3 times a week, rest of the week i try to be active by doing other physical activities. But i have come across this info that due to our circadian rhythm our metabolism lowers towards the end of the day. So its not a good idea to eat a large dinner as we are going into our sleep cycle as body starts down-regulating some hormones and up-regulating other. If you could shed some light on this, that will be great. Thank you. Reply @heatherashare9121 @heatherashare9121 1 year ago Please do another series. Some topic ideas: Idea#1: Deep dive into intermittent fasting: Not so much about the benefits because you know those but about how to do it especially for people who struggle with appetite regulation. Identifying some different fasting options as well as, what to do in the face of hunger? How do you know when to push through the hunger and when to eat something and what should that food be? Sleep and fasting: what do when you can't fall asleep because of hunger. Idea #2: Calorie restriction diets - what they are, how do them, who currently does them etc. Idea #3: More about looking younger and non-invasive ways of looking and feeling younger. Thank you so much for your amazing work! 1 Reply @gro16 @gro16 1 year ago Thank you for finally making things clear as the title is, for the average non scientist humans. What list can we take to the vitamin store and what list to the grocery store and the times to take them. Which vitamins have to be taken with other vitamins and/or fatty food etc. Thank you so much to both of you. Thank you David for bringing Mathew LaPlante onboard to ask the questions that normal people ask and doesn't back down until he has an answer that the normal person can take to the store with them or just use at home. Thanks guys. 65 Reply 5 replies @attilameszaros7976 @attilameszaros7976 1 year ago Great episode indeed!! I have a question related to the time restricted fasting: It absolutely makes sense why skipping just lunch isn`t the best idea because one cannot reach 16 hours of fasting like that. Although I was wondering whether is there any difference between not eating breakfast and have lunch and dinner or have breakfast and lunch but skip dinner? Thanks in advance for the answer! 2 Reply 2 replies @AJ.943 @AJ.943 1 year ago Subscribed! Great information David…..and great channel; thank you for creating it! Keep spreading your knowledge; and we’ll keep listening! ✌🏻🤍 Reply @edwinbrace4681 @edwinbrace4681 1 year ago I am watching this while eating Chick - fil - A, I am enjoying eating fast food/junk food once a month. Depriving yourself of foods you enjoy is a bad idea, something that this episode highlights, and I agree. 2 Reply @mfajardox @mfajardox 11 months ago My story in a nutshell: People told me to eat more (3 times), you’re malnourished, but I’m not hungry! So I did, weight and cholesterol went through the roof. 2 years ago I went back to my old ways reinforced by the ideas presented here. Steak and veggies OMAD, every day. All my blood tests checked out and I feel great again. Best part, I lost 45 pounds in those two years. I’m winning at soccer games easily too 😁. 8 Reply @GlynTaylor @GlynTaylor 6 months ago Been fasting in the mornings, which is when I exercise, 30min run + 60min weights. Then for lunch I eat high fat and protein, very low/no carbohydrates. 5 days doing that and wow, I have crazy amounts of energy all the time. First 2 or 3 days I was extremely hungry, and struggled with low energy during weight training. That rapidly went away. I used to get tired in the afternoon, which I now realise was because I ate high carb lunch. The increase in focus is WILD Reply @aengusgiblin2284 @aengusgiblin2284 1 year ago I think we are extremely lucky to have podcasts like this. Thank you for your work 🙏 44 Reply 1 reply @eleonoragrange7825 @eleonoragrange7825 9 months ago Excellent Podcast, thank you Dr. Sinclair for all the info you shared- I wanted to ask you, what do you think about soy as a source of protein for someone with breast cancer gene in the family? Thank you so much again, greetings from Argentina! Reply @majaber1 @majaber1 1 year ago David Sinclair is such a great communicator, slightly difficult to catch all he is saying because the interviewer talks before he finishes his sentences. DC - always hugely informative, clear, and succinct. Thank you. Reply @caprizik @caprizik 1 year ago Hi David, thank you for this helpful knowledge you shared. Could you speak more about eating fruits, when is the best time for them and what is the benefit versus the sugar spike? 2 Reply 1 reply @maritzafernandez1880 @maritzafernandez1880 7 months ago Hola doctor Siclair, le escribo desde Nicaragua, soy fiel seguidora de sus podcast, pero me cuesta un poco ir traduciendo pues no hablo inglés, sería posible también grabar en español? Le saludo y le felicito por tan destacada labor. Reply @lauraangelides9104 @lauraangelides9104 1 year ago Love your book and greatly appreciate your podcast! Reply @avigars97 @avigars97 1 year ago It's so valuable to be learning this on the side of doing a molecular biology degree. All this knowledge and insight is greatly beneficial to my focus. Thank you! 47 Reply 1 reply @e.saaaaa694 @e.saaaaa694 1 year ago Dr. Sinclar, I've been discovering you for several years and I follow some of your advice (fasting at 16:20, Vit. D3, K2, Metformin, shower with cold water). I see that for you all the measures taken for longevity have worked and your biological clock has turned back. Even physically, you look younger, you don't have gray hair (we are the same age, but I have a lot of gray hair), but now I see that you don't even have forehead wrinkles anymore. I want to ask you a question because I'm a bit confused. Your forehead is smooth, not even facial wrinkles are visible. Is this the effect of the program you follow in terms of longevity or did you do botox? Maybe it seems funny as a question, but if it's the effect I talked about, wow. If it's botox, I'm disappointed. 9 Reply 3 replies @Chris-kc2xk @Chris-kc2xk 1 year ago Good sound sensible advice and information thanks Dr Sinclair. My wife and I intuitively decided to cut back to 2 meals per day about 2 weeks ago and we have both lost weight but not been hungry. Cut out all bread, pastries, cakes and processed food. Increased salads, vegetables, fish and a little chicken. Cut out all red meat. We both have more energy and look better. No puffiness or fluid retention. And a bonus is my wife's arthritis in her knee has lost the swelling and she is walking easier. 16 Reply 2 replies @blackmarketarmy @blackmarketarmy 1 year ago "This podcast is about what the science says, not what's socially acceptable" - Sinclair I love it, wish everything was like that 2 Reply 1 reply @angushenderson5229 @angushenderson5229 1 year ago Hi David, Thanks so much for the great series. I'm workign towards only eating once a day, but often eat fruit as a low cal, high-fibre lunch. I know some fruit like grapes are high fructose, but would shed more light on eating different fruits and their effect on fasting and ageing, please? 1 Reply @SeanMcCool @SeanMcCool 1 year ago First time listening to and watching Dr. Sinclair, and I really like his down to earth, not dogmatic, approach to all this stuff. Love how he is willing to admit that he still loves meat and is not all that motivated. Very refreshing. 104 Reply 5 replies @carloscarion1748 @carloscarion1748 11 months ago I have been fasting and eating a minimal amount of calories for well over 35 to 40 years, and I can tell you that I have benefited greatly from it. When I was much younger, I was a burgeoning singer, and as such after a gig I would go out with the band and everybody would eat have a big hearty breakfast and then go home and go to sleep, The next day or evening that is I would have another job singing and I found that my throat had a lot of problems my voice was raw and I just didn’t know what to make of it and one day I got a piece of advice from Meredith Monk and she said do not eat after you sing, which I summarily followed through on add to my great surprise and happiness my voice did very very well so having achieved that result I endeavor to continue this habit well I had no idea that what I was also doing was increasing things like autophagy and sell replacement and SATs and such but I knew that I was feeling wonderful every morning after I worked, I resolved to always make this my motive living and I haven’t looked back since. I hesitate to tell you my age, because I am still very vital and want to continue doing my craft, suffice it to say my appearance in my age have nothing to do with each other Reply @fiaflodtrollslanda2484 @fiaflodtrollslanda2484 10 months ago Great video! I'm curious about if time restricted eating plus being in a caloric deficit causes the cortisol levels to stay high for too long every day? Can't this cause issues like depression, thyroid issues, among other things, and rapid weight gain(rebound issues if you loose weight while calorie restricting, and then suddenly start eating more)? I'm also curious about the whole "sugar is a big killer" thing. Doesn't all the cells in the body run on glucose, the brain cells, and even the cells that make up the immune system? And, if your immune system is kept strong, aren't you less likely to get sick and ever even develop cancer? So, isn't sugar good for the brain, the thyroid, the immune system, and the body in general? In this video sugar is said to be bad for longevity... This is very confusing and I'm really interested in more of a clarification! This topic is just so interesting so I'm looking forward to watching the rest of the videos! 2 Reply 1 reply @woolgum @woolgum 3 months ago I can’t put my finger on it exactly but I get this new age/sect feeling about all this. 😂 But; I lost 10kilos in 6 weeks by fasting, skipping sugar and wheat, eating 75% of my daily calories needed, walking and working out every day. And I think I’ll always keep fasting because it makes me feel good. Reply @tubadurantdoda @tubadurantdoda 7 months ago Everything you said about longevity is so true. I've been following Dr. Joel Fuhrman for years now and he talks about exactly the same things you talk about. Sugar and animal products shorten human life span, whereas plant-based diet increases longevity and keeps the glucose levels stable. Reply @tomjackson8955 @tomjackson8955 1 year ago Coffee in the morning. Chewing tobacco all day. Drink clean water with lemon. Huge salad at 10 pm. Eat fish or steak with salad. I dropped 60bs in 5 weeks, and it's not the first time I did it. I also use ON protein in the past. I love this new knowledge the Dr. has. Starvation, pain and suffering = clarity, peacefulness and knowing who you are and where your going! 2 Reply 1 reply @cindydeas192 @cindydeas192 1 year ago (edited) Thank you for your research and your time in bringing us this valuable information! At 65, I've done a lot of things wrong over the years, even though I knew better! But, I'm excited to know that it's never too late to reestablish better lifestyle and dietary habits that may help make a difference, in my lifespan, going forward! 19 Reply 1 reply @ivyfeenix @ivyfeenix 3 months ago 18:39 I really appreciated this statement because it's clear Dr. Sinclair isn't trying to persuade anyone to do anything...he's just providing the information and we are advised to make our own decisions. Great episode. Reply @MrQuestful @MrQuestful 9 months ago Fascinating talk, I wanted to share one farmer I know in the Bay Area who specializes in dry farmed tomatoes. He literally doesn’t water his tomatoes, he grows them in Davenport CA where it’s quite foggy and it results in a more stressed plant (as mentioned around 57:30 is a thing to revere). If you’re in the Bay Area, try out Two Dog Farms, they really are phenomenal. 2 Reply @ja-dd3kv @ja-dd3kv 1 month ago How much do you think genetics plays a part in extending longevity? I come from a long line of family that lives to 90 😊to 100. My dad always looked younger than his age. I look younger for my age but I have exercised all my life. I naturally have fasted most of my life without knowing fasting benefits. I barely drink alcohol maybe 2x a year. Your studies are so interesting. Thank you for sharing. Reply @oolala53 @oolala53 4 months ago I would’ve been interested to know in those fasting tests if they compared it against an iso caloric diet, because I have read in recent times that they find that caloric restriction has a lot of the same effects that they ascribe to fasting. Reply @Intune369 @Intune369 9 months ago I'm enjoying Dr. Sinclair's book. I work out and train, so it's a bit hard for me not to feel more hunger during the day. I guess I could have a big lunch, but does it mean I need to eat more protein and carbs? Any suggestions will be appreciated. 🙏 Reply @liviathemalazanpotatonoob5014 @liviathemalazanpotatonoob5014 1 year ago I listened to this a second time and took notes, so I can understand the mechanisms better, and so I can create for myself a more visual representation of it all. Thank you for this podcast! 82 Reply 4 replies @isabellegalipeau3830 @isabellegalipeau3830 7 months ago Thank you very much David for the information, I learned a lot! Reply @joycehandersonfriends3225 @joycehandersonfriends3225 8 months ago I'm 80 and obese. This video may have just saved my life! How can I thank you enough? God bless you! 1 Reply @mariaeugeniajimenez3254 @mariaeugeniajimenez3254 1 year ago Love, love, love this episode! So much information! Reply @JohnBurgundy @JohnBurgundy 7 months ago (edited) After the gyms opened back up after Covid I wanted to change my lifestyle, so I decided to start fasting. I wake up every morning around 5 am and hit the gym on a empty stomach. I eat between 11 and 7 everyday besides Sunday. When I started I was 235 now I am 205, the same weight I was when joined the army years ago. I have never felt better and it’s not something to do every other week it’s a lifestyle! 💪🏽 6 Reply @phsal5182 @phsal5182 9 months ago The amount and quality of information presented herein is amazing. Thank you! Reply @jalilmloukhiyeh4835 @jalilmloukhiyeh4835 1 year ago Love this episode. It is a great follow-up to the first one. Thank you, Dr. Sinclair!!! Your willingness to share the work that you have done over the last couple of decades is helping mankind in ways that we will all benefit from. Thank you!! 12 Reply @DiverBand @DiverBand 8 months ago Dr. Sinclair is absolutely brilliant and awesome. I love everything he has to say. My only issue is the following. if you are a health and exercise fanatic such as myself for the past 41 years I can honestly tell you this. If you are training hard in the gym. And what I mean by training hard is training at least 5 to 6 days a week with both weights and cardiovascular exercise….. intermittent fasting is next to impossible to do. Because intense exercise is going to drain your body and create a calorie deficit. Eating one meal a day is next to impossible….trust me I’ve tried it. You would have to really modify and restrict your weight training and cardiovascular exercise in order to stick to intermittent fasting. But this man is brilliant and I do a number of things from his phenomenal book life span. Reply @sherievaughn6475 @sherievaughn6475 7 months ago I’m 58 and started cutting out sugar when I was around 30. I recently saw several doctors for a cancer scare (not cancer) and everyone from the nurses to the doctors were shocked that at my age I had no health problems and wasn’t on any medications. I felt like a pet getting patted on my head for being good. Reply 1 reply @kevinkiffe @kevinkiffe 1 year ago Thank you, guys!! Keep up the great work that you are doing!!! 1 Reply @goRVacrossAmericaRVLifestyle @goRVacrossAmericaRVLifestyle 1 year ago David, I've watched a couple of your videos over the past couple of days, interesting stuff. I also ordered your book. Question - you talk about metformin, would you consider berberine an acceptable substitute? Its available OTC. Does it fall short of metformin in any important ways? Is it better than metformin in any manner? Reply @janeca10 @janeca10 1 year ago I feel so happy that we are getting true science through this great episode! Taking all the valuable notes! Thanks Dr. Sinclair! 🙏 😍 11 Reply 1 reply @777Iwish @777Iwish 10 months ago Thankyou Dr. Sinclair for being real and stating your own struggles and own mistakes and faulty habits. Reply @thinkofwhy @thinkofwhy 11 months ago I started fasting 22 hrs per day about a year ago, feasting (on vegan food) before I left for work. I just started doing that one day, without any hunger pangs. Although, I always had a baggie with 5 or 6 dates, just in case. Only had to tap into those dates a few times, at the tail end of a few 13-14 hr shifts (trucker). The fact that I didn't need to have a lunch, or even take a break, blew my mind. Still does. For the first 5 to 6 months I lost a lot of fat, about 10 k. At the 5 to 6 hr mark of the daily fast the keytones would kick in and my energy and mood would ramp up, maxing out at the end of my shift (11-12 hrs). I felt amazing, and that easily motivated me to continue. Now, I don't feel that keytone high anymore and I experience low energy for the first 6 hrs after the feast, which occurred initially but much milder. I think that's because I started to eat a vegan ice cream a while ago, only on Saturday though. Now I'm gonna stop that and see if my energy level returns to the original level. Either way, fasting is the key that unlocks a healthier life. Unfortunately, the mainstream food industry is not our friend. Nor is the government and healthcare. 2 Reply 1 reply @lawrencehudson8552 @lawrencehudson8552 1 year ago Thank you for your work and book. Grateful found you through Huberman's pod cast. Please don't project that fasting will be difficult. My first fast (22 days) was completely effortless. If anything day 3 may be a little challenging but once past that I never thought about or wanted food. I had plenty of fat to burn so my body had plenty to "eat"/burn all the time and I never felt more relaxed or slept better. Just remember your words have a strong placebo effect on your audience. As someone who struggled with weight and food addiction. for most of my life, fasting broke the cycle and made getting rid of the weight so easy! 6 Reply 2 replies @susannas495 @susannas495 3 weeks ago I am a new subscriber and listened with interest. My maternal aunt will be 101 years old this October and is still living her best life. Not on any medication and mobile and lucid. She is definitely not overweight now but, had been definitely plump most of her life as living in Hungary in the countryside they didn't want to look thin as that meant you were poor! Her diet would have been salamis, sausages, chicken killed in her garden by herself, fresh vegetables bought from the market. Lots of homemade cakes and cookies, ice cream in the hot summer. Occasionally Hungarian wines. Homemade lemonades. Did not smoke and walked a lot. She had Covid aged 99 and was ill for a week like she had mild flu. I talk to her regularly and she told me that her side of the family regularly lived to over 105! 😮 However, they definitely did not snack. They would have a small protein type breakfast like eggs with salami, a vegetable stew for lunch and evening meal would be cooked meats or chicken with lots of vegetables and potatoes. Followed by a dessert 🏜 no snacking at night. Fasting would be considered for the very poor and they would never consider it. How is it that they live so long and so healthy? Also, can you please reply and advise on intermittent fasting , as so far, I have heard that you can only drink lemon tea and black coffee and absolutely no food! I am 69 years old and most people think I am 40 years old. I do have a healthy diet but apart from walking I do little exercise. I work full-time still as a Legal Administrator and love my work. Why is it that some experts advise one thing and others another for fasting? 1 Reply @amonratpeavy9717 @amonratpeavy9717 1 year ago Thank you so much .I have tried to follow your protocols and happy to report that I am no longer have high blood pressure that I had to take medicine for over 25 years. I lost 17# in 1 year. Reply @tealaree @tealaree 1 year ago (edited) I had been working graveyard shifts for 5 years so I ate differently then went back to a day schedule that was sedentary due to an injury. To say the least my body gained so much weight due to sleep eating and not being able to exercise like I used to. Thank you for the info. It's been hard trying to get back to a beneficial eating pattern! 52 Reply 11 replies @MrBrianDuga @MrBrianDuga 11 months ago Great episode. Thank you. No concerns about the high oxalate ingredients in Athletic Greens like spinach powder? 1 Reply @RichPortQueen @RichPortQueen 1 year ago The routine and supplement David Sinclair uses is definitely working! I've been flowing him for years and he looks about 10 years younger than he was when I saw him the very first time. Reply @dotexe4981 @dotexe4981 11 months ago I've been the same weight my whole teen/adult life, which is around 120 pounds/55KG (I'm 5'7/173 m). People always say I am underweight, but I never get sick and I still look super young. I'm 34 years old and I still have to show my ID when I buy a beer sometimes. It does have its downsides, people not taking me seriously, women my age often do not notice me etc. but I wonder if my weight is actually something that has kept me young. 3 Reply @choochd @choochd 1 year ago Most people would describe me as lean/thin but I struggle to eat less often without going into a scarcity mentality. I find the more often I eat the calmer and more grounded I feel with fewer energy dips and without becoming depleted and ravenous as I would with only 1 meal a day. Reply @AnnTsungMD @AnnTsungMD 9 months ago Amazing and fantastic interview as always. Reply @kittana911 @kittana911 1 year ago Sooo happy you finally launched your podcast/YouTube channel. Read your book “Lifespan” and it changed my life. This medium is ideal for getting millennials/GenZ on board. Hats off! 26 Reply 2 replies @HealthForAll009 @HealthForAll009 1 year ago Thanks for this video.. as a Doctor I seriously support your point of view. 🙂 1 Reply @SilverFan21k @SilverFan21k 5 days ago Please more longevity podcasts in the near future! :) Reply @christopherneuss789 @christopherneuss789 1 year ago Hi Dr. Sinclair, what are your thoughts on coffee, tea, and caffeine on slowing and reversing aging? Thanks for the great work. 1 Reply @HitenPatel @HitenPatel 1 year ago Really interesting, thanks Dr. Sinclair. How would couple lean muscle building with fasting in the way you advocate? I eat very little red meat, but lots of chicken, fish and veg. 2 Reply @PeppyTraveller @PeppyTraveller 1 year ago (edited) I believe you are talking about the “Jain” community in India . It’s not “Genes”, it’s “Jains”. You are doing a wonderful work Dr. Sinclair . I had met one of your sponsors from India and got a sneak peek about some future plans . Excited and look forward to it !Best of luck and Thankyou for sharing such golden nuggets 🙏 Reply @aneeshaanand4472 @aneeshaanand4472 1 year ago (edited) Excellent content, many thanks for sharing your expertise and knowledge with the world! I personally think this conversation style episodes between Matt and yourself work very well, both in terms of spot-on probing further, whether to get you to elucidate or elaborate, and/or in terms of the dynamic and both your energies. 6 Reply 1 reply @adamloepker8057 @adamloepker8057 8 months ago Thank you for the motivation to avoid that vegan ice-cream place I was over indulging in, the scientific understanding really does a lot for motivation. Reply @mesketchingcars7908 @mesketchingcars7908 7 months ago Great video👍👍👍👍.I found by myself when I saw modern meds ruins me.I started to exercise in the morning.I found which foods works for my gut health,and what to avoid including coffee,sugar,carbonated drinks,alchohol.For my mental and physical health it is important to sleep well even in parts cause and not to be hungry then I'm dangerous and irritable.I'm 46 years old,but since I changed my diet,added some muscles I can score 3 points from half of the court.I'm more energetic by nature at night.I have more strength and I look younger thanks to healthylifestyle.With 186cm of height 80kg weight which is ideal for me😎 Reply @martinrohac1213 @martinrohac1213 8 months ago Amazing podcast, thanks for sharing you wisdom. I have question regarding red meat and high protein meats in generals. Dr. Sinclair said at 43:15 "...avoid super high protein, because you dont want to activate mTOR all the time". I am curious to understand this more, lets say I go Keto, I cut the sugars are which are bad. Then I start to skip breakfast and do some 16-8 IM. Within that 8 hour span, one meal would contain high protein meat few times a week. Could that mTOR activation just couple times a week be that harmful? Or is it really meant mostly as dont overdo it with meat and dont go carnivore? Reply @magnetcrusher1193 @magnetcrusher1193 1 year ago (edited) I went from eating all day to doing two 48 hour fasts and then eased into OMAD and found my body agreeing to letting me do OMAD as a compromise, I was actually going to do 48s for a while. I was desperate to get myself out of the all day eating style. I'm the type of person who has difficulty with "easing into it" and I find it easier to just jump in and over do it at first then pull back. Every once in a while I have to do the 48s again to remind my body of the fact that I can make it worse for it. I started doing this because it makes me feel better, I don't concern myself with the health, longevity or autophagy or anything else. When I'm eating all day like normal I develop a lot of difficulty with pain, inflammation and getting excessively sore after a short hike or workout but with fasting my body starts to function right, I can hike up mountains and repair and do it again the next day. I can hike up 2500 feet of vertical gain on a mountain while fasting, but I have to hike slower. As far as meat and vegan diet, we can see that long term vegan diets cause many problems, tooth decay, mental disorders, wasting away. I think that cycling meats is the best method or in other words if you consider all low glucose/fructose plant food as non-food then you are essentially fasting for 3-4 days then eating real food (meat) and if you are trying to not lose weight you add in the plant based food in between but if you are more strong minded and want to lose weight you just fast in between steaks. Just space out the steaks. You can try every 4 days or every 7 days, whatever works best. Vegan diet will eventually accelerate aging from extreme malnutrition. 7 Reply 2 replies @andreavalencia2339 @andreavalencia2339 1 year ago (edited) I back you up 100% I started doing intermittent fasting because an interview you did, whaat you shared made some much sense that I started right away, I skip breakfast and lunch and I have my first meal around 6 pm, now I can tell you that I have never felt better in my entire life, I used to suffer from irritable bowel syndrome and gastritis, and I’m 100% cured with not medication whatsoever, just fasting and exercise, it is amazing to have the science behind it, thanks David for sharing your research ❤️ 1 Reply 1 reply @user-gr2oo8bf6v @user-gr2oo8bf6v 1 year ago Following Dr Sinclairs work for a few years now and I really enjoy that he shares more about it on his youtube channel and obviously on Hubermans podcast. Thank you 🙏🏼 28 Reply 1 reply @roserye5511 @roserye5511 1 year ago have been listening on Apple podcast, but glad to see you in person here. So, just wondering how much protein you believe we should consume. I frequently read "fitness coaches" saying one should consume 1g per lb of body weight per day if you're lifting, which I think is challenging on a mediterranean diet. Reply @delphinekirkland1757 @delphinekirkland1757 10 months ago Really enjoying the science. I've been fasting since 1978. I'm 62; folks would swear I'm in my 40's. I feel great, seldom tire and never,ever get sick. When we came in and said, "I'm hungry" Momma would say, "Well jump up and catch a Kungry " .😅🤣 I grew up on my family hundred acre farm in South Carolina. We played in the sunshine all day and ate wild plums, berries, sour grass and pecans. Meals were veggies from our garden, rice and meat from our farm. Evening snacks were boiled or roasted peanuts or baked sweet potatoes. Desert was not every meal, peach cobbler in season, cake or pie on Sunday, from scratch. We ran to the other side of the property to see grandma so many times a day, without a 2nd thought. 8 Reply 6 replies @Amy-nn6qe @Amy-nn6qe 1 year ago Thanks David! Great talk! But If I am hungry and cold all the time, then what is the point of living a long life? I guess there is a balance between a good life and a long life. Reply @RiaanEloff @RiaanEloff 3 months ago Hey there Dr Sinclair. So thankful for these vids. Learning soooo much. Really appreciated 🎉 A puzzling thing that I am not clear on: At around 2:30 you mention athletic greens, and mention that you take it every day. In fact, every morning. Later you say that you eat only once a day, skipping breakfast and lunch. I have this idea that it is fasting, with the purpose of autophagy or ketoses (ketosis?). Yet, when you take the greens in the morning, you are breaking the fast. How does this work? I want to try and move towards a 12/12 cycle, slowing going into a 16/8 cycle, but these would mean I’d have to give up my morning coffee and rusk. Am presently happy to do this, for the purpose of fasting, but am now confused that you are breaking the fast, and yet saying you are fasting. What am I missing? Reply @peteraegger @peteraegger 1 year ago l have tried to study this subject in depth . So I am not a Harvard professor but for my research and what I practise is 5 days I skip breakfast lunch,weekends I just go with the flow eat lunch etc. I am 5’9” and was 205lbs . I am now 180lbs with a final target of target of 170lbs. So my research agrees with almost everything the only thing differences is the benefits of some so called superfoods number 1 liver, number 2 high oil omega 3 fish like Sardines, mackerel, salmon etc. Number 3 eggs . these 3 foods you seem to not agree that they are actually as healthy as many people say they are? Would love to hear your thoughts on this specific foods . thank you Reply @daeinkang9136 @daeinkang9136 1 year ago I’ve done 7 day fasts with just liquids- water, tea, Chinese herbs cooked down- and I do exercise like swimming and biking- the first 3 days are challenging but after my body gets used to it and my hunger comes and goes quickly without being as severe plus my thoughts get very clear and I feel like I have more energy. 9 Reply @ElenaMilitaru @ElenaMilitaru 1 year ago (edited) I wish there was someone who could tell me how I can eat less than I eat right now without getting my stomach growling and making noises. All my life I've been stressed out to eat a lot in order to keep my stomach happy a few more hours before starting to ache. Actually when I was a teenager I used to skip breakfast and I was having stomach pain because of hunger until first meal, but I wasn't having a healthy life because I was skinny and felt dizzy and weak the whole day. Then I induced myself to eat every morning and I started a better life since day but I still struggle because I don't enjoy eating and most of the times I feel like I'm forced to eat. I just wish my body would feel as strong and satisfied with less food. Also, does one with a fast metabolism tipically live less than one with a slow one? Reply @kevindonaghy3225 @kevindonaghy3225 1 year ago $10.00 Thank you Dr. Sinclair. Appreciate your efforts. 3 Reply @antonjoubert6980 @antonjoubert6980 9 months ago From my experience, peoples genetic differences make it very hard to make a one size fits all diet, but general things like fasting, eating high quality, unprocessed foods, exercise etc. Makes a BIG difference. Reply @karinak09 @karinak09 11 months ago (edited) Hello! I’ve learned over the years that IF fasting windows may need to be different for women (e.g. 14 hours rather than 16). What are your thoughts on this? Also, the “ideal” waist to height ratio seems to be lower than 0.5 for women. I may be wrong, but that’s what I’ve heard from other sources. Reply 1 reply @corinacoleman4193 @corinacoleman4193 1 year ago I do OMAD most days. At least once a month I extend my fasts 48-72 hours. My weight is normal with low side normal body fat. I started fasting last year, lost 20 pounds with just the fasting. What I eat has not changed including enjoying evening wine. I LOVE VINO!! What I have noticed is that sometimes I indulge in wine (finish a whole bottle by myself), and do not wake up with wine hangovers anymore. What has fasting done to my liver? 1 Reply @panagenesis2695 @panagenesis2695 1 year ago What he's saying about Xeno-Hormesis is 100% true! My father always told me that the grapes from dryer climates always produced better wine. And, when we would plant the family garden, my father would tell me not to water the plants too frequently or they would taste worse. And he's right! 47 Reply 7 replies @IcedCupcakes @IcedCupcakes 5 months ago This is amazing. Fasting month is coming soon and this adds to my excitement for ramadhan. Reply @Mark-tp2mz @Mark-tp2mz 5 months ago Thanks Dave, have just watched your video,am 54 and have been Vegan for 3 years due to ethical reasons, but now experiencing massive benefits to health(10kg loss of weight) cholesterol and heart issues gone . a coffee in the morning , a frozen fruit and vegetable smoothie, salad and vegan stay or Mexican dish in evening . Trying to dispense with packet of crisps and cider in evening.. never would have believed it, I used to think vegans were some strange cult. How wrong I was to find myself becoming one. If people want a strong motivator to move to a plant based diet. Please watch Dominion or Earthlings, The Game Changers, What the health. Plants are where it is at. Thanks mark Reply @jeremyfoxon6536 @jeremyfoxon6536 11 months ago Great episode gents lots of good sharing ideas. For me the aim is both a longer life but with good physical n mental health in support. You don’t emphasise that side although it's implied - 'feeling good ' is anyhow so subjective. Now I left my 60's I need to work on especially my physical side every day. There's a whole new world of senior health out there. But I look forward to your next episode. More power to you both. Reply @devonk298 @devonk298 1 year ago (edited) Oh nice - so glad you have your own channel - big fan! Your cohost is a great addition , great chemistry between the two of you. 1 Reply @keithkerns8770 @keithkerns8770 1 year ago Your program is awesome! I learn so much. Please continue the series. Suggestion: can you do a segment on serrapeptase? It’s supposed to remove plaque from arteries, and dissolve dead cells, scar tissue, blood clots. There’s a debate if it survives stomach digestion. I read a 1994 Japanese study summary that indicated it did make it into the intestines for absorption. With all your knowledge and expertise, would love to hear you delve into its efficacy. Thank you very much! 1 Reply @armieflores6064 @armieflores6064 1 year ago Thank you Dr. D. Sinclair and Mr. M. LaPlante ,a very interesting podcast discussion. Blessings be upon to all humanity for an awesome information. 19 Reply @rachellesears8189 @rachellesears8189 1 year ago Excellent information. I wish our schools & nursing homes followed these guidelines. Do you Athletic greens after fasting? Can you still run/exercise in the morning if only eating 1x a day? Reply @ambarishupadhyay921 @ambarishupadhyay921 1 year ago It will be interesting to learn how to manage fasting with physical workouts ( gym, run, bike, swim etc). I assume it will be different from fasting with no strenuous fitness regime. Any thoughts, doc? Reply @SirKickassington @SirKickassington 7 months ago I’m a convert! At 49 I tried IF again after trying and failing a year earlier. It’s well worth doing some research on how to break your fast healthily and there are lots of resources out there. But the big takeaway from Dr Sinclair and one I agree with 100% is to stay consistent in your fasting for at least two weeks. If you can do that it WILL get easier. I get up before 6am, exercise, and 6 days out of 7 I don’t eat until at least 4pm, often closer to 6pm before my one meal of the day. I had a little brain fog and distraction the first two weeks but now I feel better and clearer all day long. You’re training your liver! Give it a couple weeks to respond and start giving you the glucose you were missing. Reply 2 replies @SuperJamie @SuperJamie 1 year ago Hello this is really awesome content, thank you. Question on avoiding high protein that triggers mTOR, does it mean adding protein powder to our diet could be working against us than for us? 3 Reply 1 reply @gavinuys496 @gavinuys496 1 year ago Thanks for the podcast. When you are on medication every day, should you eat something when taking your tablets ? Reply @willcollins5660 @willcollins5660 1 year ago Thank you Dr. Sinclair for finally having a youtube channel and everything you have given to this world. 10 Reply 1 reply @pshoan007 @pshoan007 1 year ago It’s be great to expand more on the kids. At what age is it safe for kids to start skipping breakfast for example, ect. Especially in the light of their body growth. 1 Reply @RogersBenjamin @RogersBenjamin 9 months ago I'm 54. I'm type 2 diabetic. I've been on a "journey" since January 2022. Today is October 28, 2022. I am on a "keto-vore" diet - and OMAD since March. I have done a lot of fasting over my lifetime - 10 day, 2 week, 3 week fasts at various times of my life. But, I haven't done much fasting in the last few 5 years or so. In June, I decided I wanted to try a 30 day, water-only fast. The longest I'd ever done prior to that time was 22 days. I did the math and realized that if I wanted to finish a 30 day water-only fast before the holidays, I needed to build up to it and had to start right away. In July, I completed a 2 week water-only fast. Then I ate for one week. In August, I completed a 3 week water-only fast. Then I ate for two weeks. In September I started my 30 day water-only fast. I completed it on October 5. I ate for 10 days - then did another 5 day water-only fast. I have been eating since October 21. I am debating another 5 day fast next week. Then I'll have two weeks of various "thanksgiving feasts" - and after the official Thanksgiving, I want to fast for 28 days before Christmas. I never experienced the "pain" of hunger in my fasting experience because I always built up slowly. 3 days, 5, days, 1 week, 10 days, 2 weeks, 3 weeks, etc. - with healthy eating in between. However, on my 30 day fast, I noticed that at day 24, I started feeling strong hunger. I actually started feeling the "pain" of hunger for the first time. I was dropping a pound a day at that point. (Yes, I took some supplementation and allowed some salt and pickle juice.) It is definitely a mental game to fast. The first 3 days are always the hardest. After 3 days, the physical hunger goes away - but then the mental push to eat seems to strengthen. At 5 days, that diminishes. But, the brain keeps pushing to eat. It's a big mental game. You'll have thoughts like, "No doctor told you that you had to do this, why not have something light to eat?" Or "How bad could a little broth be?" Or, "Why not fry up an egg, no need to deprive yourself." Yes, actual thoughts, in my head, pushing me to eat. At this point, I feel better when I'm fasted. I sleep better. My body feels better. I have more energy (though it's shorter lived and I have to learn how to pace myself). I think much more clearly. Everyone who knows me comments about how much younger I look since I've been on this journey. My blood sugars while fasting (I was off my diabetic meds) were consistently between 86 and 100. I stopped my Metformin because I was crashing into blood sugars of as low as 49. However, I've started a lower dosage now and I'll be taking it in my future fasts (at this lower dosage). In February, having been sugar-free for a month, I asked another friend who has been on a similar journey, "When can I have sugar again?" He asked when my birthday was. It's in November. He said, "On your birthday, you can have sugar - and only on your birthday." I couldn't imagine living 9 more months without sugar. Here I am, two weeks from my birthday and I DO NOT WANT ANY SUGAR - I'm actually a little afraid of having any. I have struggled beyond my sugar-addiction for 10 months. I do not want to fight those battles again. I have no plans to eat any sugar. I want to encourage everyone that you can do this. You can get healthier. You can live longer. You can manage long-term fasting, OMAD, Intermittent Fasting, caloric restriction and time-restricted eating (there's some really interesting research on ETRF - early time-restricted feeding). You can do this! :) 1 Reply @kevb740 @kevb740 1 year ago Thanks David, love your work. One thing that was overlooked, don't have the Athletic Greens AG1 until after your fasting period ends he forgot to say :) Reply 1 reply @fustyler @fustyler 10 months ago Love your work David. On the topic of red meat, have you looked at wagyu if that is any different to other red meat due to the monounsaturated fat in wagyu? Reply @jackjack-xw1ci @jackjack-xw1ci 1 year ago Dr.Sinclair, thank you for your services. Reply @sarahpellett8737 @sarahpellett8737 1 year ago Thank you so much for sharing all of this information on what a proper, healthy, life saving diet should consist of. I eat up (no pun intended haha) all the info. I can on diet and nutrition, however there is so much contradiction between the different popular diets out there and what’s trending this week that it’s super confusing and frustrating and easy to just give up. I’m grateful for your knowledge and expertise. I’m intrigued with all you’ve shared and excited for what the future holds for each one of us. 15 Reply @slodkoejka1266 @slodkoejka1266 1 year ago Hi, David. Nothing was mentioned of eating fruits (but I heard from David that fructose was bad). So is eating fruits bad as well? Or does the fiber keep the fructose within and our bodies pass it all? Also, if eating fruits is Ok, is eating fruits mid-16-hour cycle considered to be snacking? (snacking is bad, from what I understood). 1 Reply @darwell9563 @darwell9563 1 year ago David, thanks for sharing your knowledge. Reply @freeyoga @freeyoga 1 year ago Your presence and presentation were most helpful and prompts me to take a turn. From a Keto based diet towards modification plant based keto. I am in my later life also! 70 and want to dance as long as possible the crawling dragging lifestyle does not really appeal. 😝🤗 Reply @dnorstrand3070 @dnorstrand3070 10 months ago Thomas DeLauer suggests a touch of salt in your liquids to help with the feeling of hunger. Definitely helped me with fasting (I’ve gone up to 3 days). Reply @kire8220 @kire8220 1 year ago Wish I had studied biology instead of going into the military 20 years ago. I guess I should be thankful that we live in an age where this information can be applied to better health in a practical way. Reply @jaimesilk7648 @jaimesilk7648 1 year ago Excellent podcast. I have a background in neuroscience and have always been passionate about nutrition and exercise. This is the best accessible information I’ve come across in 15 years! 22 Reply 3 replies @winstonmontag586 @winstonmontag586 11 months ago Very useful conversation, thank you for sharing. Reply @JD-hy2pg @JD-hy2pg 10 months ago Excellent! Very informative. Thank you for sharing. Reply @LJ-mc3rv @LJ-mc3rv 1 year ago One thing I did when I started was the night before, I thought of what I wanted to eat. And ate what I desired. And so on and on. And then as I saw the weight starting to melt off I then began to eat healthier. For me, that's fruit and salad. Reply @0121bassline @0121bassline 4 months ago I do the 18/6 fast starting from 6pm so I'm asleep during most of my fast which makes it way easier. I do this twice a week for a month , twice a year as I do bodybuilding and struggle to keep my size. Would that be enough to gain all benefits though? I also read that its more beneficial to do alternative day fasting so you fast one day then not the next then fast again etc . Unsure why it could be better than just fasting for 2 continuous days though ? Reply @josephedmonds8252 @josephedmonds8252 1 year ago I just attempted to compress my daily intake into a single meal in the early evening. The quantity of food that ended up on my plate was astounding. A full dinner plate piled higher than Everest. Have I simply counted the daily caloric intake wrong? Do I need food that is more calorie dense? Or does the method of one meal a day in the evening reduce the number of calories you actually need per day? 1 Reply 1 reply @pabloolfe1834 @pabloolfe1834 1 year ago It seems that in order to improve our health and longevity we need to put our body at the mercy of adversity regularly. Thanks for your outstanding insights!!!! 61 Reply 2 replies @kiranmodi8183 @kiranmodi8183 1 year ago Thanks for the pod. How do you weigh up the risk of increases in lactic acid with taking metformin as a supplement? Reply @decomposingTunes @decomposingTunes 1 year ago Love the interviewer. He asks the questions I would. Appreciate very much his healthy skepticism. Reply @explorersoftheworld1193 @explorersoftheworld1193 1 year ago thank you for very valuable and useful knowledge, I would be interested in the topic of fertility in women, how to care for it and whether it can be kept 4 Reply @richardhuebner4144 @richardhuebner4144 9 months ago I love the Mediterranean diet. I naturally choose the foods that pertain with it. Now if I can just feast on it once a day I'll live to 150 😄 Reply @MurderinkAustralia @MurderinkAustralia 1 year ago I have been practicing fasting since my teens and am now 41 and appear as if I’m in my 20’s. Reply @Aembeschiss @Aembeschiss 1 year ago I follow the 16-8 protocol for years now and I'm trying the extended version of it)(20-4)more or less like suggested by doc sinclair currently... It's is quite tough to get into it - I can definetly agree to the fact that sufficient drinking is key to magae hunger until the evening! I'm currently evaluating whether the effects (caloric deficit, focus, and longterm health befits) are worth and doable the effort. Love this kind of scientic and life hacking content! 😁 6 Reply 1 reply @jimimckenna7431 @jimimckenna7431 1 year ago Dr Alan Goldhamer, Dr Sten Ekberg, and Dr David Sinclair are great sources for information on fasting. Reply @anniepais700 @anniepais700 1 year ago Okay- doing all of that. 73 years old. Still curious about what my body wants and needs. It's been a long haul- trying to go against the culture that largely 'feeds' us one false and dangerous trend after another. I am still curious- please talk with us- we've been around for decades trying to be healthy! Trying to stay off meds and away from an old age centered in doctors offices. Reply @metalgamedog @metalgamedog 1 year ago I'm sorry David, in Italy especially in Sardinia and on an island in Japan they eat a lot of protein sources, the oldest woman in the world who was Italian, her grandmother Morano 117 years old, ate raw minced meat for almost all her life, 2 eggs raw and 1 cooked ... we have studies on the longevity of vegetarians that if we go and see they do not even reach a national average if not rarely. 5 Reply @punitbhardwaj5405 @punitbhardwaj5405 11 months ago THANKS FOR PROVIDING SO MUCH IMPORTANT INFORMATION. Reply @gustavoivancruz8397 @gustavoivancruz8397 1 year ago I'll be skipping dinner! We'll see how it goes! Thank you for so much valuable content! Reply @romanrubtsov3783 @romanrubtsov3783 1 year ago Thank you for this episode and a lot of valuable information provided. I've been living like described for the last 5 months and I feel much better know. The only problem that remains is that sometimes I just need more energy that comes from bigger amount of food and I haven't figured out until now how to solve. It is not that I need junkfood at times, just bigger amounts of good foods. I am studying almost all the time and this food (along with the fluids) is a great source of energy, for with food I can manage to study all the day with short breaks, with the right approach I am evidently lesser productive. 8 Reply @kronk358 @kronk358 1 year ago What a noble thing to do with your life. Thank you Reply @margaretfaulkner8127 @margaretfaulkner8127 1 year ago I have been only eating one meal a day since my early forty’s. I am now 66. Just felt better cutting out breakfast then a lot of the time just wasn’t hungry for lunch so it evolved. I am a lot healthier for the fasting. Reply @jerryspiteri68 @jerryspiteri68 1 year ago I've been doing OMAD for 2yrs now..and lost 35klos in 8momths . I'm 53 and eat 5pm sometimes break it up 3pm 6pm etc. 1c a month I'll not eat for 94 hrs . I feel great FANTASTIC ON THIS!! I exercise and have full on abs and are teaching people fir free on how to eat . 5pm 23/1.... 2nd day...3pm...22hrs 3rd day back to 6pm...25hr Then 5pm for 1. week. 1c a month on Celtic salt minerals I won't eat for 94hrs And have more energy after the 2nd day. Lots of trial and error. But I look younger skin is beautiful BMI index is now... 53yrs old.... Score = 96% Visceral fat....3% Subcontanious fat=7%. Muscle mass is great more definition veins. Nitric oxide CITRULLINE MALATE L-CARNITINE Apple cider vinegar Mineral water no more grellin pains gone in 9 months Resveratol with avocado And a little olive oil. Boron... And other special supplements. IT WORKS you need to pass through the barriers. NO SUGAR NO FRUCTOSE NO CARB'S UNDER 10%good carbs. Your body will make it anyway through protien if it needs it. 1 Reply 1 reply @thetraveler79 @thetraveler79 5 months ago From 20 to 35, i wasn't controlling my emotions very well and i ate a lot of desserts... I started to understand myself better and learn a lot on fasting, insulin and health. Will i have a fatty liver or already have one? Reply @Articulate99 @Articulate99 1 year ago Always informative, thank you. 2 Reply @DrGayleDelaneyDreams @DrGayleDelaneyDreams 1 year ago This is such a useful and pleasant format! I am enjoying getting to see how Matthew La Plant thinks, organizes and interacts with David. I hope. you decide to continue this series for another 30 or more episodes. If you would like some questions and feedback on your first two intros presenting your donors, just ask. A few modifications might work better. I had a radio show and know how difficult it is to read ads. If I knew I would live another 50 good years, I would start my neurology, biology, etc. courses. This is so very thrilling! 6 Reply 1 reply @nedybox9207 @nedybox9207 1 year ago Hi. May I know if there has been studies on this method's effects on WOMEN -- specifically to our estrogen cycle, hormones, and the possibility of getting amenorrhea? I lost my period for a time once and regained it by cutting back on exercise and stuffing myself with lots and lots of food. I got my period back after a few months and I've been eating normal and exercising again (nothing too stressful). I'm terrified my period might stop again. I've been doing OMAD and have gone pescatarian for more than a month now and I've lost about 3-4kg easy -- which is pretty concerning too, I guess? Thank you so much for the valuable lessons on longevity. I'm a naturally petite Asian (4'10" and 49kg), and turning 45yo this year. Menopause is just around the corner but would also like to delay that (aging!) by following the good doctor's fasting recommendation. Is it reasonable that I fear hormonal imbalance? Reply @SalmanBadshah786 @SalmanBadshah786 5 months ago (edited) Dear David, I really appreciate you talk about Ramadhan. I feel my skin more younger during Ramadhan fasting for 30 days. It also help us fight against so many diseases. 5 Reply @annafrances6883 @annafrances6883 1 year ago Any advice for folks who struggle with gastritis? (No h pylori, not a paucity of hcl- just gastritis.) Its proven tricky for my stomach lining to fast longer than 16 hours. Reply @Magrotth @Magrotth 1 year ago Fascinating!!! Although.... I might stop with this podcast (the only one I have watch of these series), because I am reading the book and want my brain to work its way through to many of these things by itself! Then I will watch the podcasts, to clarify to myself, what and if I didn't get something in the book! xD :P Apart from that - I love everything that Dr. Sinclair does for Humanity!!! Deep prostration to him!!! 1 Reply @rst7379 @rst7379 7 months ago Certainly there's lot of value in this content, but it is not easy to understand by a layperson. My BMI is 24. I tried fasting just skipping one meal (dinner or breakfast) but I ended up having too much stomach acid and serious throwing up after 2-3 days of fasting. Any suggestion how I could overcome this? Reply @eriklindblad4135 @eriklindblad4135 1 year ago Hi David! Great episode! I've been doing 16/8 fasting since 2009 but is doing 18/6 since I started following you. I am also a glaucoma suspect and your research has given me so much hope and less worrying. I have two questions: 1. Meat is just slightly higher in BCAA per 100 gram of protein than, fish, chicken, low-fat cottage cheese and whey. Even soy, lentils and quinoa are almost as high in BCAA. Would eating a more plant-based diet still be beneficial if BCAA is still high? I need to get my protein from somewhere. I am an amateur weightlifter but also care about longevity. 2. You mentioned limit fructose. What about whole fruits? I eat a lot of both fruit and green leafy veggies. Thanks! 53 Reply 17 replies @Cindy-by3ho @Cindy-by3ho 1 year ago Thank you for your information. I hate when a second person is always interrupting. You should film yourself speaking about this subject without anyone else present. It is much harder to retain the information with so many interruptions. 1 Reply @janetgies8698 @janetgies8698 1 year ago My Mom is 92 and overweight and eats poorly and of coarse is pre-diabetic. There is a difference between being old and crotchety and old and at the (individually) best possible all-around heath for advanced age. I’ve been enjoying 17-18 fasting as I have my first meal w/33 grams of organic brown rice at 1 or 2pm and my final meal at 7:30 with the second half of the rice bowl. I’m determined to plummet my A1C below 6. Learning to fast regularly will help me not be anxious about fasting for a Colonoscopy. I used to eat 2 breakfasts! 🫢 Reply @phoenixgirl11 @phoenixgirl11 1 year ago Love the podcast. Very exciting about the Mediterranean diet being the best for longevity. I grew up eating that way[ being European) now I’m doing a 14-16 hour intermitting fasting and hoping to add 30% to my life span. I’m 66 years young 😀 10 Reply 3 replies @lisafranchi9650 @lisafranchi9650 8 months ago This is super interesting. Two questions: 1) when you mention cut fructose, does that include fruits (i hope not..I love fruits;)) 2) when you say avoid proteins (or meat proteins), I wonder if collagen counts as proteins..I take 5gr it in the morning.. Thanks!! Reply @zarimohammadinia2120 @zarimohammadinia2120 7 months ago Dear Dr. Sinclair, thanks a lot your words make me closer to my aims. Grateful 🙏🍁🤍 Reply @plantbasedathleterealtor6145 @plantbasedathleterealtor6145 1 year ago (edited) I am grateful all your podcasts 💫🙏🏻 Reply @baba-sm1fm @baba-sm1fm 1 year ago (edited) I am originally from Italy, Sicily to be specific. I grew up eating a diet made mostly of vegetables and pasta, chicken or fish about once a week and rarely eating red meat ( probably once a month).We include 1-2 ounces of local wine with lunch and dinner, we NEVER drink alcohol between meals (we are culturally against the idea of abusing alcohol). We do not have breakfast, just a coffee. My dad is 96, his mom was 97 when she passed, but only because she fell and broke her hip. My aunt ( his sister), was 97 when she passed away. None of them had any health conditions. I am a 57 old woman with no health conditions, continuing the same diet but unfortunately not in Italy, therefore being that the quality of food here in the USA is not optimal, I will probably have a different outcome. Reply @Freed0mOfS0ul @Freed0mOfS0ul 1 year ago (edited) David this knowledge and wisdom from your research that you’re giving away for free is an absolute blessing I hope people realize that because many people that truly understand life realize like you that the way things were given and blessed to you you bless others with can’t wait to hear this podcast 9 Reply @Emptyness210 @Emptyness210 11 months ago Thank you very much sir, I appreciate it tremendously. Reply @JB-ub4mo @JB-ub4mo 1 year ago I eat a Mediterranean diet with daily 20/4 intermittent fasting. I do a 72 hour fast at the beginning of every month. I feel great. Reply 1 reply @jlateda04 @jlateda04 8 months ago We used to be cold and hungry more often. But our lifespans were much shorter. Help me understand this 1 Reply @dominiquemall9014 @dominiquemall9014 1 year ago As an physician myself I totally agree with him I am vegetarian and thankful for that Good for me the animals and the planet Reply @mdrnprimitve-wesupportsmal6507 @mdrnprimitve-wesupportsmal6507 1 year ago David love the work you are doing on this subject, your going all in, i think you have raised the awareness.. just a little giggle though.. Im actually going to try athletic greens - the one stop shoo for all your needs... well almost as your two offer vitamin add ons says.. made me smile .. Reply @AmericanEagleInvest @AmericanEagleInvest 1 year ago Awesome content David! Thank you so much for sharing your up to date and powerful information to us laymen. Is there any way to get a transcript of the podcasts? 4 Reply 1 reply @robbiem3878 @robbiem3878 8 months ago The science of this makes sense to me. My question is will this work the same for menopausal women as they are discovering our body systems stop functioning they way they used to. Examples: brain fog, memory recall problems, belly fat you can't loose, hot flashes and many more which are in response to hormone reduction or imbalance. Is fasting going to "fix" the hormonal problems? I often find I can't think or focus well in the morning if I don't have some protein or fat. MTC oil in my coffee seems to help but then am I breaking the fast? There are also people saying you need to eat protein in the first 30 minutes of waking to get your metabolism started. If you get up at 6 or 7 you would have to stop eating around 1 or 2. I don't see that being very doable. I hope someone will do these studies on menopausal women specifically. Maybe they are out there but I just haven't seen them. Reply @gatakaas8586 @gatakaas8586 11 months ago I watch all the videos that I can with dr. David Sinclair. He is a legend. I love to see how younger he looks compared to some older videos. I have only one question: did dr. Sinclair have some cosmetic procedures done? Botox? Face lifting? Or his appearance is 100% due to his lifestyle and supplements? I don’t care if he had cosmetic procedures done but I would like to have an honest answer. 1 Reply @carmenerickson9050 @carmenerickson9050 1 year ago Million thanks to the HOST AND COHOST! 👏🏼👏🏼👏🏼 Reply @philesq9595 @philesq9595 1 year ago Behold. A man that is focused on finding ways to extend happy, healthy existence rather than novel ways to make ourselves miserable through gluttony and violence. Eating less is also beneficial for the environment bc we aren't constantly scavenging for more resources to satiate an artificial appetite. Thank you. May God bless all those who encourage beauty in all things. Reply @Imperial_Dynamics @Imperial_Dynamics 1 year ago (edited) as a Greek I'm happy to hear that Mediterranean diet is good. Also we have an island here in Greece, it's called Icaria, where many people grow older than 100 years. Reply 1 reply @firetornado4787 @firetornado4787 1 year ago Bless you guys for putting this incredible information out into the world. Thank you so much 3 Reply @lifereviews74 @lifereviews74 8 months ago Im still in the middle of this podcast and the virtue that i got from this talk is SELF CONTROL. A huge amount of self-control. Reply @andreaalexandraskordai6410 @andreaalexandraskordai6410 8 months ago Büszke vagyok rád Dávid, sok sikert! Reply @faith5401 @faith5401 1 year ago Im do glad i hv found this awesome channel. As i know red meat or meat is bad n toxic for health. Pure Plant based diet is the Best food n it has cured many diseases indeed. Tq Sir for yr Sound information. God bless u n this can also save many poor innocent animals lives. I love animals much 🐾🐾🐾🐾🐾♥️♥️♥️♥️ 2 Reply @shaydz2622 @shaydz2622 4 months ago Dave, as a fellow Aussie, i am asking you to please push these companies you mention at the start to have full options from here, we also want better insight into our health 😔 Reply @AnaGutierrez-jh3uq @AnaGutierrez-jh3uq 10 months ago Doctor Sinclair, with much respect could someone from your team edit in Spanish this video, it is very important to be able to understand everything. Thanks a lot Reply @DoctorJack16 @DoctorJack16 1 year ago This series is awesome! I have grown really interested in botanical health and understanding nutrition further. This just confirms what I’ve been researching. Thank you! 17 Reply 3 replies @heatheringram2976 @heatheringram2976 7 months ago Can you build muscle only eating protein at dinner time? I didn’t see any muscle growth for years until I started eating about 70 grams a day. Curious if I’ll still build muscle eating one meal? How much protein should be in that meal? Menopause started this year at 52, so I’m trying to shed belly fat and try fasting. Thanks 1 Reply @JoseHernandez-ew5xc @JoseHernandez-ew5xc 7 months ago wow very interesting video, i never saw these this before, even though I've been practicing fasting for quite sometimes. definitely a new sub. Reply @mariusalparaque8417 @mariusalparaque8417 1 year ago I sent a tweet to President Biden & VP Kamala Harris to listen to Dr. Sinclair’s podcast. Thanks Dr. Sinclair for the research & scientific work you are doing in your lab . Cheers & Blessings ! Reply @Talpham @Talpham 1 year ago Very nice podcast, I might do my master thesis on optimizing the epigentic clock. Hope to meet you one day in my academic carreer! Reply @ajitesh764 @ajitesh764 1 year ago What drinks to have to keep going throughout the day, I mean to avoid that feeling of nausea, fatigued. What drinks do you recommend to maintain the electrolytes balance to get us going through the fasting period? Reply @PetitFlorals @PetitFlorals 1 year ago That was a fantastic episode. I really enjoy your content. Thank you for putting this information out into the universe so that more people can learn. 14 Reply @adonaiblackwood7172 @adonaiblackwood7172 9 months ago Wow! Wonderful information in this episode. Thank you, Doc! 🙏 I love the Mediterranean diet.. I basically don’t eat mammals.. I limit gluten & sugar (I like agave, honey & stevia sometimes), and I try to eat a variety of veggies & include fish & some poultry. I eat between 3p-7p, go to bed around 11p and wake up around 7a, I drink lots of purified electrolyte water, take turmeric, do a lil bit of yoga and qi gong, I release stress and anger and keep an open mind and stay humble and grateful. 🖖🤍😉 4 Reply @feiwong8782 @feiwong8782 9 months ago Great advice thank you! Reply @michaelvli @michaelvli 1 year ago (edited) Thanks for the podcast, Dr. Sinclair. One question: Do you take the Athletic Greens in the morning? I was confused because I also heard you say that you only eat a minimal amount of yogurt with your supplements in the morning. Can you please clarify in the context of only eating dinner. Since listening to your podcast, I've been only eating dinner and am trying to fast for 23 hours a day and plan to extend this diet to eating every other day once I adapt. Thanks again! Reply 2 replies @kaboom669 @kaboom669 7 months ago (edited) David Sinclair eats one meal a day, yes but he snacks multiple times a day as well. From several recent interviews, I ve gathered that he starts the day with a small cup of yoghurt/ coconut yoghurt, to go with his fat soluble supplements. Up untill his one meal, diner, between 7 and 9, he snacks on nuts and 80 percent plus chocolate. He probably has a 12 hour eating window which actually correlates with dr Longo 's proposed and scientifically backed ideal eating window of 12 hours. 1 Reply @EN-yc4fw @EN-yc4fw 8 months ago That's unbelievable. Just watched DS's TED talk. That was 9 years ago and he looks MUCH younger now! 1 Reply @andreipopa5540 @andreipopa5540 1 year ago Very informative! Would be interesting how to balance fasting with how much to eat and what is REALLY essential. Also some alternatives to the different supplements and foods which are available to people who really don't have money. 3 Reply @JMSsssssss @JMSsssssss 1 year ago (edited) Honey and maple syrup? Vegetables 🤮 I have to disguise them. Is an overripe avocado a stressed plant or just overripe? You inspired me to fast intermittently today. I'm a nurse and by the time I got my supper break I was absolutely starving, that was difficult. I skipped all the snacks. Cutting out carbs will take a while or possible never happen. I am really interested in monitoring my glucose. Reply @ll.steam88 @ll.steam88 9 months ago (edited) When i intermittent fast I become extremely underweight to a point people think I'm throwing up my meals. And that's even if I eat two meals not one. So i have been making myself eat three meals a day just to maintain a healthy weight. So it feels almost impossible for me to intermittent fast. Any advice for someone like me? Reply @oolala53 @oolala53 4 months ago I did two meals a day for several three-week rounds about a year and change ago. I wasn’t really trying to lose weight and I did lose weight but 40% of it was muscle. It makes me very reluctant to try it again. 1 Reply @nancyevans5176 @nancyevans5176 5 months ago Nurse here David. You mentioned Jim Nelsons’ study in that depending on your genetics you might not want to intermittent fast as much, but how would you monitor to rate if this is helping your longevity… My Sirt1’s and foxo3’s are all good, and I have two centenarians - grandfather and great grandfather.. 65 and not any past med. hx or on any meds so far. And innnately I have always tended toward one meal a day. And predominantly plant fish bean diet with nuts daily. But is there anyway I can tell/ monitor to know if I’m one of those possible 50 percent that would benefit. Please elaborate. I do my blood sugars only to monitor for spikes and fasting levels. Thank you. Reply @markmarcinik5818 @markmarcinik5818 1 year ago I believed in the vegetarian, low fat , low sugar diet even when my health began to fail. I stepped it up instead of listening to my body. The best diet is one that your body thrives on. Diets can’t be dogmatic. No one can tell you what works for you. Reply @burakdemir3546 @burakdemir3546 1 year ago As a biochemist, I am amazed of this channel. I've been following Dr. Sinclair for quite a while now and can for sure say he is top notch. IF mixed witha medit. diet is the way to go. Greetings from Germany! 7 Reply 1 reply @jabon112 @jabon112 10 months ago Thank you for this! What supplements do you suggest? I am a healthy 60 year old. Reply @tomipontynen5642 @tomipontynen5642 1 year ago I have been 2 yrs on intermittent fasting, skipping dinner. But I also believe due to animal tests that methionine restriction is good for longevity. Methionine is absolutely necessary for cancer cells, so why to feed them more. My diet is plant based version of Mediterranian. Sometimes I take a 2 dl glass of red vine on lunch. Never in the evening as my sleeping would get disturbed Reply @juliusfister7140 @juliusfister7140 1 year ago A superb presentation! Reply @5ziga5 @5ziga5 1 year ago Dr. Sinclair, greetings from Slovenia. I've been on the 16/8 intermittent fasting meal plan since January and when I did the lipid panel blood test in April I was a bit shocked. My HDL level was too low (before it was within normal range) and my LDL level was too high (before it was within normal range as well). I'm doing the blood test again. What should I do if the result is the same? Thank you in advance! Cheers, Ziga Reply 1 reply @PeterTheis @PeterTheis 11 months ago HOW MANY DAYS in a row should one do the 18:6 fasting (eating only in a 6 hour window)? Every day forever? Monday through Friday, then relax it on weekends? Or…? Reply @Somkatoozi @Somkatoozi 1 year ago What a great talk. Love how informative it is, and at the same time how easy it is to listen to and understand. Thanks guys 4 Reply 2 replies @albwilso9 @albwilso9 1 year ago I have studied a lot of Physiology, and learned how important good diet is, BUT all the Corporare propaganda fooled me for a long time, but videos like these and others helped to inform me. I wish we had all this good information 30 years ago!!!! Reply @londonspade5896 @londonspade5896 8 months ago I have a question, how do people handle 'longevity' diets with social events? If you're with your friends at a restaurant, it would be too tempting for me not to tuck into some delicious food (not fast food I just mean a steak or something with rice for example). 1 Reply @lindah8632 @lindah8632 1 year ago Okinawan diet: White rice wouldn’t spike you if you paired it with the correct fats and protein (shokuiku principles) or cooked it alone with the shokuiku principles in mind (add plenty of olive oil or another healthy fat or a combination of 2 or 3 healthy fats). Add the best organic combination of spices and you have a very tasty and healthy rice dish with a lesser to minimum spike. Reply @sparklingmists @sparklingmists 1 year ago I wish HSA could be used to incorporate some supplements and tests. I agree with my PCP that some of this is definitely over testing and part of it is not interpreted in the ways these labs do. I don't mind paying more for that. I don't expect a PCP to order tests like these. I wish there was more on prolonged fasting and methods of breaking prolonged fasts. Reply @lucasbulsara8822 @lucasbulsara8822 7 months ago When training - sports science shows branched-chain amino acids like leucine are really useful for hypertrophy and that protein synthesis is maximised only in a state of positive nitrogen balance. So what's the best way to balance the need for ingestion of good quality protein after training against boosting the autophagic system and reprocessing of old proteins? Could protein recycling work? i.e Eat protein around training days /sessions only? Reply @motionman0 @motionman0 1 year ago For all the cynics out there. You guys need to define fasting or intermittent fasting a bit more. Couple of spoonfuls of yogurt first thing in the morning or Athletic Greens in the morning is technically breaking the fast. Love everything you guys are doing! 8 Reply @Skyandgrace @Skyandgrace 10 months ago Great info as always however I’d pass on metformin as it’s known to cause liver issues Reply @leeferguson1077 @leeferguson1077 1 year ago Amazing series! I would like to know though please how are you fasting all day if you are having athletic greens in the morning? Surely this would break a fast? Or is this a plug for the sponsor? Any info on this would be greatly appreciated. 1 Reply @JadesFitnessBucketList @JadesFitnessBucketList 1 year ago This episode depicts clearly and concisely the plethora of benefits to fasting. I myself have been fasting for years and have so much more energy and gousto for life, as well as getting better sleep and performing better in my sports... however i have heard a lot of negatives on women fasting...is there any truth to this? it sometimes frustrates me hearing supposed 'health professionals' profess that woman in particular should not fast but I would like to know if there was any truth to this and if so to please show me some scientific literature if anybody could knew?? Reply @loui9102 @loui9102 1 year ago I really like your work, but there is not such thing as longevity we come to this frequency and leave when the Universe wants us, nothing can change that, now your teaching definitely will give a very quality life while we are here🙏 Reply @henrysnotebook543 @henrysnotebook543 1 year ago Hi Dr. Sinclair! Great content! I do have a quick question for you. I vape and I was wondering if vaping is going to break my fast? Looking forward to your response. Thanks in advance! Reply @Razklili @Razklili 1 year ago Thank you so much to share your knowledge and give us a generous access to the science. I also love when you share your personal protocol with us. 5 Reply @connieacevedo4709 @connieacevedo4709 10 months ago I think you should promote more of how we are aging children and the outcomes in the future on their health. Many portions of society are not nutritional educated. Reply @cristiansabadac7797 @cristiansabadac7797 7 months ago I'd like to know if the use of essential aminoacids, obtained from plants, could be useful in a plant based diet. As they do not need to be digested, could they be useful in prolonging the time in which the body do not digest? If taken in the morning, with coffee, do they break the fast? Does the body react in the same way as it would to meat, or eggs, or cheese? Or the lack of need for digestion could trick the body into not stopping the beneficial activities linked with the lack of proteins? Taking just aminoacids with a vegan diet, would be better than eating meats, eggs, cheese? Thanks! Reply @suzanneclemena4992 @suzanneclemena4992 10 months ago After having like the flu and already haven’t eaten you have already naturally fasted so I take that time to hop on the 16-8 fasting window Reply @ChazZen @ChazZen 10 months ago So is trying to gain maximal amounts of muscle inherently bad for aging? Even if you're trying to eat 1.7g/bw in kg? I know you can gain a good amount of muscle on a low protein diet, but back to my main question-gaining maximal amounts of muscle and eating for that goal is bad for aging? Reply @marcellpaumkirchner2563 @marcellpaumkirchner2563 5 months ago Measuring is very important. What should a person with average budget measure? Blood panel including what parameters...? Weight? Sport performance? Blood pressure? How often (all)? Thanks! Reply @mcelia @mcelia 1 year ago 3 minutes in podcast number 2 and have to thank you for doing this. I've been watching all kinds of videos trying to figure out the fundamentals of aging. I've taken the subscription on athletic greens, sadly it is nog possible to join levels from the Netherlands. Please always only work with sponsors that you actually support, because I trust you blindly. 3 Reply @thestreamoflife1124 @thestreamoflife1124 1 year ago I've been drinking athletic greens for 3 months now and love it Reply @sandraslutz9489 @sandraslutz9489 1 month ago Hey Dave, just wanted to thank you and the company you co-founded MetroBiotec, for getting the FDA to ban over the counter sales of NMN. Doesn't make much sense to buy your "Lifespans" book since you can't get the NMN anymore. I heard you did the same thing with Resveratol, but it still seems to be available. Reply @JC-hh5lu @JC-hh5lu 1 year ago I'm a nurse working night shift, do you have any advice for staying healthier while I destroy my natural biological rhythms? Reply @tamer3476 @tamer3476 1 year ago Great podcast, for reducing sugar does that include pasta and bread ?? Reply @ajl8615 @ajl8615 1 year ago I am interested to know what does Dr Sinclair have for his one only Vegetarian meal? As an Asian Chinese, the vegetables we eat probably not the same as westerners? Thanks for giving your answer for my question 🙏🙏 Reply @bootlegskate @bootlegskate 1 year ago Would love a little more info on fasting times for women of reproductive age. I'm 34 and have been doing 14 hour fasts sometimes can stretch to 15 but it's pretty difficult. I am breastfeeding a 2 year old although it's really for comfort not food so I'm not too worried about that, but also have a short menstruation cycle ~21-23 days and would like to try get pregnant again in the next year. I always wake up hungry and I'm waiting to eat at 9am instead of 6/7... If I make dinner any earlier I'll be eating at 430 and might get too hungry to sleep. I've seen lots of articles but not peer reviewed about how fasts have been studied more on men and give men energy bc they evolved to get energy from starvation to be motivated to hunt. For women I read we just hold onto fat to preserve pregnancy/milk production/periods etc. This is such an awesome podcast but like some others it would be so awesome to hear a little more about actual biological sex differences. 80 Reply 17 replies @OIrvin @OIrvin 1 year ago This is wonderful. Simply, what do you say about fruit? Should we eat it? What fruits do you recommend and when should we eat them? Reply @gunhildjohanne9187 @gunhildjohanne9187 1 year ago Hi Dr. Sinclair. I purchased the Athletic greens. I practice Intermittent fasting - is it okay to drink the daily dose of Athletic greens in the morning when I'm fasting? I typically skip breakfast and eat my first meal at 11.30 am. Thanks! 2 Reply 1 reply @user-sq9yb6nm5u @user-sq9yb6nm5u 1 year ago I start to believe this now as I never thought of Chinese dish before but my grandparents they all have this type of lifestyle they don't call "diet", and they are still alive at their 90s. Rice, veggies, and small amount of fish...and 2 meals a day in appropriate amounts. Reply @allisonblaustein7898 @allisonblaustein7898 8 months ago (edited) Take away for me: Try fasting that works for you. He said he will have A tiny bit of yogurt In morning and then super hydrates during day , including Athletic Greens. Only true meal is dinner. He is vegetarian. ( could ease into it by eliminating big breakfast and once comfortable eliminate lunch ) (Another method is fasting 1-7 days periodically) -Avoid sugar. -Exercise. -Avoid high protein (plants enough ) Fish good. At least make veggies largest percentage of meal. Olive oil good. -Limit alcohol -It’s ok / normal if not 100% rigid. 58:00 final take aways 1. Eat less often. Skip one meal , when comfortable move to two skipped. No snacks. No sugar. Stevia good. If do have anything sweet do it at end of meal. 2. Reduce red meat and processed meat. 3. Plant based. Organic , local & colorful. 4. Mediterranean diet effective and easy. 5. It’s never too late & don’t have to adhere perfectly 6. Adversity is healthy : feeling hungry. Excercise. Heat & cold therapies. 1 Reply 1 reply @myrna5833 @myrna5833 2 months ago Dr.Sinclair, what dose of NMN do you recommend? During fasting, can I take my supplements? I take a handful of supplements 2x a day. Reply @franzmanz9916 @franzmanz9916 1 year ago I have been fasting as a lifestyle for almost 2 years now. Primarily for autophagy. The first year, I did OMAD mostly. Felt really great and lost weight. The 2nd year, I decided to add more upper body strength and muscles to improve my physique. So I went to the gym regularly. Took longer to gain muscles so I increased protein intake by starting to eat Lunch and bit of carbs. Now I look good comparatively. So, what I learned from your podcast now is how to balance Longevity goals, versus Muscle growth (MTOR). Given my age, mid 40s, ill stop adding more muscles and focus more on Fasting and Exercise. Is this a fair compromise/approach? 43 Reply 11 replies @jenniferwinston7842 @jenniferwinston7842 9 months ago Thank you Dr Sinclair. I'm still skeptical..... these efforts can have negative effects on policies and farmers, as well as the infrastructure to feed the country. Reply @bobbyjunelive1993 @bobbyjunelive1993 1 year ago Eventually we will meet. Your efforts are stunning. Thank you. Reply @georgeandkatherinedrager3705 @georgeandkatherinedrager3705 1 year ago I bought his book lifespan why we age and don’t have to about 3 years ago after watching a few podcasts and this guy looks younger now since then I have taken nmn resveretrol metformin olive oil and fasted since then didn’t tell my doctor. My doctor told me I am like a poster boy for blood work for someone my age Reply @yoyomo777 @yoyomo777 9 months ago David said he was going to say which vegetables he preferred then he didn’t 😢 What a tease! I guess I’ll try meatless Mediterranean Ty 🙏 2 Reply @duchessofmeraniamerania4744 @duchessofmeraniamerania4744 5 months ago I like Dr. Sinclairs to explain how to get rid sugar addiction. Reply @yayangtapir4130 @yayangtapir4130 1 year ago I had been listening to all your interviews...but this podcast is the ultimate one. It made everything super clear. Thank you Dr Sinclair. 20 Reply 1 reply @gigilaroux762 @gigilaroux762 7 months ago It’s strange because I am insulin resistant and yet whenever I switch to protein and low glycemic fruit for my carbs I lose weight. If I eat brown rice even or complex carbs that are starchy I stop losing. Everyone’s body is different. Reply @dinorahavalossanchez3952 @dinorahavalossanchez3952 10 months ago Thank you for your support for world’s health. You look amazing like a 20 year old young man. Reply @coachderrick3736 @coachderrick3736 8 months ago went on a 2 week water fast. Feels great! 1 Reply @sellingcasas @sellingcasas 1 year ago When you have your athletic greens in the morning, doesn't that break your fast and prevent autophagy from kicking in? Reply @maritzafernandez1880 @maritzafernandez1880 7 months ago Tengo una enfermedad autoinmune "síndrome de Sjogren" y estoy segura de poder superar mi estado, hago ayuno de hasta16 horas , pero me gustaría me hiciera una sugerencia. Saludos Reply @KD-eq4xi @KD-eq4xi 1 year ago (edited) This was amazing!!!! Dr. Sinclair, bloody brilliant mate....Your explanation of the science behind everything was crystal. Your explanations were paced, not too fast so I was able to absorb and process all of this information. Matthew asked all of the right questions, Kudos!!! This will be on repeat, my go to video. Now I have the understanding and the answers to my particular situation based on your breakdowns. Excellent tips!!!!! New subscriber✌️ 13 Reply 2 replies @LosCabos209 @LosCabos209 1 year ago Dr.Sinclair, I'm a big fan of your work. Could you please let us know your take on eggs? Thanks in advance. 1 Reply @dnorstrand3070 @dnorstrand3070 9 months ago Interesting that he’s considering vegan when blue zones showed that within vegetarian populations there was a specific sub population that lived longer, the people that occasionally snuck some meat or fish. And a number of the blue zone populations include egg in their diet. I’ve seen a couple articles where the oldest person in the world at the time credited eating an egg or two everyday for their longevity. Reply @johncardona1107 @johncardona1107 1 year ago Dr. David , how you doing and Thank you for Sharing your knowledge, may I ask How to deal with not eating at night and not became with Ulcer ? Sometimes I get this little pain and I need to eat something right away and goes away . Please advise and Thank you . Reply @loveleenkaur4279 @loveleenkaur4279 8 months ago Would you recommend NMN for people on the pregnancy journey? Is it a safe drug to take during pregnancy? Reply @ellissmith8160 @ellissmith8160 1 year ago GREAT CONVERSATION...I WASN'T EATING A LOT.. I'M JUST TOO SKINNY..I WANT TO BE HEALTH Reply @shelleyboa3883 @shelleyboa3883 1 year ago So happy you have created a youtube channel David!! Such an amazing gift to share. I went plant based about three years ago, then I kind of fell into IF. I found it easy to go to 16/8 but now I am 20/4. Thank god, working from home now, its kept pandemic weight off. Im almost 60. I lost my meno weight, leaned out and maintain my muscle mass by doing regular Ashtanga. still doing dropbacks and handstands. brain fog gone, IBS gone. also no more jet lag from long flights. I really get an instant feedback loop on what causes inflammation in my body, and when I avoid those foods, I feel immortal most days, like I used to in my twenties. its all amazing except my sleep. that is still a crap shoot. 50 Reply 18 replies @mattz9440 @mattz9440 8 months ago Love your work, David. Question/comment: Fructose combined with fiber. Almost cancels out blood sugar spike. Have you researched it? Associating fructose with whole fruits 🍎 s is incorrect. Fiber is key. Surprised you haven’t studied it or left it out of the conversation. Reply @heidiroy-kerckhoff1527 @heidiroy-kerckhoff1527 7 months ago I am so grateful for him.. Reply @angelamason4414 @angelamason4414 1 year ago How do I get enough food/nutrition in one meal without feeling sick? I have so many questions! Reply @tarekhanna6556 @tarekhanna6556 8 months ago (edited) Vitamin b3 and vitamin b13 could be useful due to NAD+ Pathway . It could be even better than NMN . (B13 oroic acid) 1 Reply @kay9man159 @kay9man159 1 year ago I'm curious to see the research on this TMA molecule in meat and what the difference is between grass-fed beef versus processed meat Reply @yehongchen4341 @yehongchen4341 1 year ago It‘s really great to having co-host Matthew here, he helps me to understand much better, thank you! 13 Reply 1 reply @Digi4DD @Digi4DD 5 months ago I love how Matthew is playing devil's advocate and trying to dig into any issues that might render some topics irrelevant. No blind faith, just data Reply @kimfroman2023 @kimfroman2023 1 year ago Thank you so much for quality captions! 1 Reply @khadijadingsdag8841 @khadijadingsdag8841 10 months ago Hi David, can you please comment on keto diet (or link any interview if you addressed it elsewhere). I do keto low carb on 1 meal a day, but plan to ditch meat, which makes it really hard with food choices. You talked about low carb, but assume that implies mostly low processed carb, and on vegan/vegetarian part one can get all protein from relatively high carb foods such as legumes? Thanks Reply @dmitrykandov277 @dmitrykandov277 7 months ago Is it better to have that one meal before the daily workout or after? 1 Reply @brendahornung1990 @brendahornung1990 2 months ago Thanks! Getting the book today! Reply @lorabutler6402 @lorabutler6402 1 year ago Absolutely love the podcast. I hope you do a follow-up Q & A podcast. I'm curious how to pack in a day's worth of calories in one or 2 meals a day. I struggled and was losing too much weight. Also, what are your thoughts on eggs and our need for choline? And, how much fish was eaten on the pesco vegetarian diet you cited as giving 19% reduction in death? 5 Reply 2 replies @marlosvet @marlosvet 2 weeks ago Another great Episode!! Reply @simong7735 @simong7735 1 year ago Dr. D is there a chart of what/when to eat 🤔 I’m looking to limit my young daughters sugar intake as I’ve taken mine way down though I hear it calling me 😂😂 I just ignore the call and am doing 1-2meals a day and normally about 16-18hrs between meals however I’m confused about the carnivore diet and plant based. Which one will make me live longer and look after my daughter for many many happy years to come. SimonFromOz 😀 Reply @susanadirim8426 @susanadirim8426 1 year ago 2 questions. What about greater protein for older people? I am64. Also I wanted to asked about the French paradox. Not just because of red wine. How do we explain it? 1 Reply @MissesWitch @MissesWitch 11 months ago One meal a day is something I followed myself for a very long time.. If I don't do that, I am not healthy! It's been so many years I've eaten like this, Most of my life. Reply @almiller5711 @almiller5711 1 year ago Love your pod cast the world needs your research I do intermittent Never too old to start doing I am 79 recovering from a stroke could you say something about optimizing Nuro plasticity in the brain incoming episodes Reply @redpilllense7125 @redpilllense7125 1 year ago (edited) This information is so valuable, that even the immortal Dracula is taking notes! Thank you so much, Dr. Sinclair 🧛‍♂️👍 75 Reply 1 reply @anitasanches5726 @anitasanches5726 1 year ago Dr David Sinclair is the 16 hours of fast also recommended for women( adults and pre menopause)? Thank you!! Reply @a.k.bartleby4295 @a.k.bartleby4295 1 year ago is it ok to drink caffé latte, coffee-with-milk during intervalls of fasting (16/8) or does the milk interrupt the intervall? Reply @mr.ambientsounds1291 @mr.ambientsounds1291 1 year ago (edited) To think its considered "controversial" to say plant based diets with mostly whole foods is good for you and helps you live longs 1 Reply @christineoffthegrid6373 @christineoffthegrid6373 7 months ago I'm curious what this does physiologically for women. From what I've read, women have an entirely different response to fasting then men do. Men are also generally able to shed fat more easily and quickly than women. Especially during menopause and times of high stressors on the body - childbearing/nursing years etc. Women also respond to stress differently than men do, physically, so it makes sense that these suggestions may not be the best for women and actually contribute to weight gain and not to longevity by taxing the adrenals further. Thoughts? Reply @msbmsbus @msbmsbus 2 months ago It is hard for me to imagine that we will ever reverse aging if we cannot reverse baldness. Or, will it be that if we reverse aging, reversing baldness will be a part of that? Reply @RunToTheHills999 @RunToTheHills999 1 year ago This series will change so many lifes for the better. Thank you for sharing your knowledge with the public. 4 Reply @petrawilken5861 @petrawilken5861 1 month ago So, Dr Sinclair, do you mix your green powder with your yogurt? or do you mix it with water and then have the yogurt? does the green juice not "break" the fast? Reply @KonstantinUrban-bn4cr @KonstantinUrban-bn4cr 7 months ago Would eating nuts or fruits (banana, apple) during the day count as a meal? Is that ok or shouldn't I do these intermediary food intakes? Reply @vickigould7838 @vickigould7838 1 year ago fantastic info... thanks guys Reply @LemonWatermelon @LemonWatermelon 1 year ago (edited) David mentions red-meat is bad for us. We in india have a nationwide ban on red meat (beef) since may 2017. Would be interesting to observe how this law benefits our large population. Also, it would be very interesting if science could suggest how bad each type of meat is - if we could compare shrimp, fish, chicken, lamb and know how bad they are and derive a sort of recommended amout we could consume to get the protein without activating mTor. Or maybe a conclusion like 'these many grams/bodyweight activates mTor'.Thank you David I love your approach. Reply @ronaldgarrison8478 @ronaldgarrison8478 1 year ago 32:08 You certainly don't want a reactive hypoglycemic episode. I've triggered one on a few occasions. Fortunately there was food close enough to abort it.Scary, and dangerous. There are also other horrible states related to hunger, but the hypoglycemic episode is one where I know what will trigger it, predictably. Reply @jaisriram6178 @jaisriram6178 1 year ago (edited) Key takeaways: • Cut-off artificial sugars (processed carbohydrates) • Cut-off meat or atleast start reducing it from your diet. Meat lovers can switch to Mediterranean or Okinawan diet models. • Practice intermittent fasting. Start with skipping breakfast and try to avoid snaking in between. Tip 1- if its harder for you to practice I.F. then start drinking warm water, black coffee or green tea. Tip 2- if its still hard then consume a handful of nuts (as they contain proteins and healthy fats) and wait for 20 minutes. Tip 3- You can try natural sweeteners like stevia. • Consume more colored vegetables and fruits. Go for organic if possible. • Meal order- Consume proteins and vegetables first. • Start doing strength training and walking • For longevity, vegetarian and vegan diets are the best. 320 Reply 105 replies @martintokar7893 @martintokar7893 7 months ago (edited) The most important show (and book) ever. Thank u 😊 Reply @anmayo917 @anmayo917 2 weeks ago (edited) Please talk more about protein intake and practical evidence about health and age/longevity My omnivore brain is still resisting to change its mind about those tasty organic and grass fed schnitzels Edit: vegans/vegetarians are oftentimes living more health-conscious in general. You also mentioned fish is apparently fine, but most fish don't contain much omega 3s. So is it, based on the literature, possible to judge the effects of a diet containing vegetables and "good" meats like organic poultry? Reply @fignewton8690 @fignewton8690 1 year ago I have to say muscle mass needs to remain relatively high during old age. Lean muscle mass seems to be in conflict with sirtuin pathway and keeps mtor pathway turned on. There is something missing here Reply @thecryptospecialist2651 @thecryptospecialist2651 1 year ago Watched some of your videos, and also heard that red meat is good if you do not overconsume it and if it is grassfed organic, and that without it you have problem to get the right amount of Iron and b12 to give you the right amount of energy what is your take on that? Reply @verikogurchiani7003 @verikogurchiani7003 1 year ago The cohost makes it even more interesting! Thank you! 1 Reply @nickivanov6846 @nickivanov6846 1 year ago (edited) Unfortunately any of these protocols may not work for your body if your are under chronic stress (Mental/Emotional/Physical). Thank you Guys for this podcast)) 6 Reply 1 reply @MD-fd3cq @MD-fd3cq 1 year ago David, what oil is best to cook with? Extra virgin olive, Cold pressed rapeseed Avocado? Any others? (I’m sure David won’t see this, so anybody else? 😀) Reply @oliviamiller8187 @oliviamiller8187 1 year ago Life expectancy has jumped, mainly because infant survival rates are much higher than they once were. Poor hygiene and nutrition, less advanced medicine and more communicable diseases meant that newborns in Ancient Greece and Rome had a much lower chance of surviving their first few years. But by combatting age-linked illnesses, we can extend our life and live until a hundred and fifty. I too have spent a lot of time confused with the push back to ending death and extending human life. As more people see it as a true option, I hope they’ll move past the fear of death and see it’s all really quite possible! It’s through Dr. Sinclair's podcasts I learned about Vitruvin Anti-Aging Supplements and ever since I am taking this NMN supplement, it radically changed my life. Reply @nuray3486 @nuray3486 1 year ago Wow Dr David Sinclair is 52 years old but looks like 30 something to me!!!! (26 June 1969) I shall apply his formula in my life!!! 1 Reply @DannDann01 @DannDann01 1 year ago When we do intermittent fasting can we still take nutrients, eg athletic greens, during the fasting period? Reply @ldnpanther82 @ldnpanther82 1 year ago Does this mean we shouldn't eat fruit or drink smoothies because of glucose/sugar intake? I usually have fruit for breakfast, should I change that? Reply @James-mk8jp @James-mk8jp 1 year ago I thought David would've gone into more depth than he has in his previous podcast episodes with other hosts, but it seems to be the safe information. Would've been nice for more detail on, for example, cooked vs raw vegetables, what he specifically eats to get enough calories in such a small window, etc. I know people have been asking him these things for a while and he continues to dodge for whatever reason. 27 Reply 11 replies @bobbytrav67 @bobbytrav67 11 months ago This might seem crazy but David looks younger than his TEDxSydney talk posted here 9 years ago! Take look and compare. I have been following some of these recommendations, taking NR for about a year now, Mediterranean diet, low amounts of red meat, daily exercise ...etc for a while but I think I am looking about 5 years younger so far stated from people I know who have no idea what my birth age was. Being in mid life I am looking forward to setting the biological clock back more to a time where I was more at my best physically and mentally LOL (meditation helps a lot, positive thinking can certainly reverse what negative thinking does to our bodies, doing things we enjoy with others). Great to know this information as to take positive actions for a healthy long life. Thanks to David and for getting out there and promoting this research to help people. Reply @SilverFan21k @SilverFan21k 1 month ago More of these in the future ❤ 1 Reply @veganlifestyleloveanimals1744 @veganlifestyleloveanimals1744 9 months ago The 7th day Adventist in the USA. I am from Sardinia and we are wholefood plant-based here. My grandparents are both well over 100 2 Reply @guillermofernandezdecastro596 @guillermofernandezdecastro596 6 months ago Excellent, thank you very much. Reply @MrClinior @MrClinior 1 year ago Incredible, thank you! Reply @CourtneyCoulas @CourtneyCoulas 1 year ago Thank you for this information and all the time and work that you've put into it. I have long been a fan of fasting, both long fasts and time restricted eating. I have been trying to fine-tune my nutriton as well as I come across new information and research. I have a question regarding protein. I've been led to believe that the under consumption of protein is detrimental and that eating enough protien will build muscle and protect the body later in life. I've been following the P:E Diet from Dr. Ted Naiman, as well as a high protein style keto with whole foods, based on research from him and other experts. The reccomended intake of protein in these communities is roughly 0.8g -1.0g of protein per lbs of lean body mass. What would be your recomendation for protein intake based on your research? 7 Reply 8 replies @michaelm7822 @michaelm7822 3 months ago (edited) Hi Gents, can you please clarify David's protocol for intermittent fasting is basically 1 meal within 24 hour (Dinner)? I understand he takes some supplements with 2 -3 spoons of yogurt around noon and only eats normal size dinner. Is this correct? I just started 18 hours fasting diet but I do have 2 meals lunch at noon and dinner at 6 pm and might or might not have some nuts/fruits around 3 pm. Please clarify. The aim is one meal a day or its ok to have lunch and dinner as long as we fast from 6pm to 12 noon next day in order to get the liver to start producing glucose? Thank you. Reply @Pepyrss @Pepyrss 3 months ago 39:54 - don't you break your fasting then? P.S. Thanks for the amazing podcast! :)) Reply @m5Yb7Ds @m5Yb7Ds 1 year ago A quick question. Is the deer velvet growth hormone supplement a good source of the IGF-1/2 when stacked with Metformin and DHEA? Reply @mylesjeffers6148 @mylesjeffers6148 9 months ago I'm skinny already. I'm not concerned with fat loss at all. Can I still get the calories I need whilst intermittent fasting? Reply @amymoriyama6616 @amymoriyama6616 1 year ago I'm here because I went down a YouTube rabbit hole last night and came across a video with Dr. David Sinclair and when he said he was in his early 50s, I had to pick my jaw up off the floor. I said no way. He looks like he's in his 30s. It appears the proof of his research is himself and I like what I see. 1 Reply 1 reply @mihaisau7999 @mihaisau7999 1 year ago Hello, This is really a good podcast and a good learning experience. I know that you have the subjects already planned, but in case you decide to do a bonus podcast, here are some items that might be interesting: - Fat-soluble vitamins - Antioxidants - Gut microbiome - Infrared therapy - Circadian rhythm - Optimized breathing - The state of happiness Thank you. 5 Reply @richricogranada9647 @richricogranada9647 1 year ago It looks like not satisfying our hunger is a good thing. The pain of being hungry is healing, and the longest it remains that way, the better. Reply @persona5305 @persona5305 1 year ago (edited) oh well, didn't know that my eating habit is good for me😅 I always thought that maybe there's something wrong with me.. i don't feel hungry in the morning, not even until lunch so I just eat some fruits or do my avocado shake until evening.. dinner is when I eat the most but that's it. the problem is that I have adhd and i do more workout for the sake of my brain therefore I become hungry after that... so now, i noticed that if I don't eat enough for the day, I become more tired and my adhd symptoms become worst. is there a remedy for that or should I sacrifice the longer fasting instead? I'm not really aiming for longevity but more on quality life which mean balance healthy brain so I could function normally on daily basis. 1 Reply @robynhope219 @robynhope219 5 months ago (edited) Problem is: I am underweight due to low DHEA. How to intermittently fast when you're skinny? Reply @lorinichols1847 @lorinichols1847 1 year ago The studies you cite regarding meat consumption -- do they specify or differentiate between commercially raised vs. pasture raised/finished meats? I would think that might be quite significant.... 1 Reply @jeanp6029 @jeanp6029 1 year ago You mentioned drinking AG in the morning. Is there no insulin response from doing that? I'm wondering because I am doing 20:4 but maybe I should drink it during the 4 hour eating window???? Your thoughts please? 2 Reply @saifalarabi4491 @saifalarabi4491 1 year ago My great grandfather lived 110 years with no diseases and he was active till the last day of his life. He followed an Arab lifestyle, eating mainly dates, olive oil, with milk, and lamb meat from time to time, their bread was from unrefined Barely, and they were usually mixing dates with olive oil. But the most important he eats less always, as a lifestyle. 52 Reply 15 replies @leighpierce2964 @leighpierce2964 11 months ago Does fasting have negative effects on the hair cycle? I have read that the stress of fasting can result in shedding.... 1 Reply @tensecondbuickgn @tensecondbuickgn 10 days ago I lost 25 pounds going to one meal a day and I've never felt better. If I'm really hungry at night, I'll have a teaspoon of peanut butter or a spoon of cottage cheese. Reply @rocoHuana @rocoHuana 1 year ago Question ✋ If i do intermittent fasting and eat clean all the time or If i just remove sugar and bread I keep on losing weight, even If i eat a lot of healthy food. Thing is that I dont want to keep on losing weight because my face is worse looking if i am too skinny. How to maintain weight and bmi in a healthy way? Reply @Raeez100 @Raeez100 3 months ago There seem to be some inconsistencies. He says that he avoids deserts to prevent spikes in blood glucose. The thing is that many deserts like ice cream(51) and chocolate (30) have a low glycemic index because of all the fat they contain. Food like potatoes (upto 80), brown rice(68), whole wheat bread (75) have a much higher Glycemic index. How can we consume a low protein, carbohydrate rich diet without spiking our blood glucose levels? Reply @imawesome1822 @imawesome1822 7 months ago My mother drank 2 cups of coffee with cream for breakfast and didn’t eat anything all day till dinner and snacked on fruit while watching tv at night since I was a kid. She died a horrible death of ovarian cancer at 70. She did smoke two packs of cigarettes a day for 55 years though. Diets don’t work ! It was the coffee cream I think that did it Reply @qdmudong @qdmudong 1 year ago David, thank you so much! I read you book last August and it changed my life style in a big way, I started watching video from other scientists about nutrition, eating, metaboli… I gave up sugar almost completed, I’ve been taking cold shower since, I eat once or twice a day now, working out about five days a week… I have one question for you, for your plant based diet, what is your main protein source, do you eat a lot of beans to get protein? Thank you! 14 Reply 1 reply @freespiritwithnature4384 @freespiritwithnature4384 11 months ago Brother went off all allergy needles once he stopped using Bounce Sheets. The mice stopped chewing through the trailer where we dropped it on the floor. I heard it’s made from slaughter house scraps. No more migraines. I bought sauerkraut,but it says nitrates are in it . Reply @ChannelJtotheD @ChannelJtotheD 1 year ago Interesting discussion on longevity. Is it only red meat that is unhealthy? What about other meats like chicken, fish, prawns, tuna, lamb, bacon, eggs, liver and dairy. Thank you Reply @reneyoo6111 @reneyoo6111 1 year ago (edited) When you drink coffee its actually pretty easy to dont eat for a day , because it stops the hunger feeling. One iced-americano a day keeps the hunger away xD Reply @anmayo917 @anmayo917 12 days ago In another podcast you spoke against cured meat for its nitrate/nitrite content. Though, the majority of people's n. intake tends to come from vegetables. Can you please elaborate? Reply @bonifaciobonifacia8679 @bonifaciobonifacia8679 7 months ago I got normal, fbs and all after I got IF, my problem now is I get skinny and want to gain weight a little bit without increasing my numbers again. Any suggestions. Thanks Reply @Isa-ye3kk @Isa-ye3kk 1 year ago Greetings grom Germany!!Now I know what's happening during and after a few days fasting. I confirm that I felt amazing great, superfit, my skin looked younger and clear. I losed weight and my taste of any food was very intensive. Great feeling! 3 Reply @edithharmer1326 @edithharmer1326 4 weeks ago Educational! Great Tutorial! Thank you for sharing your Amazing talent and knowledge! Greetings from Singapore 🌹🌹🌹 Edith, a happy and appreciative Subcriber Reply @beverleycumming1876 @beverleycumming1876 8 months ago We had three meals growing up however no snacks..if we were hungry after dinner mom said well you’ll be ready for breakfast…no candies except for a piece of chewing gum on a Saturday…we ate a ton of potatoes…no weight issues whatsoever Reply @michellesummers1010 @michellesummers1010 1 year ago You said you skip breakfast to contribute to your time restricted eating (fasting time), but then said you take your athletic greens first thing in the morning. I have recently started using athletic greens, but am concerned about all that nutrition telling my body the fast is over. So, do the athletic greens stop the fast? 1 Reply @kon1837 @kon1837 1 year ago I want to know if it is okay for skinny people to try fasting. I eat 3times a day, as much as I want, and I weight 40kg(88pounds). I want to try fasting if it's good for me, but is it a good choice for me too? Will it make me even skinnier?(I don't want to freak ppl out I already look boney) Reply @ChristineBeltran @ChristineBeltran 9 months ago Interesting on plant stress. Plant stress is when they plant matter is also best for creating essential oils. 👌 Reply @goddessoworu8944 @goddessoworu8944 1 year ago ♥︎Thank you for sharing this information; following your research for about 2 years now. Been on a vegan plant based eating since 2011 + I know that a vegan plant based eating of high nutritional foods can & will rejuvenate the body - clean chemical free lifestyle as well ☽☆☾ Just Know there are lists of plants that kill cancer cells however there is not 1 animal flesh that can do the same 👁‍🗨 7 Reply 1 reply @Botanifiles @Botanifiles 1 year ago For anyone curious the NAMPT gene stands for nicotinamide phosphoribosyltransferase Reply @garrettmoore1549 @garrettmoore1549 3 months ago (edited) Is it the actual feeling of hunger that stimulates longevity genes? If so, why would drinking lots of fluids and eating a portion of nuts to kill an appetite not defeat the purpose of fasting? Reply @TheEarthstory @TheEarthstory 1 year ago I have been doing intermittent fasting however after my 16 hours I start my first meal with fruit. Bananas...mangoes whatever is in season. I hear about no sugar but does that apply to fruit.? I also need to know if drinking herbal teas and apple cider vinegar drinks are ok during the hours of fasting or should those only be consumed during the 8 hour window. I have my dinner at 5pm. Reply @BloomByChristine @BloomByChristine 1 year ago So educational! And, so nonjudgmental. We’re all human, of course we all want cake and a steak… but…does that serve us???? Reply @JohnDoe-tu8ky @JohnDoe-tu8ky 3 months ago If your audience can’t comprehend cancer and aging they are not listening 51 minutes into the podcast 😂 Reply @MrCodyborn @MrCodyborn 1 year ago First of all, thank you for all of the great, digestible content. I hope you get some fulfillment from helping the many people who are able to improve their lives from your research and videos. Although there is a lot of overlap, it seems that there's a natural opposition between muscle building and longevity. Personally, I prioritize longevity over muscle gain and maintenance, but I also don't want to sacrifice where I don't need to. From my naïve understanding, it seems that compromise could be found by either altering days of focus (ex. 4 days calorie restriction, 3 days high protein) or my consistent moderation (everyday moderate protein intake & intermittent fasting). Is there any research that you're aware of that shows evidence one way or the other? 4 Reply 1 reply @GodisSemperfidelis @GodisSemperfidelis 1 year ago Basically the biblical diet scientifically explained. Thanks for the clarification . Reply @edmondnoir6191 @edmondnoir6191 1 year ago I'm 35 and trying to start young to buy myself 10 years of healthy living at the end of my life. I am 10 years older then my S.O and I want to maximize my life and quality of life with her. I hope I can buy enough time to live as long as her. Reply @amys5420 @amys5420 11 months ago My Indian grand father lived for 107 years in a small village as a poor farmer. Reply @robinharrischapman9802 @robinharrischapman9802 11 months ago So I do short and medium distance triathlons, how do I eat less often when I need to eat to fuel my training and to use carbs/sugars during for long workout/races? 1 Reply @carlogaytan7010 @carlogaytan7010 8 months ago How about proteins from Legumes, and Soy. This seems to me that goes well with a plant diet, it has fiber and fills you up too. Reply @weinazhang2529 @weinazhang2529 1 year ago You two are working perfect together! I’m a big fun and exciting I actually living the life style as you suggested in last 10 years. 4 Reply @nathangarnham5467 @nathangarnham5467 7 months ago im confused. I thought having muscle tone was one of the strongest predictors for longevity and now I get the impression i should stop eating so much protein Reply @rdkuless @rdkuless 10 months ago Longevity is not important if you are not in good health.. I've outlived my prognosis of dying before the age of 15.. I'm now age 57 and limited by multiple healthy factors that make life painful constantly.. Without your health, you have nothing. I would have rather lived 1 year with great health, rather than 100 years of pain.. Reply @justinbyrge8997 @justinbyrge8997 1 year ago So what constitutes as adequate nutrition? Are recommendations from the myplate website considered adequate? Cause if it is, I'm wondering how the heck to get all that food in an 6 or 8 hour window of eating when fasting for 16 to 18 hours. For example my recommendations according to this site is as follows: 2 cups fruit, 4 cups veggies, 8 oz equivalents grains, 6 oz equivalents protein food, and 2 cups milk. If I'm eating in an 8 hour window, that's an awful lot, especially from the grain group. I've watched many talks with Sinclair and he is always vague and ambiguous. So could you be more specific to the example I've provided? Thanks Reply @dallyh.2960 @dallyh.2960 1 year ago (edited) This reminds me of Lucy. Professor Morgan Freeman said something along the lines that organisms that exist in a safe environment of abundance choose sexual reproduction to pass on their DNA through time, while organisms in hazardous and extreme environments choose immortality. Movie was cool overall, it did use some stupid pseudoscience here and there but I still was able to enjoy it. Reply @deborahmartins4137 @deborahmartins4137 1 year ago Can Type 1 diabetes be reversed? I was diagnosed with T1D at age 34, that was 20 years ago. Reply @shambhavipathak2581 @shambhavipathak2581 1 year ago I’m a 24 year old female from India and have been fasting for past one year but my lab results this time shows that I am diabetic. Now how do I manage this condition along with my fasting regime because the doctor asked me to eat something or the other every 2/3 hours. Also, I’m a vegetarian. P.S. Lots of love from India, Dr.Sinclair. You’re doing great work. Huge fan! 3 Reply 2 replies @nodster7778 @nodster7778 8 months ago How many grams of protein do you recommend a day? I've been doing. .75-1 gram per lb of body weight Reply @ginkgoway8165 @ginkgoway8165 1 year ago Hello doctor, I have been on one meal a day for almost a year but not losing extra 20lbs I have gained after menopause. I always been eating small and still eat small. Also am active. Just wanted to say that everything that works for men and women before age of menopause does not work for menopausal women. Reply 2 replies @susymay7831 @susymay7831 1 year ago (edited) Older people often get too little protein. But how much protein and where should we get it from? Reply @hub8075 @hub8075 1 year ago I loved your podcast 1 Reply @beverleycumming1876 @beverleycumming1876 8 months ago I rarely eat beyond 3 pm…I eat a meal and sometimes a snack within 4 hour period Reply @Boriskbjj @Boriskbjj 1 year ago Such interesting content! I have a question… When sick with a cold or flu for example, my parents would always try to encourage me to eat in order to keep up my strength and help me fight the illness, but listening to the podcast leads me to believe that the lack of appetite when sick is an intended side affect to assist the body in healing itself during a ‘fast’ Can you shed some light on this? Should we force feed ourselves when sick or is it just fluids which are important? 10 Reply 8 replies @Toxic-tm8ep @Toxic-tm8ep 11 months ago Does plant protein also decrease lifespan? Or is it only protein from meat? 1 Reply @marlinspike @marlinspike 1 year ago So what was the deal with fructose? Many of us drink smoothies on an empty stomach, I was under the impression that fructose doesn't spike blood sugar like glucose Reply @grant9047 @grant9047 2 months ago fasting is really hard smh I'm so used to eating breakfast lunch and dinner at certain times Reply @kingdom8474 @kingdom8474 1 year ago Question, does a smoothie count as a meal? Pineapple, peaches, strawberries, cucumber, watermelon, spinach, and beet powder ingredients. Reply @freespiritwithnature4384 @freespiritwithnature4384 11 months ago I have incredibly high heart disease, and people die young from heart disease in my family. My father died at 68 as did his mom ,my grandmother. I decided to get a heart surgeon and he’s 100% against keto . He asked me to watch “ Forks Over Knives on Netflix “ . Would you recommend someone take NMN and reservatrol on top of taking Nitro Glycerine ? If my mom leans forward she feels a squeezing in my heart . She’s 62 . She used to be heavy smoker but quit 7 yrs ago. She doesn’t drink,but she does have fibromyalgia and CRPS. She started taking 81 mg coated aspirin a day. She eats one meal a day and doesn’t eats meat 4X month. She’s blood type O positive. She began to get strange pressure in the head ,forehead. A pressure type headache. Her BP is ok but I’m wondering what is best , NMN reservatrol and Nitro ,or a 81 mg aspirin a day? Even though she does eat healthy,she’s still overweight by 45 pounds. Do you think one should lower calorie intake? Now I’m hearing people say eat nothing but meat to reduce your chronic pain . I feel better on plants beans vs meat. Is it better to take B12 or eat red meat 4 X month ? What brand of NMN and reservatrol do you recommend someone age 62 begin with? I heard that Cancer Patients don’t have any Coenzyme Q10 . I hear Dr David Permutter saying that uric acid levels are important. Mine is 3.3 .He’s saying under 5.5 uric acid . Thank you so much for your research.❤️🇨🇦 Reply @brendasteele4014 @brendasteele4014 1 year ago LOVE this podcast. Please continue! 3 Reply @leonardosemedocoelho7479 @leonardosemedocoelho7479 2 months ago Hello Dr. David Sinclair, Dr Satchin Panda says coffe breaks the fast. My first meal is about 13h30 and my last meal at 21.00, But i do take a coffe (without sugar or milk) arround 8:30 in the morning. Does that breaks my fast or not? Am i having the same advantages for my health? Thank you for your time. Leonardo Reply @maryshi4210 @maryshi4210 1 year ago I’m avoiding all added sugars and conventional desserts like cookies, cakes, etc., but what about fruit? Is one piece of fruit at the end of a meal acceptable or will it also spike my glucose levels? Reply 1 reply @humairaziauddin5382 @humairaziauddin5382 2 months ago When i fast in Ramadan I always lose weigh and my diabetes came down . 1 Reply @jmarty1000 @jmarty1000 10 months ago I always remember "Hunger is 100% Natural" 1 Reply @yanzhuji @yanzhuji 1 year ago very educational Reply @steviejacko @steviejacko 1 year ago I only eat on Saturday and Sunday now the rest of the week I fast water only . Life is so amazing I don’t have to worry about deciding what to eat during the week which frees me up to do so much more . I’m 62 and now can run better than I did 30 years ago and I look 20 years younger 16 Reply 3 replies @WorldAquariumSingapore @WorldAquariumSingapore 1 year ago In one day Eat Breakfast, Eat Lunch and Skip dinner and with no supper, will this routine work? and how many days in a week should i follow this eating routine if the above is correct? Reply @carlamurphy7541 @carlamurphy7541 1 year ago Hey ..I'm going to take my chances with this diet ..I mean if David Sinclair can look two decades younger than he actually is...I'm in. Reply @MB-xu5kd @MB-xu5kd 8 months ago Good interviewing Matt LaPlante! Reply @yomarybaquero1814 @yomarybaquero1814 11 months ago How do I ensure that only with one or 2 meals per day we cover all the nutrients? Must we take supplements? also if you are getting old (example 45 years old) is there are a minimum protein requiermenra to keep muscle mass. how to keep eating just one per day? Reply @ildevaniosoares @ildevaniosoares 5 months ago wonderful video! thank you ! Brazil Reply @AhmedBodhi @AhmedBodhi 1 year ago I'd love to hear what you've learned from more intense water fasting / dry fasting periods (2-7 days). 8 Reply 1 reply @Martin-bk3sp @Martin-bk3sp 9 months ago Is it easier for the body to reach the fasting mode when de food is plant-based? Is it the same 12 hs of fasting for a Plant-based diet as the 16 hs for a meat-based diet? Reply @joannajanickajaworska3341 @joannajanickajaworska3341 7 months ago I love it, David. Reply @romeoline1174 @romeoline1174 1 year ago Merci....mettez nous des sous titres en français.......nous aussi on ne veut pas vieillir Reply @p3shitonlin3 @p3shitonlin3 8 months ago Thank you Dr David for the amazing podcast. However it would be much better if the host doesn’t interrupt too much while you’re speaking. Reply @zerokool2575 @zerokool2575 1 year ago What if you’re somebody that has to eat multiple times a day just to keep from losing weight and not be malnourished? Reply @RamssesPharaoh @RamssesPharaoh 1 year ago Thank you so much; for all your work and for sharing your knowledge and wisdom with us. 3 Reply @devorahacts @devorahacts 7 months ago But when you talk about little women getting old, you may have missed something there. Sometime between age 70 and age 80 women's hormones change again and many of them lose weight. So anything hormonal that might have been imbalanced in middle age that problem tends to go away. So unless they're eating some abnormally awful things, they're going to have a fairly good weight. Reply @SpodyOdy @SpodyOdy 1 year ago So muscle building approaches strength athletes, Bodybuilding, athletes in general etc. use when it comes to diet to do so are basically the opposite of what is good for longevity? What should a athlete do to be the best athlete they can while still working to increase longevity? Reply @biomedtube3479 @biomedtube3479 11 months ago hi, Dr. David Sinclair I am Siva rama prasad researcher working in regenerative medicine, my project aim is the in-vivo application of embryonic molecules to rejuvenate and regenerate different organs, in the first phase of clinical trials I have successfully crossed immune and inflammatory barriers and now I am continuing my study Nephrons regeneration in different CKD models, we got exceptional results in drug-induced (NASID) in small rats group, we planing to extend our study in large group, for this we are searching for a funding agency, can you please help me. Reply @michalwojcikiewicz6326 @michalwojcikiewicz6326 7 months ago (edited) Trying to gain muscle which means I have to eat 3500 calories. My issue is i can't eat a single meal to fulfill this calorie intake and my body can only absorb 30 to 40 g of protein per sitting. Wonder how I can build muscle and still obey the rules of fasting Reply @manuelavelosojr.m.d.5785 @manuelavelosojr.m.d.5785 1 year ago At what age would starting calorie restricted diet be helpful? Reply @andrewblessing355 @andrewblessing355 1 year ago Thanks Dr. Sinclair for all this great information! I've followed you on many other podcasts and am excited you're doing your own! Question: I love Athletic Greens and have been using it for years. You mention taking it in the morning. Does it not break the fast? I use it to come out of my fast, but would love to have it be during the fast if it doesn't break it. Thanks! 8 Reply 1 reply @jonathanmagic5633 @jonathanmagic5633 9 months ago After several decades of working in Health I've noticed that people who are small & slim individuals seem to live the longest by quite a margin and that's regardless of nationality. Reply @a.d.7922 @a.d.7922 1 year ago even though you have very strange looks your information makes great sense.thank you for posting these videos. Reply @Michael-4 @Michael-4 1 year ago (edited) I have a question about diabetics. Their risk to health can be majorly reduced by going keto and doing IF. If they adopted your diet wouldn't the benefits be negated by higher blood sugar. To get the plant based protein would come higher carbs. Is it possible to remain in remission using your high plant based diet? Reply 1 reply @Toxic-tm8ep @Toxic-tm8ep 11 months ago Is MTOR only affected by meat protein? Or it is also affected by plant protein? Reply @Coilygirl1 @Coilygirl1 1 year ago How do I gain muscle by eating less? That's my concern. It makes sense not to work my internal organs as hard. Reply @Fritz.program @Fritz.program 1 year ago I am an Olympic weightlifting coach and have been chasing performance, strength, and muscle mass gains for most of my adult life. I am currently in the midst of a transition where my intention is now focused on longevity, largely due to learning from Dr. Sinclair, Andrew Huberman, and Robert Sapolsky. THANK YOU!!! It sounds like we can’t have our cake and eat it, too: chasing competitive performance/strength/muscle mass burns down the longevity wick. Follow-up question: - where are the amino acids derived from for gluconeogenesis? 3 Reply 3 replies @privateerburrows @privateerburrows 8 months ago (edited) 1:08:05 One terrible mistake: "Eat your sugar at the end of your meal" ... it is true that doing so will spike insulin less, but the reason for that is NOT auspicious in the least. Our stomach has the ability to absorb sugar-water (fruit juice) when fruit is eaten alone, in an empty stomach, the way fruit was meant to be eaten; but when your stomach is digesting protein, and is full of enzymes and hydrochloric acid, it cannot open its pores to absorb sweet juice. Thus, when you eat fruit or sugar with a protein course, the sugar is not absorbed quickly through the walls of the stomach as it should, and instead it ends up passing on to the intestines, where it wrecks havoc with our intestinal flora ecology. The time to eat sugar, if any, is when the stomach is empty, at least 4 hours after one meal, and at least 30 minutes before another. Skip dessert is as important as skip breakfast. Protein and sugar don't mix well. 1 Reply @alejandroguerradiego1931 @alejandroguerradiego1931 9 months ago Congrats David! Amazing work. Do you know a similar service like Inside Tracker in Europe? Reply @dapawap @dapawap 1 year ago What about us in Australia? I was interested in levels but found it only applied to those living in the US. I am interested in my health & living a very long time. Please organise levels to include Australians. Reply @tumadre69727 @tumadre69727 1 year ago One very old man in his late nineties said his secret to longevity is push away from the dinner table hungry. And he resembled a stick figure. But his "diet" included whatever he wanted to eat. Reply @amandaaussie-at-heart2735 @amandaaussie-at-heart2735 1 year ago I'm starting to doubt whether i should have breakfast .. got a bad headache today .. ate teff at breakfast. Also, I'm not sure if plant-based is right for all genetic types. Reply @simranbali7431 @simranbali7431 1 year ago (edited) Thanks for sharing science based knowledge! I have been reading mixed information regarding fasting impacts on women. Especially if this may disturb women hormones. Do you have any information on the best protocol for women? 3 Reply @kristydickerson6171 @kristydickerson6171 6 months ago When you talk about eating meat-red meat- do the studies differentiate between grass fed/finished meat and pasture raised meat vs. feed lot meat/pork/chickens? I know that is makes a difference because the fat profiles are different across the board. Reply @louise6625 @louise6625 8 months ago I have a question. If going to one meal a day and drinking coffee and tea .. does it matter if milk is in the tea and coffee? Reply @potentnaturals188 @potentnaturals188 1 year ago During fasting so theres no food in the stomach.. will long periods of having an empty stomach cause damage to the stomach lining since the stomach will continue to work even if theres nothing in there? Reply @millermilena @millermilena 6 months ago Most people myself included have some gastrointestinal problems (+ I have a liver condition), doctors say it’s not good to fast for us. So should I just die young?😅 Reply @colm5516 @colm5516 1 year ago Good day David, I’ve been listening to you on and off for a few years, I’m on the Goldcoast Australia, Can you recommend a good lab for me ? Thank you Colm Reply @Basican_pro @Basican_pro 1 year ago Thank you so much for sharing this with us! I’d very much like to also hear your thoughts about ASD, Dr. Sinclair. 1 in 44 children in the U.S. is diagnosed with an autism spectrum disorder (ASD) and this epidemic is global. There is no known single cause for autism spectrum disorder, some say it’s genetics, some say it’s environmental. most children have gastrointestinal, mitochondrial, sensory issues, inability to detoxify and the list goes on. These kids are born with ASD. Please share your thoughts on this disorder, is this related to early aging and can we fix these so called “dirty genes”. As a mother of an autistic 3 years old child, I’m eager to learn more about this and help my child as much as I can. 9 Reply 9 replies @steveneverett8148 @steveneverett8148 1 year ago To the hosts, what about meat on weekdays, no meat weekends? Or maybe a two day fast once a month? Trying to keep meat in the diet most of the time but still trigger autophagy regularly. What would you suggest? Reply 1 reply @tanyalove6983 @tanyalove6983 8 months ago To follow up I just looked up who has the longest lifespan according to their BMI. If you are below the recommended BMI and are anorexic you have the shortest lifespan even shorter than the obese people probably because your hearts muscles are reabsorbed and your bones are brittle. Surprisingly the people who lived the longest were in the normal range during their mid life and were in the overweight category in their later years. So this seems to contradict what Dr Sinclair is saying. How do you respond to the latest study called the "obesity paradox" . Perhaps in later life happiness and lack of worry about your weight is the most important factor and as you age you need to eat more to absorb more nutrients so being active and happy and eating more seems to extend the elderly persons' life. The facts seem to completely contradict what Dr Sinclair is saying. How can Dr. Sinclair contradict the obesity paradox???? Reply @dollyvandenbrink5211 @dollyvandenbrink5211 1 year ago Dr Sinclair. I’m on Metformin cuz I’m Prediabetic since the last 7mths & I’ve Already 10kilos But I wasn’t Really Over weight anyways. I’m 5ft 7” inches & was 85kilos. So Now I’m 75kilos. I’m Trying to Do Intermittent fasting with Lunch & Dinner. Please let me know if it’s OK for Diabetics 2 to Do Intermittent Fasting in Holland & thanks Reply @nicangel2007 @nicangel2007 1 year ago Why not to take Flush Niacin and TMG instead of NMN? I am just getting into the subject through experience and I am wondering because Flus Niacin and TMG gibes me so much energy and makes me lose weight quickly, it feels really rejuvenating. Reply 1 reply @simply_nd_a @simply_nd_a 1 year ago I'm curious about fruits? Can you please share a video on fruit . Is it good,bad, how much,if any? Reply @Thundercloud1969 @Thundercloud1969 1 year ago A lot of things make sense, as I have been reading up on the subject for my job. Yet, our DNA is different in a lot of ways than that of rodents. For example, there are Alzheimer tests that had a positive effect on mice but not on humans. And tbh, although I think David is a great scientist, he also is a business man. It would be great to not say anything about supplements in a video but just share info about the topic longevity but that's my opinion. Thank you for sharing, I thought it was very interesting. 8 Reply 1 reply @user-ke6yi7dm3f @user-ke6yi7dm3f 2 months ago What is your opinion on consuming fruits? regarding high sugar content 1 Reply @filipbalun71 @filipbalun71 9 months ago Doesn't AG1 break your fast if you drink it in the morning? Reply @linaaboudheir3878 @linaaboudheir3878 1 year ago Amazing discussion Thanks sooo much Love & Light from Kuwait Reply @bogse @bogse 2 months ago Many Okinawans train karate and the benefits of karate for lifespan are probably huge. Not sports karate but real karate. Reply @Izanagi_0 @Izanagi_0 4 months ago Should I fast even if I am underweight? Reply @christopherschwab3934 @christopherschwab3934 1 year ago (edited) David - I would love to see you talk about the ancient traditions and their take on longevity - the Daoist alchemists, Yogic ascetics and so on. It's a fascinating thing because so much of what they said thousands of years ago is mapping perfectly onto cutting edge research today. (I'm not advocating an esoteric approach here because hey...they did also advocate some insane practices like mercury ingestion, just pointing out how interesting it is) 22 Reply 4 replies @powerguiller @powerguiller 1 year ago Dr. Sinclair should have mentioned the benefits of ketosis, since fatty acids activate AMPK. Reply @napnap609 @napnap609 1 year ago If you only eat once a day, but are burning 1500-2000 calories a day then you'd need to eat 1500 + calories in one meal. I suppose that's doable, but it seems eating once a day for an active person will have them continuing to lose weight until they're skin and bones. Reply @gregcleveland8806 @gregcleveland8806 1 year ago Will AG1 drink break my morning fast? I love it first thing in the morning, but am also trying morning fasting? Thanks. Reply @MegaAnufriev @MegaAnufriev 1 year ago Isn't it better to have one big breakfast? This way you have enough energy to work, workout. Reply @lelle9901 @lelle9901 1 year ago This guy was born in 1969. He looks here like he is in his 30s. In fact, he looks younger than in his older videos. Food for thought. Reply @therockinguitarman @therockinguitarman 1 year ago By far the best anti-aging health lifestyle information available on YouTube 💡 11 Reply 2 replies @argyropikou6813 @argyropikou6813 9 months ago Thank you and keep on smiling!!! 1 Reply @elsierussell2626 @elsierussell2626 1 year ago (edited) HMMM. Well, I almost died on a vegetarian diet, doing "what was best for my health". At 30 I was diagnosed with MS, (unable to extract B vitamins, so very depleted, with a compromized gut, not to mention paralysis. So, I restricted more as my "expert" doctor's ordered, and got much, much worse. Some might epigenetically be able to adapt and thrive on this plant based "longevity" protocol but not me! I reversed this horrific situation on my own, and for years now, have been doing 16/8 IF or more, (never for weight, as anaturlly "underweight" mesomorph.) I eat mostly meat, eggs, fatty wild fish, and animal fat to feed my mitochondria and nervous system, limiting carbs/plants to -20g/day. At 65 I still look 20+ yrs younger and am an active sports and yoga practitioner. No more arthritis in my wrists or hips, wounds heal in days, with mental clarity sharper than in university, and I am happy! I would love to believe your scientifically "proven" dogma, and I do believe in science 100%, but anecdotally, I have to say NO to this. My quality of life matters more to me than its length, maybe? 1 Reply 2 replies @robertcamp233 @robertcamp233 1 year ago One meal a day is my goal 👍🏿 lower my blood sugar and lose weight Reply @sarrormiki3363 @sarrormiki3363 1 year ago Do you track the vitamins and minerals you get somewhere? Other than bloodwork. Like cronometer etc. Like what do you actually eat? Can we get an example? Reply @jubansisohsten4019 @jubansisohsten4019 1 year ago Wt abt me Dr? I can't do fasting as I feel hungry and if I late for food then gastric occurs... I am 38+ female and my weight is 53-55 kgs. I am prone to allergic reaction every now and then, any suggestions... Thank you 😊 Reply @gihango @gihango 1 year ago Thank you for this podcast, as a person who grew up on mostly plant based diet in Africa, I can testify to the fact that we do not need as much of animal food source as we need. I’m going to share this info with as many people as I can. 5 Reply @dfitnis @dfitnis 1 year ago Have you looked at the restricted eating in individuals who are very active-like 1-3hrs a day. Athletes? find it hard to have enough fuel to sustained high intensity exercise? not sure if this is going off the course of longevity.. just very curious? Reply @arxmechanica @arxmechanica 3 months ago Hemp seed has the highest amount of usable protein of any food source (more than meat) and contains all nine essential amino acids, plus fiber, healthy fats, minerals, and antioxidants Reply @alexpeikary @alexpeikary 1 year ago Thanks for the good information, stay tuned and good luck........................ Reply @jakobw135 @jakobw135 11 months ago Isn't it better to eat two meals a day starting with breakfast and ending with dinner? What about the saying: eat breakfast like a king, lunch like a prince, and supper like a pauper? Reply @richardholland622 @richardholland622 1 year ago Hi, I am looking to intruduce MNM and Resveratrol to my daily routine and after doing a small amount of research there appears to be a mindfield of companies selling products with little to zero mnm, is there a reputable third party i can cross reference product claims? Thanks Richard Reply @javiergarcia7807 @javiergarcia7807 1 year ago Really thanks for sharing this information with the world! You always talk about vegetables. I guess you eat the more xenohormetic ones and potatoes to control blood sugar, but could you talk in one episode about what concretely you have for dinner? 3 Reply @ashaamara6912 @ashaamara6912 1 year ago I think this information is useful, however the price tag for all the supplements is not practical for the average individual looking to improve their life. I found the list of Dr. Sinclair's supplements and if you include Athletic greens it is almost $500....this doesn't include the perscriptions. Is there a basic supplement list that a normal person could afford and benefit from the anti ageing benefits?? Or is it the case that the diet & lifestyle changes constitutes the biggest source of antiageing benefit?? Reply @rnancyp7986 @rnancyp7986 6 months ago can't figure out, if OMAD is good then doesn't a large meal spike your insulin? isn't that bad for A1C? Reply @cynthiatrahan @cynthiatrahan 11 months ago After losing 45 pounds does eating less in a small window help with lose skin? Reply @zioncityofgod4818 @zioncityofgod4818 7 months ago In the mountains of Oaxaca, Mexico, one can find 99 yrs old couples farming the land. When asked what they eat, they always answer LEAVES, VEGETABLES, ESPECIALLY CACTUS, FRUITS, TORTILLAS, AND DRINK WATER FROM THE MOUNTAINS. SINCE THEY LACK MONEY, NEVER EAT MEAT. Reply @gogigogi8835 @gogigogi8835 1 year ago This episode really made me hungry. Went to eat something Reply @D51000 @D51000 1 year ago Thank you so much David for all this information 😊 12 David Sinclair Reply @jasonhenderson5879 @jasonhenderson5879 6 months ago If a bit of adversity (fasting, cold water, hot saunas etc) is good for us, then why doesn't that theory work with sleep? ie, doesn't missing a night's sleep now and again trigger the same 'adversity benefits'..!? Reply @quantumflux000 @quantumflux000 11 months ago ♥♥♥ amazing follow up! Reply @hc9848 @hc9848 1 year ago Is oatmeal bad to eat by itself since it is a carbohydrate? Reply @Gumballa87 @Gumballa87 6 months ago "[Giving children food at all times] is setting up their epi-genome for feast not famine" - so is there a link between a kid not knowing what sweets or sugar for that matter was until age 5 because of skin issues and that kid later being one of those "can eat whatever, I will not get fat if my life depended on it" types? what an insightful day .. Reply @guravi4295 @guravi4295 5 months ago if this works, I will be looking up this guy in the year 2150, and say thanksgoodvibes Reply @denisecoates2015 @denisecoates2015 1 year ago Thank you for sharing your vast knowledge base. Please can I ask a question. I’m post breast cancer 6 years (A hormone based breast cancer) . My post treatment is a tablet called Anastrozole snd currently I take it in the morning after some food that’s lined my stomach.. I really believe in the intermittent fasting but only skipping one meal. I do exercise and I’m adopting a plant based med diet…Is there any other advice you can give me? Thank you. Denise 🎀 4 Reply @debbiem6637 @debbiem6637 9 months ago Wonder what is the best resveratrol I can take and can I open the capsules and mix it in yogurt? Reply @Monstrinho35 @Monstrinho35 6 months ago Among others, i have two doubts. The first one, and i never saw anyone talking about, is if you can eat your veggies cooked like in a vegetable soup. I eat it almost every day. The second one is about fasting. You say you skip breakfast but at the same time i eard you prepare yourself a drink with the supplement you publicity. That doesnt count? A veggie smooth for example doesnt count when you are doing fasting? Thank you to anyone who can help me. Reply @hayateaxel5380 @hayateaxel5380 11 months ago Can a 25 year old start with intermittent fasting? I'm having a proper bmi too. Reply @bushwhackeddos.2703 @bushwhackeddos.2703 1 year ago I eat pie n mash every week and have done at the same pie shop for 50 years, since I was a baby. I like pie 👍 Reply @deepikabajaj @deepikabajaj 1 year ago around 49:30 - Dr Sinclair talks about pesto-vegetarians having highest uptick in mortality compared to non-vegetarians (assuming that is red meat), where can I get more elaboration on this diet? Is there a correlation to texture, e.g. include other seafoods, shrimps/prawns that are texture-wise similar to fish... Reply @Irene-po5kp @Irene-po5kp 1 year ago Love the podcast. Thank you for all the information. I have been following Dr. Sinclair for years now and never before heard him say anything about athletic greens in the morning. It always has been just coffee, yogurt/olive oil with supplements. I am just looking for confirmation, because it seems that a cup of athletic greens should break the fast. Could you please provide more information on this? Thank you. 3 Reply 1 reply @johnwilkins3995 @johnwilkins3995 8 months ago (edited) When you fast, you kind understand slowly why Jesus did it. You also realize how often you typically eat when not actually hungry. Reply @nonamenoname8165 @nonamenoname8165 1 year ago The guy in glasses looks kinda goofy but he is actually contributing, well done Reply @theojan1 @theojan1 1 year ago When eating for example a banana at a moment during the day when you should not be eating, you are fasting, does that ruin the entire cycle ? Reply @francescaschoice2892 @francescaschoice2892 8 months ago Dr. Sinclair, great episode, you’re extremely knowledgeable and helpful. Please though cut out the co-host, he didn’t say anything insightful and only cut you off or tried to make fun and or minimize you at points. He’s terrible. Reply @racecrashrepeat @racecrashrepeat 11 months ago (edited) Hi, I doubt you'll even see this comment. My wife and I have been fasting and love it but a friend of mine is telling us it's very bad for women trying to get pregnant so now we are worried. Is this something has come up in your research. We are 40 currently and follow your recommendations and have been for a few years but just worried about the pregnancy partas we are trying for a child. Thank you. Reply @patricialovesmovement5659 @patricialovesmovement5659 1 year ago Thanks for all of this info! Are fermented veggies more bioavailable than unfermented? 3 Reply @davidsetliff8581 @davidsetliff8581 1 year ago Continuing to call this a "diet" is why ppl fail - they think it's temporary. As David suggested, it's a lifestyle change, not a diet. Do it forever. 1 Reply 2 replies @rodneyhill299 @rodneyhill299 8 months ago If you fast you can eat a pizza guilt free every day (but of course get your vegetables in) Reply @justno9342 @justno9342 1 year ago is this strange to observe that whenever i induce consciously the feeling of hunger, the sensation of it comes from my stomach only or that part of my body? its never like that before but there was this one period of my life whence i was reaaranged energetically. strange to say. i know.. even now i dont have any inkling where it came from Reply @kimberlyperillo9990 @kimberlyperillo9990 1 year ago Does Atheletic Greens break your fast? Do electrolyte powders with magnesium, potassium, and sodium and showing 1g carbohydrate break your fast? Reply @taomahNEGEV @taomahNEGEV 1 year ago 1.: According to present medical studies and the medical Diabetes diet eating 5 times day is healthier than eating once or twice a day. 2.: According to a study published in the Guardian "less than 40% calories from carbohydrates carried a higher risk of mortality". Reply @toms6464 @toms6464 1 year ago Thanks Dr. Sinclair. A question that will likely resonate with a part of your audience. Theoretically - how would an athlete, with a higher requirement for protein intake incorporate the longevity framework you've proposed in terms of reducing meat / BCAA intake? 4 Reply 3 replies @gregory2421 @gregory2421 1 year ago So I guess building new muscle is out of the question if you want to live longer Reply @alexforce9 @alexforce9 11 months ago People seems not to understand what mTOR is and why its good/bad. mTOR is great if you wanna build muscle or when you are growing - like a kid or puberty. The problem comes if you are siting on your ass all day and then eat something that activates mTOR. You must deserve your protein. And muscles are good. There is a correlation between lean muscle mass and longevity. Reply @travislibby9930 @travislibby9930 10 months ago Does Athletic Greens break a fasting period? Reply @GravefriHave @GravefriHave 1 year ago 🍷 cane w short spur / Cordon training some will pull the lower leaves (basal leaf removal) in order to expose the bunches of grapes more 🍇 More Sune => more tanned skin color This will also stress the grapevine plant and improve the immunesystem .. plus other technics but this we talk about another day Reply @richricogranada9647 @richricogranada9647 1 year ago Shortness of food is going to be a very good thing. Reply @cashglobe @cashglobe 1 year ago Great podcast! I’m someone who loves bodybuilding and powerlifting, so I don’t want to sacrifice muscle gain. Is there a way to optimize longevity/anti aging while still eating a significant amount of protein? 5 Reply 5 replies @shirleywilton8122 @shirleywilton8122 7 months ago Drinking too much coffee for me causes me stomach issues and it’s not good for gut health. Water is a good idea but not everyone can handle so much coffee or tea. Reply @bellagdur9786 @bellagdur9786 11 months ago Dr.sinclair, can you tell us how much is not too much protein (g/ body weight). Im very confused with all the information out there and i have not found the answer from all the interviews you have given.. Your response would be very much appreciated. Thank you. Reply @lirivicerabin3682 @lirivicerabin3682 1 year ago Please be very careful with this information if you have or have had an eating disorder. This could be so dangerous. Reply @garysbraccia4980 @garysbraccia4980 10 months ago So if you drink athletic greens in the morning is that still considered not eating or breaking your fast???? 1 Reply @k.h.6991 @k.h.6991 7 months ago For those who want to do the Mediterranean diet: do look it up. Don't just do your idea of it. Reply @paulbenoit8842 @paulbenoit8842 1 year ago Thank you for sharing this information! A question; When you say limit 'super high protein' can you suggest a % range of an individuals calories as a starting point? 7 Reply @Sharperthanu1 @Sharperthanu1 1 year ago Potatoes should be as bad or worse for spiking your blood sugar than white rice.A good replacement for potatoes are sweet potatoes and a good replacement for white rice is brown rice. Reply @NEdumpling @NEdumpling 1 year ago Say if i do one meal a day, for that one meal do i stuff myself to make sure i get enough calories? If i eat a normal one-meal portion i risk losing weight, which is very bad because i'm underweight, but if i stuff myself that can't be good either can it? i don't see doctor sinclair talk about this in any of the videos that he talks about omad, probably because he assumes nobody minds losing weight. i wish that when people talk about healthy lifestyle choices they address the problems us underweight people face as well, not just the ones overweight people face. People automaticly assume skinny people don't get health problems - not true - i'm underweight because i have a very poor digestive system. In fact i think my problem is a bit trickier. anyhow i'm still very grateful to have come across this video, it is immensely enlightening! 1 Reply @robertval8196 @robertval8196 8 months ago Understood, low sugar so obviously avoiding candy and refined sugars is good. What fruits are acceptable with this dieting regimen if any? Reply @miiitchhh225 @miiitchhh225 1 year ago David, throughout the podcast you say you’ve never ate breakfast and that you only drink coffee and tea, and a spoon full of yogurt for your supplements. But then during your plug for athletic greens you mention drinking it in the morning. Can you clarify? Reply @francissoriano2217 @francissoriano2217 1 year ago Will athletic greens break a 18 hour intermittent fast? Reply @YEE087 @YEE087 1 year ago Thank you David for another great episode. Just wondering about this for a while now and you have actually mentioned it. A scoop of athletic greens probably has around 50kcal and they also say it does "break the fast". If you take it in the morning, do you think that has a negative impact on the fasting cycle? 5 Reply 2 replies @poolpumped1364 @poolpumped1364 7 months ago (edited) How does proper hydration affect longevity, if at all? We are in fact mostly made of water, so it would seem water is essential not only to all life forms, but also with health-span and lifespan. Reply @dailybibleverses4903 @dailybibleverses4903 1 year ago Nuts are too allergic. Not good for many people. Also you are not taking into account and it’s crucial in eating is parasites and contaminants. Reducing them is also very important. The good thing about fasting also is that it will help your body get rid of them. Also, there is corn syrup fructose, and there is fruit fructose, fruits are good for you, because of the vitamin and other nutrients content. Reply @pb25193 @pb25193 3 months ago With all due respect sir, the playlist is not in sequence. However, I'm able to navigate thanks to your episode numbers on the title. It will be even more useful if the #1 or #2 is in the starting of the title Reply @Allioops810 @Allioops810 7 months ago I am completely on board with everything that was said here up until he said that we have to go back to when people were cold and hungry. I don’t think they lived long lives back then. Reply @andreic1755 @andreic1755 1 year ago I am 30 and I want to live longer probably I will be enough lucky that in 40 years they will discover how to stop aging and then how to reverse it. This way I might be immortal. Reply @InfinityChris @InfinityChris 1 year ago I agreed with everything until the meat part. Fish is higher in TMAO’s than beef, yet is supposedly healthier. As a type 1 diabetic, meat blunts my hunger, keeps the blood sugar extremely stable, and has effectively improved my health (no acne, lower A1C, better and more stable energy, allows me to fast LONGER and makes me less hungry, has helped my vision get “better”/less blurry, less brain fog, helps improve my performance as a runner and weight lifter). The problem is people combining meat with carbs. If you’re eating a steak, don’t have soda, fries, or bread with it. Just eat the steak. If it isn’t enough, eat more steak. Just don’t have it with the carbs, and put your focus on whole foods. 8 Reply 4 replies @RogerEdwards1214 @RogerEdwards1214 8 months ago Lol, even Dr Sinclair is like “1 day is hard enough, basically anything longer, I ain’t doin that sh-t” 😂…NMN is incredible btw! Buy from Renue, it’s the cheapest I found. I bought another brand & it wasn’t even NMN or it was expired (waste of 💵😢) Reply @sues4370 @sues4370 9 months ago What about lectins? I've read elsewhere that we should avoid foods that have them. Reply @WastefulMedia @WastefulMedia 2 months ago coming from a working class family im gonna live forever: - there's never food in the house - we cant afford the heating - veg is cheap and abundant where im from - sweets are costly - im from the uk so theres little sun Reply @cynthiaktaylor5585 @cynthiaktaylor5585 1 year ago Does Athletic Greens use organic greens only? That’s my fear with using them…concentrated pesticides… Reply @danilkopaskudnik3002 @danilkopaskudnik3002 1 year ago Any relation to Upton Sinclair the writer ? He was big proponent of fasting .. loved his book The Jungle .. Reply @kostas.dino31 @kostas.dino31 1 year ago So thankful for this podcast! 6 Reply @sevgindilek7813 @sevgindilek7813 7 months ago Hello Dr. Sinclair, what about women doing intermittent fasting? Various professionals say hormoneswise it can be dangerous. Is that true? Reply @WeaponGrade @WeaponGrade 1 year ago I wished you had compared meat vs poultry vs fish . Are they all equally bad in terms of mTor reaction? Reply @markd6838 @markd6838 11 months ago Great stuff Reply @balasubramanik4163 @balasubramanik4163 1 year ago This is what we Hindus in India follow .Hinduism shows the way for Longevity through Fasting methods and all our women, especially fast on Fridays and Saturdays Reply 1 reply @fahmomohamed9713 @fahmomohamed9713 1 year ago Thanks for good note you are awesome Reply @beereeet3950 @beereeet3950 1 year ago (edited) Awesome David!! Thank you!! Can I ask for more information on longevity and muscle; is it okay to stuff in enough calories and protein in the small eating window and maximise mTor during this time? Or is there really no way to maximise muscle and simultaneously living as long as possible? Thanks again!! :) 3 Reply 3 replies @annewilliams9279 @annewilliams9279 1 year ago Thanks Dr. Sinclair! I noticed one cost-effective NMN brand for me, it's Vitruvin Nutrition..😍 Reply @Whale_Games @Whale_Games 1 year ago I don’t know if what David does is considered really fasting for the simple fact that a couple of spoons of yogurt he has to mix his supplements do have calories and then in turn spikes his glucose and in turn break the fast- what he’s doing is basically one meal a day but not a 20 hour fast to my knowledge. 1 Reply 1 reply @unimornnbr1 @unimornnbr1 1 year ago Its incredible that Mr Sinclair is 50 years but looks 30 Reply @870Slugger @870Slugger 1 year ago As soon as he starts selling athletic greens, I'm skeptical on his motivations to make this video. Reply @josepharico6463 @josepharico6463 1 year ago Can you be fasting 18 hours and still have athletic greens in the morning and not break the fast doing that Reply @littlegirl1225 @littlegirl1225 1 year ago Thanks for this episode. I wonder how you can carry a plant based diet that is consistent with keeping blood sugar stable. I’m wearing cgm and noticed my usual meals spike a lot, root vegetables and grains in particular. How do you reconcile these two recommendations? 6 Reply 2 replies @lauracastillo505 @lauracastillo505 7 months ago Is it true that gluconeogenesis in a regular basis causes insuline resistance? Thats excactly what the liver would have to do if we fast each day for at least 16 hours, is it? Reply @jakemaddox76 @jakemaddox76 1 year ago So a few things of note and couple questions: Dr. Sinclair mentions toward the end how we evolved (he mentions being cold and hungry, which is undoubtedly true for many of our ancestors). However, if you look at our very early ancestors like Australopithecus, they had a ribcage that flared at the bottom, like a gorilla. The reason for this flare outward is because like gorillas, they ate vegetarian diets that required more intestines to properly digest and extract the nutrients/protein. However, our more recent ancestors like homo erectus had evolved much more anatomically like modern humans, no longer with the flared ribcage. This is due to the fact we had switched to a heavier protein-based diet, protein that our brains needed as they began to grow larger. They also became very efficient runners. One theory is that these ancestors were endurance hunting, a type of hunting still practiced in parts of Africa by native peoples today. They would run down their prey, tiring them through endurance, sometimes for 20+ miles, as bipedalism is more energy-efficient than quadrupeds. There's no question that they were eating other locally available plants, berries, fruit and such, but it's evident that protein played a big role in our evolution. So I would ask the question whether or not a protein supplement could be taken that doesn't have BCAA's, as Dr. Sinclair mentions that these are the amino acids that stimulate mTOR. This might be more advantageous to athletes, or those who wish to train more intensely. BCAA's could be consumed infrequently, maybe twice a week for example. I'm also tossed on the intermittent fasting. I'm wondering if a big breakfast is better than a large dinner. I feel that any calories that are not immediately consumed within an hour or so before bed, will get converted to fat by the liver. However, Dr. Sinclair mentions that his glucose level is steady throughout the day, as his liver has been trained to do this. Does this mean that fat stores are being converted during the day from the previous dinner? Would this by definition indicate a state of ketosis? Additionally, would eating at night be better as it provides the body recovery it needs while we sleep (especially for athletics)? The other option is big breakfast or lunch, but after noting the aforementioned points, I'm not sure there are any benefits, other than possibly burning off the food throughout the day and not storing as much fat. Reply @mahriathompson6204 @mahriathompson6204 1 year ago David, Your partner is how we get understanding. You yourself talk too fast, monotone, and assume we know what you’re talking about. Your partner interprets and expands what you say. 1 Reply @margaritasmoliakova7084 @margaritasmoliakova7084 4 months ago Could somebody answer the question about fasting and the cause of forming gallstones. See that there IS the connection between intermittent fasting and formation of gallstones but can't find anybody mentioned this problem. Does intermittent fasting is dangerous and can cause gallstones? Reply @LenkaSaratoga @LenkaSaratoga 2 months ago EXCELLENT INFO 💚👍Could you please speak more about Janes in India 22:19 Reply @terry2346 @terry2346 1 year ago A lot of this sounds very familiar to those of us who follow the HFLC (KETO) diet. But getting enough protein and fat to be able to avoid( or keep very low) in Carbohydrates is very difficult with a vegetarian regimen! Some would say near impossible if you want to keep to 20 - 30 gms of Carbs to stay in ketosis, which is very beneficial for type 2 diabetics or pre diabetics. And is it the low carb diet that extends life or the protein avoidance? I do not think that has been clearly determined yet as far as I can see. 4 Reply 1 reply @DiscussYT @DiscussYT 11 months ago If you are on keto diet, you have no problem fasting. I am on the 5th day and I am good I am not convinced about vegetarian diet. After some age we stop producing carnitine for e.g. and it is found useful as a suplementation in Parkinsons and other condition. It tells me we need it. Besides, we evolved eating meat Reply @karinak09 @karinak09 11 months ago How much protein per day per pound? I tend to have a high protein diet 😅 Reply @pontevedra660 @pontevedra660 1 year ago I love you Sinclair!!! 1 Reply @markNL5 @markNL5 5 months ago About Mtor. I am at a high protein diet for high intensity sports. A combination of strenght and endurance, the allround aproach. The goal it competition level. So run a half marathon or lift heavy weights. So i need my fuel. At this point i eat a healthy and balanced with a focus on getting in enough protein. I Eat 3-4 times a day spread out over the day. After an intense workout (burning over 1000kcal) i really need to refuel. How would you combine this the longevity ambition? Reply @nature-zp7pc @nature-zp7pc 7 months ago does eating less often stimulate producing insulin? Reply @TheAustinDockery @TheAustinDockery 1 year ago I would love to see a lengthy conversation on exercise and what is best for longevity. Is it resistance training? Is it cardio? How much? 4 Reply 2 replies @p3shitonlin3 @p3shitonlin3 8 months ago So one takeaway is that we should eat more of stressed plant. But why this concept does not apply to animal (we know that animal was abused and face a lot of stress before they are fed to us) is this because of hormone-related issue? Reply @okidoki3201 @okidoki3201 1 year ago What about weight? What is an ideal weight for 1.8 m? And what about battling infection? Do you need more weight? Reply @markispink @markispink 5 months ago I like that they mentioned children in the end. Reply @angelicearthling @angelicearthling 1 year ago He lost me when he said he went vegetarian lol. Reply @thestreamoflife1124 @thestreamoflife1124 1 year ago My aunt was always over weight and lived into her 90s 1 Reply @sophistrydebunker @sophistrydebunker 1 year ago Perfect investment. Great dialogue. Question: for competitive athletes (I'm 62, train 10 hours a week, have a BMI under 20, a RHR of 48, and I do struggle a little with moderate systolic BP/in the 135-140 range) how do we eat? I'm burning tons of calories, and need energy to train, so where's the balance? What's a good reco? Do we just eat more and hydrate more than a person who doesn't? Curious 10 Reply 3 replies @Neilazbiker @Neilazbiker 11 months ago What do you do if your working hard all day? Like construction work? Or doing something like cycle touring? This is great if you work behind a computer in an office. Reply @KatheleenWaters @KatheleenWaters 5 months ago I feel sorry for laboratory animals, they are abused to the max, tortured, and should never have to endure this barbaric torture. 1 Reply @patconnell7055 @patconnell7055 1 year ago I would love to try fasting but I am very slim. Can I fast? Reply @markj850 @markj850 1 year ago dr BIKMAN and dr. SINCLAIR having a discussion would be a lifetime event. I don't think it will happen Reply @maryrobison1984 @maryrobison1984 1 year ago (edited) Members of the Baha'i Faith all over the world fast annually for 19 days from sunrise to sunset 😉 Reply @JuliaRawsome @JuliaRawsome 1 year ago Great talk I really enjoyed it. I‘m on a mainly raw vegan diet for years and I do the intermittent fasting. I can agree on almost everything what dr. Sinclair said. I have lots of energy, I feel and look younger and also I did overcome depression through this lifestyle. Let’s see what else can I expect in the future. Life just has gotten so much better 💚 9 Reply 13 replies @jlimarn @jlimarn 1 year ago David is 52 and looks amazing! Reply @shannajohannarosendal6160 @shannajohannarosendal6160 9 months ago Are these studies done on healthy people? I was sick when very young, and I nearly died from a vegan diet. I needed protein to heal? I changed my health through epigenetic meditation. Also regarding skinny elders. I have seen a lot of skinny elder die from simple virus illness, where the ones with 10-20 kg overweight could handle the longterm virus impact. Reply @michalc2972 @michalc2972 11 months ago so dr Sinclair skips breakfast, but he drinks Athletic Greens in the morning. Doesn't it break the fast? Reply @Joseph090969 @Joseph090969 1 year ago Wow you look great Dave haven’t seen you in a couple of years and you definitely look younger, you’d probably pass for 27 years old. 1 Reply @sanaamirza7 @sanaamirza7 1 year ago How we can reach the levels of iron, calcium etc that our body needs? Reply @lakshmiprakash4068 @lakshmiprakash4068 1 year ago Through Huberman I got introduced you Mr. Sinclair. Now its fascinating same feeling after going through you both podcasts. Thanks for all the information about health and longevity. 🙏 22 Reply @haifenghe @haifenghe 7 months ago 12:07 does high salt really activate the sirtuin gene? any evidence? Reply @yaelvitner7155 @yaelvitner7155 1 year ago I am in love. Thank you Reply @chrisburke9721 @chrisburke9721 1 year ago Can this show ever be done in 10-15 mins? 1 Reply @highcarbbeth5993 @highcarbbeth5993 1 year ago How do you get enough calories when you fast? I'm underweight. I would like to go back to Intermittent Fasting. Is it okay to eat lots of small meals in a six hour window? Reply 2 replies @snakeandturtleqigong @snakeandturtleqigong 6 months ago Thanks so much! Reply @Frogman214 @Frogman214 1 year ago Please cover when to workout during the Fasting window and when to feed following exercise. For your upcoming Sauna, Cold, exercise, show, please cover when is it best to exercise before cold, or heat or after? Any relationship with Heat Shock proteins, fasting, exercise, feeding and timing? Thank you! Great talk and questions! 4 Reply 2 replies @elizabethnilsson1815 @elizabethnilsson1815 7 months ago 57 .00 I can conform that what you saying is TRUE. I am NOT a alcohol drinker AT ALL. I went abroad and stayed in a Guesthouse where the owner had a winery. It was small about for to be on that regent which is know for BIG WINERIES, how ever we got all a bottle of wine as a welcome. I did not touch it at all as I am not a alcohol drinker, but they invited us for a visit in their wine cellar. In there wine cellar they showed us all the mold growing on the wall which looked disgusting.. but spending there 1 hour I tasted some wine and loved one of them which were in a tiny barrel very near to the most fungus on the wall. I got a small bottle free and i drink it though out a couple of days .... I COULD NOT BELIEVE WHEN PICTURE WERE TAKEN OF ME HOW INCREDIBLE THE COLLAGEN STARTED TO EXPAND IN MY BODY... and in the face and looked like 30 after a months there despite i was well over 60 years old than. I do not use ANY COSMETIC CREAM OR ANYTHING...! but after a months when I left the place and all the visits in the moldy wine cellars and get back to a place with black mold in a flat all disappeared totally.. The people who owns that cellars looks at least 20 years younger their age... and can work hard. SO I KNOW IT OF MY OWN EXPERIENCE that certain mold is EXTREMLY GOOD FOR THE HEALTH DESPITE THEY LOOK HORRIBLE.... and it was very smoothing even for the nerves and mood. That I can tell because I been invited many times for the wine tasting but I only tasted once - the first time and after that I did not drink at all just been with the other guest. Reply @reelinandrockin9022 @reelinandrockin9022 1 year ago I'm 65. I do weights at the gym every day. And I ride my bike 20 miles a day, five days a week. Should I be worried about going low protein???? Reply 1 reply @raistarithon @raistarithon 1 year ago so stop eating sugar. but what about sugar substitutes/artificial sweeteners? if you get rid of sugar from your diet, but consume artificial sweeteners instead, is it still beneficial? Reply @cryptomuscle3323 @cryptomuscle3323 9 months ago Mr Sinclair if flight and fight mode triggers the increase of growth hormone adrenaline and kills hunger and slows aging couldn't you trigger it using phentermine hydrochloride. Have you tried that. Reply @rajastoni4110 @rajastoni4110 10 months ago Has anyone tried working out almost every day and just eat once a day or would that not be recomended Reply @pedrochaves7496 @pedrochaves7496 1 year ago Thank you for the excellent episode! Brilliant! Still two questions (could you quickly mention them in a next episode?): 1-On fructose/fruits: how good are fruits in general? And which ones? What would be a healthy, anti-aging daily fruit consumption, if any (including dry fruits)? 2-You almost did not mention dairy products. What's their anti-aging status? For instantly goat or sheep cheese is kind of a regular, common food in most Mediterranean countries. Thank you again. 6 Reply 1 reply @fatimabroch6962 @fatimabroch6962 1 year ago What's wrong with the Mediterranian diet is that has breakfast - second breakfast - lunch - afternoon snack and dinner Reply @meathead365 @meathead365 2 weeks ago Its very confusing, David says he doesnt eat meat, yet others online say only eat meat. Personally ive tried keto, and now carnivore and i feel and look good, although i do have trouble staying asleep Reply @wylekyle2376 @wylekyle2376 1 year ago Longevity is what is Reply @jonparrott4081 @jonparrott4081 1 day ago (edited) I eat both sugars and proteins INTERMITTENTLY! Has anyone thought of that?! You'd think the meaning of "Intermittency" would be impressed on people after the incredible benefits gleaned from Intermittent Fasting.....Plant based mostly, some days okay to eat meat.... same with sugar: end of big meals, not by itself, and not too often ... INTERMITTENCY FOLKS!!! INTERMITTENCY!! Reply @productvisibilitytvshoppin1107 @productvisibilitytvshoppin1107 1 year ago (edited) Is there any evidence that these changes in diet can increase your testosterone levels and improve your sex life. If so, can you expound on those issues please? Reply @mdostay @mdostay 1 year ago (edited) Great episode! A couple of questions: 1. Any recommendations on types of fish (low toxic bioaccunulation, good fatty acid profile)? 2. Are lectins, phytates, and oxalates as bad as some claim? Steer clear of legumes, etc? 17 Reply 9 replies @aldroid4844 @aldroid4844 11 months ago I would be interested to know if you did any research on the Gene Therapy aka Vaccines 💉 during the little Covid bug and what you concluded? Did you get the Jab yourself ? Reply @garchkr @garchkr 1 year ago What about for children. This is hardly ever adressed. should they have at least 3 meals a day or should is fasting also beneficial for them? what are the impacts on their growth? Reply @komalthecoolk @komalthecoolk 1 year ago I've heard Valter Longo say again and again that any fast more than 12-14 hours can cause Kidney stones and other kidney problems. What does your research say about that? Reply @kurtpiatkowski4933 @kurtpiatkowski4933 1 year ago I am an orthopedic surgeon and my undergraduate studies were in nutrition which has also been my life long study. From a teleological aspect, humans are omnivors, if you look at our teeth, digestive tract, and digestive enzymes. We are not meant to consume dairy after being weened and definately not cows milk. I'm a bit confused with this shift to almost no animal based protein and a shift to plant based nutient sources. Shed some light please. Reply @kindalikeu.....5948 @kindalikeu.....5948 8 months ago Thank you!😉 Reply @arielherrera1996 @arielherrera1996 1 year ago Professor, are there any considerations to what should be eaten and when in terms of males vs. females (for example during menstruation)? I assume healthy individuals have the same longevity genes and protein complexes in context to longevity (AMPK, etc.), but is there research that points to differences in how these genes and proteins behave based on which type of reproductive organs people (or model organisms) have? 10 Reply 1 reply @penniroyal4398 @penniroyal4398 1 year ago I am hypoglycemic, I get dizzy, shaky and wavy lines in my vision when I’ve gone too long without eating. Can everyone fast or are their people who shouldn’t fast? 1 Reply 2 replies @katewright632 @katewright632 1 year ago Pesco vegetarian would be great. What about mercury and other toxin levels in the fish? Reply @w3w3w3 @w3w3w3 7 months ago Great Channel Reply @JohnDoe-hl2qm @JohnDoe-hl2qm 1 year ago "We will be all dead by the time human studies start to happen" Umm...not expected in this podcast Reply @bellaangelo8064 @bellaangelo8064 1 year ago (edited) Its so crazy i have a body builder lifestyle i eat alot of meat and proetien and bcaa and now im thinking to just 180 my lifesfyle to live longer, i even eat every 2-3 hours smh Reply @markpelayo @markpelayo 1 year ago You are Nobel Prize worthy sir David and Time Magazine Person of the Millenium. Thank you for your contribution to humanity. 5 Reply @Sharperthanu1 @Sharperthanu1 1 year ago I can tell that David Sinclair avoids the sun from the look of his pale wrinkle free complexion.Also not everyone is so slim when they are twenty years old or even when they are a kid. Reply @SherrickDuncan @SherrickDuncan 1 year ago (edited) Dr Sinclair what do you think of eating THREE MEALS PER WEEK i.e ONE MEAL PER EVERY THREE DAYS a week : (one meal Monday dinner time - one meal Wednesday dinner time - one meal Friday dinner time) Of a high raw vegan some cooked vegan whole food plant based high calorie and high unprocessed carbohydrate calories from fruits - vegetables - root vegetables - nuts - seeds - leafy greens - microgreens - cold pressed vegetable and leafy green juice - frozen fruit blended smoothies diet. With some organic grass fed and grass finished organ meats - meats - eggs - cheeses and raw milks etc every few months. What do you think about that? Would that help with longevity - slow and reverse aging effects etc etc? Reply @TuffCheez @TuffCheez 1 year ago For a 60 year old he's looking amazing! Reply @fenalraun9561 @fenalraun9561 4 months ago In a lot of the talks I've heard in recent years, there is advice to move away from "red meat." Unfortunately, no one ever specifies what this means. Just as there are chemical differences between farmed vegetables and "wild-simulated" (organic, threatened and stressed) vegetables, there are many chemical differences between a wild-lifestyle red meat source and a grain-fed, farmed red meat source. When a study states that it studied "red-meat" it fails to account for these chemical differences, instead couching a scientific proclamation against red meat behind the smoke screen of categorizing all red meat sources as identical. Until there are studies that show that wild-lifestyle red meat were the specific inputs producing the results, I have to assume that store-bought red meat was used, i.e. modern farming products, which means that it is not chemically similar to the red meat I may be consuming. If those studies exist, I would love to read them. Just as we are trying to change our body chemistry to be more healthy by eating different foods, so the plants and animals we eat can have their chemistry changed by their inputs. Why is this never a component of the research? Reply @ShashankTambade @ShashankTambade 7 months ago Can anyone please tell me what js the black coloured drink that these two are having in this episode? Is it just coffee or some other energy drink? I am curious. Reply @cosmos-smallpiece5786 @cosmos-smallpiece5786 1 year ago I really thought Matt guided this podcast extremely well and his questions and interjections were excellent . I recommended that everyone watches this . Great presentation 7 Reply 1 reply @jakobw135 @jakobw135 11 months ago How does the vegan diet compare to the Mediterranean one, for longevity? Reply @ericbaxter3944 @ericbaxter3944 3 months ago We still don't have any carnivore based diet research with red meats. They are omnivorous based diets with red meats in them. We still don't have any long term studies comparing whether carnivore diets are better or worse than vegan diets at this point in time. Otherwise I enjoyed listening to this informative conversation. Reply @MarikaAfrika @MarikaAfrika 10 months ago Thank you for sharing Reply @ChannelJtotheD @ChannelJtotheD 1 year ago Dr Sinclair this info is so conflicting. Iv listened to another Dr who is so sure that a conivore diet is the way to go for even long term. Plant based diets need a lot of consumption eg a piece of chicken in ratio to 6 cups of quinoa. Also as we age we need to have more skeletal muscle which is possible with eating beef 🥩 Reply @samuelherdyduarte101 @samuelherdyduarte101 1 year ago Justo nesse vídeo eu não consigo usar a tradução automática. Reply @marinafoglietti9351 @marinafoglietti9351 1 year ago (edited) I have begun to skip breakfast and dinner: one meal about three p.m. or later. That's fantastic. In the morning only 1 spoon of olive oil and vitamins C, D3, B and k2 mk7. Thank you dr. Sinclair. 4 Reply @artemstarkov7856 @artemstarkov7856 1 year ago Really enjoyed this with a bowl of cereal cereal at 2 AM Reply @DJdj-ir5uz @DJdj-ir5uz 1 year ago I heard you say you drink athletic greens in the morning. You also say you only eat one meal per day which I'd dinner. Doesn't the morning greens drink count? Reply @eleanastclare @eleanastclare 1 year ago Just because we are adaptive to our environment, doesn’t mean we are healthy. It comes down to quality Vs quantity. Don’t have a prob being a vegetarian, or meat eater, or any other way you choose, but for God s sake, eat for health, not for longevity, or because someone says doing it their way is the ‘right’ way. Do it for your health and what suits your mind and body and where you feel better. Note he mentions the ‘right’ social environment. This is a tell. Be careful who you listen to, who you model your life after. Model your life after what you want, what makes you healthy and feel good. What makes you ....you! Ask yourself that question. Reply @Babyy_girl @Babyy_girl 1 year ago What I wonder tho, it is commonly believed that the fact that millions of years ago we tamed fire and started to cook is the/one reason why our brain/intelligence is so much more advanced than of other species. If i understood it correctly, then it's the fact that cooking makes a lot of food more easily digestible in ways the brain benefits from it. First: is that true or is it a rather unsignificant factor in that developement Second: There is a theory that highly intelligent people or in general anyone who uses their brain a lot "uses/digests?" more sugar during the "thinking process". (Which for me would indicate that sugar boosts brain funktion at least momentarily) (If there's something to it) How does that correlate to the theory of "less/not as often is more" in terms of food and does that mean that being highly intelligent means you don't live as long? Reply @asaneryoga @asaneryoga 10 months ago Where can I buy NMN and NAD - no fake pages please ? Also I want to try on Cyclo-Sporine A, Minoxidil & Tacrolomis/Sirolimus. Reply @shelleyhuskey1870 @shelleyhuskey1870 1 year ago I’m an environmental professional and this is so exciting to hear, potentially positively impacting GHG/ global warming. 3 Reply @kateskeys @kateskeys 1 year ago My problem is- I’m not afraid of dying I don’t want to be 85. I’m afraid of living. Sometimes I think people try so hard to live forever. I don’t get that. No way in hell will I try athletes greens- the name alone is gag-worthy. Reply @hola-rk3lr @hola-rk3lr 9 months ago wait… I have plants that mature when they have everything on and plants that stay on their juvenile form when the circumstances are more rough. Am I right? 1 Reply @whatifi...2920 @whatifi...2920 1 year ago The way I analyzed Dr. Sinclair age is 45 years old ( I hope I'm wrong) pls comment below... Second I like it when he smiles or even just a half smile his adorable. .. anywo.... the only problem with this diet is I might be missing fats in my body that i need very badly ...(I have sciatic nerve problem) .. Reply @MrJoel9679 @MrJoel9679 1 month ago I know there is a lot of profundity in this session but I’m thinking straight up that bakers could make better bread for less sugar and yeast inputs! Reply @Rene-uz3eb @Rene-uz3eb 9 months ago (edited) 55:31 polyphenols chelate iron. That's why this works, not because of sirtium Reply @mukeshanand5124 @mukeshanand5124 1 year ago This is great, what you are doing is a boon to humanity 3 Reply @CheapHomeTech @CheapHomeTech 10 months ago So Athletic Greens proudly states it is nut and dairy free. Yet David Sinclair says he has a couple of table spoons of yogurt with it every morning. Furthermore he eats a handful of nuts throughout the day if he gets hungry. Is this an inconsistency? Reply @toddmazzitelli3159 @toddmazzitelli3159 1 year ago David, I think you need to really get to breaking down all meats and all vegetables. The reason I say this is not all meat is the same nor are all vegetables the same. I rarely eat pork. If I do, it is a slice of bacon because it happens to be available. I will eat chicken and or fish about once a month. I like vegetables but there are some vegetables I eat weekly and others that I will no longer touch. Also, interesting to me that you did not mention processed carbohydrates such as breads, cereals and pasta. Reply @morkie28 @morkie28 1 year ago May i know why the time restricted feeding is only less than 16 hours? why not 18 hours and so on? Reply @tolsen4893 @tolsen4893 8 months ago One thing regarding "what evidence from diets shows" : When "meat eaters" are surveyed in these studies are they really comparable and eating a balanced diet, or are they simply at the bottom of the "diet chain" - eating meat as burgers, ultra processed food, high sugar etc. etc. If you're a vegan or vegetarian, you are having a very carefully controlled diet straight out, and you certainly don't just eat anything off the shelf, you're taking a real interest in what you eat. A proper comparative study needs to make sure that the meat eaters involved are similarly "aware". I was for example stunned at how high in red meat the Argentinian diet is, and it has apparently been like that for a very long time. Yet I am not aware of any excessive mass prevalence of the diseases that keep getting cited as a result of over consumption of meat. Reply @salsipuedes8425 @salsipuedes8425 1 year ago How can i fast and eat less if i lifts weights and i dont want to lose my gains any advice? Reply @MARYROGERSG @MARYROGERSG 1 year ago Hi, very interesting podcast. I will like to know how does it works with people with autoinmune deceases. Thank you 3 Reply @catman4471 @catman4471 1 year ago (edited) Achieving immortality will take forever. Reply @amymcneal6180 @amymcneal6180 1 year ago Athletic greens break a fast. If he takes them in the morning, won’t that cause him to break his fast? Wouldn’t it be better to wait? Reply @laprechaun12 @laprechaun12 1 year ago What about fruit? He said something about fructose, but didn't go into detail about the fructose found in fruit. Reply @jimenakato9134 @jimenakato9134 1 year ago for sugar intake (glucose) does bread and other carbohydrates count as well? Reply 2 replies @adamhabibburatowski3276 @adamhabibburatowski3276 1 year ago Thanks alot for the pdcast and All this free knowledge I have question You say red Meat is bad for you. What about chicken and lamb? And you said you quit dairy products, why that? Is the keto diet bad? Reply @elliott1932 @elliott1932 1 year ago There seems to be a bit of a trade off between maximising muscle protein synthesis/muscle growth and longevity, how do we strike that balance - maybe a video on that would be great. Thanks 14 Reply 3 replies @bennoboy23 @bennoboy23 1 year ago yeah you might have to fight a lion to get it !! Love that ! it just shows we are not designed to eat meat . Milton Mills will tell you why Reply @Doctuber @Doctuber 1 year ago You shouldn't skip breakfast but skip dinner . Take two meal 10 am and 7 pm dinner . 15:9 diet. Buddha diet. Reply @antoniettabonfigliovetere1195 @antoniettabonfigliovetere1195 3 months ago Does anyone know if AG1 breaks your fast? Reply @suzannesutton5636 @suzannesutton5636 5 months ago (edited) When is Sinclair "drinking AG in the morning" if he is not eating until dinner?? WHICH natural sweetners?! Has anyone heard him speak on this elsewhere? (He showed off his Splenda coffee on Twitter) Reply @elena-251 @elena-251 1 year ago Thank you kindly 🙏 1 Reply @PushmoQRXO @PushmoQRXO 1 year ago This is a phenomenal listen. Great episode! 3 Reply @Botanifiles @Botanifiles 1 year ago What was the equivalent human gene called, for the PNC-1 yeast gene? Reply 1 reply @SuperBotanica @SuperBotanica 1 year ago people who now do the carnivore diet have become slim and healthy as a result. even a new Harvard study showed the extreme success Reply @jonathanthompson2704 @jonathanthompson2704 1 year ago Yes nut protein great and always drink water and tea and you won't be hungry. Reply @suzanneclemena4992 @suzanneclemena4992 10 months ago I’m off topic but…. I’m finding the wall behind you guys very interesting!! Reply @Funsoul8 @Funsoul8 8 months ago My vitamin doctor has me only eat cooked vegetables..no sugar and muscle tests me for standard process vitamins… Reply @williamowen2515 @williamowen2515 1 year ago (edited) I’ve read articles summarizing research that suggests increased NAD levels (from NMN supplements) may fuel tumor growth - specifically brain cancer. What say you, Dr. Sinclair? Also, in an interview with Lewis Howes, Dr. Longo expressed concern about the possibility of intermittent fasting negatively affecting the heart/circulatory system. He also referenced research indicating a link between breakfast and positive health outcomes - with the inverse being true for people who don’t eat breakfast. Do you and Dr Longo have conflicting points of view about this? I’d love to hear your perspective, Dr. Sinclair! 4 Reply @denmark672 @denmark672 7 months ago Skipping dinner is the most smartest thing you could possibly do because having a full belly with food while your in a sleeping position doesnt digest the food very efficiently and thru the whole night destroys your sleep and also your stomach you can negate this by elevating your bed to about 30degrees but thats pretty hard to sleep on 1 Reply @VORP125 @VORP125 1 year ago Wouldn't not eating for 3-4 days make your stommach digest itself and cause you a lot of problems? Seems like not a good medical idea to me. Reply @Imperial_Dynamics @Imperial_Dynamics 1 year ago Hi. What kind of nut is good? There are many. Also nuts and peanuts are different, right? When he said eat nuts if you are hungry (at 37:32) what nut exactly did he mean? Thanks. Reply @BobBob-uv9fq @BobBob-uv9fq 10 months ago just don’t think he looks incredibly young ,he looks like a reasonable 5- ish not crazy young Reply @titamama3378 @titamama3378 7 months ago Is Honey ok for sugar substitute? Reply @CrisMSG @CrisMSG 1 year ago Hi greetings from Chile, great episode. Always great to see the Vegan diet getting the recognition it deserves, is the best way to go, evidently, for us and the planet. 6 Reply @teacher12speaking63 @teacher12speaking63 10 months ago What causes Nail fungus? What food can I eat to stop NAIL Fungus. I saw a doctor and he says it is Psoriasis. He gave me tablets (METHOTREXATE ) for Psoriasis but it has side effects on liver. I used it for 6 weeks but I have stopped and kept my ugly nails. Reply 1 reply @donabelreyes6423 @donabelreyes6423 11 months ago I'm sorry I couldn't finish the entire video. But it's my understanding that plant based diet is encouraged. What about non-alcoholic sparkling red wine? Is that permissible? Reply @jessd.2684 @jessd.2684 11 months ago What if we don't want to lose weight? Reply @zul-qurnayn @zul-qurnayn 1 year ago ~@1:04 we should also blame the pharmaceutical and hospital industry who profits from chronic illness caused by sugar. I consider sugar a gateway drug. Heartbreaking how they also push formula in the hospital on new mothers, setting the trajectory of that babies health and immune system in the wrong direction. Reply @camiloandresleguizamon3624 @camiloandresleguizamon3624 1 year ago EXCELLENT Reply @kbakker @kbakker 1 year ago (edited) Love this episode and a lot of great insights. However in order to make this even better to consume Matthew should really just tee up the questions to David and provide him the space to speak freely. Some of the interuptions are incredibly frustrating. 4 Reply 2 replies @tolsen4893 @tolsen4893 8 months ago Good stresses...? Is the key the intermittent nature of the "stress"? As we "know" prolonged stress in people is certainly detrimental. So the important thing is to "test the boundaries" from time to time but not live in a state of continued stress of one form or another? Reply @petereriksson6760 @petereriksson6760 8 months ago Is it only the food industry? If the various pension systems are set to pay you from age 65 to death... wouldn't it be very profitable for the pension systems around the world if people do not stay alive? If the average life span goes up by just a few years, I am pretty sure the pension systems would crumble... Reply @mjdurham8 @mjdurham8 1 year ago any thoughts on progeria? Reply @roaminx @roaminx 1 year ago Complete Protein. What your body cannot create. I eat tons of vegetables and I'm always concerned that I may not be consuming complete protein. It seems to be shrugged off by vegetarian experts with the prevailing sensibility of, of course you are getting complete protein. I'm not convinced. It sure seems if one can get down to one meal a day it darn better well contain necessary nutrients and an appropriate amount of complete protein. Thank you. Looking forward to your five next sessions. I have purchased you book Lifespan. Reply 1 reply @freespiritwithnature4384 @freespiritwithnature4384 11 months ago Am I ok to take these without a gallbladder? Reply @joeanarumo616 @joeanarumo616 1 year ago We need more heroes like this. 5 Reply @jamesbyrne9312 @jamesbyrne9312 1 year ago (edited) David hates selling, you dont need to, you are already a huge authority. Just put links in the description, actually would build more trust than the selling. Reply @tonytee3372 @tonytee3372 9 months ago What about eggs? I love eggs! I could just eat only eggs for the rest of my life! Will my love for eggs shorten my life? Reply @sethnicholas6211 @sethnicholas6211 3 months ago Does David Sinclair actually drink Athletic Greens?? I am considering using this but I have some concern. Reply @georgannedermigny5992 @georgannedermigny5992 11 months ago how can you possibly "pack" enough nutrients in one meal per day?! Reply @kateskeys @kateskeys 1 year ago Can’t possibly coming over an hour to watch this Reply @Dani-jo9yr @Dani-jo9yr 1 year ago It’s called ‘bio hacking’ yourself- when you experiment on yourself. I do that all the time, my whole life.It’s so great as you talk then about stuff from very personal and true base, so it’s easer to help others. I am not ‘ a scientist’ per se but actually… I am a life long scientist 💯😉😁Great stuff, so love this topics 💜Thanks guys 🙏 3 Reply @fredbell4803 @fredbell4803 10 months ago Like so many people are now saying, never have a conversation or debate with a journalist. Journalists are the most uneducated and ignorant people in the world and most of them believe the world is as ignorant as they are. This journalist always interrupts dr Sinclair as soon as he starts saying something interesting, decides to reroute the conversation to its lowest possible level and dumb it down to the extreme. So many of my professors always told me to never bring a journalist to a conversation, they always make it about themselves and waste everybody’s time. I can see they were right. Reply @compassionsix @compassionsix 1 year ago Sugar is a broad brush. Does this mean refined sugars? What about fruits, berries specifically? Reply 1 reply @Ccowdog1 @Ccowdog1 1 year ago Can you do a show about getting over addiction like smoking Reply @undergrace1808 @undergrace1808 10 months ago Would like to see the day David go to the next level and be 100%plant based. Reply @Awakened.Vibration @Awakened.Vibration 9 months ago Protein blocks craving for carbs. I keep nuts in my car. Keeps me away from fast food restaurants Reply @apriljunehunt2548 @apriljunehunt2548 1 year ago (edited) I’ve been fasting since June 20 and I’ve never felt so good , I’m 60 years of age now I do Pilates and cycling which I’ve done for over 7 years , I do OMAD for 5 days a week and I have to say , It’s amazing. I do a full 3 day fast at least once every 2 months as I want more Autophogy . It works and I’ve never had a s much energy , I only eat my main meal at tea time between 5/6.30 that works for me, I only drink water coffee throughout the day and I eat a lot of nuts I don’t sugar I gave that up 20 years ago , I’m a healthy 9 stone 3 which I maintain. 12 Reply 5 replies @user-ln2ey6wh1e @user-ln2ey6wh1e 11 months ago I don’t see the study that he references about how red meat is harmful to longevity, where can I find it? Reply @Babyy_girl @Babyy_girl 1 year ago What about fasting/preserving and reproduction? Aren't those things completely opposing each other? How does having a child, espechially as a woman affect the mother's biological age and what should she keep in mind to preserve her own health yet be able to also have offspring? Reply @dr.tapasyadiwakar1246 @dr.tapasyadiwakar1246 1 year ago (edited) Dawn to sunset.. mentioned in ayurveda... Fasting is common in indian culture...ancient ppl know about yoga,meditation,fasting,magical herbs,ayurveda,spirituality.... They had so much knwledge without lab experiment. 🙏... But i feel bad coz these days we ppl are followoing western culture diet n style... And western ppl following us. Reply @irinat.6267 @irinat.6267 7 months ago This artsy guy in a hat definitely needs calorie restriction 😂 Energy in vs energy out - 1st law of thermodynamics. Restricting calories has been practiced by serious gym goers and bodybuilders for years, plus cycling calories Reply @suzanblackman7021 @suzanblackman7021 1 year ago How about Keto based diets? Reply @markoberarmath780 @markoberarmath780 1 year ago (edited) First of all, great podcast! Keep on 👍 However, I have a question. At 1:06:11 you've mentioned that 100k years ago men were hungry and cold. That's usually the argument for fasting (and all different kinds of diets), and longevity in general but I don't remember reading or hearing that those men lived 100years. Quite the contrary 🤷🏻‍♂️ 8 Reply 1 reply @erikobj @erikobj 1 year ago once he mentioned veganism he lost me lmao Reply @taramitchell3816 @taramitchell3816 6 months ago Please David do these sessions alone! Like dr Huberman. Love the way YOU speak. 1 Reply @williewaset @williewaset 1 year ago Which company is good for the NMN supplement? I can't find them with Thorne. Reply @Eva-xc8oq @Eva-xc8oq 10 months ago David. You are looking amazing and I continue to learn from you. Is your hair colour all natural. Reply @keyboardbunny @keyboardbunny 7 months ago Wish I can make my rabbit live longer. Only eats grass but has to eat none stop Reply @lixingpan4059 @lixingpan4059 1 year ago Great content and thank you! From my understanding, meat has much higher nutrition, and they are more bioavailable than plants in general. So logically I think eating meat and doing fasting to reduce the mTOR impact from meat might be a better option than vegan. Because I heard that you are likely to be somewhat in malnutrition if you don't do vegan correctly. What do you think? 9 Reply 3 replies @luciouspontorro3741 @luciouspontorro3741 8 months ago (edited) So disappointing they FAIL to mention how many calories (even a range) that we need to eat if we decide to try time restricted eating. Almost every academic podcast I watch fails to include specific guidance on how to properly incorporate what they're advocating. For instance, they say eat more vegetables....ok BUT how many?, how many different kinds?. If I'm switching to eating only 1 meal a day I really don't see how I will be able to consume 1900-2200 calories in one meal. Especially when a large portion of the is supposed to be low calorie vegetables and foods from the Mediterranean Diet. I also think they should have discussed how to incorporate this into an active lifestyle. For example should we have our 1 meal before or after strenuous cardio or weight training? So many unanswered questions :( I appreciate the podcast and Dr. Sinclair's efforts...I just wish he gave more precise guidance in key areas. Reply @pnk2748 @pnk2748 1 year ago I'm a born sceptesist but theres something about Sinclair that feels sincere and honest, i love sugar and meat but funny thing is that i feel alot better when i avoid them. Reply @maz.sniperonmicrodose6525 @maz.sniperonmicrodose6525 2 weeks ago Do i understand i right that its good to put your body in a kind of a stress (a bit hungry, cold). I have ptsd and am under stress a lot. It wears me out. And was thought meditation is the key. Or is this a different kind of stress that I experience. Reply @max_rove @max_rove 2 months ago David Sinclair is great. The other guy here interrupts too much though. He needs to listen more and let Dr. Sinclair speak uninterrupted. Reply @mysticcity312 @mysticcity312 1 year ago THANK YOU Reply @carolyn1111 @carolyn1111 1 year ago Thank you David!!! This information is coming out just in time @ 61 years old;). 🥳🎁🥦 3 Reply @mariamarghandewalsafi6368 @mariamarghandewalsafi6368 1 year ago Ramadan is the Islamic sacred month of fasting. There’s an effort here to completely ignore it. First they mention Islam and Ramadan last then he mentions the various benefits of fasting from dusk to dawn, that’s Ramadan. It’s unfortunate. There is so much to learn from Islam but the worlds war against it makes seemingly bright individuals close their eyes to a world of knowledge. Islam and science are interconnected. 1 Reply 1 reply @oe9276 @oe9276 9 months ago I thought Shiraz had most Resveratrol? shame I don't like Pinot Noir :-( Reply @MightyBooksOfHistory @MightyBooksOfHistory 1 year ago 44:14 Inhibition or activation of mTOR? I am a little confused here, high protein activates the mTOR, that's not good. That's what I understood as a true fact from this and previous episode. Here Dr. Sinclair agrees high proteins inhibit mTOR which contradicts his own statement. Please correct me if I'm wrong Reply @beardumaw24 @beardumaw24 1 year ago I disagree on some of his point. I was mostly organic vegetarian for many years and could not stay healthy or strong as soon as I added Meats and Dairy back into my diet along with the vegetables i immediately started gaining strength and got my health back. I am proof that a vegetarian diet does not work for everybody..Alot of it I believe depends on how your ancestors evolve. Reply @jeanalexandre1105 @jeanalexandre1105 1 year ago Antioxidants should help slow down aging Plus one meal a day. Reply @AwareParenting @AwareParenting 1 year ago (edited) Super interesting! I've been fasting 6-12 times a year for 6 years. I skip breakfast every day and aim to fast for 3-5 days each month. I usually want to keep going because I feel so amazing. The whites of my eyes glow and my thinking is crystal clear. Once I went for 9 days. As a woman, I have experimented with fasting in accordance with my cycle. I have found it best to fast during menstruation as opposed to during ovulation. I'd love to hear any research/experience done on this. 16 Reply 1 reply @marianavivanco4152 @marianavivanco4152 1 year ago I don’t know why my intuition tells me that we were hunters and programmed to eat meat, even if I am really empathic to animals and I would like to go vegan, but I feel in my gut is somehow wrong🤔 Reply @finspiration2666 @finspiration2666 1 year ago Mathew was a distraction for me mentioning opinions and quoting other's ideas. David had to work extra hard to stay on the important aspects of the subject and to finish his statements. I think interviewer Chef AJ would do these technical subjects justice by letting the expert talk, but I get its a podcast format and another ego is involved. Reply @osilva2367 @osilva2367 1 year ago I love this but it's disappointing that they don't mention the China Study. Reply @that_one_guy117x @that_one_guy117x 1 year ago The reduced meat thing is weird to me, and David looks really young but also doesn’t look very physically capable. Is that because reduced meat intake or lack of muscle building exercise? Reply 1 reply @victoriasun3729 @victoriasun3729 1 year ago Can you guys please talk about KETO? thank u! Reply @MartinMora @MartinMora 1 year ago I would love to have some more info around how to combine restricted feeding and high-intensity excercise. For example I climb several times a week and if I go excercise fasted, my forearms give up a lot earlier than they do when I do eat before. And that has become a problem for me to keep doing the fasting inthe right way. 3 Reply 1 reply @toddreilly8076 @toddreilly8076 1 year ago You might want to look at the high volume of very negative reviews for inside tracker since you tout it so highly. Was going to look into it and changed my mind once I read how badly the company is run. Reply @empirical77 @empirical77 10 months ago Elijah Muhammad espoused eating one meal a day and fasting three days out of every month in a book he wrote called “How to Eat to Live” over 60 years ago, mainly to poor urban Black people in America. Regardless of one’s opinion about him, no discussion about fasting and anti-aging in America should exclude his work. Reply @tumadre69727 @tumadre69727 1 year ago How the hell do I keep weight on fasting exercising and eating rabbit food? That's important talk about that. Reply @brettlagrange3944 @brettlagrange3944 1 year ago (edited) Love this convo….Am an athlete and stick with veggies, no read meat proteins, and good carbs….going to try intermittent fasting….only question is people who are eating meat are they healthy individuals….for example I eat low fat protein sources such as turkey and chicken Reply @ked4 @ked4 1 year ago Friendly reminder: Dr David Sinclair is 53 years old. Reply 1 reply @jamesoliver7398 @jamesoliver7398 1 year ago This is similar to the Huberman podcast. I love it and going to love this too. 9 David Sinclair Reply @shellybellyluv @shellybellyluv 9 months ago Great information but I think it would be really valuable to mention oxalates in this conversation. Yes vegetables and fruits are healthy for you but you need to be careful about choosing low oxalate ones. Just look into oxalate poisoning and you'll see what I mean. I thought I was being super healthy on my keto diet by eating spinach salads every day 😩 Then I would drink almond milk in my coffee every morning and treat myself with dark chocolate or peanut butter. Getting the toxins out after eating high oxalate foods is super difficult and not fun. Reply @MBEspinosa @MBEspinosa 7 months ago Aging worries us because the end is death. But it is part of the development. The individual is a part of the population. The population is part of the species. The species is part of the community, etc. The ecosystem is made up of many diverse communities and evolves together without showing clear aging patterns because it is more long-lived. But there are ecosystems that perished leaving descendants different from them. The big dinosaurs left small mammals and birds on the planet, right? But of course we are concerned about our individual "finiteness". DNA is one of the "responsible" but it is a whole set. Falling in love with yeast is understandable, I have fallen in love with germinating seeds because I have had to spend a long time with them, ha ha. I love your talk and I agree with the ideas and analysis. Let's see if we can get to age fully and what is the wisest thing for it! Reply @bogse @bogse 2 months ago 40:49 does anyone know ih he means here fructose added to food/drinks etc or fructose in actual fruits? Reply @carlaalfonsetti8355 @carlaalfonsetti8355 1 year ago Inside tracker is an American company how do Canadians get access to it or is their a Canadian company that does the same that we Canadians can access? Reply @pouranszekely-kiraly5076 @pouranszekely-kiraly5076 1 year ago what nuts to take if we must have to eat something? Reply @rockerteen8300 @rockerteen8300 1 year ago I’m wondering about things like, Choline, b12, D3, and omega 3 if you eat no meat. I mean I eat fish in small quantities for this reason, but if supplementation is to be used I think I would be concerned about the bioavailability of those supplements. 3 Reply 1 reply @j.villar6782 @j.villar6782 1 year ago What about the new science of Psico-Neuro -Inmune-endocrinology. Longevity. is not just about fasting and nutrients, not what you put on what you do not put into your mouth, it has to do also with Epigenetic the newest science that has not much to do. with your ADN, but with your environmental influences and Emotions, Spirituality, Family and personal relationship you state of mind, EMF exposure, heavy metal exposure, Hydrocarbons exposure and so on. Reply @balasubramanik4163 @balasubramanik4163 1 year ago In the name of God we don't eat much meat Most of us are pure Vegetarians Reply @JohnBell1958 @JohnBell1958 8 months ago Thanks David ++ Reply @hainesworld1 @hainesworld1 7 months ago The Adventist Health Group is a religious organisation, I think their science is probably flawed. Would like to see a more thorough analysis of that study you cite. Reply @TheRehan110592 @TheRehan110592 1 year ago meat and vegetable have different protein, both are good and we need both. Reply @IceStationZebraAssociates @IceStationZebraAssociates 1 year ago (edited) Meat and fasting are so compatible though. Going 18-20 hours is so much easier after a nutrient packed steak-and-eggs dinner + fat adaptation. 7 Reply 1 reply @austinknows456 @austinknows456 11 months ago If you have ears to hear check out Dr. Robert Morse and the raw vegan community perspective as well. Everything points towards plant based, lower protein diets being healthy. Modern scientific findings are showing this. Why not take it to another level and make it raw like how all animals in nature eat their food. The foods that can be eaten raw are fruits, veggies, and tubers, and some nuts i think. But be weary when you don’t feel good, detoxification is a must. Generations of eating certain foods that are inharmonious with the human have created changes and adaptations. An unnecessary need for stimulation of glands. The body wants to rebuild itself to become stronger and clear obstructions caused by acidic chemistry in the lymphatic system that derive from meat, dairy, starch. Human anatomy and psychology is close to that of a fruigvore/herbivore. Color vision, small mouths, small hands with no claws, specific ph levels of saliva and stomach, feelings of guilt to kill animals, closely related to chimpanzees and bonobos (frugivores). Reply @knightgod8082 @knightgod8082 9 months ago Omg David is so beautiful!!!!! Reply @jonathanthompson2704 @jonathanthompson2704 1 year ago note: ratio of omega3:omega6. Needs to be close to 1:1. Nuts are high in omega6. Reply @rexgraham2034 @rexgraham2034 1 year ago The researcher is such a great communicator. The interviewer's scattershot comments are so tiresome to listen to. He's trying way too hard to impress, rather than to facilitate meaningfully following the line of discussion. Reply @mohan2168 @mohan2168 1 year ago Wow, awesome video!!!! 😃😃😃😃 1 Reply @ltnats @ltnats 1 year ago David, thanks for sharing your great work with us all. I see you are saying we should avoid red meat for longevity. Have you seen a recent study on the Carnivore Diet from Harvard Medical School? Overall, the authors of the study found that “contrary to common expectations, adults consuming a carnivore diet experienced few adverse effects and instead reported health benefits and high satisfaction“. Detailed findings of the study are summarised below. I have personally seen this work in a mate that had Ankylosing Spondylitis where was in such pain that he couldn’t work for 3 years, took like 30 seconds to get out of a chair… he went to a swag of doctors and specialist and they gave him no relief. WIthin 2 weeks of doing Carnivore diet 100% no cheats he noticed significant reductions in pain. Within 6 weeks he got a job on a road gang building roads, hard work. It was amazing to watch, I was with him every week. Here are the findings of the study. 1. Self-reported changes in health status An overwhelming majority of the participants experienced positive outcomes. In particular: 69% improved chronic disease 95% improved overall health 91% improved hunger/food cravings 85% improved mental clarity 66% improved memory 83% improved focus 69% improved sleep 78% improved strength 76% improved endurance 89% improved energy. 2. Changes in chronic conditions and medication usage Again, an overwhelming majority of the participants reported improvements in chronic conditions and reduction in medication usage. In particular: 93% improved or resolved overweight/obesity (mean BMI decreased from 27.2 to 24.3) 93% improved or resolved hypertension 84% improved or resolved cardiovascular issues 98% improved or resolved diabetes and insulin resistance 97% improved or resolved gastrointestinal conditions 89% improved or resolved autoimmune conditions 96% improved or resolved musculoskeletal issues 96% improved or resolved psychiatric symptoms 92% improved or resolved urologic issues 92% improved or resolved dermatologic issues. 5 Reply 2 replies @electrotone2507 @electrotone2507 1 year ago The guy in the blue suit needs to learn to not interrupt Dr. Sinclair. I found it extremely difficult to follow the information flow, when Blue Guy constantly forced Dr. Sinclair to backtrack and change his subject and train of thought. 1 Reply @Hector-qu9vo @Hector-qu9vo 1 year ago I have three questions,. Can you please clear up the issue about soy raising oestrogen levels. Especially for women with endometriosis? Do you have any idea what causes endometriosis in the first place because no doctors seem to know what does cause it and there is very little research around this which is incredibly disappointing when 1 in 10 women suffer from this disease? Lastly , why do so many starving and malnourished women in Africa and other poor countries, still able to fall pregnant and able to carry to full term, when generally women who become severely underweight, no longer have periods and become infertile? Reply @moniequajohnson3094 @moniequajohnson3094 10 months ago With food price sky high we’ll live forever Reply @anonymousjones4016 @anonymousjones4016 1 month ago Jesus went into the desert for 40 days to test His human resolve. Master your hunger and you will yield a discipline that can then be leveraged for any passion you embark on. Reply @testg4andmmm129 @testg4andmmm129 6 months ago (edited) @00:23:16 you are describing ramadan 30day fasting. Its dawn to sunset And they do it every year. Reply @shotime3241 @shotime3241 1 year ago What qualifies as too much protein? Is it proportional to body weight? Is it proportional to the amount of other macronutrients you eat? You mention red meat in particular, does that mean white meats are fine? Asking because I want to build muscle but I also want to think about the long run! 6 Reply 1 reply @johnmartinsen7623 @johnmartinsen7623 9 months ago Why are you afraid to have a conversation with Dr Paul Saladino? He makes some good points that you clearly don't want to acknowledge. Upton Sinclair said it best..."It is difficult to get a man to understand something when his salary depends on his not understanding it." Reply @Resurrectingthegoddess @Resurrectingthegoddess 1 year ago I love what you do, I love what you share...but you seriously have to find a editor on 5'er or somewhere and have them cut your videos into shorts!! Just about every video online with you is over 1 hour!! which is awesome, but some people need to process the info in bit size chunks like 10 to 15 minute chunks! 5 mins even better... do you have any future plans to help the people digest info in smaller chunks of informative time? Thank you! Reply 2 replies @charlessavoie2367 @charlessavoie2367 2 weeks ago Does he ever mention selenium; jiaogulan; carnosine; taurine?? Reply @alremitances6872 @alremitances6872 1 year ago David I strongly believe research should be conducted on consenting adult humans leave all animals and plants to exist peacefully. All research on non consenting beings is considered cruel. Peace! Reply @DavidS992 @DavidS992 7 months ago Is anything like InsideTracker available in Europe? Reply @djamalsadaghiani2517 @djamalsadaghiani2517 1 year ago Waited the whole week for this episode! 21 Reply @focusedvegetable3655 @focusedvegetable3655 1 year ago It is a good podcast, but moderation should be highlighted. My issue is that he is 52 and he looks older and unhealthy. I have seen older people look way healthier. Reply 1 reply @laaneychoonz1330 @laaneychoonz1330 1 year ago 00:43:24 Carnivore diets are best? "When you look at populations, of what they eat and how long they live as well as the short term effects of high protein, carnivorous, red meat based diets... there's NO EVIDENCE, in fact I'd say there's COUNTER-EVIDENCE to that being beneficial for longevity". PLANT BASED FOR THE WIN! 1 Reply @rosagarcia7423 @rosagarcia7423 9 months ago (edited) I Eat very little red meat, mostly eat chicken because is cheap… what about collagen peptides protein? Soy protein? Good or bad? Reply @dvdgalutube @dvdgalutube 8 months ago I'm super confused by what this doctor said about fasting, and the host doesn't help by jumping around topics. When you are fasting, you aren't suppose to eat anything that has calories; therefore I'm confused by Dr. SinClair about eating nuts @ 38:00 . Once you consume nuts, you basically has broken your fast. I don't understand what is his definition of fasting. Reply @maratudorache8633 @maratudorache8633 1 year ago Do you recommend a teen to eat less and follow your tips? Reply @matthewperkins2950 @matthewperkins2950 1 year ago Do you know if it’s more important to eat the right foods or to avoid the bad foods? Even if there’s no specific studies on the matter, i’d love to hear your opinion. 4 Reply 3 replies @thenout @thenout 3 weeks ago Well, in regards to meat and mTor and all, most of it is quite contrary to what Peter Attia is finding and promoting on his own show. Given that you seem to be acquainted, why not address these conflicting studies - also in regards to the bioavailability. Reply @tanyalove6983 @tanyalove6983 8 months ago (edited) I just have one question for Dr. Sinclair. What about all those nations have have starving people? They do not seem to live any longer than others and they are fasting all the time. What gives.? I thought the less you ate and the more you fast the longer you will live. I guess you can even overdo a good thing like drinking too much water and drown. LOL. I noticed that Dr. Sinclair got down to a reasonable weight for his height not a scarecrow weight. This is just to notify all those anorexics out there you can go to far and harm yourself and reabsorb your heart muscle causing permanent damage and cause brittle bones by getting too thin. Key is to be reasonable. Dr. Sinclair I think you should check people of reasonable weight and see how long they live regardless of what they eat and you may be surprised and throw away all your theories. LOL. I guess not all of them some are very good and titillating. Reply @stephweissinger @stephweissinger 9 months ago Youre young. I'm 60 and have been doing Intermittent fasting for over a yr. I exercise 5 days a wk. I've lost 30 of the 50 I needed to lose. My skin will never be the same. I'll never have my body back.🙄 Reply @KJSvitko @KJSvitko 1 month ago Even children today have signs of artery disease. Fast foods and sugary drinks have long term consequences. There is an obesity epidemic today where over 60% of the population is overweight or obese. What is common today and "NORMAL" is not healthy. The average person today is not healthy and is taking medications. Heart attacks were once only common in people over 65. Today people in their 40 are having heart attacks. Add more plants and vegetables to your diet and less junk and overly processed foods Reply @MrAthorpedo @MrAthorpedo 1 year ago I'd enjoy this series a lot more if you weren't going against what you said in your book, Lifespan, about promoting companies, like your sponsors here. I'm sure you've justified it to yourselves enough to not feel a pang of guilt or contradiction, but you clearly state in your book that you do not sponsor specific companies. You can talk about the tools you use without mentioning brands, certainly. If your science and delivery is good enough, that should BE enough. I appreciate the research and work you've done to share your findings, but a viewer should no longer see you as unbiased or untouched by corporations. I guess that's the world we live in. - This comment brought to you by a diet-Pepsi influencer. Reply @eyeandmind @eyeandmind 1 year ago Thank you, David and Matt. 3 Reply @johndavidthacker @johndavidthacker 1 year ago It is not helpful to recommend a low protein diet and not define what that means. How many grams of protein per kilogram of body weight constitutes high or low protein consumption in your mind? Is 100 g a day a low protein diet or a high protein diet?Telling someone who may already be protein deficient to reduce protein intake is potentially harmful. Reply @sambee4927 @sambee4927 11 months ago Just eat healthy and fast occasionally and don't think too much about it. The fact is that we live in a world cursed by God because of what happened in the garden. You want perfect bodies? Believe in the Lord Jesus Christ and you will receive a glorified body that doesn't get corrupted when He returns. Reply 1 reply @jonathanthompson2704 @jonathanthompson2704 1 year ago yes sugar creates fatty liver. 16 teaspoons of sugar in a coke. Reply @SquatFull @SquatFull 2 months ago Dr. David Sinclair avoids commenting on the studies indicating that fasting does not impact longevity. Using oneself as a lab test animal and claiming benefits is not science. Reply @naturalsculpting1270 @naturalsculpting1270 1 year ago Amazing vid Reply @melissazimberg2456 @melissazimberg2456 1 year ago David, you relate the childhood obesity problem to children's' diets saying this is making them age faster. Do you also feel that this is contributing to the earlier onset of puberty? And at the other end, earlier onset of menopause? 3 Reply 1 reply @justinyoung8732 @justinyoung8732 7 months ago Check out the Ishaya's Ascension. It is a great spiritual practice to destress your nervous system and experience more peace and bliss. This is not a belief system like Christianity. Reply @mpumem.4143 @mpumem.4143 11 months ago Someone tell me he doesn't advocate against complex carbohydrates and promote ketogenic diet? I don't want to listen to something I'll never do. Reply @julycemonbleaux5263 @julycemonbleaux5263 1 year ago $1.99 Thanks! Reply @popedhop @popedhop 1 year ago I am a spiritual person. I believe fasting is healthy for the soul , not only biologically speaking. Reply @richwilson9517 @richwilson9517 1 year ago $5.00 Thanks! Reply @mailoisback @mailoisback 1 year ago Thank you so much Dr. David Sinclair and Matthew LaPlante!!! 3 Reply @KJSvitko @KJSvitko 1 year ago You are what you eat. Your diet impacts your health. Lower stress, reduce obesity and more exercise are key to a healthy life. Obesity in children and adults is rising across the world. Fast food and sugary drinks are contributing to the problem of poor health and obesity. Eat a healthy plant based diet and exercise regularly. Reduce or ELIMINATE cows milk, eggs, cheese and meat. Eat more salad greens, beans, fruit and vegetables. Eliminate fast food, snacks like cookies, cakes, chips, and sugary drinks and juices. Every adult and child should own a bicycle and ride it regularly. Regular exercise will help you sleep better. Yoga is a great stress reducer. Obesity is all too common today. Get off the couch. Get off the phone, ipad or video game. A variety of stretching and other exercises help with increased mobility. Ride to work, ride to school, ride for fun. Every city should be a bicycle city. Speak up for bicycles in your community Reply @user-hj2gz5sh6v @user-hj2gz5sh6v 10 months ago Great information. But I have to ask if you are in your 50s or early 60s. Or are you older? Because than I’d say its working. Reply @deanprecourt1280 @deanprecourt1280 1 year ago I fast 22 hours then eat an avocado, 1 hard b. egg, a little beef liver, sardines and steamed brocoli. Somtimes I swap out the liver for beef heart. Went from 200 lbs. at 5'5 inches to 140. 49 yrs old. 4 Reply @rimtasvilnietis2991 @rimtasvilnietis2991 8 months ago I am king of intermittent fasting Reply @heetsees @heetsees 1 year ago CA$2.00 Thanks! Reply @ClaudeDiamond @ClaudeDiamond 1 year ago What I like about Dr. Sinclair is that he looks like a man in his 20’s even though he is in his fifties. A person that practice what he preaches. So many health practitioners are overweight and look aged. 4 Reply 2 replies @davidx.1504 @davidx.1504 1 year ago (edited) David says you can quit something but still have little bites sometimes, even dessert. If sugar is the problem, couldn't you just find a sugarless version of the things you like? There are cakes, doughnuts, and ice creams with no sugar now 3 Reply @em-tee8408 @em-tee8408 1 year ago Getting younger now. I can feel it 🤞 8 Reply @thule7322 @thule7322 1 year ago Hello Dr. Sinclair can you please advise me if it's safe to take Metformin if you're not a diabetic and what is the dosage to be taken daily. Thank you for your podcast Dr. 3 Reply 7 replies @electronikadze.94 @electronikadze.94 1 year ago How can we follow a low-carb diet (as gluten and starch are proven to be some of the strongest triggers of inflammation and disease) while avoiding meat and still getting enough high-quality protein? 5 Reply 1 reply @wander4evr814 @wander4evr814 1 year ago (edited) When David was referencing athletic greens he said he drank it in the morning so so is he not considering that breakfast or breaking a fast 4 Reply @sumanagaraj2469 @sumanagaraj2469 1 year ago (edited) Long comment alert. Huberman brought me here. It feels like the low carb conversation has come full circle, and I am looking forward to the debates and conversations this will kickstart. Particularly Gary Taubes's reaction who seems to have become a tad more amenable to plant-based keto approaches lately >:) And I keep telling my keto nutritionist that you cannot take plants out of a vegetarian's diet for even a day. Those who have known, um, regularity, all their lives just cannot be convinced that meat and butter are great for their joints when their digestive systems are cranky. That the plant-heavy diet is a colonic the way God intended. Jokes apart, the vegetarian in me feels vindicated. I think India still has a long way to go in all its micro and macro communities to address heavy consumption of grains and the resultant hyperinsulinemia that plagues us as a nation. The low carb conversation has just begun here, and I feel the reason the Mediterranean diet is referenced as much as it is in the health/longevity conversation is it is the only approach that doesn't bank on sweet as the primary flavour like the SAD/Western diet does. Tried it all, but Indian spices and flavour profiles for the win for me. So plant-based for longevity, carnivore/meat-based/animal protein-based for better body composition and better fitness and better performance, keto as a tool to reverse complications from metabolic syndrome and as a periodic reset, fasting as a long-term lifestyle for the benefits of ketosis and autophagy and better management of blood markers. So LCHF IF it is for the win. 10 years on an LCHF IF lifestyle, with longs stretches of alternate day OMAD, and I am a walking testament to what it can do to reverse complications from bad nutrition and lifestyle choices and the tyranny of genes. ETA: refused statins nine years ago :) Cheers to you! With a glass of pinot noir. Subbed. I remain utterly fascinated by the science of human biology and the ways in which we can take control of our bodies at any age. Thank you. 5 Reply 2 replies @friktermind @friktermind 1 year ago Dr. Sinclair, please divide the knowledge to male and female. We know that women's biology is far more sensitive to (for example) fasting. Please, please, please, this is crucial. 7 Reply @Cel12495 @Cel12495 1 year ago Glad he mentioned longo fmd. But Longo says it’s best not to time restrict feeding beyond 12 hours….says 16 hours can have negative effects 6 Reply @PatrickNoonan @PatrickNoonan 1 year ago Do you take your Athletic Greens in the morning when fasted or when having your dinner? One serving of AG has around 50 calories so might be too much if you want to stay fasted. 8 Reply 3 replies @deirdreloraine5653 @deirdreloraine5653 1 year ago Here r 3 SIMPLE rules to forever weight loss and maintaining ur perfect weight …. Diets DONT work 1 Eat when u get hungry not when ur bored or cause ur emotionally eating , stop eating long enough to get hungry 2. Eat only until ur satisfied, not stuffed , not full , just comfortable 3. Eat the foods u crave and love . Perfect weight No suffering Listen to ur body 8 Reply 1 reply @ComedyByAlan @ComedyByAlan 1 year ago Absolutely incredible knowledge here. I started with a 14 hour daily fast and worked my way up to one meal a day after about 18 months but my diet consists of a lot of red meat (organic grass fed ribeyes 3-4 times a week) since my body craves it. Time to look into the Mediterranean diet and work towards that to see how I feel with it. I also apparently make the big mistake of starting with something sweet if that’s what I’m in the mood for. This vid should be standard watching for teens 7 Reply @vdantas @vdantas 1 year ago Great podcast but the mTOR messaging seems to be a bit off. David Sinclair is ignoring the fact that carbohydrates also activate mTOR. And given that carbohydrates activate insulin to a greater extent than proteins do, it also inhibits AMPK to a greater extent. Even if free of sugars, a diet that limits protein will invariably increase carbohydrates significantly, so I don't see how David Sinclair's logic holds upm All studies listed that point to links between vegetarian diets and lower all cause mortality were weak epidemiological studies subject to healthy user bias. Fasting and eat less often is starting to sound like solid advice given the weight of research behind it, a lot of which was contribution from David Sinclair himself, however, there's no sufficient evidence to recommend people eat a vegetarian diet to improve their longevity. In fact, there's some good evidence of the contrary, given how nasty things like oxalates and lectins (very common in plant foods) are proving to be. 6 Reply @marcela1082 @marcela1082 1 year ago I eat when I’m hungry I’ look pretty fit 3 Reply @AngelPerez-un8ne @AngelPerez-un8ne 1 year ago Doctor yo soy un humilde psicólogo venezolano y apenas y doy clases en una universidad que no vale la pena mencionar, me encanta su potcast pero por favor salga en camisa siempre, el efecto halo es de un alcance increíble. Mis amigos y yo notamos incluso la diferencia de solo escucharlo o verlo. 3 Reply @sairamgajula6377 @sairamgajula6377 1 year ago Our indian yogic scriptures have told this about 3000 years ago. 4 Reply @vladyslav743 @vladyslav743 1 year ago (edited) Recent study about Metformin on humans from 2021 showed no benefits in all cause of mortality. So it's definitely overrated. "Effect of Metformin and Lifestyle Interventions on Mortality in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study" 3 Reply @spengali857 @spengali857 1 year ago (edited) Been looking forward to this channel. One thing I would suggest, out of the gate, is have the flashy "cohost" pipe down. We want this channel for David and his knowledge! Lastly, you’re too smart David, to think vegan is good for long term health. It definitely is not! 5 Reply 1 reply @teresa22885 @teresa22885 1 year ago Can we please please please ask Matt to stop interrupting you! Every time you’re on a roll he chimes in with a question or comment. He’s good to have but just interrupts too much! Thank you for creating this show, I love it! 170 Reply 20 replies @georgekolo3817 @georgekolo3817 1 year ago I like this podcast, but I don't see why matt is on it? No disrespect to him but I feel like a lot of the points he adds hold no value. 4 Reply 1 reply @c0rvidae @c0rvidae 1 year ago It's my understanding that it's actually excess dietary fat that causes insulin resistance and not sugars from starches like potatoes or (white) rice. The information shared here on that topic I feel should be taken with a grain of salt, as medical practitioners in the plantbased community have been reversing type 2 diabetes in patients for decades with this model. I feel David knows his stuff about longevity, and of course excess processed crap and refined sugar is bad, but I think villainizing freakin' potatoes is inaccurate and while I'm no nutritionist, neither is he. Great podcast though and very interesting! 3 Reply 5 replies @ntrelis @ntrelis 1 year ago Fasting and prayers work miracles! Read your Bible and trust Jesus ! 3 Reply @funenglish8128 @funenglish8128 1 year ago You have so many vitamins sponsors, which kinda makes me questioning information you provided 4 Reply 2 replies @DFF1234 @DFF1234 6 months ago $2.00 Thanks! Reply @albdeslam6586 @albdeslam6586 1 year ago our prophet said the best diet is that of the Prophet David he ate one day and fasted the other, technically one meal a day. Reply @anieluthien7671 @anieluthien7671 11 months ago In this plant base diet recommended, is fruit included? At some point Dr. Sinclair said something like eating a slice of orange... god forbids.... Reply @zinahsdiary4433 @zinahsdiary4433 9 months ago I hope AG is available in SG Reply @reesedundee8525 @reesedundee8525 1 year ago so what im picking up from this makes sence, the less you put in to your organs the less they need tyo work... makes sence tbh. Then it goes back to a very old saying, "everything in moderation". 1 Reply @dennisams6954 @dennisams6954 1 year ago But I want to gain weight and muscles... But intermittent fasting causes weight loss.. So all bodybuilders are unhealthy because they eat a lot the whole day? 1 Reply @zhaodeli577 @zhaodeli577 3 months ago GOOOOOOOD!👍 Reply @Marevrick @Marevrick 11 months ago how do I do this If i want to do bodybuilding aswell????? Reply @potentnaturals188 @potentnaturals188 1 year ago I wish Dr Sinclair can talk more and not interrupted with questions that cut short sometimes his answers. Reply @koltoncrane3099 @koltoncrane3099 8 months ago Everyone talks about a plant based diet, but what about mushrooms and Chinese and Vedic traditional medicine. 1 Reply @pepa1420 @pepa1420 6 months ago ATLETIC GREENS, IS IT SOLD IN AUSTRALIA??? Reply @dodo0132 @dodo0132 10 months ago If the fasting help, but why has Dubi people life average expectancy 78 years and Japanese can have 82 years? Reply @tobiaskevorkazito4072 @tobiaskevorkazito4072 6 months ago Matt! I luv that shirt so much I found one on eBay 🏴‍☠️❤️😂🥊 Reply @edenbound1574 @edenbound1574 7 months ago I need evidence without sponsored ads. Reply @666gmurder @666gmurder 9 months ago Brilliant Reply @kunaplayssp7561 @kunaplayssp7561 8 months ago You can't stop your nose and ears from growing, that gives away people's age. Reply @katherandefy @katherandefy 1 year ago You have yourown channel?! Subbed!! Reply @Destinys-CHRIST @Destinys-CHRIST 1 year ago What about whether or not consume egg yolk! Reply @Zar4thustr4 @Zar4thustr4 10 months ago 37:31 Nuts have about 4 times more fat than proteine Reply @muhubobulhan6318 @muhubobulhan6318 1 year ago That’s why Religion people have to fast. Fasting existed since human have existed but we never follow God’s command. It’s not new to me fasting and now I have to complete one month fasting without water and still I feel good. Reply @ixur1960 @ixur1960 10 months ago Exposing them to so much sugar so early in life … Reply @Lugg187 @Lugg187 1 year ago We should avoid high protein red meat diet for longevity. It inhibits mtor. But from meat we get the amino acids. Important amino acids: Leucine, isoleucine, and valine: BCAAs. Are used to sense protein intake. The sensor is mtor. The mtor activates when you get them. Mtor repairs and build muscle. In the short run, this is good for building muscle etc. But in the long run, mtor is the responsible for autophagy, which is key to longevity. So if mtor is good for autophagy and autophagy is good for longevity, and if mtor is activated by amino acids, and if we get amino acids from meats, WHY is meat intake bad again? Reply @webapple1 @webapple1 7 months ago how do you get to that , i get hungry if i dont eat like 4-5 times Reply @ghosthail @ghosthail 1 year ago You should get a new co host Reply @dr.t.m591 @dr.t.m591 8 months ago What is the difference between B3 NMN Reply @user-hh8nd3ml4s @user-hh8nd3ml4s 10 months ago I need help please i can do omad everyday all live ( i learned how to beat hunger already ) it's not hard at all for me but i need to know when approximately is recommended to break this regime ( to reset this type of live ) . Reply @fiftiesandfabulous @fiftiesandfabulous 1 year ago It cost me $117 Australian dollars. How is that affordable with the current situation we live in. Seriously Reply @tracylynngibson7330 @tracylynngibson7330 1 year ago David I know I'm chiming in early in you pod casts, I saw a infomercial about Resverotrol superficially as an ingredients in a skin care product called Cellabeauty Reply @mariejones7136 @mariejones7136 9 months ago Why do I get dizzy and blood sugar drops if I don't eat ..If I stay home I'm fine but if I go out I get faint...I try and fast everyday .. intermittent fasting and I did 2 days and four days but I did have bone broth because I was starving... Reply 1 reply @guidosillaste4297 @guidosillaste4297 3 months ago Yeah but you need to have feast before fast in order to build fat just like bears. Reply @saintesubs @saintesubs 5 days ago What if you want to gain weight? Reply @avneetsinghkhorana5265 @avneetsinghkhorana5265 8 months ago He does not look like a 53 year old at all or maybe those who look like it are doing something wrong? Reply @SonnyDarvishzadeh @SonnyDarvishzadeh 1 year ago 59:20 which studyy shows meat and processed meat are cancerous or increase the ageing? I can't find the link in the description Reply @sonntagshans @sonntagshans 1 year ago What is the name of this well-studied religion from India that deals with fasting? Reply @goldenbelly8268 @goldenbelly8268 1 year ago 10 stars, never mind 5 - maybe 1m stars!🙏🐬🌈 thank you/1 Reply @lindaninocampos5727 @lindaninocampos5727 1 year ago Muy similar a canal Metabolismo TV y su programa natural slim . con Frank Suárez Reply @magdanieniewska2687 @magdanieniewska2687 1 year ago (edited) Dr. Sinclair, you keep mentioning in your interviews that you're trying to avoid carbs in your diet. Are you only referring to processed foods (like pasta, dough, etc.) that cause extreme blood sugar spikes? Since, according to the latest science regarding the optimal diet for health and longevity, scientists and doctors stress the importance of eating wholefoods (potatoes with skin etc., i.e. fruits and veggies that contain the original amount of fiber) to keep the blood sugar levels stable. Especially the starchy veggies are considered to be very satiating when eaten in their original, unprocessed form. What's your opinion on this? Reply @fd4553 @fd4553 1 month ago Are they saying that natural sugars like in fruit are bad too? Reply @accaliawolverton7830 @accaliawolverton7830 1 year ago I have IBS and most veggies and some fruits cause flare ups for me. How am i supposed to work around that?????? I dont eat red meat because im allergic on top of having a ton of other allergies. No legumes, or nuts, which btw cause inflammation... why dont you talk about inflammation, stress and sleep as helping with aging and health???? Reply @elchappo1320 @elchappo1320 1 year ago Can someone give me the summary Reply @beaware354 @beaware354 8 months ago 22:37 Ramadan yes but then they binge eat in evening and let me tell you it’s not on broccoli they binge on but on a lot of fried foods and pastries, I don’t think it supports health Reply @linyan9299 @linyan9299 1 year ago Asian countries live on glucose to live, but in Hongkong and Japan boasts of longevity of human life, obviously only what you eat and when you eat can not explain why people more healthy than another. Reply @divyarth97 @divyarth97 5 months ago Love both of you, thanks! but the guy in the hat needs to stop interrupting and diverting the conversation and let David talk 1 Reply @m3coo @m3coo 9 months ago Never start a meal with sugars! what about pasta? avoid? Reply @KotobukiGirl @KotobukiGirl 1 year ago 17:44 "...presumably the people watching this are human beings." Lol. Reply @waterneversleeps @waterneversleeps 8 months ago Is this okay for women trying to get pregnant?? Reply @curtiscanady7962 @curtiscanady7962 8 months ago I though they just came out with a study saying nad boosters can lead to brain cancer or accelerate it? Reply @AishwaryaPratimRabha @AishwaryaPratimRabha 1 year ago thank you Reply @64Street @64Street 1 year ago My favorite is a bowl of steam at 3:00AM. You just can't top this. Try it. Reply @davidcorona2424 @davidcorona2424 1 month ago I have 70kg... if i eat less... i will dissappear... Reply @ratnaali8206 @ratnaali8206 2 months ago Man with hat keep point his finger . David so calm Reply @bataalexander9703 @bataalexander9703 1 year ago 16:26 How proteins can be old, what does it mean? Reply @joZieDiMaria @joZieDiMaria 1 year ago Eating once a day is not possible for body builders Reply @flipstor @flipstor 7 months ago Does anyone have an inside tracker alternative for europe??? 1 Reply @thestreamoflife1124 @thestreamoflife1124 1 year ago Eat less often .... intermittent fasting is perfect 1 Reply @makaylahollywood3677 @makaylahollywood3677 8 months ago When you begin a fast, take it slow.;) Reply @XX-fq8kp @XX-fq8kp 11 months ago (edited) NOT EOUGH ON THE ADDICTION OF FOOD…. Or DID I MISS IT Reply @tracylynngibson7330 @tracylynngibson7330 1 year ago sorry, I was not done, I it real can a superficial application of resveratrol work to help the skin with anti aging? Reply @lizakroberts @lizakroberts 8 months ago This Is great info, but what do I feed picky, picky children who need a lot of iron and protein to grow and who are bombarded with offers of junk food daily? (They serve junk at school!) 1 Reply @aksamitnaPiesc @aksamitnaPiesc 1 year ago Hello! Hello! We are from Poland! :) Great to see you. :) Reply @iamrips2132 @iamrips2132 1 year ago Can someone please give me a gist / takeaways of this VDO. I don't have the patience to listen to 1 hour VDO. Please🙏🙏🙏 Reply 1 reply @maurameadesperry1715 @maurameadesperry1715 9 months ago (edited) Athletic greens does not affect a fast?!.anyone know? Reply @JOHNWAYNE1920 @JOHNWAYNE1920 7 months ago Says "you wouldn't drive a car without a dashboard" then says "this is why i have autopilot", the name of the self driving software in tesla, cars that don't have dashboards. Reply @robingaytala @robingaytala 1 year ago Voltor Longo who you mention Mr. Sinclair works for USC. longevity Institute, not UCLA. Reply @helenostap6245 @helenostap6245 1 year ago Levels not available in Canada. Reply @meloniemartin6300 @meloniemartin6300 4 months ago Dr Sinclair. What do u feel about Carnivore but Omad. So when I re feed once a day. It's meat Reply @markf2598 @markf2598 1 year ago Could you please talk about milk, is animal milk healthy or deadly? Reply 1 reply @rocsocom3166 @rocsocom3166 1 year ago I wish they make short videos and to the point i can't watch 1 hrs. Reply @gailaila1143 @gailaila1143 1 year ago How can you say you drink athletic greens in the morning when you are fasting all day? Reply 1 reply @ashekinmostafa @ashekinmostafa 11 months ago ❤️❤️ Reply @pinaypinay8384 @pinaypinay8384 1 year ago somebody pls answer me i am taking virgin olive oil 1 spoon before and after bed . is it good or bad. Reply 1 reply @siddeeee @siddeeee 1 year ago He's even trying to reverse age his clothing. Lol... Reply @TheMotorTrade @TheMotorTrade 7 months ago 100,000 years ago people were cold and hungry.....and they died by age 30, usually of their teeth infections. Don't think we need to go back there Herr Doktor. Reply @pubwvj @pubwvj 1 year ago Irony: Dominos was the ad from YouTube ate the start of watching this video… 🙃 Reply @wcneathery3100 @wcneathery3100 1 year ago Adventist Study, really! No bias there. Reply @oman9492 @oman9492 1 year ago Like governments and big pharmaceutical companies are going promote this stuff. In fact they are already discrediting many of these ideas. Reply @g.m.5361 @g.m.5361 8 months ago NMN ! Looks like No Other Research (other than Dr Sinclair's) has been done to confirm his conclusions about NMN. 1 Reply @jonathanthompson2704 @jonathanthompson2704 1 year ago This guy should learn more from Dr. Gregor. Fish better than beef. Reply @ss2824 @ss2824 1 year ago Cant believe this guy is 63 😮 Reply @janetmanooki5967 @janetmanooki5967 1 year ago Great Reply @hugo-ge9tw @hugo-ge9tw 1 year ago What about all the recent studies coming up about red meat being actually best? Reply 1 reply @Martin-bk3sp @Martin-bk3sp 9 months ago 40:50......" fructose is also pernicious"......so we don´t have to eat fruits? Reply @petemiller5705 @petemiller5705 11 months ago much better Dr. Berg’s Meals and Intermittent Fasting Pattern without Commercial BS Reply @gwynerskine6853 @gwynerskine6853 7 months ago Guess what Dr. I believe that 1 stay away from prescription drugs 2 when it's time to go you will?? Reply @beatrizrosado898 @beatrizrosado898 1 year ago What about people with BDS? GASTROS TELL TO EAT 6 TIMES SMALL PORTIONS? Reply @TheLadyJain @TheLadyJain 1 year ago At 22:33 min into the talk, I see that your subtext is spelling the "Jains" in India as "genes"...hope you can fix? Wonderful info, otherwise!! Reply @tonyborg4510 @tonyborg4510 7 months ago Video is good but too long. Reply @janawall3306 @janawall3306 10 months ago I am struggling to understand. I need to know what to do. Reply @wideglidewhipper @wideglidewhipper 1 year ago i don't know anybody who eats 1 meal a day. Does he only ''think''. IF he actually did physical labor i doubt if he could exist on one meal a day. Reply @Mokolibi1 @Mokolibi1 1 year ago How can someone who does gym work around this? They eat several times a day Reply @valentinadehtiyar9548 @valentinadehtiyar9548 7 months ago I believe he also takes metformin. Reply @Fanaro @Fanaro 5 months ago 1:03:07 Don't forget "become a skinny tiny woman" Reply @aliciastanley5582 @aliciastanley5582 1 year ago I have a $35 ice cream maker and make my own Keto ice cream with coconut milk & cream with stevia and vanilla & other healthy flavorings. Make my own ketodeserts. The internet has all of these. Just Google what you want. I allow myself 1 keto dessert a day. Moderate to small sometimes more. Reply @perrya4878 @perrya4878 1 year ago That guy never blinks Reply @johndoe9362 @johndoe9362 11 months ago LaPlante was cutting off Dr. Sinclair. Please let Dr. Sinclair speak. Reply @briangular2115 @briangular2115 4 months ago you should have a chat with gary fettke Reply @NickAnanas @NickAnanas 1 year ago There must be some mushrooms for longevity! Reply @kimberlysollenberger1552 @kimberlysollenberger1552 1 year ago Say what the public needs to hear. Don't get all were not fat shaming anyone. This is information. You need to say, hey this is important. Your not going on Instagram insulting peaple or Twitter. Peaple come here for truth and information. Since when are Doctors so afraid to talk about health. Woke much?? Reply @okazaki111 @okazaki111 1 year ago What to eat Of course it's important, but just as much, how much do you eat at one time? I feel that the viewpoint of is lacking. The volume of food served in Western restaurants is twice that of Asia. Do Westerners know the risk of becoming obese by eating too much? I would like you to compare the rate of pot-belly in Asia with that in Europe and the United States. Reply @marper00 @marper00 1 year ago but, animals we are....so good! Reply @phyllisriley1013 @phyllisriley1013 1 year ago Allergic to tree nuts. Do not eat meat. Beans cause gut issues. How do I get enough protein? Reply 1 reply @amalb4331 @amalb4331 1 year ago What about coffee? 1 Reply @rohanrane5762 @rohanrane5762 4 months ago I would like to suggest one thing to david sinclair very very seriously: > please study the ancient indian sciences of "yoga" and "ayurveda" seriously without any preconceived notions, these things are concerned with health (both physical and mental) and longevity in humans on very advanced levels. > I will recommend you a book called 'A SEARCH IN SECRET INDIA' written by paul brunton, you will get an insight on what is the potential of real 'yoga', and for anyone reading this comment bear in mind that the yoga which we see on these social media platforms is just a very very small part relating to body postures, the real practice of yoga is extremely difficult and involves numerous elements which can be taught only by the real practioners who are hidden in india. > people in india themselves are ignorant about these things but only people with an open mind like you will be able to realise the true potential of these things, without naming it as 'pseudoscience'. > I highly suggest you to read books written by PAUL BRUNTON it will be immensely helpful in your research for human longevity. Reply @geraldmarcus7233 @geraldmarcus7233 10 months ago Are they bad for longevity? ' Reply @jamesortega8681 @jamesortega8681 10 months ago so body building is out the window and say hello to frailty lol Reply @rachelann3662 @rachelann3662 1 year ago I heard this guy say he drinks diet cokes all the time. Don’t take nutritional advice from him Reply @pauljewell7097 @pauljewell7097 8 months ago Lose the guy with the he detracts from the whole interesting subject matter your the one with the information he just breaks up the concentration of the viewers PS I've been doing this all my life with out knowing I'm 70 in perfect health still working fixing peoples roof's 3 story ladder work my doctor thinks I was abducted by aliens and like my father and grand father I zero grey hair 1 Reply @heavenonearth1604 @heavenonearth1604 5 months ago JOHANNA QUAAS I THINK SHEIS A VEGETARIAN SHE IS 97 WHAT SHE DOES ON PARALLEL BARS IS AMAZING Reply @castellanofan1365 @castellanofan1365 5 months ago Autophagy 🔥 Reply @rob3533 @rob3533 10 months ago Unless you're about to die at 50, why would i want to extend my life? Lets say i'll live to 75-80, what joy is another 10 years in a care home? Reply 1 reply @Cherryontop10 @Cherryontop10 7 months ago The interviewer needs to stop cutting off the professor to explain what’s already explained. The interview feels choppy which leads to a lot of “we’ll get to it later”. Thanks. Reply @DelusionDispeller @DelusionDispeller 8 months ago Ok but the mastering Diabetes ppl say to eat lots of fruit Reply 1 reply @angierotter2357 @angierotter2357 1 year ago so metformin is good but what about berberine? Reply 1 reply @soslime-gj1rx @soslime-gj1rx 1 year ago I only eat breakfast :) 1 Reply @therustingmind1895 @therustingmind1895 1 year ago Over 1 million views and only 38k likes. Come on people like the video it cost you nothing and really helps get this information out. Reply @vadim3 @vadim3 8 months ago Cut the meet or cut the red meet? Chicken is ok? Reply @kaptainh5538 @kaptainh5538 1 year ago ok -- cold and hungry 300 years life expectancy was like 55 ???? Reply @odedwolff3878 @odedwolff3878 1 year ago Okinawans eats lots of rice- lots of glucose Reply @manuelojeda9144 @manuelojeda9144 1 year ago Resveratrol doesn't do what Scientist Sinclair claims. Reply @13Floresj @13Floresj 10 months ago Thanks Reply @linyan9299 @linyan9299 1 year ago 这些专家学者可能也仅仅是做了对比统计，从分子水平上到底身体发生了什么他们并没有讨论，只给结论的做法不是科学研究。 Reply @jonathanthompson2704 @jonathanthompson2704 1 year ago problem with pure vegetarian diet is lack of b12. You need b12 for your brain. Reply @iwdevelopers @iwdevelopers 1 year ago Has anybody tried YTE? Reply @paulocoutinho9133 @paulocoutinho9133 1 year ago I heard for almost one hour and didn’t listen what/when to eat Reply @framestomind7548 @framestomind7548 1 year ago Social structure? Exactly what social structure are you talking about Sinclair? Have you been to Okinawa today? Is modernized! Reply @j.r.kizziar9493 @j.r.kizziar9493 1 year ago 🔥 Reply @j-rey @j-rey 1 year ago I think about a horse. Such a big animal. And I don't think they eat meat. Hay and grain. Fruit. Veg. Reply @loaded6856 @loaded6856 1 year ago Raw foods lou corona 1 Reply @annabelalford804 @annabelalford804 1 year ago Why don't you consider a ketogenic diet to be a starvation mimetic?? Reply 1 reply @robertplant6592 @robertplant6592 1 year ago ok. What about beer? Reply @ashtongrist @ashtongrist 1 month ago you'd think he'd do something about the nose being a multi millionaire Reply @r.b.somers2052 @r.b.somers2052 1 year ago Is it me or does David resemble Mark Pellegrino (Lucifer) from Supernatural? ;-) Reply @malkyhendry6560 @malkyhendry6560 1 year ago These 90 year olds look great Reply @jpprovost64 @jpprovost64 1 year ago Yes but when we are like me .. a sportifs competitioning ? Reply @noemisaid9162 @noemisaid9162 1 year ago 😧 what about carnivore people they claim veggies is bad por us ….. I am confuse Reply @proudchristian77 @proudchristian77 8 months ago Vegetarian diet works u know , add exercise & whallah!, Reply @a.aaliev4033 @a.aaliev4033 11 months ago Shetty, Ashok K.; Kodali, Maheedhar; Upadhya, Raghavendra; Madhu, Leelavathi N. (2018). "Emerging anti-aging strategies - scientific basis and efficacy (Review)". Aging and Disease. 9 (6): 1165–1184. doi:10.14336/ad.2018.1026. ISSN 2152-5250. PMC 6284760. PMID 30574426. Reply 1 reply @jojohnviz12 @jojohnviz12 1 year ago What the nation of Islam has been saying since the 40s basically 🤣 1 Reply @elizabethmirakian2563 @elizabethmirakian2563 10 months ago I do not like the idea of stressing any living being! Even plants! Reply @susancolman7911 @susancolman7911 1 year ago Who knows Keto or vegan So confusing Reply @emilee_7265 @emilee_7265 1 year ago Vegans eat a lot of sugar, carbohydrates, at depends what you exactly eat, not that you are vegetarian, vegan or something else. A lot of Vegans are sick, or I know people , they are dont live anymore... so big anemia have they had... I am vegetarian , but I eta a lot of eggs, Cheese, Fisch, when you eat OMAD you must have high density food! And Vegan food is very difficult thats to find..... Reply @violetka1197 @violetka1197 9 months ago dietary mediterranea...........PASTA AND PIZZA...HAHAHAHAH Reply @partlysimpson5154 @partlysimpson5154 1 year ago business man Reply @Zar4thustr4 @Zar4thustr4 10 months ago (edited) that protein info is a bummer : / so its muscles or a long life ... 1 Reply @amorenoorskitchen7732 @amorenoorskitchen7732 10 months ago Wow he looks so young and handsome Reply @naveedkhan1332 @naveedkhan1332 1 year ago Only focused on red meat...no word about pasture raised red meat...huge difference between grain fed and pasture raised red meat ... Reply @jdxx59 @jdxx59 8 months ago Damn - lost me when he started citing the Adventist study whose research is biased and steered toward plant based foods. Reply @edwardbanegas2153 @edwardbanegas2153 1 year ago Cut the meat? And replace it with??? Reply @johnatkinson9530 @johnatkinson9530 10 months ago This talk would be much better if David wasn't interrupted over and over. Reply @kaynias8736 @kaynias8736 11 months ago Why are plant proteins better than meat proteins? Reply 1 reply @rainbowbutterfly6587 @rainbowbutterfly6587 1 year ago You said sugar is killer. How is the natural sugar from fruits? Reply 1 reply @shironbenyamini2798 @shironbenyamini2798 4 months ago OK - red meat bad. What about chicken? Reply @danilkopaskudnik3002 @danilkopaskudnik3002 1 year ago «du bist nisht geven in der floymen-aley, du zogst mir a lignt gor, se shmekt dokh mit epl fun dayn layb un mit epl fun dayne hor.» Reply @Zar4thustr4 @Zar4thustr4 10 months ago Indeed he does not look like 53 Reply @625098evan @625098evan 9 months ago don't cut meat if you're a very active person. just reduce it. Reply @balasubramanik4163 @balasubramanik4163 1 year ago Brahmins in India mostly don't eat after sunset Reply 1 reply @kierancasey1135 @kierancasey1135 10 months ago I couldn’t get passed the promo Reply @jacobh1114 @jacobh1114 11 months ago He does not look 53 Reply @letsgobrandonpodcast @letsgobrandonpodcast 1 year ago Bruh, you got jabbed... at least twice that I know of. Shocking stuff. Reply @aurorasanchez7922 @aurorasanchez7922 1 year ago thanks Dr. we want to meet yoir Dad Reply @Youarelight19 @Youarelight19 10 m Lifespan with Dr. David Sinclair #3 Exercise, Heat, Cold & Other Stressors for Longevity | David Sinclair 622K views 1 year ago Podcast Episodes In Episode 3 of the Lifespan Podcast, Dr. David Sinclair and Matthew LaPlante dive deeply into the science of non-dietary interventions that mimic adversity and promote health. They begin by highlighting how different types of physical activity (i.e., low-intensity aerobic exercise, high-intensity aerobic exercise, and weight training) protect against age-related disease and enhance longevity. David and Matthew additionally highlight the latest evidence behind hyperbaric oxygen therapy, cold therapy, and heat therapy. As they discuss different adversity mimetics, they also explain how these interventions influence aging at the molecular and physiological levels. … 1,023 Comments This was another great episode! Learning so much. Just sharing my notes here. Too much iron is dangerous for longevity. Drives the accumulation of zombie cells. Survival sensors: - Mtor: senses amino acids. Lower levels of BCAAs are good - Ampk: senses energy (glucose). - Sirtuins: sense NAD (goes up and down with food and exercise) Insulin tells the body that's there sugar to use. -Exercise prevents diseases. Reduces mortality. -Walking after a meal stimulates the production of new blood vessels and turns on ampk (registers energy -atp-). -Vigorous exercise. Low levels of oxygen (Hypoxia) are good (though doesn't feel good). -As we get older, our muscles become less sensitive to the insulin that the pancreas is putting out. This is due to aging. -glucose in the bloodstream damages blood vessels. -Exercise impacts epigenome (regulator of DNA). -80% of future health is manipulable and modifiable (epigenome) Weight training: - Maintain hormone levels, ability to walk well and have good posture, makes look better - Is hard to get muscle as you get older. - Breaking your hips is equivalent to have stage 4 cancer. Mortality rates are that bad after hip injury. ○ How to avoid breaking hips? Build muscle and work on flexibility. - Senescent cells: when the epigenome becomes deregulated, cells can either die or they can be shut down, so they are zombie cells. Slowing the formation of zombie cells or killing them is important. Exercise kills these cells. Hyperbaric Oxygen Therapy (HBOT) - Hyperbaric chamber where pressured is increased. - Can reverse aging. - It's similar to hypoxia. So it's similar to exercise. Cold Therapy - Production of brown fat (burns white fat and enhances metabolism). - Cryotherapy, cold showers, sleep with few blankets. Heat - Saunas reduce 20% in cardiovascular disease. Let me know if you want me to keep posting these notes, I am on Twitter @juampiaranovich 344 Reply 33 replies @saptarshisarker @saptarshisarker 1 year ago This is the only series of podcast which I watch from starting to ending without skipping. Thank you David sir for all the knowledge 🙏🏻 147 Reply 6 replies @AboodCohen @AboodCohen 1 year ago (edited) What an exciting era to be alive thank you professor Sinclair! 114 Reply 5 replies @ginavanulzen6681 @ginavanulzen6681 1 year ago As an Exercise Physiologist I applaud how accurate the exercise based information was! I did a little cheer when he said ‘no one type of exercise is the best’, because people are constantly saying there is a secret special exercise that fixes it all. 58 Reply 8 replies @bestrongandloveyourself2370 @bestrongandloveyourself2370 1 year ago I love this podcast so much! 🥰 I work out everyday, but I prefer short 15-20 minutes workouts and 20 minutes stretches, and it is hard for me to work out 1 hour at a time and then do stretches, I just don’t have time for that. So it is good to know that 15 minutes per day can be enough ☺️ Plus, I walk every morning for 30 minutes. I should be fine 😁 Thank you for making me feel good about my routine! 🙏❤️ 29 Reply @catsteinhilb2880 @catsteinhilb2880 1 year ago I’ve loved and learned from every single one of these so far ! I am so grateful to you both. I really feel there should be a Dr. Sinclair health class taught at every level of education! Starting now. 33 Reply @robertbanks8076 @robertbanks8076 1 year ago Hi, great info and presentation. I am 72 years young and every new person I meet, find it hard to believe that I am really that age. I am ex military and have maintained my fitness throughout my life by keeping flexible and using my lungs with purpose. From my Army days I have always finished off my shower with full cold water. In recent times I have been using the Wim Hof Method of breathing and cold showers and exercises. It has taken me to a new level of energy and well being. My only medical complaint is a hole in my esophagus from acid reflux. I have nearly always only eaten when hungry, and usually only enough to satisfy that hunger, knowing it will take 20 minutes or so to get that satisfaction. Being human, there have been times when this wasn’t always the case, but I am not fanatical about it. It feels great to be alive. 236 Reply 18 replies @Pepemartiny @Pepemartiny 1 year ago Another great podcast ! It would be amazing though, if Dr. Sinclair and Mr. Matthew LaPlante could take some questions and dedicate 2-5min segment to them, either from comment section or submitted upfront. Good job 👌! 174 Reply 4 replies @ramiror8543 @ramiror8543 1 year ago OOOO MY GOD... I've been doing this for YEAR.. giving my stomach a break. Intermitted fasting for the past 24 year.. Im 53 in June and still in great shape. Thanks Dr. Sinclair.. Also im preparing for my MCAT, will be a Dr. soon myself.. 14 Reply @jaedanp9290 @jaedanp9290 1 year ago I just spent 4 hours learning how the mitochondria works because of this amazing episode ... Life is bazar. Thank you David & Matthew! 22 Reply 1 reply @averno9 @averno9 1 year ago "We don't have to run from predators very often. And this is a real problem" - Dr David Sinclair I know it's completely out of context but I found it hilarious. 126 Reply 4 replies @Cesc8170 @Cesc8170 9 months ago (edited) I am reading your book 'Lifespan'. Your written style is pleasing, funny, you go to the point, it's knowledge rich, and you are a very lively person. I feel lucky to be alive right now witnessing the development of this longevity research. What a gift you're building, David, among others. My most meaningful thank you. Really! 3 Reply @arnaldurbjornsson3638 @arnaldurbjornsson3638 1 year ago Premium quality content. Thank you so much Dr. Sinclair. Reading your book and listening to these podcasts has fundamentally changed the way I view human life and it's duration. 26 Reply 3 replies @mjk9388 @mjk9388 1 year ago (edited) I really LOVE this series. What would make the take-aways even better is talking about how many years each suggestion would likely add to your life IF that information is available (even if you have to infer that from the rat studies). Great job again on the podcast! Love the format and info. 9 Reply @brittanystorey9460 @brittanystorey9460 1 year ago Hey thank you both for this PodCast! I am trying to make a new life long routine starting at 26. Can't wait to track myself. 26 Reply 2 replies @siljaniemisto3390 @siljaniemisto3390 1 year ago Great podcast!!! ❤️ In case you could do Q&A in a future episode I'd love to know how pregnancy and breastfeeding affect ageing and whether the suggested protocols have been studied on pregnant and/or breastfeeding women. 14 Reply @slowmotouch534 @slowmotouch534 1 year ago Dr. Sinclair you are awesome! Thank you for the insights, very pleasant to listen to. I've been learning a lot from you. Thank you for the free information! 27 David Sinclair Reply @marcellocapone4925 @marcellocapone4925 1 year ago Phenomenal podcast series, and one I will definitely be re-listening, compiling bullet-point lists and drawing up action plans for myself and my family. Reply @alexkits2518 @alexkits2518 1 year ago Dr. Sinclair is always interesting. One hour goes so fast 💨 and the topics are so amazing 🤩 8 Reply @Wacoal34d @Wacoal34d 1 year ago This really really outstanding. Naturally with David Sinclair. Covering so much ground in a little over an hour is so useful. I think the 1 hour podcast will become the new standard. 1 Reply @dunlapfarms6517 @dunlapfarms6517 1 year ago (edited) I bet life insurance companies would love to get their hands on the death prediction data for people. Very thought provoking podcast, and I love learning the science behind it all. Thanks! 7 Reply @jameskirkland9429 @jameskirkland9429 1 year ago Great podcast. Would love to hear some commentary on how protocols and methodology changes for those that haven't started "getting old" yet 8 Reply @veraarena1583 @veraarena1583 1 year ago Excelent podcast, two intelligent brains, fantastic educative and pleasant discussion of very important health issues! Thank you!! 7 Reply @lyzabethlopez @lyzabethlopez 1 year ago Obsessed with this podcast! Recommending all my clients follow along too so we can all learn together and have discussions 36 Reply @KC53557 @KC53557 1 year ago Love the podcast, I’ve listened to many podcasts, initially with Joe Rogan. I read the book as well. I started taking NMN and Resveratrol a year or so ago. Prior to taking the supplements I got a blood test and determined my internal clock with Inside Tracker, a couple years later I Re tested my blood and my internal clock reduced by 4 years. Amazing! 20 Reply @ujjwalsingh8502 @ujjwalsingh8502 1 year ago (edited) -Have Low Levels Of Iron -Get Off Your Butt -Walk After Eating -Low Impact Excercise For 50 Minutes A Day 4000 Thousand Steps A Day (Walking, Running, Cycling) -Have A Hypoxic For Atleast 10 Min A Day; Recommendation: Do HIIT Or Vigorous Excercise 75 Min A Week -Bio-Tracking -Weight Training Maintain Muscle Mass Focus On Big Muscles -Hyperbaric Oxygen Therapy 90 Min A Day; Helps In Mimicking Excercise -Cold Exposure: Cold Shower Or Cryotherapy, Leave a Window Open While You Sleep, Put Fewer Clothes On And Move Out Specially In Winter, Etc. -Heat Exposure - Sauna Bathing Recommendation: Heat-Cold Contrast Shower Or Bath; 5 Or More Cycles 169 Reply 15 replies @isabelleebel8552 @isabelleebel8552 1 year ago Dear Dr. Sinclair, this podcast is amazing ! Thank you so much for your time and dedication! What a hightlight of the week! Unfortunately, the link to levels does not seem to work, would you be able to provide us with the right one? Thank you! 6 Reply @bicycleseatthoughts4405 @bicycleseatthoughts4405 1 year ago Absolutely love this channel. Reading the book, been listening to every podcast and you tube video since last May. Taking some of the supplements and at 46, I have noticed a difference. Thank you! This is the best thing to listen to while you walk you dog, folks. 3 Reply @thecelticgiraffe @thecelticgiraffe 10 months ago (edited) These are some of the most interesting podcasts I have listened to on anything health related. I am still not 100 percent convinced "vigorous" exercise is really that critical to healthspan, even though I totally agree it is good for you! I have at least a dozen people in my close family that are in their 90s and some lived to 100, while staying healthy. Of course I am aware that given the right method and environment we can live to around 120 and that is many modern peoples goal. But I think making it to 95 and still being able to have fun, feel good, and hike is really successful itself. They had a few things in common. They did not eat a lot ever (none were vegetarians or vegans). They used alcohol in moderation. Did not smoke. They stayed active as in cleaning, shopping, walking places, card games, family gatherings, cooking, working. They did not sun-bathe and hardly ever got angry. Not one of them took any vitamins, fasted, did vigorous exercise or cut out eating meat. I still say for them the most important factors were moderate exercise and not eating a lot ever. To me if you can do just those 2 things and nothing else, you are well on your way to long term health. However I also do breathwork exercises daily and I am a vegan. I highly, HIGHLY recommend both for optimum long term health and to just plain feel good! The evidence is overwhelming for both. 1 Reply @ruiyixu524 @ruiyixu524 1 year ago Thank you so much for the free education! And it's really not so hard to understand either for a layman like me. Right now I'm getting the key ideas and translating them and explaining them in details in Chinese, putting them in my blog hoping to convince more people cognitively to get more exercise including my parents. Now I seem to have very strong arguments to back me up! Exercise is so important. Thank you both, please keep up more updates. 1 Reply @andrespinzon6607 @andrespinzon6607 1 year ago (edited) Hi David! Great podcast, I have been following your work for years. On the other hand, having a standing desk injured me. I was standing half of the time and my foot got injured. I recommend doing 5 minute active pauses each hour instead 6 Reply @grlpeterson @grlpeterson 1 year ago Wow, I'm awesomely pleased to see Dr Sinclair with a podcast of his own! I've followed many podcasts he's spoken on. I'm glad to hear him say he skips breakfast AND lunch; just hope I'm doing the best for myself by typically doing so although sometimes I eat a package of seaweed in the early hours of the day or make myself a beetroot and chlorella powder simple smoothie to keep my body calmed. 2 Reply @alexgordin5041 @alexgordin5041 1 year ago Hi David and team, thank you so much for this podcast. It’s great! Do you think that recreational diving with nitrox (oxygen enriched air with 32-36 percent oxygen) will have an effect similar to oxygen hyperbaric therapy? 2 Reply @zanshin720 @zanshin720 1 year ago This channel is going to the Moon! I have watched every video and will watch every video. This information is more valuable then all the gold in the world! Thank you both for all you have done are continue to do. 62 David Sinclair Reply 8 replies @BarneySmarney @BarneySmarney 1 year ago Information like this should be spread to the masses. Thank you for your hard work & research! 3 Reply @tdmmnrdrk2830 @tdmmnrdrk2830 1 year ago (edited) I have listened to it breathlessly. Many thanks for making this channel available for us. I feel myself privileged for discovering Prof.Dr. David Sinclair years ago in Youtube. I have been amazed with the information he has been giving out since then. I try my best to follow his recommendations and yes they do work🥰. I have been always wishing that he would have his own channel. And here He is. I appreciate all the efforts being invested here. Wish you all in 2022 all the best. 1 Reply @AndresLaszloJr @AndresLaszloJr 1 year ago Very much enjoy your podcast. Thank you. If, approaching the last of my 20 hours of daily no-food, I fill my tummy up with something non-calorific (like water or husk), my hunger pangs will go away. My question is: As I make myself feel not hungry, what happens to the "body-believes-I-am-starving-and-switches-on-live-longer-effects?" Do the beneficial longevity "buckets" listen to my psychological hunger (and turn off): "He's not in starvation mood any longer," or physiological hunger (and stay on); "He is mistaken because, in reality, he is still in starvation mood? 3 Reply @VinayPatel3 @VinayPatel3 1 year ago Great stuff, thank you. I would love to hear your thoughts on the effects of mental stress and if those can be reversed, please! 2 Reply @leslietydings9516 @leslietydings9516 1 year ago Great podcasts! I was diagnosed in September 2021 with ALS and would love to hear your recommendations. I was very healthy, but was under extreme stress for 5 years and the gene C90rf72 expressed.I would appreciate any recommendations. 1 Reply @msmiller57 @msmiller57 8 months ago Such good info. Thanks you guys! I am sensitive to iron collection genetically. I donate blood to reduce it. Need to advise that seriously dark leafy greens (especially spinach) are extremely high in iron. Depending on your personal chemistry you might want to be careful about how much of these greens you want to include in your diet. It's all about understanding AND measuring your personal chemistry. Reply @OddMickel @OddMickel 1 year ago Excellent stuff! I love learning about the science of the human body. it's as fascinating if not more as other topics such as deep space or deep ocean. Who doesn't want to learn how to live longer? Amazing content from a trusted and likeable source. 1 Reply @bonnyking-taylor7204 @bonnyking-taylor7204 1 year ago What a relief. About 10 years ago, I was told I could not donate blood because my level was about 2.5 points too low. I tried to raise my level for a month and the iron made me so sick. I"m fine without it! 1 Reply @claudiafernandez3548 @claudiafernandez3548 1 year ago Dr Sinclair, Thank you for the time and dedication to share this valuable information. I appreciate it. 8 Reply @glendagiron3529 @glendagiron3529 1 year ago I feel 3 times much better then before I was taking NMN and other supplements thank you Mr David ❤️ 1 Reply @elenabenjamin9980 @elenabenjamin9980 1 year ago Thank you Dr Sinclair ! You don’t have idea how much I appreciated and love you for all great things that you are doing. ! I follow you and check up your need. Thanks again for makes the science for us , the regular people👍👏🏼👏🏼 1 Reply 1 reply @marcar7612 @marcar7612 1 year ago I totally love 😍 this podcast. Thank you for sharing such a valuable information. I would like to know if you have any data on fasting and experiencing female and thyroid unbalance after a longer period of fasting (7 days or more)? 🙄 Muchas gracias 🙏🏼 Reply @zedek_ @zedek_ 9 months ago (edited) It's particularly exciting to me that you covered the Hyperbaric Oxygen Therapy (though this whole podcast is incredible). It occurred to me that I already have a way of getting into hypoxia, with elevated levels of oxygen in my blood... Wim Hof breathing You mention at 55:48 that "going up and down" multiple times is better, but I wonder if you (or anyone else) can provide more insight into this? Is it merely sufficient to reach 'up,' or should I stay 'oxygenated' longer, I wonder? From how it feels , being a bit strenuous and stressful, I think it has some effect just by reaching 'up,' but I'm curious to see if there have been further findings on this. Edit: Ahhhh, 1:08:00 - perfect, yes. This is why I think merely going 'up' is good for me. I get that feeling of endorphins, so I'll just proceed by feel. Thank you! Reply @christinley5213 @christinley5213 1 year ago Im all ready addicted to all the wonderful info you both have here!! Keep up the great science guys!!:) 2 Reply @royzlatanestevez9843 @royzlatanestevez9843 1 year ago I'm so happy for my grandkids that they will probably see the cure of aging happen in their lifetimes (maybe when they are my age). It's a huge system engineered with many odds and ends to kill us in the long term. A truely sad state of affairs. For my wife and I, it will come too late. It's all falling apart under our feet. Allowed to see the promised land, but we shall not enter it. It's alright though when you know that others continue. 3 Reply @MiguelRodriguez-hk1yy @MiguelRodriguez-hk1yy 1 year ago Great podcast. Amazing scientific information. A lots of the information in this podcast regarding diets and lifestyles are spot on. I am currently living in Italy and I see a lots of people in their 90s looking like they are 60, full of energy riding bikes or walking everywhere. I see that most Italians dont usually eat breakfast, they just drink a coffee (espresso) and when they have lunch or dinner is not too much food, small portions and lots of vegetables. The Italians eat food in order (primi and secondo piatti) and then they have a digestive drink at the end. Eating in Italy or in the Mediterranean is an experience because the way is cooked (pasta cooked only a few minutes) and the way you eat and how is almost sacred because if you dont follow it people will look at you weird hahaha. And of course, every meal comes with the wine! I ordered Athletic Greens, I hope it taste good!🤣 2 Reply 1 reply @azadehkhajeheian9430 @azadehkhajeheian9430 1 year ago Love your informative episodes. Great job👏🏻 Reply @connieacevedo4709 @connieacevedo4709 10 months ago Another question, I absolutely love this podcast. Anyway, the question is, is crossfit 4-5 days a week a good regimen? I also swim two to three times a week, well let’s say I’m teaching myself to become a better swimmer. Reply @abdulrabbani4520 @abdulrabbani4520 1 year ago Great episode, I was looking forward to this episode all week! I usually watch all podcasts at 1.5x but I watched this at 1x so I could enjoy it longer :D 5 Reply @esramala78 @esramala78 1 year ago This discussion is so satisfying. This science is insanely interesting 🚀I want to turn on all the good turn off all the bad. I’m getting my lab work with inside tracker in the morning! Thank you for sharing 1 Reply @sarahsidney1988 @sarahsidney1988 1 year ago Watched this video while on my elliptical. The podcast sure kept me motivated!! 13 Reply @LouiesLog @LouiesLog 1 year ago (edited) I have been doing all this for years without knowing :) I ride my motorcycle in winter in the uk (cold) to the gym (exercise) then have a shower (heat) then back on the motorbike (cold). The motorbike also gets my heart pumping 15 Reply 3 replies @skram1000 @skram1000 7 months ago Awesome work you got going on. Love hearing about every bit! Reply @19Jetta @19Jetta 1 year ago My local spa has a sauna and cold pool (60 degrees F). I LOVE to cycle between them. At first, the time in the cold pool is brief, maybe 30 seconds. But as I keep doing it, I can eventually stay in long enough to do some stretches and use their waterfall (it cascades out of the wall) on my shoulders. For me, I do it because it helps with muscle soreness. But also, I do come out of it feeling very exhilarated yet very relaxed. Now I understand why. 3 Reply 1 reply @chrispyscampingadventures @chrispyscampingadventures 1 year ago (edited) This is an excellent podcast. Really enjoying the episodes 4 Reply @karinak3487 @karinak3487 3 months ago Love you guys for such a priceless info!!! Beyond thankful 🙏 ❤ Reply @TimeRiderTime @TimeRiderTime 1 year ago Great, clear information! Thank you, as always! So many questions was answered! 4 Reply @pogbert1 @pogbert1 1 year ago Last Friday I hit ten gallons of blood donated since 1993. I was doing it to help others. Nice to learn it helps me too. Thanks for all you do. Reply @Babyy_girl @Babyy_girl 1 year ago I would be very interedted in the correllation between reproduction and "preventing aging" Espechially after childbirth, what goes on in the mother's body and how does it affect her biological age? That would be so interesting and helpful for so many of us!! Reply @maynardmg-photography8670 @maynardmg-photography8670 1 year ago Great podcast on survival mechanisms that may help us to live healthier and longer. By the way have you guys consider doing the podcast using standing desks/ tables? Reply @Goalieswede @Goalieswede 1 year ago Great episode, couple of follow up questions: How much iron is too much? If I can afford the blood test, what numbers should I be looking for as a male? What should the timing of the heat/cold exposure be in relation to exercise? Distanced from it or immediately around it? 7 Reply @5MinuteBody @5MinuteBody 1 year ago I'm just starting to introduce cold therapy. Its super hard to start but I know it makes me stronger, both physically and mentally 🤓😃 2 Reply 1 reply @DrBradShook @DrBradShook 1 year ago Amazing work! I really appreciate the sharing of your knowledge and time. 6 Reply @AmyLe01 @AmyLe01 1 year ago Thank you for your useful information. Have we also look into mental health which can be an important contributing factor to aging in addition to our physical health such as when you are living in a toxic relationships which cause you severe insomnia over a long period of time Reply @Midhun0906 @Midhun0906 1 year ago Been following you since your episode in Tom Bilyue's show. The way you explain things in awesome. Thank you for sharing your knowledge. 1 Reply @JuDarius @JuDarius 1 year ago (edited) Thank you for this great podcast. I have a question about your sponsors and your diet David: Normally before I start to take supplements it makes sense to have a extended overview of your blood records to better understand what you miss as individual and then I can decide on what I have to supplement. With athletics greens I just take a general Dosis of different supplements ignoring that I am an individual / different diets and have different demands then someone else. 2 Reply 1 reply @nprakaash @nprakaash 1 year ago David, it would also be helpful if you could talk about impact of breathing techniques on ageing. Breathing exercises regulate oxygen intake into the body. 1 Reply @Ccowdog1 @Ccowdog1 1 year ago I listened to David on other pod casts - im so glad you have your own - I learned so much from you - and explaining it to us in a logical simple way that makes sense . I would love for you to do a ipod cast for woman hitting medipaus and why we have hot flashes and what causes them and how to get rid of them if possible. I applaud you ! Thanks again you made a difference in my life and your advice in incredible! Reply @captainpike2468 @captainpike2468 1 year ago David is one of THE best science on the level understandable to the layman - 4 Reply @pacosamo @pacosamo 1 year ago This podcast is a true public service. Thank you. Can you please talk about how to prevent glycation? 1 Reply @giopuma @giopuma 10 months ago Being a scuba diver, I am fascinated by the hyperbaric chamber experiment. Since a dive is typically a "workout within a simulated hyperbaric chamber", I wonder if (setting aside the risks involved with diving), scuba divers do get the benefits described in the experiment. Any excuse to dive more is welcomed :-) Reply @flyingsneetch @flyingsneetch 1 year ago Thank you for this amazing information! I was wondering if you had any information regarding using Breathwork such as the Wim Hof method or Buteyko breathing to induce hypoxia. Is the hyperventilation / hypoventilation we see in Wim Hof doing the same thing as the Hyperbaric chamber you mentioned, due to the large differential created during the practice? Thanks again! 6 Reply @user-js5ly2wx4l @user-js5ly2wx4l 3 months ago (edited) Great discussion. Also would be interested to know whether lean muscle and being slim is the ideal body type for health and longevity (So an Olympic athlete built (in general are lean and slim)/tennis player physique vs bodybuilder where we're mis-sold as being healthy and strong). Also, given that low body fat and waist circumference levels is also ideal for longevity, what would be the ideal BMI to aim for in general. Any studies on whether those at a specific range of BMI live the longest and age gracefully into older years without chronic diseases? Just looking at other countries, cultures, and reviewing some studies, my thoughts are that the lower end of healthy weight range so between 18.5 to 22 or 23 is the ideal weight for longevity and too much muscle or body fat that exceeds out with this range will result in diminishing returns. Reply @ericmikkelsen @ericmikkelsen 1 year ago Do glad you're continuing to keep us up to date! Thank you so much! Could you please put together a terminology glossary that could be understood by a lay person not in your field. 1 Reply @lairheron9489 @lairheron9489 1 year ago Dr. Sinclair and other scientist in his field that are tying to solve aging are literally doing the most important work in modern times. We'll have to solve our short life spans if we ever want to explore the cosmos and visit other worlds. 3 Reply @ci4396 @ci4396 1 year ago 3 months later rewatching this and quite surprised that david sinclair doesnt have sauna and icebath at home. after hearing this episode i bought an infrared sauna instantly and 2 days ago i finally took delivery of my personal icebath. lowest temp the machine can achieve is 5 degress celsius / 41 fahrenheit, but ive started with 10 celsius for 10 minutes. feels amazing. if youre priviledged enough to live in a country with cold mountain water and water heaters, you could probably fill your bathtub with cold water and stand under a hot shower. sadly i live on a beautiful island, where the coldest water you will find is around 30 celsius :-P 1 Reply @milovee1238 @milovee1238 8 months ago I'm 82 and looking for mitigation strategies for aging I'm on no meds and would love to be part of a study with people my age actually doing some of Dr Sinclair's recommendations to see how well they work or do not work. Also I know Hyperbaric is different than breathing supplemental oxygen but shouldn't that also be explored as a cheaper alternative. Reply @santerihiitola @santerihiitola 1 year ago In fact, that hot-cold-hot-cold routine with sauna is actually quite an integral part of the experience for many Finnish people. Typically people would either roll in the snow or take a dip in a hole cut into a frozen lake or sea. 1 Reply 1 reply @ronnyzetterstrom9727 @ronnyzetterstrom9727 1 year ago (edited) Thanks for a interesting series. So I wondered in regard to calorie restriction, should one not eat anything at all until dinner, if one is to follow Dr Sinclairs model? What is considered fasting? Water is ok I presume. How about coffee? (Also what is your take on the use of caffine?) Also, how would one keep up their energy level during a work day? With regards, Ronny. 3 Reply @biplobpaul9073 @biplobpaul9073 1 year ago I love you David Sir. Keep bringing us some good information. Reply @ericwiese7479 @ericwiese7479 1 year ago Dr. Sinclair thank you for your information. Loving the podcast too. 5 Reply @sonnymatthews5452 @sonnymatthews5452 1 year ago Questions - How many Hyperbaric oxygen sessions a week to see a benefit? How would a high-intensity hybrid athlete manage a fasting protocol? thank you for all your information on this podcast. 1 Reply @lamouralice4533 @lamouralice4533 1 year ago omg hypoxia actually is something that I am feeling it myself that's works! Thank you so much for bring this up💜, I really feel that have a lot to do with qi kung and hydrogen related benefits! So grateful for all this boardcast！ 1 Reply @chrisupcroft7864 @chrisupcroft7864 1 year ago It is crazy anyone can come and get this information for free!!!! Thanks so much for putting these together. 1 Reply @edenlee8932 @edenlee8932 1 year ago It would be great if you could cover some more in-depth effect of cold and heat as hormetic stressors. Reply @pankajjha000 @pankajjha000 1 year ago Hi David I am a big fan of works you are doing and bringing it to public domain. Do you have any studies to point out any benefits from Breath Out Apnea Walk? Does any protocol based on it provide any kind of benefit to the markers of ageing? Reply @flankerjoesgaming3621 @flankerjoesgaming3621 1 year ago Thank you so much for what you do Dr. Sinclair. In regards to walking after eating, I personally fast until late afternoon when I then exercise before I eat my first meal shortly after. Is my body already in the AMPK state or should I go for a walk after my meal still? My exercises vary between strength and cardio but I always eat soon after. 12 Reply 3 replies @efilnikufesin @efilnikufesin 1 year ago (edited) Glad you are directing us to the right path to longevity. Cant wait for the next one. 3 Reply @natalieaxl804 @natalieaxl804 1 year ago Anti-aging and Longevity is Priceless!! Never stop investing in yourself. THANK YOU DAVID 😊 💓 6 Reply 1 reply @ElizabethRider @ElizabethRider 1 year ago Great episode! Looking forward to the next one 😀 2 Reply @catalinmuresan3230 @catalinmuresan3230 1 year ago Wonderful episode! I have a question: can you overdo it in regards to exercising? If you are keen on running marathons for instance, does that affect you or lessen the positive effect of exercising? 1 Reply 1 reply @roberttowner6326 @roberttowner6326 1 year ago man this podcast is very good. looking foward for the next ones. subbed 2 Reply @PrinceOfBabylons @PrinceOfBabylons 1 year ago I feel younger when I watch this interview, awesome people keep it up good work 👍🏼 4 Reply 1 reply @PssupplementreviewsbyPete @PssupplementreviewsbyPete 1 year ago This Mathew fellow is brilliant, but it took about half episode to realize. He's perfectly goofy and sharp as a tack. Great combo! 2 Reply @TommyGuichardo @TommyGuichardo 1 year ago What a great conversation with so much information. 1 Reply @Laflaqua-hg5yx @Laflaqua-hg5yx 1 year ago (edited) The conversation about iron is certainly an interesting one... I've always been too low (or even deficient) in iron. Always had low glucose, low blood pressure and been skinny. Never liked too much sweets or sugary things and I tend to eat little portions until I'm satisfied. And people think I look on average 10 years younger than I am! Now we know why! haha Reply @karimmanjra @karimmanjra 1 year ago Great! Love it! I've discovered your work through an interview with Huberman not long ago. And this serves as a segway to my question. If I'm not mistaken one key take-away I got is that growth hormone isn't that great for longevity. In today's episode you've talked about how you alternate sauna and cold bath. I've heard of many studies that showed that this increases like crazy our growth hormone levels. I feel like I missed somehting. Can you please help clear the haze? 2 Reply @KrisSoprano @KrisSoprano 1 year ago Thank you and keep up the good work. It is really appreciated. 1 Reply @robin-jewsbury @robin-jewsbury 1 year ago Great that you mentioned iron overload. Please keep talking about it. I have hemochomatosis and researching peoples DNA with the age at with those with hemochromatosis mutations get ill. I’m seeing patterns where not only iron metabolism genes modify loading speed but the metabolic diseases also affect loading speed. It’s all in the data; I have nearly 1000 DNA samples so far from hemochromatosis sufferers. 4 Reply @Pekka.Sundman @Pekka.Sundman 1 year ago Great podcast. Thank you! Is it possible that reversing the age (by NMN, resveratrol, Metformin, exercising and fasting) your body can also repair eg. ostearthritis or osteoporosis? 3 Reply 1 reply @RunToTheHills999 @RunToTheHills999 1 year ago Amazing series. Can't wait for the next episode 3 Reply @lisamitchell3116 @lisamitchell3116 1 year ago I’m looking forward to the studies on the ‘20% genetic which we can’t do anything about…yet’. The Bruce Lipton’s and Joe Dispenza’s and spiritual gurus should join together with you! 2 Reply @marinafoglietti9351 @marinafoglietti9351 1 year ago Thank you a lot for all these interesting informations. I have began to assume Reveratrol, I practise sport at home for 20/30 minutes three times a week in the afternoon; sometimes I go out for walking, not all days, but I never stop moving at home. I wait for the next post.😍😍😍🇮🇪 1 Reply @jorgesancheztarango8990 @jorgesancheztarango8990 1 year ago I just have to point out that the piriformis muscle does not go through the obturator foramen “whole in your pelvis” 18:05 It’s my role to point this out. Great information! Thank you 2 Reply @vickydaisy1905 @vickydaisy1905 1 year ago Love all of your episodes. Thank you so much 😊 4 Reply 1 reply @SquatFull @SquatFull 1 year ago I'm 73 years old and have engaged in resistance training for over thirty years. My current exercise activity and nutrition focus on slowing the process of sarcopenia and the decline in other physiological functions. I have used supplements to augment my food diet. Currently, my supplements concentrate on the mitochondria. Your "Lifespan with Dr. David Sinclair" Youtube series is excellent. Reply @kennylo8423 @kennylo8423 1 year ago Can't get enough DR! THANK YOU! YOU ARE CHANGIN LIVES ! 2 Reply @callofthedark @callofthedark 1 year ago Here we go.. after listening to the entire episode3 on Spotify 2 hours ago..waited for this here..One more time.. Cheers to taking another step towards a better future for humans evolution 8 Reply @TylerEidt @TylerEidt 1 year ago Thank you both for this great informative series! I do have a question. David, you mention how you take Athletic Greens every morning and yet you say you only typically have dinner as a meal each day. I am considering adding Athletic Greens to my diet but don’t want to disrupt the benefits of IF. Am I able to have this product in the morning during that window of fasting? Cheers! 2 Reply @dr.sammypryor @dr.sammypryor 1 year ago (edited) As a naturopathic doctor, my profession has known about all these "adversity mimetics" from the beginning of our profession. In school, I learned about hydrotherapy which includes many cold and hot treatments to the body. I hope one day to have a clinic in which I can do hydrotherapy treatments for my patients! Please tune into my channel to help support this goal of mine! Reply @beastie1996 @beastie1996 1 year ago This is my favorite podcast, 2022 will be great 12 Reply @beatusaestate1778 @beatusaestate1778 1 year ago Thank you for all the interesting information. Some questions for the next episode: In what quantities and time intervals should a typical person take the supplements? Is is for example bad to take NMN every other day or only a few times every week instead of every day? For how long will the different supplements remain active in the body after ingestion? What happens if a person overdoses with a supplement? What are the dangers or positive synergy effects of combining different supplements? 4 Reply 1 reply @BlueBellGoPro @BlueBellGoPro 1 year ago Hey David , not sure if you answer these but I have started to use NMN along side hot/cold therapy , HIT running , running , walking , heavy weight , light weights and sports. I have always been fit as well as played high level sport and been a competitive bodybuilder. I am know 43 and purely have a lifestyle dedicated to longevity. My BF is low , VO2 max 52 and RHR 48 , 5’ 10 , 82 kg. The reason I have given you some of my past & stats is NMN gives me immediate surge of energy , pump in the gym and a feeling of euphoria more so than a combo of creatine & caffeine which is surprising but I just can’t understand why it has such a extreme effect on me ? The only drawback is sometimes it’s almost impossible to sleep which has left me ONLY taken NMN early on in the day. Could this be because of my extreme muscle & fitness background from the age of like 10 ? If so does it have something to do with my mitochondria and metabolic flexibility? I am keen to know as it can panic me a little getting the strongest reaction I ever had from what should be a more subtle substance ? Reply @Olmirz @Olmirz 1 year ago (edited) Great Video! Thanks for taking the time to share this! One screaming question from me: does holding your breath put your body in a stressed state and provide similar benfits to hypoxia from exercise? E.g. Wim Hofs regiment Obviously within reason, so you don't starve your brain of oxygen, say 2-3 minutes at a time? You clearly wouldn't have the other benefits of exercise (muscle mass, testorone etc) but the logic seems it indicate it may help so at the very least worth investigating? Cheers, Ollie 1 Reply @singhashon @singhashon 1 year ago to get more subscribers and views because people are really interested in this subject matter.... you guys need to activate translations or get voice overs for other markets like the Russian/Chinese/Spanish/Indian/french... awesome channel and information so far guys.... keep rocking on Reply @davidkim6249 @davidkim6249 1 year ago Thank you sir for these amazing podcasts !!!! :) 2 David Sinclair Reply @leoatansil3704 @leoatansil3704 1 year ago This is a shot with fully loaded information. Can we say body building and longevity are two different goal of life ? Or can we achieve both ? 5 Reply 2 replies @Sunnysue31 @Sunnysue31 1 year ago My Dad was still running marathons in his late 70's ... He ran everyday ... had two hip replacements ( he wore them out).... His was the fittest person I know.... Sadly at 88 he now has Dementia and is very frail ... It all happened in just over a year !!! 2 Reply @nickl826 @nickl826 1 year ago David, could you please outline what constitutes as a high iron intake for each age milestone on an average person? (I appreciate not everyone fits this category). I.e. 30 year's of age, 40 year's of age, 50 year's.... I'm sure many of us would highly appreciate this information. Thank you. Reply @lisafalanga8457 @lisafalanga8457 1 year ago At 57 & 1/2…I am making progress❣️Blessings to you, Dr. Sinclair..Staying close to your podcast, Here, Lake Tahoe, NV🏔 6 Reply 2 replies @svenssvensson9024 @svenssvensson9024 1 year ago (edited) You guys got one important thing wrong. Back in time when humans lived in the nature we were mostly less stressed. Today with all this media, loans, divorces and so on keeps us stressed constantly. That is what makes your body lose the balance together with process foods and no outdoor exercise. Keep up the good job in analyzing our genes and our inner game. 2 Reply @TheCyclesport @TheCyclesport 1 year ago I like it when you do the advertising - business regarding the sponsors of your podcast, and your eyes lock into the wording as you read the data and the stare forward and the eyes look all serious and locked into each letter. As you talk about getting younger as you take trips around the sun! My mindset too 👍👍 Reply @gregorygabriel31 @gregorygabriel31 1 year ago Can you comment further about iron consumption? I did an inside tracker test and mine was slowly below optimal so I’ve been looking for ways and have increased consumption a bit through my plant based diet but want to be sure I’m not overdoing it. Any recommended daily amounts based on body weight or more specific guidance you can give? 5 Reply @jonmagee1778 @jonmagee1778 1 year ago Fascinating 🤯 Great Job with this series! 1 Reply @danbuckles2745 @danbuckles2745 1 year ago I was taking Donotage NMN and resveratrol every day and wasn't feeling well so I stopped and felt better. I take Vital Proteins, two scoops and I exercise 60 minutes 6 days a week which consists of doing X3 with bands which takes 20 minutes, a 20-minute abb work out, and walk at 3.2 MPH at a 2% grade for 20 minutes with a 15Lb weight vest which is really strengthens my legs to where walking for 4 miles without the vest is nothing and I feel great. I think clearly and at 74 and my reaction time is very good when driving and still can run around with younger adults. I'm losing weight and gaining mass which is really nice. Some people don't believe my age when I tell them. 1 Reply 1 reply @storbokki371 @storbokki371 1 year ago I use to run track and then 5k and 10k road races a lot when I was younger in the 1970s and 80s, My last 5k was 2015 at age 54. I remember reading somewhere about distance runners actually having more blood volume, but less red blood cells and more white blood cells than average, because a runners red cells, lungs and circulatory system was much more efficient. 1 Reply @thepantelemon @thepantelemon 1 year ago Thank you for the video! I've been thinking about hypoxia and breath exercises like in yoga, the one with halt after you breath out, this should led to hypoxia and all benefits associated with that, right? Reply @user-nu4lm9lv7m @user-nu4lm9lv7m 1 year ago 非常感謝🙏辛克萊博士的分析解說，讓我們得到很重要的健康長壽秘訣。 我已經吃素食幾十年了，的確對身體健康有很大的幫助，且也在吃美國研發科技產品SOD+NMN等，女兒說我變年輕了 Reply @devongarcha6096 @devongarcha6096 1 year ago It would be really cool to hear about if breathing has any effects on longevity such as breathing through the nose and breathing less 4 Reply 1 reply @jimmycheung3298 @jimmycheung3298 1 year ago Amazing to learn about the science behind Wim Hof's entire practice! 2 Reply @davewhipp5051 @davewhipp5051 1 year ago Excellent information - thanks. However, as a "Hoffer" I would love to know David's opinion on the Wim Hof method esp his breathing exercises going from hyperventilaton through to the extended breath holding. Reply @SpiritMatter-qo3jj @SpiritMatter-qo3jj 3 months ago Many CoViD19 patients were hypoxic and their health was amazing !! Reply @nossferatu3288 @nossferatu3288 1 year ago Thank you for the rich information you are giving. I have a question about fasting- I always do a 3 day water fast every month. Does this offer the same longevity effects as daily intermittent fasting? Appreciate feedback from anyone 😅 2 Reply 1 reply @gregcleveland8806 @gregcleveland8806 1 year ago I have a family member who had a hemorrhagic stroke at 28. Doctors have no idea where it came from. She’s now left with a life filled with the results of the stroke. Really bad aphasia and her right side of her body hardly functions at all. Does your research include this kind of issues? Any hope for us? Meanwhile, thanks for what you do. I’ve been reading and listening to anything of yours that I can find. Thank you. 2 Reply 1 reply @Freed0mOfS0ul @Freed0mOfS0ul 1 year ago I love this podcast and everything about staying young as long as possible , but I thought of something recently , I would NEVER want to live as long and outlive everyone I love , nope , especially my wife and daughter , mortality has many wisdoms , and "everything that has a beginning has an end" As Agent Smith Said in the Matrix lol , Watch the green mile , tom hanks in that movie his character lived to 108 and was still going he outlived everyone he loved , and it was sad , BUT all being said the way I live is not to die, the way I live is dying to live 5 Reply 1 reply @octavioflores8830 @octavioflores8830 1 year ago Thank you so much for this great information. You are brilliant 👏 2 Reply @kamlajohnson6226 @kamlajohnson6226 1 year ago Incredible. Thanks for sharing your knowledge. 1 Reply @joesansalone8234 @joesansalone8234 1 year ago (Binaural beats) MEDITATION - increases heart rate variability, lowers cortisol, increases DHEA. I noticed with exercise, I can push harder and recover faster than before I started meditating. Also, people get that "HIGH" right after doing binaural beats MEDITATION. I noticed a strong correlation between Heart Rate Variability and Emotional Resilience. Maybe you can have your mice put on headphones with binaural beats meditation and measure biomarkers for aging!! kidding .. unless you know of tiny special mice headphones. :) 2 Reply @auntiemichelleoutdoorsygir9909 @auntiemichelleoutdoorsygir9909 1 year ago (edited) Insightful information. I think you both should have a stand-up desk while doing this podcast. You teach about how good it is for the body to move, why not use it? ;) Reply @yairasayag3913 @yairasayag3913 1 year ago Hi David, You speak about the importance of building muscles through weight training, but how does it fits with the fact that you need to ingest amino acids for that purpose? As I understand from your podcast, you need to keep your amino acids low. But as far as I know, you gotta have amino acids to build muscle. Thank you 2 Reply @user-tm1ec2on6w @user-tm1ec2on6w 1 year ago Swim a mile every day, 50 minutes in a sauna, then five minutes in an ice cold shower. My energy levels and feeling of wellness go through the roof. 3 Reply @jamalmeliani6527 @jamalmeliani6527 8 months ago I’m 49 and I always had problems maintaining a normal testosterone levels even with medication and heavy weight lifting, and have discovered the only thing that would raise it up to a normal level for me is alternate days fasting, I fast for 24 hours and I eat 3 meals in the next 24 hours, this lifestyle it really make me feel like 20 years old boy sexually, usually results are seen after second week, Note: I do dry fast no fluids no food. Reply @divijrao955 @divijrao955 1 year ago Hi David, You mention the iron from meat. I'm pescatarian, however I love beetroot juice and in the last 2-3 months have been drinking about 1 litre per week. My blood iron and haemoglobin was normal, but I wonder if this might cause me to start having an overdose of iron. Any thoughts on this please? - deeply appreciated. 1 Reply @sawzz3303 @sawzz3303 1 year ago Hi prof, would like to know whether hyperventilation followed by breath hold (hypoventilation) has the same effect as those mentioned in the video? Thank you. Reply @Articulate99 @Articulate99 1 year ago Always informative, thank you. 1 Reply @diseasehealthdiets136 @diseasehealthdiets136 1 year ago Thank u so much! dr David sinclair .. Ur all episodes so amazing which giving us deep knowledge for long life..sir! i want to know that all human cells made by DNA, it synthesise due to many important molecules,Such as aminoacids minerals.. But is oxygen more imp. than other for long life cell.. Reply @Janaitisofficial @Janaitisofficial 1 year ago Thank you so much to both of you. I'm 41 years old, originally from Philadelphia now living in Finland. Im playing music here with legondary rock and roller Andy McCoy but recently times have been tuff due to Covid and I have not been taking advantage of doing the things I should to to maintain my health. Nothing bad, just mostly sitting around and not getting proper exercise and not using the Sauna's that are available here in Finland. Because I have been watching these pod cast episode's, I have been motivated to learn and start to implement the simple strategies you discuss. I'm looking forward on the next pod cast and if there is any way I could chat with either of you about my health and what I can do to not only better myself but also help people around me and spread the knowledge I would love to. Thank you, Kiitos...Matthew. 4 Reply @cjcj2010 @cjcj2010 1 year ago (edited) Funny, i let my daughter bleach my hair early on in the "pandemic." It turns orange after only a few washes after coloring. Using Surya Cream Henna. Really easy on the hair. Your hair looks natural from here. Thanks for all of the info! Reply @christinemarjeram4309 @christinemarjeram4309 1 year ago Thank you for the podcasts especially on eating and iron levels. I have a super high B12 level since changing from vegetarian to a meat eater. I'm now wondering if this is good for me! 2 Reply 1 reply @nenifood @nenifood 1 year ago I have a question: I've been fasting (intermittent) since a few years now. I just purchased Athletic Greens as per your recommendation. Can I drink it in the morning or will this break my fast? How do you do it if your only having dinner? Do you only drink it before your first meal of the day? Thank you guys for doing this podcast learning so much Reply 1 reply @abdulahadkhan3100 @abdulahadkhan3100 1 year ago Nice 👍, listened full episode, kindly mention if you are available on podcast or any other medium, if you can display episode no as well pls, it honor to listen such a personality Reply @adamjones9600 @adamjones9600 1 year ago I bought a portable pop up sauna off Amazon a couple months ago because I have a home gym now. It's great! Only a couple hundred bucks, I run it at 150f for 45m while I watch this podcast lol. It heats up so fast compared to a traditional sauna. Reply 1 reply @waynecutler3830 @waynecutler3830 1 year ago You're amazing, thank you for all you do :) 6 Reply @Ruudwardt @Ruudwardt 1 year ago I learn so much. However I wonder, there has to be a line from which point on exercise or otherwise physical strain will have adverse effects for longevity, just a gut feeling. I have no comprehensive measured data, however I register as best as I can everything with my senses and introspection. I do all of those 'uncomfortable' routines (excluding o2 chamber) and all of those I enjoy. What I find is that if I do a proper sauna evening (I live in the North-East EU) and, jumping into snow or cold bath is pretty standard after that, a full weight training session on the same day strains my body over my limit a bit. The next day I would be moderately physically exhausted and not very eager to lift weights. The effect is not too unlike overtraining. Essentially my question is would overtraining be considered beneficial for anti-ageing and if not, is simply training at ones 95% potential ie few sets short of overtraining per week also not so good? 1 Reply @explorersoftheworld1193 @explorersoftheworld1193 1 year ago thank you for very valuable and useful knowledge, I would be interested in the topic of fertility in women, how to care for it and whether it can be kept Reply @Margics @Margics 1 year ago (edited) Hi David 💪 my fave Professor 🤓 Micci here. Great podcast! About the exercise for more impact on n hormone production testo, estrogen and HGH it’s best full body exercises, multi–joint recruiting the most muscle mass as possible in one exercise eg deadlifts back squats, pull ups.💪🏋️‍♀️ take care. I will check all episodes.. gotta keep young .. I am wasting away 😬✌️ Reply @mikezimmermann2908 @mikezimmermann2908 1 year ago Regarding sauna bathing, Dr Rhonda Patrick has cited a study that says the optimal temp/duration is at least 176°F for 20 mins, 3 times a week. Thanks for these great talks! I've really enjoyed Lifespan as well! Thanks to you, I have joined Inside Tracker, which has been very helpful, and I'm also taking NMN and rsveratrol (500mg/day each to start). Keep up the great work, and thank you! 🙂 Reply 1 reply @ligiasommers @ligiasommers 1 year ago (edited) I wait for this podcast as my favorite one 🙏🏻✨🌹⭐️⭐️⭐️⭐️⭐️ps: I take AGreens and love it 🥰 2 Reply @drpriyankamehta @drpriyankamehta 1 year ago This is such an important podcast . Health longevity good healthspan is the key to living better. Get off your seat so true sitting is the new smoking 4 Reply 1 reply @patrick815 @patrick815 1 year ago (edited) So I came upon this wonderful man through Dr. Rhonda Patrick. Thank you for this incredible podcast. You have spoken about IRON, what about folks with Thalassemia? Will they live longer based on your theory? 1 Reply @roaminx @roaminx 1 year ago In extremely trying times a glimpse of an extraordinary better future. Thank you. Reply @marcoperetta5730 @marcoperetta5730 1 year ago Dr. Sinclair, What do you think about high calorie, high protein diets like the ones that are recommended for muscle building (hypertrophy) programs? For what I understand, you can't have that much calories overall in a single meal, but it's been proven to be effective on building muscle. Is it worth it to go that path if slowing down aging is your goal or it's actually not beneficial? 4 Reply @emiliov5956 @emiliov5956 1 year ago this is insane. I love this podcast Reply @qzujb @qzujb 1 year ago Hi David, in a later episode, can you talk about CRISPR Gene editing. In the potentials that this technology has to offer in the aging topic. Thanks appreciate what you doing keep it up. Remarkable work! 2 Reply @thepathofeudaimonia947 @thepathofeudaimonia947 1 year ago One of the few channels/podcasts I am eagerly waiting for the next episode! 6 Reply 1 reply @stephenlucier @stephenlucier 1 year ago Excellent episode! I can’t wait until hyperbaric chambers are commonplace. Reply @lover7235 @lover7235 1 year ago "Move your ass to live happier and healthier"🙏 Thank you for this tremendous WORK! Nowadays - scientific knowledge is a real power 1 Reply @fiaflodtrollslanda2484 @fiaflodtrollslanda2484 10 months ago Thanks fot the video! These podcasts are so great! I love the content! Reply @haileynichelle8343 @haileynichelle8343 1 year ago Thank you! Could you review various sleep devices (like Oura, Fitbit, etc.) and rank them by accuracy/comfort/value? Reply @mariamorris954 @mariamorris954 1 year ago So greatful for your work, thank you, You two 1 Reply @jimmyessien8619 @jimmyessien8619 1 year ago Excellent episode. However, I was a bit disappointed that there wasn't much talk about saunas 😅 3 Reply @danielfradkin3536 @danielfradkin3536 1 year ago Hello,You talked a lot about different stressors that can make our body to turn on defense mechanisms.What about breathing technics (Wim Hof or Buteyko for example).Can they have the same effect?Thanks Reply @carljones272 @carljones272 1 year ago Hi I do love all the information you put out. Please could you tell me how you can put on muscle mass without eating protein? I have cut down on protein intake but I am really losing my muscle mass. Reply @theonetrueshibe9567 @theonetrueshibe9567 1 year ago (edited) Quick question, do activities that activate ampk can be combined for greater effect? For example, doing steady-state or HIIT cardio during the fasting period of time-restricted eating? fasting in a cold or hot environment? or exercising in a cold or hot environment (between safe limits)? Or are they independent of one another? Thank you for sharing these important pieces of information. Reply 3 replies @parksumin9910 @parksumin9910 1 year ago (edited) Very thankful for this video from Korea. I also would like to know more on relationship between sleep and longevity through the view of Dr. Singlair ! 2 Reply @mariettaszabo @mariettaszabo 1 year ago Hi dr. Sinclair! Can you please make a video about gadgets and devices that you use and works well for measuring things? I'm sure everyone would love it as well! Thank you for your amazing job! Reply @janisgs @janisgs 1 year ago Dr. David, would it be possible to measure Biological Age from Europe? Please please make it happen. And if there is a chance for Inside tracker to provide full service for European market, would be amazing. Or any chance to cooperate with Inside tracker to open the European lab / center? 11 Reply @snowdropRivera @snowdropRivera 9 months ago Please can you do a podcast regarding auto-immune conditions e.g. Spondyloarthritis which mainly effects the spine and often manifests at a young age, it takes on average 8yrs to diagnose and is a not well known but common condition. Only NSAID's are prescribed with unpleasant side effects, there are methods and practices that only alleviate the symptoms e.g. movement, sauna, hot baths, massage, however not all methods are available to everyone. Thank you Reply @VictorAffaro @VictorAffaro 1 year ago How amazing it is to have all this info direct from the fount and for free. Thanks a lot Reply @gianiluzzara @gianiluzzara 1 year ago I started cold baths, hot and cold baths two years ago but started heart problems. 1 Reply @vitalrestandrecoveryclinic7752 @vitalrestandrecoveryclinic7752 1 year ago Wed morning is my fav time of the wk! Thank you❤ I'd love to hear re reputable supplements. Im having a very hard time finding a good source of reservatrol 2 Reply @xoxo.sylvie @xoxo.sylvie 1 year ago In case anyone is wondering: the ring he’s wearing is an Oura Ring, since he can’t endorse the product. I have one, and it’s pretty nifty! I feel a lot better about my sleep since using it. It encourages me to sleep better (to get a better sleep score) and I feel the improvement during the day. Reply @angelaelizabethmccullough921 @angelaelizabethmccullough921 1 year ago Dr David, Do you have any advise/opinion/evidence on the effect of aromatase estrogen blockers when given as a 5 year post preventative treatment after mastectomy/breast cancer? .is there any protocols to offset this deficiency in women(as read women suffer huge age acceleration due to this)? Thank you… 6 Reply @chacmool2581 @chacmool2581 7 months ago I live near the equator and the coast. This means that I face hot and humid weather everyday. I routinely take refuge at home during the hottest part of the day. What is the impact of chronic exposure to heat on longevity? Reply @faithmacwatters731 @faithmacwatters731 1 year ago I recently found you, talking to Tim Billyeu, fascinating stuff! I will be an inspired lifetime follower for sure!!!! I would like to clarify. Piriformis, is the biggest of a group of four muscles, the lateral hip rotaters. Of which only the obturator externus travels threw the hole in the pelvic bone. The other stay more superficial. Fyi... Reply @justno9342 @justno9342 1 year ago its mentioned in the video the capacity of air inhalation to grow tissues and i have intuited this. i dont even need to do physical exercise because i can do this through proper breathing technique. though what im concerned about is the right distribution of which muscle to grow. through meditation i was also able to get inside of my body and command my system to go cold or hot. yet it eventually collapsed energetically like a hologram of a building because alongside of my thermo control, i was creating fearful stories lol. i lost my grasp on reality because i didnt know it was possible to command my body. i was once able to command my system to induce peristalsis just by thought alone. i thought i was destroying my system. 1 Reply @variamakagonova3238 @variamakagonova3238 1 year ago What about the advice (which I heard on Huberman Labs) that one should be aiming for 150-180 "zone 2" minutes per week? You talked about exercise that makes you out of breath but I'm not sure whether that counts. Or should it be 150 zone 2 minutes + 75 "vigorous" minutes + weight training? I love exercise but even to me that really seems like a LOT :D Reply @nonmagicmike723 @nonmagicmike723 1 year ago I think the cold benefits will be shown to be limited. If cold really extended lifespan, we'd see those populations of centenarians emerge in cold climates; instead, they're all in warm climates (Costa Rica, Italy, etc.) Reply @Aman.Akshay.Sharma @Aman.Akshay.Sharma 1 year ago Perfect timing as I’m out walking in shorts and it’s the English winter 😂 5 Reply @Corrans @Corrans 1 year ago At the end of the previous podcast you mentioned talking about testosterone and GH and other things. You touched briefly on testosterone in this one. What about GH and also could you talk about perimenopause and female hormone decline as we age? Thanks Reply @bt9124 @bt9124 1 year ago It's great to finally have interesting things to watch and listen to. Mainstream TV and BBC radio only hits the average iq. With this, I am pressing rewind and writing things down, looking up and listening again. Thank you. 1 Reply @parsapalsami2242 @parsapalsami2242 1 year ago (edited) At what time at daily routine should one do heavy exercise? While doing intermitten fasting, skipping breakfast and lunch. Should i do it in the morning shortly after waking up or should i wait until its evening and when i start eating? What is the optimum here? Reply @mefarrehal-harbi489 @mefarrehal-harbi489 1 year ago Thank you so much, this is a lifesaver . 1 Reply @allisonblaustein7898 @allisonblaustein7898 8 months ago (edited) 1. Exercise- whatever movement you love. Minimum 15 of aerobic per day. Add weights , Pilates or other strengthening including thighs , butt & back . 2.Hyperbaric oxygen chamber ( note: he sites studies showing lengthened telomeres. I happen to know that mindfulness including mindful yoga also lengthens telomeres - I have you tube talk about study ) 3.Cold Therapy 4. Heat Therapy including sauna 5. Minimum Once a week / 5 cycles: sauna to cold shower or ice bath. Or hot shower to cold. Even let house get hot and then cold. If doctor approves. Will feel endorphins after each stressor if doing it right. Reply 1 reply @spirulinagreen1862 @spirulinagreen1862 1 year ago Pertaining to the perniciousness of Iron, I developed Pica at the age of 13, which persisted well up until I was about 25. My form of Pica was eating sponge. And after looking for answers for years, I read somewhere, excluding the possible pyscholigical reasons, that Pica especially the eating sponge bit was because of lack of iron. And started supplementing with iron and miracle of miracle my pica was gone! And I notice that's the only way to keep the pica completely abay. But I am rather confused about what approach I could take now? 4 Reply 1 reply @norintellconsultancy9414 @norintellconsultancy9414 1 year ago In this podcast Dr Sinclair reveals a condition he suffered from standing while writing the Book. What Dr David Sinclair has revealed is, according to TCM a precursor of similar or even worse to recur when the body is declining. Let's KIV especially when he reaches 75 y-o onward. The last guy who heard alot about what Dr Sinclair is advocating was Dr Deepak. Reply @reneduval1937 @reneduval1937 1 year ago Did I understand right: injection with NAD in the piriformis. Is it a kind of regenerative tech? If yes do you know the protocol? Thanks you for this great podcast😊 Reply @pubz2149 @pubz2149 1 year ago I have been following Dr. Sinclair since I was 25. I am 22 now. Reply @alialnajjar9583 @alialnajjar9583 1 year ago (edited) You are a super knowledgeable guy. Thank you so much for the knowledge and inspiration you are spreading. However, YouTube is already full of advertising. Please try to find another funding model so we keep trusting you. Reply @valeriehopebennett @valeriehopebennett 1 year ago thanks for this great information we all need this i deeply appreciate and i am most grateful for your success. Reply @kasiag5272 @kasiag5272 1 year ago Question, do these things change (eating less, taking cold showers etc etc...) if you live somewhere that is already damp and cold? 3 Reply @QuyenAhri @QuyenAhri 6 months ago I have read that heat can damage your skin even before you notice any discoloration. Exposure to heat can destroy collagen and elastin fibers in the dermis, eventually causing it to become thinner and weaker, leading to premature wrinkling. So sauna is very high heat, isn’t it bad for cosmetic aging? I have been wondering about this for years, I appreciate if anyone can provide answer to this. Reply @robjvmedia260 @robjvmedia260 1 year ago I've gotten great results from using the Hyperbolic Time Chamber. Spent about 10 Earth-years there; came back super pissed and ready to rock. Resting HR: 1 bpm, Glu: 0, Oxy: all of it. Reply @themcdowells23 @themcdowells23 1 month ago late to the party but never the health. Thank you gentlemen :) Reply @veryhappy6003 @veryhappy6003 8 months ago I just read an article that also says high levels of iron are not good but mentions that iron and copper are highly interdependent and need to be considered together. Low ferritin is rarely indicative of low iron. In most cases, it's a sign that copper insufficiency is preventing proper iron recycling. Reply @rexdv8 @rexdv8 1 year ago (edited) I wish that I could have had access to a hyperbaric chamber two years ago when I woke up with sudden sensorineural hearing loss in my right ear. It's not the hearing loss (a big portion of it, at least) that bothers me; it's the 24/7 high-pitch tinnitus that I have to endure. My ENT tried corticosteroids directly and by mouth for the hearing loss, but to no avail. He told me a hyperbaric chamber a few times a week might repair the damage, but I had no health insurance at the time. Now that I do have health insurance, I wonder it it's too late to repair the damage. Probably is. I'm 52 now, and I don't know that I can deal with the tinnitus for another 10, 20 or more years. Reply @CriticalMassAwakening @CriticalMassAwakening 1 year ago (edited) Ooof, I lost over half my hair 3 months after having Delta. It’s finally starting to grow back but I lost so much. So overwhelming. They are calling 2021 The Year Americas Hair Fell Out. Maybe do a cast on the Covid hair loss? There’s a yoububer who is losing hair 17 months after just losing her smell and taste a few days. It’s insane. Feels like radiation sickness. My Thyroid test came back normal but I am always iron and D deficient no matter what I do it seems. There are articles all over the internet about Covid hair loss. I’m not on Fb but a lot of my friends and family are coming to me telling me more and more they are seeing people sharing about their Covid hair loss experience. It’s becoming a sort of an epidemic of its own. 😣 not fun at all. I went from my hair very thick and long to filling the toilet every day for almost two months. I’ve heard of plumbers posting about pulling wads of hair out of the septic lines from Covid hair loss. It’s no joke. Bless. 3 Reply @richardanderssen @richardanderssen 1 year ago (edited) Extremely informative and very actionable ⭐⭐⭐⭐⭐ 2 Reply @kostas.dino31 @kostas.dino31 1 year ago In a future episode, please can you talk about peptides like epitalon that have been shown to lengthen tolemeres? Thanks alot! 1 Reply @hannabakhash806 @hannabakhash806 1 year ago Loving the podcast. Please consider adding visuals every now and then for better demonstration ❤️❤️❤️ 2 Reply @sam-in7ll @sam-in7ll 2 months ago I'm a bit confused here Doc. Pretty sure in the previous episode you said excess protein is not good. I was a bit gutted coz I enjoy resistance training (calesthenics + weights) and because of this maintain a high protein intake as part of my goals (previously building muscle now losing fat). This episode you said weight training is beneficial but then how does that fit in with the required protein intake to build muscle and/ or strength? Feels like we have to look at the overall picture of our health and trade off what is beneficial to us and what we enjoy/ what our preferences are. If you could clarify this further please that would be super helpful. Thanks Sam Reply @JohnLentSelflessHero @JohnLentSelflessHero 1 year ago (edited) Separate question - the benefits of cold immersion seem to come from a chemical released during the shiver response called Succinate. Is this being looked at in terms of mechanism for aging? Is that the same chemically (or would you get the same effect from) Disodium succinate (C4H4Na2O4·nH2O)? I have a very hard time inducing shivering even in very cold temperatures, so a chemical short cut would be amazing. It seems to induce hypoxia, which is what you say the pathway of intense exercise does. Reply @NoraEleanoragg @NoraEleanoragg 1 year ago Could you please, please, please do one episode talking about everything - supplements, fasting, cold and heat exposure and anything relevant for optimal health and longevity for women? As you have mentioned before there are differences and when you talk about these things and especially doses of supplements I think its for men. Pleaaaaaaase do one episode for women 🙏 397 Reply 30 replies @NancyBaumgartenButler @NancyBaumgartenButler 1 year ago Dr. Sinclair, I am so curious about how people in their 70s who feel and look much younger can use your programs or what should we do differently than someone in their 40s and 50s? I’ve asked several times how do you feel about eating honey? 2 Reply @risahardin7993 @risahardin7993 2 months ago So many thought provoking tidbits but the hyperbaric chamber information...I've been screaming how beneficial it has to be for more than just wound therapy. Tried to get Medicare to pay for treating both my parents with it after strokes which seemed to be a no brainer but wasn't covered and I didn't have the funds at the time to cover it myself. Bringing hope to so many with all of this thought provoking data:) Thank you both. Reply @Mherder89 @Mherder89 1 year ago Question on hyperbaric oxygen treatment: Has anyone looked at nitrox scuba divers? Since most divers log their dives (depth, nitrox and duration) this should be really nice data. Reply @theleechqueen @theleechqueen 1 year ago Aww my resting heart rate is 52bpm at 32 yo. For David to be around 45bpm, that's pretty impressive. Reply @jennym4127 @jennym4127 1 year ago Very Interesting! It would be helpful to know if the cold/heat therapy adds to the benefits of the diet/exercise programs or simply duplicates them? In other words at what point has an individual maximized the benefits? Also it’s a bit disheartening to see the super agers close to, or even over a century, and LOOKING it! Why would the biological systems maintain longevity and supposedly, health, and the skin just continue to age relentlessly?! I’ve never seen a centenarian without the extremely mottled skin, huge discolorations, red and sunken eyes, not to mention a network of wrinkles and sags. So. Is anyone working on skin aging? 1 Reply @juleslloyd9162 @juleslloyd9162 1 year ago I’d be interested to know if there are benefits to starting this at a younger age say before 30 or if you still get the same benefits starting after 30? 6 Reply 3 replies @cs5995 @cs5995 1 year ago first podcast , speaking of get off your butt, your so right! im a massage therapist so I know plus Im writing alot and i have a partial frozen shoulder and a pain in my ass from sitting..🤣 Im currently fixing all the damage ive done.and I know better. 1 Reply @floricadunca6909 @floricadunca6909 1 year ago Thank you so very much dr Sinclair,have seen you in Lewis H podcast.I am a new subscriber,very appreciate your work . 1 Reply @guidok3762 @guidok3762 1 year ago Great video (again), share this video as much as you can with all your friends 1 Reply @deregudeta6187 @deregudeta6187 1 year ago Humble person full of wisdom Reply @karencote1945 @karencote1945 1 year ago What temperature should the house be turned down to, for how many minutes, and how often a week to get results? Are the results from living in a cold home as good as other cold therapy methods? Reply @Martin-ec9mh @Martin-ec9mh 1 year ago How much iron is too much? What is the maximum level for Hemoglobin [g/dl] and Ferritin [ng/ml]? Which values are optimal (for an adult)? 3 Reply @jawadkarim6615 @jawadkarim6615 1 year ago (edited) Professor David Sinclair, I just salute you from my Heart..... 1 Reply @TheZizzac @TheZizzac 1 year ago David mentioned very briefly in a sort of off hand comment that a scientist had healed part of the brain (thalamus?) using a certain protocol that used HGH. I can't find it now and I would really like to explore this topic. Does anyone know the timestamp and correct episode? Reply @peterz53 @peterz53 1 year ago Thanks! Question: what form of iron? Ferritin? Optimum range? This is rarely measured and is not on basic CBC panel as plasma iron is. 2 Reply @jenniferfink1728 @jenniferfink1728 1 year ago Question about mtor and weight training. You recommend weight training so that you can maintain muscle mass as you get older. But you also recommend reducing protein intake because of its effect on mtor. But don't you need a good amount of protein to build and even just maintain muscle as we get older? Thanks! Reply @potentnaturals188 @potentnaturals188 1 year ago (edited) What’s the best way to do hot/cold shower? I tried this but i burned my body skin and suffered itchy flaky peeling skin for more than 2 weeks. How hot is hot and how long we alternate the hot and cold water? Reply @eyeandmind @eyeandmind 1 year ago Folks, get ready. David is soon becoming a rock star! Thanks for sharing your expertise! 5 Reply 2 replies @SuncloudMashups @SuncloudMashups 1 year ago You mentioned the general trend of getting a high after performing various adversity mimetics. It made me think of yoga practices that result in a high, I'm assuming in part by stimulating the nervous system and oxygenating the body. Anecdotally, after performing certain asanas for many minutes (which is a bit uncomfortable) I'm typically put in a state of incredible well-being accompanied by a natural slow deep breathing despite feeling my heart rate elevated from the exercise. It's always felt like an incredibly healing state and I'm wondering if yoga (in particular Kundalini yoga practices or any practice that involves repeating short movements with specific breathing for 5+ minutes at a time) is being studied in relation to longevity? 1 Reply @raiderlife4478 @raiderlife4478 1 year ago A question about the HBOT? could one achieve the same thing with sicklic hyperventilating? Or like you said using pure o2. I'm a welder and I don't know how pure our oxygen is in the bottles we use. However could I just breath that in and achieve this hyper oxygenized state ? 1 Reply @joy-cl1ms @joy-cl1ms 1 year ago Thank you both!💞 1 Reply @szymondrabek7664 @szymondrabek7664 1 year ago Dr. Sinclair, regarding the previous episode - is it possible that even a small amount of calories would trigger a break of 16 hours fast? I have no issues drinking tea/water from 8 am till 1 pm (first meal) but when i add a bit of milk to the tea then im really struggling, shaking hands, growling stomach etc. Any advice? 1 Reply 2 replies @arthurthegreat216 @arthurthegreat216 4 months ago On the podcast with Andrew Huberman, you said that growth hormone actually ages the body. In this podcast you say that saunas are great for longevity. Now, it is also been found that sauna increases the body's growth hormone production by many folds. How are these two facts reconciled? Do saunas accelerate certain aspects of aging while slowing down other aspects of aging? Reply @JudytaNala @JudytaNala 1 year ago Started with cold water at the end of the shower... will get there, comfort is such a trap! 5 Reply @attractionnow @attractionnow 10 months ago Hey guys from April 2022 to August 2022 my triglycerides went from 100 to 50 ,I believe it was partly due to me working in a walk in cold storage warehouse. I also spent 2 to 4 days a week in sauna. My asian endocrinologist applauded me 3 times for achievements on my blood work. Get cryotherapy and go to sauna .PERIOD. also heal your gut Reply @Sykara @Sykara 1 year ago That moment between them at 44:11 really got me Reply @gabrielamadorno4926 @gabrielamadorno4926 1 year ago I have been supplementing with zinc forever. After listening to you I will stop, but how can I get rid of the excess zinc in my body? 2 Reply @carpediemjonah8110 @carpediemjonah8110 1 year ago Can you post the clinical study which justifies the infra red sauna studies? The manufacturer claims are all over the map. If possible I would like to know which type, [or brand] ,of infra sauna red was used in the better studies. Absolutely love your knowledge and your wisdom 1 Reply @surfpipeline @surfpipeline 1 year ago Incredible - keep going!! Reply @Klaude @Klaude 1 year ago Reminds me of Huberman Lab. Another great channel! Thanks! 3 David Sinclair Reply @melhouri @melhouri 1 year ago Love you guys. Keep roving it! 1 Reply @Kitehomiez @Kitehomiez 1 year ago (edited) What dietary/lifestyle interventions are there to maintain healthy lower iron levels? I didn't see a clear idea other then no multivitamin/less meat. Also have you looked into wim hof method breathing for mimicking hypoxia and cold exposures? Reply @agustinperalta1872 @agustinperalta1872 4 months ago Great episode! How to get lower levels if hemoglobin if I live high in the mountains? Reply @MrLJeffery @MrLJeffery 1 year ago Epic! Thanks for your work :) 1 Reply @waterjar27 @waterjar27 1 year ago I’d love to see some good information about supplements based on body size. If the label says one dose is two capsules, if you weigh 100 pounds, should you take one? There are people on both ends of the size bell curve who could benefit from better information. Reply @w.w.w.w.w @w.w.w.w.w 1 year ago Hi Dr, love your podcast so much, I'm starting fasting, just wonder if taking Athletic Green daily in the morning as recommended hours before my meal will impact fasting? Or better take after a meal? Thanks! 4 Reply 4 replies @Gt99094 @Gt99094 1 year ago Please discuss the effects of cortisol relative to the anti aging regimen of creating low level stress. 1 Reply @mcbryant2 @mcbryant2 1 year ago Would love to see some studies comparing Wim Hof breathing to hyperbaric treatment. Reply @ericoshea9382 @ericoshea9382 1 year ago Super informative! Reply @sirravi @sirravi 1 year ago Thanks for the actionable tips 👍 1 Reply @lelle9901 @lelle9901 1 year ago So, what is a "little bit" and what is "too much" stress created by exercise? I wish Dr. Sinclair had been more specific about that. I work out about 4 hours a day: three times a week heavy weightlifting for 45min, twice a week gyrotonic (moderate intensity light weight exercise designed for dancers) and three times a week gyrokinesis (light exercise), I ballroom dance 2-3 hours daily (moderate intensity with periods of high intensity and some light intensity) and I also stretch another hour, which is low intensity except on my Ashtanga yoga day which is more low-medium. Plus, I run once a week for 20 min (tempo run) which is high intensity. That's nothing compared to an elite athlete (my daughter swims four hours a day medium/intensity, for example), but it is hardly 10 minutes three times a week. It would be nice to know what all that does to my mitochondria :). 1 Reply @jules153 @jules153 1 year ago Does "cold" have to be actually cold or just relative? For example if you live in the Middle East with no air conditioning even a 20degC bath would seem very cold, where as a resident of Alaska would thing the same 20degC bath to be quite warm I'd think..... 3 Reply @Marky001100 @Marky001100 1 year ago As an ex-commercial diver I've noticed some time ago that a lot of divers look quite younger than their age. Well, lets say disproportionally so if we are to compare with general population. I guess that explains it. Being underwater with a scuba tank is the same as chamber it terms of pressure. We also use Nitrox at times, which is air with increased Oxygen %. It would be awesome to hear if Dr. Sinclair has seen any research on divers in that context. I mean scuba diving might just be that cheaper alternative for hyperbaric chamber treatment... I don't really see it being any different in terms of physics of the two. Reply @ka-ba-ahk @ka-ba-ahk 10 months ago Is there a way to have a test to tell you your ideal diet based off of your DNA as well as what nutrients should consume based off of poor absorption ? Would love to purchase such test if it exist Reply @ci4396 @ci4396 1 year ago (edited) ive dont like 40 sessions of HBAT and they recommend you to stay awake because the breathing gets more flat when you fall asleep and you should try to take deep breaths while youre on there. each session is about 90 minutes and you cant bring anything inside with you. i always did it in a chamber with room for 6 people and they had tv"s mounted to the tiny windows and speakers inside so we could watch movies. most people there did it for hearing problem, i was just there to try and fight my chronic diseases. edit: oh yeah, it didnt help at all. well in the beginning i felt like it helped me with my sleeping disorders. i felt like my quality of sleep was better or at least i felt more energized during the day, but after i had to take a week off, my sleep got worse again and i did another 20 sessions and never got better again 1 Reply @rupenpatel1313 @rupenpatel1313 1 year ago I noticed Keto gives me a lot more motivation to get up and do things. It's like your body/brain is saying get up and get stuff done to survive. Diet of carbs, feeling is lethargy. Don't worry. Pop to the grocery store if you need more. Reply @LaJewel @LaJewel 7 months ago What about anemia caused by gluten sensitivity? My gluten sensitivity made me so anemic, I had under 7 pints of blood (I should have 10) and needed 2 pints of blood at Dx. With a gluten-free (and low lactose & low fructose diet), plus an iron supplement, my iron levels normalized, but I need to exercise to build muscle to store iron. Where would soem liek me fall? I look pretty young for my age, though I do work on my blood pressure to keep it down.) Reply @MatoMkenya @MatoMkenya 1 year ago There is constant mention of eating less. What if you are thin from the start don't restricted feeding serve one better? Then again do you avoid foods like rice, flour and the likes of foods with high glycemic index? 4 Reply @luisoyarzun6986 @luisoyarzun6986 5 months ago Muy buen video. Gracias. Reply @karendagrava544 @karendagrava544 1 year ago How soon would you say the toxins should be showered off after the sauna? I hate showering at the gym and so I’m cooled down and dry by the time I take my shower at home. Have I already reabsorbed the toxins? 1 Reply @shobanbabukommusportsphysi3793 @shobanbabukommusportsphysi3793 1 year ago This is awesome inforfamtion Sir. Thank you very much. 1 Reply @laylayang7374 @laylayang7374 1 year ago Your guys are amazing ! Love you ! 1 Reply @gloriagiorgi1026 @gloriagiorgi1026 1 year ago (edited) I believe I have Raynaud phenomenon if I’m exposed to harsh cold, even if that was never diagnosed. So would cryotherapy be dangerous in this case? On the other hand I have spider veins (I know it’s only an aesthetic problem) but should sauna also be avoided in this case? I’d like to know if I can try either one or the other safely. Also, when you mention the benefits of infrared therapy related to skin aging, can that improve sun damaged skin as well? Thank you. Reply @pallaviverma5541 @pallaviverma5541 1 year ago Thank you so much 👍🏻❤️ 3 Reply @Rocky-op3xh @Rocky-op3xh 10 months ago If you have sleep apnea and have periods of low oxygen at night, would that trigger a stress response and have a positive effect? Reply @delaneyondreams @delaneyondreams 1 year ago In about 2016, when I first learned about sitting be as harmful to us as smoking, I cringed at the idea of standing desks! But then I found a lectern upon which I rigged my writing surface and behind it a tripod with a flat top that held my computer so I could experiment with conducting my 3-hour workshops training professionals in the Dream Interview Method of dream interpretation. I did these at all hours, for groups gathered in one room in Europe, Australia, and so on in mornings and evenings. To my great and happy surprise, I was even more energetic and thrilled by my students than after my seated private and group sessions. The sessions flew by, and I looked forward to them almost as a more lively adventure. I have rarely been seated for any of my dreamwork since. My next resistance: Cold shock. I weigh 92 lbs, and chill as easily as a tiny dog. I am hoping that 60 years of competitive and recreational ice skating in very cold rinks, might excuse me fron that torture. Thanks to Dr. Rhonda Patrick I have taken up saunas again and hope this delightful habit and the infrared waves of our sauna will bring some of the painless benefits that Dr. Seheult so excitingly describes in his new video on MedCram 12 days ago, "Sunlight: Optimize Health and Immunity (Light Therapy...). I do hope Dr. Sinclair will comment upon this work! If any of you are around my weight, and have found a way to get over avoidence of cold water, please let me know. Reply @rudeboyjim2684 @rudeboyjim2684 8 months ago “The mice were shivering” “And to be clear, they weren’t shivering because the lab was cold, they were shivering because…” “Because mice are social, they want to be around other mice” “So we gave them a friend, and the longevity went away” “Because…?” “Because they weren’t cold anymore”. This may be the most confusing and internally contradictory anecdote I have ever heard. Reply @marilynnfreeman459 @marilynnfreeman459 1 year ago If it is in your area of expertise, would you please address the positive effects/research, etc. Of red light therapy? thanks! Reply @vsecarin @vsecarin 11 months ago Does anyone know whether there is any chance that a home use oxygen concentrator might have some of the effect of a hyperbaric session? Reply @alexanderboyd7925 @alexanderboyd7925 1 year ago If high iron levels in the body is associated with early death, then would giving blood 1/2/3 times a year be beneficial to longevity?? 4 Reply 4 replies @premp7907 @premp7907 1 year ago If adversity results in longevity, can a short term disease (such as covid) also result in longevity? 1 Reply @bball0928 @bball0928 1 year ago Thank you for the amazing insight David. Would you be willing to comment on Turkesterone as a supplement for muscle growth? I am curious if this supplement has a positive or negative effect on longevity. Ajuga Turkesterone Extract 500mg (standardized to 10% Turkesterone). Hydroxypropyl-Beta-Cyclodextrine complex. 1 Reply @billy4525 @billy4525 9 months ago Amazing information, I will follow for more Reply @williamvalle2965 @williamvalle2965 1 year ago Does athletic greens break your fast if taken in the morning when you are on a 16:8 intermittent fasting effectively skipping breakfast? And if it doesn't is it okay if taken on an empty stomach? 1 Reply @roigottlieb498 @roigottlieb498 1 year ago Hi , first I want to thank you for great content. 👍🏻 I want to ask if there is not contradiction between you said that you skip breakfast and lunch and that you take athletic green every morning? Something else don’ t you think that after exercise you need to eat? Or you recommend for someone who do it in the morning need to wait for dinner? One more thing if I start the morning with an apple and skip breakfast and lunch is it ok? Thanks Reply @the_future_is_anarchy1791 @the_future_is_anarchy1791 1 year ago (edited) I really want to know what your thoughts are on ghrelin suppressants would you recommend people take them? 3 Reply @ginavanulzen6681 @ginavanulzen6681 1 year ago I’d be curious to know if all these changes impact physical appearance, will collagen be made better with preserved genome? Will fat stay in the face and not go to the abdomen? If you use sunblock and have take all their advice I wonder how much younger your skin would look….. 1 Reply @lancecarter6837 @lancecarter6837 1 year ago Regarding hypoxia and it's benefits. What about creating it via breathwork? IE: Like what Wim Hoff does with over-breathing followed by breath holds. Could you comment on that as an option? Reply @CosmicSphinx @CosmicSphinx 1 year ago As someone who lives in Eugene Oregon, I laughed out loud, hard on your comment about free radicals! 😂 Reply @jburton1419 @jburton1419 1 year ago If hypoxia can be good for you how does that explain sleep apena being unhealthy? Also how do you handle intake of Metformin if you exercise and weight train as often as you do? Reply @konchokgyatso9193 @konchokgyatso9193 1 year ago I can't wait for next #4 podcast.. 1 Reply @sarrormiki3363 @sarrormiki3363 1 year ago (edited) Fun fact: Finland has more saunas than cars Edit: Saunas are really deeply baked into our culture. They're usually between 70 - 80 briefly even 90 and 100 celsius (for the crazy people, which is when water starts boiling). "Fun" story: There once was a official sauna contest, you know who can survive the longest in the sauna. A russian and a finnish dude went head to head in the finals. I don't remember for how long they were in there but the sauna was at 120 degrees and the russian dude died while the finnish guy became paralyzed. He had to learn to walk again etc. So you can definitely over do it with the time and the temperature :D stay hydrated while in and out of sauna and just listen to your body and you're fine. Also don't fall asleep in there and don't have stupid macho contests. Reply @MyRachelh @MyRachelh 1 year ago I’d love to know what the data says on ‘cheat days’ or once off high calorie/junk food intake 😀 Reply @user-tx2tn3sc7i @user-tx2tn3sc7i 1 month ago You talk about HBOT therapy which is very effective but what are your thoughts on EWOT hiit exercise while breathing 93% oxygen, do you think this has merit? Please don’t stop making the podcast! Thanks Reply @ryanweller1163 @ryanweller1163 1 year ago Id like to see a study done in people exercising in a hyperbaric chamber Reply @MinMin-kv3rv @MinMin-kv3rv 1 year ago everyone says cold treatment is really good, but I cannot force myself to any cold experience. It's associated to bad survival trauma or something. Any suggestion how to mimic cold benefits? Reply @brandi1221 @brandi1221 7 months ago I jog about 5-6 times a week but am able to maintain a conversation. Do I need to be pushing myself harder than this for the health benefits mentioned about making yourself breathless? Reply @jessmansportscards @jessmansportscards 1 year ago Thanks. The time stamps help a lot! Reply @ninjashhh8344 @ninjashhh8344 1 year ago Thanks for all you share 🙏 Reply @isaacepstein8971 @isaacepstein8971 1 year ago i like to soak my feet in a temp regulated foot bath at high temp for a long time (45 celcius for 30~40 min). is there any research on that? i end up sweating like crazy. i do this whenever i feel a cold coming on. stops it in its tracks Reply @nebiyatnigusiewoldeyohanni4051 @nebiyatnigusiewoldeyohanni4051 1 year ago Dear David and Mthew thank you are very helpful Reply @patriciacell3303 @patriciacell3303 1 year ago Love it, thanks so much Reply @johnnyroberts5994 @johnnyroberts5994 1 year ago Hey doc , can’t you super oxygenate your blood with breathing methods , like used in Wim Hoff and others ? Seems like the results may be similar 🤷🏻‍♂️ 2 Reply @peterz53 @peterz53 1 year ago Cold: Prof Vera Gorbunova has shown new data in her ARDD2021 presentation that life extension in Bowhead whales (over 200 years) appears due to upregulation of CIRPB which improves double strand DNA repair. She is testing exposure to cold exposure in lab animals. 1 Reply @ryanhouston1275 @ryanhouston1275 1 year ago ive seen a lot of debate on the topic of whether or not something like black coffee breaks your fast. david sinclair, or anyone in the comments who has heard his opinion on the matter, will things such as black coffee hurt your fast? thanks! 1 Reply @antoniodossantos5960 @antoniodossantos5960 1 year ago Deep, very interesting information 🌎 Thanks. Reply @kirubelterefe9070 @kirubelterefe9070 1 month ago How does our blood glucose level work when we in a fastened state and we feel hungry? What is that hunger feeling? Because in other situations if we had to eat a high carb meal about 2hrs later we’ll get that glucose spike and be hungry again, but what does it mean if we’ve been in a fastened state? Reply @HangingwithVinceandTina @HangingwithVinceandTina 1 year ago Is being on TRT bad for you, if so how can you come off without returning to the symptoms that you had before the TRT? Reply @brittamontes5663 @brittamontes5663 1 year ago Perhaps someone can help me answer this question - Are the benefits of sauna bathing and hot tub immersion similar? (A lot more people I know have hot tubs. I suppose it depends on where you live.) Reply @opheliaelesse6626 @opheliaelesse6626 1 year ago i once was forced in january, 0 degrees celsius, to jump into a rotten old pond, 1.50m deep, to save my old blind little dog from drowning. i was fully in winter clothes. hopefully i stimulated an extra year with this. ;-) don't torture the little mice fellows, the basics of this knowledge is available without their suffering: eat healthy, less, move, sleep, have friends. greetings from germany Reply @jaimel2037 @jaimel2037 1 year ago I live in Ireland at the moment and now in middle of winter just going for an hour walk at 6am or evening is plenty cold therapy!😅 1 Reply @alejandraalvarezdetoledo1783 @alejandraalvarezdetoledo1783 1 year ago (edited) David would you say that hyperoxia would be similar to the Kundalini breath? i have done that foe many years and i think it had really helped my whole body. Reply @KAI5ERCHIEF @KAI5ERCHIEF 1 year ago is it ok if we do the cold therapy the same day after the workout? 1 Reply @LABETONETA @LABETONETA 1 year ago this is so truth, love it Reply @jj900 @jj900 1 year ago Could you cover breathing - wim hof breathing, nasal breathing at rest, nasal breathing durin exercise (that one i dont get). In terms of the hyperbaric oxygen part, the cyclical too much o2/hypoxia sounds similar to the cyclical breathing in WHM. Looks like po2 levels went up om their abgs, and sats/po2 went down during the breath holding phase. Reply @cassandrabrecht @cassandrabrecht 1 year ago So excited about this! Reply @bifftannen324 @bifftannen324 1 year ago G'day Dave! Anxiously awaiting breakthroughs in glaucoma treatment, mate! Full speed ahead ay? Reply @novicerider751 @novicerider751 1 year ago How would you maintain adequate muscle mass through fasting and having a more plant based diet? It seems like building muscle counters the down regulation of mTOR receptors by requiring an INCREASED intake of branched amino acids. Reply @JM-te2jn @JM-te2jn 1 year ago Any research that shows a dehydration stress works similar? No way our ancestors were drinking 8 glasses of water a day, we got lazy there too. (Endospores on a microbe level live forever) Further thought would be an adrenaline spike could also add to longevity. Reply @kay9man159 @kay9man159 1 year ago You have explained the iron issue and emphasized the ferrous iron. Red meat offers heme iron. Heme iron is ionic and is used properly in the blood. Do we not have a true look into the difference with aging in the type of iron found in prevalence? 1 Reply @larssorenson9916 @larssorenson9916 1 year ago Muscle atrophy with aging - Dr. David should do a deep dive on KAATSU cycle blood flow restriction. My guess is that he would be impressed. Reply 1 reply @edwardnino9896 @edwardnino9896 1 year ago Thank you both for the excellent podcast!! Dr. Sinclair is brilliant but thankfully understandable, and Mr. LaPlante is the perfect interviewer to ask the questions we would like to ask, Greatness incarnate!! 2 Reply @PamelaPickles02 @PamelaPickles02 11 months ago Question about cold therapy...I work in a refrigerated room, I believe 42 degrees F, while wearing a thermal shirt, a polo shirt, jeans and sneakers. I also have access to a walk in freezer, is that too cold? If not, how long can I stay in the freezer wearing the above mentioned clothing? ( I can't remove my clothes...I'd lose my job!) Reply @chacmool2581 @chacmool2581 7 months ago If too much iron is deleterious, how does that impact the longevity of highland populations that have adapted and carry more hemoglobin in their blood to make up the thin air at altitude? Reply @RezaSMahani @RezaSMahani 1 year ago The discussion of "Hyperbaric Oxygen Therapy (HBOT)" (00:49:47) reminded me of the Wim Hoff Method (hyperventilation+breath hold) which increases blood oxygen levels and then CO2 level alternatively. I wonder if that has similar health impacts?!? Reply @JenP2776 @JenP2776 6 months ago There are several meditative breathing techniques (pranayamas) that can stimulate mild hyperoxia without the need for a hyperbaric chamber. I would imagine that one could also use the small cans of O2 that people at high altitudes use?? Reply @annamilrud9910 @annamilrud9910 8 months ago Great episode! Thanks. But what about breathing machine for Sleep Apnea? Does it do a job? Reply @MSteitz468ify @MSteitz468ify 1 year ago Great way to get rid of iron is donating blood once a month, and you're helping others. 1 Reply @mayrakennedy6200 @mayrakennedy6200 1 year ago What are your thoughts about electric muscle stimulation training? I've been training with a product called Xbdoy, ems suit that stimulates muscle contractions. would this style/type of training help with aging? Reply @j4s0nm1cha3l @j4s0nm1cha3l 1 year ago Great Podcast Guys. You mention About Hyper Baric Oxygen Therapy (HBOT) What's the science or your opinion about Exercise With Oxygen Therapy (EWOT)? And what's your tought about using Oxygen while doing IF Sauna? Thank you. Reply @jwalther6045 @jwalther6045 1 year ago Please guide us to a resource that evaluates supplements. Thank you for all your work. Just finding this and I’m 65. Yahoo! Reply @marcoelia4401 @marcoelia4401 1 year ago What's the record in longevity in regular mice treated with anti aging protocol? (Not dwarf mice) Reply @carolinalucin8073 @carolinalucin8073 11 months ago I’d like to ask about your thoughts on crosssfit-hiit workouts, do you think training CrossFit 5 days a week can help or affect negatively? Thank you so much!! Reply @oliviapos3397 @oliviapos3397 1 year ago Sinclair is only a few years younger than my parents and his skin has no signs of ageing in any photos and arguably looks younger than some photos on the internet from the past !?!? 2 Reply @dwingo8003 @dwingo8003 1 year ago (edited) 90 minutes 5 days a week in a hyperbaric chamber are really going to be difficult for the average person to do ...not realistic. However with that being said , great information . Thanks Reply @camiloelchilo4658 @camiloelchilo4658 1 year ago What about fasting and intense exercising, should I keep my 22/2 protocol? Is it healthy? Thanks Reply @nielssolar @nielssolar 1 year ago I am interested in eating, then vigorous exercise, to reduce my blood glucose and having that start my intermittent fast. Does that in a sense extend the value of the fast? Reply @kennethrichards3143 @kennethrichards3143 9 months ago I noticed if you get into a really cold pool especially when I was young for a long period of time when you get out you feel injuvenated and just better have you noticed that David Reply @inescastaneda1790 @inescastaneda1790 1 year ago So with fasting and skipping breakfast and maybe lunch, how do you fit in the athletic greens plus the yogurt which you take with the supplements. Does this not break your fast? Thank you Reply @williamwightman8409 @williamwightman8409 1 year ago Why would it be better to spread exercise out over the week? Hormesis would suggest that an endurance and hypoxic combined related stressor done vigorously say twice a week would be more effective, as long as you are not structurally failing body parts. You should be tired the next day, even if you had a good night sleep. On the second or third day of rest you should feel 110% and ready to go again. Reply @MrEvilsparrow @MrEvilsparrow 1 year ago (edited) I'll burn ten. Not that funny, but in this setting, and out of nowhere, this cracked me the hell up. Hats off, sir! Reply @brankitos @brankitos 1 year ago I’d really really really like and appreciate answer on my question…. How can I control my anger and bad breath while being on 24h fasting? Is it ok if I am every day on 24h fast? I am a 29y old woman planning to have children in next 1-2 years. 1 Reply 1 reply @Gman-nb9ge @Gman-nb9ge 1 year ago Great for the work commute thanks 😊 Reply @manjuri9985 @manjuri9985 1 year ago I am runner though beginner. I run early in morning as that’s the time I have and we have a team which operates at that time of the day. I am trying to do intermittent fasting but I am confused about it as i am worried about my performance. Please guide . Reply @tumangeorange8388 @tumangeorange8388 1 year ago QUESTION: If I take Athletic Green empty stomach in the morning does it count a meal?? btw, I am doing 20 and 4 diet Reply @CUCHIFREN @CUCHIFREN 1 year ago Thank you Dr Sinclair Reply @bendikkirkbakk1833 @bendikkirkbakk1833 1 year ago love it.begin the day with sauna/ice shower each day Reply @videos25755 @videos25755 1 year ago For the heat therapy I think sustained heat for a longer period at lower temperature may also have benefits similar to a sauna. I do hot yoga at 40 degrees Celsius minimum for 90 minutes at least once a week. One thing also to note for heat is the psychological benefits for certain people. It has been clinically shown to aid depression symptoms so it's a very positive coping mechanism psychologically as well and this has been shown for sauna and hot yoga. When I was in university the wisest professor in the neuroscience department said that diet and exercise was the cure for most mild to moderate depression and while that still may be true I would argue now that heat may give even more rapid effects due to the ease of heat therapy where available. 1 Reply @seanhakim203 @seanhakim203 1 year ago Hi David, Any dietary advice for having haemochromatosis. I have it genetically and have never had any advice from anyone Reply @jespertveit1683 @jespertveit1683 1 year ago So, since the short periods of hypoxia induced by exercise is beneficial. What about just holding your breath? Any research or theories about that? Reply @dannyrod1980 @dannyrod1980 1 year ago Cold Therapy segment: Do people that live in cold climates live longer than those in hot zones? Reply @connor6309 @connor6309 1 year ago (edited) VCID researcher here. Can confirm that current literature has linked having too much iron to an exacerbated risk of dementia. Conversely,, anemia also activates genes associated with endophenotypical models of both VCID and Alzheimer's Disease. As such, it is possible to remain healthy with iron levels on the low side, but they still need to be in an optimal range to mitigate pathogenic risk for degenerative disorders, MCI, etc. Reply @vesnasomero2975 @vesnasomero2975 1 year ago (edited) About sitting, I suppose Sadhguru would say that even sitting you need to know how... And I don't mean only mechanically 😉 Reply @Courtmendoza138 @Courtmendoza138 1 year ago "Ill burn 10." Hahaha oh my god, I was dying after he said that 😂 Reply @robinstuart8941 @robinstuart8941 1 year ago Please like so Dr Sinclair sees this. A few ideas that might be alternative to expensive HBOT (& dreaded exercise) - start a scuba diving hobby using two bottles (1 with enriched air and the other normal air) then follow the Israeli protocol switching between the two at appropriate depth. - start a free diving hobby which involves learning to hold your breath for longer periods of time. I assume one can achieve hypoxia without exercising or climbing in a expensive chamber. Also can be practiced at home, no need for pool. Perhaps bathtub if you wanna be fancy. Note: there’s already large community of divers who use enriched air (30 -40% O2), could be a source to get data. Unfortunately that hobby also comes with a lot of sun exposure… Reply @thanayutmaktheppong8453 @thanayutmaktheppong8453 1 year ago quality content. 1 Reply @foxyone3 @foxyone3 1 year ago Please update your book with all the scientific data that has been developed since the book was published. Reply @jgv10 @jgv10 1 year ago Hey Mr. Sinclair I’m not sure if you ever respond back to comments in this section as this is my first time going into the comment section of one of your videos. But I wanted to know if getting tattoos have any harmful effects on the body? Reply @DaveE99 @DaveE99 1 year ago How often and to what temp do you need to do for brown fat to form? Reply @KAI5ERCHIEF @KAI5ERCHIEF 1 year ago is it ok if we do cardio workout the same day after the resistance workout? 1 Reply @michelem226 @michelem226 1 year ago Are there any studies on just spending time outside when it's hot or cold? Reply @starryfolks @starryfolks 1 year ago (edited) Are you using the concept from Shannon's binary information theory to solve problems regarding the biological loss of information? Interestingly, our genes are quaternary...so it would be fascinating to derive a mathematical equation representing this information. Perhaps an equation could have several parameters on one side (such as the difference in epigenetic info over time, aging biomarkers as a function of stress etc.) and dish out the current state of cellular differentiation and information loss. We could also use probability and entropy theory to simulate the expected age related information loss and identify potential hazards for other secondary issues like diabetes, cancer... This would be remarkable. Biologists, physcists and mathematicians would finally solve the aging disease! Engineers could develop devices to track and provide data (with privacy) to remedy issues instantly. 1 Reply @theshaktinath @theshaktinath 1 year ago love watching this channel, please some light on hair fall and baldness. 1 Reply @pryhosm @pryhosm 1 year ago How does the state induced by stress impact muscle catabolism? I had been "taught" that the same theory of feast and famine triggers the body to burn more fat if eating more frequently. The idea was that when the body senses the scarcity of food it slows the burning of fat, at least for a period of time, as the body first goes to shedding liver glycogen and catabolizing protein from muscle. This catabolism was framed as a negative, particularly for athletes. Does that still hold true? It's interesting to me because it was always discussed in the narrow context of muscle loss, and framed as "bad", however that isn't really looking at longevity. I have used high protein, low carb, 6 meals a day diets to great effect in terms of fat loss but I was wondering if that measure of fat loss is a bad measure of impact on biologic age or longevity. Reply @nae4830 @nae4830 1 year ago I was so tired and took iron supplement, and helped tremendously. I’m vegetarian. Reply @myoshida2010 @myoshida2010 2 months ago (edited) Heat has proven to increase growth hormone, which in turn has studies that point to a decrease in lifespan. Reply @radhakrishnanmanickavasaga124 @radhakrishnanmanickavasaga124 1 year ago Thank you Sinclair 😇 Reply @gabrielmcnulty8026 @gabrielmcnulty8026 1 year ago Binge watching this podcast Reply @JohnLentSelflessHero @JohnLentSelflessHero 1 year ago (edited) Okay I have a question. At one point in this podcast, you mentioned the ATP cycle, fat, heat and uncoupling. I am trying to find the exact quote, but there is no transcript I can find. Anyway my questions is about 2,4 Dinitrophenol (DNP) and the impact it might have on aging. There appear to several older studies on this topic, and at least in obese animals, it seems that DNP supports anti-aging (i.e. increased longevity, improved glucose-insulin-triglycerides plasma levels, decreased oxidative stress levels; Caldeira da Silva et al., 2008). From what I know about the mechanism of DNP, what you were saying about the ATP cycle seems to at least give some basis for believing it might be helpful as a short term intervention. Are there are any more studies on this I can refer to? Loving the subtitles! It's at about 22:00 minutes where you are talking about AMPK registering ATP levels, and getting activated because there isnt enough ATP, then making more mitochondria. So, if DNP prevents ATP from being made at the usual volume, you end up activating AMPK, making more mitochondria, and getting long term benefits including age reduction. Is that right? Reply @gabrielahernandez495 @gabrielahernandez495 8 months ago Good morning doctor David, I am a hairdresser, what do you recommend me to help my body from all the color I am smelling every day, thank you for your knowlege and all your help, God bless you ! I cant wait to read your recomendation about smelling the dye color Reply @13Floresj @13Floresj 10 months ago Thank you! So much! Reply @natashakharitonova @natashakharitonova 1 year ago Sooooo does it mean that breathing using Buteiko method should in theory bring the same benefits as the exercise (in terms of bringing on the hypoxia)? 2 Reply @rebeccacrawford602 @rebeccacrawford602 1 year ago I know that most of the women in the world would appreciate it if you could address cellulite and if you have found anything to eliminate/reduce it in your experiments Reply @BlueGnome42 @BlueGnome42 1 year ago When do you exercise if you are eating one meal day? Before or after? 1 Reply @Jondice83 @Jondice83 1 year ago So, exercise upregulates both VEGF and NAMPT? Is there a difference in the type of exercise that upregulates VEGF vs NAMPT? Reply @gracefulindeed6091 @gracefulindeed6091 1 year ago Thank you so much appreciate this Info Reply @mashafeterman5304 @mashafeterman5304 1 year ago Like your program and information very much, one thing I will like to mention is way sooo much interruption from your Partner in the program it’s a little to intrusive and distracting. Thank you though for sharing such a important information Reply @safaroneall @safaroneall 1 year ago Thank you so much!!! Reply @ruthcastillocastilla2847 @ruthcastillocastilla2847 1 year ago What do you guys think about yoga, and specially what type of yoga has more impact on health and longevity? Reply @aaronscottmatthews7883 @aaronscottmatthews7883 1 year ago ive never heard the proton gradient and the ETC described so simply 1 Reply @youremom5463 @youremom5463 1 year ago But does longevity really translate to optimal quality of health Reply @susanmajewski3717 @susanmajewski3717 1 year ago Great.....thanks a lot sharing all you know. From argentina!!!!! 1 Reply @alexperassolo4104 @alexperassolo4104 1 year ago Gourmet egg Sandwich Ingredients: Olive oil Mushrooms Spinach Bacon 1egg 1 turkey slice 1 cheese slice. Mayonnaise Mustard Jalapenos (optional) 2 slices of bread Butter Cook spinach and mushrooms with oil put them on a plate Cook 1 egg over easy and put them on a plate Then cook one piece of sliced turkey put it on a plate Then cook two slices of bacon or however many you would like in a pan and put it on a plate Get two slices of bread ready and spread mayonnaise on one side and put a slice of cheese on top Build all of the cooked items onto the cheese slice and then put some mustard on top and add cooked jalapenos if you want and then put the other slice of bread on top and then grill the sandwich slowly on low-medium heat. Be sure to butter the bread also For best results use a double-sided frying pan and egg rings. Reply @breathewithchrissyd @breathewithchrissyd 1 year ago (edited) I’m wondering if there are any recommendations for good quality and affordable NMN and Resveratrol. I know Dr.Singclair has said that he doesn’t give brand recommendations (yet, anyhow) but it would be nice to know which brands are good choices for these supplements. I’ve searched and they are not AS easy to find as other supplements. 2 Reply 2 replies @JkBee @JkBee 1 year ago Thanks. What about these things for pregnant and breastfeeding women? Reply @codyjenkins9884 @codyjenkins9884 1 year ago Do you have a documentary yet? Please, Start a live talk show on YouTube. Maybe answer questions. That would be awesome! Reply @tarxen100 @tarxen100 8 months ago Very interesting I am likewise experimenting wiht options of cold, heat, and exercise Reply @pb25193 @pb25193 3 months ago "I'll burn 10" was the best crazy line lol Reply @theleechqueen @theleechqueen 1 year ago Does ejaculation help get rid of iron? Serious question. I heard donating blood helps get rid of excess iron but doesn't ejaculation use up like a liter or more of blood on average? So does it have a similar effect? Reply @user-yc3xg3jd8k @user-yc3xg3jd8k 1 year ago This is better then waiting for a tv series) 1 Reply @BlueGnome42 @BlueGnome42 1 year ago I was taking an iron supplement because I give blood. Should I still take it a few days after giving? And does giving blood also possibly benefit the giver? Reply @kaytilochrie7461 @kaytilochrie7461 11 months ago Are you done with your podcast? Haven’t seen any new episodes drop. Thanks! Enjoying the content. Reply @kyliebuschgens8161 @kyliebuschgens8161 1 year ago Love these podcasts but…. OMG I want a little, cold, dwarf mouse for my friend 🐭 Reply @tarrahwalton7746 @tarrahwalton7746 1 year ago (edited) Dr. Sinclair, I am a marketing intern for a startup SPAC called LifeX Acquisitions, out of Dallas, Tx modeled after your book, to cure aging. Please reach out to me as we would love to share the company with you and have you on our board of Directors. Reply @remymay3632 @remymay3632 1 year ago I'm not clear if I should take 1000mg NMN + 1000mg Resveratrol per day - or pulse at 2000mg NMN + 2000mg Resveratrol every other day. I'm currently taking every other day for the life extension effect - is this correct? I'm taking all my supplements every other day now.... Reply @chanceofd @chanceofd 1 year ago How does/should one eat around exercise? If I am only eating in the evening and I want to exercise in the morning, is that a problem? Reply @khyla9682 @khyla9682 1 year ago What would you recommend iron levels be ideally? Reply @chantalpique @chantalpique 1 year ago I'm age 77, every morning take green tea with one egg into green tea and drink before starting my day and daily walk1 hour to 1,1/2, with 80s dancing music for energy that putting me into when I was age 40s, after working on posture and balancing for .30 minutes and last mental focus for archery shooting, start 7:30 am to 10:30 to 11am,. also, trying to eat one a day Also, I'mquestion and am curious about walking vs. running; this is only my opinion; it isn't running that would be harmful interior organs are shacking or moving longer time? Please, let me know regarding my statements; thank you, Reply @thegoodfellow41 @thegoodfellow41 1 year ago Can you do a vid on anxiety, worry and fear plz? Reply @qeva970 @qeva970 1 year ago Watching your great Podcast while smoking 😹 1 Reply @nidhinair614 @nidhinair614 1 year ago Will drinking Athletic greens in the morning not break my fast if I am doing a 24 hour IF and eating only at dinner? Reply @Freed0mOfS0ul @Freed0mOfS0ul 1 year ago does the production of NAD increase telomere length directly? , or as a byproduct NAD function Reply @Cenot4ph @Cenot4ph 1 year ago (edited) Not mentioning The Iceman when it's about cold therapy is a missed opportunity 1 Reply @gitamitrovic3119 @gitamitrovic3119 1 year ago Does drinking the Athletic Greens Smoothie throw you out of Ketosis? When should you drink the smoothie? Fasting or eating window? Reply @ChineseSe7en @ChineseSe7en 10 months ago I want to know difference between Hyperbaric Oxygen Therapy (HBOT) and Exercise with Oxygen Therapy (EWOT) Reply @r3ggygames812 @r3ggygames812 8 months ago I just tried to sign up for levels how long do you estimate the wait to be for a reply? Aswell how much does it cost? Reply @soulctrlr @soulctrlr 1 year ago What are your thoughts on astragalus lengthening telomeres? Reply @GamerRiffs @GamerRiffs 1 year ago What about semen retention for longevity? Does that have any affect on that? I assume it def does to keep test levels high Reply @leavroc3491 @leavroc3491 1 year ago For hyperbaric, could you do breathing exercise, search either wim hoff or maybe sadhguru on breathing method? Reply @masterfoggy88 @masterfoggy88 7 months ago Everyone come down this is just in case you want to live more of this wretched life! Reply @bilbobaggins7157 @bilbobaggins7157 1 year ago Thank you Sinclair! Hope you don't succumb to the jabs you've taken. Reply @moneytalkswithchu @moneytalkswithchu 1 year ago "Help" by the Beatles is exactly what I picture Dr. David Sinclair would listen to! haha Reply @AnnO-qk8ep @AnnO-qk8ep 4 weeks ago I'm wondering if cold therapy works the same for every race Reply @davidvergel1533 @davidvergel1533 1 year ago I loved the Portland Oregon joke at the beginning 😂 Reply @HTWW @HTWW 1 year ago 3:48 Yasss!!! He gets it! I've made the same mistake when I was like 14 y.o. It was such a yucky chicken yellow-ish hue, omg. I cringe at the memories! But... I don't regret it, somehow. Reply @CA-lf7jt @CA-lf7jt 1 year ago (edited) QQQQ a teen girl w low iron, and prescribed OTC iron- what level would be safe to take, and ultimately iron number ideal for health and anti aging. You mentioned taking certain times of month- then back off to next month ? Reply @fernandoalmaguerIII @fernandoalmaguerIII 1 year ago It's funny that he says cold showers are unpleasant lol well yeaaah ;) thank you for these podcasts Dr. Reply @connieacevedo4709 @connieacevedo4709 10 months ago Is taking amino8 supplement beneficiary to the body? Reply @althe @althe 1 year ago The optimum level for ferritin is 50 nanograms per milliliter. Reply @whatthefunction9140 @whatthefunction9140 1 year ago I love sitting. I meat really love sitting. It's my favorite thing to just sit and chill 😎 Reply @hamidman6974 @hamidman6974 1 year ago (edited) I am a very chill person. Born in 1994 - I am very fit, I could even say elite. 186cm / 85kg / 6pack - I can run 3000meters in 10 minutes. I can play an intense 90 minutes football match and be the guy with highest work rates. HERE'S THE PROBLEM: My resting heart rate is high like 75 bpm. Something more about me is that by playing a lot of football and neglecting stretching - my muscles are very stiff, especially in the hips area. Why is my heartrate so elevated? How can I bring it down? Could it be related to the fact that I rarely do stretching/foam rolling? Reply @SherrickDuncan @SherrickDuncan 8 months ago Is drinking ice water while ice bathing simultaneously even better? Reply @aboulseem8033 @aboulseem8033 1 year ago Can excessive sauna bathing affect fertility in men? 1 Reply @PedroD25B11 @PedroD25B11 1 year ago There are many things that can activate the genes that accelerate our biological clocks, such as Iron and Protein but I get confuse of how much should I consume per mass, since these nutrients are essential for a well being but we don't want high level of these. How to I find out the right amount of nutrients to activates my goals such as a better lifespan and a healthier life, since I feel like most of nutritionists aren't fully aware about this type of diets, or at least I think so 1 Reply @kingakorska @kingakorska 1 year ago Non-substantial side note: the intro to this podcast reminds me of Monty Python's "It's the mind" 🤓 Reply @rkeit002 @rkeit002 1 year ago I was wondering for women what time of the month is optimal for taking Fe supplements Dr Sinclair Reply @sauliusplevokas6188 @sauliusplevokas6188 1 year ago But if I eat 2500 KCal per day it's pretty difficul to eat that big meal in one time 🤔 often I struggle to eat that amount of calories in 2 meals. 2 Reply @DiAna-im1vv @DiAna-im1vv 1 year ago David can you please talk about red light therapy? 1 Reply @UBI_NOW @UBI_NOW 1 year ago the #1 mistake with new utubers is to make lengthy post- bit size breakdowns are one of the best ways to attract new viewers have both poor lighting is #2 - U don't need to turn ur studio into a burlesque show or a cold lab but less "over lighting" & more colors are as much valuable as expensive mics & cameras, it offers a more warm and welcoming ambiance 🖖❤ Reply @snowwhite8143 @snowwhite8143 1 year ago Im watching this and shivering from the cold. Reply @adamw2030 @adamw2030 1 year ago New favorite podcast. Well... tied with Huberman Reply 1 reply @phlevel1 @phlevel1 1 year ago (edited) I wish we can be in the future already with synthetic bodies and no maintenance. 1 Reply @frederickhofmann843 @frederickhofmann843 1 year ago appreciate the segmentation Reply @jawadkarim6615 @jawadkarim6615 1 year ago Best Scientist Ever..... 1 Reply @lizmallen3461 @lizmallen3461 1 year ago Meditation reverses telomere damage as well! 2 Reply @thebossiam2960 @thebossiam2960 1 year ago Please podcast with Leo and Longevity 2 Reply @BloomByChristine @BloomByChristine 1 year ago What about the difference between iron and ferritin? 1 Reply @thegoodone55 @thegoodone55 7 months ago Sinclair: "people with hemochromatosis could benefit from donating blood..." My brain: "apply the leeches!!!" Reply 1 reply @macaronafterparty @macaronafterparty 1 year ago Do you support Wim Hof's breathing method for increasing oxygen in the body and tolerating extreme cold? Reply @lindalabrosse9522 @lindalabrosse9522 1 year ago (edited) What do you think about Wim Hof’s method of breathing? Would’nt be similar in effects, of hypoxia? Reply @fernandoalmaguerIII @fernandoalmaguerIII 1 year ago Dr. SINCLAIR so around what age do we stop being able to create new blood vessels? And taking NAD precursors will reverse this? Reply @BeeBopGaming @BeeBopGaming 1 year ago “I don’t eat breakfast or lunch, and I just focus on dinner”. 20 seconds later…. “I drink this product every morning” lol. Make that money my dude. 😂 Reply @alohagrace2225 @alohagrace2225 1 year ago Get off your ass!🔥❤️‍🔥🔥 62 and loving life. I gave up driving in 1998 and choose to live within 2 miles from where I work. I ride my beach cruiser bike and walk everywhere. I am always amazed how people tell me those are strange choices, yet clearly they are healthy choices. I look far younger than most my age, but more importantly, I feel younger. Your health is your wealth. We must take accountability for our own health and happiness. Love this podcast. I did a lot of intermittent fasting in my youth, not understanding how healthy it was for me, I only knew I felt better while doing it. Thanks for explaining it all here. Reply @bethaustin1884 @bethaustin1884 1 year ago Does steam have similar benefits to a sauna ? (Owner of steam shower asking 😀) 1 Reply @geoffmalone5212 @geoffmalone5212 1 year ago Good afternoon Dr Sinclair, First let me say I loved your book and I am finding your podcasts amazing. My question is: lots of people say stressing your body is so good for you for several reasons, heat, cold, hunger etc. But no-one mentions if dehydration can benefit you? Reply 1 reply @anibis485 @anibis485 1 year ago I understand the hypoxia theory but how long is the state of hypoxia advised? . In order to get the benefits of it and not the negative side of it? Reply @octaviatheappalled912 @octaviatheappalled912 10 months ago Star Trek for the Winnnnn!! Sorry, sorry sorry. I just love when fa ST nerd unmasks! (Thanks to both of you for the work you do). Reply @lubo955 @lubo955 1 year ago I just received my resveratrol (1000 mg) but the color is yellow. The product is best to use before 05/2024. The ingredients are: Resveratrol, Microcrystalline, cellulose, Carboxymethyl, Starch Sodium, Magnesium, Stearale, and Black pepper extract. Do you think that this product is good to use? Reply @captainpike2468 @captainpike2468 1 year ago HIIT training is very unfun but best way to ‘become hypoxic “ 1 Reply @guyemry7947 @guyemry7947 10 months ago I wanna be civil and respectful, but … the Raiders? Really?! 😝 Go Broncos and thanks for the awesome work you guys do! Reply @royalthomestead @royalthomestead 1 year ago Sinclair, you mentioned you take your AG1 in the morning does that break your fast?? Reply @susanmajewski3717 @susanmajewski3717 1 year ago Is hypoxia related to Wim Hof way of breathing? Is it why it so good to do it every day? Reply @adbc8737 @adbc8737 1 year ago Thank You! 🌀💚🌀 Reply @qijingfan5656 @qijingfan5656 1 year ago I'm gonna be very excited if you can give a hint of a trustworthy supplement brand name 1 Reply @mathieukress547 @mathieukress547 1 year ago Hello :) I like to tweak the saying "what doesn't kill you makes you stronger" by saying "what doesn't handicap you makes you stronger" Reply @compassionsix @compassionsix 1 year ago You mentioned prolonged fasting. What about gallstone risk? Reply @afrommi2275 @afrommi2275 1 year ago Are you acquainted with or have read a book published by Durk Pearson & Sandy Shaw in the 1980s called The Life Extension Companion? We read that book when it was published. We were impressed. But I don't think it has extended our life. There are so many things that makes a lot of people live longer and many others that will make our lives shorter. If you do have a way for us to reverse genetic and environmental damage it would be amazing. We are in our 70s and our chances of success are limited. Thanks for the series. Good luck! 1 Reply @donotmissDutch @donotmissDutch 1 year ago Question from the Netherlands: I also do have some tattoos. But is it good For Your Health? I mean do you have to detox them? I already have got rit of my piercings Because Of The heavy metals they are definitely not good. Reply @lisalove1491 @lisalove1491 1 year ago (edited) You're very cute David Sinclair!!! Your practices and research all look good on you! I am following your advice so I can be the same in my 50's. You are impressive on many levels. Reply @theartofancientegyptianmet1747 @theartofancientegyptianmet1747 1 year ago What is the correct level for Vitamin D? Some recent studies have found that most humans in the Northern Hemisphere are Vitamin D deficient. They recommend between 4,000 — 10,000 International Units. 1 Reply @yourcoachbladimirsantos5136 @yourcoachbladimirsantos5136 1 year ago Does anyone knows where david is getting the supplements from? Reply @katherandefy @katherandefy 1 year ago What about electrolytes? I tend to lose potassium. Which may not be related. Reply @JacobNeeser @JacobNeeser 1 year ago Waiting for Derek from MPMD to do a natty or not on David Sinclair Reply @SherrickDuncan @SherrickDuncan 11 months ago I have no central heat and air in My home or car. I work outside in Oklahoma hot humid summers and winters and don't wear a proper jacket in winter. And I often have to go up to 30 days without food and with just water. And only ever eat one meal tops every 23 hours when I do eat daily. I call it being on spousal support. 😅 But glad to know it is why I look much younger and am never sick. 🤷🏾‍♂️😅💁🏾‍♂️ Reply @shootingstar5017 @shootingstar5017 1 year ago I love hearing this information from such people, full of knowledge, based on research and even tried on themselves Reply @dover1129 @dover1129 5 months ago they had a sauna competition here in finland way back, and the russian died and the finn had to go to the hospital, so you can over do it :) Reply @mattward5010 @mattward5010 1 year ago David could you hold your breath while walking to boost AMPK? 1 Reply @krutillar @krutillar 1 year ago Got a standing desk. Stood for a few weeks and my knees got destroyed. Is standing bad for knees? Reply @stoek @stoek 1 year ago (edited) It's good I life in the north, I can just go outside for a cold therapy. Saunas are amazing, glad it's my culture Reply @tammyglaude7266 @tammyglaude7266 1 year ago Do you believe MTHFR mutation is real and plays a role with longevity? (They say you can’t take Metformin with an MTHFR mutation and that synthetic NAD will not break down with MTHFR mutation) Reply @brosirs @brosirs 1 year ago "So your average person will burn 20 calories, I'll burn 10..." 😀 Reply @marionannmacredie @marionannmacredie 1 year ago If I am unable to fast do I get the same benefits by restricting calories with every meal??? 🌹🌹🌹🌹🌹🌹🌹🌹🌹 Reply @samatoid @samatoid 1 year ago The older you get the longer you spend on sex (when you have it which is probably not as often). It's definitely not 5 minutes - physically 5 minutes is impossible for most. Reply @blackjack6406 @blackjack6406 1 year ago If Hyperbaric pressure chambers work, is there a difference between people living on sea level vs people living at high altitudes? Reply @nicholassteel5529 @nicholassteel5529 1 year ago Is the Wim Hof breathing useful given that you guys talked about hyperbaric chambers?…..✌️ Reply @user-hl3pv7ct1w @user-hl3pv7ct1w 1 year ago Should an Alcoholic like me try to drink a single glass of wine each night for longevity? 🤣 🍷 Reply @sallygriffen5932 @sallygriffen5932 1 year ago HOW MUCH TIME PER DAY AND PER WEEK ON THE 3RD PART - MUSCLE BUILDING? 1 Reply @philfisher @philfisher 5 months ago (edited) You mention taking AG1 every morning. Does this not break your fast? Reply @kittyvine823 @kittyvine823 1 year ago Matthew needs to let the David speak, finish his thought; I hate interruptions and LaPlante is good at it. Reply @ShaneHarveyMusic @ShaneHarveyMusic 1 year ago So if you’re drinking Athletic Greens every morning as mentioned in the Ad then how are you also fasting till dinner? Reply @AnkushSharma-zv5hv @AnkushSharma-zv5hv 1 year ago keep going. Reply @murrmurr765 @murrmurr765 1 year ago Why do you look so disappointed? We love you, David and co-host! 2 Reply @andrearicciardi6881 @andrearicciardi6881 1 year ago Anyone suffer from IBS here ? Any tips ? Ty so much Reply @lamouralice4533 @lamouralice4533 1 year ago May I know about the study happening in Israel is also about pressure effecting the amount of oxygen intake in chambers? Reply @rupertrivett4679 @rupertrivett4679 1 year ago Im confused David, you said that you only have one meal a day in the afternoon, but you have athletic greens for breakfast ? Reply @leadimentoobrien1221 @leadimentoobrien1221 1 year ago Pls do a video on kidney health Reply @ceebeedee5587 @ceebeedee5587 1 year ago Dr. Sinclair, I often hear you say that the secret to living younger longer is: Eating less often. I find that ambiguous but in a nice way. Do you mean a.) eating less food, meaning smaller quantity or lesser calories, most of the time or b.) eating food but not as frequently, like intermittent fasting? Reply @milevaerceg4675 @milevaerceg4675 1 year ago Looking forward to episode about hair. Reply @solitarywitch @solitarywitch 1 year ago Any idea when Levels will be available in Nevada? 🥺 Reply @DaveE99 @DaveE99 1 year ago Good to hear he does weights every other day. Was wondering about this and mtor. My question is does he follow progressive overload, I ask cuz david dosent look like a jacked dude by any means. Reply @SilhSe @SilhSe 1 year ago 3:50 🍊😪🍊😂😂 the things we do during quarantine ! Reply @falconone7230 @falconone7230 1 year ago (edited) Do Nad supplements/Tru niagen start autophagy even if you eat 6 small meals a day without exercise? Reply @tuluigamaka2294 @tuluigamaka2294 1 year ago (edited) Do you drink water tea or coffee when you are not eating 16 to 18 hours? I hope you answer my question pleeeeze Reply @TheLegendaryLinx @TheLegendaryLinx 1 year ago FYI David's real age is 154 and the guy with glasses is 131 Reply @soundtenement7993 @soundtenement7993 1 year ago Question: Can you buy a Dive Hyperbaric Oxygen Chamber? If you can what would you recommend? Reply @softboisam @softboisam 1 year ago The average length of sex is only 5 minutes? I couldn't imagine the amount of time I'd save if it were that short in my relationship Reply @ralfizeg @ralfizeg 1 year ago Talking about free radicals, David: "and we're not talking about Portland Oregon" 😂🤟 Reply @mmags @mmags 1 year ago Doesn't Atheltic Greens break your morning fast? 1 Reply @wander4evr814 @wander4evr814 1 year ago (edited) In his commercial he says he drinks it every morning. Then he says he only has coffee and yogurt then just dinner. Just curious which is it. 1 Reply @matthewferguson7084 @matthewferguson7084 1 year ago Athletic greens doesn't ha ve lots of Iron I hope.. Love the podcast thank you Reply @roberttravistext5091 @roberttravistext5091 1 year ago All you got to do to stay healthy is eat more fruits, keep the ph about 7+ and move . Reply @jacquesfourie867 @jacquesfourie867 7 months ago What do you think about cardarine as a supplement Reply @tom1olo @tom1olo 1 year ago We get our annual dose of cold in Chicago. 2 Reply @cedb3360 @cedb3360 1 year ago Sinclar would make an excellent Elven cameo. Just saying... Reply @gracegwozdz8185 @gracegwozdz8185 1 year ago Instead of hyperbaric use normobaric chamber. Reply @dominicspagnuolo2837 @dominicspagnuolo2837 1 year ago question - Athletic Greens - does it break a fast? Reply @kazykamakaze131 @kazykamakaze131 1 year ago Wow most people only have sex for 5 mins? Geez that is low, most men are quick. For me it's a mission, I am generally closer to 40-50 mins and I am dripping with sweat half way in. Don't know about most, but sex for me is a workout and I go to the gym 5 times a week. Reply @Hambastegy @Hambastegy 1 year ago 🙏🙏🙏 Reply @noahweaver2019 @noahweaver2019 1 year ago You talk about comfort and today’s society being the worst for longevity because we aren’t in survival mode very often. If that’s the case, why has the average lifespan gone up? Not critical, just curious. 1 Reply @okoiful @okoiful 1 year ago Would you be open to having a podcast with Dr Greger from nutrition facts? Reply @edumontero2953 @edumontero2953 1 year ago does david offers private consultations for high earning individuals? just wondering Reply @robbass40 @robbass40 1 year ago Love that Raiders hat too! Reply @zohrehrostami9683 @zohrehrostami9683 1 year ago How about people with thalassemia, what should they do, as well as folic acid Reply @inikalinden7335 @inikalinden7335 1 year ago Can you do an episode on some of the things dr Gabrielle Lyon is saying? Like we need at least 40g of protein per meal in regular doses throughout the day to build muscles in particular when only mildly excersising, mtor activity is good for muscles growth and we need higher amounts of skelleton muscles, that there is no good new study that suggest animal protein is causing cancer and all studies which do are epidemiological studies where processed meat and bad lifestyles choices where thrown together with grassfed organic meat, that plant based people have lower muscle mass and therefore more prone of landing in a wheelchair, that cholesterol nowadays is not solidly seen as bad and there is shift now in science? I’m too confused Reply @SeabornProductions @SeabornProductions 1 year ago But how do athletes entertain this lifestyle while retaining a high level of performance? Or even high level performers like special operation soldiers (navy seals, green berets, etc). ? Reply @patriciacell3303 @patriciacell3303 1 year ago 🙏🏻🙏🏻🙏🏻💚 Reply @simpleman7203 @simpleman7203 1 year ago Had doubts about the other guy< Matthew LaPlante, but he said he is a big soccer fan that's wassup w me. I respect Americans who are into OG football Reply @carbon1631 @carbon1631 1 year ago Awesome info 2 Reply @victorperea1165 @victorperea1165 1 year ago I don’t understand; Sinclair says he skips breakfast but has also athletic greens in the morning? Can you explain that? Reply @kenswanston820 @kenswanston820 1 year ago Why is there so much emphasis on glucose as an energy source to the exclusion of ketosis. If you are on a low carb (Dr. Eric Westman - Purdue University) Keto diet the body can switch to using ketones INSTEAD of glucose...does this make a difference to your aging thesis? Reply @magdacabezas1779 @magdacabezas1779 1 year ago Are there any studies with anti aging protocols in women??? Reply @yournate @yournate 1 year ago Is it bad that as I listen to this I'm eating a big plate of pancakes?! 1 Reply @bartoszulkowskitattoo2044 @bartoszulkowskitattoo2044 1 year ago i am waiting for next episodes as i am waiting for A PREMIERE of a NEW MOVIE!!!! 2 Reply @wmp3346 @wmp3346 1 year ago Little surprised by David’s partner, not what I would have expected 1 Reply 2 replies @wednesday6018 @wednesday6018 1 year ago That intro is just so beautiful chef's kiss 1 Reply @tenminutetokyo2643 @tenminutetokyo2643 1 year ago Dave can you do one on HGH? Reply @dejorn @dejorn 1 year ago I’m confused by what you say about not eating breakfast and lunch Proff Sinclair, but then you say you have athletic greens every morning. Is that not classed as breakfast? Reply @philllove528 @philllove528 4 months ago I work out all the time. Reply @strabe @strabe 1 year ago (edited) Sadly many of the sponsors products or services are only available in the USA. Some of the inside tracker info can be calculated from data you upload so that should be possible but anything requiring DNA tests is problematic. Reply @KitasakuOnlineKO @KitasakuOnlineKO 1 year ago The car analogy was a good was a good one to use @35:50 Reply @patriciacell3303 @patriciacell3303 1 year ago 💚💚💚🙏🏻 Reply @mickmack9333 @mickmack9333 7 months ago some contradiction here, you cannot make the VEGF pathway work again by exercising when u r older, but then David says he discovered that u can restore the VEGF pathway by producing NAD by exercising..... this doesnt make sense...... 1 Reply @juanpabloreyescarrera8329 @juanpabloreyescarrera8329 1 year ago What if I just donated blood. Would it be advisable to supplement with iron then? 1 Reply @ExbotHero @ExbotHero 1 year ago (edited) 3:04 Free radicals... (UC) Berkeley... LOL! (The more the better, right?!) Didn't know I loved free radicals, but hey (or did I?!)... This channel seems to give me a new perspective every time I listen to it. Great news David! (At least I still dislike too much of them in my body, right?!) Reply @jaor727 @jaor727 1 year ago Physical Activity and Senescent Cells 47:50 --- You mentioned there would be a link to an article in Aging Cell about physical activity and removal of senescent cells. Do you have time to point that out? I don't see the link. 1 Reply @frenchmontana423 @frenchmontana423 1 year ago hi is the episode about the cosmetics / hair skin out yet? you said you would discuss it? thank you Reply @MrMike44v @MrMike44v 1 year ago i guess wim hoff breathing exercises helps with longevity genes too Reply @dajesz.pawciu @dajesz.pawciu 1 year ago Hi, somethig is not clear for me. I think you should distinguish starving time from calories supply. As 80 kg man when I provide to my body 2600 calories I am in my zero calories state. I am not gaining or losing weight. It does not really matter if I provide this calories with one two or more meals during 4, 6 or 8 hour time period. It is about calories. Eating less than 2600 calories I am starving. Starving is not about eating less often it is about calories sypply. You do not touch this issue at all. Next thing is that you can not build muscles when your body is starving. In my case below 2600 calories. Every bodybuilder knows it :). Greetings from Poland! Reply @kyrgyzsanjar @kyrgyzsanjar 1 year ago There’s some serious bromance going on between these dudes! 1 Reply @marinafoglietti9351 @marinafoglietti9351 1 year ago (edited) Mediterranean diet is plenty of sugar: bread pasta pizza and a lot of fried fish and steak, a lot of milk and cheese an fruit. Reply @rasheemmcdowell4144 @rasheemmcdowell4144 1 year ago Should men get phlebotomy? If so, how often? Reply @theunsvanrensburg7455 @theunsvanrensburg7455 1 year ago I love these podcasts....but, for someone who has always been into fitness there is basically nothing David has to say that has not been out there for a long time! Maybe he can "geek" it out more than others, but really...cold exposure, low carb, metformin, Gh, peptides, sleep and circadian rhythms, O2 hyperbaric...etc etc people have been onto these for ages! I am holding my breath for some "breakthrough" finding! and I would like a debate about David's view on mTor and Dietary advice, with respect, it is lacking!? Reply @dingjaoping @dingjaoping 7 months ago CA$1.00 Thanks! Reply @eziocantella4482 @eziocantella4482 8 months ago If metformin and exercise work through a small “damage” to the cell which is unable to access atp is supplementing with creatine “bad “ for longevity since it creates “ abundance “ of ATP?? Reply 1 reply @anandk5536 @anandk5536 1 year ago I have many questions. 1 high level of oxygen is good? 2 Surplus calories intaking is vital for hormone health, whereas calories deficit is necessary for longevity. How can we get optimal calorie intaking level? 3 One likes to do running/vigorous workout in early morning. How it is possible that they have only dinner. 4 Whether one has physical work lifestyle. How they can do long fasting. I love to get teach me. Could anyone answer? Thank podcast team very much. Reply @rickyu1978 @rickyu1978 1 year ago "ill burn 10" 😂 38:38 Reply @Rich7714 @Rich7714 4 months ago @22:00 - "Just get up off your arse - it's not that hard." Please try telling that to my factory bosses David! All they're doing nowadays is trying to shorten the number of steps we take!!! Reply @danielauza @danielauza 1 year ago can you comment on pranayanas and the Wim hof breathing method ? Reply @sovereign775 @sovereign775 1 year ago Sinclair says HIIT but going off of what they describe of panting - it is more in line with moderate intensity. Especially since he mentions 70min of HIIT?! This is damn near impossible if we are talking about true high intensity where giving it your all last 10-20 sec. I'll do a HIIT workout if 25 min with 10 sec all out and 50 sec break on the bike. That is only 250 sec of true HIIT. Imagine doing 70 min of true HIIT? If you know your moderate intensity vs your high intensity then you know how the 70 min rec is more in line with the moderate intensity. Reply @user-hl3pv7ct1w @user-hl3pv7ct1w 1 year ago (edited) Your voice is full of life…… And I’m the queen of England. Lmao 🤣 Reply @penmaenmawrdefiant1146 @penmaenmawrdefiant1146 1 year ago What do people think of Oxygen Concentrators? Widely available, are they of any use? Reply @danguidi2 @danguidi2 1 year ago Imagine having to be the finish carpenter in that room, so many damn corners... Reply @mustavogaia2655 @mustavogaia2655 1 year ago Couldnt apnea mask be adapt to hyperbariic therapy? Reply @marinafoglietti9351 @marinafoglietti9351 1 year ago (edited) I would like to know what do you mean with plant based? Beans and other like these? These contain a lot of iron and are no good for me, salads and other raw or cooked vegetables ? We can't live without any animal protein. Cheese it's no good too, because it contains lactose that it is sugar and cereal it's the same, a lot of sugar. I can not understand what we have to eat. I was vegan/vegetarian for about 30 years and I had a lot of deseases. Heartbeats always under 60 and sometimes under 50. No energy at all, inmsonnia. From a couple of years I have began to eat eggs, fish and meat in small quantity and now I have no problems. All it is normal now with these supplements Vit C 9 mg, vit D3 5000 uj k2 mk7 200 uj every day. Reply @johnfradkin3003 @johnfradkin3003 1 year ago (edited) I loved the book and generally find all of Sinclair's talks to be fascinating. However I must say that the commercials in this series really detract and cheapen these videos. I do not understand why a famous scientist like David Sinclair needs to be pushing products shamelessly. It can't possibly cost much to produce this series of videos so I don't buy that as an excuse. Reply 1 reply @peterpiper5300 @peterpiper5300 4 months ago does taking athletic greens in the morning end a fast? Reply @gloria6396 @gloria6396 1 year ago A GENIUS EASY TO FOLLOWED BY NON SCIENTISITS LIKE ME MAKES EVERYBODY GENIUS UNBELIEVABLR Reply @RorschachRev @RorschachRev 1 year ago Hyperbaric Oxygen Therapy above 2 atmosphere increases stem cell production 18-25x. Reply @briantanzer5599 @briantanzer5599 1 year ago I think calorie restriction is important but eating once a day isn't feasible for most people. Can u still get similar biochemical and physiological benefits from calorie restriction but still eating every few hours and spreading calories over several small meals? Are u collecting data over years where u are following people over time to see if these theories pan out? Reply @dr.sammypryor @dr.sammypryor 1 year ago Haha, Matthew LaPlante said, "I would burn 10." A little self-deprecating humor! Reply @mlkalt1143 @mlkalt1143 1 year ago Thanks guys for the knowledge. Thank u. GNL crypto Reply @ariperez9663 @ariperez9663 1 year ago Goku has been using the hyperbaric time chamber for decades ;o) 1 Reply @dipokfavs7385 @dipokfavs7385 1 year ago Sir what is your opinion on semen retention 1 Reply @jackbuaer3828 @jackbuaer3828 1 year ago I think David is incorrect regarding the inability to overdose on heat or cold. I have a sauna and a cold plunge set up. I do one or the other daily. Of course, you can overdose on heat and / or cold therapy. Hyperthermia and Hypothermia are real. Besides those two pathologies, too much stress, whether heat, cold, exercise, or nutritional, will undoubtedly be harmful. The trick is to find the optimum dose. Have I overdosed before? Yes. You get the same symptoms that you would get from overtraining with exercise. Reply @patrickellah9803 @patrickellah9803 1 year ago ‘’ We don’t have to run from predators very often and this is a real problem ‘’ This statement to implies that that cave men who lived with more ‘stressors’ should have lived longer ? It’s historically documented that the average life of prehistoric man was about, 25 years? Maybe they were all eaten by predators? Great podcast though. Reply 1 reply @lylan8737 @lylan8737 1 year ago When i don’t eat meat and eat more vegetables or if i fast about 18 hours i have sleep problems. I can’t fall asleep and even if i sleep i wake up easily and don’t get deep sleep. Only when i eat red meat and more food i get good sleep. I’m women in my thirties and i really wana fast a little and eat less meat. But due to sleep problems i can’t. Please address the sleep issue please. thank you 1 Reply @tonykomer2997 @tonykomer2997 3 months ago Does he bother mentioning intense excercise trigger mtor. As I stated before mtor is not bad or good. It's needed for life duh!?! It's just like blood glucose high chronic levels are what's bad. It's a wax and wane of the various biochem cascade that is needed. Short stimu,action followed by longer period of repair rinse wash repeat. Reply @antoniodossantos5960 @antoniodossantos5960 1 year ago Thanks 🌎 Reply @fingerprint5511 @fingerprint5511 1 year ago It stuns me that humans truly believe they can extend their lifespan when its all in the realm of imagination. This is pure Primal brain fear motivated and all because of a fear of death. Not one human out if billions has been successful in this fool's parade of an idea. The body will get sick, old, if it is the way nature planned, and die. Observing front row for a few decades, people trying to beat reality is a very sad way to use your life. Reply @johnmartinsen7623 @johnmartinsen7623 9 months ago Why are you afraid to have a conversation with Dr Paul Saladino? He makes some good points that you clearly don't want to acknowledge. Upton Sinclair said it best..."It is difficult to get a man to understand something when his salary depends on his not understanding it." Reply 3 replies @kamanashisroy @kamanashisroy 1 year ago Samething happened , stood all day, piriformis muscle strain .. Still doing piriformis stretch . Reply @tonykomer2997 @tonykomer2997 3 months ago Got love when guest chose to hunt and peck information such as the effects of motor. HE starts BBAC are bad and MTOR is bad. Well guess what no MTOR then no muscle repair no muscle adaption i.e. getting stronger repairing tge damage from a workout. Mtor is needed. Now if he stated chronically elevated MTOR then yes. But no for these people it seems absolute. Once they start the "everyone needs to become a vegetarian" I stop listening. We have been as humans eaten a primarily meat diet for countless millenia. It's what caused our increase in brain size and our reduction in gi system size. Just compare promagna to homo sapein. Or compare it to chimps or great apes. This is not gues work but proven with full support. All the proof he is mentioning is from epidemiology studies. You can ne er form definitive conclusions off of these types of studies. Yet people love to use it for their goals. Rather than searching for truth they search to prove their theory2. That's not how science is suppose to work. It's the same with how big pharma has corrupted the research community as a whole. Reply @mehmetpazar3225 @mehmetpazar3225 1 year ago All I want to know the names of all of your supplements please and I also want to know why coffee still have antioxidants and minerals even after it is rosted Reply @OIOnaut @OIOnaut 1 year ago I get it. David is talking to the masses. Respect to that. To the 88% of urban adult pre pre pre diabetic people, who do not get it, this is enough. I also get most of the ideas, but do not agree with all he says. One thing I do not get is his mania for veganism and red meat bashing. I am a die hard 100% red meat carnivore ex sick ex keto and just as he has taken the vegan route, good for him. I have optimised for health. I am no opposer to plants but is was not for me at all. I have searched the nutrition science too and put my bet on a more non-modern living mimicing life style carrying most elements talked here and which has insulin by its throat. A kind that is way more spatan than that David claims to have done himself. It also seems that we have different history and thus fundamentally diverging pathways to health goals. Remember that longevity is not the same as vitality nor is it synonymous to a quality of life in person years gained. What is the goal? To live an eternity? No supplements no disease, no signs of illness or avoiding sickness till the end? We are on the same life raft picking in some of the survivors of S.A.D. Titanic. Am I better? Hell no! Do I live a healthier life with less disease, or prosper longer? Time will tell. My way of living is so alien to most people living in a comfort bubble that it is not an option for the masses. So if you are part of the masses, do note that David is overly simplifying matters for the sake of profit and possibly with a viewpoint ladden with a whole lot of healthy history a user bias as most plant based diet advocates do by missing the parallels in real food approaches by simplifying iron regulatio , mTOR, PI3K and AMPK that drive cancer in most combining states. N.B. that there is only one combination out of possible 8 that does not promote sickness. And it is not determined by food categories. it is determined by the programming of physiological body biochemistry signals. When on a full and controlled carnivore this is that happens. It can happen with following David’s way too. Do what works. Learn to do it. Do heat shock protein and cold shock protein activation. Do starving mimic eating. Do not eating all the time every time, do something. Do real food hunting and gathering ... and you see that red meat is not (what you see is all there is) thing and only now you see the larger context where any proper diet works. Do your homework and it is only beneficial to you. My exersize is not done by hyper oxigenation or making the blood alkaline, it is done 1) by oxidating deep out with a prolonged exhale when performing slow and low energy meditation but also when doing resistance training with high intensity and 2) by hyercapnia training when doing fast cardio. It is awesome even if it feels very discomforting at times. My cold plunges are now closer to a half an hour in the freezing sea water. I over do it a lot and do pay the price in equstrian type pannicilitis, but it pushes the boundaries of my mitochondria and enables more BAT i.e.brown decoupling capable fat tissue generation. There is no need for glucose control with 0carbs eating. My body makes its own glucose, cholesterol, controls all my electrolytes, iron molecule production and much much more all with no need for ANY commercial products. Lastly it is hydronium ions not electrons, not hydrogen ions that signal ROS in ETC. To my best knowledge Peter Dobromylskyj’s blog ,Hyperlipid protons chain, is owning it. So to ask is David is little out of his expertise here is justified and I want to remind all he is not the longevity god, just a mortal human doing his best to live well. Aren’t we all. Had better start to look for younger friends. The ship is sinking fast. Reply @NVSTGTE @NVSTGTE 1 year ago (edited) I’m not loving this LaPlante guy. His voice, his comments…I want to love this podcast! Anyone agree? I think it should just be Dr. Sinclair himself or with various guests. Reply @laviniadovan850 @laviniadovan850 1 year ago new episode, yey! 2 Reply 1 reply @bendikkirkbakk1833 @bendikkirkbakk1833 1 year ago i have heard and practice dinner/the big meal at brekfast. 16:8 end with a salat type meal Reply @farzinphotography @farzinphotography 1 year ago Thank you David Sinclair Reply @19stoak @19stoak 1 year ago Uhhh... may be I just have a heck of a lot better doctor than you and a lot better insurance but I get pretty involved and intricate labs every year with a regular check up. I am also in my 50s, am very healthy, and have a resting heart rate in the mid 40s. Labs are not due to poor health. I sure as hell would not see a physician that simply asked me if I fetl good and said come back in a year. You need a new doctor. Reply @dnicolle @dnicolle 1 year ago I liked the information but if you drink Athletic Greens every morning then technically you are not fasting until dinner time. Reply @aselaptl @aselaptl 1 year ago Thank you Reply @snakeandturtleqigong @snakeandturtleqigong 6 months ago Thanks so much Reply @fleadoggreen9062 @fleadoggreen9062 1 year ago What about drinking milk ? Regular milk ? What about alcohol ? Reply @NancyLopez-ky3ws @NancyLopez-ky3ws 1 year ago Confused. Do you take athletic greens in the morning? wont that break your fast? Reply @er66an @er66an 1 year ago So interesting Reply @marylafferty88 @marylafferty88 1 year ago david you look brilliant I would say you look 32-40 years young … Reply @Mario112352 @Mario112352 1 year ago If oxygen deprivation is positive to the body functioning then why do why does sleep apnea cause heart issues like afib. Reply @firstlast5322 @firstlast5322 1 year ago 🧡🧡 Reply @jungletheme2094 @jungletheme2094 1 year ago Free the information! Yes! Reply @beachboxrealty @beachboxrealty 1 year ago I am going to get Atheltic Greens. Reply @francischen3819 @francischen3819 1 year ago Thank you Reply @XeL_Vegan @XeL_Vegan 1 year ago Plant based diet. LIKED SUBED SHARED Reply @stevestephens8925 @stevestephens8925 1 year ago he says he skips breakfast and then says he starts day with 'green' drink and a very small amount of yogurt. clearly not skipping breakfast. Reply 1 reply @MsAdo1 @MsAdo1 1 year ago If hypoxia is good - why not just hold your breath? Reply @prevengeix8551 @prevengeix8551 1 year ago Wow! Sex burns 4 calories a minute? That's almost 20 calories per session. 1 Reply @ivanandreevich8568 @ivanandreevich8568 1 year ago Thanks for the hair lulz, Dr Sinclair Reply @Tanner8585 @Tanner8585 1 year ago We need to listen to him. He looks like a teenager Reply @mikaelnovak6287 @mikaelnovak6287 1 year ago 6.08 ”I don’t eat breakfast” …and then… 7.30 ”I eat athletic greens every morning” Doesn’t athletic greens with 50 cal per serving disturb your intermittent fasting? 🙄 Reply @omkarki1516 @omkarki1516 1 year ago I m 33 . I want to stop ageing. Just fasting, exercise, cold shower, or very hot shower like sauna will enough for that.? 1 Reply @ycc9369 @ycc9369 10 months ago Flaky, business oriented. Become happiest person and live longest in 60 years. Reply @salsipuedes8425 @salsipuedes8425 1 year ago How can i fast if i lifts weights and i dont want to lose my gains ? Reply @htchamber2776 @htchamber2776 1 year ago Dedicate an episode to sleep! Reply @mosuutjuh @mosuutjuh 1 year ago 👍 Reply @manuhonkanen2111 @manuhonkanen2111 1 year ago The strongest man in Finland Mika Törrö is an active member of our ice-swimming sauna- club Reply @jasoncrump1886 @jasoncrump1886 1 year ago What do you guys think about c60? Reply @antoniettabonfigliovetere1195 @antoniettabonfigliovetere1195 3 months ago What about people with thalassemia? Reply @TheAustinDockery @TheAustinDockery 1 year ago Found it! Reply @celerywarrior6493 @celerywarrior6493 1 year ago 3 Tablespoons(30g) of Chia seeds = 4.9mg(60%) of iron Is that the sound of millions of smoothie making blenders slowly coming to a halt, that I hear? Reply @MsCorina222 @MsCorina222 1 year ago Can PLZ explain HGH and how we get more Reply @daddydustinmiller5150 @daddydustinmiller5150 1 year ago Subscribed before 1.2 seconds in to the Ad. 1 Reply @MsCorina222 @MsCorina222 1 year ago So what Solution for more energy?? Reply @chrishenkel2194 @chrishenkel2194 1 year ago please cover male pattern hairloss, l need a simple plan to stop and thicken my hair Reply @rameshnarkhede3681 @rameshnarkhede3681 2 months ago Can CKD BP THOIROID PERSON GO FOR HOT WATER THERAPY? Reply @nadirnft9712 @nadirnft9712 1 year ago Great thx David Sinclair Reply @axolotl8316 @axolotl8316 1 year ago 9:58 David belike: Yeah!, I am just a highschool biology teacher Reply @xenosonic @xenosonic 1 year ago Really annoying that the sponsors that are recommended are not available, or very limited to Australians. There is a whole world outside the US, ya know.... Reply @joeanna1100 @joeanna1100 1 year ago yes I'm going back to episode one it's on my list ...after that a makeup video Reply @joeanna1100 @joeanna1100 1 year ago hi forgot to ask how much metformin should we take if were not diabetic but want the health benefits is it 500 mg a day .thankyou Reply 1 reply @evelynok833 @evelynok833 1 year ago (Ignore this) Being cold: 58:00 Reply @adamloepker8057 @adamloepker8057 8 months ago (edited) The title feels slightly misleading in forecasting the material. Still a great watch though Reply @mirrameez10 @mirrameez10 1 year ago Thanku thanku both people 1 Reply @sumisharaina9530 @sumisharaina9530 1 year ago What about women supplementing with Iron while breast feeding? Reply @robertsmith1280 @robertsmith1280 1 year ago How do you have athletic greens every morning if you don’t have breakfast? Reply @pjb9617 @pjb9617 1 year ago Totally pernicious!!! Reply @christopherschwab3934 @christopherschwab3934 1 year ago Hyperbaric chambers eh? I always knew Dragon Ball Z was onto something! (Hyperbolic time chamber) Reply @billytoker1 @billytoker1 1 year ago Great podcast! Just a quick question for David.. have you ever had a facelift? Your eyes are looking quite stretched compared to photos when you were younger.. Reply @thomasdemayo4043 @thomasdemayo4043 1 year ago It really doesn’t matter what you do your gonna die one way or another maybe you can prolong life till 100 years of age if your lucky but who care when your that old you barley get around anymore for me I’ll stick to my high protein diet to build lean muscle mass if I can make it till 80 good enough for me doesn’t matter what you do you will die we r not god we all have and expiration date no way around that so enjoy life enjoy good healthy diets and workout as much as possible Reply 1 reply @MsCaterific @MsCaterific 1 year ago 💛 Reply @richardreed9166 @richardreed9166 1 year ago No one likes cold showers, channel your inner Wim Hof and get in that cold shower! Reply @MrEtc31265 @MrEtc31265 1 year ago Thoughts on Ozone Therapy? Thanks Reply @NB-lx6gz @NB-lx6gz 1 year ago I have a sitting down job. Damn. I don't have the means to invest in a stand up desk but I'll make sure to just stand instead of sitting down Reply @jaynemcguire @jaynemcguire 1 year ago Are the Athletic Greens Organic? Reply @heikl2132 @heikl2132 1 year ago Why do I need a hyperbaric chamber? Couldn’t we use a mask and hyper oxygenate the person that way? Reply @leavroc3491 @leavroc3491 1 year ago Yo i have this thought but can't you build up your heart ability to process unhealthy fats and eliminating toxic waste, but don't eat junk foot all at once, instead eat it at moderation and not very often. Reply @adityatiwari306 @adityatiwari306 1 year ago You said to not eat red meat, but can we eat fish, chicken etc? 2 Reply @citroneta @citroneta 1 year ago Wait, so Athletic Greens don’t cut your fast short???? Reply @prisar @prisar 1 year ago I wonder how anemic people should deal with free radicals 1 Reply @troelsthgersen178 @troelsthgersen178 1 year ago Doesn't Athletic Greens break a fast? 1 Reply @nimskai4264 @nimskai4264 1 year ago when you say iron do you also mean Zinc? Reply @esramala78 @esramala78 1 year ago I found you by watching Andrew HUBERMAN 💕 Reply @faisalg6654 @faisalg6654 1 year ago Man loves to trademark everything 1 Reply @Havie @Havie 1 year ago You said you don’t eat breakfast or lunch , but your ad for athletic greens says you have it in the morning? No calories in AG1? Reply @quarantees8736 @quarantees8736 1 year ago Can I buy a senescent cell blood test? Reply @quantumflux000 @quantumflux000 11 months ago ♥♥♥ Reply @pawepeczalski1526 @pawepeczalski1526 1 year ago Why wasn't this live : ( Reply @anmayo917 @anmayo917 2 weeks ago David buy water filled dumbbells for traveling :) Reply @jb318 @jb318 1 year ago I have to know how much Dr. Sinclair deadlifts!! Do tell!! Reply @devtestdevtest9014 @devtestdevtest9014 1 year ago Great 1 Reply @donotmissDutch @donotmissDutch 1 year ago 😇 Reply @richardpace8496 @richardpace8496 10 months ago Should I plan to die at 85 or 90 yrs. Or not? Reply @swamphawk6227 @swamphawk6227 1 year ago "Free radicals" in portland oregon. haha, I love it. Based. Reply @jungletheme2094 @jungletheme2094 1 year ago You guys can do bead bracelets as merch ahhaha Reply @jsprowse @jsprowse 1 year ago "I'll burn 10." Nice. Reply @zephyrahir8756 @zephyrahir8756 1 year ago What about old parents make a baby ? On longevity !!! 1 Reply @alexanderboyd7925 @alexanderboyd7925 1 year ago Should you eat less if you’re in youre 70s? 1 Reply @anonperson3972 @anonperson3972 1 year ago So 20 minutes pushing and dragging a heavy sled, get in an infrared sauna, do wim hoff breathing in the sauna. Get out, jump in a cold shower? Reply @SantassMamadas @SantassMamadas 1 year ago 20 thousand steps a day. Reply @7Clemencia @7Clemencia 10 months ago The Bible and The S.O.P. Gave us these instructions and even more …on how we can take care our bodies as a SDA people from more that 160 years ago. Longevity and vitality are the result of observing God’s laws of nature that rule the mind ,body ,soul and even the whole universe. They are unchangeable . We can’t separate them as men think they can. Nothing in God’s creation is isolated. True Education is the harmonious development of the physical, mental,emotional and espiritual faculties of the human being. Science without acknowledging Our creator Elohim (Father, Jesus Christ and The Holy Spirit) as the source of every knowledge is nonsense. He is the Alpha and The Omega the Beginning and the End , the First and the Last. Evolution is just a theory. Reply @lover7235 @lover7235 1 year ago are you also laughing at these guys while discussing sex-exercising?)) Reply @gropro4618 @gropro4618 1 year ago What does David think of vaccine? Just curius Reply @KYASEHM @KYASEHM 1 year ago How do we turned on the production of NAD? Reply @anglachris5564 @anglachris5564 1 year ago GREATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT Reply @broncos915 @broncos915 1 year ago David Sinclair CLIPS 🤞🏼💎😊 Reply @philipgeorgiev @philipgeorgiev 1 year ago this information free wow ! I ate cake today ... Reply @marknasia5293 @marknasia5293 2 weeks ago so @38:56 you are saying i can activate “sirtuin 69?” ok, now i want to live longer. Reply @japalaciosg1 @japalaciosg1 1 year ago How about a little bit of CO2 from time to time, Dr. Sinclair? Reply @phillipsnow4689 @phillipsnow4689 1 year ago Is it just me, or does the profile photo look a lot like Huberman's? 1 Reply @johnflood6718 @johnflood6718 1 year ago Dr. Sinclair says he isnt eating breakfast or lunch, is that with no snacks or smoothies/ protein shakes ? Reply @connorl5868 @connorl5868 1 year ago 35:55 My BMW will last forever *after 11 years 450.000 km - Next stop 1.000.000 *but there is a secret ... Graf video, btw Reply @idontcare4490 @idontcare4490 2 months ago How much iron is too much? You need to define levels. Don’t just say low levels are best. Reply @robertahenry8212 @robertahenry8212 1 year ago you might perceive that David S is it but pay attention to the side kick Reply @joeanna1100 @joeanna1100 1 year ago Hi can you try to make things simple so we can all understand thankyou Reply @CreativeTrixART @CreativeTrixART 1 year ago Dry sauna or wet sauna? Reply @anthony212459 @anthony212459 1 year ago (edited) So this guy says no protein?so let me guess exercise with no protien? Reply @lindahebb4832 @lindahebb4832 1 year ago Does any have any recommendations of affordable quality sauna blankets. Price range $200 to$ 299. Thank you Reply @wythra5183 @wythra5183 1 year ago Hey... you called out my town in Oregon. Cheers. Reply @356h7 @356h7 1 year ago there is good healthy information here, but also some disturbing unhealthy ones. drugs and animal torture must be stopped, and the point that by doing his ways we continue to live in this society on earth the same as we done for a long time now. we dont change our world and how we live in it that cause the short lives and unhealthy bodies we have now. we already have a low natural life, we are artificially kept alive way beyond when we should have died and do not take any consequences of our actions. Reply @blackspirit808 @blackspirit808 1 year ago 4 steps? count me in Reply @smartwater598 @smartwater598 1 year ago Wtf this guy also did a video where exercise ages us fast so we should exercise now he’s telling us to exercise? 1 Reply @MsEarth67 @MsEarth67 1 year ago Talk about Cartilage Reply @PeskyDaMan @PeskyDaMan 1 year ago Fuck please find a new co host this guy is brutal. Reply @sandrastrabeikaite7385 @sandrastrabeikaite7385 1 year ago This chanel so similar to what Hubermans lab looks like and even sound.. 1 Reply 1 reply @robinveerman678 @robinveerman678 8 months ago €2.49 Bedankt Reply @patriciacell3303 @patriciacell3303 1 year ago I'm your #1 fan Reply @ohgee8804 @ohgee8804 6 months ago Hello Dr, may I pm or email please? Reply @Hannhbanana @Hannhbanana 7 months ago (edited) 26:04 Time stamp 1 Reply @erwinrogers9470 @erwinrogers9470 1 year ago Yes 🔥 Reply @robertahenry8212 @robertahenry8212 1 year ago try going out in the ocean, it is very cold Reply @MrYoubet @MrYoubet 1 year ago AND YES CO CONSPIRATOR IS PROBABLEY CLOSER TO THE TRUTH Reply @ralphchapman565 @ralphchapman565 1 year ago You just said you don’t eat during the day and then advertised athletic greens which you have in the morning!!! Reply @stevenj6421 @stevenj6421 1 year ago David...CHANGE THE BACKGROUND please!! Also you seem different (worse) in your podcast as compared as other podcasts you have been... maybe because you seem t-shirt laid back 😅 2 Reply @usaintltrade @usaintltrade 1 month ago 🧬 1 Reply @MrBeckenhimself @MrBeckenhimself 4 months ago (edited) So if David Sinclair lift weights every day almost how is he gonna build any muscle without protein? Even IF we don't need as much as gym bros will have us believe, we still need protein to build muscle it won't happen without it. Yet he said before he eats a low protein diet. Which would absolutely crash his recovery. That makes me think. Because protein will increase mTOR but glucose that spikes inculin will ALSO increase mTOR. Yet the fact still remains. Protein is NEEDED to build muscle but it increases mTOR which is bad. So then what? Another thing is that exercise in itself will activate mTOR. So too little mTOR is bad for us, and too much is terrible. So there needs to be periods of both. A balance of both that leads to healthy aging and no this is not a guess. It's a scientific fact. Reply @jsaaiman @jsaaiman 1 year ago Damn called us Oregonians out! Reply @MissJete21 @MissJete21 5 months ago Why exactly hydrogen peroxide is bad? Because some people say it’s good and helpful. I am confused! 🤷🏼‍♀️🤷🏼‍♀️🤷🏼‍♀️🤷🏼‍♀️ Reply @viberoom-tj @viberoom-tj 1 year ago Nice Reply @edrock4605 @edrock4605 1 year ago What about laughing. A good belly laugh. Reply @childfree_cjw @childfree_cjw 1 year ago 饭后万步走，活到九十九😀😀😀 Reply @remorxromo2923 @remorxromo2923 1 year ago You don't eat atleathic greens every morning or do because I am confused. Reply @raniamohamed9848 @raniamohamed9848 1 year ago (edited) Too much is harmful, eventually we will die with all hard work goes for waste, let’s not exaggerate on increasing life span rather live healthy, and live your life without worrying of ageing, worrying only will lead you to ageing, for believer that believe on creator, no science will reverse ageing mayb slow ageing, let’s not turn to zombies here Reply @wefsux @wefsux 1 year ago I can't get the athletic greens code to work Reply @thepopeisdope559 @thepopeisdope559 1 year ago Didn't sit through whole podcast why low Iron levels ? Reply @krzysztofkrupa6624 @krzysztofkrupa6624 1 year ago min 38: windsurfing & sex, yes ! Reply @advertiserfriendlyusername5362 @advertiserfriendlyusername5362 1 year ago Anyone else got NAMPT flashbacks? Reply @bostaurus1 @bostaurus1 1 year ago I learned nothing new. Reply @tealatata @tealatata 1 year ago wieght training give you more mitochondria Reply @soundtenement7993 @soundtenement7993 1 year ago A build in Steam showers. Reply @timbo8366 @timbo8366 1 year ago 5 minutes? So we absolutely have to include foreplay? Reply @panoshadgipavli8282 @panoshadgipavli8282 1 year ago what about the wim hof method Reply @truth3404 @truth3404 1 year ago Is it me or is everyone of these health guru people always promoting some kind of product. Reply @fredwinslow744 @fredwinslow744 1 year ago He’s steadily losing credibility. Telling us we can skip the 150 k waiting line is so ridiculously disingenuous and meant to stimulate action not inform .. scarcity and special treatment approaches are unnecessary. Elon musk doesn’t Tell people why they need to buy or even advertise Dr Sinclairs word was good enough This is getting very much like Dr Oz Maybe that’s the goal ? 1 Reply @bottomphishing7377 @bottomphishing7377 6 months ago World health organization reference lost me... Reply @ZohnnyBravo @ZohnnyBravo 1 year ago (edited) hahaha What a Bozo! He suggests paying for hyperbaric chamber where you would watch tv while mimicing exercise, and he finds cold showers unpleasant!!! 1 Reply @kasiabiniek6701 @kasiabiniek6701 1 year ago :) 1 Reply @JeffAbbott60 @JeffAbbott60 1 year ago Also supplements with iron is the wrong kind of iron! Which is bad! Reply @riddlescom @riddlescom 1 year ago (edited) I know alot of people that act like worms and rats . So they are going to live longer . I'm always under stress . I'm suffering. So I guess I'm going to live . I was thinking I want to live happy . But apparently if your happy you die. Suffer and live . I'm not really buying it. Our ancestors died at 30 years old . They were stressed . I think the 100 year olds alive today. Are not doing anything special. They just have good Gene and lucky. I'm ok at 65. But no matter what I do I'll be dead at 85. So I should just have fun now while I can . Reply @marz2629 @marz2629 1 year ago Did someone say hair growth?!?! Reply @anthony212459 @anthony212459 1 year ago I knew he dyed his hair! Reply @ayox @ayox 1 year ago joe rogan is busting so hard somewhere rn 1 Reply @chromashift @chromashift 1 year ago hmmm.... saying that lifting was comparable to trt? interesting indeed; Reply @ZlyJaszczomp @ZlyJaszczomp 1 year ago Can I go to sauna everyday ? Reply @user-wi7xo5ry4t @user-wi7xo5ry4t 1 year ago (edited) Can I buy Athletic Greens in Korea? Reply @beatakazanecka8798 @beatakazanecka8798 1 year ago @David, are you really drinking Athletic greens every morning? ;) 2 Reply 2 replies @lordoft2410 @lordoft2410 1 year ago Love 1 Reply @Babyy_girl @Babyy_girl 1 year ago 1:11:36 Reply @stayfit57 @stayfit57 1 year ago I bet the new thing is med beds Reply @portiajoo7247 @portiajoo7247 1 year ago Is that Fred Durst?! ;) Reply @tumadre69727 @tumadre69727 1 year ago Lol thats why you're not gray at fifty, you color your hair. Reply @youtubeiscruel3946 @youtubeiscruel3946 1 year ago Athletic greens lmao 1 Reply @lesahardman9914 @lesahardman9914 1 year ago Im a truck driver... sitting is the job... sigh... Reply @brodie_lee7904 @brodie_lee7904 1 year ago Is this man not completely ripping off Andrew Huberman??? Down to the thumbnail and intro 1 Reply @rooooooby @rooooooby 1 year ago I can do four steps haha Reply @jamesfrith9869 @jamesfrith9869 1 year ago For the Alg boost Reply @KAI5ERCHIEF @KAI5ERCHIEF 1 year ago why does inside tracker have so many bad reviews? Reply @ambishuhs @ambishuhs 11 months ago Can you sport to much? Reply @gabriella6299 @gabriella6299 1 year ago This guys thumbnails look too much like Andrew Hubermans. Reply @tubestick00 @tubestick00 1 year ago Is this guy from New Zealand originally? Reply 1 reply @somethought @somethought 1 year ago 5 minute sex???!! My average is 2 hours. A woman’s body takes about 20 minutes to even fully warm up. Who the F is having 5 minute sex???? That’s not even worth having! thats horrific. What man is THAT selfish??!!! Reply @barbaraglover4451 @barbaraglover4451 1 year ago greeting gentlemen and welcome Reply @cholakicha @cholakicha 1 year ago (edited) 57:30 Reply @boneclinkz2916 @boneclinkz2916 1 year ago May I request less interruption while he is explaining. Reply @davidsaak2705 @davidsaak2705 1 year ago Great podcast but would be better if you cut down on selling insidetracker. You overdo it and sound like a Honda seller 1 Reply @onlyprivate6004 @onlyprivate6004 1 year ago What about women ...? testosterone ? 😂 Reply @fredwinslow744 @fredwinslow744 1 year ago (edited) She he said lovely I was certain he was talking about his wife or a lady guest. It’s perfectly unisex. But is Dr Sinclair gay? 1 Reply @LeMez4845 @LeMez4845 7 months ago 59:12 Reply @lindafox3619 @lindafox3619 1 year ago DYEING YOUR HAIR !!! NOT GETTING RID OF GRAY ???? OK THEN ... Reply @eddylauterback1312 @eddylauterback1312 1 year ago Please find a smarter interviewer! Reply @innosanto @innosanto 4 months ago So stressed cows and chickens that are all together in little space are mosmre healthy ? Becauee you want stressed food? Reply @billdolar9995 @billdolar9995 1 year ago yoda mice vs homo florensis? Reply @edwardmcguire3801 @edwardmcguire3801 1 year ago Get to the point Reply @shanebplante @shanebplante 6 months ago David I admire your work , but lying to people is not admirable . I don’t care if you dye your hair . You didn’t “ get bored during Covid and dye your hair a lighter color “ what happened is your natural color hair going grey wouldn’t be able to be covered correctly by your nature color hair dye so now you dye your hair . Just be honest because I easily Sensed your lie . Reply @alessandrodimeo6570 @alessandrodimeo6570 10 months ago (edited) You have been watching a 1.11h video. Now get off your butts! Reply @IceStationZebraAssociates @IceStationZebraAssociates 1 year ago 1:00:14 freakn marriage... Reply @tombryan9531 @tombryan9531 1 year ago What are you missing? Matching turquoise earrings? Reply @water8048 @water8048 1 year ago david has a very smug look on his face 1 Reply 1 reply @user-hl3pv7ct1w @user-hl3pv7ct1w 1 year ago Why does my dude end every sentence with the most annoying whispers in the world ? 🤔 impressively annoying. 👏🏻 Reply @brookmachatte @brookmachatte 1 year ago (edited) Shoutout Eugene, OR lol 1 Reply @TJ_Gonser @TJ_Gonser 1 year ago Lesss gooooo Reply @m5p944 @m5p944 1 year ago Something artificial about this thing Reply @tessacyclone6329 @tessacyclone6329 1 year ago Not eating is so unrealistic as your brain needs fuel too , I'd rather be able to THINK and have attention for other things and for people rather than the organism into defense mode . You havent proved that skipping meals is antiaging its just a theory, silly quack ideas. Reply @rredding @rredding 1 year ago I don't know why... But this guy irritates me to level I throw the entire stuff out of the window. Not 4 me... Reply @williamharvey4732 @williamharvey4732 1 year ago Can you hush up and leave HIM ! speak. Shhhhhh. Reply @capri2673 @capri2673 1 year ago Have you had botox? Reply @anthonytoo5260 @anthonytoo5260 1 month ago Yeah baby! Reply @kaptainh5538 @kaptainh5538 1 year ago Lift Weights Reply @brianjohnston9115 @brianjohnston9115 4 months ago "believLBLE experience" yet no wif hof. same lipstick, dif lipstick here. Reply @jrashad @jrashad 1 year ago portland kekw 1 Reply @sanatsrivastava2814 @sanatsrivastava2814 1 year ago Hi, Dr. Sinclair. Quit replicating Huberman. Thanks. Sincerely, Everyone. 2 Reply @marmaladesunrise @marmaladesunrise 1 year ago David, you have a horrifying look on your face. Scary. Reply @erikmorales17 @erikmorales17 1 year ago 121k Reply @christinamariehicks1078 @christinamariehicks1078 1 year ago Dont use statefarm ins ..jack clark mike maloney ..reorganized church christ ..leanna lewis spitler ..odin ill. Playing json tv ..gee .. Reply @remymay3632 @remymay3632 1 year ago Wrong podcast, I know.. Reply @TheKickBeck @TheKickBeck 1 year ago Prophet Muhammad told the human race to eat less, less meat, intermediate fast and many more. Reply @williamharvey4732 @williamharvey4732 1 year ago Raiders , wanna be, hat ? Really? Reply @christinamariehicks1078 @christinamariehicks1078 1 year ago Tammy street sands .. Reply @ryanleith3080 @ryanleith3080 1 year ago I’mo Reply @y.g.1313 @y.g.1313 1 year ago Sinclair- mostly junk, as usual.. Reply @mattz9440 @mattz9440 8 months ago Heme iron bad 1 Reply 1 reply @rinakundu7326 @rinakundu7326 1 year ago Fak Reply #4 Lifespan with Dr. David Sinclair NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | David Sinclair Download 677,555 views Jan 26, 2022 Podcast Episodes In this week’s episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share the latest experimental and clinical data for NAD boosters (these being NR, NMN, NAD IV drips and shots), resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine. Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. Known mechanisms, limitations, and/or side effects associated with these molecules are additionally highlighted. Correction and clarification: At time point 1:07:37, Dr. Sinclair says he takes 1 gram of Spermidine, but the active ingredient in the capsules is 1-2 milligrams. We apologize for the confusion. #DavidSinclair #Longevity #Lifespan Thank you to our sponsors: Levels - https://levels.link/sinclair InsideTracker - https://insidetracker.com/sinclair Athletic Greens - https://athleticgreens.com/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsincla... Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclai... Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante Timestamps: 00:00:00 Kicking Off Episode Four: Longevity Molecules 00:02:15 Thanking the Sponsors 00:04:46 An Additional Boost Beyond Adversity Mimetics 00:05:52 Drugs vs. Supplements and Highlight Points 00:09:54 Longevity Molecules Target the Survival Circuit 00:11:33 NAD Boosters 00:13:32 Nicotinamide Riboside 00:21:26 Nicotinamide Mononucleotide 00:29:22 NAD Intravenous Drips 00:32:45 Bioavailability of NAD Boosters 00:33:40 NAD and Cancer 00:35:33 Resveratrol 00:42:26 Red Wine and The French Paradox 00:43:08 Fisetin and Quercetin 00:47:09 Rapamycin and Rapalogs 00:49:10 Spermidine 00:51:27 Metformin 01:00:27 Berberine 01:02:43 Dr. Sinclair’s Protocol for Longevity Molecules 01:08:51 Wrap-up and Next Week’s Episode: Interventions on the Cutting Edge 01:09:52 Options for Subscription and Support Links: The Sinclair Lab website: https://sinclair.hms.harvard.edu/ Nicotinamide riboside is well-tolerated in humans: https://go.nature.com/3G1blbb Nicotinamide riboside is a sirtuin-activator: https://bit.ly/3FUWWxa Mice treated with nicotinamide riboside are longer-lived: https://bit.ly/3KD5L2h Nicotinamide riboside protects mice against obesity: https://bit.ly/345E4hF An inflammatory signature is attenuated by nicotinamide riboside: https://bit.ly/3Aum78I Nicotinamide riboside, pterostilbene, and ALS: https://bit.ly/3nYdxK6 Nicotinamide mononucleotide combats diabetes in mice: https://bit.ly/3AwakXx Aging is slowed by nicotinamide mononucleotide: https://bit.ly/344jGgW Nicotinamide mononucleotide in prediabetic women: https://bit.ly/3H1vv6b NAD and cancer in mice: https://go.nature.com/32xl1wp Resveratrol protects mice against a high-calorie diet: https://go.nature.com/3G2pZyE Resveratrol in patients with type 2 diabetes: https://rsc.li/3Aupk8h Supplementing resveratrol in metabolic syndrome patients: https://bit.ly/3IE6C0Q Fisetin enhances longevity in mice: https://bit.ly/3o10hom Quercetin and fatty liver disease: https://bit.ly/3H4KWdF Dasatinib and quercetin decrease senescent cell burden: https://bit.ly/35pCHuY Mice fed rapamycin late in life live longer: https://go.nature.com/3F0yud3 Spermidine induces life extension and cardioprotection in mice: https://go.nature.com/3fXL5nn Spermidine and older subjects with cognitive decline: https://bit.ly/3IG0MMy Healthspan and lifespan in mice are improved by metformin: https://go.nature.com/3JSRZbs Metformin, age-related diseases, and mortality: https://bit.ly/3KG0iaS Targeting aging with metformin (TAME) trial: https://bit.ly/3eU9ABk Treating mice with berberine extends lifespan: https://bit.ly/3AwkO9l Lifespan in fruit flies is prolonged by berberine: https://bit.ly/3nYpwYt Berberine and metabolic disorders: https://bit.ly/3KUpwCC Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. Chapters View all Explore the podcast 8 episodes Podcast Episodes David Sinclair Podcasts David Sinclair 299K subscribers Videos About 1,566 Comments rongmaw lin Add a comment... @DavidSinclairPodcast Pinned by David Sinclair @DavidSinclairPodcast 1 year ago Correction and clarification: At time point 1:07:37, I said I take 1 gram of Spermidine, but the active ingredient in the capsules is 1-2 milligrams. I apologize for the confusion. 297 Reply 46 replies @davidm1411 @davidm1411 1 year ago The co host is great. He has a very effective way to be both a “layman” as he asks questions while at the same time, generally savvy on the topics. Also, I congratulate you both on not taking yourselves too seriously. We already get enough of that with certain scientists. 460 Reply 14 replies @apocryphalsubfusion @apocryphalsubfusion 1 year ago Thank you for another amazing podcast! The shows notes, the timestamps and the explanations were very digestible (pardon the pun). Seriously thank you David, Matthew, And the team at Harvard medical school working hard to bring us the best longevity science to date. I can't believe that this information is freely available for all of us 30 Reply @johnalbers8020 @johnalbers8020 1 year ago I am a physicist by education. I used to think the biology was an easy subject. Not any more. Listening to this very interesting podcast, I marvel at the complexity of biological systems. This podcast is very informative and easy to understand. I plan to use some of the supplements outlined in this podcast. Excellent 23 Reply 6 replies @lindawalker2092 @lindawalker2092 1 year ago Love this series of episodes. Very informative and hopeful for those of us in their 70s. Vanity would have driven my interest before, now it is quality of life. Especially cognitive function as I'm watching friends in their late 70s and 80s, mentally declining. Not all but so many. 26 Reply 1 reply @levondarratt787 @levondarratt787 1 year ago They are both great. And co-host - just the way he breaks things down - while being super educated as well. And stops things, when they get confusing. Then David re-iterates, and explains as needed. Those 2 are something else! 24 Reply 1 reply @mrLoftladder @mrLoftladder 1 year ago I'm taking a similar supplement regime myself and have been doing it for a couple of years now. 67 Y.O and feel more energetic and certainly fitter than any time since my early 50s. loving these podcasts learning so much from them, thank you. 14 Reply 1 reply @ashleyjwilliamshand @ashleyjwilliamshand 1 year ago (edited) I was so stoked when I saw you started this channel. Loved watching you as a guest on other podcasts, so this is a treat. Great job so far! 207 Reply 5 replies @boydhooper4080 @boydhooper4080 1 year ago Great that you go deep into dosage, timings and other details on the supplements. So frustrating when others don’t do that. 29 Reply @johnwilhelm @johnwilhelm 1 year ago Have been following David since the early Resveratrol days. Was super excited when this series started. Thank you for your continued efforts to expand our knowledge on this topic. You and Matt make a great duo and I hope this series continues beyond the current scope. 6 Reply 1 reply @bronwyndoyle1403 @bronwyndoyle1403 1 year ago Really looking forward to the Centennial podcast! brilliant podcast, you two are a great team! 16 Reply @r.davidyoung7242 @r.davidyoung7242 1 year ago (edited) Thank you! I appreciate your information and the sense of respect you seem to have for human kind and life in general. I wish both of you vibrant health and long life. 💚 I listened to your book on Audible. It's great. 7 Reply @sylvieasics6570 @sylvieasics6570 1 month ago I really like the chat/questions format with this super knowledgeable co-host that makes it so much more valuable than with a real layman! Thanks both 1 Reply @redpilllense7125 @redpilllense7125 1 year ago Thank you, Dr. Sinclair! I look forward so much to this podcast series. You truly are helping me 🙂 57 Reply @rosiesmallshaw @rosiesmallshaw 1 year ago Love your podcasts! The synergy is always courteous and encouraging. Keep up the great work 👏🏼👏🏼👏🏼 10 Reply 1 reply @paulwn2023 @paulwn2023 1 year ago Really loving the podcast series. Great refresher for the book. Finding some of the supplements in Australia is harder than the US. Any recommended labs? 2 Reply @daventhegreat @daventhegreat 1 year ago (edited) Thanks David & Matthew absolutely amazing series. I have a very important request: Can you do an episode on what molecules/drugs are safe if we already have cancer... some of the common cancers .. prostrate, breast, bowel, lung cancer .... that would b gr8.... if that's possible given the huge diversity that's present in these disease processes & stages. Are there any universals for particular molecules or types of cancer? Etc 6 Reply @partakith3673 @partakith3673 1 year ago I truly appreciate everything you are working toward, even if much of it you have to hint at in over 40 hours of videos :). Who doesn't love a puzzle? You bring the thoughts and ideals of a future unlike any I would have thought to see in our lifetime. Thank you! Reply @tomwawersich809 @tomwawersich809 1 year ago Love the podcast- great episode! I have heard I should be taking TMG with NMN - would love to hear if you do this. Thanks again for your work in the area of aging! 6 Reply @thatchessguy7072 @thatchessguy7072 1 year ago Hi David! I’ve been implementing what you suggest (I haven’t yet implemented supplements yet) and I feel a lot better! One of the things I’ve done that’s helped a lot is actually something you haven’t mentioned in the podcast yet. I took a food sensitivity test and cut out the foods that tested positive for sensitivities. Milk was apparently causing me muscle and joint inflammation as well as stomach problems. 39 Reply 5 replies @futonsjapan6365 @futonsjapan6365 1 year ago Great stuff. Hopefully we can get a list of blood test to take and how often to measure effectiveness and if it causes any problems. Apart from the physical or mental impact 4 Reply @judipapendick2460 @judipapendick2460 1 year ago This is all so very fascinating! Thank you for speaking to the public directly without the media filter! You are both of a lovely generous spirit 4 Reply @juiianadebeers8230 @juiianadebeers8230 4 months ago I just finished your incredible book Lifespan—for the third time. First reading was an audio version and I stopped every hour to cry hard. I read a lot for a leadership program that I teach for the Air Force and thank you btw for mentioning USA air supremacy. LITERALLY THE MOST INCREDIBLE INFORMATION!!!! I tried to relay it all to my own adult professional child and her husband and sounded like a blithering idiot bc I get so emotional. I am thrilled to find this podcast so I do not have to try. Your optimism is a leadership trait; you’re an educator, not merely a scientist. Your book’s messages were mostly about longevity, but also part existential, part environmental, and part economical. As a teacher myself a huge obstacle is keeping my students and coachees happy about humanity. I am as wound up at the end of your book as I am at the beginning. Thank you for your genius and your optimism. Reply @uberandreman @uberandreman 1 year ago Second comment: I want to add that I am following much of your protocol and I have so much energy it is incredible! I am relatively young (33), but have been dealing with fatigue for a long time. Particularly the day after intense exercise (BJJ). I have trouble focusing and getting through the day even with heavily optimized sleep. I am currently alternating between 16 and 22 hour fasts. When I do eat, it is mostly a low protein, high carb, plant based food (with some junk thrown in because I'm human and still working on things). I am taking NMN, resveratrol and Metformin. And I feel like a million bucks! I am recovering well, focused, creativity is up. I am honestly shocked and hope this is able to sustain itself for the next few months (I do not plan on doing all of this indefinitely). 18 Reply 10 replies @88Jenpal @88Jenpal 1 year ago Thanks for this podcast, I appreciate all your work and I been trying to follow your regimen. I wish that you could tell or advise us which you think is the best choice NMN supplements. I been paying a lot for it and still not sure if they are true to their advertising or I pick the right one. 30 Reply @donotageteam451 @donotageteam451 1 year ago Another excellent podcast David - we love your work! 76 Reply 7 replies @rapamycinnews @rapamycinnews 1 year ago Great to see David covering rapamycin a bit more than in the past. 9 Reply @jeremydavidevans9743 @jeremydavidevans9743 1 year ago (edited) Your partner contributes a lot to the interview! Excellent match, glad to see this information presented in an accessible way. 2 Reply @rhognaldmcdognalds1806 @rhognaldmcdognalds1806 1 year ago Thanks for providing health and wellness on a massive scale! Reply @mykolashcherbynin762 @mykolashcherbynin762 1 year ago (edited) Thank you David for starting this podcast and popularizing science. Could you give some information or make an Episode about such substances as curcumin, grape seed extract. It was told about them in the books of such a well-knows scientists as Ray Kurzweil, David Servan-Schreiber, T. Colin Campbell and Thomas M. Campbell etc. but it would be interesting to hear your opinion and recommendation regarding the actual scientific information about this substances. Reply @puppygirlfm1483 @puppygirlfm1483 1 year ago David, thank you for sharing your knowledge to help others! Question about Berberine- when should I take it? At night, the same as when you take Metformin? 14 Reply @katharineofarrogant7805 @katharineofarrogant7805 1 year ago (edited) Highlight of my week. As soon as I listened to these I started OMAD, changed my diet and exercise routine. I've sent this to all my friends and family. Pure gold! 16 Reply 2 replies @mayrakennedy6200 @mayrakennedy6200 1 year ago amazing episode! loaded with so much information. question about a supplement called,True Niagen. I took it for about 3 months but didn't notice any differences in my skin or performance. What time frame do you recommend taking a supplement for anti-aging? 6 month? a year? Thank you :) 2 Reply @estoy1732 @estoy1732 5 months ago Hi doctor. Thank you for your intellect! Thank you for existing ! Thank you for posting all this content. It’s so rich with knowledge. Thank you for your work. Reply @bellehamilton3395 @bellehamilton3395 1 year ago It's difficult to evaluate something with no visible consequences, but the research points to a positive outcome. It's probably best to utilize while you're under physical duress. This product has met my expectations in that it has made me feel more energetic in the morning and throughout the day since I started using it. I'll keep taking Vitruvin Health Anti-aging supplement since it keeps me energetic throughout the day. 1 Reply @winbalingit8502 @winbalingit8502 1 year ago I saw Dr. Sinclair on a podcast giving a lecture on Resveratrol, it was for a wine convention, everyone, including Dr. Sinclair was drinking red wine!! The lecture was very educational and entertaining!!🤩👍🏽 8 Reply @su6a12m3lon @su6a12m3lon 1 year ago Hi. There's a lot of literature on NMN improving fertility but not much is said about what happens after conception is achieved. Is it safe for pregnant(or breastfeeding) women to continue supplementing with anti-aging supplements, specifically NMN? Thanks for this extremely educational series! 1 Reply 1 reply @nickyo56 @nickyo56 1 year ago (edited) I aged a full week waiting for this podcast 🙃 669 Reply 33 replies @BurtWalker100 @BurtWalker100 1 year ago David Sinclair and his Co author have produced one of the greatest blog for those managing their health. Bravo. Reply @spirtfire6004 @spirtfire6004 1 year ago What are your thoughts on apigenin? Especially in a post menopausal female on estrogen replacement—thank you for this terrific podcast and lending us your knowledge 18 Reply @jenneferwillard7758 @jenneferwillard7758 1 year ago I’m obsessed. I’m so excited about this research. I’m 50yo. I haven’t had any living parents, grandparents etc in over 10 years. I’m determined to change this for my family! 23 Reply 4 replies @captainpike2468 @captainpike2468 1 year ago Important to emphasize ‘the threshold level’ as David discussed in his interview with Rhonda Patrick PhD , the ‘natural clearing process ‘ of the body that will eliminate NMN supplements , Resveratrol from the body - and David’s idea of ‘pulsing ‘ these supplements every other day , then fasting and exercising 7 Reply 1 reply @yummimaus @yummimaus 1 year ago Thank u! Really appreciate you being so direct about how to supplement these ingredients. And David you look amazing for ur age and that make me believe you… and love the fact that u do so much in your own labs… instead of reading from others’ report only! 2 Reply @thomasbiom @thomasbiom 1 year ago I was hoping that you would discuss Methylation concerns and the use of TMG to mitigate. Also, I find the piece that’s often missing from Such discussions is for pregnant & breastfeeding mothers. 41 Reply 1 reply @es1653 @es1653 1 year ago A fantastic podcast but I haven't seen these items for sale in Canada. Please keep up the incredibly fantabulous work. I want to go jogging at 120!! 1 Reply @brianoshea4411 @brianoshea4411 1 year ago Hi David, bought your book, made a massive difference to us. Thanks so much. EU suppliers mostly use the same NMM origin. A UK supplier argues that it must be produced using enzymes. Is it worth paying a lot more for the UK process? Reply @christianl.lorenzana8095 @christianl.lorenzana8095 9 months ago Thank you for sharing your knowledge based on facts, sir Sinclair. Reply @marwamite4024 @marwamite4024 1 year ago Hi! Thanks for all your work - When you were on Huberman's podcast, you briefly mentioned that taking Resveratrol on alternating days produced better results in mice based on a specific study, and that the beneficial effects could even be mitigated by daily intake. But I've also heard you talk about it being in your daily stack, as you've mentioned here. Could you elaborate/clarify whether you think a daily or alternating intake could produce a significant difference in potential effectiveness of Resveratrol ? 97 Reply 7 replies @alexandrabavcevic9643 @alexandrabavcevic9643 1 year ago Thank you Dr. Sinclair. I really appreciate the information on this channel. 1 Reply @HannahIm @HannahIm 1 year ago (edited) Question about supplementation that I hope can be addressed in season two! As I understand NAD levels steadily decline as we age as do levels of other things such as CoQ10. That seems to imply that the older a person is physiologically, the more NMN/ND they would need to take to restore their levels to youthful numbers. Also, as I understand, NMN or NM delays/reverses aging at least in mice and probably humans. So. . . as I 41 years old, could I reasonable expect that I could start now with a lower level of supplementation, say 500 grams a day, and if I keep taking it for 10 years, I would theoretically not have aged as much as thus perhaps not need to supplement as aggressively as a 51 year old who had never done anything for anti-aging. I get that there are many factors involved, but all things being equal, is that a reasonable supposition? 3 Reply @Grumphhh @Grumphhh 1 year ago Thanks a lot for this podcast. A question: Is there a difference between Nicotinamide Riboside Chloride and Nicotinamide Riboside? Reply @howardlui9943 @howardlui9943 1 year ago Fantastic co host! Great questions .. great balance of talking and allowing David sinclair to speak! Reply @garretjaxen69 @garretjaxen69 7 months ago (edited) Hi David. I apply the frequencies of red-light and Infrared light directly to my hologram. I get a huge boost of energy, say 35% to 50% and my facial skin just glows. Would you consider this dangerous, can the cells maintain this level long term? Love your work! Reply @hotchicsf @hotchicsf 1 year ago (edited) Thank you for all your hard work Dr. Sinclair. I listened to your channel and then went out and bought resveratrol and yogurt. I've been taking it for a few days now (along with NMN and metformin) and I'm feeling great. But then I get a video on my feed from Dr Brad Stanfield saying that resveratrol is harmful to humans. Now I'm confused. Still taking the resveratrol with my yogurt, but I'm a little worried. Will my daily metformin dosages overcome any issues with resveratrol? 6 Reply @Thebusysuperhuman @Thebusysuperhuman 1 year ago Thanks for this - I love the way you and Matt interact - All scientists need a Matt to help explain to lay people 2 Reply @user-ud4do1hj5t @user-ud4do1hj5t 1 year ago Dr. Sinclair, hope you will discuss how NMN affects kidneys. Kidneys are crucial to life but are not discussed often. Thank you! 44 Reply 1 reply @GuillermoTorresDesign @GuillermoTorresDesign 1 year ago Thanks for the podcast! My request for the future is to do a deeper dive on some of the markers. I’ve been very frustrated in particular about VO2MAX. But would be good to understand the ones from Inside Tracker as well. 2 Reply 1 reply @philc6331 @philc6331 1 year ago Id been waiting for this one . Thank you so much for these podcasts, keep them coming . 1 Reply @MarkT311 @MarkT311 1 year ago NMN and breast cancer - I realise this post is sometime after the episode, but given it's importance to me (and that I'm Australian!) I hope you will respond. We started taking NMN and resveratrol 6 weeks ago, after listening to your podcasts. A week or two later my wife (aged 50) was diagnosed with an aggressive form of breast cancer that was undetected in a mammogram 6 months prior. Her sister also died of breast cancer. I have read about, and heard you talk about in this episode a possible connection between NMN and cancer growth in mice predisposed to cancer. I appreciate the science on this is very uncertain, but on the balance of probabilities, if you were in my shoes, would you be suggesting your wife continue to take NMN, or stop? I suggested she stop soon after reading about this possible link, and is currently only taking resveratrol. 4 Reply 1 reply @AndresLaszloJr @AndresLaszloJr 1 year ago Very much enjoy your podcast. Thank you. If, approaching the last of my 20 hours of daily no-food, I fill my tummy up with something non-calorific (like water or husk), my hunger pangs will go away. My question is: As I make myself feel not hungry, what happens to the "body-believes-I-am-starving-and-switches-on-live-longer-effects?" Do the beneficial longevity "buckets" listen to my psychological hunger (and turn off): "He's not in starvation mood any longer," or physiological hunger (and stay on); "He is mistaken because, in reality, he is still in starvation mood? 2 Reply @cindyradison8324 @cindyradison8324 1 year ago My mom is 68 and never feeling old. Her retirement has been more fruitful and productive. My mom doesn’t have any age-linked issues even the minor ones. She still hikes with her friends. My grandma is 85, and still very strong and mentally alert. No medical issues except mild joint pains that come occasionally. They’re both very healthy and happy. Still can participate long family travels and visit one country a year. Thanks to NMN supplement by Vitruvin Nutrition. Age is just a number! Reply @govendrag @govendrag 1 year ago Thanks for the very informative podcast and also talking about studies which show harmful effects of some of the supplements. For folks outside US, where we don't have inside tracker, can you pls suggest periodic blood tests we can do to ensure that the supplements aren't having a harmful effect on our bodies (including nmn potentially expediting cancer cell growth) ? It will be great information and people elsewhere can keep a tab on their health with these supplements. 32 Reply 3 replies @SuncloudMashups @SuncloudMashups 1 year ago Thank you for another great episode. I'm really a fan of these. I have a question about NAD boosters - do you think that supplementing with something like NMN could potentially suppress the bodies natural production of NAD in the long or short term? 46 Reply 4 replies @GodofStories @GodofStories 1 year ago Cohost is great! Matthew great job explaining and discussing the finer details! Bravo senor! Reply @jamescoates6849 @jamescoates6849 1 year ago Hi David. Have you found that adding NMN to your regimen has had a noticeable benefit on how you feel or how you can exercise? Thanks. Reply @paveldrobnych @paveldrobnych 1 year ago (edited) In recent studies they show that resveratrol/pterostilbene induce replicative stress - should we get concerned? Otherwise this is a truly super-star show, many thanks for doing this. 3 Reply @triciamedora9274 @triciamedora9274 1 year ago Lord David really does look younger and his Skin is glowing.. Gosh hopefully he will do a podcast in the near future regarding supplements that are effective and proven to be safe that we can consider using at this very moment . 2 Reply @natalieaxl804 @natalieaxl804 1 year ago Thank you Dr, David! I would love to be part of your study. Thank you for all the information you share with us 🙏🎊💕 4 Reply 1 reply @Panaphonics @Panaphonics 1 year ago Great discussion! Thank you. I'd like to know if there is a correlation between stressed vegetables having greater health benefits VS a stressed animal. I can imagine there is a whole different set of rules for an animal that has been penned up and fed a terrible diet, VS a plant being harassed by bugs, weather, fungi, virus, etc... Keep up the great work! 7 Reply 2 replies @mariamessina550 @mariamessina550 1 year ago Awesome information, thanks so much for sharing your knowledge 🙏🏻🙏🏻👏❤️ Reply @maecechota5076 @maecechota5076 9 months ago Thank you David. What I'm wondering is that I have an autoimmune digestive disorder. I'm on immunosuppressants. Is it OK to take NMN? I know it doesn't cause cancer, but it can fuel a tumor you already have. My doctors don't know the answer. What is your opinion? Thank you for everything you do! Reply @francischen3819 @francischen3819 1 year ago Thank you David - I am a huge fan of your work! 3 Reply @Bodzio1982 @Bodzio1982 1 year ago What you said about NAD levels and alcohol just proved that my supplements are working. I’m not a drinker but when occasionally I have some alcohol I feel very bad next day. Last week I had few too many drinks and the next day I was feeling pretty well. Still had little hangover but wasn’t sick. 2 Reply 2 replies @edwardpoppiti2258 @edwardpoppiti2258 1 year ago Hello, really liking the series so far. When talking carbohydrate there is a lot of talk about how many plants utilize certain chemicals to ward of predation, and that because of this they are harmful to humans and should be avoided, making the case for "primal"/keto. The question I have is: is it possible that these chemicals could actually be stimulating an "adversity" response and in fact be very beneficial to humans? 8 Reply 2 replies @paulofradiano4414 @paulofradiano4414 8 months ago Hi David, you're awesome! Congrats for the Longevity person of the year award! Question... do you prefer Fisetin or Quercetin? Which one do you think to be safer for liver/kidneys? Reply @wolfpack8193 @wolfpack8193 7 months ago Thank you so much. This information not only helpful to me but also to my parents and family. 🙏🙏🙏 Reply @pete8009 @pete8009 1 year ago The cancer issue with NMN and NAD was casually mentioned in this video. This is a big problem according to more recent research. For example, see Dr Brad Stanfield's video on why he stopped taking it and why he focuses on decreasing senescent cells instead (via fasting, etc.). He also takes fisetin and quercetin to reduce senescent cells, which coincidentally Dr. Sinclair now does as well (perhaps he's worried about cancer). Either way, use extreme caution here! 6 Reply @sbrooke1300 @sbrooke1300 10 months ago David, I would be very interested in a video documenting your father’s use of these longevity products and how he is doing. I am a woman in her late 70s and am interested in how older people are responding to these supplements . YouTube videos seem to be posted by middle age men and much younger women. It appears as more a vanity thing than someone seriously interested in longevity. 3 Reply @lucycooper55 @lucycooper55 1 year ago Just finished his book . I was glued the entire time. I know he’s working on another. Anyone know it’s approximate release? I can’t wait 🏋️‍♂️ 2 Reply @arnaldurbjornsson3638 @arnaldurbjornsson3638 1 year ago What quality content, been so eyeopening for me to read the book and listen in here. I literally feel when my mindset is that I'm getting younger, I in fact am. 15 Reply 1 reply @TugHillGuy @TugHillGuy 1 year ago I started taking NMN about 5 years ago after reading an article online from David Sinclair. I think I took it sublingually right off as I read that much more of it would reach my blood stream that way than simply swallowing it. A year or two ago the company I was buying my NMN from (Renue by Science) came out with liposomal products that allow a substantially higher portion of the product to get into your blood stream than their sublingual products. The liposomal process prevents NMN from being digested into NAM and the possible harmful effects that can have on your liver. 1 Reply @TylerEidt @TylerEidt 1 year ago Thanks for this informative video! Couple questions. If resveratrol works better when ingested with fats, would it be as effective to take with fish oil capsules as with the suggested yogurt or olive oil? Also, would taking Athletic Greens in the morning significantly break the fast if trying to skip breakfast? Thanks again! 9 Reply 1 reply @jeffmiddlebrook5251 @jeffmiddlebrook5251 1 year ago Agreed, a podcast on NCEs will be important. 2 Reply @BenHutchison @BenHutchison 7 months ago Resveratrol is copping some heat on the internets; would be good to see some discussion of why it's controversial in a future episode 1 Reply @Dimer95 @Dimer95 1 year ago The co-host is such a nice guy!!! Makes the podcast just perfect 4 Reply @ewastykowska3460 @ewastykowska3460 1 year ago As a person without any medical background I really wonder how to check my body response to the supplements recommended in this podcast🤷🏻‍♀️. I would like to know what blood parameters/blood tests I should check before taking the supplements and when to check out the results by retesting. My kind wish is to have the professor’s opinion whether the recommended supplements are safe for people with celiac disease? Could you also recommend supplements for people with serious problems with knees (deficiency of collagen and how to reverse that ?) Thank you for helping people understand what is going on with their own body❤️ 7 Reply @roberttorrie2651 @roberttorrie2651 5 months ago I HAVE BEEN ON NMN FOR 2. MONTHS AND HAVE NOTICED A DRAMATIC IMPROVEMENT IN MY ENERGY & A DECREASED NEED FOR SLEEP. THANKS FOR YOUR AMAZING CONTRIBUTION ❤❤❤❤❤❤❤❤❤❤ 18 Reply 8 replies @MsAdo1 @MsAdo1 1 month ago Maybe it is time for an update soon, regarding drugs and dosages? Would be very interested to know Dr Sinclairs view on liposomal delivery of MNM and resveratrol, for instance. Is a season two upcoming? Reply @therealtimray @therealtimray 1 year ago NR consistently raised my alt and ast liver enzymes during a year's worth of regular blood tests. NMN lowered my enzymes even lower than they were before taking NR in the first place. 9 Reply 2 replies @aaliyahlee1265 @aaliyahlee1265 1 year ago My life has changed after taking NMN supplement... I was very sickly and weak years ago, but when I learned about this product, it gave me hope to progress all the things I stopped doing before, like gardening.. I feel so alive and well with vitruvin NMN and trans-resveratrol.. 4 Reply 2 replies @t8qvnr @t8qvnr 1 year ago This is exceptionally interesting. I wonder if there are any studies addressing the additivity of the benefits of different supplements! If two different supplements increase the lifespan of mice by say 30% each, what is the combined effect of the two? 7 Reply @waldineytorres8578 @waldineytorres8578 1 year ago I'd love to know Dr. Sinclair's opinion on stereoisomers of resveratrol and pterostilbene, wheter it is just marketing or something else entirely. Fascinating conversation as always. 3 Reply @ericoshea9382 @ericoshea9382 1 year ago A potential topic for a future podcast could be fullerenes ( carbon 60). Just a thought. Great podcast—it is super informative! 1 Reply @LittleExplorer875 @LittleExplorer875 1 year ago What do you think about Berberine instead of metformin? I was reading is very effective as diabetes treatment and metabolism regulation. Do they work similarly or do they act on completely different metabolic pathways? Thank you, love the highly scientific quality of the podcast. 4 Reply 1 reply @havad3938 @havad3938 8 months ago Would love if you did a podcast on carbon 60, and then methylene blue, touted better than Retin-A for wrinkles. Thanks for all you do 1 Reply @brt042 @brt042 1 year ago Great list! Thanks. BUT I'm having difficulties tracking down supplements that are high quality (i.e. tested as labelled, safe and effective). How can I verify that a particular brand or supplement has been third-party tested? And how can I get a look at the third party lab report? Reply @MJFUYT @MJFUYT 1 year ago I discovered Dr. Sinclair from Dr. Andrew Huberman's youtube channel. This is amazing information from Dr. Sinclair. Thank you for sharing your knowledge! 4 Reply @benjamjo @benjamjo 1 year ago Love Your Work Professor. Thank you for all your hard work and willing to share your findings with us. I live in Sydney Australia. unfortunately, as you have mentioned many times none of these would matter unless we frequentley mesure and see how these molecules are effecting us. I am fining it deficullt to find clinics here in AU for instance to provide Biological age. Any chance you can provide some guidence on how we should go about it? 3 Reply 1 reply @kimboslice2821 @kimboslice2821 1 year ago Grateful for the information you guys are offering 🙏 3 Reply @mattboscan @mattboscan 1 year ago This video/podcast series is purely banging! Sadly I'm struggling to get my dad interested in it 😂. He moaned that it was boring and too detailed. Now I'm going to have to harvest the take aways and relay them to him. The things you do to keep you parents living longer ey?! Maybe I won't bother; I could do with an extra pad to chill out in... that was a joke by the way ; ) 3 Reply @FirstLast-lm8tf @FirstLast-lm8tf 1 year ago I think the risks of cancer are much greater with NMN and NR than people realize 3 Reply 1 reply @Alex24998r @Alex24998r 1 year ago Excellent questions- completely thorough and complete and intelligent and interesting- the questions that your colleague asked you, Dr. Sinclair. 2 Reply @woubshetwoldemariam9574 @woubshetwoldemariam9574 1 year ago (edited) I would really like to express my appreciation to z work u guys are doing. Keep up z good job! Bravo! 7 Reply @bombadeer8231 @bombadeer8231 1 month ago Thank you Dr Sinclair for nicotinamide riboside it has changed my life 🙏 Reply @prijha1 @prijha1 1 year ago Finally an interviewer that makes good use of time by letting Dave talk without interrupting and pushing off tangent. Thanks 1 Reply @JenP2776 @JenP2776 6 months ago I’d love to know your thoughts (or where I can find them if you’ve discussed this already) on curcumin and boswellia for use as anti-aging anti-inflammatories. Reply @christinagior42 @christinagior42 1 year ago I’m so grateful for having discovered you!! I hope to find the right manufacturers for these products.. 🙏🏼 1 Reply @Josh-ev6nb @Josh-ev6nb 1 year ago Can you elaborate more on metformin and berberine for (aging) athletes? What is happening with glucose? Is the total amount of glucose storage in the body reduced? Are we excreting it? Or do the molecules just help glucose more effectively get into tissue? So let's say I have a big ride the next day and I'm trying to tank up on carbohydrates. What's happening if I take one of these molecules with my high carb dinner? THANK YOU!!! LOVE YOUR WORK!!! 7 Reply @XinLi @XinLi 1 year ago What I've learned from your podcast so far is that right now is a great time to be a lab mouse. 4 Reply 1 reply @turnerrj4 @turnerrj4 1 year ago I know some doctors won't give out metformin unless needed. A good natural supplement as berberine does the same thing. It lowers my blood sugar and cholesterol naturally. I highly recommend it. 2 Reply 1 reply @rickemmet1104 @rickemmet1104 1 year ago Tweets, "David just tell us what to take." LOL! I've already implemented a bunch of lifestyle changes. These interventions will change medicine (which many will be unhappy with) but you all better change what you're eating and get to the gym too. Thanks David for the awesome podcast! 2 Reply @TheRitualistic @TheRitualistic 1 year ago Thank you for this podcast, very interesting! Sorry, but for non-scientists could you please explain whether taking NADH provides an NAD boost as well (the one I am referring to has Niacin NE (750mg) & NADH (6mg))? I read that NAD/NADH ratio is important and higher NADH would seem to speed up ageing... That doesn't mean that the NADH I am referring to (that is mainly Niacin NE) is not so good for ageing, does it? Sorry if this is a silly question! 4 Reply @luarfurness @luarfurness 11 months ago Dear Dr Sinclair, since following you for a few years, I've taken notes of all your recommendations in the above video. However, it's ever so confusing to understand which NMN, lipossomal, with phosphate, product I should purchase. I've been taking Liposomal NMN by Codeage, but where can I scientific, independent reviews regarding the so many products in the market? It's a labyrinth for us. I know you wish to abstain from any recommendations, but I'd be most grateful for some pointers. For example, if it's not liposomal and does not contain phosphate - no point? Also, if it's ND, NR, etc, forget it? This product is good as it also contains Resveratrol and Quercetin, but I see videos showing how so many dietary supplements contain nothing more than vegetables, and it's all about the marketing, and there's no supervision to check their adherence to the contents on their products. Some can even be detrimental to our health! Please guide us!!!! You can be the next Darwin! 1 Reply @vickydaisy1905 @vickydaisy1905 1 year ago Love all episodes of your podcast. 2 Reply @jawadkarim6615 @jawadkarim6615 1 year ago Biggest Salute to professor David Sinclair... 8 Reply @pietbiertappertje4529 @pietbiertappertje4529 1 year ago Great information and really well made podcast. I just wish these supplements (and combining it with bloodwork) weren't so expensive. My salary is not bad at all but not sufficient to pay for all this. 2 Reply 3 replies @tashmclaughlan133 @tashmclaughlan133 1 year ago Love your work Dr Sinclair ❤️ so interesting 👍 love to know a great brand of NMN to take? Any good suggestions would be much appreciated. 🙏 1 Reply @juliusctw @juliusctw 1 year ago When the study showed NR increased NAD, it was an increase in plasma NAD and not intracellular, right? For future episodes, can you talk a little bit about the difference between the two, and how each might be beneficial? 1 Reply @curioussameer @curioussameer 1 year ago (edited) Thanks so much!! Loving these podcasts. To add to the red wine conversation, one should reflect on the fact that Alcohol is considered group 1 carcinogen by American Cancer Society. The relative benefits of drinking red wine over 30 yrs would be vastly dwarfed by its dangers. I tried to copy past the website link but YouTube keeps deleting my comment. One can just google, list of carcinogens. 1 Reply @annedokubo2057 @annedokubo2057 1 year ago Thanks for a very informative and personally life changing information, @ David and Matthew. I’m based in the UK and wonder if there any information on companies like inside tracker. I’ve signed up to inside tracker but see they don’t currently deliver to UK. (Sad face) 2 Reply @cg4806 @cg4806 1 year ago NMN increased estrogen levels in a mouse model. An in vitro study that inhibited NAMPT resulted in increased p53 levels and acetylation, up-regulated BAX and p21 expression, and induced apoptosis in estrogen receptor positive breast tumors. Adding exogenous NAD+ removed these effects. In the absence of clinical trials, women with a history of estrogen positive breast cancer would be wise to avoid supplements that increase NAD+, until sufficient long human studies demonstrate their safety. 9 Reply 3 replies @explorersoftheworld1193 @explorersoftheworld1193 1 year ago thank you for very valuable and useful knowledge, I would be interested in the topic of fertility in women, how to care for it and whether it can be kept 2 Reply @shelthomas1075 @shelthomas1075 10 months ago Thank you for this information; Do you have an update to the studies referenced to be complete in 2022? Reply @HanaHana-sg2ng @HanaHana-sg2ng 1 year ago My friend has been taking NMN for 15 days she can not sleep since she started taking NMN. She said when she goes to bed at night she feels she drank 20 cups of coffee, she looks and feels very tired. She said she will keep taking it for a month and see what happens. I am health care worker so I work double shift back to back and I do not feel tired at all, before I started NMN I use to get extremely tired working double shift, now that I am taking NMN I could work double shift back to back and do not feel tired at all. No fogy brain any more. NMN is really working for me. WHy NMN did not work for my friend? 2 Reply @belindaluu1 @belindaluu1 1 year ago I love the pod cast and the supplement and practical tip recommends to stay forever young :) 1 Reply @aliciadidica2706 @aliciadidica2706 1 year ago How can I get blood tested with an " inside tracker " from Greece???? Thank you so much for your invaluable work and for giving us a chance to learn!!! 2 Reply @MickakaStiffler @MickakaStiffler 1 year ago Thanks for all the info! I would be very interested in the question from which age it makes sense to use things like NMN or NR. With it comes the question to determine the levels of NAD currently available in the body. Is there any quick and easy way to determine in order to avoid spending money on supplementing in case the levels are good? Or is there a general benefit for everyone to take it, like e.g. for vit D3 which is generally low in the population of countries that dont see too much sunlight? 20 Reply 3 replies @plamencho111 @plamencho111 1 year ago Thank you guys for that information. I was waiting for this podcast for a long time. Got NMN,Resveratrol, Apigenin, TMG,hylaronic acid 2 Reply 2 replies @joshannon6148 @joshannon6148 1 year ago I'll be 80 in a couple of months.I've been using NMN for almost a year. I'm pretty active. Walk on the average of 4 miles a day. I have an Oura ring which monitors my system. It rates me at optimal levels most of the time. My mother just turned 101. She's never been on NMN or anything like it. Just the average vitamins and exercise ( she was on three bowling teams most of her life and bowled up to the age of 96.). So, my point is, am I in this great healthy condition because of the exercise and supplements I take or is it genetics? 3 Reply 1 reply @lx556 @lx556 1 year ago This is pure gold, thank you so much! 1 Reply @milenavlaykova6026 @milenavlaykova6026 1 year ago Thank you for doing this videos Dr. Sinclair and sharing your information with the world! I wonder if there si anybody who could advice on which companies are reliabale to buy NMN from In Europe? Reply @dawnsutherland4834 @dawnsutherland4834 1 year ago Hi Dr. Sinclair, what is your opinion on the reported adverse effects of NR/NMN on protein synthesis and hypertrophy? 6 Reply @jeffmiddlebrook5251 @jeffmiddlebrook5251 1 year ago I knew this podcast would change everything...I would need to know about my lifespan. 4 Reply @RiaanEloff @RiaanEloff 4 months ago Am I being silly, or is this a valid question: should one consider taking NMN, Reservatrol and Metformin simultaneously, or will they work against each other? Reply @lakshmiprakash4068 @lakshmiprakash4068 1 year ago Great to know all of these molecules. Thanks for the information 2 Reply @newpersonal3762 @newpersonal3762 1 year ago (edited) I'm looking forward to listening to this. I hope you talk about olive oil and avocado oil. Many health benefits. 5 Reply @ginacardarella @ginacardarella 5 months ago Thank you thank you for this podcast and especially the show notes Reply @nicolettetomblyn994 @nicolettetomblyn994 1 year ago I was put on high doses of metformin for fertility it worked very well for me (mom of 4) 9 Reply 2 replies @delaneyondreams @delaneyondreams 1 year ago (edited) If you could comment, when relevant, if 70+ year olds ( 60 inner age) need to follow different guidelines, or if we have not been studied, or if results or effectiveness for us would likely be different, I am sure we would all appreciate the information. Cheers and thanks to you and Matthew. 3 Reply 1 reply @pqncrypto4421 @pqncrypto4421 1 year ago I usually never wait for podcasts releases…. But this one is much different! 3 Reply @ranamukherji2395 @ranamukherji2395 1 year ago These episodes are quite helpful and appreciated. (And yes, "sedentariness" at 5:15 is a word, sadly.) Reply @Articulate99 @Articulate99 1 year ago Always informative, thank you. Reply @deepdusto @deepdusto 1 year ago wow, I cried when I watched this, it answered few of my burning questions that no one else could address. Great channel. Reply 4 replies @nursechase1 @nursechase1 7 months ago (edited) I would like to see a larger study showing whether or not NMN affects testosterone levels in human males. Included measurements of LH, FSH, Prolactin and estrogen levels would be helpful. I am interested but until I have more information hesitant to start supplementation. Reply @felixr.6438 @felixr.6438 1 year ago Thank you for another very informative episode! I have a question though. At what age do all those measures even start to pay off? I'm 26 years old and I live healthy. Everytime you mention a supplement I ask myself things like "Do I even have senescent cells, that I need to kill? At what point in the future should I start taking quercetin/NMN etc. ?" 5 Reply 2 replies @nazfathi @nazfathi 1 year ago Thank you for this podcast! You were taking baby aspirin at one point to prevent bowel cancer, have you removed that from your protocol? I was diagnosed and cured of bowel cancer but I am not sure if I should start taking aspirin daily for prevention 4 Reply 2 replies @uberandreman @uberandreman 1 year ago I love this podcast, and the format. However, I was wondering if there is room for special episodes where you have another researcher alongside you that might be able to add some criticism or another perspective to the research. I came across Dr Rhonda Patrick's video on Metformin for healthy people who exercise, and she seems less enthusiastic about the research. I finally found a review of the literature from last year that gave me a better understanding, but I was wondering if you could make this more efficient. My thought is, maybe you can have someone like Dr Rhonda Patrick on, and discuss a set topic that neither of you too fully agree on, like Metformin. Not to debate necessarily, but to get a more complete view and really flesh out the current state of the research from multiple angles. Matt can still be the moderator, he's great! 14 Reply 3 replies @Paulsapartment @Paulsapartment 1 year ago (edited) Thanks!! But I wish you had mentioned something about Metformin and PCOS. I am 62 now and people often are shocked when I tell them that’s my age but I’ve been taking metaformin for PCOS since I was 25. I’ve now gone through menopause and my doctor said sure keep taking your thousand milligrams a day it won’t hurt yet so I am 3 Reply 1 reply @roverdover4449 @roverdover4449 1 year ago I'm really happy he talked about diet and exercise first, before supplements. That gives serious cred. Still, of course, I want to know about the pills. Reply @benjaminsommer687 @benjaminsommer687 1 year ago Question: adjusting for for allometric scaling I should be taking about 2g of NMN a day (based on 400mg/kg for your mice). You and I appear to be about the same weight, Dr Sinclair. Is there a reasoning for you only taking 1g? 2 Reply @lelle9901 @lelle9901 1 year ago He mentioned the liver being sensitive to some of these supplements. I took resveratrol and NMN for 6 months until I've got tingling in my hands and a rash on my face and neck/chest. My bloodwork showed that my liver was not happy at all, even though I was perfectly healthy before (very active on a good diet, mild diabetes 2 controlled with diet and exercise. My A1c level is 4.8). I will never know for sure whether the issue was caused by resveratrol or the NMN, or that maybe I used a formula that wasn't pure enough (although my NMN powder cost 500 dollars). Now, I'm scared to try either because it took me several months to get rid of that rash and see better lab work results. However, this was two years ago and neither the rash nor the tingling has returned, and my liver markers look fine, so there is no doubt that I took something at the time that my liver didn't like, and the only supplements I took back then were resveratrol and NMN. 9 Reply 3 replies @moneytalkswithchu @moneytalkswithchu 1 year ago I don't know comic books enough, but seems like Dr. David Sinclair could very well be the start of a comic superhero scientist story that discovers a superpower in a lab by an accident. Reply 1 reply @ableinternational3611 @ableinternational3611 1 year ago Thanks for this great podcast. What are some reliable brands that we can buy these supplements mentioned? 2 Reply @johnkelley1426 @johnkelley1426 1 year ago Doc, loved the book, interviews, podcast, especially the hard science. Thank you. Consider consulting your daughter, sons, wife, and Matt - to occasionally crack a small, tiny smile of confidence. Not a Howdy Dowdy maniacal grin; rather small smiles of confidence that you're on the right track. Following that dim light of scientific evidence and understanding while realizing its setbacks and pitfalls. Thanks. 2 Reply @mbbrooks123 @mbbrooks123 5 days ago I had heard of NMN on another podcast about a year ago. I then dud a little research and started taking NMN. I found out it that it has changed my life for the better. My anxiety had pretty much gone away. My energy is by far more focused, and for the most part, I feel great. I have other heath issues that dragged me down prio to NMN. I've tried many supplements and haven't had any luck, but NMN is doing wonders for me. I have bought a year supply since places have quit selling the product. Reply @ferpena1978 @ferpena1978 1 year ago It would be nice if you guys could elaborate a bit more on the pancreatic cancer mice since it's a bit worrying with so much evidence showing that NMN does not increase and even slows down some types of cancers. 3 Reply @marcocoltelli5975 @marcocoltelli5975 1 year ago I am marco from Italy, I have already read your book and I have found it fantastic! Naturally all your suggestion are focused on US market, I hope one day you'll have also some suggestion about italian or european provider for blood rest, dna test etc. Supplement are quite easy to find though. 7 Reply 3 replies @rawrnr1 @rawrnr1 11 months ago So confused with NMN - so many brands!! Can you recommend any? ALSO I appreciate the science around the vegan diet! I've been vegan 24 years! Reply @rustymcrae7739 @rustymcrae7739 8 months ago I'm really trying to find a way to get metformin in the UK. I'm not diabetic but after hearing Sinclair talk on both Huberman and Rogan I want to start taking it! Any tips on how to either game the system or the best country to ship it in from? Reply @simonebrighina8262 @simonebrighina8262 6 months ago (edited) HI, I have a question for @DavidSinclairPodcast Do you advise to integrate with NM or NMN? Is there any study that can support the difference of absorption between NM and NMN? I read that NM and NMN need to be stored in a cold environment to avoid degradation, it implies that 99% of the supplement that are sold will reach the customers without any active principle, so they are useless ( I saw some tests done), is this right? What supplement is the righ one and where we can buy it in Europe (I am Italy based)? Thank you Reply @kristiang6160 @kristiang6160 1 year ago Hi David. :) thank you for this Podcast. To the relevant doctor or the right person who can answer. Or Dr. Sinclair. Sorry for my lack of knowledge. I do not have an education in health. I am just curious about this and want to be sure. By supplementing 500 mg NMN, will pro-oxidant or reactive oxygen species (ROS) could occur. I do not know the process of this. I want to make sure this can not happen. Sorry for my unawareness. I really appreciate any help you can provide. Reply @loudboomboom @loudboomboom 1 year ago I’m curious how age factors in to some of these supplements. Like does the resveritrol, NMN, etc. routine make sense for someone young and healthy? When should one start? Reply @susanwoodward7485 @susanwoodward7485 1 year ago (edited) Any information on pros/cons of NAD+ boosters or infusions in non-diabetic ckd? Superb series Thank you. 4 Reply 1 reply @dominiquejasperson900 @dominiquejasperson900 4 months ago Dr Sinclair, I stopped taking Resveratrol because of the criticism out there. But when I stopped, I felt pain in my knees, which have stage 4 osteo arthritis. When I went back on Resveratrol, the pain went away. At least in my case, Resveratrol helps inflammation. There appears to be more to it than whether or not it activates SIRT1. Reply @lucabrazi36 @lucabrazi36 1 year ago Great info!! Looking forward to more videos!! 1 Reply @espinozafn @espinozafn 1 year ago God Bless Joe Rogan for getting this guy's name out there. This is powerful information. 2 Reply @s3731711 @s3731711 1 year ago Can you make a podcast about "superfoods" or just foods we should be getting more of in our diets? I take supplements but I really like the idea of getting or at least trying to get more of my good compounds from food and behavioral change. 1 Reply @miked319 @miked319 11 months ago (edited) David, is the injectable or IV form of NAD+ better than the NMN powder? And what about the nasal sprays and patches? I know they are more costly but are they more effective? Thanks 1 Reply @radubetea5724 @radubetea5724 1 year ago Am inceput postul intermitent in ultimele zile ale anului trecut.După trei saptamani am facut o verificare si vârsta metabolica a scăzut cu 4 ani.fata de cat era anterior...inca mai am de recuperat,dar imi place foarte mult noul stil de viata. 10 Reply @guuseh2918 @guuseh2918 1 year ago For the first time, I am able to hear comprehensive analysis of what substance does what. Bravo! Thanks to you and your team David. My previous understanding is that senolytics (Quercetin, Fisetin e.t.c.) should be adopted in a 'hit-and-run' approach i.e. they should be cycled as you don't want them hanging in the bloodstream for too long, what is your take on this? And do you take 1 g of wheat germ extract, or 1 g of spermidine? I was thinking I g of spermidine is a lot? Thanks for your work. 7 Reply 3 replies @christinem367 @christinem367 11 months ago I would like to read more on the difference between liposomal supplements and "regular" ones. It's difficult to understand the grams ratio. The lipo supplements claim to be better absorbed and seems to provide much less grams than the recommended amount in those videos, no matter what the content (resveratrol, NMN, etc). Anyone has more info on this? Reply @frankerororo @frankerororo 1 year ago Can you recommend where we can get nmn, quercetin, fisetin and spermadin? Appreciate your help to make the advice actionable Reply @dominiquezivkovich-brady @dominiquezivkovich-brady 1 year ago Love it team. Well done. Thanks. 1 Reply @vincentv5000 @vincentv5000 1 year ago Thank you for the information.. just joined the levels membership.. inam diabetes. But my doctor refused to prescribe CGM for me for two years ..I need this machine for supervising my intermittent diet . Finally got it .. 1 Reply @02ity @02ity 1 year ago (edited) Clarification: I am excited about your work. I am hungry to consume it all (pun). Just want to make sure everyone is on board with your findings and the results can not be corrupted. 5 Reply 2 replies @franciscachesca @franciscachesca 9 months ago Great interview, very helpfull. Thank you so much. Reply @lorrainebauer1336 @lorrainebauer1336 1 year ago David, can you comment on the effect of Metformin for aging on the gut microbiome? There is so much being said about a healthy gut microbiome, does Metformin contribute to or detract from a healthy gut microbiome and how? Reply @serge_stauffer @serge_stauffer 1 year ago Thank you for this very informative podcast. Grapeseed-Extract seems to contain another promising senolytic (PCC1). I also like it, because it is nothing highly processed. On the other hand I am not sure, if there are negative interactions with NMN and Resveratrol, which I already take. Should I cycle Grapeseed-Extract with for example NMN or can I just take everything at the same time? Reply 1 reply @MrsMarie-kh7fe @MrsMarie-kh7fe 1 year ago How much berberine should you take to equal Metformin? I would like to take NMN but am now worried about it causing cancer growth. Great podcast! I am glad I found it! 13 Reply @faridjasemi3326 @faridjasemi3326 1 year ago Thank you Dr. Sinclair and Mr. LaPlante for the podcast. I have been fasting since I saw your interview at Joe Rogans and like to try some of the supplements you are taking. I understand you do not recommend taking any of these but do you have any trusted source where we can purchase these? Your good friend (and podcast twin) Dr. Huberman recommends Thorne which does not have what you were speaking of in this episode. Thanks again for your work 4 Reply @bernhardbrix969 @bernhardbrix969 1 year ago Dear Dr. Sinclair. I suppose you test for NAD to check the effects of resveratrol, NMN and Spermidine. What are the marker to look for regarding the supplements that aim at mTOR reduction (Fisetin, Quercetin) and AMPK aktivation (Metformin)? 3 Reply @ivojankov7811 @ivojankov7811 1 year ago Dr. Sinclair I have a question regatrding the NMN, does the phosphate molecule alows it to enter the cell or does the NMN need to convert again to riboside in order to be able to be absorbed? Thank you in advance. 2 Reply @9xqspx6 @9xqspx6 1 year ago What I didn't completely understand regarding Fisetin: first dr. Sinclair said (46:46) "We still have to wait to see if it's really truly safe." But then at the end he said, he takes 500 mg of it daily. I'm considering taking it for lowering serum uric acid levels and am now confused it's safe or not. Otherwise great and much appreciated information, thank you! Reply @bapcorp8303 @bapcorp8303 1 year ago (edited) Metformin is a very effective drug, it does have a long list of strong side effects.. eg- reduced testosterone, hair loss for example, it's worth taking the time to consider if the side effects are worth it. 2 Reply 1 reply @remymay3632 @remymay3632 1 year ago I seem to recall on the Huberman podcast that daily Resveratrol in one mice study didn't actually extend their lifespan, even though they were healthier, whereas intermittent days did have the life extending effect. Some more information about this would be very much appreciated. I'm taking everything every other day now, or a third day, until I hear more.. 1 Reply 1 reply @NHAMONT @NHAMONT 1 year ago thanks for sharing your knowledge with us please talk about autoimmune diseases Reply @13Nicozurdo @13Nicozurdo 1 year ago Hi David and Matthew! I have a question, does berberine have the same effects as metformin regarding training? I do train 5 days a week, and I'm not sure If 2 days a week of taking it will have a "decent" impact on my health. Thank you!! 4 Reply 1 reply @kenhansen2832 @kenhansen2832 1 year ago Hi David ☺️ I have read your book and are using the same supplements as you do at page 304. Did you stop using some of your supplements compared to now? Reply @sandrajensen3023 @sandrajensen3023 11 months ago I am almost 49 and have been taking NMN, TMG and Resveratrol for about 2 months when I suddenly developed terrible RLS that caused me to barely sleep all week. I added b vitamins with very little help. I plan on stopping my supplements to see if this improves. I have never had this before and am wondering if anyone else has had this happen and is there anything I can do to stop it?? 1 Reply 1 reply @hollystarseed4917 @hollystarseed4917 1 year ago Thanks so much David for your wisdom! Does anyone have the referral code for Levels? I didn't catch what we need to enter once we follow David's link Reply @adamloepker8057 @adamloepker8057 8 months ago (edited) The 20 seconds of trolling starting at 38:07 is my favorite by far... this series is great! Reply @angev60 @angev60 1 year ago Final!! Waited forever for this episode! All episodes are very interesting. Just got the book!!!!!! Reply @iancullen861 @iancullen861 1 year ago I took Resveratrol 200mg daily for aprox 5 years and during that period I found i had an erratic heart beat that doctors said was there for the rest of my life believing it was something else, however after stop taking Resveratrol it stopped and my energy level went back up (i felt), nt knowing it was the Reveratrol causing it I went back on it and bang that confirmed it, so I would strongly suggest Human studdies. 5 Reply 3 replies @Eva-jc8sx @Eva-jc8sx 1 year ago (edited) Many thanks Doctor Sinclair!!!! If you ever need volunteers in Mexico for your research, I am more than happy to participate 🤗. I just got my NMN pills!!!!!! So 1G a day, with resveratrol along with some olive oil... and how long should I wait to eat breakfast or lunch? .. Reply @rosatranslations @rosatranslations 1 year ago I’m prediabetic, I could not believe it because I’m always training for marathons, Ironmans, rowing, and paddleboarding. I don’t eat sugar. I normally do 15 hours of intermittent fasting 5 times a week, but no more than 15 hours because I train a lot. Since I’m using a CGM, I learned that my blood sugar rises first thing in the morning. I also learned that is normal for some people, so I quit having breakfast before my training of one to two hours. Lately, I have been training on an empty stomach and still, my blood sugar rises from 95 to 180, I only drink water during that time. Any suggestion to be able to control it? Maybe this could be a topic for a future episode? 🙏 Reply 2 replies @Jamie.Richards @Jamie.Richards 1 year ago (edited) I started supplementing trans-resveritrol late December, 500mg per day on week days. I took a blood test early Feb and the results show my SHBG are up 30% to 73 nmol/L. This has reduced my free testosterone levels. I've just read some studies linking resveritrol to increased SHBG levels. Is this typical? Is there a way to control increased SHBG from resveritrol? And is higher SHBG an issue, other than lower free test levels? I'm not sure how to weigh up a short term drop in free test vs a long term gain in longevity. Would greatly appreciate the science behind this. Edit: I also went vegan for veganuary and started taking ashwaghanda, so my total test was up, and I've read vegans have higher SHBG levels than vegetarians. 1 Reply 1 reply @jet30d @jet30d 1 year ago I’m in Australia and have discussed taking NMN and Resveratrol with my GP. He has no idea what I’m talking about😁. I’m on an immune suppressant for Crohn’s disease and wondering if taking these supplements would affect the efficacy of the suppressant. I have searched everywhere online and there is data on it. Hoping someone has an answer or is taking NMN who has Crohns. Ta!! 2 Reply 1 reply @virgillumia9031 @virgillumia9031 1 year ago Maybe the one with the phosphate works better because that phosphate part acts as a binding point to the transporting proteins involved in the further transformation of the molecule Reply @LianaBuzea @LianaBuzea 1 year ago I can't wait for the episode on hair regrowth / regeneration. I know it was a topic announced for future episodes. 🙏 32 Reply 7 replies @CavaloTM @CavaloTM 1 year ago Great podcast and a lot to learn. I live in europe and looked up what your whole supplemention would cost. For this I have exchanged metformin with berberine because you cant buy it. And im not sure if every supplier is 100% thrustworthy. That would be the equivalent of 250 dollars per person per month. Without Inside Tracker / Levels or vitamin supplement. Is this really affordable for the everyday person in the US? 5 Reply 1 reply @MsAdo1 @MsAdo1 1 month ago Maybe it is time for an update soon, regarding drugs and dosages? Would be very interested to know Mr Sinclairs view on liposomal delivery of MNM and resveratrol, for instance. Is a season two upcoming? Reply @ninaninabonita @ninaninabonita 1 year ago David, have you heard of Dr. Shiva? Hes an MIT PHD in computational systems biology and has invented an amazing software program called Cytosolve that can show what molecules and their combinations with one another do to our biological system as a whole. It would be very beneficial to see you collaborate! 3 Reply 2 replies @sumitagg1 @sumitagg1 1 year ago David - please comment on Peter millers study that showed no benefit of resveratrol even at high doses. In The NMN paper you referenced, the majority of the benefit was driven by 2 patients. Most patients had a minimum benefit 1 Reply @ronjean6034 @ronjean6034 1 year ago Excellent. Just to have this support information is comforting ( i do follow this advice? maybe not to the dosage amount because of costs) but apart from Metformin, I have most others covered. Time will tell - maybe I see you in 100 yrs? Reply @katherinediane4673 @katherinediane4673 9 months ago (edited) Can you please address the minority of people who feel absolutely exhausted taking NMN? I take TMG one to one with it. I also take Resveratrol and Quercetin. I’m a 59 year old healthy female taking no prescriptions. Thank you! Reply @tobiasgerke9942 @tobiasgerke9942 1 year ago Thanks David. Great podcast. Could you comment on the study that "Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults" from 2014 that found no possitive impact in humans (in JAMA Internal Medicine (2014; doi: 10.1001/jamainternmed.2014.1582) 13 Reply 3 replies @lyndan438 @lyndan438 1 year ago My biggest takeaway: the conversation about mice being predisposed to cancer (certain type(?)) and NMN stimulating cancer growth (as in the 2019 study that was discussed). It feels as though that wasn't given enough emphasis, should I be cancelling my order for NMN? 12 Reply 2 replies @sheldonsmith4089 @sheldonsmith4089 1 year ago Great content! David, I am type 2 diabetic .What supplements(how much) would you prescribe if you were Type 2. Thanks 1 Reply 1 reply @DUDIDUAN @DUDIDUAN 1 year ago NMN does not work for my family at all. NR works really well. You can feel improving sleep quality immediately. 2 Reply @sab1024 @sab1024 1 year ago Curious about TMG. I am taking it. Seems to be well tested. Reply @oldskooldriver9379 @oldskooldriver9379 1 year ago (edited) Has anyone studied increase bioavailability of the NAD boosters if taken orally prior to intense exercise (while fasted or not fasted)? I take 1000 mg of NMN prior to an intense workout (HR > 90% for 30+ minutes). I notice that my endurance seems improved on the days I take NMN before my workout, and my pool swim times support a modest increase in speed for the longer swims (> 100 yds). I especially feel more elastic lung function after intense workouts with NMN compare to without NMN. Blood flow in muscles can be 20x greater during exercise compared to rest. 1 Reply @hightierplayers2454 @hightierplayers2454 1 year ago Someday I will be younger than when I heard this episode for the first time with the information being shared. 10 Reply 1 reply @ivetteanziani4083 @ivetteanziani4083 1 year ago Good to hear, I been taking resveratrol in powered form and mixing it with water🥺 Reply 1 reply @jonbaldridge2621 @jonbaldridge2621 1 year ago Can MNM cause a disruption in sleep cycles, or could poor sleep be the result of the powder degrading into nicotinamide? Even a dosage as small as 10 mg diminishes my sleep quality. Incredible cogntive and physical booster. Reply @tpfth1986 @tpfth1986 1 year ago Thank you both of you for really educational podcast..I am really a poor man with too many health problems,I like to try using Resveretol Please please please can you just write what make you use so I don’t spend my money on wrong product and get worse than what I am now healthwise??If you don’t write you are giving opportunist people to make money on bad products.🙏 Reply @breathewithchrissyd @breathewithchrissyd 1 year ago How does Pterostilbene compare to Resveratrol? I’ve read that Pterostilbene stays in the body longer and that it is better absorbed into the body. Thoughts on this? Reply @bonniedavis9076 @bonniedavis9076 7 months ago I have covid I'm 64. within 2 weeks I could feel it in my lungs. I took nac because I had it. I started reading about it. Along with my NIR panel which I used 10 mins on front & back. The pain & breathlessness have left. I'm taking 2400 of nac for next 3 days Reply @aussiecfo @aussiecfo 1 year ago Great work, great information. 4 Reply @dailybibleverses4903 @dailybibleverses4903 1 year ago There’s another side effect of metformin, it causes skin problems to some people. I developed a skin rash (an inflammation) that persists even today that I have stopped taking it. It’s slowly going away. 1 Reply 1 reply @hollyhawks8899 @hollyhawks8899 1 year ago (edited) Great info! thanks i have been taking resveratrol ... I now know the dosage was far too low! i wish i could find a doctor who will prescribe metformin, since i'm healthy weight and no diabetes she will not even consider the prescription even after a lot of begging...Rock on! 1 Reply @deni7457 @deni7457 1 year ago Everyone share David Sinclair’s channel with everyone!! More subscribers = more content= more healthy and young people. 1 Reply @delishme2 @delishme2 1 year ago (edited) Just to digress a little.... Anyone having C Vaccine or boosters should consider senolytics. Studies are finding there is a two week period post jab where senescence increases. It may be a good time to clean up some of the cellular junk. Anecdotally, I did it both pre and post and had almost no symptoms, which for someone with several comorbidities was a relief. Quercitin is also an ionifor, so great to have on hand with zinc in case you become positive. 😊✌️🇭🇲 Reply @warner476 @warner476 1 year ago Thinking about the use of antibiotics on the environment (found in water and fish), I'm wondering about the environmental impact if millions of Americans take Metformin or other drugs you talked about. What is the post-body composition? Reply @bobgilmour3172 @bobgilmour3172 1 year ago Late last year Dr. Brad Stanfield did at least a couple of podcasts debunking your work on Resveratrol, which seemed to me to dredge up Big Pharma’s earlier hit job on your work. Would much appreciate your analysis of this latest attack. 4 Reply 3 replies @tradet8767 @tradet8767 1 year ago (edited) Hi, What happens if you take NAD for a period of time and then discontinue the regime? Are there any drawbacks if you stop? Reply @marlenem4385 @marlenem4385 1 year ago Can the anti-aging medications/supplementation strategies serve as a proxy to help correct menopause hormonal loss in a way like HRT does? In other words in the absence of HRT, can these improve or affect hormone balance. Any insights? Thank you 🙏 3 Reply @newpersonal3762 @newpersonal3762 1 year ago The french paradox should be thought of with consideration to all the olive oil and you've acknowledged it's much more potent than resveratrol. It's better to contribute it to that than to something you said a person can't drink enough of to get the benefit. 2 Reply 1 reply @ottot3221 @ottot3221 1 year ago (edited) I remember in the first episode we where promised information about brands of these additives that are safe to use. Is that still coming? 9 Reply 1 reply @bernda.neubauer137 @bernda.neubauer137 1 year ago Sorry David and Matthew, 1 gramm of Spermidine? This is really a lot, isnt it? Most supplements come at 1 mg per pill, or am I mistaken? Great channel by the way. Cant wait for your new book! 4 Reply @markc8046 @markc8046 10 months ago If anyone reading these comments is looking for resveratrol they should try vinia because it's the only one that uses piecied resveratrol which is 20x more absorbed than trans resveratrol (which is what all other resveratrol supplements are using) Reply @sirwalksoftly @sirwalksoftly 1 year ago 1:05:00 I'm curious to know if taking NMN every OTHER day would also be effective at raising NAD levels over that 10-day span that Dr. Sinclair mentions. It would be great to somehow get this answered by you gentlemen! 1 Reply 2 replies @leighgronet4306 @leighgronet4306 1 year ago Is there any studies on how Metforman affects the liver over time? It is a drug after all and the liver/body generally doesn't like those. Been on the NMN a few weeks 3X/week, Alive by Science sublingual 2 pumps. Been getting on and off pain in the left big toe. Is this a typical side effect that will eventually go away? Reply @winsomeam4168 @winsomeam4168 1 year ago I mentioned taking resveratrol and NMM to my rheumatologist and he said he’s never heard of it, don’t know what I’m talking about. I’m in my 70s, been diagnosed with systemic lupus and had early stage lung cancer a few years ago. Which article should I use to refer him to this subject? BTW am a great fan of yours Doc ! Reply @dropclutch1 @dropclutch1 1 year ago Thank you Dr. Sinclair! Be well! Reply @marinafoglietti9351 @marinafoglietti9351 1 year ago (edited) Thank you Dr. Sinclair, for all these interesting informations. I'm taking 0,250 mg a day of resveratrolo in the morning from this week, with yogurt and a little bit of olive oil; I have ordered NMN for next week. In the meantwhile I am so excited❤❤ 6 Reply 3 replies @hangglidinglife @hangglidinglife 1 year ago Very well done Sir! I am looking for the best resource to purchase NMN and Resveratrol. thank you so much! Dang, you look like you are in your 20's. 1 Reply @traceyfrazer2073 @traceyfrazer2073 11 months ago What brand of NMN do you recommend? And do you recommend the sublingual route for taking it orally? And is liposomal versions the best way to take the supplement? Reply @frenchmontana423 @frenchmontana423 1 year ago hey you guys spoke about the cosmetic aspects of this all. is that episode out yet? thanks 3 Reply @robinaakrammalik220 @robinaakrammalik220 9 months ago Dear David. I'm 65years young, residing in uk. I had been watching your progress since more than 10 years. I have started taking NMN fast desolve dietary supplement GMP, FDA registered, I'm taking 8 tablets a day 4+4 empty stomach, after noon and evening. Since 22nd October 2022. And feel good. I further need your suggestions regarding my intake and if some other tablets you recommend, so that I buy that next month. Looking Thankx a lot. Stay blessed 🌷 Reply @Alex-dd3oy @Alex-dd3oy 6 months ago Interesting how you never mention where people can buy these supplements. Most supplement companies sell cheap placeboes for large margins. They're protected by the FDA disclaimers. A discussion on how to find reliable vendors should have been the first topic covered in this episode Reply @freedomwarrior5241 @freedomwarrior5241 1 year ago (edited) Loving your series, thanks so much! Is there anywhere I can ask you a question? If not will try here. If I drink "bulletproof" coffee (MCT OIL & BUTTER in my coffee can I still have that in the am and not eat until lunch and eventually dinner is that still effective per your timed eating? P.S. Limited is not available for my area, Arizona. Very disappointed! 5 Reply 4 replies @andrealeith2251 @andrealeith2251 1 year ago Hi David . Your podcast could be a life saver for many . My question to you is . My GP has put me on Ozempic . I don’t have diabetes . It is for impaired mobility and weight gain due to injury . Is their a similarity in efficacy between Ozempic and Metformin ? Does Ozempic biochemistry help with longevity ? 1 Reply 2 replies @khaledzurikat7190 @khaledzurikat7190 10 months ago This is problematic: we cannot do this on our own because we will not know what we’re doing. and our doctors will probably not entertain this and we don’t have access to constant biomaterial monitoring. But it worries me if some folks just go and blindly do the same thing as Dr Sinclair who is clearly experimenting on his own body Reply @TheTenThousandThings @TheTenThousandThings 1 year ago I have a question about contraindications between Resveratrol or NAD boosters and Mucuna Pruriens. I read on an ayurveda website that mucuna shouldn't be taken in combination with anti-diabetic drugs. Given that res and NMN etc are being lumped together with metformin in this podcast I wonder if there's any possible negative effects by combining the two. I sometimes take mucuna in the mornings with my other supplements but sometimes not because the nausea is pretty bad. 1 Reply 1 reply @44_max3 @44_max3 1 year ago You mentioned quercetin and fisetin as a maintenance dose. Does that mean that you ran the high 2 gram dose of each once a week in the past, for several months, following the mayo clinic study, to kind of "clear out" or "blast out" senescent cells, then afterwards switched to the 500mg maintenance dose? Reply @JohnDeanMusic @JohnDeanMusic 1 year ago You guys are changing my life. 1 Reply @halnineooo136 @halnineooo136 1 year ago Any Q&A session some day on your channel? Thank you for the invaluable information. 12 Reply @jainubeezy1 @jainubeezy1 1 year ago What dosage of NMN and Resveratrol does the doctor recommend? Reply @bill9989 @bill9989 1 year ago I've been taking metformin for 6 months. I recently bought a red light/Near Infrared light. As I understand this video, metformin reduces mitochondrial energy whereas the red/NIR light increases mitochondrial energy. Is there a conflict with using both, e.g. daily metformin and every other day light therapy? 3 Reply 1 reply @1stbassnyc @1stbassnyc 1 year ago if i had to choose between NMN or TA65, (both by revgenics) which is best to help combat the negative physical effects of aging? btw, I'm super fit 50 yo male Reply @anitarane5066 @anitarane5066 1 year ago You too are a great team. Fantastic podcast. Just curious David the bracelet in yr wrist for longevity😁 Reply @shazk21 @shazk21 1 year ago (edited) As someone studied in molecular biology and crystalline catalytic the molecular engineering behind this kind of technology is what interests me unfortunately the the majority of the cutting edge is sealed and open discussion difficult Reply @sunshinecitypersonaltraini7228 @sunshinecitypersonaltraini7228 1 year ago Great episode, thank you! 4 Reply @cynthiabaumhauer8403 @cynthiabaumhauer8403 1 year ago I don't have a script for Metformin but am taking Berberine. Is it as effective as Metformin or should I get Metrormin? 3 Reply @lisataylor7516 @lisataylor7516 1 year ago I love Your podcasts! Reply @MegaMendeleev @MegaMendeleev 1 year ago Hello and thank you for all the information. I have actually ordered nmn and as I wait for the delivery am wondering do one have to take TMG also as it is suggested that taking nmn deplete methyl pool in the body. 3 Reply @alicemaarouf3911 @alicemaarouf3911 1 year ago How long do you think it will be before all of this is combined into 1 longevity pill ? Reply @1Bridem @1Bridem 1 year ago We are not Drs but David is way above a standard medical Dr.,lol 5 Reply @peterjensen9671 @peterjensen9671 1 year ago I take my resveratrol suspended in a spoon full of olive oil every morning. The oil is Italien virgin olive oil that I get from a friend of a friend who has a small olive plantation. Super quality. 3 Reply 2 replies @devtestdevtest9014 @devtestdevtest9014 1 year ago Tnx for brilliant podcast ❤️ Reply @theleechqueen @theleechqueen 1 year ago (edited) David. What do you think of the claim that someone's ability to touch their toes or lift themselves up from the floor without using their hands could serve as predictor for longevity? Does that have any merit? Reply @therealtimray @therealtimray 1 year ago Plenty of studies show that past a certain threshold of resveratrol consumption, starts to have negative results. 100-200mg is the sweet spot from what I've seen Reply @balancedbodyjk @balancedbodyjk 1 year ago (edited) Good video! I have question. I have been following your routine taking 1g of NMN, resveratrol, and 500mg TMG for a few days. I take it in the morning. But it makes me sleepy so tired all day. Is that normal? Will it go away? Thanks! Reply @lukejagodzinski @lukejagodzinski 1 year ago Maybe, you should consider creating short clips out of those podcasts to bring more people to podcast? Most people don't have time to watch 1 hour long podcast to check if it's good or not. I think most people that watch your podcasts are already familiar with what you do and how good they are. But we should spread the world so more people are aware what you can do today to prolong your life. Keep doing the great work! Reply @goldgold4943 @goldgold4943 1 year ago Sinclar, the god of anti aging 6 Reply @KrazyDiamondBar @KrazyDiamondBar 1 year ago Had to wait until the end but finally got some questions answered. I did have another about refrigeration of one or all of these. On Rogan you mentioned Resveratrol needed to be delivered and stored refrigerated, plus there are so many snake oil salesmen out to make a buck, can you include quality manufacturers and refrigeration concerns in the description? I took Resveratrol and it didn't sit well with me and then I remembered you saying it could have a level of toxicity and decomposition if not refrigerated (the supplement form). Much thanks. 🙏 Reply @tadmarshall2739 @tadmarshall2739 1 year ago If you do a sequel on anti-aging supplements, perhaps you can talk about alpha ketoglutarate. Reply @orionbaden-powell1496 @orionbaden-powell1496 1 year ago cant wait to hear about testosterone, and also how the above supplement impact people with adhd? Reply @szman167 @szman167 11 months ago You should look into Luteolin, when taking with Quercetin it gives me brain activity, I remember my dreams every day now, so I know its reversing aging. 1 Reply @arcadiapeek6856 @arcadiapeek6856 1 year ago Prof. Sinclair, I have a question regarding the bioavailability and solubility of resveratrol. Let's say I dissolve it in olive oil and take a shot of this solution in the morning. This is my question: Once this solution gets to my stomach (which is not full of olive oil), wouldn't the resveratrol simply crash out? Pharmacokinetics mediated by a carefully designed capsule whose purpose is to release a drug in a certain environment is a bit different than throwing resveratrol into an olive oil solution -- right? Note: Thank you for sharing the literature and tools one can use to live a healthier life; it has already positively impacted my life and I expect that it will continue to do so for the foreseeable future. 1 Reply 2 replies @izimmt @izimmt 1 year ago (edited) I can tell from my experience, when taking NMN , my wounds close quickly(a week), and without any scar tissue. (a white line on the skin) 4 Reply 2 replies @robertfiftysix6304 @robertfiftysix6304 1 year ago Hi David. When you mentioned about dissolving the Resveratrol (i think) in olive oil you said that the oil has a lot of calories & you didn't want to break your fast. Have you any thoughts about Dave Asprey's work - bullet proof coffee in particular in which he says that in a fasted state the calories from the butter / coconut oil etc will not raise blood glucose & therefore not break the fast - rather they are converted into fatty acids & then ketones which are burnt for energy. Thanks for you time. Reply @CassStevens @CassStevens 11 months ago I've purchased Resveratrol that says to take it under the tongue. Will this be effective or does it need to be mixed with some kind of fat like yogurt/olive oil to be effective? Thanks. Reply @eleranalimitless2363 @eleranalimitless2363 1 year ago My body reacts a lot to Metformin. It really disturbs my stomach. Is there anything I can do for that? 1 Reply @tara5742 @tara5742 1 year ago 38:07 was hilarious 🤣 You guys are great Reply @vegancatlady1017 @vegancatlady1017 3 months ago What supplement should I take first 🤣 I purchased a bunch suggested by Mr. Sinclair. I guess I should test it out myself which ones feel better ❤️‍🩹 Reply @casagenarp @casagenarp 1 year ago Thanks for yet another great podcast! After listening to you on the Andrew Huberman podcast I tried supplementing with NMN. Within a week I got severe symptoms of overdose, extreme anxiety and not able to sleep. Nedless to say I stopped taking it immediately. I took 500 mg of NMN (chribubble) each day, I am very healthy and fit and have no underlying illness that I know of. What's up with this? 5 Reply 5 replies @cristinastoyanoff5447 @cristinastoyanoff5447 1 month ago Very thankful for the information it’s awesome Reply @timesharetraveler @timesharetraveler 1 year ago If you can not get Metformin.... Is quercetin plus fisetin in combination a good backup plan.... Already doing resveratrol and NMN. It is hard as a lay person to understand some of the details... Appreciate all of your efforts to reach average people like me. 1 Reply @landonhill4611 @landonhill4611 1 year ago Greatly appreciate this channel, 💙 so forgive me if this sounds ungrateful, but...COULD YOU PLEASE ADDRESS AT LEAST A FEW OF THESE QUESTIONS FROM YOUR VIEWERS? Thanks in advance~ 1 Reply @BooDamnHoo @BooDamnHoo 8 months ago It is because NMN and related supplements are effective that the corporate FDA is looking at banning NMN, etc, over the counter/as a supplement. They want to make sure you have to see a doctor, convince them to prescribe NMN, and then pay through the nose. 2 Reply @crackyflipside @crackyflipside 1 year ago Has there been a comparison between resveratrol and pterostilbene in SIRT activation? Reply @quaterman2687 @quaterman2687 1 year ago The spermidine that can be bought is 1 to 3 mg per capsule. If I want the 1g I have to eat 300 to 1000 capsules every morning 😂 How do you take the 1g ? Can it be bought in higher doses? 4 Reply @davykrieger @davykrieger 1 year ago In terms of taking resveratrol with fat in the morning - would a gram of fish oil (in capsule form) do the trick? I also don't want to break my fast. Reply @susieculley145 @susieculley145 10 months ago Is Berberine a safe trade for metaformin? Thank you for your studies.🍇 Reply @danmustlearn @danmustlearn 1 year ago Resveratrol, 1gram per day, in the morning with yogurt or olive oil,basil, and vinegar (needs fat to be absorbed) Nicotinamide mononucleotide(NMN), 1-2 grams, in the morning with same yogurt/olive oil Quercetin and fisetin, 500 mg each, once per day, in the morning Spermidine, 1-2 mg per day, in the morning Metformin (prescription drug), 800 mg, in the evening 2 Reply @DecibeldB @DecibeldB 1 year ago So interesting, ill be curious to see where it is safe to purchase those supplements Reply @andrija754177 @andrija754177 1 year ago Hi,I dont know if you are going to read my comment or not but I have obligation to give you friendly advice: If your goal is to hit mass audiance and give proven advices/tips regarding longevity that is affordable to majority of people,it would be beficial to put captions/translations in different languages,especially taking into consideration that books of David Sincler are not translated in other languages (for example Serbian/Croatian) and elderly people (like my parents) are not so familiar with English,and this type of podcast would really really make them interested. Please,take it as constructive suggestion that would really make huge impact on your audiance. Great podcast,keep it up guys and I hope you would put Serb/Croatian subtitle/captions Cheers :) 1 Reply @PistolPete7 @PistolPete7 1 year ago So, my question is, if methionine is one of the biggest implicates in aging, does that mean that B vitamins especially B12, B9, B6 also contribute to aging? Since they recycle homocysteine back to methionine? I think it would be a good idea to approach, also taking into consideration that NMN and NR or Just Niacin depletes methyl groups, does adequate methylation increase aging? 3 Reply 1 reply @ExbotHero @ExbotHero 1 year ago (edited) I have one BIG problem with one tiny bit of all this. (Or do I?!) First of all. Love what David Sinclair does. Have been following him and his work for a long time. The problem?! Well, his word is his bond. We trust him to tell no lies otherwise we don't trust anything he says, right?! (This is my fear when I consider his enemy's view.) Once again; The problem: He has never indicated in any of his many interviews that he takes athletics green every morning before they became sponsors here. In fact, he has made a point to say the opposite. "I only take X, Y, and Z nothing else." That's a problem, right?! Why didn't he just say; "I have started to take this recently...?!" (Don't give enemies argument for free, right?!) After all, what he says is actually pretty important when the biggest capital a scientist has is his word. EDIT: I do understand that he could have taken it for years. On top of that, I really don't care if he didn't. A possible small white lie is a bargain price to pay for all this interesting information. Just wanted to point this out from a friend's perspective before any enemy uses it. Preferably followed up with a good explanation (comment) from David taking away all doubt. 1 Reply @dwdwone @dwdwone 1 year ago But how do you prevent the salvage pathwayfrom limiting the available NAD? Wouldn't this mechanism negate any supplementation? Reply @loveallthepeople5017 @loveallthepeople5017 1 year ago Hi David, I am thinking of taking metformin but my doctor is warning me that it might affect my kidneys, I have a history in receiving heavy medication for my bad back since I was a kid, should I be afraid it is metformin safe for everybody? Reply @PianoUniverse @PianoUniverse 1 year ago (edited) Late life >65 metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism as per a paper I recently read. 1 Reply @alicia-hd2cs @alicia-hd2cs 1 year ago (edited) I wonder how much physicians and doctors in general know about the diet…my dermatologist didn’t even believe me when I said i avoid dairy and sugar due to skin issues. She treated me like a brat and said diet has no effect on acne. Top derma in my country and yet a complete gnome.. 2 Reply @catsteinhilb2880 @catsteinhilb2880 1 year ago (edited) I can’t wait until you develop your own line of supplements 6 Reply @sebastianosuch273 @sebastianosuch273 1 year ago David, could you tell us more about how coffee affects our health and longevity? There’s a lot of research telling that coffee has positivos influence. But that’s a big industry and I don’t know if the research is true. To me, coffee feels like a gateway drug to eating more sugar and junk food. Each time I follow healthy diet, shortly after introducing coffee I fall off the wagon and reach for sugar and fast food. Reply @B24CoPilotNiece @B24CoPilotNiece 1 month ago Hi, I’m just now learning about this. I find it incredibly fascinating. I’m Searching for an NMN supplement, most all are just showing up as “nicotinaminde”… can anyone here give a suggestion for a particular brand and quantity? TIA Reply @FlockofAngels @FlockofAngels 7 months ago I recommend peroxide supplements, my "just for men" treatments have knocked 30 years off my old age related illnesses. lol (just kidding) Great info in this video thanks! 1 Reply @yayangtapir4130 @yayangtapir4130 1 year ago Would you please tell what to look for in blood profile to see if NMN is working in the body after having it for a month? 2 Reply @roaminx @roaminx 1 year ago Life Monitoring. Life Changing. Future Altering. Thank You. Reply @catglidden @catglidden 1 year ago So the highest dosage of Spermidine I can find is 10mg. Were you talking 1 gram of pure Spermidine, or 1gm of Wheat Germ Extract (that contains Spermidine?) Anyone having any luck finding this? 4 Reply @suncat9 @suncat9 1 year ago I'd like to know what other supplements David Sinclair is taking if any, such as vitamins (B complex, C, D, and K), garlic, tumeric, CoQ10, magnesium citrate, zinc, beet extract, fish oil, and so forth. Reply @smyazdani @smyazdani 1 year ago Hi David, this is great. However, you haven't talked about Apigenin which is a CD38 inhibitor. Don't you believe that it works? 1 Reply @peggyherron119 @peggyherron119 1 year ago Can you suggest an approximate dosage for Spermidine? Reply @petarpeevski @petarpeevski 1 year ago (edited) Judging by the comments, the most concerning issue is the lack of knowledge on the cancer effect. Yet this was just briefly mentioned. I will watch to see if there are any developments on this. Looks like dr. Sinclair notices issues with increased senescent cell and looks for other ways to keep them down by taking spermidine. Most people lack knowledge to regularly monitor themselves and how to take corrective actions if something goes the wrong way. Looks too early for my taste. Reply @lisaarseneault7453 @lisaarseneault7453 1 year ago Curious about TMG - thought you are supposed to take it if you are supplementing with MNM 1 Reply @Philusteen @Philusteen 1 year ago Dr. Sinclair - I follow another YouTuber named Dr. Brad Stanfield - he posted a rather effective aggregate of resveratrol research that was very persuasive that resveratrol is not just ineffective, but unhealthy. Could you please address? 5 Reply @225amyjo @225amyjo 1 year ago Can you clarify the dose of spermidine? The most I have found is 4mg per capsule... will that be effective? Reply @subnetworking @subnetworking 1 year ago Love your work! Thanks Suggestion: stop telling us what you’re gonna talk about & just talk about what you planned to talk about (rhetoric tip). Just say it🙂👍🏼 it’s good stuff 2 Reply @adrianotorija6514 @adrianotorija6514 1 year ago Great job!👏🏼👏🏼👏🏼👏🏼 1 Reply @quaterman2687 @quaterman2687 1 year ago Don’t you have to take TMG together with NMN? Or are there changes about that? 1 Reply @nigelchia8380 @nigelchia8380 1 month ago Hi, does ozempic yield the same longevity effects as metformin? Reply @susette2024 @susette2024 1 year ago (edited) hello Dr. SInclair, are there any studies and recommendations especially for women regarding hormones, menopause and intake of bioidentical hormons or herbs, or supplements etc. and prevention of diseases related to decline of hormones. I would like to learn more especially about womens health (so rare in the school medicin). Thank you. 12 Reply 2 replies @migtowredpill6950 @migtowredpill6950 1 year ago I'm glad I read "Lifespan", thus I understand much better this conversation Reply @DavidGroff @DavidGroff 1 year ago Assuming the purity level is similar, is there a significant difference in quality/absorption/etc. between resveratrol derived from grapes and that from seaweed? The seaweed stuff is a LOT cheaper... Reply @romatieboodoosingh826 @romatieboodoosingh826 1 year ago God blessing to you Sir Reply @gailkoelmeyer7650 @gailkoelmeyer7650 6 months ago DR. David, what about coconut oil, or coconut milk, and what are all the foods you eat..which veges etc. Thankyou! Excellent Interview. Reply @strengththroughthescriptur9880 @strengththroughthescriptur9880 1 year ago Great content! Reply @DalidaD @DalidaD 9 months ago (edited) People should look into the FDA nmn supplement ban and its connection with Sinclair. 5 Reply @heatherd1583 @heatherd1583 1 year ago No wonder we get hangovers more frequently when we are older. Amazing. Reply @timmorakinyo9529 @timmorakinyo9529 1 year ago (edited) Fasting and excercise is the best evolutionary way to stimulate those pathways without side effects or over stimulating one against another..... I have been doing fasted workout for 5 year now and had my blood work (check all health markers)the result is amazing in term of hormones, healthy guts,energy, clarity/emotions/cognitive enhancement and better sexlife than when I was 20 years old and now over 50year old....We just need to awake our innate evolutionary way of survival and thriving because the intelligent within and without works synergistically. Reply @artemponomarenko8605 @artemponomarenko8605 1 year ago At what age would it be reasonable to start taking NMN and Resveratrol? Reply @paulaaquino5847 @paulaaquino5847 1 year ago Just randomly found you here on yt and into the world of longevity and I'm never going back!! About to buy your book as well! 🙌🙌 Reply @rbrown2217 @rbrown2217 9 months ago Dr. Sinclair, if you have an inability to digest sucrose would you be able to consume Resveratrol? Assuming the capsule itself did not contain any. Reply @MarkDoesYoutube @MarkDoesYoutube 1 year ago 38:15 Best part of the podcast. You're welcome. 6 Reply @user-qy9ys7ux6v @user-qy9ys7ux6v 1 year ago Hello, would NR or NMN be useful for someone in his early twenties? Reply @damianlund395 @damianlund395 1 year ago Thanks for sharing David. Having problems finding resveratrol, lots of trans-resveratrol out there tho. Is trans version any good? 2 Reply 3 replies @HarpreetKaur-dw2me @HarpreetKaur-dw2me 6 months ago Thank you David Sinclair 😊🙏 Reply @whitestolevideos1200 @whitestolevideos1200 1 year ago You don't mention this, but I have read that resveratrol has an estrogenic effect on the body, and that if a woman has had breast or uterine cancer that they would be wise to not take resveratrol. Regardless of that research, might it be ok to take a low 250 mg dose for aging benefit? Reply @krisjay1558 @krisjay1558 1 year ago the other two SIRT1 activiators after resveratrol when CC says "inaudible" are Quercetin and Fisetin if you didnt catch it. Reply @einosky @einosky 1 year ago If you take these supplements, does it reduce your body's capacity to produce them? (NMN etc) 22 Reply 4 replies @hobbyfarmer1452 @hobbyfarmer1452 1 year ago Dr. Sinclair mentioned taking TMG, CoQ-10, Vd, Zinc and Magnesium in other interviews. I have added those to my supplement list. Please clarify so that I can take off if David is not taking them any more. Reply 2 replies @xsilentxhawkx2383 @xsilentxhawkx2383 1 year ago Can resveratrol be taken during first meal breaking fast instead of the morning? Reply @quedav @quedav 1 year ago So I have been doing some research to look at supplements that could be added to my daily regiment and talk to my PCP about. However, can you point us in the right direction regarding the raw supplements? It seems difficult to get 1g of Spermidean or NMN in its raw form. Please assist with finding these supplements for the average person. Reply @Hector-qu9vo @Hector-qu9vo 1 year ago What about those of us with Chronic fatigue syndrome who suffer severe brain fog and cognitive distinction? What’s happening and what do we need to do to fix it? Reply @Manupaya24 @Manupaya24 1 year ago I'm 25. Is it too early for me to take resveratrol, NMN and metformin or is it as safe as for someone age 40? Reply @geoffwelch5952 @geoffwelch5952 1 year ago Correction***- The study referenced for spermidine and cognitive decline was dosed 1.2(mg) not measured in grams. 1 gram has not been studied in humans and possibly be detrimental by over-activation of autophagy in some tissues and cell lines. 8 Reply 2 replies @razalghul9885 @razalghul9885 1 year ago what's the right dosage for Quercetin and Fisetin ? Reply @lyntb3536 @lyntb3536 1 year ago NMN prices seems to have gone way up since about a month... I wonder if it's in relation to the publication of this incredible video ! Reply @desiree4584 @desiree4584 2 months ago Hi :) . I had a question, If I get enough tmg in foods do I still need to take a tmg supplement when taking nmn? Reply @nicolasjardin8507 @nicolasjardin8507 9 months ago Hi Dr David Sinclair . I bought NMN , TMG , Fisetin , spermidine, resveratrol and quercetin . My question : can I take everything the same time the morning or each supplements need to be take by different hours ? 1 Reply 1 reply @susanvonhoene1867 @susanvonhoene1867 1 year ago If you follow fasting (which I do) you will lose muscle mass unless you resistance train. Train in late pm to get benefit from eating dinner and giving body protein. I started supplementing for last two weeks. We will see. Anyone notice any changes? 2 Reply 1 reply @jaihanjqx1140 @jaihanjqx1140 1 year ago I have been taking resveratrol for several years now. Unfortunately I am confused. Many evidences suggest on the contrary. Why doesn't Dr. Sinclare clearly answer the question raised by Dr. Brad Stanfield. I think there are many worried people around the world who have been taking resveratrol waiting for Dr. Sinclair's response. Please! 12 Reply @roblowry5252 @roblowry5252 1 year ago I noticed that some NMN is sold as liposomal, other brands don't mention it. Is there an advantage to the liposomal version of NMN? 2 Reply 1 reply @barbaralanzante5619 @barbaralanzante5619 1 year ago Dr. Can you profess on hormonal replacement therapy? Is this an Interference with longevity? Do you recommend, Rather would you recommend it for a family member or yourself rather? Forever thankful Reply @catsworld8055 @catsworld8055 1 year ago Very good informative video .sir how to deal with EA diseas what's your opinion pls reply Reply @erwinrogers9470 @erwinrogers9470 6 months ago Love it/Great information 🔥 Reply @josephpetrosso4178 @josephpetrosso4178 1 year ago Dr. Sinclair, thank you for tremendous info you've given us,. Can you tell me if you have done any research on the company Viome ? your thoughts Reply @lotfibouhedjeur @lotfibouhedjeur 1 year ago I wait for these videos as if my life depends on them. Wait, it does! 4 Reply @plantbasedathleterealtor6145 @plantbasedathleterealtor6145 1 year ago Excellent! Please make a podcast about HLAB27 💫🙏🏻 Reply @jordistulen4565 @jordistulen4565 1 year ago (edited) In our country they sell Resveratrol in combination with Bioperin(Peperin extract), do you maybe have an opinion in this? 1 Reply @christinem367 @christinem367 11 months ago I've been doing some research... So this regimen, which sounds amazing and so compelling, is pretty pricey... I am curious: how much/month do you folks pay for following this path? Wih my calculation (what is available - given i am not sure its fairly good quality but i am HOPING- it come around a minimum of 500$CAD/month. Are these molecules so expensive to produce? Is it the hype of Dr Sinclair that brought a whole new price cosidering the demand/offer powerplay? NMN in Canada is about 100$/month (not even sure about the quality)... Anyways. I am having a hard time wrapping my brain around this monthly amount. Talk about health equity... Reply @blackrain87 @blackrain87 1 year ago Can the NMN be put in the Yoghurt together with the Resveratrol as well? 1 Reply @splathub @splathub 1 year ago I take Quercetin to combat histamine - wonder if Fisetin does the same 1 Reply @PA-eo7fs @PA-eo7fs 1 year ago What age would you recommend a person begin? Also, are there negatives to microdosing, say 2-3 days on, take a 2 weeks off, back on for 2-4 days , 1 week off. I am 28. 4 Reply 3 replies @afterdark6822 @afterdark6822 1 year ago Supposedly pterostilbene is superior in terms of absorption. I am curious in regard to NR and senescent cells. Reply @SusanAllen-sn3mx @SusanAllen-sn3mx 1 year ago Taking the NMN with a fatty product is noted. Seems like I heard somewhere, on this or a Huberman lab podcast where This topic was reviewed, that the NMN can also be taken with protein (such as a protein shake w Minimal carbs). Hydrophobic yes, but must it be taken with a fat or can NMN and Resveratrol be taken with a protein? Then, how long must this digest before liquids can be used? Been waiting 30 minutes since I am not yet using regular intermittent fasting although I am trying to work out a daily schedule for taking supplements, regular prescription, meals, exercise. Reply 1 reply @sbach6242 @sbach6242 2 weeks ago Hello Dr. Sinclair. Thank you for all you do. May I please ask if you still make and take bravo yogurt? If so, may we please get the recipe? Thank you!n 1 Reply @RedEventsIreland @RedEventsIreland 1 year ago David mentions that resveratrol should be taken with fat such as yoghurt/ olive oil. I have ordered tablets, in this case, can I just swallow them with water or should I open the capsules and mix with yoghurt for example? Reply @giraffeasaurus8643 @giraffeasaurus8643 1 year ago Thanks for everything Doc 2 Reply @Michael-zc3bi @Michael-zc3bi 1 year ago Any thoughts on the phytochemical sulforaphane? 5 Reply @Diana-wi6yr @Diana-wi6yr 1 year ago (edited) 1:08:00 dr David's morning to night supplements schedule Reply @poppyflower7873 @poppyflower7873 9 months ago Do any of these supplements cause clotting in people with cardiovascular serious problems already? Would love to reverse aging, cosmetically speaking, but don't want to end up just a better looking corpse. Also, have poor absorption of fat-soluble supplements and food, in general, due to long-standing ileostomy issues. Just found your podcasts.......very happy! Reply @pansyjordan8653 @pansyjordan8653 1 year ago Would you PLEASE recommend a NMN/Resveratrol that is pure? I have been experimenting with different brands and not confident of purity. Reply @omerozvardar8545 @omerozvardar8545 1 year ago If I take NR, is that also 1g per day? Also, there are many manufacturers of NR, is any particular one you can recommend? Thank you. Reply @WhereNerdyisCool @WhereNerdyisCool 1 year ago Can Dr Sinclair address the Resveratrol/Pterostilbene battle that's going on from Dr Brad Stanfield? As an observer, I'm confused how David says X and Brad says YYYYY To take or not to take? 2 Reply @02ity @02ity 1 year ago Please provide all the funding sources that have enabled you to get to this point and if this promotion has been influenced in anyway by those funding sources. This includes the CCP, GlaxoSmith, and Gates Foundation funding for this podcast series, Lux Capital, Sirtris Pharma, and Genocea Bioscience, and affiliated Cambridge Research. 11 Reply 2 replies @Robert-cd5zr @Robert-cd5zr 1 year ago Would sulforaphane / avmacol or hyperbaric oxygen therapy have beneficial or protective effects? Reply @gospelofthomas77thpearl81 @gospelofthomas77thpearl81 1 year ago Very interesting- thanks 👍🏼 Reply @charlesx1957 @charlesx1957 1 year ago Took me a year to have a intelligent talk with my physician! Lol 1 Reply @dannycashman8446 @dannycashman8446 7 months ago question if anyone knows? in regards to MNM helping with jetlag, I work nights and was wondering would it be better to take the NMN when I wake in the afternoon? Reply @josusantamaria5370 @josusantamaria5370 7 months ago Nice podcast. What about Urolithin A? Can you comment on that? Reply @TateisGodsfavorite @TateisGodsfavorite 1 year ago Hello David, could you start answering 5-10 questions from the comment sections? It’ll really get the viewers involved, thx:) 3 Reply @nic4666 @nic4666 6 months ago I love the dead eyes that Dr Sinclair gets as soon as he starts reading the blurbs from the advertisers. Reply @BucketWheat @BucketWheat 7 months ago (edited) Just curious about Spermidine... does the sperm need to come from the same organism as the recipient ? (Mouse sperm for mice, human sperm for humans, etc.) And how would you withdraw sperm from say, a worm, for example... ? Can Berberine be taken together with Metformin? I already have a 'continuing prescription/ for metformin of 2 per day, of 1,000mg each... My last A1C was 5.5, largely due to diet changes. (My Blood Glucose was over 400 after COVID-19 infection and recovery, and A1C was over 7.0) So I have been on a more 'planned' diet and 2 Metformin {2,000 mg per day.} I will be 71 in April, and except for gray/white hair, most people guess my age around 50... Reply @natalyamarcus3165 @natalyamarcus3165 1 year ago Does anyone know which company David advises for spermicide supplements? Thank you! Reply @darkninjaguyman @darkninjaguyman 7 months ago So are the molecules just mimic these stressors to maximize a normal health span, or are they actually making it longer? So if you’re already doing everything else to optimize your health are these supplements still showing an increase in life span? Reply @ashkanentesari2254 @ashkanentesari2254 1 year ago Dr. Sinclair can you please tell us how to find good quality NMN? So many brands out there but unclear testing. 2 Reply @JoeCool0510 @JoeCool0510 9 months ago It's a real shame about the FDA's stance on NMN. Here is something that could help a lot of people, is relatively safe (correct?), and now it looks as though it will no longer be available OTC. Is this fair? Why publish books and podcasts about this wonder molecule if it isn't going to be available to the masses -- unless they can convince their GP (who maybe had one class in nutrition and is already skeptical of supplements) to write a prescription-- also by which time the price will be extraordinarily high! 3 Reply @EzioMineccia @EzioMineccia 1 year ago It would be nice to know the brands of the supplements Reply @toddbloom6930 @toddbloom6930 11 months ago I haven't seen where you discuss N-Acetyl-Cysteine (NAC) with respect to mitochondria boosting ... what are your thoughts on this supplement? Reply @monahanalla5160 @monahanalla5160 1 year ago Can I still take NMN if I had severe allergic reaction to Niacin? Reply @lauramakin834 @lauramakin834 1 year ago Hey David ! just wondering, what are your thoughts on HRT? 2 Reply @stephenlucier @stephenlucier 1 year ago Looking forward to next week! Reply @qianning3940 @qianning3940 1 year ago Dr. Sinclair said that he take 1 gram of Spermidine every morning and I bought the SpermidineLife ( Dr. Sinclair is the adviser of the company) which contains ( 2 cuspules recommended) 800 mg of Wheat Germ Extract. So I asked their costumer service about the discrepancy. They told me that Dr. Sinclair has misspoken about taking 1 gram , it should be 1 mg. Their 2 cuspules contain 800 mg wheat germ extract which equates to 1 mg of Spermidine. Hopefully someone can comment on this to clear the confusion for me. 3 Reply @viu2011 @viu2011 10 months ago I was curious which brand is most recommended for NMN and reservatrol. Does anyone have any recommendations? I see we aren’t to self promote but there are so many different brands online. Thank you I’m advance for any insight. Reply @sanchez911 @sanchez911 1 year ago Since NAD levels start to shrink in age does it make sense to start NMN with 30? I mean if my NAD level is still full it does not have an effect, right? Reply @stanthompson9379 @stanthompson9379 1 year ago Dr. Brad Stanfield was only following the most recent research and trying to clear up this supposed “misinformation” about Resv. He looked up to David and kept trying to get David involved for his input or a discussion. You can tell Brad is a gentle soul a truly remarkable good human being the kind of person who is extremely rare, I am in disbelief in regards to the video he just put out saying David Sinclair blocked him you can tell the poor guy is ready to cry in his video David you broke his heart and you conducted yourself like a spoiled child. I’ve always had a ton of respect for you David but after what you did to Brad I have lost all my respect for you and now doubt anything you have to say. If you genuinely believed in your work and what you say then you would have had no issue having a debate with the man but not only did you not have a debate with him but you went out of your way to even block him. I no longer have any respect for you David you literally acted like a spoiled brat by doing that. It just shows the kind of ego you must have. The truth is out David Sinclair only cares about making money. Shame on you David. Reply @briangill23 @briangill23 1 year ago Is there an update to the NMN studies being done at Harvard? Reply @nadioluk @nadioluk 1 year ago Thank You Dr David Sinclair. Reply @penmaenmawrdefiant1146 @penmaenmawrdefiant1146 1 year ago I have a question. How does histamine in the body and brain affect aging? Should we aim for low histamine levels? I note resveratrol and quercetin lower histamine levels. Is this significant? 18 Reply 3 replies @alanshulman8328 @alanshulman8328 1 year ago can I substitute "fish Oil; omega 3 fatty acids) for yogurt or olive oil as a fat with resveratrol for absorption? Reply @cryptotwitter @cryptotwitter 1 year ago Can anyone summarise what we should have on the daily or every other day. And the links to purchase the compounds? Reply @elsa.bernalamaya6656 @elsa.bernalamaya6656 1 year ago Me interesan sus videos pero en español.Gracias Reply @roberteng768 @roberteng768 1 year ago Is trans-pterostilbene a good substitute for the non-soluble resvatrol Reply @chinemeremohaeri9100 @chinemeremohaeri9100 8 months ago My antipsychotics are probably extending my lifespan. They slow me down incredibly. Reply @umityayla5051 @umityayla5051 1 year ago I just want o ask a simple question. Does metformine lower testosterone ? If so, how come it does not generate any problems ? 3 Reply 1 reply @lauried4439 @lauried4439 1 year ago What is dosage of NMN and resveratrol per lb or kg for dogs? Reply @chrtravels @chrtravels 1 year ago It’s funny that because of legal issues you have to say consult a physician when most doctors are not going to know anything about this kind of thing. It would be nice if this is something you know about to go into what considerations you might want to take into account. For example are there specific cancer screenings that would be recommended and things like that. 1 Reply @littlevoice_11 @littlevoice_11 1 year ago Please can you cover the topic of exogenous ketones in the future? Reply @dawnestes6794 @dawnestes6794 1 year ago Can you take the athletic greens in the morning and it still be considered fasting? Or does that break the fast? Reply @danielebattistelli8725 @danielebattistelli8725 1 year ago I hope to live enough to watch all the episodes Reply @scottk1525 @scottk1525 1 year ago (edited) I sure wish that David would take the time to address Brad Stanfield's concerns about Resveratrol, namely that its efficacy as a Sirt-1 activator and/or longevity molecule has yet to be reproduced (even by the ITP,) and that it may even be harmful. Brad's been making videos and tweeting Sinclair about this for months (years?) And instead of responding to these concerns appropriately, all David can muster are dismissive, passive-aggressive tweets. Maybe this discussion is settled in David's mind, but for us normies, clarification is needed, and it seems like David is being evasive on the topic. 12 Reply 2 replies @arlenebitmansour4838 @arlenebitmansour4838 1 year ago What are some of the best supplement brands for NMN? Reply @robinstuart8941 @robinstuart8941 1 year ago Does Spermidine accumulate in the body when not ejaculating for a prolonged period of time? Kind of makes sense that no sex, like calorie restriction, is a signal to the body that times are tough. Maybe limiting ejaculation is an alternative to buying supplements HAHA Reply @user-wl4sl1ty5h @user-wl4sl1ty5h 1 year ago Dr.Sinclair, Is it ok that I take nmn? I long for taking it everytime I see your video. I had a complete remission after chemotherapy for a lymphoma. It has been 10 years since I had a complete remission. Please answer my question. Reply @lubo955 @lubo955 1 year ago I just received my resveratrol (1000 mg) but the color is yellow. The product is best to use before 05/2024. The ingredients are: Resveratrol, Microcrystalline, cellulose, Carboxymethyl, Starch Sodium, Magnesium, Stearale, and Black pepper extract. Do you think that this product is good to use? Reply @zack7smithey @zack7smithey 1 year ago Creatine lends a phosphate to ATP during exercise, increasing endurance. Are there any studies taking NR/Vit B with creatine to see if the same is true with phosphate lending? Reply @redart3005 @redart3005 1 year ago which supplement companies does he recommend? I know he said he doesnt endorse but which ones are trustworthy? 7 Reply @manologv1852 @manologv1852 1 year ago Creatine is supposed to increase ATP deposits. Does it affect to AMPK pathway, by reducing its effects on creation of more mitochondrias? Thanks. Reply @rogerfarwell4837 @rogerfarwell4837 6 months ago What’s your thoughts on some of the studies on metformin in conjunction with HGH? Reply @magz0x177 @magz0x177 1 year ago can you take nmn with quercetin and fisetin all at same time ? Reply @goncalves_luis @goncalves_luis 1 year ago I know Dr. Sinclair does not want to be associated with any pharmaceutical company but it's in everyone best interest to know what companies/laboratories/brands are of really good in order to avoid injesting low quality products and instead of improving it goes in the exact opposite. I once ordered Tru Niagen, which at the time it smeed a good brand, but i really have no idea. So, does anyone really knows which laboratories produce good quality NMN and such? Reply @bekithomson5200 @bekithomson5200 1 year ago I wonder about the safety of these supplements in seniors and in combination with other drugs. The manufacturers are not motivated to study the effects in humans. I'm in a rapamycin trial that doesn't give anyone rapamycin, but just compares users to non-users. Reply @zbridgjpxupzm @zbridgjpxupzm 1 year ago We really need a straight forward list of supplements to take. otherwise this is just a thought exercise for scientists... 4 Reply 1 reply @kritiisood @kritiisood 9 months ago Is it also beneficial/ preventive to start these supplements in your 20s? Reply @lauriemeunier567 @lauriemeunier567 1 year ago David are you pulsing resveratrol like studies have shown that it is better to take resveratrol every other day? 1 Reply @marinafoglietti9351 @marinafoglietti9351 1 year ago (edited) Dr. Sinclair I have heard that resveratrole is stressing the cells, is it true? Could it cause arythmya? Another question, if Resveratrol is not white is it functioning anyway or not? Reply @zoyapawlowska6142 @zoyapawlowska6142 1 year ago NAD+ metabolism can regulate the pro-inflammatory SASP, thereby promoting tumorigenesis, as shown in 2019 (Nature Metabolism), when mice treated with NMN showed increased cancerous lesion - please comment @David A. Sinclair Reply @bretsnoke9213 @bretsnoke9213 1 year ago David, have you heard of 5 amino 1 MQ? Looking to take for my diabetes 1 Reply @sonnymatthews5452 @sonnymatthews5452 1 year ago How much quercetin should you take a day? Should you take Resverotrol every day? 3 Reply 1 reply @hailedawitsolomon9998 @hailedawitsolomon9998 6 months ago 8 years ago l am type 2 diabetic patient and ketosis and treated under ICU beds. After clear the ketone levels, l started take insulin for one week and drop the sugar level dramatically. Then my doctor prescribe to take metformin 1000mi per day for 2 week's and my blood glucose levels had been normal . Then With out the permission my doctor l stop taking the medication until know almost for 8 years. and I am checking my glucose levels every 3 days, but the result is 95 - 105 . What is the reason? Reply @jeffmiddlebrook5251 @jeffmiddlebrook5251 1 year ago How much phosphate needs to be added to NR if you would to take 1g of NR daily? Reply @gwynerskine6853 @gwynerskine6853 7 months ago I have your book doc and I've read it off and on for the last few years the one thing that I did decide to take was the reserve toll however you say that however I've taken vitamins all my life I do not take any kinds of prescription medicine and I'm headed for my 82nd birthday for me I'm like how much longer do I want to live I mean I guess I'm pretty healthy pretty lucky but emotionally the way things are going in the world it's tough for an old folk Reply @user-fq4on5st4p @user-fq4on5st4p 4 months ago (edited) The question I really need a answer to is: If you take NMN for 1 month and stopp taking NMN, does your natural production go back to normal ? If you take NMN for 1 year and stopp taking NMN, does your natural production go back to normal ? What I wonder about is that if you take NMN, will your body restore your natural production if you at some point stop taking NMN, will everything go back to normal ? Could you make an official announcement about this? The problem is if your body dont restore its natural levels after stopping NMN you will be fatigued and age faster. 1 Reply 2 replies @uvuwuewuewueonyetueosas227 @uvuwuewuewueonyetueosas227 1 year ago is it ok to take onlu 100mg resveratrol per day but for a extended period? i dont want to go for a higher doses, or its better to go for 300mg ? 1 Reply @domingosponces9303 @domingosponces9303 8 months ago It seems you can’t buy NMN in the US because this “gentleman” wants to patent it and make money with a natural substance, there is always an weasel where you less expect! 4 Reply 1 reply @edwardbachman9135 @edwardbachman9135 1 year ago (edited) NMN taken just once per day? The current packing of a popular NMN product instructs 2X/day (and if I recall, it used to say 4X/day). Can someone explain what is optimal? Reply @tempname882 @tempname882 1 year ago What about Apigenin? Has that proven to increase insulin sensitivity? Reply @assassino1974 @assassino1974 10 months ago hey,I train almost every day or swim 2km slowly or do 40 minutes of aerobic exercises, I can't understand what are the contraindications of resveratol and metformin if taken the night before ??? I understood that it is not recommended but it is dangerous for health or only affects performance Reply @timandersen8030 @timandersen8030 7 months ago Is the delivery of 3 yamanaka genes - Oct4, Sox2, and Klf4 (OSK) to the body better than taking any of these supplements? Reply @heatherd1583 @heatherd1583 1 year ago I’ve been very curious about a family member. She eats all the wrong food and way too much of it and she smokes. I am a nurse practitioner and I own a wellness clinic and medspa. I look at skin all day. This family member is not aging. Her mother aged horribly. I think it’s the metformin. Again she has the worst diet and she smokes. She doesn’t use any retinol or skin care. 😳 she doesn’t get Botox or anything and I know this bc I live with her. Reply @LindyPureResearch @LindyPureResearch 1 year ago I am so glad you are doing these podcasts....I have been following you David for over 2 years now and am on the NMN/Resveratrol and Berberine protocols. I love how I feel and look, my doctor is amazed and so are the other people when I tell them my age. Also been doing the fisetin and quercetin as well. And a glass of red wine at dinner. Trying now to cram 2 small meals into that 8 hour window. Blessings. 3 Reply 2 replies @tilmansillescu6870 @tilmansillescu6870 1 year ago I wonder why Apigenin was not mentioned. Doesn’t it in a way extend lifespan as well? Reply @jennyofcoldstone3598 @jennyofcoldstone3598 6 months ago Do GLP-1 medications have the same positive health affects on the body that Metformin does? Reply @jostarrrrrr @jostarrrrrr 1 year ago Hi David, I am a huge fan !!! I need help with sourcing NMN from a reputable company as I found some reports and articles that don’t actually contain NMN … But I also have heard you mention on many conversations before you don’t disclose that information… any clues at all lol! 1 Reply @clementhoh4430 @clementhoh4430 2 months ago Hi David, can we take NR and phosphate to get the results as cheaper solution , if yes how many mg? Reply 1 reply @Divinelotustea @Divinelotustea 1 year ago I'm wondering what the best NMN product. Which one does Dr. Sinclair take? Reply @petedawson5875 @petedawson5875 1 year ago Anyone know if David talks about visual aging? Like skincare and such - or only lifespan? 3 Reply 4 replies @ginkgoway8165 @ginkgoway8165 11 months ago For someone on ketogenic diet I assume metformin is not necessary or taking Quercetin during exercise won't be an issue. am I correct? Reply @irinadiamant3812 @irinadiamant3812 1 year ago Mind blowing! Unfortunately my doctor never heard of this. How can I make sure I’m not killing myself?! Reply @romescala_aban3125 @romescala_aban3125 1 year ago Nice to know pls more substation on these substances mentioned In a microscopic scale...what about on a macroscopic scale of the individual? Reply @Keith-if6zv @Keith-if6zv 1 year ago I didn’t notice him mention TMG. I thought he recommended that to be taken with Resveratrol. 1 Reply @vt1707 @vt1707 1 year ago Hi, can i take NAD with cipralex (escitalopram) ? thanks Reply @rashadaliyev2674 @rashadaliyev2674 1 year ago Please provide a public response to Dr. Brad Stanfield on Resveratrol. Dr. Stanfield has presented clear evidence of later studies that suggest that Resveratrol does not have the effects you claim, and could actually be harmful. After this much advertisement of Resveratrol, it is your duty and responsibility to clarify the issue in detail. If Dr. Singclair does not respond, it only makes everyone more suspicious of him advertising Resveratrol for personal financial gain. I hope it's resolved soon. 3 Reply @danielmunch9555 @danielmunch9555 1 year ago Thanks for this excellent episode again! How do you take 1g of spermidine in the morning? I think the company that you are advising is spermidineLIFE, where I actually got my spermidime from. According to the label you should take 800mg of wheat extract which is just 1mg of spermidine per day? And also they say you should take it anytime with food. I guess my question is: Do you take 1g of wheat extract (2.5p tablets) and why in the morning (I do fast until 1pm)? Reply 1 reply @jasonreardon8620 @jasonreardon8620 1 year ago Is there a reason to take NMN and Resveratrol together? If one is practicing time restricted feeding, would it make sense to take NMN first thing in the morning and wait until breakfast to take the Resveratrol? Reply 1 reply @bethpulliam803 @bethpulliam803 1 year ago Can you take these anti aging supplements along with HGH secretagogue peptides? Reply @noonecaresaboutgoogle3219 @noonecaresaboutgoogle3219 1 year ago Is there any point buying expensive resveratrol if olive oil does the same thing? I've never seen this really addressed. Would you have to ingest a huge number of calories in olive oil to have the same effect? Reply @carbongap5423 @carbongap5423 1 year ago Does Metformin affect people with Gilbert syndrome? What should be avoided? Reply @akhisalaam @akhisalaam 1 year ago I can't believe this is free content 8 Reply @smarthalleck3233 @smarthalleck3233 1 year ago Hey guy’s I love the in-depth, however what about vitamin supplements. 304 says D3 and K2, but how much? I also read somewhere Alpha Lipoic Acid but again, how much. What other vitamins should we be considering. I’m drinking AG1, taking 1G NMN and Resveratrol daily and loving it but I’m looking for as complete a package as I can afford. I’m 76 years old and I great shape due to good diet, running, yoga and qigong. Please advise… Cheers 🤡🤡🤡 Reply @zizimackinnon4147 @zizimackinnon4147 1 year ago Is there a way to get printed notes from this podcast? Reply @crystalsiercks7972 @crystalsiercks7972 1 year ago Can I get a list somewhere and where to get them I know there are many different brands and are not created equally. Thank you Reply @rlwings @rlwings 1 year ago (edited) My depression suddenly disappeared the moment I found out that I could extend the life of my fruit flies! :) Reply @jefflogan3994 @jefflogan3994 11 months ago Question: can I get enough spermedine from wheat germ itself? Reply @zbridgjpxupzm @zbridgjpxupzm 1 year ago "Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men" any comment on this study? 3 Reply @krayziez @krayziez 1 year ago Has anyone tried these supplements yet? Did you feel better with more energy? (Assuming you understand how placebo effects work). Reply @neves0001 @neves0001 1 year ago Hello besides yogurt and olive oil what can we mix the Resveratrol with. is avocado fatty enough? Reply @radic888 @radic888 1 year ago Can you take resveratrol just as a capsule? Reply @j.w2026 @j.w2026 1 year ago Polygonum cuspidatum does sound like a magic spell, LOL very humorous, thank you for that! Reply @user-bu9fw2fs9f @user-bu9fw2fs9f 1 year ago What happenes if you then stop taking NMN? Will the body have lost some ability to create it on its own? Reply @sandrakillalea1150 @sandrakillalea1150 1 year ago @DavidSinclair You probably are aware that on another channel, Dr. Brad Stanfield, your research, findings, and conclusions on resveratrol are being called into serious question. He is presenting data in a very compelling way and many people are rushing to judgment about you and your motivations. I feel there are grey areas not covered/explained though, and perhaps for your reputation and the confidence of your “followers”, it would behoove you to address him or at least his assertions directly on a public platform. Yes? 7 Reply 1 reply @tatumwilliams4896 @tatumwilliams4896 1 year ago I have some wonky genetic pathways mthfr & compt and before finding your podcast I tried NAD supplement. This and also the glutathione supplement - even the slow release version - has the effect that it puts me on edge and made me irritable ? I don’t see this reflected on any searches that I do. What would be the possible cause? I have just started with the NMN starting at a 250mg dose to test.. Reply @TomBillstein @TomBillstein 1 year ago One gram (1,000mg) of Spermidine is very hard to source. Any suggestions anyone? Most Spermidine products have just 3 to 10mg, with the balance being wheat extract or another "filler". 2 Reply 1 reply @vadymkodryan3974 @vadymkodryan3974 1 year ago Can anyone suggest reputable makers of powdered MNM and resveratrol? Reply @susanvonhoene1867 @susanvonhoene1867 1 year ago Will bullet proof coffee (butter, MCT) interfere with glucose or effect fasting? Reply @happiness8328 @happiness8328 1 year ago High David if you had to take one supplement out of everything you take what one would it be thanks ? Reply @bicycleseatthoughts4405 @bicycleseatthoughts4405 1 year ago Please, would you explain why so many resveratrol products are brown and why I’ve heard Dr Sinclair say only white or off white resveratrol is good. Thank you, always, thank you! 3 Reply @geraldtong4414 @geraldtong4414 1 year ago Good day Dr Sinclair, it is possible for you to do an episode on future age reversal technologies like medicine, Nanotechnology and Gene Therapy, descript the treatment and possible timeline these treatment will be available. How it will affect our normal social norms like marriage and reproductive age....................... Reply @sensivityable @sensivityable 1 year ago I heard that metformin as well as other glucose lowering drugs may lower libido too. Is this true? @David Sinclair 1 Reply @mariatrimboli3467 @mariatrimboli3467 9 months ago any side effects with nmn ? and what time of day is best ? Reply @MrIWroteThat @MrIWroteThat 1 year ago Good information in between all the mentions of Harvard. Reply @whitestolevideos1200 @whitestolevideos1200 11 months ago What can you say about the reports that any woman who has had cancer of the uterus should not use resveratral.. Thank you for sharing anything you know on this research Reply @tosvarsan5727 @tosvarsan5727 1 year ago (edited) What about taking resveratrol with MCT oil in the morning fasted? 5 Reply @bebelives @bebelives 9 months ago Have you seen the REDUCE-IT study? Study has shown 30 percent reduction in MACE. 8000+ person study done over 8 years in 11 different countries but Nevada judge (Judge Du) negated Amarin Corps patent (total BS in my opinion) and the generics have entered the market and now Amarin will not advertise the drug. I think this study had a lot to do with a reduction in inflammation (which I think is super important with staying healthy). I would love to know Dr Sinclair's opinion on this study. Reply @marcosvandam @marcosvandam 1 year ago I put resveratrol in a glass of water and it floats to the top. It is very hydrophobic, but it floats! Reply @mcgragor5042 @mcgragor5042 1 year ago I wonder how D-Ribose compares to NR? 1 Reply @davidblaney2024 @davidblaney2024 7 months ago Would love to know a trust worthy source for NMN or NR discussed here. Reply 1 reply @macomemaco @macomemaco 1 year ago (edited) The only available NAD product that I could find here in Italy is NADH, is that beneficial as NAD is? Reply @peterjurt3238 @peterjurt3238 1 year ago (edited) What about TMG along with NMN? 4 Reply @coman349 @coman349 1 year ago This is great and all, but where can we get these anti-aging supplements without fear of getting bad product? Is there reliable source? Where do you get them for yourself? Reply @joeatwork77 @joeatwork77 1 year ago Dr Sinclair, have any of the studies showed a link between bone hardening and epigenetic age? In the sense that it seems implied by what I've heard & read that these different regiments (exercise, diet, sleep, supplements) could prevent the hardening of bones due to age, but is there any evidence that the reversal of Dr Hovath's age grade will in addition reverse the bone hardening due to age? Reply 1 reply @IonasIon @IonasIon 1 year ago Where can we find these substances? Is there any suggestions for products for the general public? Reply @danettedarbonne1804 @danettedarbonne1804 1 year ago What is a good brand of resveratrol to take? Thorne has ResveraCel® and PolyResveratrol-SR® . Any ideas? Reply @rolfet9 @rolfet9 1 year ago I have read that metformin for anti-aging purpose shouldn´t be taken by elderly, but why I do not know. Could this be true? Reply @lizmallen3461 @lizmallen3461 1 year ago Anyone know if berberine can be divided into 500 mg in am and 500mg in pm? 3 Reply 1 reply @SupeHero00 @SupeHero00 1 year ago Does NMN supplementation reduces the bodies natural production of NAD? Reply @GroupRoberts @GroupRoberts 11 months ago Your guidance is to get white colored resveratrol. Can you identify for me which brands are white. The one I just bought was brown when I opened the bottle. I know you don't like to make recommendations, so maybe list several that you know are the good white variety. Thanks a million. Reply @ChrisSmith88love @ChrisSmith88love 1 year ago Metformin is available without Prescription in Mexican Pharmacies. Reply @samitach5685 @samitach5685 1 year ago What’s your take on TMG and ALA.And how do all these molecules interact with thyroid supplements. 1 Reply @andreakferrara1977 @andreakferrara1977 1 year ago What about take metformin every night while on TRT dosage? (170mg/week) I didn't have noticed any energy suppression! Thanx Reply @elensayista8988 @elensayista8988 1 year ago Chamomille + cinnamon tea>metformin. Prove me wrong. Been waiting for you to address this David! 4 Reply @ritaandreeva @ritaandreeva 6 months ago The time posted is 11 months ago, but it must be a much older video because Dr. David said he was waiting for some study results hopefully in 2022. So when was this interview filmed really? Reply @JenP2776 @JenP2776 6 months ago I still believe that berberine is a more safe alternative to Metformin with fewer side effects. Reply 1 reply @justinfuruness7954 @justinfuruness7954 1 year ago What do you take specifically for NMN Reply @himanshusingh3891 @himanshusingh3891 1 year ago what is minimum age for consuming these supplements, I am 17 and want to start this as early as possible, doing IF for past year and exercising, cold exposure and everything physically possible and I want to take it to next level, can anyone help me? 2 Reply @bdoctorg4571 @bdoctorg4571 8 months ago is there anyone that can help me break this down? i am a canadian who is buying trans reservatrol and Arcwell NMN (Nicotinamide Mononucleotide) 250 mg, i am wondering if i need a nad booster and we cant get metaformin without a prescription in canada so i am wondering if i can just add that to my regular vitamins or do i need the nad booster? Reply @Philusteen @Philusteen 1 year ago So, I have a capsule form of NMN combined with Resveratrol; Do I need to break the capsules open and mix them with fat, or can I just take them with my Omega3's?! 6 Reply 5 replies @lifeisgood1221 @lifeisgood1221 4 months ago What is Dr Sinclair's take and experience on ozone treatments ? ? Reply @paufontanini @paufontanini 8 months ago At which age is recomended to start use Resveratrol? Reply @seasons8bit @seasons8bit 9 months ago Would these supplements be recommended for people in mid-late 20s? Reply @stevepaulsen6987 @stevepaulsen6987 1 year ago I know you won't recommend specific manufacturers but can you give an idea of how to find quality sources? 2 Reply @parsapalsami2242 @parsapalsami2242 1 year ago Is there any natural food source containing NMN? Reply @geromefischer9795 @geromefischer9795 1 year ago I’m a simple man. I see a new Video from Dr. Sinclair and I immediately hit “like”. 59 Reply 5 replies @dipeshkkarn953 @dipeshkkarn953 6 months ago (edited) I just got my first - Trans-Resveratrol 1000 - by ProHealth. And it's light green in color but David says it should be white. I bought it from ProHealth only after thorough research, but I feel disappointed as it is not white. Shall I throw it because it is not white, but light green? It's not brown either. It was shipped to me to Dubai, could be due to the distance it had to travel to reach to me ? Please help. Reply @JuliMoodyStunts @JuliMoodyStunts 1 year ago If you inject NAC twice a week do you still need to take NMN ? Reply @valerie4975 @valerie4975 1 year ago Bought some AG with you affiliate link today! Thanks for all the info! Reply @oliverhenning8758 @oliverhenning8758 1 year ago Does anyone know if David Sinclair still takes Aspirin on a regular basis? Reply @ScottHellerTV @ScottHellerTV 1 year ago Can NAC be a dangerous supplement? Reply @karmafairy351 @karmafairy351 1 year ago Dr. David Sinclair looks really young 5 Reply @sciencensorcery @sciencensorcery 1 year ago Can you clarify: with the resveratrol & berberine, when you say take it with food, do you just mean take it at the same time as food? Or is it necessary to mix directly into food as you've described doing with yogurt, etc.? Is it effective to just take a capsule and then eat a tablespoon of yogurt? Also, regarding the effect of berberine on exercise, what if you work out and then take the berberine? Will it still inhibit the muscle growth that happens during recovery, or does it only affect your performance DURING exercise? Thanks so much! Reply @VaillancourtLJ @VaillancourtLJ 1 year ago I like fasting but was told by my MD and naturopath that women during child-bearing years should not fast more than 16 hours because of it's detrimental effects on our reproductive hormones. I can say that when I did OMAD I felt good but never got my period. So it's unfortunate that women cannot take advantage (to the same degree as men) in this anti-aging tactic. I'm also curious how you are able to meet your daily protein requirements on a mostly plant-based diet, because common plant sources of protein (pea, legumes, lentils, chickpeas, etc.) still don't have as much protein per gram as meat sources. Lastly, where does one get access to metformin in Canada? 1 Reply 4 replies @yannlang4849 @yannlang4849 1 year ago Well hello professor, are you going to release your rejuvenating solution next year? Greetings Reply @abelardooquendo378 @abelardooquendo378 1 year ago Hi David, there seems to be some confusion with the info you are giving on Spermidine. Everywhere I’ve looked it’s measured in grams not milligrams, even the highest dose supplements offer 8mg a day. How come you are taking 1 gram? Thanks! 2 Reply @sherripenkacik929 @sherripenkacik929 1 year ago Can resveratrol cause thyroid problems in certain people? Saw a PubMed article that was worrisome. Reply @delaneyondreams @delaneyondreams 1 year ago "Consult with your doctor, Do this or that under your doctor's supervision" we are always warned. But WHO has a knowledgeable doctor? What are the arguments one can use with clueless and skeptical docs to get metformin for instance? Could you publish 1 page arguments and studies links per supplement/drug? I looked for 2 years for an MD, double -boarded Plant Based doc and have had a very disappointing time. So we have decided to hire a 2nd doc at a. distance for Telemedicine advice. STILL! many of the plant based docs are closed minded about most avant-garde supplements. Could you Please give us tips on finding docs who are useful ? So far, Dr. Barnard's telemed docs may be the best we can do, and some cost a great deal. 3 Reply 7 replies @kman583 @kman583 1 year ago If you take Athletic Greens in the morning, doesn't that break your fast???? I would think this triggers a small insulin response and starts the digestive process which halts autophagy. Reply @kikiaziz17 @kikiaziz17 1 year ago Are there any free clinical trials that they offer to the public. I really want to try the nmn to see if my menstrual cycle with return. I stopped getting it when I was 31 and I'm 42 now. The doctors had no understanding why and tried estrogen and progesterone to bring it back. I have been in so much pain and fatigue and have serious constipation as well as severe bouts of insomnia and brain fog throughout these 12 years. The doctors just called it a medical mystery and told me to stay on the pill so I can make estrogen. I refused and just tried my best to live a healthy lifestyle. Exercising and intermittent fasting and fruits and vegetables. I try only grass fed protein when I can afford to and I cut out sugar and gluten and dairy. I have tried black seed oil and bee pollen and natural supplements. I just wish I can be under the care of someone who can test me and provide me what I need instead of me trying to figure out what to take. I'm just so drained and tired and honestly have no money to see a functional nutritional doctor. Please if anyone can help me, I would be so grateful. I am so blessed that I had a beautiful son who is my rock before any of this happened. But I would love to be an even better mom and maybe one day, a grandma. I took a course in functional nutritional coaching through mindbodygreen to try and help others but I haven't done any work yet. I'm praying if I get better than I'll be a better coach to others but in my heart I can connect to people who are just tired and frustrated with being told you have to live this way. Reply @timothypawlaczyk8422 @timothypawlaczyk8422 7 months ago No war intended, did you take a COVID19 Vaccine? That being said, thank you for all you do. Cheers Reply @herbertraber7911 @herbertraber7911 1 year ago I read the book in German. There they recommend only metformin, resveratol and nmn. And 1 daily gram each. But the recommendations from the companies are lower than that. I am currently in the USA. There I have only been able to buy resveratol. Walgreens and Cvs do not have the other products, or metformin is only available for diabetics. How do I solve these procurement problems. Which source of supply on the Internet is reliable? How long are the delivery times? Who could help me? Thanks a lot. Sorry about my english Reply @JM-te2jn @JM-te2jn 1 year ago AG1 in the morning with yogurt supplements I'm worried will break fast. Is it that bad to take them all before dinner instead of morning? Maybe just nmn water in the morning is my plan... Reply @brittneytan220 @brittneytan220 1 year ago is trans-resveratrol same as resveratrol? thank you! 5 Reply 3 replies @AH-xs3hg @AH-xs3hg 10 months ago It speaks volumes to me that David Sinclair is 57 and he looks a lot closer to 17. Reply 1 reply @AlexandraHAnderson @AlexandraHAnderson 1 year ago Im so frustrated, I have done research on nmn and nad and am trying to get going with taking it but cannot seem to find any good recommendations on brands from any of the podcasters. A good combo recommended to try that they take. So, stomping on same place for 2 days now. What brand would you recommend and how much. Also with what combination? I am targeting energy, and cognitive improvement. Balance. What could I add to nmn? Reply @SirGolfalot- @SirGolfalot- 1 year ago Good Information. Very interesting science Reply @photograffito @photograffito 8 months ago So do i now take NR since FDA no longer allows NMN to be sold as a dietary supplement? 1 Reply @thando4523 @thando4523 1 year ago Did y’all know that David is actually 83 years old 🙂 Reply @eyeandmind @eyeandmind 1 year ago Hi David and Matt- class is in session. Get here early and sit in the front of class! 3 Reply @kefirkefir8522 @kefirkefir8522 1 year ago Metmorfin lowers level of glucemia .Is that good for a healthy metabolism? Reply @gloriagolemboski4515 @gloriagolemboski4515 3 months ago So if you already take 5000 D3, 200 K2/M7, magnesium, zinc. Multi b,Q10 daily do you stop taking this if you take NMN, metforim, Resveratrol . Still don’t know dosages of these. Please advice. Reply @yourcoachbladimirsantos5136 @yourcoachbladimirsantos5136 1 year ago Does anyone knows where david is getting the supplements from? Reply @madhur369 @madhur369 10 months ago Hi David,Here you said you take Metform at night after dinner.On Andrew's podcast you said you take it in the morning.Please tell correct time ,so it doesn't mess up our circadian rhythm Reply @TheAdayas @TheAdayas 1 year ago David, what are your thoughts on creatine? Reply @nossferatu3288 @nossferatu3288 1 year ago Would someone in their 20ies benefit from these molecules? 6 Reply 1 reply @chrkel8762 @chrkel8762 1 year ago What is your opinion about Celecoxib and Longevity ? Reply @procrastination_at_perfection @procrastination_at_perfection 1 year ago Dr. Sinclair looks lazy and bored (i know he isnt). The fact that i appreciate and enjoy every second of his podcasts shows the quality of his content 1 Reply @mariepascual4654 @mariepascual4654 1 year ago Hello, if I can access metformine, but I have no diabetes what and how do you suggest I take it? I'm 59 years old, 5'2 height and 51 kg in weight, healthy, no maintenance meds. Reply @petercyr3508 @petercyr3508 1 year ago The best longevity molecules are made by your liver if you let it. They are ketones. 1 Reply @jayannonymous1496 @jayannonymous1496 6 months ago What company does David Sinclair use for Spermidine? Thank you Reply @MrSamZet @MrSamZet 1 year ago Taking berberine in yogurt is IMPOSSIBLE. This taste so bitter! Please, do you mean in caps or in powder?? 4 Reply 1 reply @user-uo5rp7ny9t @user-uo5rp7ny9t 1 year ago How much can be absorbed? i.e.I take Resveratrol for 1gram , if i put it into yogurt. thanks! Reply @ArtiumLifshin @ArtiumLifshin 1 year ago If Berberiene is so similar to Metmorphine why not to prefer it? Any potency considerations? David takes Metmorphine and he has the option to take Berbrine as well. So why he prefers it? Reply @unifiedproductsservicesinc9083 @unifiedproductsservicesinc9083 1 year ago If i take RESVERATROL, will it increase my blood sugar level? Reply @Mechaneer @Mechaneer 1 year ago If you don't eat breakfast or lunch, how do you take NMN and resveratrol in the morning? You stated clearly that resveratrol must be taken with food for proper uptake. Reply @VincentPrice138th @VincentPrice138th 1 year ago Please talk about TMG- Trimethylglycine Reply @johnwright4040 @johnwright4040 8 months ago David, when are you going to comment on the recent rumor banning NMN? 3 Reply @janawall3306 @janawall3306 10 months ago (edited) If stressing the body with calorie deficit, heat, cold and exercise extends life, why does stress on the mind activate cortisol and shorten your life? Reply @deepdoubtsboutu6898 @deepdoubtsboutu6898 1 year ago (edited) Ive bought supposedly Resveratrol 1000mg , 500 mg of which is supposed to be Trans Resveratrol from Pureclinica London ... After crushing the White Coated Tablets theres a Dark Beigeish coarse cement powder with distinct notes of vomit flavouring .. Is the slighty Vommity to mediscinal flavour right ... I heard somewhere it should taste like PopCorn ? Reply @bekithomson5200 @bekithomson5200 1 year ago What about pterostilbene instead of resveratrol? Reply @michaelsteinberg @michaelsteinberg 11 months ago I know you can't recommend any specific sites but can you please? haha. I feel I keep reading comments and watching reviews of places that have either diluted or 100% fake pills. Is there a price range I should be aiming for? Do the $500 or $50 pills really make a difference. Ahhhhh. Anyway... Great Podcast. Reply @SirTenenbaum @SirTenenbaum 1 year ago If you're interested in this field, you should read "Ageless" by Andrew Steele! 1 Reply @DarthTerminatti @DarthTerminatti 8 months ago Hi. Are you really trying to ban nmn so that your company can exclusively sell it? 3 Reply @GarnierOlivier @GarnierOlivier 1 year ago A few months ago you mentioned in a podcast that you were taking TMG with NMN, is this still the case as you are not talking about it here? Reply @krzysztof3897 @krzysztof3897 8 months ago one day I will set a pack of speakers on the roof of my house to play this and other podcast this quality translated 9-17 every day to the public around! maybe at least a part could find hearing... positive deviance will one day take over<3 Reply @zaralushlush5903 @zaralushlush5903 8 months ago Prof. Elena Goun, a chemist at the University of Missouri: ,,High levels of NR can increase the risk of aggressive breast cancer and the likelihood of metastases, including to the brain" !!!😮☹😟 2 Reply @ctguitarguy8510 @ctguitarguy8510 11 months ago (edited) Why resveratrol instead of pterostilbene which is the same molecule basically but more bioavailable? Reply @magz0x177 @magz0x177 1 year ago Should you take resvertrol with nmn ? Reply @petereriksson6760 @petereriksson6760 8 months ago I am very confused by the fact that David Sinclair has had a hand in now restricting NMN by the FDA. It seems counter his stand from what I have read and heard from him before. Very sad and disappointing… 3 Reply 1 reply @newleaf8452 @newleaf8452 1 year ago (edited) Would you consider having Kasian Franks, the ceo of Vectorspace AI, on to discuss life bioscience innovation and discoveries through the use of ai/machine learning of data/data sets? I'm butchering their description in less than a sentence Reply @danielriccardi6408 @danielriccardi6408 1 year ago so hard to find reliable sources of these supplements - can you recommend a quality source? Reply @jojobee228 @jojobee228 1 year ago can people on Keto diet take metformin? since the blood sugar level is stable, can metformin cause low blood sugar? Reply @otuzuul77 @otuzuul77 1 year ago (edited) Is there natural alternative for metformin? I heard taking Berberine works equally well if not better.... Berberine v Metformin ? any truth... Reply @cheranvaanavan9245 @cheranvaanavan9245 5 months ago What's the percentage of senescent cell types targeted by fisetin to kill? It won't kill all types of senescent cells right? I want the approximate percentage... Pls do reply... Reply @screamosux @screamosux 1 year ago No mention of TMG? 4 Reply @okoiful @okoiful 1 year ago With taking the resveratrol, David mentioned that it was sentitive to light... how should we take it? I have capsules.. In a dark room? Reply @catherinerossba-fineartma-6619 @catherinerossba-fineartma-6619 1 year ago Trialing your protocols since this January 2022 — especially Re: NMN 2000mg; Risveritrol 1000mg; Berberine ( 1st batch came brown = bad per your recommendations … it’s so hard to know what brands have good content ) — will be seeing my md in March and hope he’s receptive to your protocols too — the 16/8 restricted eating window for eating has caused me to loss 10lbs already ( to be honest I have been off sugar overall plus, been a faster many years ) … and I’m also taking D3 500g, C 1000mg, Quercetin 1000mg, etc 2 Reply 1 reply @cindydeas192 @cindydeas192 1 year ago I'm wondering if David takes everyday supplements like multi-b's, vit.C, vit.D, zinc etc. Since he is fasting and calorie restricting, it would seem that it would be hard to aquire all the important daily vitamins in his diet. He doesn't mention taking any other supplements. Just curious?? 1 Reply 3 replies @ourtube2693 @ourtube2693 1 year ago You should look into how to better monetize youtube videos… you can break down this video into 10 separate and specific videos that you can have ads and sponsors for each video. Also this will improve your analytics and watch times. Your viewers will be happier getting clearer and quicker info and you’ll grow faster and make more money. Everyone wins! 2 Reply @johntl4503 @johntl4503 1 month ago Can we wear out our longevity genes by using too much of these substances? Reply @technofeeling2462 @technofeeling2462 1 year ago (edited) What are trusted brands to buy nmn and resveratrol from? Also I found a site where they say pterostilbene is better than resveratrol and I found information that the best way to take nmn is liposomal nmn. Is this information correct? 5 Reply 1 reply @captainjeffproductions3301 @captainjeffproductions3301 1 year ago Thing I don’t get is he takes yogurt in the morning with his supplements (nmn/resvertrol) which will break the fast. So essentially he’s never getting a long fast, which is talks about the Benfits of. He said it’s better to take the supplements right after waking up. So kind of a catch 22. Reply @aladin3669 @aladin3669 1 year ago (edited) I am asking why the following was not entered into? February 2022, Sinclair raised widespread controversy in the longevity research community by rejecting to communicate in an academic debate in which his resveratrol research was criticized after months of mounting evidence against reseveratrol as a longevity intervention,..... Science after all was exchanging information and viewpoints correct? 2 Reply @singhashon @singhashon 1 year ago Can you take spermidine and nmn +resveratrol ? Reply @birgittal7312 @birgittal7312 1 year ago How can one explain that resveratrol ups the mTor activity in the brain (thereby having antidepressant properties ) and inhibits mTor in other regions of the body (thereby having anti cancer properties) Reply @roscopeco2000 @roscopeco2000 1 year ago Does anyone in UK know a decent source for NMN? How do I know if they any good? Reply @JickFincter @JickFincter 7 months ago David confounded a company that lobbied the FDA to ban NMN. This is so his company can be the only supplier of a proprietary blend. 3 Reply @jsprowse @jsprowse 1 year ago Does anybody know what Dr. Sinclair means by taking resveratrol "with" yogurt? I have capsules, so can I take a spoonful of yogurt and then pound the capsules, or do I need to mix resveratrol into the yogurt and eat it mixed together? Reply 1 reply @SuperKailis @SuperKailis 1 year ago Now when you know such a good info about the supplements what is the rule of thumb to pick the quality ones? I mean there is NMN sold on Aliexpress for third of a price, there are comments of producers using GMO in production of those supplements etc etc How to choose? 1 Reply @paulkiesow7588 @paulkiesow7588 11 months ago I speak to Dr. Sinclair specifically: Regarding results for a non-diabetic who has taken 1 gram/day of metformin for 20 years, I have little doubt you will find my Twitter comments, photos and history to be of great interest professionally and personally. —Best regards, Paul Kiesow (KiesowPaul) Reply @sanjaybhagtani9583 @sanjaybhagtani9583 1 year ago Taking a supplement or injecting young plasma in a very old body would likely lead to rejuvenation in some tissues, but would also lead to rescue of some very damaged cells and since the all tissues and cells are not rejuvenated to the same extent can lead to undesirable outcomes such as cancer. For e.g. suppose a supplement rejuvenates the liver and does not rejuvenate the immune system to the same extent, some liver cells on the brink of senescence would be rescued, but with mutations or damaged DNA and the dysfunctional and aged immune system would not be able to eliminate them Reply @the_q_is5868 @the_q_is5868 1 year ago Found it. Thank you. Reply @obmitty1 @obmitty1 9 months ago You don't sell supplements?? You literally advertised athletic greens, which you got paid for... That's selling supplements. 3 Reply @MightyRoy @MightyRoy 2 months ago Does the ethanol in wine also cause cancer? It gets converted into acetaldehyde which can react with DNA and proteins? Reply @jeffgilligan2004 @jeffgilligan2004 8 months ago That the FDA has banned NMN doesn't matter. Take NR (niagen, nicotinamide riboside), which is the best precursor for NAD in the various cell types. Oral NMN has to drop a phosphate molecule before it can enter a cell. When the phosphate molecule is dropped, it becomes NR. Simply taking NR orally cuts out this inefficient process. Unlike NR, there is no food source for NMN directly. After NR enters a cell, it converts to NMN by picking up a phosphate molecule, and then to NAD. NR is more efficient than NMN, and is available over the counter. Reply @the_real_amir @the_real_amir 1 year ago What is the problem with a spike in one’s glucose level? Reply @partypao @partypao 9 months ago (edited) I have a question that I can't find any information on the internet (or on youtube) or in any video that talks about methformin: first time I tried taking half a capsule of metformin 500mg after dinner. after an hour I felt some pain in my heart for about half an hour, but later it vanished (I do not have any kind of heart condition or any medical condition and Im not diabetic, I'm also lean at about 120 lbs, 5'11 Asian male, in my early 40s) . So I got cautious. I had it rest for about a week, then took another half tablet after dinner, this time there was less pain but kind of a very slight numbing feeling in my heart. After this I did not take metformin as I'm afraid it is doing something to my heart. My question is this: Is there any direct interaction of metformin with the heart, in terms of how it down-regulates energy production? Most information I see on the internet and on youtube says that metformin is actually good for the heart, but now I don't really believe this based on my experience. Reply @dalevandenheuvel3927 @dalevandenheuvel3927 4 days ago In regards to inside tracker can that be used in Canada? Reply @nsiebenmor @nsiebenmor 1 year ago (edited) David is lying about taking Athletic Greens considering he has mentioned in other interviews he doesn't take multi vitamin supplements and also only eats one meal a day, meaning he probably is not going to break his fast in the morning with Athletic Greens. 5 Reply 1 reply @yvettep1093 @yvettep1093 1 year ago Is Dr Sinclair still using TMG with his NMN? Reply @PeterPan711_ @PeterPan711_ 1 year ago (edited) Dear Mr. Sinclair! Am I right? I shoudl not use NR/NMN cause boosting NAD+ with a small molecule activates NAMPT which is an essential regulator of RA-Mediated Inflammation. Overexpression of Nampt promotes osteoclast formation. (I have rheumatoid arthritis :-/) and I also read a study, that RA mices get worse after getting 200 mg of NR. ... I am so sad! Reply @krist6074 @krist6074 1 year ago I’m taking 2 grams of NMN Trans Resveratrol every morning. Reply @esthertorressantillan7489 @esthertorressantillan7489 11 months ago GENERANDO VOLTAJE EN LA SALUD HUMANA Reply @silkhead44 @silkhead44 1 year ago I take resveratrol and fast 16:8 for over three years now...partner says don't stop Reply @jorgedore5499 @jorgedore5499 9 months ago This guy Sinclair , Big CON men 3 Reply @christoferlavesson4453 @christoferlavesson4453 1 year ago There has to be a blooper in this episode when it comes to Spermidine… 1g he says but the commercial options (ie SpermidineLife etc) are going for 1 mg daily dose. David is on the board of advisors for one of those companies selling the 1 mg a day Spermidine product so why would he take a dose of 1g when they recommend 1 mg and the EU says 6 mg daily is the upper recommended safe limit for Spermidine supplementation? Makes no sense whatsoever. Ok so Resveratrol seems to have somewhat of a consensus on that 300 mg/daily is a safe dosage, and David takes 1 g he says. There is a difference, but for Spermidine 1 mg vs 1 g is just a crazy difference. Apparently Spermidine is also widely available in almost all diets. In northern Europe they did a study that found that between 10-25 mg Spermidine daily is easily achieved with just ”normal” diet for an adult. So that leaves the question what difference would 1 mg extra do if you get 15-25 mg through normal food? OR what is David thinking if he really takes 1 gram of Spermidine? That would be completely uncharted waters in terms of daily amounts… Reply @sanjaybhagtani9583 @sanjaybhagtani9583 1 year ago I would say that steve horvath was wrong in claiming that the aging clock starts from birth , because at birth what is being measured is the growth clock. The aging clock starts at the end of puberty when aging commences. What is actually happening is that a growth gene network is modified at puberty in to an aging gene network. Since almost all the genes which were part of the growth gene network are now functioning in this new aging network and this leads to antagonistic pleiotrpy Reply @rustybolts8953 @rustybolts8953 4 months ago Spermidine from wheat germ. That make me feel better about it too. Now I can actually take the stuff. Reply @janlock9579 @janlock9579 1 year ago I was just wondering... when the cheap test is coming. Last year you said : at the end of this year. I'm on the wait list but impatient. Have been using a great deal of money for several years and it's all on faith. Reply @tiffanygonzales9455 @tiffanygonzales9455 1 year ago Which brand of supplements should we take? Reply @foogentog @foogentog 8 months ago Sucks that you chose becoming filthy rich over actually helping people. Lobbying the fda to ban nmn. Pretty damn screwed up. I wonder how people like this sleep at night. 4 Reply @omerozvardar8545 @omerozvardar8545 1 year ago Which field of medicine is relevant to this subject? I want to talk to a physician but I am not sure who would be knowledgeable about all this. Would it internal medicine? Reply @yourcoachbladimirsantos5136 @yourcoachbladimirsantos5136 1 year ago Sounds great but where should we buy all those legit good quality supplements David or Laplante? Reply @annparas100 @annparas100 1 year ago Please any advice on ibm I’m having falls so it’s getting scary I’ve started eating now btw 1 to 7 it’s basically an auto immune disease 🙏 Reply @rtothe7068 @rtothe7068 1 year ago You talk about Metformin but doesn’t the dipeptide Carnosine perform the same functions in your body without the side effects? Reply @sunnos999 @sunnos999 1 year ago Hi! How can I be sure that the product really is what it declares it is when I buy? So many that sells and to wo different prices. How can I get best price possible and be sure that it really is resveratrol, NMN and what the label says it should be? How can I know that I can trust the company that I buy from or the producer? (if it is not a drug, but just a supplement like resveratrol) Please. Really want to be sure that I get the "real thing" when i buy so I get the results I want. Would be really thankful if you could help me. Best regards! Magnus Reply @RogersBenjamin @RogersBenjamin 7 months ago David, If you are truly concerned with people trying to live healthy and longer - then why are you working to monopolize the very supplements that you encourage people to take? That has ZERO to do with "caring for people's health" and EVERYTHING to do with "line your pockets seeking to gain even more wealth than you already have". I'm highly disappointed in your efforts (and, yes, you'll claim "not my efforts, just the efforts of the company that I co-founded and am financially tied to." Enough malfeasance, money-grubbing, false practices and corruption. Cease and desist your efforts to monopolize NMN supplementation. This is downright *EVIL*. 4 Reply @pespsijackson3958 @pespsijackson3958 1 year ago curcumin resveratol quercetin fistein does the same as fasting because it inhibits mtor fasting also inhibits fasting Reply @sanjaybhagtani9583 @sanjaybhagtani9583 1 year ago Aging Hypothesis A gene network which was in control during the growth phase is modified at puberty by activation of some unidentified genes. Due to this, the whole network modifies itself to implement the aging program, therefore various genes which were beneficial in the previous avatar of the network turn deleterious in the new network, leading to the so called phenomenon 'antagonistic pleiotropy'. Any supplement would only perturb a small part of this aging gene network, with almost no life extension taking place. Also any supplement would also be antagonistic to this aging network, which could lead to negative feedback. The only solution is identifying this network and inhibiting the components which are activated during puberty, so that the earlier growth gene network gets activated. Partial reprogramming does this by using non optimal factors to inhibit the aging network Reply @nicksmith-chandler458 @nicksmith-chandler458 1 year ago I just took 20 grams of NMN and I’m as hard as a rock. “ Nurse help” 📣 Reply @howardrusso8081 @howardrusso8081 6 months ago I have believed in all he has to say until this podcast. Now I see he is a pharmaceutical salesman as opposed to a medical doctor that does research. Reply @andrewr76861 @andrewr76861 1 year ago Thoughts on intranasal NAD+? Reply @dominikh9526 @dominikh9526 1 year ago I just hope Sinclair is not finishing his transformation into a salesman grifting on the mortal fears of his audience. Resveratrol has been shown to not have the dramatic effect in humans, same with metformin. Metformin is by consensus of research not adviced for anyone younger than 50 and has a bad rate of return. Fasting is by no means magical compared to general calorie restriction, as shown time and time again in monkey studies (actual hallmark of translational research) and tightly controlled human randomized control trials. NR and NMN are interesting supplements for sure, same goes with the new research for AKG. But other than general lifestyle interventions that have been preached forever (eat mostly greens, take your calories carefully, limit saturated fat and processed (animal) products) there is really nothing new or proven here beside mechanistic guesses of limiting BCAAs (where I'd have to point out that while probably valid, the risk of little muscle mass is still a risk and limiting BCAAs or even total protein does not halt mTOR activation by muscle hypertrophy stimulus by itself). Athletic greens is piss poor formulated with very questionable quality standards. Background pollution levels of heavy metals are a risk. Any quality "safe and sound if once a day" multi compound would cost even more. Just as an example. I am an PhD student in biochemistry and bioanalytics myself, I get it. New research is exciting. But let's not blow every bit of new yeast or rodent research out of proportion. 15 Reply 8 replies @SzaszaG1 @SzaszaG1 1 year ago So if the mice take 400 mg/kg MNM in the studies then 1000 mg for a 70 kg adult seems like REALLY low dose. Reply @loreprokop1319 @loreprokop1319 11 months ago I would like to begin this journey, but, like you, dont want to do it in the blind and need repeated measurements to monitor progress. One measurement is several hundred $, can you point me to any economical way of getting epi-age, mitochondria, etc, on some regular basis, like 3-6 months? You mentioned a possible "group" or pool??? Much appreciate the casts and sharing this knowledge and science. Reply @irenedearman @irenedearman 7 months ago (edited) Where and how can I get NMN? I mean the one you use , I have been used other company NMN , will .like to try the one you Recommend , also help my mom, thank you .🙏🙏🙏 Reply @KradolfusdePedoclown @KradolfusdePedoclown 1 year ago I love how these two vampires use science and supplements as a cover up for why they still look so young;) 1 Reply @smokecurl9437 @smokecurl9437 9 months ago According to recent research studies, metformin could reduce the male hormone, testosterone. So definitely not an exciting option. 1 Reply @venusrea2011 @venusrea2011 8 months ago All about the money for you David? I will no longer follow you. Instead of helping humanity your now just as bad as big pharma. 3 Reply @NoWay1969 @NoWay1969 6 months ago Hundreds of glasses of red wine a day might not make you live longer, but it would certainly make the dying more palatable. Reply @Livingwithadog @Livingwithadog 1 year ago Is there a difference between grape and Japanese knotweed resveratrol? Reply @shulehr @shulehr 1 year ago useful stuff Reply @jameswhite170 @jameswhite170 1 year ago Dr. Sinclair. Are the methods in your podcast the only you do to 'appear" so young. or do you have external skincare/procedures to look so good? Reply @olegriabov301 @olegriabov301 1 year ago At what age should I take these supplements? I'm 26 1 Reply @salardz @salardz 1 year ago I wish your co-author was a scientist. at least he could have asked smart questions rather than interrupting you constantly! 3 Reply @bronsonstone725 @bronsonstone725 6 months ago "You're one of the few people who eats my vegemite", that's something I don't hear often Reply @suewade3970 @suewade3970 9 months ago His voice for his sponsors soooo smoothing Ok David ill buy everyone of your sponsors products cause you said so Reply @fran-iv1xp @fran-iv1xp 1 year ago metformin requires prescription in my country. is there an equivalent? Reply @jac1011 @jac1011 1 year ago crazy to think that they are both in their 90s 😲😲 Reply @ScottSummerill @ScottSummerill 1 year ago (edited) No study is using daily Fisetin. In fact, there’s concern that we actually need some senescent cells. Check the Mayo Clinic’s regiment. Also, there’s a new Metformin study that found no benefit to anyone who’s not actually a diabetic. Check a recent Brad Stanfield video. Reply @karthi451 @karthi451 1 year ago 1st comment 3 Reply @roverdover4449 @roverdover4449 1 year ago Dr. Sinclair says he sprinkles his resveratrol on yogurt in the morning. So should I open up my little capsule, and actually sprinkle it on the oily food? Or just take the resveratrol capsule along with a meal with oily food? Maybe he buys the stuff in powder form by the jar full, but my question still stands. Should I open up my resveratrol capsule and actually sprinkle it on my food? Reply 1 reply @AC-vz9cz @AC-vz9cz 1 year ago Thanks David ! Cheers West coast BC Canada Reply @stefaniehartman592 @stefaniehartman592 1 year ago Fascinating stuff 👌 1 Reply @danieldipietra2307 @danieldipietra2307 1 year ago As a meat based protein diet is not good, I would love to know if a high protein plant based diet is ok? Reply @louis9939 @louis9939 3 weeks ago Is vitamin B3 a potent NAD+ booster ? Reply @khalid1130 @khalid1130 1 year ago If you are not MDs why then you are saying what you are saying? It is like you want people to expriment on themselves and not getting any legal issues. What a strange way David. 6 Reply 2 replies @rustybolts8953 @rustybolts8953 4 months ago So with thousands of substances to be tested: At one decade per experiment, that's about 100 thousand years/thousand experiments. If I had 100k years to wait, I would gladly bay the beer. Is there no way to speed things up? Reply @fatimafreire2841 @fatimafreire2841 1 year ago 😊👏👏👏👏❤️ Reply @stephenodey5147 @stephenodey5147 1 year ago Excellent Thank You Reply @qe9933 @qe9933 1 year ago On a keto diet where blood glucose is already low, is taking metformin safe? Reply @Socialhack @Socialhack 1 year ago Have you done any work with Crispr with regard to anti aging and what is your opinion on it? Reply @dalevandenheuvel3927 @dalevandenheuvel3927 2 days ago (edited) The levels app is only good for people in the United States and the United Kingdom, do you have another one for Canadian's or other people from other countries to use? Reply @Andrea-64 @Andrea-64 1 year ago What can people with very little money take? Thank you. Reply @lucagonnet4784 @lucagonnet4784 1 year ago With one meal a day how is it possible to mantain at the good levels electrolytes ( potassium magnesium sodium)? Reply @jayb8056 @jayb8056 1 year ago Levels is not available in my country. Would it be worth getting a blood glucose monitor marketed for people with diabetes and just plot my own data? 1 Reply @roscoe543 @roscoe543 11 months ago “Ideally you buy 100% niacinamide powder and use 1 (or 1/2 of) 1/64th of a teaspoon three times a day (25-50 mg) in water. Here’s another vendor of the 4 oz. and 1 pound of the same product. Does this work? Is to much of this counterproductive. Thanks like your videos. God Bless Reply @marie-elsarochebragg5700 @marie-elsarochebragg5700 1 year ago Question: Why don't we take NAD straight and AMPK straight as supplements? Reply 1 reply @stephencarlsbad @stephencarlsbad 8 months ago Sinclair hasnt made a video in 9 months. I wonder why he abandoned doing podcasts? 1 Reply @kman583 @kman583 1 year ago Does Arginine alpha-ketoglutarate (AAKG) age you or break a fast???? AAKG is a dietary supplement used by athletes and bodybuilders to improve sports performance, reduce muscle fatigue, and enhance recovery. It enhances nitric oxide and dilates blood vessels for increased oxogen transport. Reply @PA-eo7fs @PA-eo7fs 1 year ago What age would you start NMN and Res? 2 Reply @thoralder4963 @thoralder4963 6 months ago Talk to my physician, my physician and most physicians are clueless. When it comes to supplements, unfortunately, very often it’s a recommendation for a prescription. Reply @kanchankumar1519 @kanchankumar1519 1 year ago Clarification for spermidine dosage required. David says he takes 1 g per day. 1g pure spermidine, or 1 g of wheat germ extract?? Can someone please clarify. The commercially available options I think provide 1 g of wheat germ extract and they do not mention the amount of spermidine actually present in them. @David Sinclair Reply @shylaandrews4435 @shylaandrews4435 1 year ago (edited) Hi please let me know how a diabetic can take advantage of fasting ?? As hypoglycaemia will set in during fasting period Reply @doctor_ohad @doctor_ohad 1 year ago sheesh - nearly 50k views in 1 day. lots of longevity freaks out there! :) Reply 1 reply @lighthealerastrid1465 @lighthealerastrid1465 1 year ago I took berberine for a while and then had to stop due to horrible stomach pain. Disappointing for sure. Reply @Corrans @Corrans 1 year ago David, in this podcast you say you take Metformin at night. On Andrew Hubermans podcast, you said you take it in the morning and skip it on days you exercise. But in this podcast you say you exercise every day. I am confused. Have you changed what you do? And how you do things? Reply @erikakitagawa834 @erikakitagawa834 1 year ago Snap I’ve been taking my resveratrol with water on an empty stomach (΄◉◞౪◟◉｀) thx for the yogurt tip 👀 Reply @lordoft2410 @lordoft2410 1 year ago What age can one start some of these protocols? Reply @ivetteanziani4083 @ivetteanziani4083 1 year ago Can anyone tell me what’s a good quality NMN supplement brand? Reply @akgh2010 @akgh2010 1 year ago Anyone can suggest a good phosphate supplement to complete Tru Niagen NR+. Reply @davidfritch6954 @davidfritch6954 1 year ago Anyone know if I got good nmn? It’s from gene formulas, good manufacturing practice, says it’s beta-nicotinamide mononucleotide. Reply @Federico-pn9hp @Federico-pn9hp 1 year ago can Resveratrol, NMN or NR help with vitligo ? Reply 1 reply @yaaaaassss-ws8eh @yaaaaassss-ws8eh 4 months ago Has anyone posted comment with each specific dose recommended for each supplement or drug? Reply @katharineofarrogant7805 @katharineofarrogant7805 1 year ago I think David is looking younger every week. In a couple of months he may be back in diapers! 1 Reply @manunav7336 @manunav7336 1 year ago Dr Sinclair is taking pterostilbene better than taking resveratrol ? Reply @geoffhom @geoffhom 1 year ago Matthew LaPlante asks great questions, but he keeps mispronouncing both "senescent" and "senescence." It happened on a previous episode, too. Reply @jerrycaddie838 @jerrycaddie838 1 year ago (edited) So is resveratrol an NAD booster???? Seems if your just taking Resveratrol your good to go. Is that correct? Reply @louisewendin5634 @louisewendin5634 1 year ago Where can I find the show notes? thanks Reply @Myfilipinaqueenandpersianlion @Myfilipinaqueenandpersianlion 1 year ago (edited) At what age should we ttake these supplements? Is this only for older people or younger people can take it too? 1 Reply 1 reply @Sky10811 @Sky10811 11 months ago Does IR light helps to keep skin young? Reply @hughwhite1429 @hughwhite1429 1 year ago Can you give us some insight into cannabis and the following please:We've found that cannabinol protects neurons from oxidative stress and cell death, two of the major contributors to Alzheimer's," says senior author Pamela Maher, a research professor and head of Salk's Cellular Neurobiology Laboratory. "This discovery could one day lead to the development of new therapeutics for treating this disease and other neurodegenerative disorders, like Parkinson's disease." Reply @arleneevans6342 @arleneevans6342 1 year ago You don't need monitors. Here is a novel idea - how do you feel.. Change your diet one item at a time. Same if you want to take supplements. Take one for thirty days and assess whether to continue by how you feel. That's my opinion anyway Reply @BEATRIXKIDDO14 @BEATRIXKIDDO14 1 year ago Matthew has a fun personality 🙃 1 Reply 1 reply @jonparrott4081 @jonparrott4081 2 months ago If complex carbs raise your blood sugar less but for much longer than things that rasie it in a short spike, doesn't it equal the same amount of insulin being stimulated? Who says stable levels are better? I find i gain much more weight with complex carbs because my body has all day alone with the food and absorbs it all! I've lost weight through IF but eating many simple carbs in addition to healthy foods .... I think it is more important to gradually increase your fasting strength and processes by cycling your fasting times gradually longer and longer like exercise, because fasting IS exercise at the cellular level .... Reply @olafstorbeck4777 @olafstorbeck4777 1 year ago It's so funny to see how crapy the YT advertising algorithm is: halfway through the interview they bring an ad for a sweet chocolate breakfast cream, a devilish, addictive, blood glucose rising industry "food". Who of the "live-longer-healthier" community who spend half an hour listening to David Sinclair would even look to this stuff? If the AI algorithms that bad than there is still hope for mankind... 😉 Great interview by the way! Reply @sparechange25 @sparechange25 1 year ago Let's talk about trauma and the ability to use one's mind to cause an aneurysm in another. Let's discuss the psionic shockwave the pandemic caused. Let's talk about experimenting on humans with biotech, beginning with ww1. Add radiation and time to gmo human trials on behalf of the United States. Let's talk about old college buddies. Let's talk about Faucci. Let's talk about the future of stem cell therapy/gene therapy, in biotechnology... in defense contractors. Let's talk about bayer and Monsanto. Let's talk about the "spanish" flu. Let's talk epigenetics, behaviorism and the generational differences. Let's talk about trauma, MCAS and TDI. Let's talk neuroscience. Let's talk quantum theory and the gravity of zero. I love that you college kids think listing your school, lends you credit. You're all a decade behind... I know this because you're a top 25 stem cell college kid. It doesn't require a degree to be a Kennedy during prohibition... and it doesn't require your college to apply gene therapy. You guys crack me up. Feel free to reach out. I could use your vocabulary. 🤣 Reply @alescervinka7501 @alescervinka7501 1 year ago Should I take Berberine at night like metmorfin? 1 Reply @lipstick318 @lipstick318 1 year ago (edited) OK, That takes Me to Age 98 or 86, then I Still Die... What if, We Splice In Some Telomeres At Age 70, using the RNA/mRNA process and Telomeres Take hold at the End of the Chromosomes???? Wouldn't that Double Our life Span to Beyond 140 or 160 Years Old???? Nobody Said, it Would Be Easy, But It's Do-a-able... Oh, if this Works... Give Me Some Credit, Please... 3rd Request... I Guess, I will just have to Do It Myself... 12.01.2021 1 Reply @qijingfan5656 @qijingfan5656 1 year ago please just also tell us where to buy them? which brand is trustworthy? 1 Reply @alejandraalvarezdetoledo1783 @alejandraalvarezdetoledo1783 1 year ago (edited) Question, i guess you wouldn´t want to get into the brands issue, but internet offers so many brands that can you give the ones at least you know are trustworthy? i am sometimes absolutey lost on which to choose- 1 Reply 1 reply @suzannevan @suzannevan 1 year ago 00:09:21 You mention that you're actively keeping yourself away from the supplement industry so you can talk about supplements without bias. Is your role with Metrobiotech working on MIB-626 and other NAD+ precursors somehow limited to avoid this bias, since you're a co-founder, advisor, board member of parent company EdenRoc, inventor, and investor with equity (involved since 2015)? I appreciate the podcast and all of the very helpful information being provided, and it makes sense that you would be affiliated with a company working on this, given your research! I'm just confused about the statement that you're staying away from the supplement industry. Reply @jenmckeon8512 @jenmckeon8512 1 year ago I think it’s crazy that people charge $3000+ for NAD IV s😩😩 Reply @Dani-jo9yr @Dani-jo9yr 1 year ago (edited) Really? This is the episode everyone was waiting for?🧐Well, maybe for ‘pill popping’ bunch, ones who don’t want to do it hard but healthier way- lifestyle changes!!! I guess this is all good infos but I definitely would not promote this kind of way as ‘easy ‘ way out.. bet big pharma would love this 🤨😖🙄Anyway, looking forward to more different kind of topics in next episodes 👈 1 Reply @anonymousperson9784 @anonymousperson9784 4 months ago The best hangover cure is to not drink alcohol Reply @cholakicha @cholakicha 1 year ago 38:20 Oh, that was hilarious! Reply @h20no63 @h20no63 1 year ago Ok so at the end he says what he takes everyday. The questions is at the beginning of the show you say you take athletic greens which is a supplement but do not state that you take them at the end of the show ? Reply @Joyces-Favorite-Art-Tutorials @Joyces-Favorite-Art-Tutorials 7 days ago Please somebody tell me which trusted brand of NMN with Resveratrol to buy? Reply @christopherwykel866 @christopherwykel866 1 year ago I told an Asian friend of mine about this podcast, she asked to try taking NMN before a night of drinking. I gave her 1g of NMN 30 mins before dinner where she intended to drink alcohol. Typically, she will buy one cocktail and her face will glow (become reddish) about half way through it. (While eating) when she drank after the NMN supplementation she was able to consume the entire drink and did not get the reddish glow. Now she wants to buy some of her own NMN to really put this to the test. 1 Reply @danielmccarthy7998 @danielmccarthy7998 6 months ago Has any of this research been verified by others? Reply @chrishoose9711 @chrishoose9711 1 year ago Dr. Sinclair, I’m baffled how the entire focus of this podcast is anti-aging yet there’s no mention of the negative effects of alcohol and aging/lifespan. Not only that, you actually seem to encourage drinking red wine, despite saying in the same sentence that the levels of resveratrol needed would be impossible to get from red wine. Don’t the negative effects of the alcohol outweigh any minimal health benefit? I thought that’s been fairly well established at this point in the science literature. Reply @miiitchhh225 @miiitchhh225 1 year ago Dr. Sinclair you’re awesome and you are so natural when talking about the science, but when you read the sponsor script it looks so strange and out-of-character. Just ad-lib it man! Reply @jeremiez381 @jeremiez381 1 year ago Any vitamins you supplement? K2, D3? Reply @JelenaVM @JelenaVM 1 year ago Is the way for women to raise testosterone levels the same as for men? Reply 1 reply @PCSalesStaff @PCSalesStaff 1 year ago Can anyone recommend a resveratrol supplement? Reply @kameronsteelefitness3281 @kameronsteelefitness3281 11 months ago It doesn’t appear that the hosts comment here so a recent Spermidine study should be addressed: An April 2022 China study found that higher levels of Spermidine coincided with more strokes. “New stroke cases had higher baseline levels of spermidine than controls…. After multivariable adjustment, individuals with spermidine ≥ 205.9 nmol/L (T3) higher risks of stroke (HR 5.02, 95% CI 1.58–16.02) with the lowest quartile (< 136.9 nmol/L) as reference. The association between serum spermidine levels and risk of stroke seemed to be consistent and was reproducible in our cross-sectional studies.” Reply @adolfonotholtcalles7856 @adolfonotholtcalles7856 3 months ago (edited) Could you recommend me a reliable brand of NMN and resveratrol? I wouldn’t want to invest on a brand that doesn’t work. Reply 1 reply @yp9148 @yp9148 1 year ago In 7 months I will get an A* in Biology . TRUST ME. Reply @juanmarsa @juanmarsa 3 months ago Come on man! If you're eating yogurt in the morning with your supplements, that's breakfast. You're eating twice a day, and you're skipping lunch. To make one meal a day, you should take the yogurt with the supplements before or after your dinner. Do you not have enough with the caffeine during the day to satiate you? Thank you Reply @alicebush108 @alicebush108 1 year ago What about testosterone replacement? Any evidence that it extends or shortens lifespan? Reply @daniellescott6701 @daniellescott6701 1 year ago What's the dose of metformin? Isn't it kind high for it to be effective? How much??? Reply 2 replies @s3731711 @s3731711 1 year ago I am not pre-diabetic but began metformin for weight loss as I struggle with sugar addiction and obsessive thoughts about eating. The metformin has 100% helped me overcome my sugar addiction. I believe the mechanism is it has sensitized my cells to insulin better so my cells are using food for energy more effectively and it has balanced my blood sugars so I am not getting major highs and lows. This has removed that anxiety feeling I used to get when I was craving something sweet. I also started with a 36 hour fast and am trying to keep my eating window within 4 hours, not eating any processed sugars and limiting processed carbs. I've been dieting my whole life and this is the only thing that has seemed to get me over that initial craving hump so I can create new healthy habits to live by. Reply @sarahowick5456 @sarahowick5456 1 year ago So where to start for information on how much to take, which brands are reputable, etc? Are there any websites or groups, or is this information in his book? Reply @ineskhaz1203 @ineskhaz1203 1 year ago With the Reverse aging process… would it be possible for the older woman to get pregnant again ?? Like reverse menopause ?? 1 Reply @ryandoherty9696 @ryandoherty9696 1 year ago What good is any of this data when it's coming from studying generations and generations of lab-mice? Which are adapted differently than anything resembling a person, or wild and free animal? Reply @mrfaceless2697 @mrfaceless2697 1 year ago David Sinclair needs to remember hes talking to the host but the listeners are the viewers and he needs to slow down on some things he talks about Reply @mmantsaediale204 @mmantsaediale204 9 months ago Hi David; where can I buy NMN - 1 Reply @petercoderch589 @petercoderch589 1 year ago Sinclair committed a major faux pas in this podcast, saying that NMN is more effective than NR. How is NMN more effective if: 1. It gets broken down in the gut and absorbed as NR? Because the phosphate group is removed with 100% certainty in the gut. 2. Even if it did make it into the bloodstream intact, NMN contains a charged phosphate, and molecules with charged phosphates cannot enter cells. Anyone with as little as 2 years of college level organic chemistry can understand the concept that the phosphate moiety of a molecule is dissociated in the presence of acidic solutions, like the hydrochloric acid of the human stomach. The fact that NMN is closer to NAD+ than NR doesn't matter because NMN cannot survive digestion or enter cells. Reply 1 reply @bekithomson5200 @bekithomson5200 1 year ago The WSJ reported on Jan. 11 that the TAME study is still delayed by Covid. Reply @starfox300 @starfox300 1 year ago I wonder what David thinks about AKG Reply 1 reply @lynnie9715 @lynnie9715 1 year ago I dunno why, but your commercial acting cracks me up so much. Reply @calmingrelaxingmusic6164 @calmingrelaxingmusic6164 8 months ago I am having body aches using metformin. Do I need to take it with food? Reply @elbowroom3663 @elbowroom3663 1 year ago there is no French paradox. The French mortality assignments are recognized not to be accurate. Reply 1 reply @mirusvet @mirusvet 1 year ago Thank you! Reply @DarekBirton @DarekBirton 8 months ago I don't believe him but I am willing to be objective. He appears to be lying but. He is an authority in his field of study but I prefer Dr. Longo and Dr. Alan Goldhammer. Their studies seem more believable and they don't hype anything without backing it up with real clinical studies etc. 2 Reply @kenyenmusic7548 @kenyenmusic7548 1 year ago Aaahhhhh i love this shiiiit!!! Reply @Norgy1989 @Norgy1989 1 year ago What about Pterostilbene? Reply @semaaral2498 @semaaral2498 1 year ago Vinegar if it's ok can if we mix it with resveratrol instead of olive oil. Pls someone who Listened this podcast write to me. Pls. I know olive oil is high in calorie but Vinegar is acidic how does it reacts with resveratrol. . Thanks. Reply @nature-zp7pc @nature-zp7pc 7 months ago does eating less often stimulate producing insulin? Reply @IshaBhalla @IshaBhalla 7 months ago I'm confused whether to take NMN or not Reply @rogerelder1196 @rogerelder1196 1 year ago It sounds like resveratrol could be given in liposomal form. Reply @panteraman15 @panteraman15 1 year ago What resveratrol and nmn brands and what quantity do you people take? Reply @heidipollard8097 @heidipollard8097 1 year ago Which (metabolic mechanism) does FASTING aid in longevity? What research has been done on fasting vs metformin? 1 Reply 1 reply @didahuka7986 @didahuka7986 3 months ago What is actual age of Dr David Sinclair? If I am not mistaken his biological age is 34. Reply @iradesign4796 @iradesign4796 1 year ago I have an rare symptom. My glukose level are low and after eating are way more low. What it mean? Can someone find out why... Reply @brunorigo @brunorigo 11 months ago I would like to know if we can maintain (a little extra) muscle, AND be inm Medical Interventions (TRT, HGH, Stem Cells, etc.) For Longevity | Lifespan w Dr. David Sinclair #5 David Sinclair 299K subscribers Subscribe 8.3K Share Download Clip Save 264,220 views Feb 2, 2022 Podcast Episodes In this week’s episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante cover potential anti-aging interventions that are on the cutting edge. They share the latest research surrounding testosterone replacement therapy (TRT), human growth hormone (HGH), peptide supplementation, exosomes, stem cells, and cellular reprogramming. The idea of human rejuvenation and potential paths towards resetting the aging clock is also discussed. #DavidSinclair #Longevity #Lifespan Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Levels - https://levels.link/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Lifespan podcast website: https://www.lifespanpodcast.com Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsincla... Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclai... Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante Stay up to date with David's work to democratize biological age testing and insights: https://www.tallyhealth.com Timestamps: 00:00:00 Kicking Off Episode Five: Interventions on the Cutting Edge 00:02:39 Expressing Gratitude to the Sponsors 00:05:28 Testosterone Replacement Therapy 00:10:09 Human Growth Hormone 00:13:56 Peptide Supplementation and Regenerative Signaling 00:18:11 MOTS-c, Humanin, and Other Peptides 00:25:05 Exosome Therapy 00:31:56 A Primer on Stem Cells and Yamanaka Factors 00:37:59 Stem Cell Aging and Cord Blood Banking 00:41:42 The Therapeutic Potential of Stem Cells 00:43:37 Cellular Reprogramming 00:51:35 Resetting the Aging Clock 00:56:50 The Future Looks Bright 00:58:15 Next Week’s Episode: External Aging 00:58:36 Subscription and Support Options Links: Benefits and risks of testosterone treatment: https://bit.ly/35I3uTs Eunuchs are long-lived: https://bit.ly/3ukL1GU Longevity is enhanced in mice lacking growth hormone: https://go.nature.com/3AOTW4k MOTS-c and age-dependent physical decline in mice: https://go.nature.com/34aUgi6 Fatty liver disease, obesity, and an analog of MOTS-C: https://bit.ly/3Ho7GFE Humanin regulates lifespan and healthspan in mice: https://bit.ly/3Gy0lm1 Humanin ameliorates diabetes in mice: https://bit.ly/3ukiFw7 Mouse aging can be modulated via exosomes: https://go.nature.com/3oi0sM4 Exosomes and ulcer healing in older mice: https://bit.ly/3oEhPaf Generating induced pluripotent stem cells: https://bit.ly/3APMypv Vision loss after ocular injections: https://bit.ly/3L2yVIh Mesenchymal stem cells and human frailty: https://bit.ly/3s6kzxX Restoring vision loss in older mice: https://go.nature.com/335iysI Reversing epigenetic age in humans: https://bit.ly/342XXGJ Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. Chapters View all Explore the podcast 8 episodes Podcast Episodes David Sinclair Podcasts David Sinclair 299K subscribers Videos About 572 Comments rongmaw lin Add a comment... @daviessusan1000 @daviessusan1000 1 year ago A discussion on menopause and HRT/TRT would be brilliant! 165 Reply 21 replies @dulalrajbaruah2576 @dulalrajbaruah2576 1 year ago I am a G I surgeon but I take particular interest in chronic diseases and old age . It would be super interesting to see if we could really wipe out old age related chronic debilitating diseases in future. 63 Reply 7 replies @pubz2149 @pubz2149 1 year ago I have been following Dr. Sinclair since I was 25. I am 22 now. 85 Reply 5 replies @tigerwoodsiv @tigerwoodsiv 1 year ago All of this is fascinating to me as someone in my early 30s. I’m really hoping this keeps going in the right direction and quickly. 21 Reply @cypriankariuki175 @cypriankariuki175 1 year ago Am a young clinician in kenya.....this podcast always make me feel like am attending longevity lectures in campus. THANK YOU AND GOD BLESS YOU. 159 Reply 8 replies @michaeltegler157 @michaeltegler157 1 year ago David and team, Thank you for the continued commitment to optimizing life. A discussion on the Microbiome would be tremendous as I have struggled with GI issues (IBS-C) and believe I have been suffering with invasive candidiasis as I have recently taken fluconasole which provided relief not only in my stomach but also caused the pain and stiffness to go away from joints, back, shoulder, etc. I am 49 yrs old and have taken many antibiotics throughout my life predominantly for sinus related issues which may have caused this condition of excessive candidiasis in my body and am curious to know if there is a way to restore the microbiome and healthy bacteria to optimal levels without Fecal Matter Transplantation as this is not readily available in the US. I'd also be inclined to go away to a clinic of sorts for 30 days if you know of one that would provide the structure and support to restore the microbiome. Thanks again for all of your dedication and work! 4 Reply @hopecarlson1231 @hopecarlson1231 1 year ago (edited) I'm loving this channel! It's my favorite kind of content to nerd out to.🤓 I've been binge watching, like Netflix. We humans and our genetic and cellular makeup are so incredibly fascinating. Thanks 🧬🧫👩‍🔬 10 Reply @Artilectual @Artilectual 1 year ago Thank you for your time and content. As a blue collar know buddy, your work has kept me younger and fitter than I ever really expected possible. I've been following your work for years. So happy to have all this content in one place, cataloged, with such depth. ❤️ 🙏 truly grateful 5 Reply @ethancowart6765 @ethancowart6765 1 year ago honestly feels good to be hearing someone like david say that peptides are promising and can be helpful if deployed properly and used properly. they have helped tremendously with a tbi that i got from a car accident. ive known this myself for a while but now it seems to be getting more known and looked at for the future. 1 Reply @robertmariano @robertmariano 1 year ago This podcast on anti-aging along with the research on CRSPR and gene editing/disrupting really is amazing. The only thing better than this would be a way to transplant consciousness into an already younger version of oneself. I watch this on YouTube then I listen to it again on the podcast Reply @Samantha-qf5ee @Samantha-qf5ee 1 year ago (edited) Looking forward to the entire episode that covers women's hormones (because we don't already live long enough?) Thank you! 48 Reply 5 replies @Alex24998r @Alex24998r 1 year ago (edited) Again Dr. Sinclair, your colleague is asking Excellent and Thorough questions , that cover all points a viewer such as me was thinking about- such as the growth hormone discrepancy, among many other questions. Thanks to both of you for putting forth such interesting and fascinating information. 19 Reply @TimeRiderTime @TimeRiderTime 1 year ago Thank you for widening the boarder of understanding ageing 🙏 Thank you for your personality and work you put in yourself. Deepest respect🙏 3 Reply @gro16 @gro16 1 year ago Man, Mathew is truly superb in slowing it down and also not loosing any threads. Thank you Sir! 4 Reply @bestrongandloveyourself2370 @bestrongandloveyourself2370 1 year ago Another very interesting episode! I love this podcast! Can’t wait to know more about aging outside! ❤️❤️❤️ 2 Reply @Midori_Hoshi @Midori_Hoshi 1 year ago These podcasts are absolutely amazing and life changing! Thank you so much. Reply @rustybolts8953 @rustybolts8953 4 months ago Only over the past 5 to 10 years have I finally learned the importance of good rest and sleep to good health. This is an ongoing learning experience. Will report again in 3 years if I am still about. Reply @Aldraz @Aldraz 1 year ago (edited) This was a very interesting episode! I like this topic as it has not been repeated before in other interviews. I hope one day we can just take a pill that's gonna make us younger haha. 5 Reply @callofthedark @callofthedark 1 year ago Just finished listening to the entire episode on Spotify & Damn it started a war of neurones in my brain. Sure now I don’t need any pre-workout boost. Thank you once again for everything that you are putting out for all of us to be better. Can’t wait for the next episode.. Excited🤪 7 Reply 4 replies @magicfitzpatrick @magicfitzpatrick 1 year ago I’m surprised you haven’t talked about one of the best things you can do for anti-aging. Donating blood should be on the top of your list. I would love to hear you talk about the benefits of donating blood. 7 Reply 1 reply @cherylsimon7619 @cherylsimon7619 1 year ago Love it! Skin aging is what I've been waiting for!!! Can't wait to hear what you have to say on the next podcast🙌🙌🙌❤ 11 Reply 2 replies @ironmaidenfitness654 @ironmaidenfitness654 1 year ago I would love to hear more about whether GLP-1 is similar to metformin or a good idea to increase health span 2 Reply @quaterman2687 @quaterman2687 1 year ago (edited) I would like to hear about the new studies on resveratrol that show it has no positive effect. And even takes away some of the positive effects of exercising. Could you discuss it in one of the future episodes? Would be great! 8 Reply @sharonsullivan3322 @sharonsullivan3322 1 year ago Rheumatoid arthritis, and sexual performance as we age. Thank you. Podcast very intriguing. Keep it coming. Have fun in Utah! Reply @Dr_Dieta @Dr_Dieta 1 year ago Please take a look at Diazoxide neurological and antiaging benefits. 🙏 It's well studied 6 Reply 3 replies @eggmendy @eggmendy 1 year ago Wonderful, wonderful episode, as always. So informative and well-presented! Thank you for doing these. Reply @user-sb9ml1ef4q @user-sb9ml1ef4q 1 year ago The idea from the book that "aging is a disease and a treatable one" opened my eyes to the possibilities and I'm fascinated since. Reply @igalbog @igalbog 1 year ago As always, interesting to watch and learn about the cutting edge in anti-ageing. Thanks David and Matthew! Dr. Sinclair is looking younger than usual lately - any recent changes in the protocol? 5 Reply 2 replies @DianeandGeorgeExplore @DianeandGeorgeExplore 1 year ago Dr. Sinclair, we are SO grateful for the work you are doing and sharing! Would you consider discussing how far off we are from being able to grow heart valves using a person's own stem cells? My husband was born with a bicuspid valve (and so was his father). He will eventually need a valve replacement, but because his immune system is so strong, we are concerned that his body will reject a mechanical or animal valve (as his father did). Can you refer us to someone who is doing work in this field? Reply 1 reply @Aratohn @Aratohn 4 months ago Thank you David & Matthew, such awesome podcasts Reply @Freed0mOfS0ul @Freed0mOfS0ul 1 year ago I was gonna take BPC-157 (Body protective compounds) for joint inflammation, I found out they are really act like a HGH effect with Angiogenesis , which literally creates new blood vessels that will heal organs , etc. etc. but the risk of cancer goes up , because cancers grow and get destroyed , but if we ever were to get cancer , added blood vessels could add to tumor growth as well as other diseases 4 Reply @sciencensorcery @sciencensorcery 1 year ago As a child, I was growth hormone deficient and underwent GH therapy for most of my adolescence. Aside from catching up growth and development, people who are growth hormone deficient (whether as children or adults) take GH because being deficient puts us at higher risk for lots of major health issues and risk factors including visceral fat, high cholesterol, osteoporosis, cardiovascular issues, etc. So I was surprised to hear Dr. Sinclair say that populations with lower GH have fewer health problems. I'm also curious now: I understand his point about those who take GH recreationally or as a "body hack", but for those of us for whom it was/is medically necessary, what effect does the later-but-accelerated development have on us in terms of overall longevity? I was a late bloomer but developed pretty quickly when I did. I'm 40 now and am usually told I look much younger which seems like a good sign, but I'm wondering what effect the GH deficiency and treatment might have had on things. Has there even been any research on this? I feel like whenever GH is discussed even among scientists it's always in the context of recreational/elective use and it's hard to find information relevant to my situation. (I previously left this comment on your appearance on the Huberman Lab podcast but never got a response so I'm leaving it again here!) 31 Reply 20 replies @LianaBuzea @LianaBuzea 1 year ago (edited) Okay, so episode 6 hopefully will be on hair (re)growth too. This is a big issue for me right now. Perhaps for many other women too. I will keep in mind about GHK Copper (I hope I spelled that right). It was mentioned halfway through this episode (and the warning about peptides and their negative side-effects). Thank you! 🙏 12 Reply 4 replies @joeyfunk4327 @joeyfunk4327 1 year ago Can’t tell you how many people I’ve recommended the book Lifespan too it was great. Very excited to see how well we can Amplify these Sirtuin genes 1 Reply @rcjacksonbrighton @rcjacksonbrighton 1 year ago I would LOVE to hear if they have done any kind of research on humans + ageing re some of the more advanced meditation techniques that can be practiced. I’ve personally had some very interesting experiences where energy has surged through me feeling as though it penetrates all my cells to the point of euphoria. It’s very powerful and I can achieve this daily by doing my practice. Along with living in a state of peaceful loving kindness and open hearted ness which physically feels very good moment to moment I can only imagine this must have a positive impact on ageing? Maybe not. I’m sure there’s some studies currently focusing on this however I can imagine it’s harder to measure as it can’t be done on mice. Or maybe it can be?.. Reply @larryshepperson3993 @larryshepperson3993 1 year ago ive been a fan for a long time and this is the best one two punch in longevity.Thanks a million keep up the great work Reply @Aman.Akshay.Sharma @Aman.Akshay.Sharma 1 year ago Great message at the end, thanks Matt and David for this episode 1 Reply @jawadkarim6615 @jawadkarim6615 1 year ago Thanks unlimited.... awesome and greatest lecture ever in the whole world !... I am so lucky that I could watch your channel. thanks unlimited again 1 Reply @daronleblanc3875 @daronleblanc3875 1 year ago Great discussion!!! Been a fan since your Rogan interview. Ready your Lifespan book 3 times, Can't get enough of Mr. DS Reply @ottot3221 @ottot3221 1 year ago I had a low testosterones level but no libido problems' (thankfully) but I had hot flashes (I'm male) and osteoporosis due to it. There was no cause found. Due to injections and supplements it improved a bit but my risk of prostate cancer heightened. Then I started to do OMAD and now I don't need the injections anymore. My bones are becoming better and although just 0.1 under what is needed I have almost regular bones. Never thought that could happen. 15 Reply 6 replies @robsolo4024 @robsolo4024 3 months ago I became legally blind after my pituitary tumor was removed I am praying that an intelligent man like this can come up with something like a peptide or stem cell that can regenerate my optic nerves that were damaged Reply @patrickday4206 @patrickday4206 1 year ago Yamanaka factors have come so far way faster than I expected when I was first reading his research I thought it was going to be 10 or twenty years to make any real progress because of cancer. 1 Reply @Ccowdog1 @Ccowdog1 1 year ago You both are lovely! Lol 😆 thank you for telling us what doctors don't- please do one on menopause! 5 Reply 2 replies @commonomics @commonomics 1 year ago I’m so excited for the weekly releases, I don’t put that kind of value into any other channel 4 Reply @ainsleyameerali7622 @ainsleyameerali7622 1 year ago Love this !!! Thank you dr David!!! You rock !!! 2 David Sinclair Reply @twoheartshomes @twoheartshomes 1 year ago I love David. I listened to most of the podcasts he was on. Did anyone notice that hes more on the be cautious side of testosterone and GH compared to some of the other podcasts he was on? If this was my first time listening to him, I would second guess taking test and GH. Its odd that he kind of switched his stance on it, or maybe I just misunderstood him. When he was on Ed Myletts 1st podcast it sounded like he was all for it. Reply @jostarrrrrr @jostarrrrrr 1 year ago Thank you for this episode , I can’t wait for next weeks! Can you please also cover the effects of BOTOX to the skin for long term use (I’m yet to use as I’m afraid of the long term effects!) 6 Reply 3 replies @richard18219 @richard18219 1 year ago I wish I had seen this podcast earlier, I had been using peptides to deal with an injury that got worse and to boot, I now have arthritis in my hip and big toe. Reply @loudboomboom @loudboomboom 1 year ago I’d love to hear any progress on restoring dental health and whether or not teeth could be regrown. 2 Reply @Chrystabell @Chrystabell 1 year ago David's smile at 42:23 after Matthew's statement is one of great satisfaction! love it 1 Reply @joshuasmiley2833 @joshuasmiley2833 9 months ago $1.99 Thanks! Thank you David. I have been following you for years. I am yet another person you have inspired and positively changed from the inside out! sincerely, you are appreciated! Joshua, Pedro, Smiley Reply @delishme2 @delishme2 1 year ago Wow I was wondering if they offered a discount. 25 % is great. I'm just about to get back on Resv, Berberine and NMN. I've been using senolytics sparodically, and during pre and post vaccine. After a year off, feeling like crap tbh 😆, so thanks for making feel human and hearing you did the same at some point. I do remember how fabulous I felt a year ago. This time I want to do full bloods, and track properly not just anecdotally. Thank you 😊 ✌️❤️🇭🇲 Reply @ralucasimpleliving @ralucasimpleliving 1 year ago Love this podcast, also bought your book, i'm enjoying it very much 1 David Sinclair Reply @natalyamarcus3165 @natalyamarcus3165 1 year ago Thank you so much for your webcasts! Do I not need to take collages supplements since I take NMN, Reservatrol, vitamin D3 withK2, and metformin (about to start)? Theoretically, if my body thinks its "younger", it would produce collagen in abundance? 1 Reply @lorismith7870 @lorismith7870 1 year ago Most definitely! I have found that in my city (Pittsburgh, PA), which is primarily a traditional medicine community, the majority of physicians are very hesitant to prescribe HRT and claim beyond a certain age, your risk to develop cancer is very high. I know this isn’t supported by current research. Also, there are few functional medicine practitioners who also have MDs - a background I am seeking so I can receive advisement from both perspectives. My DO wouldn’t even consider prescribing bio identical HRT and told me I should find a gynecologist who would. Even these practitioners are very hesitant and keep referring to older research in their explanations. This is SO very frustrating, and leaves many women struggling to find care that could prevent many downstream problems. Reply @stylebase @stylebase 1 year ago What about menopausal women and HRT? Would be interesting to hear about menopause and aging, maybe specific advice for pre and post menopausal women. 107 Reply 28 replies @NicoSpeaking @NicoSpeaking 1 year ago My main takeaway today --> A real and sustainable solution to survive the zombie apocalypse - "brains to go" ... I love this PODCAST! Makes me feel smart. Haha 1 Reply @bellakrinkle9381 @bellakrinkle9381 2 weeks ago (edited) As I have previously read, yes we all have stem cells in our bodies; when we are 5 years old, or still a child, those stem cells are still viable. At 60 or older, they lose their healing punch. Extracting stem cells from our bodies will have limited use. I will now listen to hear your thoughts. Thank you for covering stem cells and more! Is the use of pluripotent stem cell use still illegal in the US? The Christian Right Wing is still influencing health care Policy in the US?! Of course several counties throughout the world make use of Pluripotent stem cells. I think Ukraine was developing Stem Cell Injections prior to this US intentionally created this Proxy war against Russia. Biden and his son have dirty hands! If people truly understood our world they wouldn't be so confused. So SAD. ( - now I'm going to start this podcast again; sometimes I can't shut my brain off!) Reply @stockstudy8633 @stockstudy8633 1 year ago Hi David, I studied your book and have been using NMN, etc since Feb 2021. My stem cells have been banked and I have 1.4Billons of my cells IV'ed and IN'ed in my body since 2020. Reply 1 reply @squirt3179 @squirt3179 1 year ago (edited) I’m curious as to when inside tracker and your podcasts will include estrogen and other female hormones in their bio markers. I am 59 years old and a powerlifter, my inner age scored 9yrs younger than my biological age. My testosterone levels were even optimal, however the SHBG levels are an issue and I am sure not allowing me to optimize the testosterone I have. I sincerely hope more female hormones will be included someday? What can we do naturally to increase estrogen levels ? I’m currently investigating this and possibly HRT and would love your thoughts. Menopause isn’t healthy for any woman and affects aging. Thank you for all you do! 44 Reply 7 replies @stephiegetsit @stephiegetsit 1 year ago I am loving this series. Currently I am on my second regimen of Fiesitn (hit and run method) I know ysaid it's still experimental however I have been scathing of Damage and repairing for agent orange poisoning for decades. Doing rather well at it. So I have some savy and knowledge. About what I am doing. Reply @huangwee3465 @huangwee3465 1 year ago This is very insightful and straightforward. Thanks to both the speakers 1 Reply @Barbarellee @Barbarellee 1 year ago Maybe any interest in discussion on microchimeric fetal-derived placental cells rejuvenation and effects of parity on longevity? Awesome work! :) Reply @stefandaniel4216 @stefandaniel4216 1 year ago I love you David, i can‘t wait to put my hands on your book ( Lifespan) i already apply most of your advices, but i take it slowly, currently eating 2 meals a day instead 3… 7 Reply 2 replies @armieflores6064 @armieflores6064 1 year ago So thankful for great information and very interesting podcast Reply @explorersoftheworld1193 @explorersoftheworld1193 1 year ago thank you for very valuable and useful knowledge, I would be interested in the topic of fertility in women, how to care for it and whether it can be kept Reply @Mysteroo @Mysteroo 1 year ago Frustrating that I can't take metformin without a prescription. Would love to try this out Reply @angelinesarol5616 @angelinesarol5616 1 year ago love your pod cast Im 56 and look and feel 36 Topics you cover so fascinating and your partner covers every detailed information Reply @shelchicago8997 @shelchicago8997 1 year ago David Sinclair just aged backward by a week while I aged forward waiting for another episode. 9 Reply @fiaflodtrollslanda2484 @fiaflodtrollslanda2484 10 months ago Thank you! I love these videos! This is sooo interesting! Reply @markpettus6929 @markpettus6929 1 year ago As the great 20th century philosopher Yogi Berra once said, "the future ain't what it used to be". This is a very exciting time in biomedical sciences. Would be very interested in your thoughts on the future of "quantum access" therapies that re-engineer the quantum morphogenetic fields that are the basis of our material blueprint. This, I believe is even more 'upstream" medicine. 1 Reply @brianstarr3184 @brianstarr3184 1 year ago (edited) Good morning, Matt. You have a John Heilemann-esque vibe. Take it as a compliment. I think you do a great job of co-hosting, asking enlightening questions and keeping the conversation flowing. David is pretty good, too. Signed, Matt's mom Reply @juliesnder1080 @juliesnder1080 1 year ago Hi David What an Interesting podcast. I have followed your Work for at long time. I would Love to hear more about how Women can apply these strategies. I’m a female Who is In the reproductive age and would like to start a Family soon. But many of the recommendations that you mention is proably not suitable for pregnancy? or can it be combined. I’m refiring to the supplements you mentions and the fasting. Reply @tycom55 @tycom55 11 months ago Great show. Could you please list the plants you call distressed greens Thanks Terry Reply @victoriae372 @victoriae372 1 year ago Hello Dr. Sinclair, thank you for your program this week. I have a question of you have time to respond. You mention fasting to stress the body as a anti-aging treatment. Does that extend to ingesting or rather not ingesting liquids? Is dehydration not the same kind of stressor? Thank you for your response. Reply @orion10x10 @orion10x10 1 year ago We're in a golden age of podcasts between this and Andrew Huberman podcast 2 Reply @thatchessguy7072 @thatchessguy7072 1 year ago Thanks for making this video series! 2 David Sinclair Reply @wigglywrigglydoo4735 @wigglywrigglydoo4735 1 year ago What roles do our vagus nerves play on immune system, digestion, nervous systems etc? Especially when the vagus nerve (which cannot regenerate) is compromised by accidents or impinged through the now common, C spine curvature loss? Is it worth integrating cervical spine ligament regeneration into the science of aging healthily? Reply @elensayista8988 @elensayista8988 1 year ago Fascinating idea that of HGH + diabetic drugs to reverse aging + improve physical performance. One thing I noticed for facial aging is if you want to reduce wrinkles or dark circles you need not be losing fat at the same time, or preferably even increase calories. Why? Its seems that whatever topical therapy you apply can dry your skin if you dont have fat to sustain it. I even use honey+curcumin+green tea, which isnt supposed to dry, and it still dries if I dont take care for it. Btw if it dries then your face looks more aged not less, thats why its an important issue and challenging the idea that we always need to decrease sugar to look younger. 1 Reply @desnicolaou7966 @desnicolaou7966 1 year ago I am a peri-menopausal 51 year old woman. I would appreciate it if Dr Sinclair could talk abt the menopause & how we can help ourselves maintain good health. I am getting conflicting advice abt taking HRT & I am unsure abt what I should do/take. 1 Reply @Articulate99 @Articulate99 1 year ago Always informative, thank you. Reply @thestreamoflife1124 @thestreamoflife1124 1 year ago I have been on hormone replacement therapy for decades. I'm 80 now and do not look my age. Most think I look about 60. Hormone replacement therapy has been my life saver .... Reply @mirusvet @mirusvet 1 year ago Thank you very much! Looking forward to the next episode! 2 David Sinclair Reply @pNHGpNHG @pNHGpNHG 1 year ago THOUSANDS of THANKS So Much for Dr DAVID SINCLAIR + Mr MATT LaPLANTE * for your Unlimited + Immense + Continuous contributions to Humanity Prosperity. Those Valuable TIMESTAMPs are extremely useful. Reply @ligiasommers @ligiasommers 1 year ago Best podcast !!! And I study a lot ! Helpful and hopeful.⭐️⭐️⭐️⭐️⭐️🙏🏻❤️‍🩹✨🌹 Reply @user-wv9ss2hk8k @user-wv9ss2hk8k 2 months ago So wish that there is subtitle. It would be immensely helpful for so many of us. We are constantly pausing and rewinding.😢 1 Reply @dailybibleverses4903 @dailybibleverses4903 1 year ago I wish you could speak about other supplements that promote growth hormone like arginine,ornithine, niacin, choline, tryptophan, melatonin, etc. Reply @katebruno9255 @katebruno9255 9 months ago Thank you for sharing such valuable info. My 18 year old daughter has a brain tumor (meningioma) and it is currently inoperable due to an active vessel running thru the tumor. Do you feel exosomes, stem cells, or peptides could offer some hope for shrinking her tumor? Reply 1 reply @sergelachapelle7992 @sergelachapelle7992 1 year ago (edited) I am following these podcasts with high interest... as I am 64 and on TRT, do intermittent fasting, weight train and take NMN and other supplements... (will be adding resveratrol). One issue that was not taken in consideration with regards to aging and testosterone is the fact that life is more than just time. How do you ballance adding life to your time vs adding time to your life. Quite frankly, TRT gave me my life back. My level of energy, motivation and general mood are way up with testosterone.... I would not live like I was before... The added estrogen that comes with TRT is actually cardio protective and has cured my joint pain... Maybe you should stay away of subjects you don't know well or you are biased against... Testosterone can actually be protective against prostate cancer and high levels of testosterone is actually being studies to treat certain forms of prostate cancer... I think your view is a little outdated... The biggest issue I have with all this longevity talk is the fact, it seems, that you have to choose between being vibrant, energetic but short lived or be starving, cold and low energy and live longer... Darn... Everything that makes me feel good seems bad (Mtor activation as I like my meat... testosterone as I enjoy being energetic and productive... ) ... Maybe I am looking for optimization and you are talking about absolute lifespan... Don't get me wrong, I love the podcast... great info to integrate into what I think will be a middle way for me... Cheers 10 Reply 4 replies @GrandJunctionGuy @GrandJunctionGuy 11 months ago The TRT studies that I've seen, including the one you linked have been a wash for mortality relations. Testosterone levels in men has been at a steady decline for the past 50 years. With there being a positive benefit to cardiovascular health, muscle size (particularly in legs, as in the Marcelo Rodrigues dos Santos and Shalender Bhasin study you linked) also correlating to healthy TRT doses, makes me believe there may even be a correlation to longevity. TRT has been shown to increase patient's insulin sensitivity, and even decreases c-reap (Xue-yan Wu 2009). Hypogonadism, SHBG, hematacrit/hemoglobin, estrodial issues have all been shown to be an issue with administration frequency, rather than the drug itself. It is all alleviated with a more in line pulsatile injection frequency of daily, or every other day. Also, it should be noted that Asian men tend to have a 20-30% higher testosterone than Caucasians. Japanese men in particular tend to live 10-15% longer than Caucasians. There are thousands of different biomarkers to examine here, but the correlation is strong enough for me to grant its efficacy, or at least place it under further examination. That being said, low testosterone has been linked to numerous deleterious effects (terrible sleep, hypogonadism, lack of drive, sexual dysfunction, weak muscles, etc.), all of which are correlated with mortality. In my opinion, the benefits for this far outweigh the cons, and could even be correlated with positive effects. 2 Reply @erica7555 @erica7555 1 year ago Thank you Dr David Sinclair! Athletic Green is just delivered to my house now. Appreciate your videos it’s so helpful. Thank you! You look great in that blue sweater.❤️ 2 Reply @Corrans @Corrans 1 year ago I guess a valid question to ask is: how much is longevity worth it if we feel miserable? What I am getting at is that the adversity memetics are generally not fun, don't make us feel too great in the moment (fasting, hot and cold extreme etc) and yet "abundance hormones" like TRT and HGH seem to make people feel so healthy. Would we rather live a bit shorter and feel amazing? Or have longer, more miserable times? Also, as doc hinted, restoring levels to healthy baseline doesn't seem to be problematic? 1 Reply 1 reply @shapdanone @shapdanone 8 months ago Matthew is an outstanding conductor Reply @Lurksin1 @Lurksin1 1 year ago Love this area of research. How do you feel about Wim Hof breathing techniques and the research on improving mitochondrial function as well as meditation, hormesis in general for lifespan Reply @Haliotro @Haliotro 1 year ago Mmmm love medical advice from non-medically and even non-biologically trained guests 1 Reply @rosiek649 @rosiek649 1 year ago First time I’m seeing he looks healthy and skin is glowing only little inflammation on left shoulder and little on left side and front of the elbow. well done I can respect you now. If you’re advocating for your job or what you believe in show the evidence in your body. Reply @leopitre7907 @leopitre7907 9 months ago Sylvester Stallone is 76 and I'm pretty sure has been taking HGH for at least 20 years and still looks fantastic...I believe he probably just uses it to maintain a natural level that he had at some younger age... because he doesn't look like body builders that abuse HGH and get their heads and neck get that big fat headed look from more bone growth. 1 Reply 1 reply @husainialiyu5198 @husainialiyu5198 1 year ago At 75yrs I am. very keen on David Sinclairs achievement in longevity science.i take a lot of suppliment. 4 Reply @chrisknightnaturalwellness9697 @chrisknightnaturalwellness9697 9 months ago Awesome Channel and powerful data!!! Thank you !!! ✨💪🏽😎🤙🏽✨ Reply @heatherschramm @heatherschramm 1 year ago Please address the hormones that are dominant in women also. Women have issues with dipping testosterone, but estrogen and progesterone also have a huge impact on women as we age. 10 Reply 7 replies @dwdwone @dwdwone 1 year ago (edited) I would like to learn more about how the Yamanaka factors work, their relationships with sirtuins and how they are used in regressing adult cells into stem cells. Reply @ChessMasterNate @ChessMasterNate 1 year ago It would be great if the eye treatment could be tried on the cochlea of the ear to stop ear ringing. I blew out an ear in Jr. High, and it has rung ever since. And it has gotten worse. I suppose it is harder to ask a mouse if it has ringing in its ears. I suppose you could wipe out all the little hairs and see if you can grow them back. And check various frequencies. Reply @sonnymatthews5452 @sonnymatthews5452 1 year ago I would like to know David's testosterone levels, and what range would be considered optimal? At what point should you supplement? 2 Reply @gruuvmunky @gruuvmunky 1 year ago Question- what specifically counts as 'fasting' time with regards to the health benefits IE-Autophagy? If you eat once a day at dinner time. That food is digested for quite awhile. If it's still in your digestive system in the morning & affecting your blood levels...then when does the actual fasting time start? Thanks for any info!!!! Love this channel 5 Reply 5 replies @ChessMasterNate @ChessMasterNate 1 year ago Okay, I have watched all the videos thus far, but have heard almost nothing on the accumulation of intercellular junk, and just a bit about junk inside the cell, and what can be done about it. Because it looks to me like this is a major player in the current limits of human lifespan. There is more than one kind of heart disease, and the one killing the 100+ crowd is often Wild-type transthyretin amyloid (WTTA), where transthyretin amyloid builds up in the heart and some other tissues making the tissue stiff, and it becomes very tiring to even stand. 25% of men over 80 already show signs of this beginning. And this is just one of 25 or 30 proteins that can misfold and accumulate in the body. Then there is glucosepane. This Advanced Glycation End Product can't be removed by the kidneys, even if they are healthy, even if the other AGEs can be. This also builds up stiffening tissues and is implicated in a number of aging diseases. And what about lipofuscin? Maybe that will be covered when skin is the topic, but this crud is also in the brain, muscles, the heart and other internal organs. Then there are the studies about the intentional conjoined mice, where they saw the health of the older mouse improve, and the younger mouse go downhill. And after a series of studies they determined that it was chemicals in the blood of the older mouse that was the problem, and by plasmaphereses they could restore the older mice to health. That to me suggests that there are accumulations not just in tissue but in the blood. I don't know if healthy kidneys is the answer to that or if there are things the kidneys can't do anything about, like that glucosepane, which needs periodically removed. Then there is scar tissue. There are injuries within the body from infections and whatnot, and the body chooses speed over accuracy during repair, but if you live long enough, these sloppy repairs will also accumulate. We also accumulate infections that the body can't ever completely eliminate. Older people have much more of these than younger people. Things like toxoplasmoses, and cytomegalovirus. Ultimately, I don't think these things are benign. It is likely they wear down defenses, or promote diseases we haven't yet tracked down to them. I sure would like this accumulation topic discussed. 4 Reply @dahsk7872 @dahsk7872 1 year ago So excited to listen to this one. Thx Dr. Sinclair Reply @stevegerrior7259 @stevegerrior7259 1 year ago Willing to share any ideas on how to decrease the deleterious effects of T supplementation for those of us who clinically need it due to a disease process? Reply @sunmoon-84 @sunmoon-84 10 months ago How is the medical intervention for longevity studies going? I would love an update. Reply @thestreamoflife1124 @thestreamoflife1124 1 year ago I'm drinking athletic greens for 3 months. Great product Reply @frontrowtennis @frontrowtennis 1 year ago Are there any supplements that can help with Osteoarthritis in the knee due to multiple meniscus surgeries and a lifetime of sports? Thank you! Reply @ellaborelli2355 @ellaborelli2355 8 months ago He looks so young. He is not just wrinkle free. His face has the fullness of youth. Reply @zedek_ @zedek_ 7 months ago So these things will almost certainly require input from my doctor, as you mentioned, but I'm unclear as to which ones are currently available to me for treatment now. Reply @sirt1353 @sirt1353 1 year ago I started really praticing and supplementing for anti-age due to hair loss. Do you know what could really help with help regrowth and regeneration? 3 Reply @fit-humble @fit-humble 1 year ago (edited) I have a question regarding fasting. Does fasting like 16 hours a day enhance your metabolism, testosterone and GH levels? Do we lose muscle mass while fasting for this peroid of time? Reply @dominiquezivkovich-brady @dominiquezivkovich-brady 1 year ago Please note that Levels is currently available in some American states only. I’m in New Zealand & desperately want it! 😂 Reply @gbaham521 @gbaham521 1 year ago Can you tell me about Proline, Lysine and Choline? I was told these were key amino acids to take if you’re wanting to generate collagen in your body. Reply @stevenj6421 @stevenj6421 1 year ago I can't even explain my gratitude for having the Most modern science, cutting edge know-how and knowledge and the ABILITY to be shared to the mass populace without being chewed and misinterpret by for-profit news. This IS the greatest #realized #purpose of the #internet itself to #spread #knowledge! Thank you and my sincere gratuity #DavidSinclair 1 Reply @camiloandresleguizamon3624 @camiloandresleguizamon3624 1 year ago Excellent podcast Reply @kurthoffmann7160 @kurthoffmann7160 1 year ago (edited) What would happen if you cycled on and off trt and hgh so that you get the short term benefits, but then stopped those and go into a longevity mode where you do minimal mtor generation and lots of sleep etc..... so cycling between abundance memetics and adversity memetics... so you get gains during abundance mode and then maintenance mode during adversity mode, then cycle back into abundance mode and do it all over again. 6 Reply @viviancastro2783 @viviancastro2783 1 year ago May I suggest you change the title so you put the number of the episode so that we don’t have to open more to figure out which episode it is? Thank you! Loving it! Reply @creightonfreeman8059 @creightonfreeman8059 1 year ago I hope your eye reprogramming human clinical trial progresses rapidly. Both my parents are losing their eyesight to macular degeneration and there is currently no real treatment, only drugs that slow the damage. If your reprogramming Yamazaka gene therapy can do for human eyes what it does for mice eyes it would change lives. Reply 3 replies @ChrisHogan111 @ChrisHogan111 1 year ago I wonder if you could induce pluropotence in cells with just the mRNA of the Yamanaka factors without getting some of the deleterious effects. Reply @Kikwatz @Kikwatz 1 year ago I must admit, our good friend (and my personal idol) Dr. Huberman does look significantly older (but also more "androgenic"), since he started his "TRT" (I think he startet about January 2021)... Reply @verderne @verderne 1 year ago Thanks you guys! Blessings. Reply @Sinasi08 @Sinasi08 1 year ago Hey Dr Sinclair, could you please invite Dr Thierry Hertoghe on your podcast to talk about hormones and longevity? Thanks Reply @patrickday4206 @patrickday4206 1 year ago It's nice listening to people that really know their stuff. It's been about five years since last diving into peptides. I've even talked with a biologist on a dating profile about how incredible peptides could be for so many health issues she criticized me said I didn't know what I was talking about. Lol I've taken a few. I hope the fda seeks advice from people like David Sinclair before blanket banning substances. Reply 1 reply @angeldahnke3496 @angeldahnke3496 1 year ago Brilliant. As always! Reply @rosadellacasa1201 @rosadellacasa1201 1 year ago Can gene therapy be used to regenerate healthy liver tissue or turn cirrhotic tissue into healthy tissue for non-alcoholic cirrhosis? Are there clinical trials for this? Where do I find them? Reply @WFNOIR @WFNOIR 10 months ago we must take seriously research to longevity and invest more to it Reply @rafaeln6341 @rafaeln6341 1 year ago So what's the final advice take testosterone, hgh or peptides? Or don't take them? Or takemods? and monitor sides and counter act sides with other meds? Reply @JoeyFirestone @JoeyFirestone 1 year ago What’s your thoughts on umbilical-cord derived multipotent mesenchymal stem cells (MSC's)? Reply @melindastefan2265 @melindastefan2265 1 year ago I really like to listen to the lifespan podcast, but as a woman I feel women data are invisible in most of the researches. Could you please Dr Sinclair apporach some topics from the aspects of women? Especially when you talk about hormones like in this episode? It would be fab to hear about more similarities and differencies if there are any between a female or male body in terms of ageing! Thank you and congrats! And by the way, I’m Hungarian too as your grandma😊 17 Reply 1 reply @lorasolomon5112 @lorasolomon5112 1 year ago Great video info, love your channel...! Reply @BrianAether @BrianAether 8 months ago from a hoslistic perspective this is interesting. Its easy to remove wrinkles, add muscle mass and improve organ function. where science is going wrong is its neglecting human kinetics from a perspective of what the body does to protect itsself in correlation with how the body moves and how exercise might not be beneficial not be beneficial in some aspect the same way growth hormones dont work on some. Its really all about FLOW, and i could prove this to you in just one session. Reply @bojanlukovic4774 @bojanlukovic4774 1 year ago I would like to ask about supplementing with Pterostilbene. Dr. Sinclair hasn't mentioned it, but he mentioned Resveratrol, Quercetin and Fisetin. Pterostilbene is, I think, in the same group. What is his opinion about it? 1 Reply 1 reply @joseaugustodossantossilva1149 @joseaugustodossantossilva1149 1 year ago there is any correlation between tattoos and risk for your health in long term? I'll be glad to get an answer! thanks Reply @Skyandgrace @Skyandgrace 9 months ago Peptide bioregulators have changed my life and there are plenty of studies backing their safety. I am not a fan of injectables though Reply 1 reply @cynthiarucker1442 @cynthiarucker1442 1 year ago Amazing and wonderful. Thank you!! 1 David Sinclair Reply @bobparquet @bobparquet 1 year ago If we don't reset our "EGO", extending our life will only do worse damage than we have done so far, believe me .... 1 Reply @aaroncatolico7550 @aaroncatolico7550 1 year ago It shouldnt always be strictly quantity of life, but quality of life as well. Some people have serious health issue due to lack of testosterone or hormones as to why they get prescriptions to improve the quality of their lives & possibly even quantity depending on what their health problems were. Having too low of testosterone could cause many types of health problems. 1 Reply 1 reply @LamNhatHuyIELTS @LamNhatHuyIELTS 1 year ago It's interesting to think that one day we might look as young as our children. 1 Reply 2 replies @nothinghereligma3363 @nothinghereligma3363 1 year ago I want a crossover between Dr. David Sinclair and Dr. Steven Greer 1 Reply @syrupgoblin4920 @syrupgoblin4920 1 year ago How long are we thinking until going in for a stem cell treatment is affordable for almost everyone? Reply @casalderliesten2607 @casalderliesten2607 1 year ago Is there maybe something you can tell us about how drugs like Methylphenidate (ritalin) might effect longevity? Reply @auroramarialopez @auroramarialopez 1 year ago (edited) What is the name of the company/ which is the company for exosome diagnosis that you were mentioning?thank you so much 🙏 great podcast Reply @ivanandreevich8568 @ivanandreevich8568 1 year ago Fastest longevity channel to 100K. Congrats! 1 Reply @maxperata @maxperata 1 year ago LOVE YOUR PODCAST... Reply @dropclutch1 @dropclutch1 11 months ago I know they have to tread lightly and not recommend actually doing some of these promising new treatments and taking non-FDA approved supplements and drugs. But not all people have the time to wait, so it seems there is kind of a sliding scale of risk vs reward for each individual to decide what they want to try. My other concern is that once we have all the scientific confirmations of efficacy and safety, once there is FDA approval and the drug companies get their patents some of these treatments may be out of reach for many people who don't have a lot of money. Is my pessimism over exaggerated? 1 Reply @dianavaldez3371 @dianavaldez3371 1 year ago Love the content! Ty! ❤️ Reply @pinkberrydigital2237 @pinkberrydigital2237 1 year ago The FDA just doesn’t want us to take our health into our own hands. Period. 8 Reply 1 reply @samot-sariniokee551 @samot-sariniokee551 1 year ago I will be turning 74 on March, a Filipino and has been taking NMN for 3 years now plus several supplements. How can I send you my story. I believe I could be a good example (anecdotal) being on the 4th quarter. 1 Reply 1 reply @manikdesign @manikdesign 1 year ago Podcast starts at 5.30 1 Reply @andyatmosphere @andyatmosphere 1 year ago David is probably one of the best in his field. BUT you can tell he’s not a fan of HGH or increasing testosterone for the purposes of muscle gain. He don’t like to workout, he’s not a fan of body builders… even though there’s NO scientific evidence that HGH (in the long term) IN HUMANS causes long term health problems. Reply @marjake3147 @marjake3147 1 year ago I am physically disabled and unable to exercise. What can I do to counteract this? Reply @Skyandgrace @Skyandgrace 9 months ago I know too many who have suffered from the long term use of metformin. It’s not great for the liver. I much prefer working with peptide bioregulators and enzymes Reply @leeferguson1077 @leeferguson1077 1 year ago I am still confused by the fact that David says he drinks athletic greens every morning but also states that he fasts every day? Can anyone clarify? Great podcast by the way 👌🏻 Reply 1 reply @lukekennedy2410 @lukekennedy2410 1 year ago Dave, as a fellow Australian I'm not alone when I ask how we can use inside tracker from Australia without using an American address? Reply @joeyfunk4327 @joeyfunk4327 1 year ago TRT leads to muscle growth and typically more food intake to support growth which is the opposite of caloric restriction 1 Reply 1 reply @victorkoehneramalho865 @victorkoehneramalho865 1 year ago Studies show that fasting for 24, 48, 72h can spike growth hormone up to 3 times; I wonder if this effect can compensate for the age reducing autophagy effects... And in the end we get 0 reversed years Reply @MinMin-kv3rv @MinMin-kv3rv 1 year ago Every Wednesday now is like xmass morning! Running to check what gifts I got!!! Amazing! 6 Reply @diseasehealthdiets136 @diseasehealthdiets136 1 year ago Thanks! dr David for amazing apisodes. Reply @chrislapiana8392 @chrislapiana8392 1 year ago Would you please read someone's DNA and Blood work from inside tracker? It would be fascinating seeing how you think / providing insight. I would offer up mine 1 Reply @TotalyRandomUsername @TotalyRandomUsername 1 year ago So you start a channel and get over 100k subscribers in one month. That is astonishing! :) But i am very happy about this channel. Reply @gotomars2969 @gotomars2969 1 year ago Very very exciting times. 3 months for every 1 year lived right now…the near future is amazing. Reply @heracles89 @heracles89 1 year ago Longevity / biotech will be the biggest industry we have ever seen in my opinion 3 Reply @Martin-ec9mh @Martin-ec9mh 1 year ago (edited) ❓In a previous episode, David mentioned that too much iron is bad. But how much iron is too much? What is the maximum level for Hemoglobin [g/dl] and Ferritin [ng/ml]? Which values are optimal (for an adult)? 3 Reply 3 replies @estilusafter1239 @estilusafter1239 1 year ago Por favor pueden traducir los videos al español o poner subtítulos? Yo no se ingles solo comentó en español porque ahora YouTube tiene traductor de texto espero que lean el mensajes Saludos Reply @erickminor @erickminor 1 year ago I would wager that most older adults would rather feel good today as opposed to just living longer. Reply @jordanminnix9698 @jordanminnix9698 1 year ago Went on trt at age 26 and i cant imagine going off of it. Low t is terrible. Reply @Viertelfranzose @Viertelfranzose 1 year ago I am just surprised why the FDA seems have never big problems with Glyphosate. 1 Reply @andrewwalker8985 @andrewwalker8985 1 year ago The HGH discussion skipped over the TRIM and TRIMX trials done by Greg Fahy, and showing age reversal with epigenetic clocks. Shame - I really wanted to hear Davids view on that work 3 Reply @maribelurquieta6595 @maribelurquieta6595 1 year ago Podrías poner en Español ,por favor 🙏🏻 me gustaria😔que puedas hacerlo en español 1 Reply @gotomars2969 @gotomars2969 1 year ago Question David - what about periods of upper quintile testosterone & periods of lower quintile to allow adversity, but also allow periods of feeling better & sports improving? Say 3 months of one, 3 months the other, and so on. This variety is easily done with TRT. Reply 1 reply @ciarog6116 @ciarog6116 1 year ago (edited) Are you referring to peptides that were made in Russia and now available here? These are said to heal the heart,liver, brain and other organs. What do you think? They are said to extend lifespan by 30%, but I think that means expected lifespan of an already ill person. They are made from animals or synthesized. 1 Reply @peterz53 @peterz53 1 year ago @52 min on thymus regeneration: See research of Janet Lor which showed that older (65 to 80) who cycled alot over many years preserved their thymus output of T cells and had immune function of people decades younger. It's also known from other research that exercise increases NAD+ and modulates other metabolic factors towards younger states. 1 Reply 1 reply @mikhailtronik4322 @mikhailtronik4322 1 year ago Holy shit man, you guys are Gods. Reversing aging in dead man's brain cells, sounds exciting! 1 Reply 1 reply @tomjackson8955 @tomjackson8955 1 year ago I would take DHEA,HGH and Mifoerm 5min a in to a ice bath, maybe 7 to 10. Take it when the blood flows back to the core. Reply @CJ-yk3yk @CJ-yk3yk 1 year ago I banked my child’s cord blood almost 12 years ago. So many told me that I shouldn’t but it’s an insurance policy as far as I’m concerned. My doula told me that she didn’t recommend it as it probably won’t help. I told her I hope my house doesn’t burn down, but I still have fire insurance just in case. 😜 Reply @clearlyaudible @clearlyaudible 6 months ago You need to take B12 supplement along side Metformin, just a quick note. Reply @Ondrej.U @Ondrej.U 1 year ago Serious question: Has anyone studied or even considered mTOR activation cycling? What I mean by that is high mTOR activation for couple days and then low activation. The reason to do this would be to build muscle for several days, then rest and clean up the body. From everything I know about mTOR and autophagy (very limited knowledge), it seems to me it's not necessary to have mTOR downregulated and autophagy activated constantly. What I'm trying to test is if there's upper limit of autophagy activation or some point where longer autophagy activation has diminishing returns. The other limiting factor is how long it takes for autophagy to activate (2-4 days?) The main variable is length of each cycle, it could be days, weeks or maybe even longer. I know about intermittent fasting, which is great, but it seems to me that autophagy activation requires longer mTOR downregulation. eg. I cannot eat large steak every evening and expect it to work. There's also a reason why Dr. Sinclair stays on low meat diet over longer periods of time. Why even think about this? Building muscle has a lot of other health benefits, especially in elderly people. Dr. David Sinclair, could you please elaborate a bit on this topic? Thank you! 1 Reply @NRNF1776 @NRNF1776 1 year ago Its funny... I see this video is up, and I know immediately what my husband is doing. Its like magic! 1 Reply @TheWelshmatt983 @TheWelshmatt983 1 year ago Damn I was hoping he was going to say the use of TRT and HGH was a good thing for aging Reply @katieobeid5457 @katieobeid5457 1 year ago Plz talk about HRT in future podcasts. Reply @davidneedham6330 @davidneedham6330 1 year ago David I’m taking a supplement that claims to be pure NAD. Is that even possible and if so is it worth it? I’ve been combing your videos and I’m wondering if I’ve been had. You take the precursor obviously for a good reason. Reply 1 reply @mikelance7175 @mikelance7175 5 months ago Sylvester Stallone looks like he’s in great shape. He’s been taking growth hormone testosterone for 50 years or more. 2 Reply @rustybolts8953 @rustybolts8953 4 months ago Now I wonder how all this fits with Dr. Michal Levin''s research in "Bio-electricity" and "Morphospace" ? Reply @orionbaden-powell1496 @orionbaden-powell1496 1 year ago pretty sure I was told dhea was beneficial for menopause but the mayo clinic says do not combine with estrogen, which I am on, I am also prescribed testosterone Reply @allyjhughes @allyjhughes 1 year ago Can you talk about hair? Male pattern balding and grey hair? And also talk about Finasteride use and its long term effects. 4 Reply 1 reply @Adhara740 @Adhara740 1 year ago Can you talk about the cjc1295 peptide shots? Thanks Reply @justmeandmy @justmeandmy 1 year ago Do people who "reverse aging" remain dependent on the supplements to maintain that youth? If they stop taking them are the effects rapidly lost, or lost slowly as though they were that lower age? The reason i ask is because true age reversal would mean without taking the supplement you age like someone your age - 10 yrs (for example). Else it's not true reversal, just mimicry and you still have worn out cells. A long while back i heard aubrey de grey talk about how in the future we may actually learn to regenerate youthful versions of our cells so when you make a new cell it might look like a 21 yr old version, not your 60yr old version. Reply @annafrances6883 @annafrances6883 1 year ago Mini human brains = fantastic news for mini zombies (Also for those us us with high predisposition for Alz) Reply @howtodoitbysmoon1597 @howtodoitbysmoon1597 1 year ago my question is that if we reprogram the cells how do regenerate cells that are lost such as AD disease, do they reprogram the stem cells and they know where to go? Reply @lucasgerhard @lucasgerhard 1 year ago can you say something about how the fluorine in water affects us? Reply @commonomics @commonomics 1 year ago Do you guys think sitagliptin can be used in place of metformin? Reply @lucbraet5301 @lucbraet5301 4 months ago in a short film, can you give an estimation when a full body age reversing (reverse minimal 2 years every year) program will be possible, and if it is possible to buy in for the human test subjects, screw the FDA they are morons anyway who keep the cure in the fridge as long they can, and older people run out of time. i know that you can't see into the future but surely you could give a pretty good estimation/guess . Reply @margaretbachmeier5299 @margaretbachmeier5299 1 year ago Dr Sinclair, Could you Please let me know the Name of the Sleeping Pills that you take. Thank You . Love listening to you. 1 Reply @krisjay1558 @krisjay1558 1 year ago are people who are non-diabetic having success in getting metformin prescription? I did a telehealth doctor thing and after the session he says, "we don't do that", despite me informing ahead of time that was the reason for the appointment. Reply @frenchmontana423 @frenchmontana423 1 year ago guys! when are you going to speak about the skin and hair part of all this?!?! you guys mentioned that you'll go into detail with it! please and thanks 1 Reply @stevebiggs4022 @stevebiggs4022 1 year ago Is there more benefit to using TRT (If monitored and not over done) than not using it? The reason I ask is that I am assuming decreased T is also a major indicator of aging. It seems regarding TRT treatments, you are damned if you do and damned if you don't. Thus, back to my original question, does the benefits of using TRT outweigh the risk? Reply 1 reply @mattgallant6910 @mattgallant6910 1 year ago growth only occurs when you are not use to something 🧠🧬 Reply @bibodude @bibodude 1 year ago I'm little bit confused. In fact, in one side, we are suggested to do intermittent fasting which also increase growth hormone in our body. But in another side, we are told too much growth hormone is detrimental for the our body. Can someone clarify this contradiction? Reply @stuarts5301 @stuarts5301 1 year ago So regarding TRT, how much does it work against longevity? Say my testosterone stays in the 600 range which is middle of the road normal…will that completely undo all my once a day eating and NMN/resveratol morning routine? What would you recommend our testosterone levels be to be in the longevity range? Reply 1 reply @tombillard5264 @tombillard5264 1 year ago not everybody wants to live longer as in past the avg life expectancy, they just want superior quality while they are here. you also leave out that there are ways to counter some of those side effects Reply @quantitradersignalservice5735 @quantitradersignalservice5735 1 year ago My doctor will not give me a prescription for metformin because I do not have diabetes so I'm taking berberine. From what I've read its just as good. Reply @stephenlucier @stephenlucier 1 year ago Brilliant! 1 David Sinclair Reply @jawadkarim6615 @jawadkarim6615 1 year ago Greatest Scientist ever in the whole world *** . Reply @justingirard7476 @justingirard7476 1 year ago What about the elevated GH levels along with fasting? I get confused here Reply @judyfasola3737 @judyfasola3737 1 year ago Dr....😊 forgot to mention... I have Mild aortic regurgitation valve and colesteral a little high... good cholesterol is good not on statins... very active 72 year young lady ...hip osteoarthritis but hasn't slowed me down keep active ... I'm on your protacal ...is this ok for me to do ... Thanks sooo much ❤️❤️❤️ Reply @janlock9579 @janlock9579 1 year ago I am still wondering... when the cheap test is coming ? Last year you said : at the end of this year. I'm on the wait list but impatient. Have been using a great deal of money for several years and it's all on faith. Reply @gstlynx @gstlynx 1 year ago Sinclair doubting mouse data re peptides is rich. 1 Reply @yourcoachbladimirsantos5136 @yourcoachbladimirsantos5136 1 year ago Does anyone knows where david is getting the supplements from? Reply @judyfasola3737 @judyfasola3737 1 year ago Drs.... love your podcasts ....ok please what water filtration do you use...... I've been doing alkaline filter... pitchers ...heard alkaline is bad ...... I'm 72 years young 😊...on your protacal ...but haven't heard you mention water ...could have missed .....also do you take all vitamins in morning or throughout the day ... Thanks again for your input....💕💕💕 Reply @lumeshisthebest @lumeshisthebest 10 months ago I want the reset pill! And my younger brother is blind from star guard disease in the retna. Can we use my cord blood for him? Reply @lucaslimal3 @lucaslimal3 1 year ago Oh Jesus! I had to take a break after the mini human brain part!! 35:00 Reply @russellsimienii9343 @russellsimienii9343 1 year ago "Eunich's have been shown to have longer lifespans..." Oh well, so much for living long Reply @h20no63 @h20no63 1 year ago 100 years from now society will look back and say how was he not more popular than a Kardashian. Reply @edgarjun @edgarjun 1 year ago Taking HCG instead of testosterone will not shrink the testicles, T will go up but won’t work for primary hypogonadism, and won’t work for females Reply @sahilsharma8629 @sahilsharma8629 1 year ago Doctor do you know know about taatwale baba, he stopped aging when he was 33 and when he died at 90 he was same as he was at 33...he stopped aging. You can contact his disciple who lived with him many years. He still living in his cave. Reply @brianadler67 @brianadler67 1 year ago I assume that DHEA is an abundance mimetic (and therefore not long term beneficial even though it is short term beneficial)? Reply @chrisotc6832 @chrisotc6832 1 year ago David mentions getting a good night's sleep is so important for stimulating growth hormone, but personally I find with prolonged fasts my sleep gets really disrupted,.... to me, it seems that prolonged fasts and proper sleep don't go well together.. and is less beneficial? Reply 1 reply @ladonnabellavillalobos9627 @ladonnabellavillalobos9627 1 year ago You are probably gonna laugh at me when I tell you this but after that virus and being in the hospital three months in the ICU they started giving me insulin shots in my stomach oh that was horrible I don’t know why they were doing that I think they was using me as a human guinea pig anyway I did make it through it and gained 200 pounds so I left there with two of me I am 510 but I don’t need to weigh over 300 pounds it only took me six months to get it under control, I guess I can give my opinion here OK in the morning and boiled water I put lemon cinnamon stick basically that’s about it and something else happened did you know that there are only green and brown eyes I’ve had green eyes since I’ve gotten older but I found out that I had a lot of toxins so the lemon water clean my liver so well because the hospital also gave me a fatty liver that the lemon water cleaned your liver I mean you could try to research it and I’m just giving what I did OK not a scientist not a doctor nothing like that I do a lot of research had a health food store that’s it that I grew up in a family with a grandma that made us take certain things to keep us healthy and we never got any whatever them shots are against diseases because my uncle is a chiropractor so I knew they were bad way back then thing I remember the most about what he said was the mercury Kontan I think yeah I’m just going by memory I’m 68 1/2 and that’s when I was growing up, I hope they don’t get upset with me saying things like this on here but I love to help people get healthy they prescribe me the type two diabetes Met Forman and something else but I never took it I read about the side effects I know he suggested that before but you can get rid of it and you can get rid of high cholesterol very easy you need good fats to get rid of the bad fats and processed food has so much canola oil sunflower seed oil all them that mess you up so much and you’ hormones I’m just trying to help women with menopause probably shouldn’t comment the stuff on here I don’t want to get in trouble but always research yourself the Cleveland clinic I think Harvard and a lot of them colleges on their science website I believe have a Lotta information but you got to do the research I’m gonna wait a little while before I take the supplements I see the movie what time where this man started aging backwards and turned into a baby when that be funny if that happened, I can’t help myself good sense of humor will keep you healthy too Reply @AdamPepeWerderits @AdamPepeWerderits 1 year ago At 24 min, with all due respect, Cerebrolysin is actually a brand name and it has several decades of clinical use and research to back it up, it’s not experimental by any means. Reply @TheRealiRgrunt @TheRealiRgrunt 4 months ago Let’s get to important question: can these AAV injection be programmed to give me a 12” reproductive organ Reply @ladonnabellavillalobos9627 @ladonnabellavillalobos9627 1 year ago Play Sinclair I approve inside tracker for sure because you cannot get a decent blood work out from a doctor and they change the range since the 70s so you really don’t know what you are getting at the doctors office Reply @tyyung177 @tyyung177 1 year ago I had an aortic dissection 2 years ago at the age of 19 during water polo practice. With my aorta still torn 12 inches and is continuously opening would stem cell therapy help reguvitating my tissue? Reply 1 reply @ivanislasbe @ivanislasbe 1 year ago good info👏 Reply @PAXmusic @PAXmusic 1 year ago (edited) These guys are fantastic and their expertise in longevity is obviously unrivalled. With that said, they are not qualified to talk about testosterone on a public platform. The understanding demonstrated here was woefully low. Testosterone does not cause prostate cancer. If that was true, there would be high levels amongst teenagers and young adult men. Prostate cancer is caused by localised high levels of estradiol in the prostate. This typically occurs due to lowering levels of testosterone and higher aromatase activity as men age. When a tipping point is reached, prostate cancer will occur. There isn’t even any mention of the importance of progesterone, and how it inhibits the aromatase activity of T to E2. Progesterone also declines with age and SHBG which typically increases will also lower Free T. There is so much more to the puzzle that is endocrinology, that to focus on a couple of pieces of it is dangerous on a public platform. Testosterone is incredibly protective against numerous diseases including prostate and breast cancer and Alzheimer’s. It is a shame they have not given endocrinology the same due diligence they give to Longevity studies, because only urologist and endocrinologist dinosaurs would repeat this old tired dogma now. Professor Edward Friedman has a fantastic book on testosterone for anybody interested. Reply @AthenaTheWolf @AthenaTheWolf 1 year ago 34:06 don’t get on Dr. Sinclair’s bad side 1 Reply @joshuaeisenberger4975 @joshuaeisenberger4975 1 year ago i want to try cerebrolysin so badly i heard so epic stuff about this peptide complex its bonkus. But sadly i need an recipe in germany so im looking forward to get it in the netherlands (this reminds me of my weed days :D) 1 Reply @foxfox-xx3zk @foxfox-xx3zk 1 year ago (edited) Rewatching "Invincible". I was like that's the guy. Lol I think they even said it was a Easter egg. Was an interesting find. 👍 DA Sinclair hahaha 🤯🤣 Though cyborg hybridization seems more in the realm of Elon with nuro link. Funny because Nikola Tesla was featured in the fist superman cartoon. As a mad scientist deathray and all. Though he did actually have plans for one. I couldn't have been the first to notice though. Reply @SeattleCondoSpecialistcom @SeattleCondoSpecialistcom 6 months ago Thanks. Great Content Reply @AamirShahzadwebdeveloper @AamirShahzadwebdeveloper 1 year ago I have a confusion on when you say long term & short term ... if someone starts TRT at 40 if he feels good for 20yrs what else he will need Reply @eduardoaugustosilvestre724 @eduardoaugustosilvestre724 10 months ago (edited) TRT (low doses) and longevity possible ? i'm talking about T between 300 and 800 sinclair didn't mentioned this Reply @shrek4619 @shrek4619 1 year ago It’s not playing God laddies. It’s just making people’s quality of life better. Reply @timothykowalewski3943 @timothykowalewski3943 1 year ago Idk....people like Sylvester Stallone(at age 75) and his celebrity co-horts seem to be aging just fine on all sorts of performance enhancing drugs which would be labeled abundance mimetics Reply @vibhaspalding6457 @vibhaspalding6457 1 year ago This is interesting podcast but the peptides and hgh, trt they talk about is virtually not avaulable in UK. Sone of them still in research and state not for individuals but sold for research. All very expensive. 1 Reply @fatimafreire2841 @fatimafreire2841 1 year ago 😊👏👏👏👏❤️ Reply @carystus675 @carystus675 1 year ago At 22:35 the text reads 'thymus and alpha one', it should be thymosin α (alpha) 1. Reply @nas3426 @nas3426 1 year ago Athletic green sounds good 👍🏼 Reply @sunset8959 @sunset8959 1 year ago I have ordered Athletic greens 7years ago and its still not finished. It just tastes awful Reply @timkunde8572 @timkunde8572 1 year ago How about using t cell therapy for lydig cell therapy and replace trt therapy? Reply @ianlassitter2397 @ianlassitter2397 7 months ago Haven't hear any relationship to HGH doses and the potential side effects. To me when you are talking theoretically without conclusive data you are all but guessing. Someone taking 20 IU a day vs someone taking 3 IU a day will have a significantly different experience. Age also matters…are you 20? 55? 80? Male or female… the fact those things are not fully addressed tells me a lot about the “expertise”. He may know his field but he isn’t addressing many areas and that’s done intentionally to avoid a more realistic conversation. Reply @jefflawrence7707 @jefflawrence7707 1 year ago Any thoughts on gut health & Butyrate? Reply @abdelilahbenahmed4350 @abdelilahbenahmed4350 1 year ago yes, abundance (and money) mimetics is not always a good thing. Reply @m3tzeko @m3tzeko 1 year ago What does the science say about dehydration? Any longevity benefits here? I know its generally bad. 1 Reply 2 replies @couga8888 @couga8888 2 months ago 9:10 So basically to live longer you have to become a eunuch. I chose to have shorter life then. 1 Reply @plantbasedathleterealtor6145 @plantbasedathleterealtor6145 1 year ago Can you do a podcast in HLAB27? Reply @lumeshisthebest @lumeshisthebest 10 months ago I did bank my sons cord blood. Can I be part of your research studies? Reply @kirillknyazev3037 @kirillknyazev3037 1 year ago David looks a bit younger than in the previous episode) 5 Reply 1 reply @damiandamiano3651 @damiandamiano3651 1 year ago "I am not selling you anything", AH Yes its time for sponsors Reply @dikeledimogobe5117 @dikeledimogobe5117 1 year ago My mentor! Reply @stephenr85 @stephenr85 1 year ago (edited) Look at people that have been on TRT for 20 years vs. those that haven't. There is no comparison. Muscle is metabolic currency and the best correlate to quality of life in longevity, which is more important than longevity itself. This is like looking at a math problem and seeing that answer is the obviously wrong, but saying, "Well, they showed their work..." The work is wrong. I could see 10 years ago that the older people with the most vitality we're on hormone replacement therapy, women included, and basic observation over time confirmed that if I wanted to model after them I should live an active lifestyle (exercise endurance, strength with full ranges of motion/high mobility demands) supported by exogenous hormones (when natural levels decline enough). It's bonkers to deny the obvious vitality difference in these cohorts. Also, the "little known side effects" mentioned are common knowledge in people on HRT and more easily managed than someone on a suboptimal diet. 1 Reply 5 replies @debj1356 @debj1356 1 year ago I can't believe you completely left out HRT and menopause. 12 Reply @AJ-xi4hb @AJ-xi4hb 1 year ago whats the best place to buy nad and nmn Reply @vinniesikka6187 @vinniesikka6187 10 months ago His comments on trt and Hgh are somewhat ridiculous. He’s assuming people are abusing it vs using maintenance dosing. He’s not a dr. And it clearly shows as he has to read everything he’s saying. Reply @BirdTurdMemes @BirdTurdMemes 1 year ago Good podcast, you should redo your animated intro, the music is a bit too loud for a portion of it. Reply @philipgeorgiev @philipgeorgiev 1 year ago Kick ass podcasst 1 Reply @piotrsitek818 @piotrsitek818 1 year ago this is great Reply @pamelawathi5461 @pamelawathi5461 1 year ago Can anyone on hrt/bhrt take NMN? Reply @PaulManningg @PaulManningg 1 year ago Hello Dr. Sinclair, do you have any opinions on creatine supplementation? 1 Reply 1 reply @madonnatolentino9817 @madonnatolentino9817 1 year ago glaucoma.. i hope therapy to reverse it be avail soon.. we r running out of time and I am super worried Reply @samanthalam5421 @samanthalam5421 1 year ago Can we rejuvenate ovaries? 1 Reply @halnineooo136 @halnineooo136 1 year ago Is it a stupid idea to save and freeze young blood for one's old days? Our blood when we're young holds a youthful balanced hormonal and immune components that may set the body back to healthier state. Is it sound? Thank you. 2 Reply 2 replies @benjamjo @benjamjo 1 year ago Does anyone know who provides Biological Age test in Australia? Thanks Reply @johnmartinsen7623 @johnmartinsen7623 9 months ago Why are you afraid to have a conversation with Dr Paul Saladino? He makes some good points that you clearly don't want to acknowledge. Upton Sinclair said it best..."It is difficult to get a man to understand something when his salary depends on his not understanding it." Reply @leonaowen9234 @leonaowen9234 1 year ago How do you get cells from an embryo? 1 Reply @josephsinha613 @josephsinha613 7 months ago Testosterone also hardens the arteries - allowing for much easier tears - and the T molecules are large and damage the kidneys over time. This plus clotting is why bodybuilders are dying. Reply 1 reply @yayangtapir4130 @yayangtapir4130 1 year ago Today both of you wearing indigo blue??!! .🤔....looking cool....😁 Thanks for another great episode....! Reply @cheekybastard99 @cheekybastard99 1 year ago Curious why he's misinforming people about the legal situation about peptides. Reply @garyhurstjr512 @garyhurstjr512 1 year ago Where can I buy Mots-C? And what brand? Reply @skizrock0722 @skizrock0722 1 year ago Does athletic greens break your fast? Reply @auroramarialopez @auroramarialopez 1 year ago (edited) And sorry another question which is the name of the chinese study / scientists that are looking to reverse senescent cell with exosome ? Or where I can read more about it ? Reply @shylaandrews4435 @shylaandrews4435 1 year ago Hi Dr… how can a diabetic fast what abt hypoglycaemia.. how to overcome that? Reply @youtubeiscruel3946 @youtubeiscruel3946 1 year ago "I've been taking athletic greens for a number of years now" Reply @standsure2639 @standsure2639 1 year ago What about Selegiline? Reply @robsolo4024 @robsolo4024 3 months ago Do they think they could repair a optic nerve that was damaged during surgery like myself how can I continue to follow up on this being I am legally blind from my pituitary tumor being removed Reply @concernedcitizen780 @concernedcitizen780 8 months ago Medical school rarely has a nutritional course. Reply @dianginsberg942 @dianginsberg942 1 year ago Yes. That is why testosterone pellets hurt women!! Appropriate well monitored menopause bio identical hormone replacement is the key. Reply @joeanarumo616 @joeanarumo616 1 year ago Thank you once again 2 Reply @lakkmentor9333 @lakkmentor9333 1 year ago Excellent Reply @KotobukiGirl @KotobukiGirl 1 year ago What do Dorian, I mean David Sinclair and Matthew LaPlante think of Joe Dispenza's supplements? Reply @MrMike44v @MrMike44v 1 year ago The only thing i dislike about this podcast is way too many ad breaks Reply @BioHealLabs @BioHealLabs 9 months ago Touching on stem cells. What is your opinion on urine therapy. Do you see any benefits? Reply 1 reply @aiculsunlight9713 @aiculsunlight9713 1 year ago I have hypothyroidism & my thyroid is shrinking . Can you please make me a new one ? I really dislike the fact that I have to take thyroid’s hormone for life Thanks Reply @thetraveler79 @thetraveler79 6 months ago Do you know about a peptide named Epitalon? Reply @bobbyboyce6174 @bobbyboyce6174 1 year ago Ok.. so fasting promotes and raises testosterone and hgh.. so is fasting not good for longevity? Reply @BumpAhead @BumpAhead 1 year ago Their concerns sound like the same THEY should of said regarding COVID vaccine. The sad irony. Reply @europizzacafefountainhills9206 @europizzacafefountainhills9206 1 year ago You didn’t address the fetal stem cells. That’s very different from what you’re saying Reply @barbaralanzante5619 @barbaralanzante5619 1 year ago I was hoping you Would have spoke of bio identical hormone therapy? 1 Reply @thecirclenetwork4443 @thecirclenetwork4443 1 year ago Plz use these secrets for ur face too Reply @colinweir3203 @colinweir3203 1 year ago What about ESTROGEN blockers 1 Reply @cristianyrabelo2835 @cristianyrabelo2835 1 year ago Is facial threads safe? Reply @alexanderohanlon8825 @alexanderohanlon8825 1 year ago And this has been know for decade's, hence why kids go missing and turn up drained is big buisness. 1 Reply @houssem_elfhaiel @houssem_elfhaiel 1 month ago thank you Reply @JoseMiguel-or1lb @JoseMiguel-or1lb 10 months ago Can you check MFIII products Of Switzerland for antiaging Reply @nicolepazos1407 @nicolepazos1407 1 year ago (edited) Athletic greens putting in werk Reply @AnkushSharma-zv5hv @AnkushSharma-zv5hv 1 year ago awsm awsm..once more David Sinclair Reply @MinMin-kv3rv @MinMin-kv3rv 1 year ago Please someone answer - I find info, that sauna boost Growth hormone in high levels. Even athletes use sauna to grow muscle. But also everyone here is telling sauna is great for longivity. So frequent sauna = growth hormone - good or bad or what? 1 Reply @willfrank961 @willfrank961 1 year ago Don't google Teratoma!! Stuff of nightmares 37:13 1 Reply @dystopiaseven @dystopiaseven 1 year ago Great 🔵⚪🗿👍 1 Reply @supportteam7783 @supportteam7783 1 year ago David do you take any of these things you discuss personally? You do look awfully young. Reply @HouseJawn @HouseJawn 6 months ago Hard to watch Sinclair, since his company got NMN supplement banned 1 Reply @raffaelloinigo6436 @raffaelloinigo6436 1 year ago COOL !!!! Reply @luigiciotola91 @luigiciotola91 1 year ago BPC-157 not BP 🤣 Reply @theshadow8008 @theshadow8008 1 year ago Well promoting is selling! Reply @michelles2299 @michelles2299 1 year ago Growth hormone dangerous if you don't know, what you are doing....... As for athletic greens OK if you are rich have you seen the cost of that stuff 1 Reply @CodyRay @CodyRay 1 year ago David I just need to know how you have no gray hair? Why and how ?!?! 1 Reply 1 reply @wmp3346 @wmp3346 1 year ago HGH - increase while fasting? Reply @pbalerig @pbalerig 1 year ago Inside track is only 20%? Not 25% off?? Reply @taylorleecc4833 @taylorleecc4833 5 months ago Pretty cool Reply @starrovers13 @starrovers13 7 months ago Pension funds be like: the hack r u guys doing to us? Reply @jamesfrith9869 @jamesfrith9869 1 year ago For the Alg boost Reply @Coatch-monir @Coatch-monir 1 year ago Thanks Reply @ayoubforreg5801 @ayoubforreg5801 1 year ago You both lovely (: Reply @PaulManningg @PaulManningg 1 year ago Let’s go! Reply @JanaLeeME @JanaLeeME 1 year ago Bonjour from Switzerland 🇨🇭! Je suis prête 😁 1 Reply @MrAcortesm @MrAcortesm 1 year ago David you look trippy when your reading. Reply @SM-ol9nb @SM-ol9nb 2 months ago Why would that wall have so many steps in it Reply @patrick815 @patrick815 1 year ago You must ask why these things are banned? Hint $ Reply @kans754 @kans754 1 year ago Fashion police says...loose the hat. Reply @frankiecal3186 @frankiecal3186 1 year ago Joe Rogan Hyperventilating.😵😫😩 1 Reply @PetersonChevy @PetersonChevy 1 year ago Too many commercials Reply @wmp3346 @wmp3346 1 year ago Why do you need a doctor? Reply @pb25193 @pb25193 3 months ago Don't Google search teratoma Reply @pinkberrydigital2237 @pinkberrydigital2237 1 year ago And what about women’s hormones?! I love you guys buttt 🙄🙄🙄 2 Reply @RENOWN55CHARGE @RENOWN55CHARGE 1 year ago 😩 These cavewomen though 🥵 Reply @cholakicha @cholakicha 1 year ago (edited) 51:30 Reply @robertmendez4990 @robertmendez4990 1 year ago Who wants to live forever. Postponing the inevitable Reply @RunToTheHills999 @RunToTheHills999 1 year ago Forta nemuritorii Reply @audiosmarts675 @audiosmarts675 1 year ago 18:11 Reply @ellaborelli2355 @ellaborelli2355 8 months ago 21:24 Reply @ajl8615 @ajl8615 1 year ago Can Co-host Matthew please don't hold a pan or even finger pointing to the speaker? This wasn't once, this occurs in every presentation. Its so distracted to viewers and also irrespectful to your host, thanks. Reply @Eonwe @Eonwe 1 year ago Unix live longer. Dump Windows. 1 Reply @yvanaj1 @yvanaj1 8 months ago too many adds men!! Reply 1 reply @a.c.3243 @a.c.3243 1 year ago Dr Sinclair ur looks is so pleasing… Reply @hansfrankfurter2903 @hansfrankfurter2903 1 year ago anyone notice David Sinclair has no lips? Reply @michelles2299 @michelles2299 1 year ago And you have botox I can tell 👍 1 Reply @jasonk2947 @jasonk2947 10 months ago Looks like you have low T Reply @bostaurus1 @bostaurus1 1 year ago Some one please count who speaks more, Matt or David? 1 Reply @khalidraza4839 @khalidraza4839 1 year ago Many thanks for that . I pray to Allah guide you to be Muslim. Prophet Noah did live over nine hundred year.(950). 4 Reply 2 replies @chickensandw1tch @chickensandw1tch 1 year ago (edited) 24:12 oohhh😎😎😎😎😎 34:00 lol Reply @smorgan125 @smorgan125 1 year ago Bitcoin 1 Reply @elenacaas150 @elenacaas150 1 year ago Aqaaaaa Reply @sandralee9849 @sandralee9849 1 year ago Try raising your camera angle so you are slightly looking up... you will tilt up your chin & forehead in an attractive way. Reply @josieb3238 @josieb3238 1 year ago I hope you live forever. Just don’t tell Trump about this science. 2 Reply @bostaurus1 @bostaurus1 1 year ago MATT just keeps talking 3 Reply @jadezee6316 @jadezee6316 1 year ago bad info about testosterone....jeez...where are the things people can do right now? all this guy does is talk about his lab his lab.....RESEARCH YOURSELF PEOPLE Reply @bostaurus1 @bostaurus1 1 year ago Matt is annoying. He speaks in an annoying way. Too many words. Trying to be funny. Speaks too slowly. Struggles to form sentences, searches for words very long even though his part is largely scripted! The dynamic is unnatural because it's scripted. It's the opposite of what a podcast should be like. 2 Reply 2 replies Skip navigation Lifespan w Dr. David Sinclair #6 9+ Avatar image 50:21 / 1:10:16 • Topical Treatments, Pills, and Dihydrotestosterone #6 Lifespan with Dr. David Sinclair The Science of Looking Younger, Longer | David Sinclair 713,593 views Feb 9, 2022 Podcast Episodes In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. The latest science behind various beautifying therapies is highlighted, including newer interventions like low-level laser therapy and platelet-rich plasma injections. #DavidSinclair #Longevity #SkinCare Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair Levels - https://levels.link/sinclair InsideTracker - https://insidetracker.com/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Lifespan podcast website: https://www.lifespanpodcast.com Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsincla... Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclai... Stay up to date with David's work to democratize biological age testing and insights: https://www.tallyhealth.com Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante Timestamps: 00:00:00 Launching Episode Six: Combating Cosmetic Aging & Improving Skin, Nails & Hair 00:02:54 Estrogen, Progesterone, and Menopause 00:09:51 Thanking the Sponsors 00:12:57 The Pinch Test, Epidermal Thinning, and Foot Ulcers 00:18:29 Skin and Biological Aging 00:23:19 Cellular Senescence, Ultraviolet Light, and Skin Aging 00:28:15 Collagen, Keratin, and Skin Health 00:33:38 A Quick Aside about Nails 00:34:45 Autophagy and Retinoids 00:36:57 Resveratrol, NAD Boosters, and Hyaluronic Acid 00:41:44 Botox, Skin Peels, and Microneedling 00:43:28 No Duh Stuff: Sun Damage, Smoking, Alcohol, and Bad Food 00:45:42 Hair Loss and Hair Graying 00:49:45 Topical Treatments, Pills, and Dihydrotestosterone 00:55:19 Frickin Laser Beams: Low-level Laser Therapy 00:57:59 Platelet-rich Plasma (PRP) Injections 01:00:11 Hair Aging, Stress, and Gray Hair Reversal 01:06:11 Targeting Aging Upstream 01:07:37 Today’s Takeaways 01:09:25 Subscription and Support Options Links: Human faces and mortality predictions: https://bit.ly/3rA0tgd Biological age prediction in human skin: https://bit.ly/3LdDZcO Senescent cells and lifespan in mice: https://go.nature.com/3HFO9Rh Nail growth and aging: https://bit.ly/34tnSYb Autophagy is a major regulator of aging: https://bit.ly/3uHh2Jr Hyaluronan and cancer resistance: https://go.nature.com/3HHoyHK Topical tretinoin and hair growth: https://bit.ly/3GCF0rl Dihydrotestosterone levels correlate with mortality: https://bit.ly/3GBFFJJ Eunuchs are especially long-lived: https://bit.ly/3ukL1GU Human hair greying is linked to life stress: https://bit.ly/3J5adVU Grey hair reversal in mice: https://bit.ly/3Li9F0J Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. Chapters View all Explore the podcast 8 episodes Podcast Episodes David Sinclair Podcasts David Sinclair 299K subscribers Videos About 1,489 Comments rongmaw lin Add a comment... @audiosmarts675 @audiosmarts675 1 year ago 28:22 Keratin & Collagen 34:50 Retinol and Retinoids 55:30 Low level laser therapy 58:15 Platelet rich plasma Gdf15 - Hair growth gene Tretinoin - Medication used to treat acne and sun-damaged skin 325 Reply 16 replies @FortniteKingClips @FortniteKingClips 1 year ago David inspired me to go to college to study molecular biology and aim for a career in fighting aging because I heard of him from the podcast he did with Joe Rogan in 2019. Thanks David! 780 Reply 50 replies @keira_iam4325 @keira_iam4325 1 year ago People often tell me that I don't look my "age" (in my 50's). I pay attention to eating (organic, mostly vegetables) , exercise regularly, don't drink alcohol, don't smoke, take supplements and use organic skincare products. David Sinclair speaks volumes of truth for anti-aging in this video and appreciate his scientific logic. 48 Reply 5 replies @traceyleigh1111 @traceyleigh1111 1 year ago I love this podcast. I am almost 53 but feel 33. And apparently look more like 43. Vegetarian, yoga and meditation has been good so far but this is amazing information. I was a late parent. To know I have to power to live long enough to see grand kids grow up is amazing. Thank you both for all that you do. 🙏 And I love the humour. 🖖 😆 Aussie Gratitude being sent your way 🇭🇲 85 Reply 8 replies @siamsiraji3169 @siamsiraji3169 1 year ago (edited) Dr Sinclair has been an inspiration for me. I have heard of him back in 2018 for the first time, since then been following all of his work. Now, this year I will be graduating from the dept. of Biochemistry and Biotechnology. Currently, I am working on one of the sirtuins genes. All because of Dr Sinclair. You made this young boy dream big. I just turned 23 this year. Haha.. and I have decided to pursue this longevity field. Thank you wholeheartedly, Dr Siclair. 207 Reply 9 replies @drkaushikt6926 @drkaushikt6926 1 year ago As a doctor, this is one of the very few podcasts I genuinely look forward to 153 Reply 13 replies @daveoatway6126 @daveoatway6126 1 year ago Great show. I have been using 1-Skin for a year and have noticed a difference in my skin. At 77 years old, my Pinch Test is very quick. I started taking NMN 3 years ago and noticed my hair getting brown again. This is increasing. Now I take 2 gm of NMN most days (i figure I am older and need all the help I can get) and walk 5-10 miles almost every day, with some HIIT. I'd be very interested in an update on Dr. Sinclair's father's journey. These shows are excellent - much better than many interviews with often clueless interviewers. 66 Reply 15 replies @donahileti9282 @donahileti9282 1 year ago Thank you for your very interesting podcasts. I was delighted to hear that this episode will be on HRT and womens ageing. Sadly male boldness took central stage. Please please please present an episode dedicated to menopause. Most doctors are not trained in menopause and the whole world acts as though it does not exist… 468 Reply 95 replies @xelaklement3367 @xelaklement3367 1 year ago Thank you SO much for these podcasts. I look forward to them each week! You manage to be factual and informative while still keeping it interesting and even funny (had to laugh quite a few times) I was also wondering if anyone knew if these sponsors are also available in Europe or if there's something similar available on the old continent? 15 Reply @johncarpenter8459 @johncarpenter8459 1 year ago Dear Dr. Sinclair and Mr LaPlante. First, thank you very much producing the Lifespan podcast. Second, I greatly encourage you to continue the show. The content is intellectually invigorating and practical. It is also hopeful. During a period marked by constant undesirable exogenous shocks, you have offered ways by which we can influence the trajectory of our personal health. I eagerly await season two. Best regards and thank you again, John 5 Reply @DocJaeBass @DocJaeBass 1 year ago Another hugely exciting podcast. I've turned off my movie channels and am rewatching this entire series and taking notes for my evening entertainment and education.Thank you. 7 Reply @marialand8655 @marialand8655 1 year ago Thank you for mentioning microneedling. I work with a similar technique with tattooing equipment to restructure scar tissue. The pain really depends on the area, depth and in women sometimes depending on what part of their menstrual circle they're at their pain threshold. 32 Reply 2 replies @PandaA-cv3mm @PandaA-cv3mm 1 year ago Thanks for this. My mom has used retin-a since she was about 25. She is over 70 now. No skin cancer or other crap…. Her skin rocks!Very incredible info. Lots of love ❤️ 43 Reply 3 replies @mr.roni0570 @mr.roni0570 1 year ago Wow. It's becoming one of my favorite podcast series. I'm not gonna miss anyone. Keep up the good work and keep up educating us. Take love. 13 Reply @ErickOberholtzer @ErickOberholtzer 1 year ago Thanks for the great content! I've read the book, but every podcast episode I take at least a few more little tidbits of new knowledge with me. 7 Reply @litildiva @litildiva 1 year ago all the knowledge and health benefits aside this is just top quality podcasting! would love to see you both having guests and taking this even farther <3 3 Reply @kat-ij4po @kat-ij4po 11 months ago I’ve just discovered this channel and Dr. Sinclair- he is fantastic. As a woman about the same age as David, this episode is of intense interest to me, but it covers a LOT of ground in a very short span and I’m hoping there are subsequent podcasts that go into a lot more detail. Not sure what is being recommended here in terms of hormone replacement for post menopausal women and confused as to other actionable takeaways. Hoping they slow all of this down and elaborate in subsequent podcasts that I just haven’t listened to yet! From prior podcasts I’m really clear that NMM, Resveratrol, Quercetin are great to take in the morning with a bit of fat - I’m on it! 2 Reply @gloria6396 @gloria6396 1 year ago ITS REMARKABLE HOW DR SINCLAIR HAS STAYED SO POSITIVE AFTER ALL HE HAS GONE THROUGH TO ME THIS IS ONE OF HIS MOST HELPFUL MESSAGE 10 Reply 3 replies @ptyh27 @ptyh27 1 year ago (edited) Dr. Sinclair looks really young for someone who is 52! I was watching his interview with Lewis Howes and it was really inspiring! I feel like it's something to do with our hormone change that age us as we get older 9 Reply @zvezdacolman345 @zvezdacolman345 1 year ago Thank you David! Addicted to your podcasts. So informative, educational, practical, interesting, exciting. And super helpful! And lots of fun as well. Just great stuff! 2 Reply 1 reply @JuliaRawsome @JuliaRawsome 1 year ago Looking forward to this podcast 😊 I‘m on a plantbased diet since over 10 years (including a high amount of raw foods on a daily base). I noticed that my body sticks to to the same weight for years. I rarely feel tired/sluggish during the day and my hair is growing better at 40 compared to my 20s. Also I eat within a 6-4 hour window. Just be your own project and see what works for you 67 Reply 14 replies @michaelt2397 @michaelt2397 1 year ago This has been a fascinating program. During the pandemic, I began to think about my general health and covid related comorbidities. This has slowly evolved into an interest in aging. I found this video to be very enlightening and slowly moving me along a track of looking at the aging process. I look forward to learning more in a rational and scientific way. Well done guys. LOL ... but an additional decade of life by adopting a eunuch lifestyle really cracked me up. Sorry, not for me. Reply @meloniedodaro2030 @meloniedodaro2030 3 months ago Fantastic episode. I’m going to watch all of the others you have here on your channel. Question: Have you stopped posting new episodes or will you be sharing more again in the future? Thank you! 1 Reply @kayas.1782 @kayas.1782 1 year ago Fascinating episode as always, guys! I was wondering if there’s any information regarding these ‘plant stem cell serums’ that I’ve noticed popping up in the cosmetics sections? Any validity in those, and if yes, what would be the science behind them? 22 Reply @bestrongandloveyourself2370 @bestrongandloveyourself2370 1 year ago I keep pinching my hand now 😄 Thank you for this very interesting and useful episode! 🥰🥰🥰 I will try to be more careful with my Tretinoin treatment, I didn’t know that in a long run it might have negative effects. I love your podcast!!! 💖💖💖 9 Reply @katiemiller2803 @katiemiller2803 1 year ago Thank you for doing this podcast! Best one out there! Thank you for addressing women. We get left out a lot in the longevity podcasts and research. 20 Reply 1 reply @diman585 @diman585 1 year ago Very insightful and interesting discussion. I am curious what percentage of your lifespan you can actually control with medications, diet and physical activity. For example, my grandpa is 94 right now, smoked in his 40’s then had a heart attack and quit per doctors reccomendation. He literally ate all the things that are known to humans as bad: sugar, salt, fat, etc. Granted, all of his arteries are clogged now and he’s not feeling great, but at 94?! So one thing that is very apparent throughout his life is that he was always on the move, constantly moving, walking, and rarely sitting. He often laughs when I check nutrition labels for cholesterol or sodium, saying exactly that: I enjoyed my life to the fullest with no limitations, so why restrict yourself now when you don’t know if you are going to wake up tomorrow? 🤷‍♂️ Can’t argue with that logic... 3 Reply @nickyo56 @nickyo56 1 year ago My new favorite podcast! Hope you keep it going after 8 episodes. 85 Reply @irenhollo662 @irenhollo662 1 year ago Dr. Sinclair, as a Hungarian admire your work! A proud Mother of a Harvard Student! Your podcaste is enjoyable... and easy to understand! Please keep it up! Thank you for your work! 11 Reply @stylebase @stylebase 1 year ago Thank you dr Sinclair on giving us your thoughts about HRT. It is always a pleasure to see extraordinary professionals who consider questions of their audience :) 7 Reply 1 reply @ashleywessel780 @ashleywessel780 1 year ago Your personalities compliment and play off each other very nicely. Great conversation and info, thank you guys 4 Reply @evaeva-du2kg @evaeva-du2kg 1 year ago Thank you so much for giving us so precious information! I’d like to ask about hair loss. It happened to loose most of my hair volume due to chemotherapy for breast cancer. I was given actually taxotere that proved to be quite toxic for my hair follicles. Is there any treatment or any hope of treatment according to breakthrough science or is it considered to be the same as genetic alopecia? 2 Reply @cecipalacios1007 @cecipalacios1007 1 year ago As always a great conversation! Since I do not use gloves when I am around my kitchen I thought that doing the skin fold on my hands would not be a good indicator so I did it on my foot and the difference is day and night. This considering that Skin’s thickness is so much alike.. 7 Reply @taismonteiro374 @taismonteiro374 1 year ago Best podcast so far! Thank you so much, Dr. David Sinclair! 11 Reply @crazyfarmgirl606 @crazyfarmgirl606 1 year ago I am thankful for your podcast i am trying to soak up all the health and antiaging information i can. So that i can age well, both physically and mentally. I want to be an old person who can take care of themselves and have a full active life not requiring aid from others. 25 Reply @adbc8737 @adbc8737 1 year ago You are helping so many people improve their health! Thank You! 🌀💚🌀 24 Reply @claudettesechler149 @claudettesechler149 1 year ago Absolutely great! Loved learning about the product knowledge and thanks for breaking it all down! 6 Reply @katherandefy @katherandefy 1 year ago David and Matthew are so generous with their time. Live long and prosper, guys. We’re listening and learning. 1 Reply 2 replies @kapa0224 @kapa0224 1 year ago LOVE!!!!!!!! your podcasts! Thank you so much please keep making them. I listen many times and tell friends who love this content too. Heather 3 Reply @EMB-tl6mi @EMB-tl6mi 1 year ago Thank you for addressing this for women. I'm in estrogen, testosterone and progesterone and I feel great, lost some body fat and my mood improved drastically; but this is something my MD or OBGYN don't want to treat. I'm doing it outside my network and it's very expensive. 56 Reply 25 replies @AboodCohen @AboodCohen 1 year ago So glad I found this podcast early in life, very thankful for both of you! 33 Reply @pinkberrydigital2237 @pinkberrydigital2237 1 year ago Hey! I was one of the females that commented on your last video about leaving us out. I wanted to say thank you for addressing some of the issues surrounding female hormones and menopause. 😌 You guys are awesome 👏 👏👏👏 94 Reply 3 replies @eaglenebula2172 @eaglenebula2172 4 months ago (edited) It's insane how the living body is complex and how scientists understood so much about it despite our brains initially not meant for this kind of stuff. Reply @SebastianNiemann @SebastianNiemann 1 year ago All episodes are for me one of the best podcasts ever made. Thanks for all the amazing work! 5 Reply 1 reply @levondarratt787 @levondarratt787 1 year ago Matthew is amazing! The intelligence of questions, and follow-up points is incredible!!! 4 Reply @isabel1149 @isabel1149 1 year ago Gracias Dr. por toda la información que nos comparte. Sería genial que también los vídeos sean traducidos al español. 2 Reply @mariachristinewebsitesonli3680 @mariachristinewebsitesonli3680 1 year ago Great Podcast! Just a question: Doesn`t hair loss also have to do with acidosis/ hyperacidity? In that case it would have a lot to do with what you eat or drink... 3 Reply @aaliyahlee1265 @aaliyahlee1265 1 year ago Thanks to Dr. Sinclair. I've always loved his videos. It's through him I learned about the benefits that NMN provides. Because with age comes with health issues. When you reach about 60, you often need major medical attention. But ever since I'm taking the vitruvin NMN supplement, it changed my life and the way I live everyday! 3 Reply 2 replies @Mexicolivingeveryminute @Mexicolivingeveryminute 1 year ago (edited) Great video. Thank you so much. The thing I find confusing is the idea that thin and smaller people live longer. But, I’ve had both my Primary doctor and my Gyno tell me at 60, that I was getting too thin, and to “be careful”. They said that if you get really sick, being too thin can be bad, because your body has no fat stores to draw from, and also the increase of osteoporosis in older thin women. I’m 60, and thin, but not underweight thin. 6 Reply 2 replies @rachelstark8002 @rachelstark8002 1 year ago This is exactly what I am telling to my family, especially to my husband who just recently take Vitruvin NMN with me. We imagined how amazing it will be to still hug and kiss our lovely grandchildren when we reach 90. So grateful to this supplement! Thanks to Dr. Sinclair who adds more years to our lives! 2 Reply 1 reply @paulatomlins1852 @paulatomlins1852 1 day ago I am 64 and have been faithfully wearing sunscreen since about 26 years old. However, I've never really understood why something as natural as the sun should cause so much damage to our skin, including skin cancer. Reply @crh251 @crh251 1 year ago As a woman, I started looking into bioidenticals as a preventative measure once I went through menopause. My blood pressure had elevated, but the hormones brought it back down again. Supposedly one out of two women in post menopause have a heart attack. That’s a scary statistic. 4 Reply 2 replies @musicalfringe @musicalfringe 1 year ago The trouble with tacrolimus is that it seems to be cardiotoxic in chronic use. My father, a liver-transplant patient, was on it for 5 years before switching to a different immunosuppression regimen (both very low doses), and now suffers from atrial fibrillation. It seems that about 5 years is the point where cardiotoxicity starts manifesting. Bret Weinstein's "all our lab mice are broken" hypothesis predicts a silent epidemic of cardiotoxicity in our drugs, and I'd imagine this is something to take into account with all these rejuvenating drugs. Reply @MichaelVelvet @MichaelVelvet 1 year ago Wish there was a “Love” button. I love this show and I love your work Dr. Sinclair. Much respect and love for this content. 19 Reply 2 replies @marleerobertson5928 @marleerobertson5928 1 year ago Dr. David, thank you for your work and willingness to share! I’m sure this doesn’t come with a quick, easy answer - do you have research pertaining to people dealing with issues like histamine intolerance/mast cell activation syndrome? I’ve wondered if some of the products you talk about would trigger reactions in these folks. Thanks again! 4 Reply @oliviamiller8187 @oliviamiller8187 1 year ago NMN demonstrated multiple benefits such as fighting muscle degeneration in elderly men and women, aerobic capability, and increasing endurance. The results may vary from person to person. Personally, it has been my 3rd month of taking NMN by vitruvin, that's 500mg, and I love how it worked impressively. I wish many people would give a shot in taking NMN and start living a happy, balanced, and healthy life as they age! 5 Reply 2 replies @duckslave @duckslave 1 year ago I’ve emailed pictures to David at his Harvard lab of the re-birth of hair on my formerly mostly-bald head - and it’s dark, not gray hair. This rather amazing phenomenon occurred within two months of taking the same supplements as David, and has only become more evident over time. At age 75 (Epigenetic age via Horvath clock is 60), having my hair back is a great thrill! I’m surprised you didn’t discuss this sort of thing since the color-changing and re-growth was observed in the Stanford thymus regeneration trial using growth hormone, DHEA and Metformin. Keep up the great work!! 2 Reply 11 replies @lylan8737 @lylan8737 1 year ago Thank you Dr David. i’m your biggest fan and i loved the life spam book that i reread it every once a while. I found your book calming and your voice is also calming. I love learning such great things from you and the best thing is that ur voice is healing 2 Reply @raulrodriquez3404 @raulrodriquez3404 1 year ago Thank you David for all the great work you are doing for mankind. God bless you and the work you do. 🙏🏽 I would like to know if there is anything that can be done to reverse and cure Vitiligo? I’ve had it for about 15 years, but so far have not found anyone dealing with or trying to correct the underlying cause of this disease. All the Best ! 1 Reply 1 reply @jerumgamboa2717 @jerumgamboa2717 9 months ago I have a son have a glaucoma on the left eye in his early age and when he turned 10yrs old and its affect the other eyes and i am still hopeful he can get back his sight with the science and technology today with expert same as you. I am seeing a light of the tunnel when i saw your podcast and i am hopeful you can help me Dr. David. 3 Reply @simonfoo8684 @simonfoo8684 1 year ago Thank you for sharing the sciences behind aging and possible pathways to reverse or slow down the process. 2 Reply @kimdorcy5150 @kimdorcy5150 5 months ago I think the right timing for HRT is key. I am 45 but have been on HRT for about a year. The results I have experienced are lowered blood pressure , change in appetite and food cravings to where I dont crave sugary snacks and imnot hungry through the day if I eat healthy meals. ThT said I have changed the way I eat and excluded manufactured oils fast food , and cut as much added sugar as possible. I've increased intake of whole foods and I never was one to eat fast food so that was easy. I cut out sodas years ago. If the outside is a reflection of the inside then things are going in the right direction. I also use oneskin daily with sunscreen. 365 days a year I use sunscreen. My dad has had skin cancer removed 2 times. he grew up in a time where they just didn't wear sunscreen like we do now. Reply @strictlyprivate6914 @strictlyprivate6914 1 year ago Prof. Sinclair looks younger now than he did five years ago by well over 10 years. Fantastic!!! Resveratrol and NMN outstanding results 5 Reply @kittymurrah7400 @kittymurrah7400 1 year ago Dr Sinclair, I have been following you for about 3 years. Your knowledge is so impressive and hopeful. I have learned so much!!! Thank you 12 Reply 1 reply @inhocsignovinces8061 @inhocsignovinces8061 1 year ago Laser skin resurfacing, which wasn't mentioned, seems to be one of the best current anti-aging treatments out there, working both through hormesis (skin regrowth) and literally wiping out the below the surface senescent skin cells and cross-links (advanced glycation end products). 29 Reply 4 replies @yayangtapir4130 @yayangtapir4130 1 year ago It's huge one..!.. thank you for educating us on epidermal thinning....you guys are in a mission to change our age old beliefs and make all the folk lores about staying young like vampires minus blood sucking come true....🙏🙏 3 Reply 1 reply @NMNAntiAge @NMNAntiAge 1 year ago Great talk, thank you for your work as always! 2 Reply @juliak2591 @juliak2591 1 year ago I enjoyed this talk very much. Dr. Sinclair is clear and thorough. The interviewer is excellent as well. I had all my questions answered. Thank you! Reply @commonomics @commonomics 1 year ago PLEASE do an episode on fertility for both men and women. I’m suffering from recurrent miscarriages and I would love to have some literature interpreted into layman’s terms. 30 Reply 4 replies @tombro4867 @tombro4867 1 year ago Great series! What about sleep and longevity? I hear a lot of different things about sleep. As a triathlete and a person that has run some marathons what is too much exercise? I have cut back and now do shorter runs, bikes and swims as the longer courses training seems to have me pretty wiped out most of the time. 1 Reply @lauriegaudio4006 @lauriegaudio4006 1 year ago This sounds amazing. I know this is a great calming and healthy practice for the mind and body which is especially needed since COVID. 6 Reply @norelitu @norelitu 1 year ago David, can you talk a bit about the laser hair removal and its effects on skin aging? It sounds counterintuitive but maybe there is something in the medical literature I haven’t heard of. Thanks! Great series! 6 Reply @Glombidio @Glombidio 1 year ago Just watched this today! Very interesting! On the topic of grey hair, I wanted to let you know of an example that some medications have the effect of restoring hair color! My best friend's dad was in hospital receiving haemodialysis treatment for his kidneys 5-6 times a week. He was 78 years old and his hair before the treatment was grey all over! After a few months of treatment his hair had become brown, as it was when he was young! All of it! It was a shock to see him after a few months with brown hair! I don't know what the medication he was being treated with was but it sure worked well on his hair color!! :) Reply 1 reply @the_notorious_bas @the_notorious_bas 5 months ago (edited) Nice conversation! As for Finasteride, from what I understand, is that Dutasteride is even more effective. I quote: "The main difference between finasteride and dutasteride is that finasteride is selective for type II 5AR while dutasteride inhibits both type I and type II. Dutasteride not only blocks both types of receptors but also does so much more effectively. This may be a result of the much longer half-life of dutasteride compared to finasteride (~4 weeks vs. 6-8 hours respectively). Dutasteride has been shown to be 3 times more potent than finasteride at inhibiting type II 5AR and more than 100 times at inhibiting type I 5AR. Furthermore, oral dutasteride decreases serum DHT concentrations by up to 90% while finasteride only reduces DHT by 70%." Reply @Jay-dq5fw @Jay-dq5fw 1 year ago Great podcast! Thank you! I would love to see an episode on arthritis. 4 Reply 1 reply @jasontillery @jasontillery 1 year ago Love your videos. Is it possible to provide your personal list of supplements along with where to get them at the highest grade or processing standards? Thank you thank you 3 Reply @jewelleryaddict @jewelleryaddict 1 year ago Thank you for including help for specifics on women's aging. So hard to find relevant info on it usually we are passed by as most studies in past did not include women because of our "difficult" hormones as we are usually told. Even if that's the problem women have more chronic illnesses and take most of the drugs made leaving us to play Russian roulette with whatever drugs we are given hoping they will work the same in us as a man. So bravo for including women's specific problems in you talks. Reply @leather_bath @leather_bath 1 year ago I’m Australian, and naturally very pale. So set up for failure basically. But, I practiced sun avoidance and daily sunscreen since I was quite young. And then started retinol products in my early 20’s, moving onto tretinoin in my early 30’s. I’m 35, and still don’t have any fine lines. Which from what I understand, is pretty unusual. I don’t use tretinoin every night (maybe every other night), I mix it up with some nights using no actives, just cleanse and moisturiser, or using an AHA in place of tretinoin. And I always apply moisturiser on damp skin. 4 Reply 3 replies @plantbasedathleterealtor6145 @plantbasedathleterealtor6145 1 year ago I am grateful for all your podcasts 💫🙏🏻 1 Reply @sirt1353 @sirt1353 1 year ago Very intresting, I am specifically thinking about the hair regrowth subject. This made me start on my anti-age journey as a 28 year old active man. Currently I am taking NMN, Fisetin, Quercetin, Spermedin and Hyalronic acid in order to also get thicker hair and better skin. Not sure, but for some reason I still feel a lack of energy and a will to do things. I did a PRP treatment a few weeks ago, but experienced a lot of sudden hair loss, not sure if this comes from the "shock/trauma", and still very unsure if I am going to do the 2nd recommanded session etc. 3 Reply 6 replies @melissashare7543 @melissashare7543 1 year ago I enjoyed this podcast and am learning so much through all of your podcasts, so far. I have implemented a number of your longevity protocols and have added a few of my own. I was a little disappointed that you did not address age related bone loss and it’s effects on skin aging in this episode. I have started taking vitamin K2 and Nattokinase as part of my daily regimen. I would be interested if you thought that these could help reverse bone loss? I have heard that K2 helps to guide Calcium produced by Vitamin D3 to the bones instead of the bloodstream and would appreciate your thoughts on this, as well as any other protocols that you would recommend for bone loss. Thank You for sharing your knowledge! 15 Reply 3 replies @aiculsunlight9713 @aiculsunlight9713 1 year ago Thank you so much Dr. Sinclair and “lovely” co - host for sharing your knowledge. I have listened/watched/shared your podcast often. I just wanted to make sure I understood. If my nails are growing too fast … does it means that I am aging too fast, or the other way around ? Reply @weeniefred7166 @weeniefred7166 1 year ago (edited) I discovered this podcast last week and have been enjoying it very much. One issue I had with this episode was regarding the representation of Dr. Baroni's OneSkin topical cream. Because I trust Dr. Sinclair, I got excited about the product and almost purchased. Luckily, while at the website, I read the cited study literature. In it, Peptide 14 (the control/main active ingredient) was found to be significantly more effective than retinol - great news, right? The only issue was that the type of retinol tested was not disclosed, nor was the concentration. This was not disclosed anywhere in the results or the methods, which is unusual when doing a comparison study which presents graphical data. I found this to be very unprofessional and scientifically disappointing... And I wish that Dr. Sinclair would not have stated that the OneSkin product is as effective as Retin A (retinoic acid) when the literature itself only mentions an undisclosed concentration of retinol (a less effective precursor of retinoic acid). Anyway, great podcast, but keep your ears open and pay attention to misrepresentation of research! Reply @catsteinhilb2880 @catsteinhilb2880 1 year ago Thank you!! For finally addressing women’s hormones, particularly Menopause!!! 19 Reply @Plumpers @Plumpers 1 year ago Using my red/infrared laser light while I watch this on my head and face. It's really helped me with my brain fog left over from having COVID a year ago 11 Reply 2 replies @arwendriel19 @arwendriel19 7 months ago Thank you for this highly informative episode :D. Perhaps I missed it, does topical application of L-Ascorbic Acid improve the skin (collagen synthesis, uv protection, etc.)? Reply @Chris-ni2pc @Chris-ni2pc 1 year ago I was wondering for a while why some of my greys returned back to its regular colour, the explaination of it being stress induced and environmental makes a lot of sense 10 Reply 5 replies @heatherschramm @heatherschramm 1 year ago Thank you for addressing the role of female hormones on aging. 14 Reply 1 reply @rebeccacrawford602 @rebeccacrawford602 1 year ago I would love to know what kind of products Dr. Sinclair personally uses on his skin. And I was really hoping cellulite was going to be addressed in this episode. 33 Reply 17 replies @BadgerMilk69 @BadgerMilk69 1 year ago Never heard of the LLLT before, seems interesting. Diametrically related, I’m a huge fan of red light therapy in general. Improvements in hair, skin, nails, energy, sexual function, mental acuity/cognition and it has an effect for reduction in joint pain. Of course, it’s not an end all be all type of treatment but it’s easy and relaxing to use, can be extremely inexpensive, and effective. 1 Reply 3 replies @pinkberrydigital2237 @pinkberrydigital2237 1 year ago Regarding PRP, this is a very lovely treatment that can be done to rejuvenate the face as well, specifically when mixed with bio-stimulators like Sculptra aka Plasmasculpt ( shoutout to Dr. Rajani-also here on YouTube). But PRF is even better for hair, skin, and bodily rejuvenation. It’s also used in Dental surgeries. The Platelet rich Fibrin has a lot more growth factors and the results are so much better. I’ve had them both done locally. To get the Fibrin you simply spin the blood slower and for a shorter amount of time at the right angle. You then inject the fluid before it fully clots. Once you have a clot you can spread it across the face/scalp and micro needle it in. These treatments are A-MAZING for rejuvenation. 10 Reply @Windy888City @Windy888City 1 year ago I've often wondered about the connection between scar tissue/collagen overgrowth and normal skin regeneration 3 Reply @irandiaz2895 @irandiaz2895 11 months ago I always look forward to listening to his content. I would love to work with David Sinclair one day. 1 Reply @johny16G @johny16G 1 year ago Just found about you 3 days ago and saw everything on this channel! Can’t wait for more episodes to come. 24 Reply @ableinternational3611 @ableinternational3611 1 year ago (edited) As always packed with great info. Questions: 1. Are the topical cream such as Rogain and Retinol for men only or both? 2. About Hyaluronic Acid, is it effective to take it pill firms? 3. Couldn't find topical nicotinamide, but found nicotinic acid. The internet says nicotinic acid is niacin. Is it true? They do have topical nicotinamide? Which one is more effective? 4. Will it be helpful to take keratin pill for hair, nail and skin? Sorry for so many questions 2 Reply @Shasha8674 @Shasha8674 1 year ago I agree...find out good levels so you can copy them later, but my progesterone was low due to stress at my job and gluten. My levels were not perfect. Progesterone/Vit B12 helps the bones/myelin/thyroid/stress/immune system. Electrodermal tests/hair tests are great help. Genova tests are for hormones/allergies/nutrients/mitochondria. Ulcers/Diabetes/low thyroid/hair loss etc.. can be due to gluten. Gluten is in wheat/barley.rye...oats/corn/rice. Rice is low in gluten. Wild rice has no gluten....is a grass.. Ozone treatment can help clear up infections fast. Starch/sugar/low Mg may cause glycation wrinkles. Mg helps make insulin. Asian diet may help people heal and have a long happy/healthy life. 3 Reply @cmickie3296 @cmickie3296 1 year ago Fascinating. Thank you gentlemen, for sharing your experience with us. 3 Reply @Iza66 @Iza66 1 year ago Great episode, thank you. As I’m suffering alopecia universalis it would be great if there could be any advice about existence of a treatment. 4 Reply @rapamycinnews @rapamycinnews 1 year ago Thanks for the podcast. David mentioned that a few people are taking rapamycin working closely with doctors, but there are actually thousands of us using rapamycin with good results. Its now easy to get prescriptions and to purchase this low cost generic drug. 3 Reply 1 reply @ferdinandgoglia3634 @ferdinandgoglia3634 1 year ago I've never exercised in 50 years, and I've probably eaten less than 1kg of veggies in 4 decades. Started feeling a bit rough recently, so I am trying to improve my health starting this week, so wish me luck😁 4 Reply @tinacaruselle5949 @tinacaruselle5949 1 year ago Great information! I do have a question. If the body going through periods of stress can make hair grey, how does it improve longevity? 5 Reply 1 reply @cailllou25 @cailllou25 1 year ago I've been using tretinoin daily for the last 20 years, since I was in my early 30s. I'm 50 now and my skin looks better than it looked when I started it. I don't see any side effect or accelerate aging, at least not yet. 59 Reply 5 replies @meganwolfe2185 @meganwolfe2185 1 year ago Please do not shy away from talking about female concerns just because you aren't women. You don't have to have a uterus to understand the science of how they work! This approach runs the risk of leaving women in the dark. Please address our aging concerns equally. Thank you for the great info. I love your show! 14 Reply 1 reply @brettarogers144 @brettarogers144 7 months ago (edited) You're right about antioxidants. I covered this topic in my textbook. Thee polyphenols are stimulating anti-aging genes (ex. Sirtuins) to produce their benefits on the body - antioxidant properties are pretty insignificant. Reply @senseofwonder4734 @senseofwonder4734 1 year ago Thank you for these podacst videos! You are so amazingly generous to share this with the world. 2 Reply @maxjk1143 @maxjk1143 1 year ago Hello Prof. Sinclair, thanks for your Work and Curiosity in this field and that you share it with us! I have learned a lot by watching your Interviews and Podcasts and reading your Book. Do you know about any scientific Data about the Effectiveness/Harmfulness of Face Massage by Vibration regarding looking younger? Reply @dorothytaylor-dasilva7329 @dorothytaylor-dasilva7329 1 year ago Never heard of a skin pinch taking so long. At 67, mine is still less than 2 secs. Used this to assess hygration/dehydration. 5 Reply 3 replies @kellysober9352 @kellysober9352 1 year ago I have been following David’s work for about 2 yrs now. Thank you for addressing women. You do have women listening. It does seem like women get left out of the coversation, out of research and their health issues (like autoimmunity) don’t get money and attention. It does feel like wr are second class honestly. 37 Reply 1 reply @cherylsimon7619 @cherylsimon7619 1 year ago Thank you for this video! Curious if there's any data on negative effects on lifespan from Botox? You're the best! 4 Reply @Everythinggutter @Everythinggutter 1 year ago The key to visual aging is organ knowledge 🙌 3 Reply @MrVictorchase @MrVictorchase 1 year ago I think achieving rejuvenation of appearance, without faking it, demonstrates mastery of anti-aging. e.g. reversing greying of hair (without dyes and such). Reply @LianaBuzea @LianaBuzea 1 year ago I so hope we approach hair thinning alopecia in women. This one I've had since 18... It was my nightmare. No matter what I tried, it wouldn't work. Maybe there's something new here that works for me. 🙏 11 Reply 5 replies @delcamino1736 @delcamino1736 1 year ago I wish Huberman lab podcast was as funny as yours! Thank you so much! Both podcasts are life-changing for me! 6 Reply @danas6398 @danas6398 1 year ago Loved the detail here. There was one part that was left hanging tough, which is whether these smaller HA molecules actually penetrate the skin and have a positive effect. Is there any evidence that topical HA works? 2 Reply @__taO__PJM__ @__taO__PJM__ 1 year ago I would love to hear more about Psoriasis as this disease can affect a large part of your skin. And there’s no cure for it yet, but would love to know how to make it better… 2 Reply 2 replies @LATSRN @LATSRN 1 year ago David I’ve read that Pregnenolone is a precursor of DHEA is there a place for these two supplements to work synergistically? Can they help with all the little aches & pains of ageing (I don’t use nsaids as I think they cause too many liver problems) Love your talks & lectures here on YouTube 👏👍 Reply @yurienaito6019 @yurienaito6019 1 year ago Regarding hair growing longer in places like ear after certain age, I heard that it happens because the body 'forgets' about the growth and fall cycle. 5 Reply @lisengel2498 @lisengel2498 1 year ago Interesting talk - I am 78 - and for some time I started eating 90 % whole food plants with Greens, beans, onions, mushrooms, nuts, seeds, berries and what I have observed is that my nails are getting stronger and that they grow faster 😊🍀💚🎶 19 Reply 5 replies @sanchez911 @sanchez911 1 year ago Love these interviews so much! Gives me a lot of motivation to stay healthy. But does this form of diet is applicable to kids unter 5 as well? I mean, as I understood children should grow, so it would not be healthy to slow growth, right? Reply @thenighttimecook8377 @thenighttimecook8377 1 year ago I love this podcast and your book. Thank you. I know you do not promote products, and you have given some markers of how to choose a good supplement (like GMP stamp of approval). Can you provide any more information on how to choose quality products, topical and otherwise? 4 Reply 1 reply @simsammalinao1823 @simsammalinao1823 1 year ago Good conversation. Much thanks Dr. Sinclaire and Matthew. 3 Reply @GDName @GDName 1 year ago I love this format between the two of you. Reply @mystikrebel1321 @mystikrebel1321 1 year ago A very interesting and educational discussion totally worth the time 2 Reply @callofthedark @callofthedark 1 year ago (edited) Let’s Go… It’s time to upgrade, to elevate and to be better. 6th episode for the 6th week of 2022. What a way to begin a legendary start of my new year.. 🥰 10 Reply 1 reply @TheGlutes @TheGlutes 1 year ago (edited) Really enjoying this channel. Thx you for making science, data, etc more accessible to us lay folk. Let some of that gray show through tho, David. I promise you, it will enhance your appearance, your appeal hence ... thus your longevity ;-) 4 Reply @ca9878 @ca9878 1 year ago I'm glad they talk about menopause! So many women are going through this and all it's bad vicious side effect. Reply @OO-il7ro @OO-il7ro 1 year ago (edited) I appreciate this podcast. I tried Retin A and it gave me telogen effluvium. My hair started shedding like crazy and I even started to lose my eyelashes. I’be tested this twice and after about 3 months of trying it, the hair shedding started again. I’ve looked online and it seems I’m not the only one whom this happens to. Is there an alternative to retin a that u could use? Or do you know if the hair loss from retin a could be prevented somehow? 3 Reply 3 replies @enqumeskmekonnen2915 @enqumeskmekonnen2915 1 year ago Great information. But for those of us who don't prefer to use lab made products, if you have naturally occurring alternatives you can suggest to us that would be highly appreciated. Like for example i heard rosemary oil is as good as minoxidil. Reply @meravrosenberg2766 @meravrosenberg2766 1 year ago At last. I have been waiting to hearing you about this subject. Thank you. Looking forward for more episodes regarding women in general menopause and hormone replacement therapy. 2 Reply @ouakourrajae1238 @ouakourrajae1238 1 year ago Thank you Doctor l want to share with you i ve been very sick for years but since i ve been aplying some essential oils on my skin it helps me a lot the pain is gone my skin is better and my hair becomes darker. 3 Reply @lchpillmore @lchpillmore 1 year ago In keeping with your discussion of taking baseline readings of hormone levels before peri menopause begins, I’d like to suggest that a baseline DEXA scan be performed routinely. There is evidence that much of bone loss may occur during pregnancy, as the fetus demands calcium from the mother. It would be good to know how much bone is lost before the decline in estrogen really begins and to address it prophylactically.. Reply @Fajita.tamale @Fajita.tamale 1 year ago Couple spoons of yogurt, half a cup protein and BCAAs, half coconut and filtered water and NMN resveratrol = Uber health. The BCAAs are already crazy for exercise, just kills soreness immediately, the flavor combos pretty good too. I tried without the yogurt and the resv. stuck to the sides, even with olive oil in the protein the resv. stuck to the side. Reply @heracles89 @heracles89 1 year ago I’m actually considering changing my career as I didn’t realise ageing was something science and engineering could solve - I want to part of the effort to supercharge the solution 6 Reply 2 replies @19Jetta @19Jetta 1 year ago I have been on NMN and resveratrol for a little over two weeks now...and it is working. I track my blood pressure and blood sugar most days. Both have stayed stubbornly high over the last few years, probably mostly due to the fact that I have gained weight in the last few years. I am working on the weight but so far I haven't lost...but my blood pressure and sugar are both down. This morning my bp was 118/83 and blood sugar was 98. This is the lowest these markers have been...years. I am excited to see my progress as I lose weight and continue to improve my diet. Thank you Dr Sinclair! 14 Reply 5 replies @amfs @amfs 1 year ago Thanks a lot for sharing your knowledge with us simple people💝 Reply @cristinalusardi2857 @cristinalusardi2857 1 year ago PUEDES PONER TAMBIÉN SUBTÍTULOS EN ESPAÑOL, PARA MILES DE HISPANOS QUE QUIEREN ENTENDER TODO LO QUE DICES. 4 Reply @stephiegetsit @stephiegetsit 1 year ago (edited) I use collagen and alpha hydroxy acid supplement form ,nuvage red light and skin lifting device, love it, my Malaysma basically all gone, AOR estrogen adapt (1/3 the recommended dose full and half does was to strong ) and plant based progesterone cream and a gall bladder support . 54, zero hot flashing or menopause issues now. Although no menstruation and happy that's not showing up. Weight lifting clean diet. And I have zero medication. 2 Reply @angellaonase @angellaonase 1 year ago I get a few gray hair every summer and they darken when I get away from direct sun, year after year. The whole of the individual hair whitens in a week of sun exposure and two months after the root is dark again while the rest of the hair remains white. Reply @LisaAnnRay @LisaAnnRay 1 year ago I do PRP on my face and it’s been a game changer. I use it in conjunction with radio frequency microneedling. Reply @meglovestocook7679 @meglovestocook7679 1 year ago Hi David, Just discovered your channel and I am already a fan after watching a couple of your videos. I have been intermittent fasting for years but have gotten mixed advice on what is truly considered fasting? Some say anything under 50 calories will keep your body in a ketone state as other have said you can’t even have coffee because your stomach has to digest the antioxidants and enzymes. Can you set the record straight for many of us fasters out there? Much appreciated thank you! 1 Reply 1 reply @Marta_is_here @Marta_is_here 1 year ago I’m female, will be 59 in April…I’m not done watching the video yet, but I just did the skin test. Popped back down pretty fast, like 1 second. I’m happy with that. I also had my one and only baby one month shy of my 41st birthday. Natural, no IVF or anything at all. He’s off to college this fall. I’ve lived my life to be 105… glad I found you a few years back!! I am trying to do what fits in my budget, supplements and such. But I must say, besides having Familial hypercholesterolaemia, I think my genes are pretty good. 👍 3 Reply 2 replies @bonnieoliver219 @bonnieoliver219 1 year ago An intriguing series. So informative. As a scientist I appreciate your willingness to share your research to the public at large. Grazie. Reply @Julia-qm7xg @Julia-qm7xg 1 year ago Excellent information! Thank you for this podcast! 3 Reply @brookejaeger3815 @brookejaeger3815 1 year ago Loving the podcast! I am 51 and my skin snapped back immediately ! 4 Reply 1 reply @user-uw7gb9lc7e @user-uw7gb9lc7e 1 year ago The science of UV damage to DNA really should be taught to schoolchildren. I know it would have saved me from many a sunburn as a teenager. I'd also love to see inside tracker expand to Australia! 1 Reply @KirstiCheetahh @KirstiCheetahh 7 months ago I love my menopause, no symptoms, does not feel like aging! I love having no more periods! I think I live it well because I was looking forward to it, positivity is powerful. Keto, IF and sports help too. Vitamin D3 and K2 and sports help to avoid osteoporosis and CVD. No need for unnatural hormone replacement therapies! Reply @pinkqueenscookie @pinkqueenscookie 1 year ago I’m so excited, I hope soon that the majority of women can safely have kids in their mid 40’s and 50’s. I think the social impact would be crazy but also for health. Reply @MariaBure @MariaBure 1 year ago Omg cosmetic aging is sooo important 😜 I couldn't be waiting more for this one! 12 Reply @rumnas185 @rumnas185 1 year ago This is my favorite channel on YouTube. I’m so thankful for your videos! 4 Reply @sunshinecitypersonaltraini7228 @sunshinecitypersonaltraini7228 1 year ago Great stuff! I am really enjoying these podcasts Reply @TheblondJane25 @TheblondJane25 1 year ago Love David Sinclair explanation, the facts, his voice and appearance! 3 Reply 2 replies @delphinekirkland1757 @delphinekirkland1757 10 months ago (edited) My hand pinch test confirms my slow level of aging from using fasting protocols for 44 years with super-nutrition is effective. I'm 62 and my skin flexes back in one second! I've been very active and I really enjoy amazingly healthy diet. Genetics helps. I seldom tire and never get sick. 1 Reply @sunshineh1039 @sunshineh1039 1 year ago Thanks for the awesome sharing! Dr. Sinclair, have you studied on dandruffs? Babies don’t have that but many adults do. 3 Reply @sharigordon6312 @sharigordon6312 8 months ago Very interesting and informative. Thank you! Reply @Eva-jc8sx @Eva-jc8sx 1 year ago (edited) " The Ordinary " is a cosmetic skin care brand that I adore and works wonders. I hope you could try some of their products as they are not expensive , easy to get in most countries and give us your review as they are becoming very popular rapidly perhaps because people see results as soon as first use. I use their vitamine C serum (they have different ones) so I use ascorbyl glucoside solution 12%, and they also have many others for improving the skin. I also use their matrixyl 10% with HA! They do work!!!!! 1 Reply @reshadunchained5113 @reshadunchained5113 1 year ago Imagine, having more time with your loved ones as you all age together. Science applied to a true human need. Reply @HilarieKavanagh @HilarieKavanagh 6 months ago I had a PRP injection and it put an end to 2 years of severe neck pain resulting from a car accident and I've been pain-free for 12 years. Reply @markpettus6929 @markpettus6929 1 year ago Don't look into the centrifuge with long hair! It will definitely be messy. Great , as always. Near infrared light and red light with well established photobiomodulation mechanisms with respect to skin-system health. e.g. type 4 collagen production, protection from UVB exposure, 4th phase of water bioenergetics, mito function (via cyt-C-oxidase up-regulation. and other pathways), etc. Skin, as the largest organ, with the greatest surface area, is best suited as a complex "photo-receptor", translating the EM-biophotonic environmental conditions to the biologic systems they protect. Grateful thanks for your sharing so generously. 2 Reply @poshdelux @poshdelux 1 year ago I would just like to mention... I have been getting Botox since I was 25 (im 34). I suggest you take breaks from it and interchanging it with tretinoin instead of using them in conjunction because you can become immune to Botox (and this is a real thing look it up) it stops working in some people more than others. So little breaks and interchange with Morpheus laser or other options is advantageous. Reply @djane1130 @djane1130 9 months ago Sunscreen is promoted for skin health yet I hear so much about oxybenzene I believe it’s called, being the main ingredient of most sunscreens. This ingredient is an endocrine disrupter and cancer causing agent according to many research studies. One study found traces of this chemical in the a test subject 7 days after it was applied. I wonder if David Sinclair or colleagues have information on this? 2 Reply @pattireznik5547 @pattireznik5547 1 year ago Another very interesting podcast. Kudos! 1 Reply @iqbalzaidi @iqbalzaidi 1 year ago David I have always been your fan. I am a retired senior Canadian in my 70s. I have complied 12 tips to lead a happy n healthy post retirement life. My first 3 are Money, Appearance and Health. I fully agree and believe that keeping appearance young looking fresh adds years to life. I spend lot of money on my appearance like good branded clothes perfumes shoes etc etc and think that it keeps me young. 3 Reply 4 replies @pfv1247 @pfv1247 1 year ago (edited) My non-science way to looking younger: 1- wear colorful youthful clothes, 2- eat colorful food cooked plainly or raw if possible, 3- listen to good music, 4-engage in healthy sexual release, 5-give gratitude and pass it on and forward. I see Sinclair is wearing a youthful jeans shirt: youthful vibes right there! 1 Reply 1 reply @lucycooper55 @lucycooper55 1 year ago How exciting that our ailments will no longer be dismissed as the “normal part of aging” at the doctor’s office. 4 Reply @frenchmontana423 @frenchmontana423 1 year ago okay great podcast and thanks for it. however it sucks that you guys never really got into exact detail of what you should and shouldn't eat / do for hair and skin? do we workout more? so we fast? do we go in saunas? do we take cold showers? and good too, do we eat or more greens? more eggs / biotin? do we eat less carbs and sugar? wish we got those answers. 53 Reply 3 replies @benjaminbuemann482 @benjaminbuemann482 1 year ago I watched your latest video with great interest. With regard to skin aging I would like to draw the attention to the anti-senescence effect of oxytocin on dermal fibroblasts documented in the paper British Journal of Dermatology (2019) 181, pp1216–1225. This peptide has also been proven to posses regenerative properties on different mucosal lining in several studies. I believe that if a proper vehicle making oxytocin penetrable through the skin it may be feasible to develop an effective anti-aging skin crème. 1 Reply 1 reply @dietzyfly @dietzyfly 1 year ago (edited) 0 seconds ago I have been looking at the "longevity community" for any answers on menopause. This is the closest I've heard yet--and it wasn't very illuminating. Menopause is taken so lightly, even joked about, in our culture. I could barely go to work because I couldn't sleep....I was an emotional wreck, no energy to work out, I thought I was losing my mind. It infuriates me that half the world has to suffer through hell.....very little studies are ever performed on women's health. I've been on HRT for a year now and it has saved my life. 2 Reply 2 replies @cearilindubhlaoi9507 @cearilindubhlaoi9507 1 year ago This is so helpful as a now 52yr old menupausol woman you have no idea how fast I've aged since turning 50..I'm on bio identical HRT nearly 2yrs now but it has not helped my skin my hair or nails..in fact all 3 have deteriorated bady especially my hair I've lost 50% of its volume..I used to have great thick fast growing hair ..my skin is now just sagging its totally depressing 😪..I was always a good looking woman always got attention up to been 50yrs old..I feel old and now HRT doesn't do anything to improve your skin or hair..that is my experience & my older sister... Reply 4 replies @AmazonianPower @AmazonianPower 1 year ago Great conversation! I have a question for Dr. Sinclair. It's about microneedling. Some say that even though there are positive results short term both for hair and skin there might be negative effects long term, so I would love to know what is your opinion. 3 Reply 2 replies @colleencolquhoun8818 @colleencolquhoun8818 1 year ago (edited) Great! I’m 61 and just had co2 Lazer done to my face … to help heal … she did PRP INJECTIONS INTO THE SKIN where she was aggressive and rubbed into the skin of the face then ended with red light therapy 20 minutes …just to let you know this is happening out there to the skin not just the scalp I do have an led Red light mask at home … I exercise every day for the last 40 years and I recently started fasting 1 1/2 years ( I try to lower my carbs ) So I’m feeling good and I love hearing about Dr Sinclairs studies … feeling healthy at 61 ! Thank you for all of the questions and answers Ps lost my period I. My mid 30’s so I’m working harder than most …. Haha Reply @vincentsanzone1143 @vincentsanzone1143 1 year ago Love the show guys, already spreading the word. Also just put in an order for Athletic Greens. 1 Reply @bernardsadowski6812 @bernardsadowski6812 1 year ago Excellent series!!! Please let me know if you need a model/patient/for clinical studies in whatever levels. I am a lifelong advocate of skin and hair care. I would love to talk with you about my lifestyle. A life extension customer as well. Long Island/Ft Lauderdale resident. Bravo to you! 1 Reply @bbryan929 @bbryan929 1 year ago Because of your podcast and ytube i am now aware that aging is a disease that can be treated. Reply @drbettyschueler3235 @drbettyschueler3235 1 year ago I am 78 and it takes 2 seconds for my skin to return to normal but I've been on NMN for about a year now. 2 Reply @nina-xw6ku @nina-xw6ku 1 year ago Thank you for address menopause.....would love a dedicated video on this topic from your perspective. 3 Reply @tappersuzie @tappersuzie 1 year ago no need to apologize for speaking on a subject for which you do not share the body part. An orthopedic surgeon does not have to break his/her own bones to know how to fix someone else's broken bones .... you guys are doing great - much appreciation. Reply @tatyananikolovaaddictbouti9342 @tatyananikolovaaddictbouti9342 1 year ago This is the most helpful video i have ever seen...saved me a lot of wasted money on wrong things and procedures <3 Thank You Reply @Articulate99 @Articulate99 1 year ago Always informative, thank you. Reply @KenyaBarber @KenyaBarber 1 year ago So, gents, it’s more than we have a life, and then we’re in menopause. It’s a lifelong process leading to that first year of no period (which is the definition of menopause). I appreciate you including over half the population in the discourse. Please keep it going and invite some guests on with the experience and expertise. Cheers! 1 Reply 5 replies @tedfarmer8510 @tedfarmer8510 1 year ago Hello, interesting conversation. I am especially intrigued by the hair loss portion of your talk. I am familiar with DMSO, but I’m quite surprised that you mentioned putting it on scalp, many doctors say it’s toxic, however my herbal doc has told me to use it for back pain. So I guess my question is,…. Is it safe to put this on my scalp, since it’s so close to brain. You also mentioned retinol, ….. would you put DMSO with it to help drive it into scalp? If so what formula of retinol would you suggest? Both seem harsh. Reply 2 replies @mightbeanybody @mightbeanybody 1 year ago Cheered me up. I'm 74, did the skin pinch test and it went down right away! Reply 1 reply @martinitang @martinitang 3 months ago I am grateful to have passionate intellectuals like yourself to help us care for our quality of life. Thank u❤ I wanna ask, on the subject of laser on skin, does current viral LED home device face mask work? Reply @KIYALongevity @KIYALongevity 1 year ago Absolutely amazing podcast Reply @77bonita @77bonita 1 year ago Suggestion for a topic: Any chance of a video on what to measure and tests that people may want to have from time to time and how to know whether these are legit and/or will actually tell you what you are hoping to know. E.g. would a whole body MRI every couple of years detect tiny tumours or not cos of X, Y, Z? I do hope you make a video on that. Thank you for sharing with the world so much already, though. 1 Reply @marlenedelatorre7469 @marlenedelatorre7469 1 year ago Dr. Sinclair I am on my third Month of using One Skin and also just started using their new body lotion.. So far so good.. I know products like these take time.. Reply @markvoelker6620 @markvoelker6620 1 year ago Yes, but for both Centenarians and Centurions, the salute "We who are about to die, salute you!" is meaningful. 8 Reply @lifespanwellnessbeauty-60i64 @lifespanwellnessbeauty-60i64 1 year ago I'm 61 and my skin pops back down immediately. 👍It's all about how you care for yourself. Reply 2 replies @explorersoftheworld1193 @explorersoftheworld1193 1 year ago thank you for very valuable and useful knowledge, I would be interested in the topic of fertility in women, how to care for it and whether it can be kept Reply @pubwvj @pubwvj 5 months ago Skin pinch is an interesting test. I just tried and it dropped immediately. I am almost 61. Reply @katewilson5269 @katewilson5269 1 year ago For the last few months, I've been taking one tablet each day of NMN-Vitruvin Health supplement. I'm astounded to discover that my metabolism now functions as well as it did when I was a younger. Other outcomes aren't nearly as visible yet, but I saw a significant boost in energy and concentration. I'm going to order another few rounds from their website. It took around just 3-4 days to see a difference. Reply @bigpicturegains @bigpicturegains 1 year ago (edited) I find much of this info valuable, so I am grateful for Mr. Sinclair sharing. However, the fear of protein is problematic. Even if true that you could live a couple years longer by avoiding high amounts of protein, what’s the point if we are old weak and frail without enough muscle to have a fulfilling life? 1 Reply 5 replies @GhostSal @GhostSal 1 year ago I’d recommend staying away from those heat treatments for maintaining facial collagen, after I did 3 treatments I noticed looking much older, not younger. It was a huge mistake, I looked a lot better before the treatments. Everyone used to think I was in my 30s and after only 3 treatments everyone added 15 years to their guesses.Needless to say I’m really depressed over this and don’t know how I can reverse the damage. Any advice? 4 Reply 4 replies @chrisrichardson8881 @chrisrichardson8881 5 months ago I bring back up Pregnenolone, a precursor to 150 hormones in the body. The body does moderate automatically the levels of hormones that are needed for your current stages of life. Unfortunately, the natural levels of pregnenolone declines with age and the cholesterol levels increase as pregnenolone decline. My two wives (serial monogamy) have both evaded hot flashes with the daily taking of pregnenolone, (available over the counter and only taken in the morning or early afternoon). It is an antagonist of melitonin and can break up sleep patterns. The body makes the hormones that the body needs to repair tissue and balance mood. Reply @princesscharis @princesscharis 1 year ago I am a believer at eating good portions of raw vegetables to get the vitamins and various beneficial ingredients that plant provides works like a charm as well for anti aging aside applying retinol externally. Example I took bamboo extract for a few months (and not even daily), and I measured my hair growth and I reached 1.6 cm per month. While the average is 1.25 cm. And I am 40 years old. Studies over the internet are mixed if silica from bamboo is absorbable and how much, but it worked for me. For my antiaging for my hormones, I take pueraria mirifica, but in small doses, and I will add some other herbs, but again small doses, not for breast enlargement, because it messes up my ratio with progesterone and I get delayed periods. But in small moderate doses rejuvenates me. I am a vegetarian since 31, and I do intermittent fasting mostly the 12 hour one for the last 5 years, now when I reached 40 I do the 16/8 one. I am quite happy with my skin and the way I look since financially I couldn't afford to buy expensive supplements for daily use, I will try some of the things Dr speak, like NMN now because I am more financially stable so I can afford them. But my personal diet is microgreens, the common vegetables from my garden with high levels of brix, lots of fruits nuts, lots of kale, chlorella, klamath lake sea weed, raw cacao, trans resveratrol, Ashwagandha, astaxanthin, bee pollen and pine pollen, bamboo, moringa, maca, all 3 colors, and various of oils for external use, like raspberry seed oil, avocado, etc there are so many, astragalus and various of other herbs. ALL in moderation, meaning some of them need to be taken only for 3 months at a time. Use wisely, but use them over the years use as many of herbs and vegetables and exercise keep a positive mind, a happy mind and I think we might be very close to a great antiaging recipe. I stop eating junk food, and I added like dozens of herbs and vegetables especially nuts and seeds. Now I am drinking almost every day a mix poppy seeds, bee pollen, linseed, pea protein or hemp protein, and it keeps me full and I am able to do my fasting much better than before. 1 Reply 2 replies @KotobukiGirl @KotobukiGirl 11 months ago I asked 'my' gynecologist to test my hormone levels. She said they instead look at the color of the area and base HRT on that, and they don't prescribe progesterone. She only gave me estrogen cream, which made me nervous because I've heard cancer stories. I didn't use the cream for long. I'd still like to get all these things checked and get on a good HRT program. What should I do? That experience has put me off of going to the gyno period. I haven't been back in over two years now. I am concerned about muscle loss especially in my thighs. Reply @JonnyD000 @JonnyD000 1 year ago (edited) Regarding episode 2 about eating, how would you manage to keep up your at home diet habits if you were on an extended trip 3+ months traveling? And how does the 1 meal a day mix with workout days where the exercise will likely make you hungrier? Reply @wolfpack8193 @wolfpack8193 7 months ago David Sinclair is smart and funny 😅I laughed about having long hair can be dangerous. Reply @julius1972100 @julius1972100 1 year ago New Subscriber from the Philippines🇵🇭🇵🇭🇵🇭🇵🇭 Thank you fir your informative and free knowledge you are sharing to mankind. More power to your channel 3 Reply @joannaanuwelfley4472 @joannaanuwelfley4472 9 months ago Hi Woman Here, thank you for addressing Female Hormones! All genders should care and be educated on every body. I appreciate evidence based information regardless of what gender person shares it. No need to tip toe around valuable information. Reply @leadimentoobrien1221 @leadimentoobrien1221 1 year ago (edited) I am 58, no cavities, no fillings, my hair is very dark brown and lustrous, i don't and never had to dye my hair, my eyes are the age of a 30-40-year-old my doctor told me. I only have a few gray hairs, my fertility was high right up to 55! Not much for wrinkles. bones are good, skin is good, what I use is a face gadget that vibrates as it cleans. VIBRATION from what I read vibration is highly effective. The secret is I don't do cr*p to my body. no botox, none of that. Just grateful for what I got . As I am listening to this I had NO issues with menopause. My memory is sharp, I'm very active cuz I LIKE to be active. Perhaps because I'm IRISH I like to lift weights. That is a big tip. weight lifting. Bicycling works for me and going to the BEACH set me right. Bragg's Apple Cider Vinegar with Cinnamon is beneficial. OXALATES DID do something to my body. a while ago I made spinach, carrots, onion, celery soup with pasta elbows and used the water the veggies were cooked in for the soup broth. that I suspect created kidney stones. Unbeknownst to me especially spinach is high in OXALATES. Who knew eating right could do damage to your kidneys. please research OXALATES in your lab. With everyone drinking ALMOND MILK more people are going to damage their kidneys from drinking it. Almonds are high in oxalates. My skin pinch test went down in 2 sec. I use COCONUT CREAM for coffee etc. 8 Reply 2 replies @danielfradkin3536 @danielfradkin3536 1 year ago Hello,thank for the great video.I noticed that very popular supplement for skin is biotin but you didn't mention it in your lecture.Can you comment on it?Thanks a lot 1 Reply @xeniastefanescu507 @xeniastefanescu507 1 year ago David, I am 74 and do not have grey hair.,and generally , I do not look my age., and I am not on any medication. Also . I wanted to say that I had so much stress in my life, maybe as much as the stress of 5 people, over their whole lifetime.Also I should mention that I did never smoked, or drank alcohol, or took drugs.,maybe that helped. 1 Reply 1 reply @ligiasommers @ligiasommers 1 year ago My favorite podcast , and I listen to many !!!! 🙏🏻✨🌹 Reply @MsKaterinaKo @MsKaterinaKo 1 year ago David in all his interviews lately has looked glowing, is it some special skincare or his antiaging lifestyle? Asking as it's relevant to this video! 2 Reply @jawadkarim6615 @jawadkarim6615 1 year ago (edited) Great! Great! Great! Greatest Scientist David Sinclair . I really appreciate your kind help... 3 Reply @snowwhite8143 @snowwhite8143 1 year ago So sad that I can’t get athletic greens in Africa. Thank you for this episode guys. Reply @lanir.habrock7435 @lanir.habrock7435 1 year ago Can you do an episode where Dr. David tells us his skin care routine bc he looks so young and he said he doesn't do Botox and he hasn't done microneedling! 1 Reply @canadiensuperman6496 @canadiensuperman6496 1 year ago (edited) started peptides a month ago, my hair that was thinning i am 49, started thinning at 25 but got worst at 41. My hair is getting thicker its amazing. Epitalon for 20 days 10mg per day CJC/IPA 300mcg before bed BPC157 TB500 to heal GHK cu 2mg per day for 1 month IGF1 LR3 1 month cycle 50mcg so many choices in peptides to revere aging build muscle mass and so much more. Reply 1 reply @paulkiesow7588 @paulkiesow7588 1 year ago Greetings, Dr. Sinclair. I was recently featured on DoNotAge's Twitter feed as a septuagenarian outlier [as it were] on the aging continuum. I've faithfully ingested 1 gram/day metformin for two decades, likely strongly contributing to my experience of aging. Having added 1+ grams/day NMN for seven months, my nails are clear of ridging/yellowing/thickening; this had not fully been the case with metformin alone. A most noticeable change is the complete absence of aging evidence in toenails. Your comments on skin 'snap back' were interesting to me: about two seconds now with NMN and adding collagen peptides and hyaluronic acid. If you have an interest, I will enjoy discussing with you these issues, including the SIRT6 activator I began two months ago. —Paul Kiesow Reply 3 replies @WhereNerdyisCool @WhereNerdyisCool 1 year ago Dr Sinclair, what's your view on adding collagen peptides to the diet? I've added a scoop to my mid-morning coffee and my pre-workout shake for a few months. I've noticed my nails grow quicker and my Charlie Brown bald head is actually sporting some minor hair growth. And my skin test is about 2 seconds (tent test your showed)... I'm also 52 Reply 1 reply @thatstheguy07 @thatstheguy07 1 year ago David reminds me of that friend who got stoned for the very first time and when they talk they have this look/smirk on their face where they’re about to burst into laughter over absolutely nothing at any given moment 😄 13 Reply 1 reply @Mexicolivingeveryminute @Mexicolivingeveryminute 1 year ago I had really good results from micro needling. But also, with TCA peels. Once a month on each for 6 months on and off. NOT at the same time. 1 Reply @enriqueta56 @enriqueta56 1 year ago I'm not doing any special or intentional care to keep myself young, and even like that, when I do the skin pinch test on the back of my hand, my skin returns back in place in two seconds, and I'm almost 56 years young. Reply @olaaldous9748 @olaaldous9748 1 year ago So glad you talked about estrogen and menopause!!!! Thank you!!! 1 Reply @dxcyogi @dxcyogi 1 year ago What should you look for and avoid in a sunscreen. Also what do you consider optimal D level? And should we supplement with D to get to optimal level and what helps in Vitamin D absorption. Reply @michellelouise8865 @michellelouise8865 12 hours ago Thank you so much. So helpful and interesting Reply @KenzXYZ @KenzXYZ 1 year ago as for hair loss and perhaps greying hair I have a theory that not washing them too often helps. also avoiding the BS shampoos. also avoiding hot water and hot air hair dryer 4 Reply @Greg-su8nu @Greg-su8nu 11 months ago Just recently learned about NMN plus other things. Am now almost 2 weeks into using NMN, TMG, Resveratrol, DHEA plus a few other things. Am 58, almost 59. I smoked tobacco for 45 years. Am overweight and have diverticulitis. I've been vaping instead of smoking tobacco for the last 7 years. Now, 2 weeks into supplements am going to try 2 rounds of P90X. The TMG seems to have cleared brain fog but that might also be combined with NMN. Anxious to see what this body can do over the next 180 days. Am 5'10", 224lbs. Was in pretty good shape 7 years ago. I did P90X,5 times and P90X+ once. After that I was diagnosed with Diverticulitis and haven't been able to do routine normally since. So went from 180 to 225. Anxious to see what I can do with these supplements. Exciting. Thanks for sharing all this info. Look forward to a better tomorrow. Reply @kellycoleman7361 @kellycoleman7361 9 months ago Propolis is a great wound healer and prevents infections, may be good to add in to the protocol for foot ulcers Reply @harpsickle5205 @harpsickle5205 1 year ago So, if I understand correctly based on your overall podcasts and interviews. You plan on creating a pill that will reverse your aging? Will this reverse your aging to a point that you can still eat and live life like normal? Or do you need to eat and live the strict life style as well? Reply @delaneyondreams @delaneyondreams 1 year ago Yes! good for including women. How about 70+ women? In dosages, in weight-based doses (starting at say, my 90 lbs.) and can you let us know if our Inner Age at Inside Tracker is a decade younger, how should that influence the supplements and doses we take? Reply @CookieCat2019 @CookieCat2019 1 year ago Hi Prof Sinclair, while I thank you for your great research and scientific work, I would like to draw your attention to one important aspect of your approach. By informing people about potential benefits of NMN and other molecules you are taking and not revealing the reliable brands, you are exposing people to numerous low grade or even dangerous products out there. This could potentially harm or seriously damage the health of innocent people who just want to be healthier. Why not reveal a couple or safe and reliable brands? 1 Reply @meimei2630 @meimei2630 1 year ago waiting for more episodes on this topic! 3 David Sinclair Reply @littleblackbabycat @littleblackbabycat 5 months ago I've been taking nmn and resveratrol for a while now. Love it💗 I'm 51 Reply @autisticautumn7379 @autisticautumn7379 1 year ago Fascinating, the most interesting thing that I doubted was possible was the reversing greying hair amazing . Reply @johnbrooke314 @johnbrooke314 1 year ago God bless you Dr Omole on Youtube you are really a true definition of a great man thanks for helping me get rid of genital herpes.. Reply @elss7107 @elss7107 8 months ago I love this content. I quit meat 7 years ago, i am 35 woman and look like 25. I’d like to ask, if you know some new publishing about vitiligo? I got it since i was 10, i’m going to start fasting maybe it could help. Reply @clintdodson8618 @clintdodson8618 1 year ago (edited) A huge fan of your work...Thank you!!! One quick question, does using MCT oil to mix with resveratrol make sense? Reply @mnmillard @mnmillard 1 year ago (edited) I am 62 and my skin snapped back went down in less that a second! 👏🥳 5 Reply 2 replies @stephwarren155 @stephwarren155 7 months ago Really valauble episode - thank you! Reply @ektamarya @ektamarya 1 year ago Can you please do an episode on eye aging, foods to eat, this is getting more important with everyone spending more time on screens and also with indoors and cold weather facing dry eyes. 2 Reply 1 reply @leftyla @leftyla 1 year ago Fantastic discussion. Subscribed. Reply @Blueberryminty @Blueberryminty 1 year ago so my irritatingly fast growing nails are actually a good sign... it's something to meditate about when i have to clip them again. is it the same with hair growth? the reason i keep my hair long is that i don't have to cut it in shape that often. itgrows about 20 to 25 cm a year depending how sick i was and how much stress i had. could be more, but i doubt it is less. 2 years ago i had cut it short and didn't cut it for a year and it measured up to 25 cm more, while in a stressfull year (i had my first white hairs starting to grow that year, a good few years earlier then my mom had them :-/ i was barely 36. it was a very stressful couple of years leading up to that. stress reduction and stress management has become my top priority as it had so much adverse effects inside and out. i also got my first wrinkles last year, allthough they are starting to fade again now that i'm feeling better and more relaxed for more then half a year and eating healthier again. stress is the most difficult to get a grip on, when life gives you a whole lot of lemons, but it's so important to learn to deal with it, as good health is needed to cope with stress in a helpful way, while stress eats away at your health. it's something best coped with in advance. never ignore early signs of stress ;) (i had a burn out, due to ignorance of those signs and thinking i could cope without help as i still felt healthy and strong, untill the balance tipped) Reply @davida4963 @davida4963 1 year ago Thank you for sharing your hard earned wealth of knowledge. Thank you. Reply @lunagsd4771 @lunagsd4771 5 months ago Until women’s fertility can be extended and preserved, we have not truly reached reversing or suppressing aging. What is more youthful and a sign of age than fertility. 4 Reply 1 reply @resistapathy @resistapathy 1 year ago I think that anyone who purports to know how to help people look younger must divulge any procedures they have had, like injections, skin peels, etc. Reply @hassansyed5661 @hassansyed5661 1 year ago Not only nails but hair growth is a good indication of health and aging slow Reply @frankfibonacci927 @frankfibonacci927 1 year ago Thanks for the great info. What do you think about facial exercises to preserve youthful appearance? Reply @eliana2383 @eliana2383 1 year ago (edited) What about put tretinoin (topical retinoids) all over your body to reverse the sun damage and to prevent skin aging? also could be helpful to take oral retinoids (isotretinoin) at a lower dosage to do it better? (for this second option there is a brazilian study) Reply @fionmor4893 @fionmor4893 1 year ago I'm wondering if DMSO could push the HA into the skin for a better result instead of injecting?... for those who don't know.....DMSO is Dimethyl sulfoxide is an organosulfur compound with the formula₂SO. This colorless liquid is an important polar aprotic solvent that dissolves both polar and nonpolar compounds and is miscible in a wide range of organic solvents as well as water. It has a relatively high boiling point. 2 Reply @jpintero6330 @jpintero6330 1 year ago Melissa55 here on YouTube has used Retin A everyday for 38 years. She looks about 40 and it hasn't hurt her one bit. 3 Reply @robertfrapples2472 @robertfrapples2472 7 months ago I would guess Dr. Sinclair's age to be about 53 from his appearance. Never owned sunblock. Haven't been to a doctor except for small injuries since I was a child. I firmly believe that putting any chemicals on the skin causes more problems than if fixes. Reply @mikebreen4756 @mikebreen4756 1 year ago Thanks so much for this invaluable information. Would like to hear about photobiomodulation / near infrared sometime. Reply @kingbile5846 @kingbile5846 1 year ago Hello David Sir, I am 21 years old guy from India. I was suffering from insomnia for 1 year now. My doctor given me a prescribed antidepressant name dosulepin 75 mg. I wanted to know weather it reduce my life span or can cause some serious disease that can lead to death later in life Reply @bjspeck4337 @bjspeck4337 1 year ago (edited) I'm 71. Is it too late to use the combination of estrogen and progesterone? If the hap cell affects bone and muscle can it be used to fix arthritis? I have a very bad shoulder and my upper back/neck. I have used stem-cells to fix my left shoulder which worked pretty well, not so much with my right shoulder, haven't tried it on my spine. Insurance companies don't cover this. Reply @joshannon6148 @joshannon6148 1 year ago I'm 80. The skin test took me 5 seconds! Reply @chefchef9 @chefchef9 1 year ago Regarding senescent cells, are they somehow related to general (superficial) skin problems such as acne or smaller, finer scars or other potential issues? And related to that, do you suggest activating autophagy via e.g. fasting could help with such issues? 3 Reply 1 reply @sethflix @sethflix 1 year ago I'M REEEEEEAAALLLLYY enjoying your podcast@ Thank YOU! 1 Reply @jeffreymckenzie3961 @jeffreymckenzie3961 1 year ago Could listen to these guys all day 1 Reply @krauterzimmer2627 @krauterzimmer2627 1 year ago Kudos to adressing female hormones too in this episode - u read the comments from previous videos! Reply @samreenfatima2551 @samreenfatima2551 1 year ago Hi David, Can you expand a bit more on Infrared light lamps people are talking about so much all around? Are there any real scientific benefits of it? 2 Reply @indiegold7153 @indiegold7153 1 year ago Here is why everyone should listen to D Sinclair...glowing white teeth, looking 30 at 50+, bone structure. BOOYAH! Reply @JeffNixonComedy @JeffNixonComedy 1 year ago Black coffee and Sinclair podcast... the new Wednesday morning ritual 14 Reply @katherinemoreland8184 @katherinemoreland8184 1 year ago An excellent episode. Reply @djskitz0 @djskitz0 1 year ago Is there a supplement that will slow the grey process? I know we are on the verge of a huge discovery but wanted to check if there is anything we should be taking now? 1 Reply @Maria-sz1fc @Maria-sz1fc 1 year ago From the paper of Mariana Boroni: "Rapamycin caused a detrimental effect in overall skin structure, including a a thinner and more disorganized epidermis" Reply @shorts_luv7634 @shorts_luv7634 1 year ago Thank you for your valuable insights to atheism aging process Reply @marilynmarsh596 @marilynmarsh596 1 year ago I am taking a capsule recommended by my optician, and my hair colour is starting to return to what it was. Reply @dr.sammypryor @dr.sammypryor 1 year ago (edited) As a naturopathic doctor, I want everyone watching this to know that menopause is not a disease. If you are in menopause early because you had to have your ovaries removed, then yes you need Bio-identical hormone replacement therapy (BRT) not HRT. If you have a lot of symptoms from menopause then please come to a naturopathic doctor because HRT has been linked to many cancers and your risk of strokes and other CVD events. 4 Reply @dcyrene @dcyrene 9 months ago Isn’t it true that menopause impacts the heart and brain among other organs? Also, I propose that as SCIENTISTS, you would be able to talk about hormonal changes in women IF this process was studied (as diligently as is ED?) Reply @loridouglas5576 @loridouglas5576 1 year ago Why is it always ‘suffering’ through menopause? As someone who’s ‘survived’ I would suggest that it can be seen as a natural transition and a part of graceful aging. 7 Reply 3 replies @gloria6396 @gloria6396 1 year ago THE 2 OF U TOGETHER R WONDERFUL FOR ME 2 UNDERSTAND I WISH THIS WOULD GO LONGER THAN 8 PODCASTS Reply @mpmrevolution @mpmrevolution 1 year ago Great podcast and inspiring,maybe someday we drink pill and we can rejuvenate in a year or so Reply @MrHomerdog1 @MrHomerdog1 1 year ago LOVE the Spock joke! Great podcast, thank you. Reply @sellaghazouly @sellaghazouly 1 year ago Can you add Arabic translation please I love your videos so much but sometimes I can't understand little of words thank you for all things ❤️❤️❤️ Reply @pinkberrydigital2237 @pinkberrydigital2237 1 year ago I’m a 45 year old female and I fully plan on being a Centenarian. I’m gonna refuse to die and dammit, I plan on feeling and looking as good as possible the whole way 😌😌😌😆😆😆 2 Reply 2 replies @stargazerbird @stargazerbird 1 year ago So the things you can actually do right now are well known already - retin a, sunscreen, red light, controlled skin damage via needles or laser, Botox, minoxidil for hair growth plus HRT. Oh and the usual sleep, exercise, eat well, don’t stress. Maybe PRP? 3 Reply @christinasmith9368 @christinasmith9368 1 year ago I think you will find how spending time on women's issues can really help your following. ;) My endocrinologist recently told me that I either go through menopause or I am dead; that is life. Ok. But I want to avoid the symptoms/suffering my mother experienced for over a decade! HRT triggered a thrombosis and she nearly died...so I want to proceed with caution. It seems I appear younger than my age and as such get little sympathy from my gyno who has passed menopause and this older man endo. Apart from other hormonal and PMS issues, my testosterone and DHEA measures high, so I fear male pattern hair loss as my estrogen lowers -so loved this podcast. I wish I could find a medical team who didn't treat me like a hypochondriac and/or resent me for wanted to optimise my health!!! Reply @michelem226 @michelem226 1 year ago Avoiding too much saturated fat can also slow hair loss, because too much saturated fat reduces blood flow. Reply @LTPottenger @LTPottenger 1 year ago I do lots of red light/near infrared. Great for skin and also joints and wounds. 3 Reply 2 replies @lordjamescbeeson8579 @lordjamescbeeson8579 1 year ago Your amazing, I spent hours listening to you on other podcasts and wondered if you had one, and you do! I took notes! I never take notes. lolol Reply @isabelcamera9216 @isabelcamera9216 1 year ago When you mention female researches could you please give their surnames? It's difficult to Google about them just by their 1st names. Other that that, Looove your cast. Depply appreciated Reply @ahmadal-essa1875 @ahmadal-essa1875 10 months ago Would you please talk about liposomal delivery of these molecules such as NMN, HA, Resveratrol...etc? Reply @tammybott9968 @tammybott9968 1 year ago I was taking bio identical hormones for 9 months. I had to stop when I was diagnosed with breast cancer. My surgeon attributed my cancer to the hormones. I wonder. Nonetheless, they remain off limits for me. 1 Reply 3 replies @GreenTara2010 @GreenTara2010 1 year ago (edited) Broad band light facials aka photofacials are approved by the FDA for antiaging. That and the microneedling are the best antiaging procedures. Perhaps some anti-aging skin creams work too. Reply @parksumin9910 @parksumin9910 1 year ago Thanks again Dr. Sinclair! What do you think about pregnant woman who are taking NMN or other molecule such as resveratrol, fesetine, quercetine.. 1 Reply @williamdeoradesilva9444 @williamdeoradesilva9444 1 year ago Thanks guys, super podcast. Reply @katniss4670 @katniss4670 3 weeks ago (edited) Can Retin A be applied all over the body ? How much of it is absorbed and can it be toxic in larger doses ? Reply @standupeight299 @standupeight299 1 year ago I liked how Mathew switched from ‘poopoo’ to ‘denigrate’ without missing a beat 😂 1 Reply @kapa0224 @kapa0224 1 year ago DR. Sinclair, is there hope that in the future, it will be possible to grow cartilage in a hip and avoid joint replacement? Are you currently doing any clinical trials now to particioate in? Thank you! Reply @natalieaxl804 @natalieaxl804 1 year ago Thank you Dr, David 🙏 1 David Sinclair Reply @solaris4015 @solaris4015 1 year ago I believe that the 12 am sun, everyday, for 20 minutes, is the best due to max exposure to UVB (the one that produces VIT D). One question I have is: Is there such a thing as "sun ormeses" ? Reply @TMiller808 @TMiller808 1 year ago I’m a 49 yr old half Hispanic, half white decent, I tan easily and get pale easily. I live in Hawaii. I’m menopausal and have hyperpigmentation. I’m wondering what is the healthiest, non toxic, natural sunscreen? Like super natural and can I make one? Reply @annettesichamba6041 @annettesichamba6041 1 year ago Thank you for your knowledge shared. Reply @helenmcintosh9747 @helenmcintosh9747 3 months ago hi Dr Sinclair been watching from Australia you have saved my life i could not walk i had so much damage to my bones i take Metformin i have some respertol i do everything intermitten fasting eat vegan now. i now am now so much fitter my specialist was amazed i needed double hip replacement in 6mths i dont need operation anymore i am back riding pushbike i am 66yrs i feel like 40s thank you so much x Reply @sonals2021 @sonals2021 1 year ago I am glad that you mention women, quite important to note research where only men have been tested and how a particular drug or protocol may affect women. 4 Reply @vitalrestandrecoveryclinic7752 @vitalrestandrecoveryclinic7752 1 year ago So excited for this one! 2 Reply @michelles2299 @michelles2299 7 months ago I eat a balanced diet which includes fish, fruit, and always a full broccoli steamed every day, no added salt no bread. I use spf every day, I use tretinoin 0.01% at night, I walk 6 miles everyday and lift weights twice a week that's the best I can do Reply @wigglywrigglydoo4735 @wigglywrigglydoo4735 1 year ago Might be a little off topic. But anti aging seems to be a promising field for peyronies disease. Reply @huiyingtanyayap @huiyingtanyayap 7 months ago He is 50 ? Omg ! He looks like 30 ! He is definitely the aging expert ! 1 Reply 1 reply @jessicabender1301 @jessicabender1301 1 year ago Dr. Sinclair: I have bad reversal of my grays, now to blonde and brown again. This occurred when I upgraded my lifestyle and with each pregnancy. Please explain how. Reply @bsaldy @bsaldy 1 year ago (edited) I checked one skin brand that you were saying for one it is too expensive and number two i checked the ingredients, there's not much of a star ingredients. Retinol is still the gold standard. And your eye brow is not moving. Did you had botox. 3 Reply @teddyli4763 @teddyli4763 1 year ago Thank you to athletic greens for sponsoring this Reply @chucklohn522 @chucklohn522 1 year ago I wish you guys would have discussed some of the Liposomal NAD+ skin creams some more. I would like to hear your opinion on it. I am trying some of the skin care products from "Renue by Science." Thief Face and Body Serums. Reply @michelles2299 @michelles2299 1 year ago My grandma died at 84 she had a small sprinkling of grey never died her hair she used olive oil Reply @LTPottenger @LTPottenger 1 year ago Niacinamide cosmetics also probably helpful, don't think that was mentioned. You can get niacinimide very cheaply in bulk and add it to an oil too. 3 Reply @cjcj2010 @cjcj2010 1 year ago Fertility also decreases because of lack of zinc and iodine (and other nutrients) from food, greatly negatively affecting fertility, thyroid, etc. Reply @paulsansonetti7410 @paulsansonetti7410 1 year ago avoiding PUFAs ( approximately 33% of the American diet per Dr Michael Eades) though extremely hard, is absolutely essential for skin health, lipofuscin and liver spots ate basically PUFAs + iron high amounts of coconut oil baths in borax pregnenolone can have a " facelift" effect high dose niacin works great to get blood to the dermis due to its vasodilating effects Reply @carolineduncan1637 @carolineduncan1637 1 year ago I’ve read that hylauronic acid causes cancer. Please can you address this maybe in next season? Thanks a lot Reply @ciarog6116 @ciarog6116 1 year ago Hi, I was wondering...if the skin is all one organ, why doesnt using retin A on your face improve the skin on your legs? Reply @mariabatlles7032 @mariabatlles7032 1 year ago I'm almost 63. The skin on my hand sprung straight back. :) Reply @sean640 @sean640 1 year ago I hope Australian free sunscreen is coral reef safe because that stuff definitely bleaches them even at low concentrations 3 Reply 2 replies @octaviano1296 @octaviano1296 1 year ago (edited) David Sinclair looks at least 8 years younger than his chronological age. Reply @simonewright1120 @simonewright1120 6 months ago I'm a 54 y.o. female...my skin turgor is that of a 20-30 y.o. It untested within 1 sec. So it may not b that "bad" for others our age. Reply @deela3615 @deela3615 1 year ago Dr. Sinclair looks very young, but for his podcast he should make sure the colors around him and on him match his cool undertones. He would look even younger and healthier. He might consider consulting with Jennifer Butler, I believe she in in California or another professionally trained Color Therapist. Reply @raoaman @raoaman 1 year ago My grand maa is 120 year old...she never used suns cream ..worked in the sun with the cattle..her secret is working and drinking lot of home brewed tea 2 Reply @crowdancer5 @crowdancer5 1 year ago Stopped at 43 minutes to make this statement....I am female at 78 years of age....they took my ovaries about 22 years ago and have been on HRT since....believe me, I have not noticed looking younger...(than what?) but when some doc thinks I am on too high a doseand tries to cut back on them, I go into a total tailspin....physically and menially......I must wonder however, any of the topicals you are speaking of, for someone my age seem silly....I am not hearing you speak of anything other than facial creams....skin is not just on face and neck and I doubt any of us are going to be spending the money on facial cream all over the body to make for healthier skin! I understand this is dealing with "looking younger" but a makeup artist can do that....cmon, give us elders something to really chew on! Nowhere in any of the discussions have I heard mentions of the fact that elders lose much of their ability to properly digest nutrients and thus the body not having the raw material to build healthy bodys...skin and all. The studies are nteresting but can we get down to the nitty gritty here and speak to those of us who are already what society calls old. You so often do speak of male...and in the age bracket of mid life....50s or so....lets reach the elders too! Both male and female! 120 Reply 17 replies @ginacardarella @ginacardarella 1 month ago (edited) I've been waiting for this please please more about menopause!! Reply @heatherd1583 @heatherd1583 1 year ago Have you studied the science behind DefenAge’s defensins? I have my own theory on retin-A. I’m not a fan of daily or every other day, retinols. I think retinols cause inflammation and inflammation is not something good long term. I think it’s better to rotate, use for 3 months and then three months off (use peptides, AHA, or soy type products depending on the person). What do you think about that? Reply @mustavogaia2655 @mustavogaia2655 1 year ago I've once consulted Dr. Sinclair: "Doctor, do you have something that would make me more handsome?" He asnwered: "Do you know that what I do is science and not magic, right?" Reply 1 reply @alamnoorsandhu1192 @alamnoorsandhu1192 1 year ago How does cold and hot exposure effect the skin ageing ? Like cold showers and sauna ? 1 Reply @annewilliams741 @annewilliams741 1 year ago Love the topic. Lots of info 1 Reply @rashadaliyev2674 @rashadaliyev2674 1 year ago Thanks for the content. Lots of knowledge, but almost zero actionable information. This is a consistent trend on this podcast. Please consider sharing more actionable info. 4 Reply @sheri969 @sheri969 1 year ago Amazing work! Reply @aiculsunlight9713 @aiculsunlight9713 8 months ago I would love to know what Dr Sinclair and his “lovely” co-host think of the new series Limitless with Chris Hemsworth ! Reply @RB-mr6cr @RB-mr6cr 7 months ago I am 58, never got hot flushes, never use HRT, I eat natto, tofu, tempe, kimchi and sauerkraut as part of my diet. Reply @athleticbodyshape @athleticbodyshape 1 year ago If you look after your health you don't need replacement therapy. Also its never too late to look after your health. 1 Reply @nicolematthews5930 @nicolematthews5930 1 year ago What physician is the best one to see in order to have these tests done to check hormones? My MD and even my gynecologist did basic tests and didn't seem concerned, but it is clear that there have been major changes hormonally. Reply 1 reply @RunToTheHills999 @RunToTheHills999 1 year ago Live long and prosper 5 Reply @greenLaVitameadows @greenLaVitameadows 1 year ago I have enjoyed as always ! Thank you ~ 1 David Sinclair Reply @Lioness1965 @Lioness1965 1 year ago I have a question: I've had beautiful long, hard nails my whole life, and then my father passed. It's been 2 yrs, and my nails have not grown since. I've tried biotien, iron, silica, and nothing works. Thoughts? Direction? Reply 1 reply @ArtiumLifshin @ArtiumLifshin 1 year ago Hi, how does berberine compared to metformin? Are there any downsides to Berberine according to science? Reply @samuelhajduk5746 @samuelhajduk5746 1 year ago Skin is only skin deep. The real driver of cosmetic aging at least in the face is Bone loss. What about aging of the bones? I read some studies that report that nad+ boosters and senolytic drys can revert at least some of age related bone loss. 3 Reply 4 replies @pete8009 @pete8009 1 year ago Dr. Sinclair, is there any way you can influence InsiderTracker to lower their prices? It would be great to make that test more affordable to all (the margins seem extremely high). 11 Reply 1 reply @douglas.abramski @douglas.abramski 1 year ago Maybe hair growth in different areas (inside the nose for example) have a purpose like extra filtration of external debris or particulates? 1 Reply 1 reply @ellencollins4528 @ellencollins4528 1 year ago It makes makes me a little happy to inform you really, really smart guys that you are wrong about the largest organ in the body. The vascular endothelium is the largest organ in the body. The vessel wall is 5 times the size of the heart in mass and 6 times the size of a tennis court in area. The vessel wall is an active, integrated organ composed of three separate layers: intima, media and adventitia. 2 Reply 1 reply @user-sb9ml1ef4q @user-sb9ml1ef4q 1 year ago hands down my favourit channel now =) I just really like you guys. Reply @stephenlucier @stephenlucier 1 year ago Fantastic as always boys! Reply @leadimentoobrien1221 @leadimentoobrien1221 1 year ago I think the butane in grass-fed, grass-finished organic butter is good for preventing aging Reply @tonying1672 @tonying1672 1 year ago Thank you for the information. Is it true that Retinol and Retinoic acid are deactivated by any form of light and therefore be applied at night when you are ready to go to bed? Reply 1 reply @dollyvandenbrink5211 @dollyvandenbrink5211 1 year ago Wish I knew All this Info when I was young, Thanks dr David Sinclair. Reply @Cattttttt11 @Cattttttt11 1 year ago Dr Sinclair please talk about whether it is safe or not to replace estrogen and progesterone post menopause using cream, and if that should stop at any certain age due to risk of Breast or gyn cancers. Reply @mjquin85 @mjquin85 1 year ago I’ve heard that adhd medications age you, is there any way to combat this? Reply @duanefrench3500 @duanefrench3500 1 year ago Hey David, I wonder why you have never heard of Redox Biochemistry/ ASEA? It has done wonders for me. You talk about these molecules you take, but you never mention the name of them. 3 Reply @moniquecobb9051 @moniquecobb9051 1 year ago I’m 49! No one ever believes me & took this photo 6 mos ago w no filter. I use The Body Shop Vitamin C moisturizer day and night. I also use $9.00 Collagen cream from Walmart. Works wonders!!! Good luck.💋 2 Reply @westcoastgangster @westcoastgangster 1 year ago Soooo, what's the verdict on micro needling? Is it effective at anti-aging for the skin? 1 Reply @kinanisam4345 @kinanisam4345 1 year ago This broadcast could use Dr. David Sinclair presenting on his own, “Huberman Lap” style. He is being interrupted way too often, unfortunately. 3 Reply @leadimentoobrien1221 @leadimentoobrien1221 1 year ago doesn't the GFR value contribute to the aging process. Im a blood donor and read that after donating your GFR can go down to 55 or so. It did. then after I panicked, after I read that info I got it up to 61. it may have been dehydration after donating that I did not drink enough. Reply @christinadubois3556 @christinadubois3556 1 year ago Excellent podcast series question please do you see any value in red light therapy Reply @WildGamez @WildGamez 1 year ago Why do I keep saying "Oh david" whenever I watch these amazing podcasts Reply @l.pmoonstone5067 @l.pmoonstone5067 1 year ago A few months ago, I bought a bottle of wine. The cashier asked for my identification. I said to him '" whaaat?! Are u serious , you want to see my I.D? How old do I look?" He said I look very young. wow, I must be doing something right. I am 40 yrs old Reply @ColettaDesign @ColettaDesign 1 year ago Love you two. Thank you. Reply @cyndijoylee @cyndijoylee 7 months ago Just did the skin test and I’m a happy camper…At 65..my skin ? I’m a happy camper…my skin returned to normal immediately. Reply @johnsnitus8442 @johnsnitus8442 1 year ago (edited) Fucking love this guy so much. David you are a hero. Reply @guitarista666 @guitarista666 1 year ago (edited) OK, this is audacious of me, but I think they are making a massive blunder on the skin test. I'm nearly 80. So, when I take the skin test on the back of my hand, yes, a very poor recovery rate, but when I do it on a part of my body that is usually shielded from harsh chemicals and the sun, like my lower abdomen, then the recovery is like a teenager's. So, all the hand test does is show what harsh chemicals and the sun will do. 1 Reply @ledam2654 @ledam2654 1 year ago Menopause starts in mid to late 40s and 50s. There are women all over in non-western countries who are having healthy children in their 40s and 50s. A woman experiencing menopause in her 30s is a medical anomaly (through no fault of her own, though.) Reply @orion10x10 @orion10x10 1 year ago 1:09:20 "if you can keep yourself looking good by doing the right things you'll probably end up living longer too" That makes sense, so many centenarians (people who are 100+) used to be hot Reply @katharina1439 @katharina1439 1 year ago I'm 38 and Look young (like 30) but I don't have children yet! Aging is so scary. I want a child but also a good husband and father. It's not fair that woman's eggs and ovaries age earlier. I wanna lear more about reverse aging your female parts. I hate intermittent fasting🙈 but will do the rest... Reply @falconone7230 @falconone7230 1 year ago (edited) What about phytoceramide supplements made from rice and sweet potatoes? Will that be beneficial? Also would Amla extract supplements help with reversing grey hair? 1 Reply @jacquelinesheridan8114 @jacquelinesheridan8114 1 month ago I recommend prp. I had hair loss last year and I tried prp. My hair grew back completely. Reply @polinaplatonov502 @polinaplatonov502 10 months ago In a nutshell, how to improve skin and keep it young based on the interview? Apply sunscreen, resveratrol, nmn. What about collagen intake? Yes or no? Reply @shaynadavidovhansonrealtor @shaynadavidovhansonrealtor 1 year ago Fascinating and wonderful content… Reply @doth4580 @doth4580 1 year ago Prediction: In a couple of decades this guy is going to look accordingly old and he is going to do the same talks about how you can become younger. The worst thing is that some will still take him seriously. Reply @jennym4127 @jennym4127 1 year ago I disagree that centenarians look younger. In the photos and videos I’ve seen the centenarians look pretty awful, with red eyes, thin mottled, discolored, saggy skin with dark lesions, causing them to look exactly like what they are: 100 year old people! I’m glad they are biologically healthy, but they do not look younger. The only clear cut effective way to prevent these super discouraging results of a long, healthy life seem to be medical interventions including dermatological and surgical interventions. It seems that such interventions also provide a mental health boost which is “ nothin’ to sneeze about.” (PS: my grandmother in law lived to be 105 and remained healthy until the last 9 months. She also had breast cancer at 95–non invasive— and lived another 10 years. She birthed 11 children, was a hard worker, and loved to fish.) 4 Reply @amanihassan9298 @amanihassan9298 6 months ago please elaborate more on balancing female hormones at menopause. Hormonal therapy is not safe since i have no idea what normal levels are for my body. too late to measure when you are 50. what is the alternative? hair loss and skin deterioration and lack of sleep are major issues. Reply @DomDocuments @DomDocuments 1 year ago Switched to the carnivore diet and all my skin problems went away. It is now thicker, hydrated and I don't ever use sunscreen. Most sunscreens are toxic. Reply @marinamansour6219 @marinamansour6219 11 months ago Can Azathioprine also work to restore hair color? Reply @Oresehpe @Oresehpe 1 year ago I hope you've both considered taking your massive following and have people volunteer to conduct the worlds largest and longest longevity research Reply @staninjapan9 @staninjapan9 1 year ago Has David admitted to Botox? His occipitofrontalis and orbicularis oculi are totally paralyzed, causing a kind of sinister look. Not hating, but it would have been far more interesting to see his progress without dyed hair, fillers, and neuromuscular blockers. He is starting to get a bit of a Hollywood vibe rather than a naturally aging well 52 year old. 4 Reply 1 reply @missmerbella @missmerbella 1 year ago Dr. Sinclair, I've read Retin-A actually thins the stratum corneum. This isn't a concern because overall it still increases collagen and skin thickness? 1 Reply @eugenmuzica8608 @eugenmuzica8608 1 year ago So tretinoin (retin A) is bad for you or its still good to use once in 2-3 days ? Age 25 4 Reply 1 reply @laurensargent9471 @laurensargent9471 1 year ago So what should someone like me who had PCOS, kids at 40 & 44 (#2 at home with a midwife and no meds), didn’t go through menopause until 55 do now 10 years on? Is HRT a good idea at this point? 1 Reply 1 reply @AnkushSharma-zv5hv @AnkushSharma-zv5hv 1 year ago once more, let's go david and Matthew Reply @JustAWomanAging @JustAWomanAging 1 year ago So I promote you on my podcast my YouTube channel and my TickTock channel. I have 27,000 followers on my TikTok and one asked me a question today when I posted what you said about growing hair with monoxidal and Tretinoin. The question one person asked was if you stop using the tretinoin and the minoxidil does your hair fall out? Thank you 😊 Reply @romanb6810 @romanb6810 1 year ago “Not like today, you just let kids blow in a wind” 😅 I dont know about US, but in Czech we still have to put solid effort to raise a kid 😂 Reply @natala2u @natala2u 1 year ago Dr Sinclair, when you talked about RetinA, you said the cream 0.5%, is it correct ? or 0.05 ? thank you ! Reply @SkateNCreate90 @SkateNCreate90 1 year ago In terms of minoxidil which is talked about it around the 55 minute mark... hasn't it been proven that it can significantly age the skin and cause wrinkles? Even dark circles? 1 Reply 2 replies @CuriouslyChris1 @CuriouslyChris1 1 year ago Correct! I’ve seen Paper Skin Tears! 1980s. Decubitus, amputations, This is a great episode! Reply @MrGriff305 @MrGriff305 1 year ago (edited) This is a profitable thing to discuss and write books about. I'll bet there's even venture capitalist money to take. He's a clever little quack. 3 Reply 1 reply @paulmr6667 @paulmr6667 1 year ago What about Reishi mushroom for preventing/reversing gray hair? Its a known Inhibitor of DHT. Might want to check that out 2 Reply @AdrianneMays @AdrianneMays 7 months ago Would you say that thyroid supplementation via T3/T4 would be considered an adversity mimetic or an abundance mimetic? I can see some arguments for both. Reply @1LaOriental @1LaOriental 1 year ago I’m 63 and the skin turgor test for me is 1 second. Reply @buybuydandavis @buybuydandavis 1 year ago Is it better to cycle between growth and autophagy? Reply @parkerreed4370 @parkerreed4370 1 year ago great video! thank you. Reply @MrDadude123123 @MrDadude123123 1 year ago Did someone managed to formulize a PRACTICAL takeaway? I.e. what options of available treatments for what types of anti aging? 3 Reply 1 reply @ferravenclaw8436 @ferravenclaw8436 1 year ago Can u please talk about coffee and ADHD medication on aging and lifespan? 🥰🙏 Reply @victorabadia9700 @victorabadia9700 1 year ago Levels not available in Puerto Rico ! My Identical twin brother lives in the south west and I live in Puerto Rico we were hoping to compare data. Still love the work you guys are doing. Reply @upstream1942 @upstream1942 1 year ago What is the mechanism behind the common hairloss in elderly females? Reply @asiaisreal7302 @asiaisreal7302 1 year ago I wish I knew that Retinol was Vitamin A I used a retinol product after using Vitamin A and my skin dried out so bad I had to shave my face, steam it and drench it in Coco butter and Castor oil. Reply @kastarzan5748 @kastarzan5748 1 year ago hey dave, can you guys talk about the direction of cosmetic medicine is goin, where ppl can alter there appearance. For example increasing adult height, muscle enhancements etc. Iv read a company in south korea has patent on increasing adult heights. Thanks Reply @linda.harwood @linda.harwood 1 year ago I'm Australian and I haven't seen any sunscreen dispensers on the beaches in Australia. If you come to visit an Australian beach please bring your own sunscreen 🏖️😊 Reply @deliaocampo4340 @deliaocampo4340 1 year ago Looking younger in the genes too the wrinkling of the skin even the greying of hair blessed to inherited from my parents the hair from my dad the skin from my mom 20 yrs.or more looking younger and to add slim and trim🇸🇽🇺🇸 Reply @sclakdar6858 @sclakdar6858 8 months ago Hyperbaric Oxygen heals ulcers extremely fast. Surprised to not hear it mentioned. Reply @SkipYearSix @SkipYearSix 2 months ago Does Accutane/Isotretinoin effect longevity? A drug that’s used by many young people to treat acne. Shrinks oil glands throughout the body… It would be beneficial for many people to know if this does long term damage to health. Reply @johncoe6304 @johncoe6304 1 year ago Outstanding info Reply @abdelilahbenahmed4350 @abdelilahbenahmed4350 1 year ago If I were bald I would never think about blaming my beloved mother for having transmitted to me the genes of alopecia.Instead I would be immensely grateful that she gave the gift of life with the grace of God. Reply @mariashumyatsky264 @mariashumyatsky264 1 year ago I had my skin destroyed by a couple of really aggressive cosmetic procedures. Is there a way to reverse that. I had really healthy and young skin and then turned old within minutes. It is systemic damage, on cellular level, hair also. Would you advise? Reply @thetraveler79 @thetraveler79 6 months ago I'm kind of new to the channel but now addicted lol. Reply @leadimentoobrien1221 @leadimentoobrien1221 1 year ago Bone broth? Kefir? Fermented foods? 5 Reply @jimfife6255 @jimfife6255 1 year ago Yeah, Rapamycin inhibits mTor but Tacrolimus is a calcineurin inhibitor. Both suppress T-cells +/or B-cells, in high, frequent doses. Maybe that's the effect in the scalp? Reply @RuchiinChina @RuchiinChina 7 months ago (edited) Dr Sinclair seems like he is actually ageing backwards. He looks much younger than before Reply @barbaralanzante5619 @barbaralanzante5619 1 year ago David Sinclair please can you please if you don’t have the answer but I’m very curious on bio identical hormone therapy 3 Reply @NikkiSchumacherOfficial @NikkiSchumacherOfficial 1 year ago Everyone says I look so young but I feel old. Idk. My mother looks very young but she's not in good health either. We have arthritis issues- mine have been controlled largely with meat based and gaps diet. Reply @lauragitchel2882 @lauragitchel2882 1 year ago Yes to sexual health. Let’s talk about vasodilators:-) Reply @suzettemills5822 @suzettemills5822 1 year ago Poor people think about what they can buy with their money, Rich people think about what they can invest in with their money 💰💰💰; 26 Reply 15 replies @stevey1970 @stevey1970 1 year ago "And then you have to put a lot of effort raising kid, It's not like an insect just let them blow away in the wind"😂 Reply @pontevedra660 @pontevedra660 1 year ago aaaahhh Doc, you are so sweetly great in your advertisements..... I trust you with my life, as you have led me, inspired me, through so many hurdles in my life. 1 Reply @angelinashaw2592 @angelinashaw2592 1 year ago Hi, pls have more podcasts, do you have a skincare line yet, if so please let me know, tks, I love all your info 1 Reply @geraldtong4414 @geraldtong4414 1 year ago Hi Dr Sinclair, with the near future age reversal treatment, will women be able to give birth after the age of 40 years old and above? 1 Reply @funtimes3962 @funtimes3962 1 year ago How many people pinched their skin? Thumbs up if you did 3 Reply @flyingsneetch @flyingsneetch 1 year ago Hi! I just went to Inside Tracker, and the discount they offer is 20%, whereas Dr. Sinclair says it’s 25% when mentions the sponsors at the beginning of the podcast. Just FYI so maybe you can fix that :) 1 Reply @angiedamian681 @angiedamian681 11 months ago Does the presence of prickly heat on the thighs in a 64 yo woman indicative of ageing? Or is this only an adverse reaction to irritants like temperature, chemicals etc. Reply @KJ-um1gq @KJ-um1gq 1 year ago What about consuming beta carotene instead of using topical retinol? I drink lots of carrot juice 🥕 Reply @littlevoice_11 @littlevoice_11 1 year ago What are your thoughts on light therapy for skin aging? 1 Reply @petedawson5875 @petedawson5875 1 year ago Future vampire checking in 8 Reply 2 replies @gdpierce01 @gdpierce01 1 year ago In an interview I saw recently with nutritionist Trudy Scott, she said ingesting collagen can lower serotonin levels. True? Reply @Ishtanara @Ishtanara 10 months ago (edited) Unfortunately too many physicians are extremely uneducated on the use of HRT for women and outright refuse to provide for women, especially in some countries. Women shouldn’t have to fight to get this help especially if they are healthy in other ways Reply @glatzefratz8492 @glatzefratz8492 1 year ago Oral minox (loniten) works for hair growth - but maybe not the best idea for improving the skin..? 1 Reply @MM-qg5xh @MM-qg5xh 1 year ago Love the topic! Appearance DOES matter! 2 Reply @nieczerwony @nieczerwony 1 year ago I think that quite important thing hasn't been discussed and this silicon in terms of ageing of the skin and other tissues. Reply @spengali857 @spengali857 1 year ago Women, today, are not going through menopause, at 40. They are having babies in their 40’s. Need to update your science! 6 Reply 1 reply @montypalmer4556 @montypalmer4556 1 year ago Skin peels can remove the upper most damaged layer with regrowth coming from less damaged cells. 1 Reply @patrick815 @patrick815 1 year ago Pound-for-Pound David is the best PhD. Reply @kokolove9542 @kokolove9542 1 year ago I hope you read this message. How do you get rid of excessive moles all over my neck and stomach.. started to come in my 30's. My mom doesn't have them 😕. 1 Reply @dlbdlb3919 @dlbdlb3919 1 year ago I'm 78 and my skin pinch test was 1 second or less Reply @catday5939 @catday5939 1 year ago So instead of just giving us information and advice, we have to listen to a long justification of why an issue that primarily affects women is important. The sexism of the host who states how he needed to be convinced to have any interest in the subject is evident, not least because female hormones were considered an aside and a spill over from the last episode. I don't know about anyone else but I'm really getting sick of macho dude bros monopolizing self improvement/care to women's detriment and not including us with parity. 8 Reply 4 replies @kit2253 @kit2253 7 months ago average age of menopause is NOT late 30s/early 40s. it’s late forties to early 50s, with the average age being 51. Reply @cearilindubhlaoi9507 @cearilindubhlaoi9507 1 year ago Please Please talk about Menupause more ...what women need to concentrate on at this stage to make life easier mentally physically and emotionally..its a really hard sad time ...xx much respect 👏 🙏 Reply @janetbederman3924 @janetbederman3924 1 year ago When you are healthy, you look good. They go together 1 Reply @coricori7428 @coricori7428 1 month ago I love to hear David sinclair talking his work and what and how to use it all. Greatful for. Iit So interessting and My question is about ha filler for tear line under 1 eye. Is there a way to improve the longevity of the filler because it does not stay there as long as i think IT should thank you Reply @jeannienelson1035 @jeannienelson1035 1 year ago I stopped using Retin A and switched to acid peels. My complexion is much more taut , smooth and bright with no discoloration. Should I go back to Retin A??? Reply @Rex-lq1oj @Rex-lq1oj 1 year ago Do you happen to have any info on how to get rid of acne or what it means to have it? Reply @SeviYoga @SeviYoga 1 year ago Subscribed!! I appreciate your work and your looks!!! Reply @reemsouliman2573 @reemsouliman2573 1 year ago Hello doctor! I have a question how to avoid Vit B12 deficiency if we take metformin with our meal Reply @curious1264 @curious1264 1 year ago Is it possible to find out the best topical with small chain hyaluronic acid and reversitrol? Reply @RisqueBusinessNews @RisqueBusinessNews 7 months ago I am living for the little digs between these two. Reply @lauramakin834 @lauramakin834 1 year ago Thank you for this lads : ) Reply @goldgold4943 @goldgold4943 1 year ago Pls make video on functional medicines... Any also ways to improve eye health 1 Reply @eyeandmind @eyeandmind 1 year ago (edited) Enjoy having a cup of coffee and listening every Wednesday at 8 AM. 1 Reply @tgulley6753 @tgulley6753 1 year ago Hello, What about botox for eye twitching. Do u know of this? What is your opinion? Thank you for this podcast, I am learning so much. Reply @jessicadeben @jessicadeben 1 year ago (edited) Can you include lasers and Broad Band Light medical spa treatments? I just had this treatment done and WOW. I follow Dr Patrick Bitters work and the Stanford University clinical studies show evidence that BroadBand Light Treatment Promotes Youthful Skin on a Molecular Level! Reply @MrAnaelimont @MrAnaelimont 1 year ago In what form and what dose reversetol would it be beneficial for woman to take for antiaging? Reply @OddMickel @OddMickel 1 year ago lovely podcast ;) Reply @debbiem6637 @debbiem6637 9 months ago Just wonder if the Athletic greens is the only supplement I need? I am also looking at NAD and resveratrol. Reply @OldNewMama @OldNewMama 8 months ago Please talk about reversing fertility age. 🙏🤍 Reply @lorrains.robinson1404 @lorrains.robinson1404 1 year ago i use topic retinol 2 times per week, should I stop using it? I got very confused at that part. Reply @philllove528 @philllove528 4 months ago Thanks...i watched your interview in India.... Appreciate the knowledge. Reply @machka888 @machka888 1 year ago great topic and episode thanks Dr Sinclair but i thought you’d address lasers and PRP ? also did I understand you correctly that senolytics are effective on skin rejuvenation when used topically ?? really? Reply @istvangondocs5996 @istvangondocs5996 11 months ago Can everybody drink Atheltic Greens independently from special diseases i.e. cancers? Is it necessary to drink it permenantly (being that is is expensive) or is it enogh to drink as a terminated cure? David, I've whatched a lot of your videos, You really look younger than two years ago when I recognised You on the Internet, seeking for selftherapies on prostate cancer! Bought Your book Lifepsan - first in English later in Hungarian when it was translated. I am one of your believers whithout doubts. Question: I cannot find enough signes related to the nutritians often mentioned in reports whether in cancer are the dangerous or not or only helathy people can take them (resveratrol, metformin e.t.c.) (Unfortunatelly my experience is that most of doctors do not meet it so far here.) Reply @infora789 @infora789 1 year ago What to check regarding liver health ? Especially if always tired Reply @nasmeana @nasmeana 1 year ago I am using issotretionoin, 15 months already, also fast at least 16-18 hours and often do OMAD and use retinol 1 to 2 times a week. is this contraproductive? Reply @viraldhanani @viraldhanani 1 year ago What about Glycerine for skin? Surprised not to hear about this ingredient which is present in almost every skin care product! Reply @vg1403 @vg1403 1 year ago Hi ! Does anyone knows how many hours of fast can start Chaperone Mediated autophagy (CMA) ? How is it different from Micro & Macro autophagy (in a layman's terms plz) ? Gains & benefits of CMA over other autophagy ? Reply @cheekybastard99 @cheekybastard99 1 year ago Can anyone speculate why the researches attempted to disguise Tracolimus for reversing graying? Reply @GreenTara2010 @GreenTara2010 1 year ago I bought the One Skin cream David mentioned. It got good reviews. Reply @everend_xyz @everend_xyz 1 year ago 31:44 is retinoids are retinol cream ? Is there a difference between retinol and retinol-a? Thanks Reply @caseyplanck6005 @caseyplanck6005 11 months ago I want to ensure I understand the reversing of hair graying....if you are fasting regularly, eating whole food plant based meals low in sugar it can reverse it? Reply @hectora.vasquez3281 @hectora.vasquez3281 1 year ago Great info! Ty! David Sinclair Reply @claudiajap427 @claudiajap427 1 year ago David sinclair , is so cute and soft spoken. He is like a weird child , smiles very little🙂 Reply @joanmaloney1189 @joanmaloney1189 1 year ago I question your statement thhat Botox and lessoning wrinkles can enhance your social life. Any studies on that ? I love your podcast Reply @JRLB38 @JRLB38 1 year ago Liked my Levels. Became a little addictive, checked like every 15 minutes🤭. Reply @machietheapachie7214 @machietheapachie7214 1 year ago (edited) You guys really need to address dry fasting as opposed to wet. Waaaay overdue. Great stuff btw 1 Reply @nothingness4884 @nothingness4884 10 months ago This guy is over 50, looks 32. I think I will carefully listen to whatever he's saying. 1 Reply @humu1345 @humu1345 1 year ago So stoked just found This!!!! Reply @irenereyesvlogs2809 @irenereyesvlogs2809 1 year ago amazing, dr sinclair looks very young, I never thought his on his 50s, i thought we have the same age😂30s Reply @Cheree_Wright @Cheree_Wright 1 year ago (edited) I believe David just said we shouldn’t use hand sanitizer in this video. Of course I want to know why. I’m assuming it ages the hands because it’s so drying and may even be absorbed into the bloodstream? Reply @delaneyondreams @delaneyondreams 1 year ago Where can we find more on how Infrared Saunas work? Since Dr. Roger Seheult published on MedCram "Light As medicine" we have daily SUNRISE BATHS (before 9 am) and we bought and assembled an Infrared Sauna after Rhonda Patrick's fabulous video on the topic that encourage healthy seniors to enjoy them for their many benefits. Reply @paulaukena2654 @paulaukena2654 1 year ago THANK YOU SO MUCH 😊 Reply @WeirdAlSuperFan @WeirdAlSuperFan 1 year ago If you're underweight and, say, under 35, is building muscle and strength training (and upping your calories/protein) really that bad for you??? Reply @kerryjean2223 @kerryjean2223 1 year ago I believe hair greying can be reversed by eating cooked mushrooms x 1 Reply @vonsabido2281 @vonsabido2281 1 year ago Imagine if they made an all in 1 pill Reply @Shrimping @Shrimping 1 year ago 2022, life changing information wrapped up in a Canadian tuxedo. 🙂 1 Reply @SquatFull @SquatFull 3 weeks ago I would appreciate a response to Dr. Charles Brenner's Article "Sirtuins are not conserved longevity genes" Life Metabolism, Volume 1, Issue 2, October 2022, Pages 122–133. Reply @helenduyvestyn @helenduyvestyn 1 year ago Was the early hair loss not related to Accutane? Reply @lauriemeunier567 @lauriemeunier567 1 year ago So David you mention fasting for 3 days to upregulate autophagy. Is it just water or would athletic greens be allowed? Reply @nicamike2459 @nicamike2459 1 year ago David looks like he’s 12. Impressive. 1 Reply @gp246 @gp246 8 months ago Can broken capileries on face be healed through skin cell regeneration? Reply @marianr8617 @marianr8617 1 year ago Is there more recent literature on topical retinoids and hair loss? That article is from 36 years ago- 1985. Reply @waynr @waynr 1 year ago 55:46 you say that laser treatment has "been approved by the FDA", can you clarify whether it has been approved as safe vs approved as effective for hair loss? My understanding was that it's only been approved as generally safe, not necessarily effective for treating hair loss. 2 Reply @tomc1121 @tomc1121 6 months ago This is from a Facebook friend.... I love talking about this but talk is cheap, let's get moving on these therapies. Since early childhood, I have had faith in the power of prayer. I even keep a prayer list and usually pray privately except, of course, with other believers in religious services. The time has come that I must request those who are willing to join me in prayer for my husband Bill who became blind several years ago. There is no cure . In addition, he suffers incessant pain in various parts of his body so that the joy of living is gone. Would you join me in praying for relief from pain for Bill and all who suffer from whatever takes away their joy of living? Jesus performed miracles in New Testament records and God can perform miracles today . Can we pray together in faith? Reply @ezl6307 @ezl6307 1 year ago Can you go through a blood test for us and tell what your biological age is Reply @davidhill6960 @davidhill6960 7 months ago Researcher Ray Peat asserts that naked mole rats are very long-lived ostensibly because they live underground in a CO2 rich environment (similar to long-lived queen bees). Rather unattractive gregarious critters, but it’s said they live well beyond their cousin moles and mice. Reply @yl5757 @yl5757 1 year ago Thank you so much! Reply @Snapkrackpop @Snapkrackpop 1 year ago with respect to serum alpha melanocyte stimulating hormones: how can these be increased? what is considered too low for libido, hair color, appetite suppression, etc... 1 Reply @natesofamerica @natesofamerica 1 year ago Is it specifically lasers or is it also NIR and red led lights of a sufficient power density? Reply @marsery @marsery 1 year ago (edited) So Dr Sinclair do you take catalase to fight white hair ;-)? And I suspect you've read my comments on a previous podcast as you're addressing all the points I've made : thanks! Reply @agneslaufer9579 @agneslaufer9579 1 year ago Regular workouts, low carb diet with variety of veggies no fruits Taking care of skin on daily basis Drinking water 1 Reply @xenosonic @xenosonic 1 year ago Born and raised in Australia and never once have seen free sunscreen at the beach. Reply @JkBee @JkBee 1 year ago (edited) Can you please explain whether the protocols are safe for breastfeeding and pregnant women - eg metformin, fasting, also effects on fertility. Reply 1 reply @LisaAnnRay @LisaAnnRay 1 year ago What about red & near infrared light therapy for the face aging? Reply @danadanaher9733 @danadanaher9733 1 year ago Can you please link the study referenced regarding alcohol and skin aging? TIA Reply @brettarogers144 @brettarogers144 7 months ago Nail growth can be stimulated by Silicon (Dia- atomic Earth) - what does that say about the nail growth test for aging? Reply @manuelojeda9144 @manuelojeda9144 1 year ago I just turned 70 I punched my hand and it went down I one second. I'm super healthy. 1 Reply @GreaterGoals @GreaterGoals 1 year ago Best color for David - this blue. Looks cool & younger Reply @ilhamalhassan2571 @ilhamalhassan2571 1 year ago Thank you Dr David Sinclair Reply @lullasierra1 @lullasierra1 4 months ago Can anyone name his company or website where we can buy his products? Reply @jakubmalinek8324 @jakubmalinek8324 1 year ago It's a pity that levels or inside tracker are only provided in US and Canada. Reply @birgik @birgik 1 year ago I'm 53 and skin pops right down. Reply @jeanwroberts @jeanwroberts 1 year ago Bruises on fruit are actually a sign of high levels of antioxidants! Reply @malgosiaur9780 @malgosiaur9780 1 year ago more about menopause pleaseeeeee Reply @jeffvonfuture @jeffvonfuture 1 year ago Hello! What about color light therapy on the skin? like red light therapy. I have seen other colors like blue, purple and green beeing apply with a mask Reply @MrAnaelimont @MrAnaelimont 1 year ago Can you guys talk about any down falls of fasting and woman (premenopausal). Since woman are cycle beings and are more sensitive to physical stress is fasting causing too much stress in a woman( Reply @infowazz @infowazz 11 months ago (edited) I'm 48 and hair is thinning at the temples. I have a conehead and look horrible without hair!!! I was in the military so i know how i look. I cannot go bald!!!!! No no noooooo. Hair started to gray in my late 30s. It seems like more and more people are turning gray sooner. Most guys my age look much older and have a dad bod. I'm pretty ripped. I also don't eat breakfast or wait a few hours until i eat. I now like hunger pangs and going through it. I think denying your body like that is a good thing but you have to be smart about it. Watch your blood sugar, hydration, etc. If you are doing something strenuous like working out then you obviously need calories. Reply @legolas8025 @legolas8025 1 year ago What is better Reseevatrol or OPC? Reply @malgorzatakrala1316 @malgorzatakrala1316 1 year ago Would you be able to add the link to research about alcohol impact on ageing please? Reply @marianasalles242 @marianasalles242 1 year ago A plant based diet helps a lot in having a healthy, active, cleaner life🌍🌱🙏🏻💪🏻 🧠 Reply @productvisibilitytvshoppin1107 @productvisibilitytvshoppin1107 1 year ago Is there any evidence that these changes in diet can increase your testosterone levels and improve your sex life. If so, can you expound on those issues please? Reply @Gmgl1981 @Gmgl1981 1 year ago How is it possible to get MNM and know that what you are getting is pure and of quality? Reply @chrisotc6832 @chrisotc6832 1 year ago David Sinclair is maxed out on botox.. and definitely has had work done! 🧑‍⚖️ Reply @jt3221 @jt3221 10 months ago 55:08 Trying finasteride is not a risk people should take lightly. 1 single pill can crash your endocrine system and give you terrible side effects, even if you're perfectly healthy. Reply @allisonblaustein7898 @allisonblaustein7898 8 months ago (edited) -Suggests estrogen & progesterone replacement long term for women with measuring / tracking. Caution if history breast cancer. - Repair skin damage with peptides including topical retinols ( avoid eye , moisture on top of and sunscreen) vitamin c topical & ingested & possibly by ingesting collagen. -Don’t waist time on anti oxidants - Hyaluronic acid highly effective topical ( resveratrol ingested can boost HA internally & topically) - Botox & peel : temporary, external fix. No medical benefit. -Micro needling may ? Have long term medical benefits? Makes sense but not proven. - Alcohol ages. ( small amounts Pinot Noir may be fine ) - Rogaine does work for hair growth. Retinol applied daily reduces wrinkles and increase hair growth. Low laser light Therapy/ Red laser light has been proven to slow down hair loss and help new hair grow and some saunas have it. Platelet rich plasma is effective. Can reverse greying if start early 1:00:00 - get enough sleep Reply @tomscott3 @tomscott3 8 months ago 2 things: - this doctor is 50 years of age and looks 30 - these podcasts are like drinking from the information firehose 1 Reply @jred3642 @jred3642 11 months ago I really feel it’s important to highlight, not being a woman, doesn’t mean you can’t lecture on the biology of women. If you have the knowledge, share it. If what you’re stating is based on real data, then it can’t be opposed simply because you’re a male. Reply @bigblockjalopy @bigblockjalopy 1 year ago I know 25 year olds who look older than Dr. Sinclair at 52. Impressive. That said, he does make a big mistake. Skip Dinner, not Breakfast! Reply @samford5153 @samford5153 1 year ago Question... If our nose and ears don't stop growing all of our lives, in the future when we double our life span will there be millions of people with massive conks and lugs at age 160? Reply @seekingthemiddleway4048 @seekingthemiddleway4048 1 year ago The fertility window for women is vanishingly small, and not always convenient for modern women. If humans start extending lifespan I wonder if fertility will last longer as well one day. Hope so. Reply @verderne @verderne 1 year ago Thanks you guys! Reply @akyraider1972 @akyraider1972 1 year ago One question @dr sinclaire . Will this be relevant that more we ejaculate shorter will be our lifespan ? In your book you mentioned that the species who reproduce very fast and more have short lifespan Reply @hamirmahal6615 @hamirmahal6615 1 year ago To clarify, at 52:32, the quantity 9.8 to 15.8 nanomoles per liter is the optimal level for testosterone, and not dihydrotestosterone (DHT), correct? The study linked in the description says, "Testosterone (T) levels decline with age and lower T has been associated with increased mortality in aging men. However, the associations of its metabolites, dihydrotestosterone (DHT) and estradiol (E2), with mortality are poorly defined." The only reference to "9.8 to 15.8" on the page says, "Instead, an optimal range of circulating total T corresponding to a range of 9.8 to 15.8 nmol/L (282–455 ng/dL) exists for older men, which predicts survival independent of other risk factors." Reply @evaa.6754 @evaa.6754 1 year ago Thank you so much 💓 Reply @Sharperthanu1 @Sharperthanu1 1 year ago For women there isn't lack of sex drive!.What there is instead is potential partners they don't like or could care less about as people. Reply @scarletletter2847 @scarletletter2847 1 year ago "Drug mimics fasting," rejuvenating the skin. Maybe intermittent fasting is a cheap healthy natural alternative. Conversely, perhaps snacking all day is metabolically aging? 1 Reply @mahnazalsharif1954 @mahnazalsharif1954 1 year ago This is a question for David sinclar: there is evidence that fasting particularly 3-7 days is associated with osteoporosis. How can then fasting be justified particularly with postmenopausal women? Reply @angiedamian681 @angiedamian681 1 year ago We’re talking about getting molecules from the outside into our bodies to reduce the rate of ageing. That’s cool enough but doesn’t that negates the fact that our bodies only needed food and exercise for so long to stay alive and now we’re looking at outside manipulation to instruct our cells to continue staying alive? What ever happened to our cells that we now depend and rely on human intervention when it has thrived for so long without it in the earlier stages of life on earth? Something seems wrong here. I maybe wrong but we’re overlooking something in our biology and humanness that makes us focus only on the seen stuff and ignoring the unseen ones. Thank you for your great content. More power! Reply @ScottSummerill @ScottSummerill 1 year ago Didn’t Dave say on the very recent Huberman podcast that he drank? Not gonna go back to confirm but it was red wine. I believe. So … what changed? 1 Reply @coffehbear3359 @coffehbear3359 1 year ago I hope I'm not cursed. I am a female who has gotten to 49 and don't have my hormone levels baseline from youth, but am going to rush to find out. Reply @yvonnenovakmatz2319 @yvonnenovakmatz2319 1 year ago Very surprised by the nonchalance with which you discuss immunosuppressive drugs. These are medications with a multitude of side effects, closely monitored in the clinical setting and dosed carefully. These drugs also generate the need for therapy pre-screening and vigilant surveillance for cancers, due to immunosuppressive action. You are a professor of genetics—not a pharmacist, physician, health clinician, or oncologist. I am confused by the expert stance you take beyond your personal scope. 2 Reply @sooooooooDark @sooooooooDark 5 months ago 33:33 if u want ur nails to grow faster: take silica supplements if i had to guestimate how much faster they grow id say 60-100% somehow rda for silica isnt established 😂 Reply @dalemarie9150 @dalemarie9150 7 months ago How does eating vegan raw food until dinner compare to total fasting until dinner? Reply @rachelb7068 @rachelb7068 1 year ago I was wandering if NMN is safe to take with MSM?? 🙂 Reply @MattMick @MattMick 1 year ago (edited) Bit of a contradiction here with alcohol and an earlier episode about red wine and resveritrol. Didn’t David previously say he enjoys a glass of red wine but he’s saying here he’s given up alcohol? Some clarification please? 1 Reply @reverseaging5387 @reverseaging5387 1 year ago I see Matthew likes Austin Powers movies.... Humor is important to slowing down aging too! LOL Reply @mediacenter3174 @mediacenter3174 1 year ago (edited) it's very very odd that a well known doctor with millions of dollar companies need to add sponsors, Like a teen age Tiktoker Reply @kelliinman9041 @kelliinman9041 1 year ago Surly people mention you look like Christian Slater! Your videos are fantastic👍🏻 Reply @renanhuguinin8967 @renanhuguinin8967 1 year ago So retinol has a lot of benefits to skin and collagen production but also block autophagy making the skin age faster? How can i read more? I'm 27 and my skin is good, so i don't need retinol? Reply @liquidbrainstorm @liquidbrainstorm 1 year ago I respect David and he's got good advice. But he literally looks older than he actually is. So does that mean he would just look even older if he didn't do all these things? Or none if this stuff is working? Reply 1 reply @stacy3581 @stacy3581 1 year ago Not sure about the nail observations ...if I take k2 my nail growth explodes ...but I don't think (unfortunately) that will correlate with my biological age? Reply @monicazamudio1447 @monicazamudio1447 1 year ago Is retinol safe while being pregnant? Reply @battledino @battledino 1 year ago Does taking collagen pills works to look younger? Reply @sonnymatthews5452 @sonnymatthews5452 1 year ago (edited) Can telomeres be repaired, if so how much does this change your epigenetic clock? 1 Reply @nostalgia545 @nostalgia545 1 year ago So many people are dying from lack of nutrition and from war, but here is this guy trying to just prolong his life and look young. How is Kim Kardashian seen as vain but not this guy? Reply @dynacerocentaprovidentteam @dynacerocentaprovidentteam 1 hour ago Is Super Oxide Dismutas an essential Anti Oxidant for Longevity? Reply @bellakrinkle9381 @bellakrinkle9381 2 weeks ago In the 90's were doctors not saying women have healthy babies between 25 - 42? What's changed? Aside from the reality that more women wanted to establish their careers, first. I hope someone replies to this question. Reply @hopecarlson1231 @hopecarlson1231 1 year ago Clicked so fast! Thanks again for the great info! 1 Reply @fatimafreire2841 @fatimafreire2841 1 year ago 👏👏👏👏👏❤️ Reply @teddyli4763 @teddyli4763 1 year ago The levels app sounds really interesting Reply @africanchina1 @africanchina1 1 year ago starts in 13:00 Reply @channel-so2st @channel-so2st 1 year ago Does athletic greens have heavy metals like the other green supplements? Reply @DrGayleDelaneyDreams @DrGayleDelaneyDreams 2 months ago INFRARED SAUNAS: We bought one 2 years ago and as we learned more about the benefits of Near Infrared Light (NIR) we sadly discovered that the Far Infrared light (FIR) is all we have in our sauna! The manufacturer told us that the FIR light is more efficient in heating up saunas to 140. Rhonda Patrick thinks so far, that this heat level is inadequate to achieve the many benefits, so she uses a traditional sauna that allows 175 degrees and above. She has a friend who is now studying infrared saunas, but apparently has not yet published. It may be possible to find the right NIR wavelength and red light panel to install in our FIR Sauna. I would love to hear what you have to say about the photobiomodulation (formerly, Low Level Laser) research! Very exciting! It is very difficult to find and evaluate the online advice regarding the red and Infrared light products for home use! Reply @AnnTsungMD @AnnTsungMD 9 months ago DAvid looks so young! Reply @aglayapiano @aglayapiano 2 months ago Can you please confirm, that NMN and Botox cannot be used together? Thank you Reply @dawne66 @dawne66 1 year ago Thanks so much, gentlemen. Content great but hating the plugs for products or services where you do have some interests. 1 Reply @MM-qg5xh @MM-qg5xh 1 year ago "And if it doesn't work it'll just feel longer" LOL 2 Reply @user-es4ri5zu4k @user-es4ri5zu4k 1 year ago Some of the advice, particularly related to skincare, is a bit too textbook. Go to reddit or other skincare dedicated channels on YT for interventions that work, and work well. Reply @everend_xyz @everend_xyz 1 year ago How do i know how much metphormin to take? Or at least try to take. I remember David once said he takes 1g per day, I believe. Reply 2 replies @tknzdworldfirstidentylinke6404 @tknzdworldfirstidentylinke6404 1 year ago He is not really interested in anti aging of skin but super interested hair loss Reply 1 reply @edwardnino9896 @edwardnino9896 1 year ago A question about red laser light, you mention the beneficial effects of red laser light, to be clear you mean true lasers versus red led lights of which there are numerous brands of red led devices. Reply @gaston. @gaston. 1 year ago interesting new info... thanks for sharing Reply @dcyrene @dcyrene 9 months ago Also, what do you think about TA65? Reply @TheTalia2 @TheTalia2 1 year ago What brand of bone broth is the best, most pure, keto? Where can I get genuine wholesome/home made// bone -broth soup, without MSG? Which company is most PURE authentic? Asking for health reasons: Not interested in soup mixes. Thanks for your help. Reply @yourcoachbladimirsantos5136 @yourcoachbladimirsantos5136 1 year ago Does anyone knows where David is getting the supplements from? Reply @Samuel-yt9ty @Samuel-yt9ty 1 year ago Great to see Fred Durst again. Reply @littleblackbabycat @littleblackbabycat 5 months ago Yes. It's time to look into women's hormone health and change generic traditional medicines Reply @steves8014 @steves8014 1 year ago Please devote more time to the eyes. Very interesting! Reply @ozztenn @ozztenn 1 year ago Bringing back the 90's Levi jackets... 2 Reply @talksick508 @talksick508 1 year ago What do you do if u had overexposure to retinoids? Vitamin a I don’t want to make me worse Reply @barbaralanzante5619 @barbaralanzante5619 1 year ago What about bio identical hormone replacement for women that are going through menopause or who are in menopause? By doing this does it change the entire human body is a dangerous? Reply 1 reply @TheGoby @TheGoby 1 year ago Thanks guys, love you 😘 Reply @silasaskjrmidtgaard8478 @silasaskjrmidtgaard8478 1 year ago The really Nice Co-host Matthew reversed his age so much, his voise started to crack again (48:08 in the video) Reply @ryanbadeau2330 @ryanbadeau2330 1 year ago I see Rogan and Huberman told Sinclair to get the SM7B. Reply @jasonkeck3438 @jasonkeck3438 1 year ago Anyone know about the oral bioavailability of hyaloronic acid? They didn't touch on that. Reply @KitasakuOnlineKO @KitasakuOnlineKO 1 year ago (edited) I watch the entire ad on these videos to support the channel more Reply @pearlcharkow2093 @pearlcharkow2093 1 year ago Please share which sunscreen you use? Thanks Reply @bloominghealthboomingwealth @bloominghealthboomingwealth 1 year ago Sir I am learning Molecular Pathology Masters. I wish to work with you. Please contact me. Reply @nabilaray7967 @nabilaray7967 1 year ago amazing info ,,green juices are a must ..i add protien to them ....😃 Reply @sydcar9893 @sydcar9893 1 year ago Everyone should be watching this!! Reply @spyman52 @spyman52 1 year ago (edited) Comments on astaxanthin for skin protection and, possibly, aging, if you two would. Reply @andreasstuermer4946 @andreasstuermer4946 1 year ago This DNA test from insidetracker ... is it measuring the Horvath clock? According to all the CpG sites that Horvath uses? Reply @dd-dd2co @dd-dd2co 1 year ago which NMN brands do you recommend? thanks dr. Reply @leadimentoobrien1221 @leadimentoobrien1221 1 year ago what about REBOUNDING? A.k.a. TRAMPOLINE exercise which I hear is good for the lymphatic system Reply @kristykaley6465 @kristykaley6465 1 year ago Can you use Oneskin Os-01 if you get fungal acne?! Reply @jameskeller8282 @jameskeller8282 10 months ago David I need to know how much reversitrol is needed per day. And if I run out will the results reverse them selves Reply @chantalpique @chantalpique 1 year ago What about Own Fat Injection for Filer into face or hands? Reply @BadMannerKorea @BadMannerKorea 1 year ago (edited) I get Botox and I’m planning on getting broadband light treatment. 2 Reply @craigcrawford6749 @craigcrawford6749 1 year ago Sinclair really pushes his ideas but pooh poohs others. Reply @paulsansonetti7410 @paulsansonetti7410 1 year ago keto or carnivore for blood sugar baths in borax and topical coconut oil/tea tree oil for the ulcers /biofilms Reply @emmanueltrejo3531 @emmanueltrejo3531 1 year ago Go Sinclair! Reply @peterhicks5590 @peterhicks5590 1 year ago get somebody to do a painting of you and then put it in the loft ,it worked for bloke called Dorian Gray ! Reply @libbycollins9349 @libbycollins9349 1 year ago Is there research on effects of taking NMN and resveratrol on thyroid function with Hashimoto Thyroid Disease and low thyroid? Reply @johnmartinsen7623 @johnmartinsen7623 9 months ago Why are you afraid to have a conversation with Dr Paul Saladino? He makes some good points that you clearly don't want to acknowledge. Upton Sinclair said it best..."It is difficult to get a man to understand something when his salary depends on his not understanding it." Reply @yvettep1093 @yvettep1093 1 year ago The only thing I do not agree with Dr Sinclair is the use of Metformin and Statin drugs. The neurological issues with these two drugs far outweigh the benefits of his NAD precursor supplementation and Resveratrol Reply @carlosserrano829 @carlosserrano829 1 year ago As of right now the age reversal isn't available for the masses only the elite of the elite. U can only stall it or slow it down.and you can do that with frequencies and molecular telomeres therapy that uses vibrations(frequency) can also reverse if you tune the frequency to the correct hertz. Any supplemental or medication can't alter the human genome 🧬 at least not by the ones offered to us.there's gene editing but can't stop the aging process just yet.again not for us but for the ones that have power and the ones that control technology. It's all about vibration (frequencies) morphogenetics manipulation. Reply @ginacardarella @ginacardarella 1 month ago Its a Shane that we have to take this upon ourselves and spend out a pocket. Money that there is no coverage for aging. The healthcare system we have in place sucks Reply @eikajung5486 @eikajung5486 1 year ago Matthew saying he “poo-poo’d” this topic offends me. Reply @general-economics3794 @general-economics3794 1 year ago Thank you Sir 1 Reply @sandraslutz9489 @sandraslutz9489 1 month ago Just wanted to thank you and your company MetroBiotec for getting NMN banned in the USA. I guess your book "Lifespans" and its recommendations aren't worth the paper they're printed on. But hey, at least you'll get rich while people succumb to aging. Reply @joeblow1748 @joeblow1748 1 year ago I suspect micro needling will help. Not shure but every since ive heared about it ive seen old people on the telly that used to look lile shit but now look naturaly young again. Micro nedling makes sence to me because you "punch out" old damaged cells and force the body to tranplant and fill the holes Reply @jomx @jomx 1 year ago Hey David. I am a very big fan of your content and I want to listen and trust your advice, but I have to say that I don’t particularly enjoy what you are doing in straight up copying basically everything from the HubermanLab podcast . As a pioneer in many different areas of the modern health, especially the anti-ageing field, I expect you to develop your own style and not follow what others do. I mean, wasn’t that your whole way to approach life and science? Do not take the shortcuts, if you really believe that you have the best content, people will come, sponsors will follow, and most importantly of all, you will feel like you really created something great that belongs to you. 2 Reply @saraheart2804 @saraheart2804 1 year ago My 100 year old grandmother is laughing at this. Reply @lakid9749 @lakid9749 1 year ago I think as a female i would have liked the same amount of a deep dive on skin as with male baldness. Seems like the guy In the cap speeded through the skin part then nit picked hair loss. Which is weird cause He could have a pod cast about HAIR LOSS itself??? 1 Reply @josecunanan9269 @josecunanan9269 1 year ago I donate blood plasma to the red cross twice a year.. Will this have an adverse effect on my own health? Reply @Sharperthanu1 @Sharperthanu1 1 year ago Please Google:sun exposure causes skin and eye aging.Also please Google:microneedling. Reply @ajl8615 @ajl8615 1 year ago Why is it not talking about Radio Frequency device and Microcurrent device for removing wrinkles, lifting the face, getting rid of eyes bags? These are most important for women, boldness isn't the essence of issue. Dr Sinclair please talk about those devices nowadays millions of women even men are using the devices. Thank you. Reply @seona6549 @seona6549 1 year ago I embrace my "silver"hair🤗😊 1 Reply @erika8884 @erika8884 1 year ago I would have been one of the women who died in childbirth if I was back in the times where assistance wasn't available. Not all women are built inside for bearing children. Reply @ticketforlife2103 @ticketforlife2103 1 year ago (edited) Minoxidil almost killed me lol. Please look at the research of Rosemary oil and it's effects on hair growth compared against minoxidil5%. Reply 1 reply @delaneyondreams @delaneyondreams 1 year ago NAILS? 1,000-5,000 mcg of Biotin (Vitamin B7) has transformed my nails that first yellowed, flaked, and softened in my 50s. My Dermatologist suggested Biotin at 300mcg daily for 3 months trial. Nothing. So I went to 1,000 mcg and saw good results in a month or two, then to 5,000 when the store only sold that. Now I see bottles at 10,000 mcg tabs! Is there an upper safe limit? in 2008 I saw a warning on a bottle on 1,000 mcg to stop taking before any surgeries because Biotin thins the blood. Since then I have not found any warnings, nor a doctor who can answer the question. So, we amateurs need help in dosing at different body weights, (please remember those of us who weigh 90 lbs. and are female) and dosing for different ages and states of health and inner age estimates. Most docs seem to go by estimates for 150 to 175 lb. males. I once dated a wonderful cardiologist from Lucca, Italy who loudly lamented how few docs in the US were attentive to these important distinctions. Any help you can offer to educate us would be so welcome, as is your site and your work together! Reply @LeoL0804 @LeoL0804 1 year ago Please make a video on how to restore vision and cure myopia🥺 2 Reply @wspyogi @wspyogi 1 month ago (edited) Retinae 31:38 - retinoids Reply @yints322 @yints322 1 year ago NmN can cause cancer ? Heard a lot about this problem. I have been taking nmn for few months. Reply @peterschmid9878 @peterschmid9878 1 year ago What brand of hair dye does David Sinclair use? 2 Reply @leadimentoobrien1221 @leadimentoobrien1221 1 year ago I would think if you were researching aging you would study the microbiome, stool samples, digestive system...... Reply @AQWCHEATS101 @AQWCHEATS101 1 year ago No mention of the positive effects of redlight on skin health? 2 Reply @1LaOriental @1LaOriental 1 year ago What about Castor oil for hair growth? Reply @gotomars2969 @gotomars2969 1 year ago Great thank guys! David Sinclair Reply @zioncityofgod4818 @zioncityofgod4818 8 months ago I also have an enlarge heart. How can I apply to the trials on human? Thanks for your attention. Reply @ELM711 @ELM711 1 year ago Will inside tracker give you a baseline of hormone levels? Reply @teodoravukovic4643 @teodoravukovic4643 8 months ago Such a good illustration that medicine is about men. Thanks and goodbye! Reply @bella-wt6xo @bella-wt6xo 1 year ago (edited) Why your sounds quite low? It’s not my phone cause it’s fine and Loud on other channels, But l love you anyway Dr Sinclair you the Best thank you 😊 1 Reply @zbridgjpxupzm @zbridgjpxupzm 1 year ago "Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men" any comment on this study? 2 Reply @rosyloveslearning3013 @rosyloveslearning3013 1 year ago 🙏🏼 Reply @edrock4605 @edrock4605 1 year ago These guys must be the life of the Party. Reply @buddyrevell511 @buddyrevell511 1 year ago At some point those youtubers promoting techniques for appearing younger are themselves going to have to look very young for their ages. Otherwise, few will buy what they are selling. Reply @richard18219 @richard18219 1 year ago Is inside tracker available in the uk? Reply @SL-bu6qj @SL-bu6qj 1 year ago Do we know if he uses XR Metformin? Reputable brands of NMN and Resveratrol? Hard to find 1 gram in few capsules and COAs can be forged or old. Reply @penelopefrias1828 @penelopefrias1828 1 year ago I have a macular degenerative disease, when can we expect the lab vision experiments will be available for people? Reply @jbird4754 @jbird4754 1 year ago I bought AG, love it but couldn’t access Dr.Sinclair’s code for discount 🤷‍♀️🥺 Reply @janetbederman3924 @janetbederman3924 1 year ago So can I add some resveritrol powder to my lotions? Reply @urbanart7325 @urbanart7325 1 year ago what are the risks of long term HRT therapy Reply @lonesomesundownjr @lonesomesundownjr 1 year ago I really wish that Matthew LaPlante had asked Dr. Sinclair if he has had any botox treatment for his forehead and crow's feet area? Reply @nature-zp7pc @nature-zp7pc 7 months ago does eating less often stimulate producing insulin? Reply @JasonClowrey @JasonClowrey 1 year ago Is Levels only available in the US? Reply @veronika8834 @veronika8834 1 year ago team retin A here! ❤ 1 Reply @4CarbideGaming @4CarbideGaming 1 year ago OMG how was i not subscribed to this. Reply @juanfernando4600 @juanfernando4600 1 month ago The Best procedure to stop ageing or reverse it is excercis, balanced diet, sleeping well, love others, taking vacaciones often, humor. Dot Reply @meimei2630 @meimei2630 1 year ago thank you!!!!! David Sinclair Reply @patrickday4206 @patrickday4206 1 year ago (edited) Lol did she try Melanotan when looking for skin peptides. You never know what might come up with that one. 🤣 Reply @sunmoon-84 @sunmoon-84 1 year ago My nails grow more quickly when I am on holidays. Reply @karma.420 @karma.420 1 year ago Anyone know why Athletic greens doesn’t contain vitamin D? 🤔 Reply @leadimentoobrien1221 @leadimentoobrien1221 1 year ago what about DENTAL HEALTH? dental plaque can get into the blood stream via bleeding gums etc Have you researched that? 1 Reply @jenxsj3902 @jenxsj3902 1 year ago Darling, good diet, exercise, sun-blocking, retinol, Botox and fillers. I look at least 15 years younger. 2 Reply @paulaarchuleta8684 @paulaarchuleta8684 1 year ago What about Coconut and Olive oil on skin? Reply @toniofficer525 @toniofficer525 1 year ago 63 skin going back in 1 second ! Reply @OrlandoAponte @OrlandoAponte 10 months ago My nails grow obnoxiously fast, so I guess that's good Reply @deliaocampo4340 @deliaocampo4340 1 year ago Also eating healthy active no worries not smoking good mindset serene🇸🇽🇺🇸 Reply @natashakramer4411 @natashakramer4411 1 year ago Where can I buy "one skin" cream? The one they talked about by Dr marryane Reply @ethancowart6765 @ethancowart6765 1 year ago (edited) i wanna hear david talk about some 5 amino 1mq .?? that activates sirtuins well Reply @052760kira @052760kira 1 year ago Nadia skincare have facial creams and serum with NAD. Is there any benefit to delivering NAD directly into skin? Reply @shilpymalhotra441 @shilpymalhotra441 1 year ago After how many hours of fasting does autophagy kick in? Reply @ip2925 @ip2925 1 year ago Couldn’t find anything on free sunscreen on beaches in Australia. Is this true? Reply @dhavaltalati7721 @dhavaltalati7721 1 year ago What is anticipated by oral use of Hyaluronic acid Reply @grunta101 @grunta101 1 year ago Thanks Doc😎😎 Reply @arkadifomintsev3679 @arkadifomintsev3679 7 months ago so calm and slow.... 5 min into the show and you still haven't said anything. ..I'll may use these videos as before sleep lillabys Reply @saulvillicana292 @saulvillicana292 10 months ago How does LED light therapy play out in all of these processes? 🤔 Reply @manuelojeda9144 @manuelojeda9144 1 year ago My rooster pecked my leg, cause he was hungry, and I'm already healed. Reply @andrewr76861 @andrewr76861 1 year ago Thoughts on intranasal NAD+? Reply @mitchtickets @mitchtickets 1 year ago (edited) The true secret to increasing lifespan is a sweet denim button down. 1 Reply @sketchur @sketchur 1 year ago How old are Dr. Sinclair's kids? When will they start looking older than him? lol Reply @mangos2125 @mangos2125 1 year ago Can you talk about the use of weed impact on aging? Reply @funtimes8296 @funtimes8296 1 year ago I missed the part where you're supposed to eat a tub of ice cream at midnight 2 Reply @MsYhuyhu @MsYhuyhu 7 months ago You made me laugh...with a cuting balls for men😅 Reply @leadimentoobrien1221 @leadimentoobrien1221 1 year ago I think VOLUNTEERING keeps you young too. Reply @sunmont1461 @sunmont1461 6 months ago 51...my skin went right back down Reply @jennifermccullough775 @jennifermccullough775 1 year ago O another question can you reverse ovaries that have been damaged by chemotherapy and tamoxifian Reply @AdisMoshi @AdisMoshi 1 year ago I have a question!!!!!! Do any of this anti-aging pills cause any harm to your stomach overtime!!!!!! Please let me know, I'm already taking vitamin d and k daily, and hair supplements. Reply @CallOfDutySniperzzz @CallOfDutySniperzzz 1 year ago I'd give this guy 38 max. He looks around 30 and even young looking for 30. Not 50 Reply @salsipuedes8425 @salsipuedes8425 1 year ago My mom is 48 and she still has her period it is normal ? Reply @rhythmofheaven1489 @rhythmofheaven1489 1 year ago He’s 53, but looks 33! Reply @ironmaidenfitness654 @ironmaidenfitness654 1 year ago I think eunuchs live longer because they don’t have children to stress them out! ☺️ Reply @jennifermccullough775 @jennifermccullough775 1 year ago I wish you could reverse osteoarthritis my fingers have changed the bone has relined itself 2 Reply @MitziHart @MitziHart 7 months ago Can anyone recommend a Resveratrol supplement,…specifically Organic💫 Reply @efivos5362 @efivos5362 1 year ago 46:38 Dr Sinclair, I have heard you many times claiming that it's 20% genetics and 80% epigenetics. Why is it different on this subject? Reply @DavidPaulNewtonScott @DavidPaulNewtonScott 1 year ago I keep putting this in comments but nobody has responded how about low level cyanide for killing senescent cells ie eating almonds. Surely they are weaker and likely to die. Reply @Wesker-bg1rn @Wesker-bg1rn 1 year ago cosmetic aging Suddenly david has a massive female following 😂 Reply @davidwest5177 @davidwest5177 1 year ago (edited) We don't have free sunscreen on the Sunshine Coast:-() also may I ask where you buy your Resveratrol... Reply @infora789 @infora789 1 year ago How to check and get rid of unhealthy metal toxins in the body? Reply @reverseaging5387 @reverseaging5387 1 year ago MX$49.00 Thanks! Reply @maryammihanyar8298 @maryammihanyar8298 1 year ago CA$2.00 Thanks! Reply @taraleightaracumming6726 @taraleightaracumming6726 1 year ago How do you feel about face lifts? Reply @1984schizosturm @1984schizosturm 1 year ago what types of laser work, the price span is huge, any tipps? Reply @jewelleryaddict @jewelleryaddict 1 year ago $50.00 Thanks! Reply @anakamhi7097 @anakamhi7097 1 year ago I’ve seen some mnm reviews where some women get their period back after menopause Reply @marinae7928 @marinae7928 1 year ago Actually it was pretty prevalent for women to have children over 40 post war in the UK before it became fashionable to bang on about it. Reply @mcgragor5042 @mcgragor5042 1 year ago (edited) Cr. Brad Stanfield just posted another video saying Resveratrol does not work, I really think you should respond to this. Just reading the comments people are questioning Dr. Sinclair's integrity. 2 Reply @sunnyelizabeth2910 @sunnyelizabeth2910 1 year ago What Reservatrol Supplement do you recommend? Reply @Maria-sz1fc @Maria-sz1fc 1 year ago It is seldom for the general public lets see the exemple of Mariana Boroni P14 cream: 50ml (which you can not use for your full body) >150$ Reply @kellyheather781 @kellyheather781 1 year ago My nails never grow they never grew even when I was little Reply @samiavirmani8912 @samiavirmani8912 1 year ago Can you please do a video on what you eat in a week? Reply @ilhan5515 @ilhan5515 1 year ago Any one here tried collagen for anti ageing? Or any of the other stuff here,. Reply @navya3481 @navya3481 1 year ago Does minoxidil work on women too? Reply @darkhorse7460 @darkhorse7460 1 year ago Collagen applied topically is ineffective as the molecule is too large to penetrate . 1 Reply @OZmast3r @OZmast3r 1 year ago proly a dumb question, but do cbd and or thc have any benefits/negative impacts? obviously smoking is not good but now we have edibles, vapes,oils and so on Reply @aaronward551 @aaronward551 1 year ago What I don't understand is that people who have never smoked never drank alcohol fit as a fiddle and drop dead of a heart attack or get cancer so I don't know why he's saying you can live up to say late 90s if you do what he says my advice enjoy life live life to the full eat a varied diet if you want a bit of cake have some only live once in this life. Reply @donstewart368 @donstewart368 9 months ago Stay of carbs, sugar, and grains and the sun wont damage you as much not to mention all the other benefits that come with it. Reply @godessofyouguess @godessofyouguess 8 months ago Thank you Reply @sarahroberts6413 @sarahroberts6413 7 months ago No, did not know what Botox was made of. I am a Black Woman Reply @snakeandturtleqigong @snakeandturtleqigong 6 months ago Thanks so much Reply @yemekkitabi @yemekkitabi 1 year ago (edited) Dr.Sinclair! I think alcohol and soda has aged you faster. How you didn't know it was bad. At university you've studied Alcohols. Reply @PaulManningg @PaulManningg 1 year ago Why is smoking bad? Is it the smoke coming in contact with skin? Is it the inhalation of chemicals? Is it the junk in cigarettes? Asking as an avid bong smoker. 1 Reply @jelena1659 @jelena1659 1 year ago Who got into menopause in late 30 or early 40?!!!! It's in 50s. Damn Reply @camiloandresleguizamon3624 @camiloandresleguizamon3624 1 year ago The best Reply @Coatch-monir @Coatch-monir 1 year ago ✨❤️ Reply @vincentsherlock6617 @vincentsherlock6617 1 year ago Just take Epithalon and a lot of hyaluronic acid. 1 Reply @nnnsss9438 @nnnsss9438 1 year ago Please, what is you explanation about Hunza Valley people in Pakistan, they live healthy up to 120 years??? Reply @daddyshoneygirlusa7030 @daddyshoneygirlusa7030 1 year ago As Dr. Sinclair is a total hottie, I am a believer. Something is working for him, it's worth trying! Reply @meinungabundance7696 @meinungabundance7696 8 months ago So, in CONCRETE terms what can we do NOW ? Wehen all these beautiful promises are not yet on the market? Reply @randaldurayhim3620 @randaldurayhim3620 10 months ago why women having childern older(30-40) is not as good as having them young(20-30)? can we change that? Reply @justinfuruness7954 @justinfuruness7954 1 year ago Please comment on the YouTube video discussing rasveritrol and debunking it, showing your huge conflict of interest, by multiple other esteemed scientists. Reply @maryammihanyar8298 @maryammihanyar8298 1 year ago CA$10.00 Thanks! Reply 1 reply @jadezee6316 @jadezee6316 1 year ago the best thing you can do for your skin is take vit c..........every 4 hours....8 grams a day is super.... Reply @AleksaDiaz @AleksaDiaz 1 year ago (edited) I think way more research and attention needs to be funneled into estrogen and progesterone. Even if combined therapy of progesterone and Estrogen has been commonplace for over a decade, maybe 2? Healthcare loves to leave out women and so many of the functional medicine thought leaders I follow are men, and many motivated primarily by their own mortality. It's fine, but women watch you and learn from you too. I think you absolutely should lecture on it, be transparent if there is not enough info then let that be known and push to keep funding it's research. I love to hear women being included, beyond reproduction as well.* I enjoyed this ep and your work David. 1 Reply @marisolcardona1038 @marisolcardona1038 1 year ago 🤔I wonder if we reverse aging will women body defer going into menopause until much later in life. Hmmm Reply @EinSofQuester @EinSofQuester 1 year ago The skin might be your body's largest organ, but it's not mine ;-) Reply @MisterFds @MisterFds 9 months ago The No Duh section is at 44:28, not 43:28. Reply @slfanta @slfanta 1 year ago Oh he looks like a college boy in this episode. Amazing,, 2 Reply @androidson4522 @androidson4522 1 year ago Use face skin piling cream. Reply @ciarog6116 @ciarog6116 1 year ago Does castration help animals live longer? My veterinarian told me no. Reply @JoaoVitorBRgomes @JoaoVitorBRgomes 1 year ago Regards from Brazil ! Reply @shoraimatyatya3040 @shoraimatyatya3040 9 months ago You are God sent can I please have your contact details. I. Would like to participate in your research Reply @betsywestbrook7169 @betsywestbrook7169 1 year ago So what type of sunscreen. I have see articles on the helioplex type of sunscreens that the metals migrate to the brain because they are nanoparticles. Is this true. Reply @user-qx3vv3lw1p @user-qx3vv3lw1p 1 year ago (edited) Wonderful information but the constant interruptions by the interviewer is making this incredibly difficult to follow. He can’t shot up for some reason Reply @peouspaul1258 @peouspaul1258 9 months ago (edited) Menopause is the beginning of iron overload.... Reply @raupatil874 @raupatil874 1 year ago I m watching this vdo from India,and would like to ask if this can help to cure FABRY DISEASED person....pl do reply.. Reply @Linda_Sci @Linda_Sci 1 year ago I love you guys, lol Reply @angiequintero2919 @angiequintero2919 1 year ago Thanks 🤍 Reply @rivkaruthgolan @rivkaruthgolan 1 year ago (edited) Age 64 4 seconds for skin to go back down Reply @anotheryoutuber2463 @anotheryoutuber2463 1 year ago this conversation is more toxic than the treatments discussed Reply @MsCaterific @MsCaterific 1 year ago 💚 Reply @urmetivask3997 @urmetivask3997 7 months ago you know all this stuff and you just recently gave up on alchol, cause you found out it's kinda bad for you, my mind is blown Reply @Lucifer-mq2du @Lucifer-mq2du 1 year ago In which year will the madicines will be completed that would extend my lifespan by hundreds of years?like how much time would it take more... I'm 13 and you better do it fast.,..plssss 1 Reply @jamiequigley5906 @jamiequigley5906 1 year ago The interviewer is painful to listen to. Great info from David as ever. 1 Reply @playframe6231 @playframe6231 1 year ago Please do one on teeth Reply @jonparrott4081 @jonparrott4081 2 months ago What about Dr. Boz (Dr Bozwoth) and her approach to also offering something like levels but also with insulin spike measuring .....??? Reply @INSU_INDU @INSU_INDU 1 year ago What about Dr Sinclair s hair.. is it natural or transplant/weaving done.. Reply @cv3796 @cv3796 1 year ago Thanks Mr. Burns doppelgänger! Release the hounds Reply @jenniferjenful @jenniferjenful 8 months ago Rhode Island has sunscreen dispensers at their beaches. Reply @carogibson7109 @carogibson7109 1 year ago 2 of 3 chance of death per child use to be Reply @shaystern2453 @shaystern2453 1 year ago never cared about cosmetic aging, but it's a great industry for folks wanting to get rich. who cares about wrinkles, gray hair? SO WHAT? 1 Reply @MultiGlobalnews @MultiGlobalnews 1 year ago Can you explain why our ears grow bigger as we she ..thanks x Reply 1 reply @yvonnesanders4308 @yvonnesanders4308 1 year ago Absolutely no woman in the UK will have any idea what their hormone levels are. 😂 it's bad enough trying to get hrt. But bless you for thinking of us. You realise we are 50% of the buying population? Reply @dystopiaseven @dystopiaseven 1 year ago ❤️❤️ 1 Reply @jshtaway1 @jshtaway1 1 year ago Is the sunscreen reef safe? How is that not your first question? Can’t live forever on a dead planet 🙄 Reply @sviniata @sviniata 5 months ago WHY THERE IS NO MORE CONTENT FOR AN YEAR ? Reply @josepho5055 @josepho5055 1 year ago (edited) At around time stamp 50:58 David says Retinol Cream .5%. Did he mean Retinol Cream .05% as I have look and do not locate Retinol Cream at .5% 2 Reply 2 replies @mowthpeece1 @mowthpeece1 1 year ago Um...pinch test ..pops right back down less than a second. I'm 58. Are you serious about many seconds? Dang, I'm gonna hate the hell outta that. Reply @DavidPaulNewtonScott @DavidPaulNewtonScott 1 year ago How many old movie stars were bald I have no idea they all wore hats. Wear a hat. Regarding grey hair what looks odd is the greying hair once it is all white you are going to look like Siim Land. Does he look old no. Basically you will just look Swedish. Reply @kambocolombia @kambocolombia 7 months ago trenbolone therapy is the best for alpha men Reply @orion10x10 @orion10x10 1 year ago My boi looking fly as hell in that jean jacket Reply @maryfuzzell6262 @maryfuzzell6262 1 year ago David S. seems very sincere; however like buying into fanatical religion I approach all of this with interest and selective caution. On collagen supplements or powders., You say it can't hurt but not proven. On nail growth you say it is an indicator of biological age. Since I've taken vital proteins in my coffee ( two scoops a day). my nails grow like crazy and are hard for the first time in my life. Am I biologically younger? That, I don t know.. but the collagen powder is doing the trick of giving me healthy nails and hopefully bone density . Reply @fernandoalmaguerIII @fernandoalmaguerIII 1 year ago So how do we reverse greys? 2 Reply 3 replies @milenabellotti9771 @milenabellotti9771 8 months ago …let them blow away in the wind… my new advice for mums Re their 20 year-old babies. Reply @reginaargentin2864 @reginaargentin2864 3 months ago menopause healthcare for women in this country is terrible. you have to go to a holistic doctor to get a real blood test that shows every level of everything. none of this is included in western medicine healthcare. they would prefer to hand you a traditional mare urine laced bs treatment for menopause. f that. I am in my sixties and I look decades younger. I did a lot of things counter to everything these guys are talking about when I was young like sun exposure etc but I don't eat processed food at all. I do yoga, meditation, and avoid chemical laden conventional skincare and all the traditional things people eat for convenience, eat chocolate everyday and avoid toxic people. I don't buy in to getting a bunch of shots like shingles etc. I don't wear sunscreen I use my own shea butter based cremes which is a natural sunscreen and still get the benefits of vitamin d. I developed my own skincare line without harmful industrial ingredients or cheap filler oils that are in most of them and the results speak for themselves. Reply @HORNGEN4 @HORNGEN4 1 year ago Have Dr. Charles Brenner on! Reply @firstlast5322 @firstlast5322 1 year ago ❤ Reply @052760kira @052760kira 1 year ago What about NAD creams? Reply @kellyheather781 @kellyheather781 1 year ago Why doesn't he look 20 1 Reply @jccp6362 @jccp6362 1 year ago Why don't they go straight to the point? 2 Reply @escorp991 @escorp991 1 year ago Botox looks great on you Dr Sinclair! 1 Reply @Jesus-xm5gv @Jesus-xm5gv 1 year ago (edited) At 52.38, what is the word he says that sounds like "UNIX"? He said "There have been studies that looked at ?UNIX? who don't have any testosterone and they live the longest. Reply @TotalyRandomUsername @TotalyRandomUsername 1 year ago No offence but does the on average longer live of castrates really have to be something biological? With less testosteron comes less risk taking and agressivity. Also i would bet on that those people do not get into hardworking jobs. And the most importand, they will not affected by the stress that women are causing for us. :) So this people are avoiding like a 1000 situations that makes a mens live shorter. Reply @TheNiveaman @TheNiveaman 1 year ago 57:11 - "What doesn't kill you mitochondria." - Patent that shid ^^ Reply @theneverendingjourneyoflif1482 @theneverendingjourneyoflif1482 1 year ago So often Matthew cuts David off! We want to hear it all. So stop it! SVP Reply @TraveltheWorldwithMatt @TraveltheWorldwithMatt 1 year ago This should be an interesting video Reply @shau-chiatam8535 @shau-chiatam8535 1 year ago What is the name of the Bio Clock testing company for a few dollars? Reply @veronicahuerta1790 @veronicahuerta1790 3 weeks ago someone knows what his opinion is about the COVID VACCINE Reply @elizabethk3238 @elizabethk3238 1 year ago What about FEMALE baldness! Reply @javieroliveras344 @javieroliveras344 1 year ago David I love you 💝😘 Reply @georgechristoforou991 @georgechristoforou991 6 months ago I thought it was about Cosmic aging? Reply @zbridgjpxupzm @zbridgjpxupzm 1 year ago 31:04 collagen powder manufacturing requires using a lot of chemicals. it is more harmful than beneficial... 2 Reply 1 reply @leothelittlesimba2682 @leothelittlesimba2682 1 year ago (edited) Please anyone summarize Reply @serpentdarkcloud5810 @serpentdarkcloud5810 5 months ago Will the poor have access to it in the future? Reply @summermoon4620 @summermoon4620 7 months ago What’s wrong to look your age ??? Who are we impressing the most important to be healthy and happy Reply @stevenunderwood2914 @stevenunderwood2914 1 year ago (edited) Australia - all beaches have free sunscreen???? What absolute nonsense. How can we trust anything Dr Sinclair says when he is willing to make such obviously false statements? I find Dr Sinclair's material super interesting, but after that comment, I'm starting to question whether or not his statements and claims regarding health are reliable. 1 Reply @123axel123 @123axel123 1 year ago Interesting but need to take advice from Huberman to make things more actionable. The tattooed guy seems quite full of himself having a different style in each sessions. His questions are probably written by Sinclair. Better if Sinclair just talks. Reply @leadimentoobrien1221 @leadimentoobrien1221 1 year ago what about marijuana in all its forms, does that affect anything? Reply @super_heroes @super_heroes 1 year ago 27:49 first David Sinclair meme Reply @susanhorton9492 @susanhorton9492 1 year ago rapamycin is by prescription only? Reply @suzanneharry5855 @suzanneharry5855 1 year ago So where are are these long living people to go where's the room on the planet ? What about meaning and purpose in life? 1 Reply @HigherThinkersClub @HigherThinkersClub 1 year ago 23:05. FREE SUNSCREEN ON AUSTRALIAN BEACHES = Death to The Great Coral Reef….Another subject I know- but really poor for fish and the eco of the water Reply @paukwinkyaw @paukwinkyaw 1 year ago Men can cut the ball and live long, what about ladies, David? Reply @JkBee @JkBee 1 year ago Perth doesn’t have the free sunscreen Reply @zotheprofessor100 @zotheprofessor100 1 year ago What about creatine Reply @ritascolaro4059 @ritascolaro4059 1 year ago When can we expect the pill? Reply @01123heavenlybe @01123heavenlybe 3 months ago If the original record always had a little bit of bumpf …. Reply @corporesano4437 @corporesano4437 1 year ago why don t u make it simple: chimichal analysis of youn blood vs old blood. and make the chimicals of young blood into old blood. tthat should be rejuvenate, right ?! Reply @i.ehrenfest349 @i.ehrenfest349 8 months ago I wonder if David dyes his hair. It does look dyed. Reply 2 replies @danielgeiger4619 @danielgeiger4619 1 year ago Where can I buy good high quality products? That I know are safe... Reply @miashay2524 @miashay2524 1 year ago Dr. Sinclair! You look like a teenager. What’s up with this. Reply @bulalaish @bulalaish 1 year ago So why should I believe what this apparently 25year old guy has to say about aging? Reply 1 reply @danthegypsy5871 @danthegypsy5871 1 year ago I know this doesn't pass the three sieves, but David Sinclair looks like a 50 year old mom trying to look hip with their daughters college friends coming over. Reply 1 reply @joeanna1100 @joeanna1100 1 year ago most the research seems to be mice related. not HUMAN 1 Reply @sharonmarsh3728 @sharonmarsh3728 4 months ago Talk more about Mythelization ? And Same-e Reply @delaneyondreams @delaneyondreams 1 year ago Can you give us a link to Dr. Cindy Missen (Messen?) Reply 1 reply @RedEyeification @RedEyeification 3 months ago You look a little bit like Dave Gahan from Depeche Mode... Reply @dcny69 @dcny69 1 year ago Feel better Reply @florinabelen7367 @florinabelen7367 11 months ago I want to join.David.i am 63 years old to have a younger look. Reply @cesarortuno4784 @cesarortuno4784 1 year ago I honestly come to this podcast to listen David Sinclair about the science and the studies but Matthew really annoys me speaking over David. Im love with this podcast but maann Mathew should just stick with asking the questions and being funny, pls let David talk on the science and the studies Reply @obmitty1 @obmitty1 1 year ago David looks weird,,,, forhead has dropped, eyebrows lifted…starting to look creepy not young 1 Reply @aniab-j526 @aniab-j526 1 year ago Thanks Reply @OckyAsFUCK @OckyAsFUCK 8 months ago Please make a video on why you are trying to monetize nmn ??? Reply @dechaisoul @dechaisoul 11 months ago Did not watch but came just to say the thumbnail reads as “REVERSE COWGIRL AGAIN” as it comes up with the others on my YT top page. Reply @orionbaden-powell1496 @orionbaden-powell1496 1 year ago everything is so male centric, if men went thru it, they would have fixed it by now Reply @nalimchik @nalimchik 1 year ago Also, David, I have something important to write to you, but I don't have your contact. I did let know Dr. Christina Sanchez about an 'important' thing I have to introduce. Reply @nadirnft9712 @nadirnft9712 1 year ago Yeah 👍🏼💪 Reply @m_c_d @m_c_d 1 year ago Insight Tracker - Essentially for the privileged.....that pricing👎 Reply @muslima2505 @muslima2505 3 weeks ago We evolved from apes 😂 … are we going to continue evolving? Reply @zv8035 @zv8035 1 year ago It seems he likes botox, at least from his eyesbrows :D Reply @Kanonka28 @Kanonka28 1 year ago Asbest is healthy. Reply @evalyn3975 @evalyn3975 1 year ago How old is this man 😐 Reply @ShelleySwyer @ShelleySwyer 1 year ago Lmfao these two 😜 Reply @johnzeuli5827 @johnzeuli5827 1 year ago Matthew doesn't look so healthy. Hmm. Reply @leeuwerikje @leeuwerikje 1 year ago Dr Brad Stanfield 103K abonnees Unfortunately, Dr David Sinclair has blocked me on Twitter, likely as a response to the Resveratrol controversy. pls, look at this short video that shows David Sinclair´s childishness. ´DR. DAVID SINCLAIR HAS BLOCKED ME´. Reply @adorableparakeets3608 @adorableparakeets3608 1 year ago So what are the takeaways n action items that we can do Reply @marilynowens4147 @marilynowens4147 1 year ago new sub Texas fan Reply @josepho5055 @josepho5055 1 year ago (edited) To David or who the person reviewing the posted comments. You have the trolls posting about investments along with contact information. Could you try to block clean up. There are where 17 postings about investing as of 9:30am on 02/09/2022 1 Reply @benchvirgin4243 @benchvirgin4243 1 year ago Where did you get that jean shirt at ? Reply @joannsmith3589 @joannsmith3589 1 year ago he clearly had botox because he hardly can open his left eye... droopy eye... Reply @AdonisGaming93 @AdonisGaming93 1 year ago ight boys.....when we getting our Lord Varys surgeries? Reply @ghstgrlwakeup @ghstgrlwakeup 1 year ago The sm7b is a wonderful mic but pleaaaaase put a de esser on your audio 😭😭 the S’s are driving me insaaaaneeee Reply @a.vaccarielli7637 @a.vaccarielli7637 1 year ago Answer the question short man.. are you the person who sold almost a billion dollars from GSK Reply @ModelJames13 @ModelJames13 2 months ago It's hopeless people. Give it up. Reply @craigcrawford6749 @craigcrawford6749 1 year ago Bet you a million bucks Sinclair doesn't see 80. Reply @emilyknowlton8602 @emilyknowlton8602 1 year ago Wish he'd stop saying POO POO. Reply @leadimentoobrien1221 @leadimentoobrien1221 1 year ago Pls research OXALATES Reply @ggwhhbb1822 @ggwhhbb1822 10 months ago my nail growths have slowed :-( Reply @IH8Sprinkles @IH8Sprinkles 1 year ago I this is sooo above my paygrade Reply @monicap7941 @monicap7941 1 year ago Very, very sketchy info on the menopause. You did not even mention the importance of using body identical hormones. Then when you talked about hair loss it was from a male perspective again. Women get thinning hair too, but the treatments are different. Just be honest and call the show MALE Lifespan. You're obviously not interested in women 1 Reply @cholakicha @cholakicha 1 year ago (edited) 01:06:00 Reply @mowthpeece1 @mowthpeece1 1 year ago Why would women want more estrogen when it's been implicated in sex organ cancers and blood clots? Reply @MarieMinton @MarieMinton 1 year ago Matthew please stop pointing at David with your pen Reply @AnaAna-rx3yz @AnaAna-rx3yz 11 months ago David, Did you inject Botox to yourself? Why you had to show by your hands, your forehead doesn't move up? :))) Great research and job though! ;) Reply @thomask837 @thomask837 1 year ago 52 yo. Went down immediately Reply @johnschnee3934 @johnschnee3934 1 year ago Salvation by grace through the LORD JESUS CHRIST Savior who died on a cross his blood has washed us clean of SINS WHEN YOU ask to be saved it is a free gift from GOD WE ARE SAVED BY FAITH NOT WORKS Reply @LuigiKjo @LuigiKjo 1 year ago Resveratrol doesn't work 1 Reply @leadimentoobrien1221 @leadimentoobrien1221 1 year ago cringe indeed. I bought the LIFESPAN book and do not remember the thumtack in the foot...... 1 Reply @brettarogers144 @brettarogers144 7 months ago Microneedling for HA? Reply @jbirdsong5413 @jbirdsong5413 1 year ago ? Is this just a very long commercial? Reply @elaineremains @elaineremains 1 year ago wtf?? naked mole rats are totally wrinkled!! 1 Reply @suzanneharry5855 @suzanneharry5855 1 year ago His face doesn't move , Botox??? Reply @lucybraun8969 @lucybraun8969 1 year ago Get to the damn title of the video! Reply @sandjvj911 @sandjvj911 1 year ago This guy straight up copied Andrew huberman channel intro 🤡👍 Reply @renatopires3015 @renatopires3015 1 year ago The dude interviewing David talks too much. David opinion is the subject here, not him. Reply @tonymaldonado @tonymaldonado 8 months ago nice shirt David Reply @levisinner2694 @levisinner2694 1 year ago He's great but I can't stand his monotone. Had to listen to parts of this podcast several times to pay attention to what he says Reply @lightwarrior432 @lightwarrior432 1 year ago Women should STAY AWAY from Estrogen. Reply @petereriksson6760 @petereriksson6760 8 months ago How can you first hype up NMN as a supplement and then go ahead and take it off the market in order to profit from it? I am sorry Dr Sinclair, I believed in you but you lost all credibility now... sad... Reply @dollardun5868 @dollardun5868 8 months ago I wish your partner talked less, and quit asking questions. Anyone that knows you, knows more than this man. I finally just gave up. You don’t need help. Reply @AnGel-vl3df @AnGel-vl3df 1 year ago We were never apes or gorillas btw…. Do people still believe that? Reply @rolfjacobson833 @rolfjacobson833 1 year ago thank again David Sinclair Reply @susanross5758 @susanross5758 1 year ago Is Inside tracker in canada Reply @omerb.5845 @omerb.5845 1 year ago HE LOOKS YOUNG BECAUSE HE İS GAY:)))) Reply @stephenbrown2054 @stephenbrown2054 1 year ago Why keep promoting Resveratrol when multiple studies have disproven it. Is it because of million dollar patents. ? Reply @paulsansonetti7410 @paulsansonetti7410 1 year ago Albert Einstein was an incredible plagiarist btw Reply @schrodingerbracat2927 @schrodingerbracat2927 1 year ago botox is bollocks Reply @jamesfrith9869 @jamesfrith9869 1 year ago For the Alg boost Reply @Claudia-so7qz @Claudia-so7qz 8 months ago hydrogen gas! Reply @osea5000 @osea5000 1 year ago 29:05 Reply @DonnaHolbrook-pb8zg @DonnaHolbrook-pb8zg 2 days ago Change background to a dark color Reply @heidiroy-kerckhoff1527 @heidiroy-kerckhoff1527 7 months ago I know how to reverse it..save up about 18 grand and go get cosmetic surgery from a conservative surgeon Reply @whatthefunction9140 @whatthefunction9140 1 year ago Why should I listen to this teenager 🤔 Reply @jaqueitch @jaqueitch 1 year ago Sinclair looks very creepy. What is going on? 2 Reply 3 replies @chickensandw1tch @chickensandw1tch 1 year ago 8:32 lol Reply @stephiegetsit @stephiegetsit 1 year ago Cindy who can you post her link Reply @kimberlyfoster2112 @kimberlyfoster2112 1 year ago David are you using Botox Reply @bonochibear7895 @bonochibear7895 1 year ago Yes don’t poo poo it Reply @thatchessguy7072 @thatchessguy7072 1 year ago I got the 1000ths like on the dot! 1 Reply @Guest_1138 @Guest_1138 1 year ago Co-host? Reply @jungletheme2094 @jungletheme2094 1 year ago I dunno about the jean jacket ay Reply @burttheman3697 @burttheman3697 1 year ago Botox! Reply @333Paradigm333 @333Paradigm333 1 year ago Science will never be able to give eternal life. Eternal life is only found Jesus Christ the creator of all things. To receive that eternal life, you must admit that you are a sinner before God, believe that Jesus died for your sins (as a substitutionary atonement) then call upon the Lord Jesus Christ and you shall be saved from hell, to an eternal life with the creator. Please don't go to hell, it is completely avoidable, but requires that you to make a decision. Reply @tonybrawley6621 @tonybrawley6621 1 year ago DMAE??? Reply @davidsneverwin4491 @davidsneverwin4491 1 year ago Stuffy David Reply @denahom @denahom 10 months ago (edited) Elron…. Reply @itsbung @itsbung 1 year ago 2 Reply @itsbung @itsbung 1 year ago 2 Reply @magdanormington2543 @magdanormington2543 1 year ago 11 Reply @sharkymoon422 @sharkymoon422 7 months ago Stopped at 27 minutes because there isn’t any scientific evidence that the sun causes skin cancer Reply @johnfloryan8535 @johnfloryan8535 7 months ago No useful information was presented. Reply @georgem2742 @georgem2742 5 months ago 1.Can the interviewer speak less? 2. Can he stop interrupting. He keeps disrupting David's thoughts. It's highly irritating Reply @dankahraman354 @dankahraman354 7 months ago Dr. Sinclair I have unsubscribed from your channel. You should know why......you have a conflict of interest to the detriment of the rest of us. Reply @mihailzapryanov286 @mihailzapryanov286 1 year ago Someone should tell the interviewer just to stop talking!!! Reply 1 reply @kianadavenport474 @kianadavenport474 1 year ago I can't watch this. Plante is so damned distracting. Awful loud, nasal voice! Go away! Reply @01123heavenlybe @01123heavenlybe 3 months ago Testim…..out Reply @mrjonjoe1895 @mrjonjoe1895 8 months ago What a weird soy boy statement, "instead of lecturing on body parts we don't have" ???? What are you talking about, what do you think women posses that is out of the knowledge of men, aren't you a science podcast? I can't take that dude seriously. Reply @LindaRWard @LindaRWard 7 months ago This other man talks too much. Please let the doctor go on with his ideas. Reply @kostaspataridis @kostaspataridis 5 months ago Don’t point with that stupid pen. 1 Reply 1 reply @adelchidipalma9857 @adelchidipalma9857 1 year ago why he is wearing the stupid hat, why slow down the ages of eveil mankind? Reply @chadhill8776 @chadhill8776 1 year ago Thanks for the bait and switch talking about menopause instead of your stated topic. Blah, blah, blah. I’m out of here. Reply #7 Lifespan with Dr. David Sinclair The Science of Keeping the Brain Healthy | David Sinclair 331,615 views Feb 16, 2022 Podcast Episodes In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep. #DavidSinclair #Longevity #BrainHealth Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Levels - https://levels.link/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Lifespan podcast website: https://www.lifespanpodcast.com Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsincla... Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclai... Stay up to date with David's work to democratize biological age testing and insights: https://www.tallyhealth.com Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante Timestamps: 00:00:00 Introducing Episode Seven: Aging of the Brain 00:04:39 Thanking the Sponsors 00:07:38 Ex-differentiation as a Driver of Aging 00:09:22 The Brain Ages Slowly 00:14:17 Cognitive Function and Plasticity 00:17:44 Three Longevity Pathways: mTOR, AMPK, and Sirtuins 00:23:26 Plant-based Diets and B-vitamins 00:28:32 Homocysteine, Plaque, and Vasculature 00:32:35 Fatty Acids 00:35:48 Physical Activity 00:39:14 Metformin 00:46:02 NAD Boosters 00:50:33 Increasing Blood Flow 00:53:20 Sleep 00:58:02 Overall Message: Keep your Brain Healthy 00:58:50 Next Week’s Episode and the Future of Medicine 01:01:21 Options for Subscription for Support Links: The cerebellum in the brain ages slowly: https://bit.ly/3JC9CLL Neuronal cells have a lower epigenetic age: https://bit.ly/3HVZsVA Sirt1 regulates aging in mice: https://bit.ly/3sGZPNC Mediterranean diet and brain health: https://bit.ly/3uUpYuL Mediterranean diet and dementia risk: https://bit.ly/34Igp7H Aerobic exercise improves executive functioning: https://bit.ly/34Dv5oJ Exercise and mouse models of neurodegenerative disease: https://bit.ly/3516IRn Strength exercises elevate the expression of BDNF: https://bit.ly/3GTLqCs Metformin enhances cognitive ability in fish: https://bit.ly/3sLtWn2 Alzheimer’s disease and metformin: https://bit.ly/3GSdTJ5 Metformin use correlates with a reduced risk of dementia: https://bit.ly/3GT0KPO NAD boosting and Alzheimer’s disease: https://bit.ly/367C2P2 ALS, nicotinamide riboside, and pterostilbene: https://bit.ly/3Bm2VKN Vascular aging and NAD in mice: https://bit.ly/34Uemgx In mice, overexpressing Sirt1 in the brain extends lifespan: https://bit.ly/3HNRyh3 Sirt1 ameliorates amyotrophic lateral sclerosis in mice: https://bit.ly/3LvUWiO Sirt1 protects against Alzheimer’s disease in mice: https://bit.ly/34KZXUe Sirt1 and neuroprotection in a mouse model of Huntington’s disease: https://bit.ly/3BqymDJ Sleep loss reduces lifespan in flies: https://bit.ly/3Jt6BgA A single night of sleep deprivation increases amyloid-beta: https://bit.ly/3uSNGaU All-cause mortality correlates with sleep duration: https://bit.ly/3rQl14f Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. Chapters View all Explore the podcast 8 episodes Podcast Episodes David Sinclair Podcasts David Sinclair 299K subscribers Videos About 771 Comments rongmaw lin Add a comment... @Jmartestuesday @Jmartestuesday 9 months ago It is 7:30 PM here at my house. I was listening to your discussion about aging till you got to the part about the need for exorcise. I stopped the You Tube video and got off the comfortable office chair and went for a 2 mile walk. I dont particularly enjoy walking. I do enjoy being ABLE to walk. I'm 91 and am interested in being able to walk and to think properly. Your talks on You Tube are a blessing to me, thanks. 81 Reply @j2.a.m.pthomas121 @j2.a.m.pthomas121 1 year ago I don’t typically comment, but wanted to confirm that I appreciate Matt’s role (cohost) in this podcast. He tends to ask the very questions I have as a listener. 342 Reply 9 replies @19Jetta @19Jetta 1 year ago I know I say it almost every week, but thank you again for doing this podcast. I am aware it takes your time and effort and no doubt you have lots of other things you could be doing. This is just an incredible resource! 197 Reply 3 replies @SheilaBella @SheilaBella 1 year ago What a great episode! Thank you both! I have to agree with the others who commented that MATT’s role in this is KEY! I never comment but I just had to say how I have an easier time learning this stuff because of his participation. 51 Reply 2 replies @mitchtickets @mitchtickets 1 year ago Main takeaway, "Without a functioning brain, we are really quite useless." -Dr. David Sinclair. 128 Reply 2 replies @SirGolfalot- @SirGolfalot- 1 year ago (edited) Dr. Sinclairs' videos are an inspiration. I was exercising, fasting, eating right, and taking supplements until the spring of 2020. Time to get focused on longevity once again. 19 Reply 1 reply @paigewalker2077 @paigewalker2077 1 year ago This episode was the one that finally got me to share this with my parents- the others were super inspiring to me, but not enough to make me feel like my elderly parents might actually take action. "The Average onset of dementia is 80 years old" - this episode made me feel like I'm doing a disservice NOT to share this with my parents! Thank you for making this info available to the masses! 9 Reply 1 reply @HardForking @HardForking 1 year ago The best podcast I've found. You guys are fantastic, please keep this going. I've followed David's works for a number of years and put him right up there as one of the best humans we have on this planet. 23 Reply @zebragiraffe1 @zebragiraffe1 1 year ago (edited) I work with many elderly people in their 80s and 90s, and most of them are not overweight, can still walk short distances and many use their smart phones to stream into their hearing aids or use the app to control the hearing aid volume and programs. They are inspiring. 6 Reply @sciencensorcery @sciencensorcery 1 year ago Folic acid is not B-12. It's the synthetic form of folate, which is B-9. Many people are unable to properly utilize folic acid and need to take folate — but some people also need that folate to be pre-methylated. And others can react poorly to methylated folate (I experienced this myself a few months ago and the effect was staggering). It's a bit complex but worth looking into before you supplement (or if you start and don't take to it well) so you know which form you need! 143 Reply 27 replies @cecipalacios1007 @cecipalacios1007 1 year ago Great podcast! As a 68 years old my focus in healthy aging! Thus, I completely agree with Dr Sinclair said that we need to take care of our brain not only for us but for our family as well. 38 Reply 1 reply @valjohnson5835 @valjohnson5835 4 months ago I listened to all of your episodes on the Podcast App. within days. The content is interesting and informative. Both co host are amazing and thought provoking. Love you both! I really appreciate the way Dr. Sinclair explains the science behind everything and the way Matt asks questions or presents information. This is the best duo I have come across. Please continue to do more episodes. I have learned so much and you have inspired me to make some meaningful changes in my life. Thank you! Reply @jeanashchuchinov6593 @jeanashchuchinov6593 1 year ago I love your podcast, I can’t get enough. I was happy to hear you are going to have a season two lol 30 Reply 1 reply @pops4457 @pops4457 1 year ago I feel so blessed to have found this podcast at 24, thank you both tremendously🤟🏻 45 Reply 3 replies @ljacobs5478 @ljacobs5478 1 year ago Great video! I’d love to hear about ADHD in your next season! 5 Reply @shelleyhuskey1870 @shelleyhuskey1870 1 year ago David you are a special person! Thanks for everything you do. I have learned so much from you and your books. 8 Reply @mhelsher1 @mhelsher1 1 year ago (edited) I love this casual, engaged and authentic conversation. I'm more a creative writer/philosopher than a scientist. But I thank god for good scientists like these two. I think we're coming into a better age -- the age of conversation (which has always been my greatest teacher), wherein the sound bite media slowly, and quite painfully, dies. 5 Reply @janeca10 @janeca10 1 year ago Special thanks to Dr. Sinclair for delivering true science to our homes. I love neuroscience, so this is a fantastic episode!I Also would like to comment that the conversation format is great. Matt does a really good job. Tks everyone that makes this happen. 6 Reply @stephenyoung3550 @stephenyoung3550 1 year ago As an extremely busy professional and getting a little older, I enjoy learning about avenues that could help keep me optimizing my overall function/performance. Great podcast and the 2 hosts work really well together. 5 Reply 1 reply @aceofhearts158 @aceofhearts158 1 year ago Thank you for making this podcast. If you guys continue with the podcast, I would greatly appreciate further elaboration on this topic. I am only 29, but my brain has deep white matter lesions, which are very uncommon at my age, but very common in the elderly. If you guys could explore the research on this topic, it would be greatly appreciated. I've been looking into as many papers as i can find on the topic, but I don't have the same access to the journals that you have. Thank you 1 Reply @sunshinecitypersonaltraini7228 @sunshinecitypersonaltraini7228 1 year ago Really enjoying the progression of these, excited for the next episode! 23 Reply @annewilliams9279 @annewilliams9279 1 year ago People like David Sinclair, Aubrey de Grey, Jason Fung, Liz Parrish makes me honestly believe that we can say goodbye to pathetic diseases once and for all. For the last few months, I've been taking one tablet each day of NMN-Vitruvin Health supplement. I'm astounded to discover that my metabolism now functions as well as it did when I was a younger. Other outcomes aren't nearly as visible yet, but I saw a significant boost in energy and concentration. I'm going to order another few rounds from their website. It took around just 3-4 days to see a difference. 😇 Reply @sandrathomas6216 @sandrathomas6216 1 year ago I was extremely impressed by this podcast. I learned a great deal of new things. I would love for you to follow up another podcast series. Reply @michaeltegler157 @michaeltegler157 1 year ago David and team, Thank you for the continued commitment to optimizing life. A discussion on the Microbiome would be tremendous as I have struggled with GI issues (IBS-C) and believe I have been suffering with invasive candidiasis as I have recently taken fluconasole which provided relief not only in my stomach but also caused the pain and stiffness to go away from joints, back, shoulder, etc. I am 49 yrs old and have taken many antibiotics throughout my life predominantly for sinus related issues which may have caused this condition of excessive candidiasis in my body and am curious to know if there is a way to restore the microbiome and healthy bacteria to optimal levels without Fecal Matter Transplantation as this is not readily available in the US. I'd also be inclined to go away to a clinic of sorts for 30 days if you know of one that would provide the structure and support to restore the microbiome. Thanks again for all of your dedication and work! 8 Reply 7 replies @t.j.robertson9565 @t.j.robertson9565 1 year ago I look forward to watching these podcasts. Thank you for sharing your life’s work 💙 Reply @claudettesechler149 @claudettesechler149 1 year ago Just look forward to your podcast..it is so innovating and love hearing about the wonderful things about the health field that I can apply to myself! Just wish I could have dinner earlier instead of later but it is a special time to enjoy a great meal, glass of wine with my hubby and chit chat, laugh, listen to great music..that’s a great health fix for me!! 4 Reply @whiteninja9481 @whiteninja9481 1 year ago For once, a decent host who asks decent questions. Well, THAT is a change. Excellent program and well-worth the time viewing. 1 Reply @andrewfeuerstein2597 @andrewfeuerstein2597 1 year ago Incredible information and I absolutely love the tandem here. You have my vote for WAY MORE CONTENT WAY MORE. You and Andrew Hibernian need WAY MORE CONTENT. I literally listened to all of your videos and his in less than 3 days. Can’t get enough Reply @dannycashman8446 @dannycashman8446 7 months ago I work permanent night shift, but am also health seeking and actively training / exercising regularly (3 gym sessions & between 7-10 miles walking 5 times a week). I sleep on average 7.5 hours during the day. Blood work is all ok over the last year. looking forward to checking by biological age to see what the night shift is doing in terms of aging. I love if more studies were done on someone like myself to see the long term effects of night shift work is mitigated by other health seeking behaviours. Thanks for the podcast I've enjoyed the series a lot. Reply @vickydaisy1905 @vickydaisy1905 1 year ago Love both of you and your podcast. Thank you for making it happens. 1 Reply @qski1 @qski1 1 year ago Looking forward to the next season, please continue! I would be interested the most in the effect of excercise (various types/cardio/weights) on aging. Reply 1 reply @ChannelJtotheD @ChannelJtotheD 1 year ago Amazing podcast. Yes, I’m enjoying listening to all of your videos and at the same time gaining so much knowledge with coping with longevity n living a healthy and productive life. Thank you immensely. 1 Reply 1 reply @sionnach013 @sionnach013 1 year ago That was a brilliant podcast , David . So interesting . Keep up your good work , well done . Reply @LCarefortheworld @LCarefortheworld 1 year ago Thank you for doing the podcast! Feeling lucky I get these incredible information from the source I can trust! 1 Reply @jonahalldors5488 @jonahalldors5488 1 year ago Love your episodes! such a great information you are sharing. Reply @Kristif815 @Kristif815 7 months ago Is there going to be a season two? I'm enjoying the great content. Reply @plantbasedathleterealtor6145 @plantbasedathleterealtor6145 1 year ago Excellent! I’m grateful for your podcasts 💫🙏🏻 Reply @dkollaritsch @dkollaritsch 1 year ago yes..please keep going with this podcast! It is so very important for us all. 2 Reply @patriciasozalac.4133 @patriciasozalac.4133 1 year ago I just love this podcast. Thank you for sharing all this information! 5 Reply @seokoes @seokoes 1 year ago one of the few person on youtube that i deeply respect , thanks David for all of fantastic work and sharing to public. 6 Reply @francestorreysirdevan4774 @francestorreysirdevan4774 1 year ago Best podcast ever. Love and appreciate the work you both and your team do and share. Thank you all!! A question about fasting for David: what do you prescribe for your children? Is one meal a day your recommendation to anyone of any age? If not, what age do you recommend starting that protocol? Additionally, I wanted to share that algae oil is a perfect vegan EPA/DHA source/supplement that circumvents the fish oil route. In fact, it’s what the omega 3 rich fish consume too! Highly recommended! 3 Reply @calvinscott9110 @calvinscott9110 1 year ago Thank you guys so much for doing what you do! It’s really mind opening learning from you Mr. Sinclair. I have one question that you may be able to shed some light on. Is any kind of intermittent fasting acceptable if one is missing their gallbladder? 1 Reply @mjoneill3577 @mjoneill3577 1 year ago Find your podcast so informative. Can you list the supplements that a plant-based eater would need to take. I do take B12 and D but wondered what else I need to take Reply @Mum2cuties @Mum2cuties 1 year ago (edited) I’m an optometrist and I’m glad you emphasised the importance of an eye examination to assess general vascular health. 3 Reply 1 reply @bestrongandloveyourself2370 @bestrongandloveyourself2370 1 year ago I just got my first Inside Tracker Inner Age test results and I am 10 years younger than my chronological age! It made me so happy! 😁 I hope that if I follow Inside Tracker recommendations and advices given on this podcast I will be able to become even younger! 😊 Thank you for the information that you are sharing! 🙏🥰 1 Reply @georgerodriguez7594 @georgerodriguez7594 1 year ago Thanks for doing this podcast. Very good information, live changing. Reply @Amyloushetty @Amyloushetty 1 year ago Best podcast / YT! So glad this channel was created it really easy to follow and so much valuable information. X 2 Reply @drchristianthoma7704 @drchristianthoma7704 1 year ago Thank you David and Mathew for an excellent series. Apologies if this was corrected later in the podcast, I didn't want to forget posting this. There is a slight error earlier on - vitamin B12 refers to the cobalamins not to folic acid. B12 is found only in animal products and faecal matter contaminated vegetables. There is some synthesis by bacteria in the large bowel, and some evidence of absorption, although I'm not aware of this being quantified. Folic acid is the term for synthetic folate, which is distinct from naturally occurring folates. Folic acid is in an oxidised form and needs to be converted to be biologically active, whereas natural folates in food are in their oxidised form. Folate, sometimes referred to vitamin B9, but not frequently, is mostly found in plants, although liver, being the storage organ, is also a viable source. I look forward to listening to the rest of the podcast. Reply @murrmurr765 @murrmurr765 1 year ago (edited) Exceptionally episode as always. You really complement each other well! Reply @Hero0fTimeSS @Hero0fTimeSS 1 year ago I've been listening to you and am amazed at all research and trials that you have been conducting for the benefit of mankind. Sitting here in India I am able to get the information that I would never have access to. Thank you for all your talks. My question to you is, I have been doing intermittent fasting and loving it. I did it for a month with great results, high energy levels. However I was taking no supplements. I am again on intermittent fasting for the past one month. Two meals a day and I have just been diagnosed with a vit B deficiency. I have started on a vit B supplement. Do you have any suggestions on what I should do. Thanks. Looking forward to hearing from you. 2 Reply 1 reply @gg86able @gg86able 1 year ago Probably going to need to watch these 100 more times 🤯 Thank you for making these videos 🥰🙏 1 Reply @CelluloidBlonde @CelluloidBlonde 1 year ago I have enjoyed your series very much. Thank you for the information. I would like to hear more about peptides if you do future podcasts. 1 Reply @valeriehopebennett @valeriehopebennett 1 year ago thanks to DR SINCLAIR AND MATT FOR SUCH HEALING ADVANCED INFORMATION WHICH WE ALL NEED FOR SELF EDUCATION ON IMPROVING OUR HEALTH AND LIVES. Reply @mvc9871 @mvc9871 1 year ago I see that David Sinclair has posted a video and come directly to give it a like, even before I watch it.That is how good everything he does is. Thank you sir. 1 Reply @brendaspalding867 @brendaspalding867 1 year ago David I’ve seen you on Joe Rogan’s podcast. You’re one my favorite guest. I’m so happy that you’re doing your own podcast. I love Joe but I love him more when he has people like you on. I’m a fan. I hope you keep it going. Reply @michelem226 @michelem226 1 year ago (edited) I've been vegan for 20+ years. B12, not folate is definitely the most important to supplement with for brain health on a vegan diet. Permanent damage to the nervous system can happen with prolonged deficiency. For Omega-3s, the recommendation is 1 Tablespoon ground flaxseed per day or to take algae-based supplement for vegans. The algae-based supplements are expensive but more reliable than flaxseed. 17 Reply 8 replies @perkyzombie @perkyzombie 1 year ago Thank-you so much for sharing all this research, for myself it has not fallen upon deft ears. I love rigorous science and all it's intricacies. God bless. Reply @felixsosa3949 @felixsosa3949 1 year ago Something I've been wanting David to take a shot at answering: what is (roughly) the appropriate age to begin with some of these interventions? For example, should I start taking supplements (NMN, Resveratrol) at 30? Late 20s? Late 30s? Or should all of these questions be determined by blood tests? 3 Reply 1 reply @bigbitsmama4802 @bigbitsmama4802 6 months ago Fascinating! I am listening here for my whole family, I'm going to do what I can to help everyone learn & thrive. My 80 year old mom was just taken off metformin and put on insulin. I was So disappointed. I think I'm going to go with her to her next doctor's appointment. tot tot Reply @MrFreerideForever @MrFreerideForever 1 year ago Thanks for your work Dave. Isn't it insane that more people haven't gotten to work on our biggest prob? Our worst disease? Like why hasn't Elon started an anti-aging company? The way he misses milestone predictions he might wanna extend his life a good bit so he can actually see FSD & Mars happen. 😐 1 Reply 1 reply @williamnunn8847 @williamnunn8847 1 year ago thank you david for the advice on NMN. I am going to get on this quick, as i have chronic insomnia at the moment, from mental health. i exercise with HIIT and calisthenics. i take zinc, vitamin d and ashwaghanda but realise this is not enough at the moment. 1 Reply @stephenlucier @stephenlucier 1 year ago This is amazingly informative, please don’t stop at 8! 17 Reply @jeanninemurphy8071 @jeanninemurphy8071 1 year ago Thank you for your brilliant work! Reply @palden4579 @palden4579 1 year ago I am 58. Most of my years, after my 'teenage slim time', I was about 10 pound overweight. Around at 45 I developed some knee pain for many years and like so many of my pals, I thought it is just the body worn out because of the hard work as a nurse. So, it is just normal life...! But then I discovered the Ketogenic diet, and after 2-3 weeks my knee pain was gone and never come back. I almost never experience ANY pain at all in my body. If I tell this to my oldest sister, 62, that she should stop eating sugar and do low carb eating, she screams at me: "My body, and knees are worn out, nothing can bring it back!!". She just don't believe me, that the sugar and carbs is the ONE who give the inflamation and the pain, AND it is reversable! It's sad, that almost no one knows, that with eating low carb and no sugar, all the inflamation will be gone and one will feel normal again!! It should be called out from the Rooftop! 29 Reply 12 replies @omittapir5986 @omittapir5986 1 year ago Great episode Dr Sinclair and Matt. Please start new podcasts pronto.! ☺ Reply @loudboomboom @loudboomboom 1 year ago Thank you guys so much for this invaluable information. Reply @ceories @ceories 1 year ago (edited) Hi David, want to thank you for what you are doing for humanity's answer to longevity and a healthy lifestyle. I am thinking about taking a NR supplement and wanted to know which particular ones you recommend? I was looking at the NAD+ supplement by a company called: TRU NIAGEN. Also im gonna start following the mediterranean and okinaowen diet. One more thing regarding wine: How much red wine (Malbec/Petite Syrah) shall i drink per day before the alcohol becomes a negative effect?? Reply @dudaregister @dudaregister 1 year ago I hope this podcast becomes a perfect example of the cart leading the horse. If people are primed to expect research and results, I think they're more likely to advocate for it. All of these happy futures can only be achieved if we fund them. And funding is driven by interest. Reply @quarantees8736 @quarantees8736 1 year ago Fantastic episode again guys, thank you 😊 3 Reply @earvinealyssciencetechnolo8909 @earvinealyssciencetechnolo8909 1 year ago Thank you Dr. Sinclair for this information. All of your work is interesting but this reverse aging gene therapy is truly awesome. I am a huge fan. I saw your research on regrowing the optical nerve. I am legally blind due to my optic nerve being injured. Me and several blind people I know are very interested in your research. Is there any way we could do some type of phone interview for my youtube channel. I know you are super busy. We watch all of your interviews, but would love more information on how your research could help the blind. Reply @raheemh.9891 @raheemh.9891 11 months ago I am so glad finding you and following you. By the way i am 52 with diabetic . I am learning a lot. Thanks so much. Reply @olgawillemsen5238 @olgawillemsen5238 1 year ago I found fascinating the fact and the explanation for the brain aging slower than the rest of the body. Isn’t it the reason why when we age we keep feeling young inside??? Reply @Articulate99 @Articulate99 1 year ago Always informative, thank you. Reply @andyatmosphere @andyatmosphere 6 months ago Excersise has been proven to be one of the best overall health benefits. Not sure why this isn't talked about more. Reply @megalo9999 @megalo9999 5 months ago Nicotinic acid (flush niacin) modulates all 3 of the pathways discussed in this podcast through the GRP109a pathway: mTOR, AMPK, and SIRT1-7. There are an ample amount of studies available. Reply @Viva-Persia @Viva-Persia 1 year ago I just subscribed to Dr S. channel.. having followed his lectures in the past .. thank you for the awesome stuff.. Reply @dottiepolly8564 @dottiepolly8564 1 year ago Keep up the good work Mr Sinclair 👍👍👍👍👍👍 4 Reply @jessicabennett5058 @jessicabennett5058 1 year ago Love these podcasts! Two questions. I see several pts with elevated B12, is this of concern or does it indicate anything? Also, is there a list of recommended targeted levels of each vitamin we should reach to have optimal levels not just ones in the “normal” range? Thank you! Reply @Sk0lzky @Sk0lzky 1 year ago Resveratrol can also be found in red wine vinegar and balsamic vinegar so if you can't afford supplements and don't drink alcohol give it a try! Posca is a very refreshing drink, and surprisingly tasty once you get past the initial acidic hit (aroma more than anything, it's actually not very sour for some reason. Tastes like weird, fruity mead) 6 Reply 2 replies @AnnTsungMD @AnnTsungMD 9 months ago Great episode. Thanks for this! Reply @Mohandas.Gandhi @Mohandas.Gandhi 1 year ago "Today we'll be talking about the most important organ in the body, the brain." -David's Brain 62 Reply 2 replies @jeanpollack5102 @jeanpollack5102 1 month ago I love the interaction between dr. Sinclair and Matt Reply @marides1479 @marides1479 1 year ago Watch out with B6! I live in the Netherlands where they tested different brands of multivitamins. Although it showed 100 % of the daily recommended dose some did contain much more causing numbness in the tooth and fingers. B12 can also be obtained from spirulina and seaweed you do not have to consume meat 1 Reply @melissashare7543 @melissashare7543 1 year ago This podcast provides so much beneficial information to help reverse aging with easily accessible protocols and regimens. Fisetin is one supplement that has not been discussed yet and I am interested in knowing if you think that it may be beneficial for reversing age or age related degeneration? I know that the Mayo Clinic is currently running studies on this presently and I am interested in possibly adding this to my regimen. I would appreciate your thoughts on if it may be effective and if it is safe for humans to consume? Thank You for sharing your knowledge! 5 Reply @jeanclaudecharles9398 @jeanclaudecharles9398 1 year ago Thanks a lot for these informations I can use to better myself, and for this huge service you're doing for humanity. You're a GOD inspired Soul. 2 Reply @Tiernansteatime @Tiernansteatime 1 year ago Great podcast, you two definitely need to stay together. You play off each other perfectly 5 Reply 1 reply @Inconceivable-pb5hc @Inconceivable-pb5hc 1 year ago You gotta reach out to YouTube so they can recommend this video virally to spread this priceless information Reply @plantbasedathleterealtor6145 @plantbasedathleterealtor6145 1 year ago Thank you so much for a great podcast! Please make one about HLAB27 positive 💫🙏🏻 Reply @rolfjacobson833 @rolfjacobson833 1 year ago Thank David. Your series has been incredible. Are you on Patreon? i will support your channel more 4 Reply @Aman.Akshay.Sharma @Aman.Akshay.Sharma 1 year ago What do we know about lifestyle protocols not related to diet/sleep and how they age the brain? For example reading, spaced repetition, music, cognitive training, new experiences etc? Andrew Huberman’s episode on how play impacts plasticity was really interesting, so I’m curious how this all ties into ageing. 13 Reply 1 reply @sandrakillalea1150 @sandrakillalea1150 1 year ago This is an Excellent episode; they all are. Thank you for the part of you, you both, that is altruism. 2 Reply @MrBrianDuga @MrBrianDuga 11 months ago Great episode. As others have mentioned, he calls folic acid and B12 the same thing. Feel free to correct me... B12 is either Methylcobalamin, Adenosylcobalamin, Hydroxocobalamin, Cyanocobalamin. They all play different roles and a good source is Liver. Cyanocobalamin is in cheap supplements and the cyanide molecule that's bound to the B12 uses up methylation cycles to detox it from the body (avoid). Folic acid is a synthetic form of Folate and it's believed to create a paradoxical reduction in Folate levels (avoid). Folate is found in leafy greens. Methyl-Folate is an active form and Folate/B12 have a synergistic relationship. I believe Folinic acid, which can be taken in supplement form is also beneficial to the body for repair processes. Some methyl-folate becomes folinic acid as it goes through the rounds. Some may become Methionine and eventually SAMe. I personally struggle a bit with folate and B12. I do better getting them from food than a supplement. But even eating beef liver can kick up my anxiety and anger symptoms. I have to ramp up very slow and take breaks. I believe this has something to do with a mutated CBS gene and/or SUOX gene. I believe I've had some luck when reducing high sulfur foods during times I want to ingest more methyl groups. Way beyond Dr Sinclair's talk about the importance of Folate. I believe he wants to stress the importance of all B vitamins on methylation. Folate being important in reducing homocysteine levels which when high, increase a risk of heart attack or stroke. Reply @greenLaVitameadows @greenLaVitameadows 1 year ago Thank you always ! Reassuring to know with great experts 2 Reply @LindyPureResearch @LindyPureResearch 1 year ago David, your podcast fans love Matt; just MUST keep him. The good natured ribbing between you two helps keep the science from getting boring. Reply @CryptoQuest @CryptoQuest 1 year ago valuable information as always thank you for making this. 2 Reply @isabelleebel8552 @isabelleebel8552 1 year ago Thank you so much for this great podcast! would like to know if it is ok to take Metformin and Resveratrol with the same meal all at once or would this reduce/inhibit the positive effects? 6 Reply 1 reply @MrJamesdryable @MrJamesdryable 1 year ago Nice of Matt to have David on the show again. 4 Reply 1 reply @rickg.1545 @rickg.1545 1 year ago This was all great information, but when it comes to brain health and especially preventing dementia, the studies on fasting, ketogenic diets, and sauna are really important! 5 Reply 3 replies @ligiasommers @ligiasommers 1 year ago (edited) Best podcast !!! And I study many of them !!!! 🙏🏻✨🌹🌟🌟🌟🌟🌟 I am using AGreens and will check the others 1 Reply @michelem226 @michelem226 1 year ago With sleep, not enough people are talking about sleep apnea and how damaging to the brain it is. So many people have it and don't know. I have it, and I don't fit the profile, because I'm skinny and female, so it took a while for me to get a proper diagnosis with a lab sleep study. Snoring, frequent waking, nightmares, heart racing, breathing difficulties can be signs during sleep. And sleepiness and brain fog during the day is also a sign. I have a fitness watch that tracks sleep stages and pulse oxygen. Sleep apnea makes my oxygen drop when I'm sleeping, keeps me out of deep sleep stages, and causes my heart rate and stress levels to go up during sleep. I now have a dental device that keeps my jaw forward and airway clear. 1 Reply 1 reply @coachbrendan @coachbrendan 1 year ago I always enjoy listening to Dr Sinclair discussing Longevity strategies, and applaud him for his work. Without criticizing him, I just want to draw attention to the discussion on B vitamins. At time stamp point 20:26, Dr Sinclair mentions that Folic Acid IS Vit B12 (cobalamin), which it is not. Perhaps his colleague should do a final fact check with him before the interviews, as in this case particularly, a pure vegan may be mislead into believing that they get sufficient B12 by virtue of them obtaining folic acid from their diet, YET, B12 is not bioavailable from any plant based sources, the few that may have it, nor even gut bacteria. B12 has to be supplemented, or derived from animal sources. 3 Reply 1 reply @Thebusysuperhuman @Thebusysuperhuman 1 year ago Thank you very enjoyable and useful as always Reply @cindybelle1752 @cindybelle1752 1 year ago (edited) Lung diseases including COPD are supposedly irreversible, are in the top 4 of the deadliest diseases, but never seem to be included in any new health discoveries. Could lung diseases perhaps benefit or even be reversed using David's discoveries? I'm very much enjoying the podcasts but was hoping to hear lungs included. Reply 1 reply @devonk298 @devonk298 1 year ago Matt is an awesome cohost he is a keeper! Reply @explorersoftheworld1193 @explorersoftheworld1193 1 year ago thank you for very valuable and useful knowledge, I would be interested in the topic of fertility in women, how to care for it and whether it can be kept Reply @vincentack1323 @vincentack1323 1 year ago I would love to hear david more explaining more without the hosts interruptions Reply @evolve101 @evolve101 1 year ago (edited) Two more episodes! ;) Thanks! I will listen later on. Awesome. I'm kinda slow.. but find this stuff eventually. Could have been next year also, so yeah.. could have been worse maybe. ;) Keep it up! I love this podcast!! I could use some brain health tip also. Now i'm a put some shrimps on the ba... nah i'm gonna rest some. ;) No offense and that was not about your or others intelligence, i'm just racist.. No i'm not it was a joke i'm just tired. Peace out and thanks for sharing. You guys are smart for real! Australians seems to rock. 🙏 Reply @fne1198 @fne1198 1 year ago Could you guys please always make the distinction between the average population and an extreme athlete? There are some people who workout twice a day at high intensity, max-out their HR on a regular basis, are already at nearly keto levels of glucose, already take extreme cold plunges daily, etc. Should these people still consider things like Berberine, Resveratrol, NMN, etc? Or could these bring them to the other extreme of the spectrum? (similar to how an athlete could easily be sodium deficient while 99% of the population has too much of it. What is true for 99% of people is often the opposite for extreme athletes). Thanks! 1 Reply @nicolasguarin3302 @nicolasguarin3302 1 year ago This probably the only podcast that will give you ROT (return on time). Great knowledge. Reply @slayeralchemist @slayeralchemist 1 year ago Interesting. I always heard there wasn't such a thing as having too high b12 levels 3 Reply 1 reply @UPSCBAABA @UPSCBAABA 1 year ago (edited) It would be Good If you Guys could Give 1-2 Daily Simple Practice at the end of each episode related to that topic which everyone can follow since not everyone can afford various drugs,tests n medicine etc. 4 Reply @jawadkarim6615 @jawadkarim6615 1 year ago A Big Salute for David Sinclair. 3 Reply @iggybiggy821 @iggybiggy821 1 year ago So interested in knowing the updated Info on NMN and cancer. I’m a cancer survivor so this is of particular importance to me. So when I found this out I came off the NMN. But I had such great benefit from it soooo I miss it! What’s the bottom line? Reply @cappypyramsaudpate5535 @cappypyramsaudpate5535 1 year ago I wonder if David could touch up on some mental health or behavioral topics if that would be of any relevancy. Not to be a an absolute downer but i come from a history of existential nihilism and so far, finding an ultimate purpose in life is what drives you out of this depression. Well as we extend ourselves, how can we stay happy or neutral for years, or even just sane? 1 Reply @universe6319 @universe6319 1 year ago (edited) Hello Dr. Sinclair Thank you for sharing a cutting edge information with all of us. This is indeed a life changing data. Would you please give us your take on : Royall jelly, Bee Bread, Bee Polen and Honey in regards of longevity, reducing inflamation and the risk of aging related diseases ? It is well know that the Bee queen eat only Royall Jelly and the life span is 5 to 6 years while the normal ,workers live 30- 40 days maximum. It is also a common fact that many of the bee keepers, live long and healthy life due to their exposure to bee products+having the benefit their office to be the nature.:-) So if you can share with us what you know about the bee products and if they could help us in terms of longevity, preventint aging diseses, and reducing inflamation. Thank you. 13 Reply 4 replies @lynnnestor7985 @lynnnestor7985 1 year ago Brilliant content …yet again! Reply @gustavopanesso7297 @gustavopanesso7297 10 months ago Great video. Thanks a lot! .. can you present a podcast on vestibular problems.. I have that. Thanks. Reply @carlor.s.4742 @carlor.s.4742 1 year ago I'm always amused when experts say "talk to your doctor about it." The vast majority of Drs know very little about nutrition to start with. I asked my Dr if he could get a HOMA-IR test for me & he had zero clue as to what I was talking about. With info readily available on the net now, some patients are light years ahead of their Drs! 3 Reply @Frazer247 @Frazer247 1 year ago I have read the book Life Span twice. I have watched most of David Sinclair's Youtube clips and interviews. I have given several copies of the book as gifts to friends. I have been following David's recommendations to improve my overall health for the past two years. However, witnessing how "religiously" David defends the use of Resveratrol despite all the new research studies that say the opposite, has made me question the "objectivity" and "authenticity" of David Sinclair as a scientist. I have no doubt David Sinclair is a great businessman. "Objectivity" is a true characteristic of a "real" Scientist. 43 Reply 10 replies @MyLittleMagneton @MyLittleMagneton 1 year ago In the next episode, could you talk about what kinds of sensors you'd want to see rolled out into next gen smart watches? I say smart watches specifically, because I believe that's the gateway to mainstream adoption. Reply @veronicaroman1086 @veronicaroman1086 1 year ago Thank you David Sinclair!! Im curious on what kind of exercise & frequency impacts the brain and is most optimal for longetiviy (but also a functioning productive mind) I understand there is a difference in health vs performance but am excited for your research 😊 8 Reply 5 replies @marianblum1064 @marianblum1064 1 year ago David suggested taking "at least 1 gram EPA". My understanding is that DHA is pretty readily converted to EPA but not viceversa so I've assumed it was probably ok to get more DHA. Algae supplements are all higher in DHA so to get a gram EPA you'd have to get even more DHA (very pricey, too). A few minutes later David advises to take at least a gram of 'these fatty acids' daily. Is that in total or each? I realize this is not medical advice but I think the message could be clearer. Reply @HanaHana-sg2ng @HanaHana-sg2ng 1 year ago I had hemoptysis 2019 it went away, last week I was having same symptoms so my Dr wanted me to get CT Scan to see what is going on in my lungs. So after I got the CT Scan I got neck pain and inside my left ear feels wierd. 20 hours passed since I had the CT Scan and I still have neck pain. I am very worried about radiations. I would love if you tell me what kinda of health food or vitamins I can take to get rid of the radiations. Thank you. 1 Reply @iluminative @iluminative 1 year ago Genius levels of knowledge! 2 Reply @sherlock1holmes64 @sherlock1holmes64 1 year ago The Cappuccio study showed a 30% increased risk of dying in people who OVERslept (ie more than 9 hours), for the undersleepers (ie <6hrs) it was 12%. Reply 1 reply @chickensandw1tch @chickensandw1tch 1 year ago (edited) 0:50 ❤️💯😎 1:30 trippy! 3:00😍🙏🏻😎 9:00 😎🧠 14:10 lol savage times💀😂 18:00 3 longevity pathways 25:00 resveratrol🙌🏻 34:10 oleic acid and omega-3 42:00 metformin 54:00 sleep🙏🏻 Reply @renencar2684 @renencar2684 1 year ago What i like in this interview is it is so organize and you can track back what you have missed.kuddos new follower Reply @imdiyu @imdiyu 8 months ago We have a saying in Hindi "Dil toh bachcha hai ji"... Meaning heart is a child... Turns out Brain is the childish of them all 😁 Reply @kerlytrujillo1934 @kerlytrujillo1934 2 months ago Me gusta mucho su trabajo Reply @natalieaxl804 @natalieaxl804 1 year ago Thank you, Dr, David 🙏 2 Reply @sharynthevegan8029 @sharynthevegan8029 1 year ago I put dried seaweed in my spice grinder and make it into a powder, then I transfer it to an empty spice shaker and literally put it on everything. Like salad, my avocado toast (which is not toast, it's a flattened air fried potato 😁) topped with homegrown sprouts 😋 I'm new to your channel, but I would love to see you interview Dr Dean Ornish on the topic of Alzheimer's. He's doing a study now that I think you and your listeners would be interested in. 3 Reply 1 reply @altiarissuralis8535 @altiarissuralis8535 1 year ago Thank you Dr. Sinclair, been following you for a while. 👍 Recently, there’s been some debate and pushback from Dr. Charles Brenner, and as a layperson I can’t seem to understand all the technical details. Can you eventually shed some light on this disagreement? Thanks. 7 Reply @twainmom4999 @twainmom4999 1 year ago (edited) Matt is a good writer & communicator but, man…just looking at him…he doesn’t look like he walks the walk. Sinclair, on the other hand, is fit, you can tell he’s himself is implementing everything (intermittent fasting, nutrition, supplements, physical exercise) he advises people to do. The physical contrast between the two is glaring. Reply @bradstonestreet9940 @bradstonestreet9940 1 year ago Sorry to hear about your mind going Dave. I'm 51 and my mind is still as strong as it has ever been. I don't know what to tell you. Reply @shylaandrews4435 @shylaandrews4435 1 year ago Hi Dr. Sinclair been following all your videos incredible information thanks for the same can you throw light on sleep apnea how to tackle this health problem.. Reply @eddiehanson2738 @eddiehanson2738 1 year ago Thank you. This is life-changing viewing. Reply @Mashynia @Mashynia 1 year ago great episode! thanks 💛 Reply @paulwolf3302 @paulwolf3302 1 year ago 🧠reversing brain aging and getting your lost memories back again. The Doctor is always way out there ahead of the science fiction writers. Have any of his products ever worked? 1 Reply 8 replies @akpinera @akpinera 8 months ago (edited) Fascinating podcast, gents. Just a note, Folate/folic acid is actually B9 and that’s what’s prescribed to pregnant woman. B12 is cobalamin.💊 Reply @tobi4647 @tobi4647 1 year ago Realy enjoied the episode. Can polyphasic sleep infuence aging? Or what are your thoughts on polyphasic sleep in tirm of aging? 1 Reply @youremom5463 @youremom5463 1 year ago So how do we offset the detriments of a missed nights sleep? How do we recover most efficiently Reply @Mysteroo @Mysteroo 1 year ago I've read that folic acid is something you actually want to avoid- whereas folate is what we need more of 1 Reply @MosesRabuka @MosesRabuka 1 year ago “The brain ages slower than the rest of the body, significantly slower. Your brain is biologically younger than you are” 1 Reply @biomedtube3479 @biomedtube3479 2 weeks ago Dear Devid Sinclair Our team has succeeded in confirming the safety of specific embryonic growth factors by injecting through intra-venous injection, we got expected results, immune , biochemical and hematological parameters are with in normal limits. after this we have started ultrasound guided intra-renal to CKD Rat model and we got all renal parameters with In normal limits and we are waiting for proteomics analysis and histopathology study reports after recovery Reply @StarshipTroooper @StarshipTroooper 1 year ago Growing body of evidence around the neuroprotective effects of ketogenic states and ketosis! Great option for mild cognitive impairment, early Alzheimer’s. Definitely missed that topic here. Reply @TM-cb2te @TM-cb2te 1 year ago I'm very fascinated to know what Dr. Sinclair is talking about, when he refers to chemical molecules, and genetic structure. For someone with a STEM background, but with only high school level biology knowledge, what are the fewest number of classes one would need to self learn the knowledge to know what Dr. Sinclair is talking about? Reply 1 reply @loriej2687 @loriej2687 1 year ago Love this topic! 1 Reply @tradet8767 @tradet8767 1 year ago Great as always except the voice delay, noticed something simular in earlier videos too. Minor inconvenience, thank you for sharing :) Reply 2 replies @sk.n.9302 @sk.n.9302 1 year ago (edited) No, no, a mediterranean diet is not a hardship experience for the body (on the contrary, it’s significantly better than standard american diet), but intermittent fasting is a hardship, in a good way. Sinclair was mixing these two up. Reply @CookieCat2019 @CookieCat2019 1 year ago Hi Prof Sinclair, while I thank you for your great research and scientific work, I would like to draw your attention to one important aspect of your approach. By informing people about potential benefits of NMN and other molecules you are taking and not revealing the reliable brands, you are exposing people to numerous low grade or even dangerous products out there. This could potentially harm or seriously damage the health of innocent people who just want to be healthier. Why not reveal a couple or safe and reliable brands? Reply @callofthedark @callofthedark 1 year ago (edited) Let’s Go..As much as I am excited to hear each episode, it makes me countdown to the last couple of episodes left.😣 3 Reply @learnmore6120 @learnmore6120 1 year ago I am applying for Harvard postgraduate next year hopefully I will be able to meet David. 1 Reply @nemaznachenie9997 @nemaznachenie9997 1 year ago I recently read viagra reduces Alzheimer’s by 70% and it could be to do with increased blood flow. If you ever do brain health update video it would be nice to touch on viagra. Thank you 2 Reply 1 reply @cryptokids3760 @cryptokids3760 1 year ago Thanks for your work and for sharing with us! You da man 2 Reply @bigpicturegains @bigpicturegains 1 year ago Practical takeaways you can implement immediately: Get good quality adequate sleep, exercise, eat well and ensure you are getting enough essential fats. 9 Reply 1 reply @isabellawolfskeil2715 @isabellawolfskeil2715 1 year ago Can you create a downloadable pdf which summarizes the protocol you suggest or at least re-cap what actions we can take at the end of each episode? Reply @tlhpeach5450 @tlhpeach5450 1 year ago Great episode! My question is what about melatonin…good or bad for sleep? 4 Reply 1 reply @msaz3027 @msaz3027 1 year ago I really like to hear about infertility and premature menopause. 1 Reply @GregEwing @GregEwing 1 year ago So i am in NZ. Getting these supplements are bloody expensive, if i can even find them. Also metformin is prescription only, its hard to get doctors on your side here. (struggling to get them to just give me results from my last blood test! ). So kinda stuck with the "no supplement" way. But anyone else here have hints for NZ, i love to hear em. Reply @neilquinn @neilquinn 1 year ago David, how much do we know about how much the MTHFR mutations affect all of the methylation pathways and how bad they are? For example this SNP: rs1801133(T;T) - homozygous for C677T of MTHFR = 10-20% efficiency in processing folic acid = high homocysteine, low B12 and folate levels. Only 10-20% efficiency seems scary, and nearly 9% of caucasions have this variant. (higher in others). Are there other better biomarkers you would measure around b12/folate? Reply @melissatodd2011 @melissatodd2011 1 year ago How important is eating before you take supplements. I notice when I take a lot at once I get very nauseous. Love you guys! Reply @yayangtapir4130 @yayangtapir4130 1 year ago Mathew is looking younger day by day....I think he is listening to david to start all the supplements. His collection of hats is awesome...😁😃 11 Reply @youtubeiscruel3946 @youtubeiscruel3946 1 year ago Wow hes been taking athletic greens for years! Amazing he has forgotten to mention it in his publicized supplement stack until he was being paid to say he takes it. What a coincidence! 6 Reply 2 replies @skyrider4789 @skyrider4789 1 year ago 😁😆So funny with the opening -- "So far" 0:46 Thanks guys. Keep up the great work! 1 Reply @hassansyed5661 @hassansyed5661 1 year ago Water intake also increase the blood flow and very effective for brain health Reply @ArhamAbbasi @ArhamAbbasi 1 year ago Would love to have your input about corticobasal degeneration. My aunt is suffering badly. 1 Reply @sunmoon-84 @sunmoon-84 1 year ago (edited) I am curious; would there be any rebound effect if the supplementation were stopped? Reply @ye.katerina @ye.katerina 1 year ago Great talk! Reply @ethancowart6765 @ethancowart6765 1 year ago i wanna hear david sinclair talk about the molecule 5 amino 1mq. that would be cool Reply @tomc1121 @tomc1121 1 year ago David, has your lab done this... After you reset the epigenetic clock has anyone checked the telomere length before and after. The reason I am asking is if telomeres are not lengenthing then the cell could unravel in later life. Defeating the reset. Reply @whatUneverknew @whatUneverknew 1 year ago Rofl. That executive function joke slayed me! 🤣🤣🤣 Reply @sharynthevegan8029 @sharynthevegan8029 1 year ago I don't think we're living longer, I think we're just dying slower... 2 Reply @kmichalene @kmichalene 1 year ago Again, my question is do these interventions, which increase NAD, also increase production of already damaged, cancer-promoting mitochondria? You addressed this question in another video, but I wonder if you might go into more depth in the future. Reply @stjameso15 @stjameso15 7 months ago Excellent episode .. how's about providing links to the supplements you mentioned, that is the brands you use or "Trust". Thx Reply @user-es4fx7wo6r @user-es4fx7wo6r 1 year ago (edited) I know that most B- vitamins come from meat. So where to get them from when i gonna switch to a Mediterranean diet? Do we take them in supplements as well? Or do we still eat some meat occasionally? Also, i would love to hear how vitamin daily dose norms gonna change when we gonna switch to this stress activation life. As i understood we definitely gonna need more of b3 and phosphorus and mb something else? would be great to hear new proportions for ppls who yet cant track their blood levels directly every day with these devices. 1 Reply @pontusolsson7002 @pontusolsson7002 1 year ago I will say this: David Sinclair is fairly sure about the things he speaks about, however he is not 100% certain, I did see some doubt in him. Essentially, what he has said so far might change to a big or small extent once time passes, and more research is needed. But the knowledge is still valuable, but may feature some unknown flaws and unintended sideffects. We should keep an open mind, but be aware of this as well. 10 Reply 2 replies @shyrinekessentini167 @shyrinekessentini167 1 year ago Can you please do a podcast about repairing the cells in the body caused by cancer treatments, stress, radiation…thx 9 Reply 2 replies @willisthewise5240 @willisthewise5240 1 year ago What are your thoughts on hyperbaric oxygen chambers in lengthening telemeres? I've read it causes oxidative stress on the body similar to fasting. 1 Reply @snelson7679 @snelson7679 1 year ago A futuristic movie made in 2005 called 'The Island' with Ewan McGregor & Scarlett Johanssen had a scene where Ewan (with the single prick of his finger each morning) had his blood analyzed and was told what to eat that day. Island Tracker seems something like that, but not as simple. :) Reply @makemoneymedia5771 @makemoneymedia5771 1 year ago Thank you so much I love you guys!!!! 1 Reply @MrEtc31265 @MrEtc31265 1 year ago I have started using a Far Infra Red sauna blanket that I believe is improving my blood circulation. Any thought on Astaxanthin as a supplement? Thanks. 3 Reply @chonrodriguez7572 @chonrodriguez7572 1 year ago I recently stopped drinking coffee just to see how my mind and body would react first my head hurt so bad the next day the day after aswell. I feel stronger during my workouts as I was always taking coffee for the last 6 months to hit the gym and now I don't even feel like I need it . it was all in my mind thinking that coffee would be the only way to get gains. nothing but water and ashwagonda and some good meals low carb high protein. I feel really good in class I can concentrate a whole.lot more !!! Reply @robking3489 @robking3489 1 year ago Dr Sinclair, please address the controversy regarding GSK dropping the company you sold to them and the discrepancy of resveratrol findings. Thank you! 2 Reply @ramentabetai1266 @ramentabetai1266 1 year ago Montelukast decreases brain inflammation btw. Worth checking it out. Though rarely it can cause depression. Reply @josephdalecy7285 @josephdalecy7285 1 year ago I think it would add a lot of value to include pictures of what you're both talking about. Reply @inhocsignovinces8061 @inhocsignovinces8061 1 year ago I wonder if Dr Sinclair has any thoughts on Piracetam, the original nootropic. Studies have found it to protect mitochondria against different conditions associated with oxidative stress, including aging. 2 Reply 1 reply @lucianobarrantes @lucianobarrantes 1 year ago Christian Slater could play Dr. Sinclair in the movie about longevity 1 Reply @daisyhuang9930 @daisyhuang9930 1 year ago Thank you for your sharing 😊 Reply @WhereNerdyisCool @WhereNerdyisCool 1 year ago I'd be really curious his thoughts on resveratrol pterostilbene 2 Reply @gemagemproimage675 @gemagemproimage675 1 year ago Doctor, I have a question could you explain if possible what happened in the case of Shauna Rae or similar cases, Is it possible to see something similar in someone who is 20 years old? hope you see this question . Thank you for your work. Reply @kdcounseling @kdcounseling 1 year ago Perfect timing thank you 😊 2 Reply @hombrex7668 @hombrex7668 1 year ago Thank you both👏👏👏 Reply @snowwhite8143 @snowwhite8143 1 year ago (edited) 52:37 I think he meant the Hypothalamus! Thank you so much for this. Reply @primtaketv2338 @primtaketv2338 1 year ago Health and social care for these conditions require multisectoral and interdisciplinary collaborations with a holistic person-centered approach focused on promotion, prevention, treatment, care and rehabilitation over the lifespan and the active engagement of persons with lived experience, their families and carers. Reply @flyingsneetch @flyingsneetch 1 year ago Hi! Is it possible to know what the future episodes will be about? Will you please do one on menopause? Thank you :) Reply 1 reply @RoseMary-gl4ee @RoseMary-gl4ee 1 year ago Once I had omega3 for too long, when undergoing a surgery I almost bled to death. Reply @BB-rw5yf @BB-rw5yf 1 year ago Getting metformin is almost impossible in the uk and maybe also in other countries its very hard, or impossible - unless you have diabetics or are a famous person who seem to be able to bypass the doctor training system. Is there an alternative ? Reply 1 reply @mowthpeece1 @mowthpeece1 1 year ago So come to find that Niagen causes some really bad headaches. I wish he had told us that. 1 Reply @bartangel4867 @bartangel4867 1 year ago I read that anthocyanins help with neurogenesis is that true? and although some foods like blueberries bilberries and purple corn have lots of them they are low in bioavailability. what foods should I eat that would help with bioavailability of anthocyanins? 2 Reply @grahamfleming8139 @grahamfleming8139 9 months ago Been on nmn for two years ,next year I will be sixty still work six days a week .Also take olive oil ,metformin, plenty vegetables and fruit. As well as apeginin before sleep, in the form of parsley, but sprinkle my food with oregano or basil. One side effect, other than a lot more energy is it's like some one has power washed my eyesight I now see trees in 3d ,I have never had that before,is that normal? Reply @marthievalentine4766 @marthievalentine4766 1 year ago Halo Dr Sinclair, Thanx for your podcasts. I am learning a lot. I do want to ask. Have you done some research on Chemo brain? The supplements you talk about are not recomended if you have cancer. 2 Reply 2 replies @yanshen1795 @yanshen1795 1 year ago You mentioned elsewhere that you were working on restoring eyesight in mice and then maybe do human trials ... would that method work on Parkinsons to make more dopamine producing cells in the brain? if so I am very interested about that ... Reply @christinley5213 @christinley5213 1 year ago Ok… im still waiting for the next season to start.. will there be another? I check ev monday… please… make…. More… videos lol!!!!! Reply @SachinSingh-ni4vt @SachinSingh-ni4vt 1 year ago Hi Professor, How the excessive consumption of the high sugar content food effect brain function and how sirtuins play the role in pschatric disorders induced due to the high sugar consumption. 2. What kind of the epigenetic change induced in the brain due to prolong high sugar consumption Reply @YY6951 @YY6951 1 year ago You forgot Lythium orotate. It hugely increases BDNF 1 Reply @theresatilbury1070 @theresatilbury1070 1 year ago Hi, with regards to bloods I have heard you speak about 7 main biomarkers to check (on the Andrew Huberman podcast), but please would you kindly list what these biomarkers are. Many thanks. Reply @claudiaclaudia6884 @claudiaclaudia6884 1 year ago (edited) What happens if someone taking Metformin without having diabetes stops taking it? Do things function as before or they need it to take it for the rest of their life to be ok? Thanks. Reply @ltd449 @ltd449 11 months ago ive tried the dr's method of fasting ie skipping ,breakfast and lunch,but have found im not eating enough fibre .Also i tend to over eat dinner .So experimenting with whole day fasting ,ie two days of healthy eating ,incl cutting sugar intake .Then the starvation diet day .Ill see how i go? Reply @ScottSummerill @ScottSummerill 1 year ago Seriously suggest that Matthew read the ingredients on his seaweed. Think you'll find added blue and/or green dye. It's why I stopped eating seaweed. So again, you mentioned red wine but a) it does not contain a significant amount of resveratrol, b) any amount of alcohol hurts the brain and liver, and c) I thought you stopped drinking. Did you or not? Thanks! Reply 1 reply @kantrajk277 @kantrajk277 1 year ago Thank you so much ❤️🙏 2 Reply @erika8884 @erika8884 1 year ago David, there is a dire need for raising the IQ in millions of people. 😁 Reply @mhelsher1 @mhelsher1 1 year ago (edited) Question/invitation for conversation: I've had great success with improving my health on a carnivore diet and intermittent fasting. The talk about a plant-based diet here makes me nervous. I've been a vegetarian for a few years and even went vegan for a while, but I've never felt this good and seen so many improvements as I have on the current protocol. I'm 60. I no longer have all the bad (very bad) habits I acquired in the 60s and 70s. I work out a the gym a few times a week. I'm taking NMN and resveratrol, a natural sourced D3 (5000 IU) on occasion along with magnesium and potassium, krill oil, AKG, and am looking into metformin. So, my question is, am I sabotaging the potential longevity I'm hoping for on this diet? Thanks in advance! 7 Reply 15 replies @1dekar07 @1dekar07 1 year ago Is metphormin safe for gut health? Reply @jeffwillems73 @jeffwillems73 1 year ago What about creatine as a supplement? Good to fight ageing when combined with exercise or bad as a signal that resources are plentiful? 1 Reply @filipinoblackpill6194 @filipinoblackpill6194 4 months ago Hope you see this sinclair, our brain got heavy metals and other internal organs which we get from food water and air. detox heavy metals to prevent dementia. cilantro every meal for 5 months. or calcium disodium edta. Reply @relaxo2739 @relaxo2739 1 year ago I cannot profit from the Level offer as I live in Australia 😞, thanks for the content Reply @FenixFlight @FenixFlight 1 year ago If the CD ROM is the genome and the CD reader the epigenome, then, in that analogy, aging should be caused by the reader's laser losing gain instead of CD scratches, right? Reply @anmayo917 @anmayo917 2 weeks ago Please talk more about b vitamins :) Reply @28lester @28lester 1 year ago (edited) Resveratrol from red wine - you mentioned in a previous podcast that one glass of red wine per day has such small amounts of this that it makes it inconsequential, and that you would need to drink thousands of glasses of red wine to have any real meaningful result perhaps over the course of years. Is the benefit higher than the liver damage, or potential psychological addiction to alcohol? Wouldn't taking a supplement or perhaps finding a less damaging source of resveratrol be more beneficial? 1 Reply @marz.6102 @marz.6102 1 year ago Could you talk time perception in the human body and how to slow it down Reply @scottk1525 @scottk1525 1 year ago Off topic, but I sure wish David would take the time to respond to Brad Stanfield's concerns about Resveratrol, namely that its efficacy as a longevity molecule has yet to be reproduced outside of Sinclair's lab (even by the ITP,) as well as concerns over possible dangers of long term use. Brad has been respectfully and patiently making videos and sending tweets to David about this for years, and so far, all David can muster is a couple dismissive & passive aggressive tweets. I'm glad it's decisive in David's mind, but us normies would appreciate some clarification, as it seems that Brad has a case here, and that David is being intentionally evasive. 19 Reply 8 replies @FOR8YESHUA @FOR8YESHUA 1 year ago A Vegan Mediterranean+ diet is to consume grapes or fresh Grape Juice that include the skin of grapes (avoid wine to avoid the alcohol to avoid increasing the homocysteine levels), and olive as a whole food instead of the oil (missing nutritional benefits of whole olives). Reply @poonamprabhat0505 @poonamprabhat0505 1 year ago I have a 16 year old daughter with low functioning Autism and I’m hoping and praying some day you will come out with something which can help me with her and make life better for her. Kindly help me by answering if I can introduce some omega 3-6-9 in her diet along with other things. I wil really appreciate if you could help me @drdavidsinclair 🙏 Reply @TheBody360 @TheBody360 1 year ago If you go to your GP in the UK and ask to check homocysteine they just look at you aghast. Such an important marker to check and monitor closely.....I hope the budget for preventative healthcare changes in the UK....and very soon! Reply @sharonw4581 @sharonw4581 1 year ago 5-HTP at night with Magnesium and Niacin really helps mood and sleep. I am 65 and was not sleeping well at all before. Reply 1 reply @KirstiCheetahh @KirstiCheetahh 7 months ago The French mediterranien food is not at all mostly plant based. We eat lots of fish, beef, sheep, cheese, butter, cream, saucisse, snails. Meat and dairy are very healthy when it is made from grass fed animals! Greetings from France! Reply @ann2277 @ann2277 1 year ago When you sleep for around 7 hours , but you sleep late like 2 or 3 am but wake up late like 9am , is this alright? Reply @cassianyhvh7220 @cassianyhvh7220 1 year ago In these podcasts are there any references to metformin as a longevity drug? Reply @saulsheehy9405 @saulsheehy9405 1 year ago Will there be another updated book anytime? Reply @motivationseeker60 @motivationseeker60 1 year ago These guys are the best Reply @jackjack-xw1ci @jackjack-xw1ci 1 year ago The duo is so funny together. Dr.Sinclair has such dry wit =)) haha. Reply @veejayroth @veejayroth 4 months ago With all due respect, David, at around 27:00 you mixed up Folic Acid (B9) and B12. Quite a difference there., though both are very important. Reply @chrisbenn @chrisbenn 8 months ago Super nice video! :-) But the sleep part… if that is true, having kids is not a good thing? Seems like a bad Evaluation to have NOT developed some kinda healing for a lack of sleep after many years of having young kids? Reply @JeffNixonComedy @JeffNixonComedy 1 year ago I know my brain is young because it still thinks farts are hilarious. 50 Reply 6 replies @lpodverde @lpodverde 9 months ago What about people who have a genetic predisposition for neurodegenerative disease, especially rare ones, are their lifespans set in stone? Do these longevity protocols do anything for them? Reply @JohnDeanMusic @JohnDeanMusic 1 year ago Love Matts hats and overall sense of fashion. 1 Reply @yannlang4849 @yannlang4849 1 year ago I love Professor Sinclair and I admire him, but instead of speaking for nothing he better get us his rejuvenating solution. Reply @PieterDaniell @PieterDaniell 1 year ago Like listening to an add or billboard. Keep it real Reply @sk.n.9302 @sk.n.9302 1 year ago Best recommendations for brain health are Drs. Sherzai (both neurologists). Am shocked that too much of what Sinclair says is either incomplete or false. 1 Reply 1 reply @marymc4044 @marymc4044 1 year ago Not so. It’s not so bad to lose your mind as long you are happy, or at least with a semblance of happiness, but most people I’ve seen with dementia are querulous, complaining, not happy. Perhaps a cheer-up drug? I read recently that laughing gas has used effectively (don’t laugh). Reply @johny16G @johny16G 1 year ago Blessed day with new upload. Thank you! Reply @ilyabykov2437 @ilyabykov2437 1 year ago (edited) "Yeah I'm 52" - Looks better than me at 30...he's not even gray? I've never seen anyone to look this young at his age... 2 Reply @creightonfreeman8059 @creightonfreeman8059 1 year ago Omega-3 fatty acids are plant oils. Algae (sea weed) is the best source of them. The only reason fish have Omega-3s in them is because they eat algae or smaller fish that eat algae. You can skip the fish and go direct to the source. There are a few companies that sell algae derived omega-3. The Only draw back to them at the moment is that because the volume sales is less than fish oils, the price is currently higher. You are less likely to get bio-accumulated pollutants from the algae derived oils than from the fish though. Pollutants increase in concentration the higher up you go on the trophic level. 6 Reply 3 replies @user-bg1zp8dk3l @user-bg1zp8dk3l 1 year ago What Sinclair says about people on plant-based diets requiring ALA instead of EPA/DHA is totally false. The conversion rate is terrible. Algae derived EPA/DHA supplements are readily available, especially online (I think I’ve seen it in Flintstone vitamins), and a perfect alternative to fish oil. Algae is where the fish get it from 2 Reply @5683saraswati @5683saraswati 7 months ago Do NADs help with aphasia? Can plaque be removed from the brain? Reply @jshtaway1 @jshtaway1 1 year ago “Red wine has very little resveretrol and it’s not worth drinking it if that’s what you’re trying to get” -DS …. “One good thing from the Mediterranean diet is red wine, because it has resveretrol” -DS 1 Reply 1 reply @Cindy24412 @Cindy24412 1 year ago Could you list all the supplements you take please? Reply @raimondsurtans6852 @raimondsurtans6852 1 year ago My homocysteine levels been high since I decided to test it. I got it once down to normal, only once. All I have found is that it is affected by B12 and folic acid. Can you help me to lower it? Reply @robertpearl1833 @robertpearl1833 9 months ago Are there any treatments for stroke recovery Reply @squirt3179 @squirt3179 1 year ago Is the dosing of NMN related at all to bodyweight? For example if you were 105 pounds do you still need 1 g? Reply @MrFoxRobert @MrFoxRobert 1 year ago Thank you! Reply @snowwhite8143 @snowwhite8143 1 year ago I just bought a bunch of Resveratrol. But I don’t really know what to think after watching Dr. Brad Stanfield’s videos. I wish you would address them. 1 Reply @orkurlander9504 @orkurlander9504 1 year ago Hi David, Any recommendations for inside tracker but in the UK? 1 Reply @javiersantos4385 @javiersantos4385 9 months ago Dr Sinclair should apply his own methods; he looks way older than in the videos from just a few years ago Reply @biplobpaul9073 @biplobpaul9073 1 year ago One thing is to say, olive oil is a must. 4 Reply @swenic @swenic 1 year ago Any advice for someone like me who has 'executive' distractions? I think I need the tldr straight and concise. Plis. Reply @bradstonestreet9940 @bradstonestreet9940 1 year ago I eat a ketogenic style and my cognitive function is incredible. I am 51, muscular and active. Explain that if you believe supplementation is necessary. Reply @RunToTheHills999 @RunToTheHills999 1 year ago Right. There is no point in reaching 100yo if you can't remember the faces of loved ones 1 Reply @susymay7831 @susymay7831 1 year ago Great timestamps! Reply @sophiasonen7994 @sophiasonen7994 1 year ago Please talk about Astaxanthin and what it is and does. Reply @tiararoxeanne1318 @tiararoxeanne1318 7 months ago (edited) Is it me or David Sinclair looks like a younger version of Christian Slater? Edit: he's 52??? WTF??!! Reply @mowthpeece1 @mowthpeece1 1 year ago I inherited at least 8 longevity genes (with the effective allele). I'm 58 and have ZERO medical issues, with one exception... High LDL. It won't drop from the 150s no matter what I do. And the one time it moved down a little my memory got frighteningly bad. It corrected with milk and eggs, but I digress... I can't help but feel it's protective, so I refuse statins. My grandfather on dad's side lived to 99, my mother to 97 (covid killed her, she was still strong prior), her sister to 100... I intend to break 110. My daughter has homozygous longevity genes (the G allele where it matters most, twice) With luck she could break 120. These genes really do work and it's very clear to me as I get older. No one believes I'm 58. I do not look it. Reply 1 reply @korniszon68 @korniszon68 1 year ago I don't sleep because I hear to David Sinclair podcast telling me I should sleep :] Reply @vladyslav743 @vladyslav743 1 year ago Every diet compared to standard American will show benefits. Mediterranean is the most studied, but not sure the best. 1 Reply @lpodverde @lpodverde 3 months ago (edited) I struggle with insomnia, like really bad insomnia, and can't keep my cyrcadian rhythm fixed on a schedule. Would NMN fix insomnia? Reply 3 replies @Cherryontop10 @Cherryontop10 7 months ago You speak of metformin as something to consume casually but it’s in fact a drug that’s not easy to get and usually used for type 2 diabetes. It also comes with tons of side effects and consumption of some foods are discouraged. Instead emphasise how to get it naturally or label warn when speaking of it. Reply @parsellart7805 @parsellart7805 1 year ago Do you know what causes "brain fog" It is a pain to deal with. I am 79, but I also have younger friends in their 40's that suffer from it. I have been all over internet and to no avail. It does not seem that they have nailed that down or maybe they don't think it is serious enough to address. What do you think and know about it? Thanks Reply @pureffm @pureffm 3 months ago What about Lion's Mane? It is widely touted as one of the best brain supplements? 1 Reply @blackmartini7684 @blackmartini7684 1 year ago Can you do a video refuting the claims that resveratrol doesn't work on sirtuins? There's been several new studies I would like to hear your take on those studies 10 Reply 3 replies @TilveranWrites @TilveranWrites 1 year ago How well does berberine stack up against metformin? I ask because berberine doesn't require a doctor's prescription. 1 Reply 1 reply @Rm7717 @Rm7717 1 year ago I think Sinclair confused dha and epa no? Dha is the o3 more important for brain health at least as espoused by most medical professionals Reply @anmayo917 @anmayo917 2 weeks ago (edited) 52:35 hypothalamus Edit: everyone mixes them up though 😂 Reply @andreasstuermer4946 @andreasstuermer4946 1 year ago (edited) Is there a commercial service that you can send cells to, so they measure the DNA methylation clock using the Horvath algorithm? 1 Reply @yessir7430 @yessir7430 1 year ago Which would you recommend: NMN or NR+Pterostilbene? Reply @someone-lm3ln @someone-lm3ln 1 year ago Thank you! Reply @subiradukes7058 @subiradukes7058 1 year ago So how much is sleep is optimal? I don't think I heard that in the sleep portion. Is it really 7-8 hours, or as I've heard 5-7 hours? Reply @thomasf.769 @thomasf.769 1 year ago I'm taking 1 gram of MNM per day. Is it better to take in two doses (500 mg each) or once a day better? Reply @narcisaavataji1032 @narcisaavataji1032 1 year ago Hello! Do you have any research on autism? Thank you in advance. Reply @jefflittle8913 @jefflittle8913 1 year ago I think you are making a big mistake with respect to folic acid. Our bodies use Folate, not folic acid. We used to think that folic acid and folate were interchangeable, but in another instance of "it turns out that we are not rats", folic acid is converted to useful folate far slower than we previously thought and large quantities of folic acid are bad for the liver. If you supplement, make sure you are getting folate and not folic acid. This is another argument for making sure you have plenty of greens. Reply @dbehr4869 @dbehr4869 1 year ago 27.22 Folic acid is not the same as Vit b12. Folic acid is vitamin B9. Reply @MinMin-kv3rv @MinMin-kv3rv 1 year ago (edited) David needs co host, without them, he sounds like a pastor on Sunday mass 😋 Reply @NEdumpling @NEdumpling 10 months ago does anyone know if cooking destroys omega 3 fatty acids? say if i get them from fish, or maybe walnut oil. thanks! Reply @dorotabrown7917 @dorotabrown7917 1 year ago ❤️❤️❤️👏👏👏superb info😘😘😘 Reply @victorlouie1068 @victorlouie1068 1 year ago Where can I find enamen supplements for sleep health. Great show! Reply 1 reply @douglas.abramski @douglas.abramski 1 year ago Superb! Reply @OptimalLiving2.0 @OptimalLiving2.0 1 year ago So does methylcobalamin increase methylation? Is that what's being said and what about the synthetic form of B-12-cyanocobalamin. Can that increase methylation as well? Reply @V.Hansen @V.Hansen 1 year ago What about meditation and breathing techniques? To lower your adrenaline and cortisol levels Reply @Mrgasman1978 @Mrgasman1978 1 year ago I am taking NMN and resveratrol 1mg each every other day and i have a question if anyone can help here. Could taking NMN on a daily bases, reduce the capability of our body to produce itself by exercize and fastings and ice bath? As i know, body is a lazy machine and if knows we take NMN orally, it won't want to make the effort producing it. So i am worried that, once i start taking nmn orally i will be hooked for life, since my body will lose the will to produce it naturally. 1 Reply @NaedMalario @NaedMalario 1 year ago So, a mostly vegan version of the keto diet is a brain win? 1 Reply @nsansa9234 @nsansa9234 1 year ago Could someone share a link to a photo that they described at 32:25? I didn’t quite understood how it should look like Reply @youremom5463 @youremom5463 1 year ago Arent PUFA toxic? Burning your pufa fat stores leads to alot of oxidative stress, harmful to your mitochondria. Something like that. Reply @summer7529 @summer7529 1 year ago So my question is "taking 1 gram of B3 (Niacin) will work equally??" Reply @Real_Food_Revolution @Real_Food_Revolution 1 year ago I heard that MCT oil is amazing for the brain!! Reply @Old-And-In-The-Way @Old-And-In-The-Way 1 year ago Important advice from a 75 year old. Avoid this kind of garbage especially. Get out the door and up the mountain, and in my case, play video games. I have been doing the latter for a long time, and now its how much cheese I can come up with for any given situation. Bows to Uncle Sheo. ;) Reply @jacky861025 @jacky861025 1 year ago Is there any way for people who stay up late for a long time to make up for the damage to the brain? (Already improving their work and rest) (Google translate) Reply @PedroRodriguez-zi9it @PedroRodriguez-zi9it 1 year ago I would like to hear David talking about the studies that say that resveratrol is not doing what David says in the body just works in co trolled environment in petri dish was kind of disappointing to hear that resveratrol is not good for what David says Reply @jackbuaer3828 @jackbuaer3828 1 year ago NAD boosters have not extended life in mice, at least in the most rigorous ITP trials. NMN made little or no improvement in human health in the first human efficacy trial according to Dr. Petter Attia. So are we being led down a rabbit hole? 2 Reply 2 replies @leonaowen9234 @leonaowen9234 1 year ago What can be done for bone health. just diagnosed with scoleosis and degenerative throsisic spine? Reply @gregrodgers3350 @gregrodgers3350 1 year ago I know specifying brands for NMN is sticky, especially if they aren't a sponsor, but wish I had some guidance from a pro. Amazon is plagued with fake or impure supplement products. Reply @MrEtc31265 @MrEtc31265 1 year ago In this series, have you spoke in detail about woman's health? 1 Reply @reviewfeedback495 @reviewfeedback495 1 year ago What about high does of vitamin c for exssive stress? Reply @ligdacastellanos1886 @ligdacastellanos1886 1 year ago Apart from NMN, magnesium, you mentioned something else I can’t remember something like altinium? Reply @markpelayo @markpelayo 1 year ago Thank you again <3 Reply @ianbaber7051 @ianbaber7051 1 year ago "My brain? That's my second favorite organ." Woody Allen. Reply @topdog5252 @topdog5252 1 year ago These r great! Reply @themitchellbrothers @themitchellbrothers 1 year ago Please please please, can you offer some clues as to which NMN producers are better? There are so many to choose from and rumours of many brands being dodgy Reply @jshtaway1 @jshtaway1 1 year ago Folic acid doesn’t have the methyl group and is not the same as folate, the natural form, which is methylated. Reply @mdostay @mdostay 1 year ago Trying to rectify the differences in opinion between Dr Sinclair and Dr Gabrielle Lyons with respect to the best protein sources. Incredibly frustrating when several credentialed and respected experts disagree on fundamentals Reply @andreazalewski7021 @andreazalewski7021 1 year ago Where can I purchase NMN in Australia? Reply @aussiecfo @aussiecfo 1 year ago Another beauty, lads! Reply @successfulperson3304 @successfulperson3304 1 year ago I was wondering why Dr. Walter Longo mentions breakfast as very important and David Sinclair does not. That eating breakfast has great benefits in the long run. What research says that? 3 Reply 5 replies @jeanawalter @jeanawalter 1 year ago How do you get Metformin without a prescription? Reply @matzefritz @matzefritz 1 year ago It is a myth that the mediterranian diet is just plant based. They eat lots of plants and spices ans so do I. BUT They DO eat meat on a regular basis. It seems to me that David Sinclair is part of a vegetarian cult trying to do science. In this case they communicate ideology. Otherwise I respect Sinclair and I think that most of his work has a sound basis. 3 Reply 2 replies @AppleyGirl5280 @AppleyGirl5280 1 year ago i can not for the life of me , convince my doctor to write a prescription for metformin ;( Reply @vladyslav743 @vladyslav743 1 year ago On the one hand lack of vitamins B leads to accelerated aging and heart disease, on the other hand, David admits that plant-based diets in most cases will result in vitamins B deficiency. So what's the point to say that it's good for longevity if it's not? 1 Reply 3 replies @lamouralice4533 @lamouralice4533 1 year ago May I know what is the relation of NMN & AMPK? Reply @bobbobsen4469 @bobbobsen4469 1 year ago When you talk about how protein from meats are bad. Would you recommend protein from whey instead, or is it the same case? 1 Reply 1 reply @snakeandturtleqigong @snakeandturtleqigong 5 months ago Exciting times! Reply @88Jenpal @88Jenpal 1 year ago Any recommendations on which NMN brand is best? Reply @paprikaveg405 @paprikaveg405 1 year ago Are there studies on the topic of converting AlAs into epas and dhas? Reply @ale52081 @ale52081 9 months ago It seems that sirtuins can repair broken DNA related to aging. Is it possible the same process for people with disabilities that not necessarily are old. I mean, a teenager with intellectual/developmental impairments? Reply @rocoHuana @rocoHuana 1 year ago folic acid is b9 not b12, b12 is cobalamin Reply @pureffm @pureffm 3 months ago Folic Acid is not B12, it is B9. But B12 is what vegans have to worry about, only available through Natto and some Algae for them! 1 Reply @hayleygreeneyes @hayleygreeneyes 1 year ago I would truly enjoy this podcast series more if Mathew was not apart of it. I find that he often interrupts David and that he directs the conversation away from what David is wanting to talk about. The original conversation between Sinclair and Huberman was much more informative and enjoyable. I understand that Dr Sinclair feels like he needs a co-host. I highly recommend that he continue solo in the future or interview other scientist in his field. Thank you! Reply @patrickday4206 @patrickday4206 1 year ago (edited) Sorry David but that beginning explanation of brain cell malfunction acting like a liver cell wasn't the best alzheimer's is a prion disease misfolded protein buildup coupled with decreased blood flow and other miscellaneous toxin build ups which I'm sure you'll discuss since I'm at the beginning 1 Reply @VictorSneller @VictorSneller 1 year ago Hey, he’s doing a good job man! Leave him alone! 6 Reply @spoudaois4535 @spoudaois4535 1 year ago (edited) Plant based diets are the healthiest because humans and other primates evolved to eat that way. Humans in particular are starch eaters. We have the highest amylase in our saliva of the primates. 2 Reply @jordanbowey4175 @jordanbowey4175 1 year ago As a kickboxer I'm terrified to watch this Reply @econdoc3000 @econdoc3000 1 year ago Seaweeds are actually the primary producers of EPA and DHA! Little fish do eat these and bigger fish eat little fish- this is why some of them are rich in these fats. Fish do not produce Omega 3! 1 Reply @diseasehealthdiets136 @diseasehealthdiets136 1 year ago Thanks!! 1 Reply @Vospi @Vospi 1 year ago 24:25 Folic acid is not b12, it's b9. It's not even b9, it's a precursor to it. I'm sure you just misspoke. Also, Pacman doesn't jump, not usually. 1 Reply @lauried4439 @lauried4439 1 year ago Vegans can get EPA and DHA from algae oil. Also, B12 is not folic acid or folate. B9 is folate. Thanks! Love the series! Reply @sandraslutz9489 @sandraslutz9489 1 month ago So I wanted to thank you and the company you co-founded for the FDA banning NMN in the USA. I guess that makes your book worthless. The regimen you recommend was Metformin, NMN, and Resveratrol. I understand that you and your company also tried to ban Resveratrol, but were unsuccessful. Seems pretty underhanded to me. Reply @kimberlyf4888 @kimberlyf4888 1 year ago Ok, let me get this. We should eat a mostly vegetarian diet, but then that makes us deficient in nutrients that both age us and can only be found in red meat. How on earth does this make sense? 1 Reply 1 reply @Dani-jo9yr @Dani-jo9yr 1 year ago Great ideas, but so not true about vegan: vegetarian diet: Mediterranean diet is full of fish and Meat! I know- I lived there😉Anyhow, I love the some of informations 👏 1 Reply @chriscorey1871 @chriscorey1871 1 year ago where do you get NMN powder in bulk that is high quality? Reply @MedusoidHumanoid @MedusoidHumanoid 1 year ago yayyyyyyyy you started your own channel!!!! 1 Reply @brendanbudniak2261 @brendanbudniak2261 7 months ago Thank you, guy from Alvin and the chipmunks, for co hosting Reply @johnmartinsen7623 @johnmartinsen7623 9 months ago Why are you afraid to have a conversation with Dr Paul Saladino? He makes some good points that you clearly don't want to acknowledge. Upton Sinclair said it best..."It is difficult to get a man to understand something when his salary depends on his not understanding it." Reply @AnkushSharma-zv5hv @AnkushSharma-zv5hv 1 year ago once more keep going Reply @richardlee4730 @richardlee4730 1 year ago David, do you color your hair? I ask because you are 52, obviously quite healthy but even so, it is rare not to have a gray hair on your head at your age. Reply @audreyhurley6248 @audreyhurley6248 1 year ago Love podcasts! But why do you keep bringing up Metformin- it’s not readily available has to be prescribed by doctor. Most doctors, mine included won’t prescribe if there’s no diabetes or pre diabetes. 1 Reply @pespsijackson3958 @pespsijackson3958 1 year ago curcumin activates sirt1 and ampk pathway and inhibits mtor 1 Reply @joetart9905 @joetart9905 1 year ago From Resveratrol Wikipedia... "Although commonly used as a dietary supplement and studied in laboratory models of human diseases,[10] there is no high-quality evidence that resveratrol improves lifespan or has a substantial effect on any human disease.[11][12][13]" So? 1 Reply 3 replies @tobytobykins3002 @tobytobykins3002 1 year ago I love this, but your sidekick interrupts you SO much! Dr. Sinclair it is frustrating that you’re frequently unable to finish your thoughts. Reply @judyfasola3737 @judyfasola3737 1 year ago Dr.would Nystatin and Dyflucan.....be ok to take with your anti-aging Protacal ...which I'm on...... also will your protacal help with thinning hair ... 72 years young lady ❤️ Reply @brotein3577 @brotein3577 1 year ago There are a few scientists currently dragging your scientific credibility through the mud because of your unyielding position on the life extending benefits of resveratrol, despite the most recent papers showing it not to be case. Will you be responding to those accusations and help dissect all the recent data? 8 Reply 5 replies @angelface2864 @angelface2864 1 year ago The Mediterranean a diet has well and truly been debunked in many research papers. So has plant based diet. If by definition a plant based diet deprives you of one of the most important brain health vitamins B 12 then this whole theory is called into question. Bioavailability of nutrients in plants is very low plus they are laced with anti nutrients. Then there are pesticides, GMO, poor soil quality, preservatives to prolong their shelf life etc. If the nutrients are not in the soil, the plant simply can’t make it. Georgia Ede Harvard psychiatrist speaks about the significant benefits of carnivore diet on mental and brain health. Sally k Norton is world expert on oxylates- the very damaging anti nutrient in plants like spinach. Also lectins. Gluten. Basically plants are designed to repel animals eating them as they cannot run away. Nothing in the world compared to the nutrition found in beef liver. See Sean Baker orthopedic surgeon on success of animal based diet. Reply 2 replies @walkrelax897 @walkrelax897 1 year ago David Sinclair looks like he is 25 and 45 years old at the same time... but... he is 52! 4 Reply 3 replies @sahilsharma8629 @sahilsharma8629 1 year ago Devraha baba lived for 250 years. Nangta baba lived for 300+years. Tatwale Baba stopped ageing at the age of 33 and remained same physically till he died 90. They were the masters of stopping old age. One more Prince of patiala who died when he was 180. Reply 4 replies @Michael-zl3je @Michael-zl3je 1 year ago (edited) Thoughts on cerebrolysin for brain health. Reply @haroldhart2688 @haroldhart2688 7 months ago THE BIBLE PROMISES IMMORTALITY AND TRAVELING THROUGH SPACE TO TERRAFORM DIFFERENT PLANETS AND BEFORE THAT THE OPPORTUNITY TO RULE THE EARTH. Reply @Darwini @Darwini 1 year ago David Sinclair - please respond to Dr. Brad Stanfield. Science is about constantly evolving data. If resveratrol is as valuable as a phytoalexin as you make it out to be, surely there should be no reason not to have a healthy discussion with another antiageing researcher right? I love your work and everything you stand for, but I'm afraid his constant berating is tarnishing your reputation the longer you let it go on. Either way great episode as always. 1 Reply @swimmingbird238 @swimmingbird238 1 year ago I would get the Sinclair anti-aging fart perfume Reply @Christina-tb4cp @Christina-tb4cp 1 year ago Why choose a vegan diet to live longer when deficiencies make you sick and live shorter? In meat and fat from animals, you find all the B vitamins and oleic acid you need. I think it is nice of you to share your knowledge, yes, but there is NO EVIDENCE that any human has survived long term on a purely vegan diet, let alone made humans live longer. Reply @saithrinay2678 @saithrinay2678 5 months ago Requesting for a job on resarch of immortality and increasing lifespan, i can work with dedication and effort even during non working hours of job as I'm interested in my goal of becoming immortal, education- B pharm + M pharm in pharmacology, age-26, gender- male, place- India country, Bangalore city, it's my humble request please consider me🙏. Reply @leonaowen9234 @leonaowen9234 1 year ago Ok her we go I had cataract surgery then dr lasered eye for blurred vision another dr found jel had come out from under the lense sent for eye surgery this dr REALLY messed my eye up. He did not get all the jel and I now have a oversized odd shaped pupil. He refuses to do anything and so far now other dr will do anything. My eye aches and I get headaches if in bright sun have to wear sunglasses outside. Reply @antonial8776 @antonial8776 1 year ago What about physically active people taking metformin? Isn't there an adverse effect? Reply @mpmrevolution @mpmrevolution 1 year ago inspiring Reply @Jmartestuesday @Jmartestuesday 9 months ago $10.00 Thanks! Reply @gabrielbotero1 @gabrielbotero1 1 year ago love it!!! take a look about olive leaf (Tea or extract) ....... better than olive oi it self!!!!!!!. Reply @HMD9997 @HMD9997 1 year ago Should I start taking senolytics in my 20s? Reply @evolvingx6504 @evolvingx6504 1 year ago folic acid is b9 not b12 1 Reply @OptimalLiving2.0 @OptimalLiving2.0 1 year ago I may be wrong but did he say that B-12 is folic acid or folate? I thought B-12 is cobalamin. Reply @imdiyu @imdiyu 8 months ago Magnesium saved my life Reply @gregrodgers3350 @gregrodgers3350 1 year ago Are they coming back or was that it for the podcast? Reply @BlueM3rcury @BlueM3rcury 1 year ago What is your opinion on Berberine? Reply @ciarog6116 @ciarog6116 1 year ago If you can check brain age for $1 in your lab, if and when you offer this to the public, how much will you charge us? Reply @drsekugathers @drsekugathers 1 year ago 💪🏽💪🏽💪🏽 Reply @bobann3566 @bobann3566 6 months ago 1:50 What is the difference between the Mind and the Brain? Reply @anitaflego4438 @anitaflego4438 1 year ago Can we get athletic greens in Australia? Reply @laurinhamilton1016 @laurinhamilton1016 1 year ago Do you think that metformin also might benefit things like Parkinsons? Reply @Hambastegy @Hambastegy 1 year ago 🙏😍❤️ Reply @swimmingbird238 @swimmingbird238 1 year ago Sinclair will have smooth glutes for Life Reply @HakuCell @HakuCell 1 year ago it can be dangerous to be in protein deficit Reply @guywaddington5358 @guywaddington5358 1 year ago Huntingtons disease, do you think NMN+resvertrol could help? @davidsinclair Reply @themelonsquadsubscribe @themelonsquadsubscribe 1 year ago what brand of NMN do you recommend? Reply @pespsijackson3958 @pespsijackson3958 1 year ago plant based diet and 17 hour intermitent fasting daily and curcumin daily 2 Reply @heavenhaven7254 @heavenhaven7254 4 months ago Like to see video of menopause cause sleep disruption and deprivation. Reply @emilee_7265 @emilee_7265 1 year ago omega 3 are a lot in Grass fed Products, no one say that, example Beef or Milch Grass fed. Or good eggs also. No plants Products are enough.... we are not born with suplemments..... so when Plant base Diet has not enought of so many nutrients, is it not good for us??? Thats logic for me..... Reply @melongai2902 @melongai2902 10 months ago Please can I have the metformine dosage/ initial Reply @123ChrisG @123ChrisG 1 year ago Please can you respond to Dr Brad Stanfield regarding resveratrol. He has made a few videos on this. Thankyou! 29 Reply 4 replies @tomballey8906 @tomballey8906 1 year ago Talk about your Resveratrol lab issue Reply @malikmatatv.1476 @malikmatatv.1476 1 year ago What about the night shift that only sleep in morning? Reply @Ant3_14 @Ant3_14 1 year ago What can average human do to help this research? Petition to politicians, funding research? Reply @fujchi2172 @fujchi2172 1 year ago An Anti-Aging Pill? Think Twice by Gretchen Reynolds, NYT, June 19, 2019. Is there still controversy regarding exercise and metformin use by people over 65? Reply @sofianchaybouti909 @sofianchaybouti909 1 year ago The discussion about alzheimer’s reminds me the planet of the apes: the origins Reply @rocoHuana @rocoHuana 1 year ago healthy 100 year olds please share your secrets here Reply @gwnbw @gwnbw 1 year ago Mhm Idk, it feels so much to take Complex Vitamin B supplements everyday and u never know when u have enough, tests are expensive and not accessible. Reply @chestercopperpot3793 @chestercopperpot3793 1 year ago Are you suggesting that people without diabetes go to their doctor and ask for a Metformin prescription? Reply @dominikd9834 @dominikd9834 1 year ago Something very worrying today. I've seen Dr. Brad Stanfield's video on YouTube and he says that resveratrol doesn't work. I don't know what to think anymore... please respond to his video and other people's claims about no real clinical trials about all this. 1 Reply @henniannariina5877 @henniannariina5877 1 year ago Folic acid is b9 not b12….. 1 Reply @xiaoyuvax @xiaoyuvax 1 year ago 27:24 Folic acid is absolutely not Vitamin B12 (Cyanocobalamin). Reply @mowthpeece1 @mowthpeece1 1 year ago Foods have NAD. CUCUMBERS have huge amounts. Google it. Reply @Cherryontop10 @Cherryontop10 7 months ago Is this why rich countries suffer and age and get sick more than poorer countries? Reply @mrhrg777 @mrhrg777 1 year ago My hero，would you think herbal medicine could be a new direction？ Reply @sillejuulkjaerbo4723 @sillejuulkjaerbo4723 1 year ago What you’re saying about DHA and EPA on a plant based diet is not true. There are excellent supplements with DHA and EPA made from algae! Reply @raystevenson2408 @raystevenson2408 1 year ago Where do you stand on cannibas use, smoking versus nonsmoking, cbd and thc etc.? Reply @andrewr76861 @andrewr76861 1 year ago Thoughts on intranasal NAD+? Reply 1 reply @Breakingtheglasswall @Breakingtheglasswall 1 year ago If you're vegetarian I would get your omega 3 from DHA /EPA algae supplements. Reply @bobann3566 @bobann3566 6 months ago 15:00 What is the difference between a quick wit and wisdom? Reply @MsCaterific @MsCaterific 1 year ago 💗 Reply @garyrobertson3645 @garyrobertson3645 1 year ago 💪🏼💪🏼💪🏼 👍. Reply @eyeandmind @eyeandmind 1 year ago Let’s go!!!! Reply @kenectd @kenectd 1 year ago What about taking creatine monohydrate for brain health? Reply @firstlast5322 @firstlast5322 1 year ago 💚 Reply @the_q_is5868 @the_q_is5868 1 year ago I'm not understanding what David said he takes for sleep. It sounds like "anumen" or "enamen" Does anyone know what this is? Thank you! Reply 2 replies @jawadkarim6615 @jawadkarim6615 1 year ago (edited) what about MCT oil like (coconut oil ) ! coconut oil is good or bad for brain ? Reply @starfox300 @starfox300 1 year ago hm Matthew has been looking a bit younger Reply @seppimweb5925 @seppimweb5925 1 year ago NMN is increasing homocysteine levels and bilirubin. This is very bad I guess. Why didn't you mention this??? Reply @bradstonestreet9940 @bradstonestreet9940 1 year ago Isn't that a reason intermittent fasting is recommended. Reply @falconone7230 @falconone7230 1 year ago I used cassette tapes in my 1996 vehicle until 2011 when I got my first vehicle with a cd 💿 player. I just started pairing devices for music in 2020. Lol I guess I've been sleep 😴 💤 😅 😴 Reply @chrisgmay16 @chrisgmay16 1 year ago He is FROZEN 1 Reply @niritfriedlander1751 @niritfriedlander1751 1 year ago I clicked on level’s link you share here but it says that the product is on progress..? Reply @tubo1812 @tubo1812 1 year ago The podcast is good but this one and all I listened to are too centered in NMN which is not available everywhere and that makes it less actionable. Reply @AnaAna-rx3yz @AnaAna-rx3yz 11 months ago None of the sponsors' links works!!! :((((( Reply @ricespiceandme8541 @ricespiceandme8541 1 year ago Plz if u wud make the vdo a little shorter it wud make it more interesting Reply @bejusu @bejusu 1 year ago (edited) Was counting down 😀 Reply @IamGroot-ln1nm @IamGroot-ln1nm 11 months ago Is taking fish oil every other is better than everyday ? . U said giving mice every other day the mice live longest what about Yourself y don’t u eat the same way? Or u do ? . Plus, also this way best for fasting n workout? So we should work out n fast the same day with taking resveratrol? . Cuz 3 of these activate stir1/ampk .the idea is should not activate stir everyday or they Reply @pw2035 @pw2035 1 year ago The content is interesting, but delivery rarely provides sufficient or succinct info for practical life application. Reply @veehope2702 @veehope2702 1 year ago Red wine red wine yeah yeah yeah, what about the alcohol in red wine? Studies now show there is no safe amount of alcohol. Talk about that. 5 Reply 3 replies @elidecantero5688 @elidecantero5688 1 year ago Why does he promotes AG but he doesn't takes multivitamins? 1 Reply 2 replies @Kingmurcer @Kingmurcer 7 months ago Thanks Reply @jamuga60 @jamuga60 1 year ago Can you take say Tru Niagen and resveratrol together................do they work in conjunction? Reply @ycc9369 @ycc9369 10 months ago This man looks as if he had a major trauma. Reply @riseup6112 @riseup6112 9 months ago This is what Huberman is doing ? Reply @Coatch-monir @Coatch-monir 1 year ago Thaaanks Reply @amyrorris569 @amyrorris569 11 months ago Algae oil for vegans to get omega 3s. This is what the fish eat! Reply @carlosponce605 @carlosponce605 8 months ago The interviewer needs to stay quitet a bit longer lol Reply @bostaurus1 @bostaurus1 1 year ago I feel like David nowadays talks outside his core expertise. There is very little new information and when there is, it does not seem to be true. Some clear mistakes, like folic acid is not b12... Reply @rager4able @rager4able 1 year ago So a little bit of wine is good? There are so many conflicting opinions out there, is why I ask... Reply @herlock736 @herlock736 7 months ago 32:20 wow Reply @pyyseta1410 @pyyseta1410 1 year ago Good Reply @eliana7937 @eliana7937 1 year ago Do survivals of wars tend to live longuer? Reply @StrongwillGameTheory @StrongwillGameTheory 3 weeks ago This chubby guy is giving me the vibe that he's half-assing his homework. Reply @KatheleenWaters @KatheleenWaters 4 months ago I feel sorry for the mice you torture with your lab testing. Reply @r91playsind @r91playsind 1 year ago Botox all the way! 1 Reply @lesliestyles8527 @lesliestyles8527 1 year ago What? B12 is not folic acid, that’s B9. B12 is Cobalamin. Reply @jamesfrith9869 @jamesfrith9869 1 year ago For the Alg boost Reply @FreeLeonardPeltierNow @FreeLeonardPeltierNow 1 year ago 🗣🎧 Reply @sahilsharma8629 @sahilsharma8629 1 year ago And also shivananda baba, he is 126 years old, fit and fine. India is the land of miracles. 1 Reply 5 replies @medcaresklep2676 @medcaresklep2676 1 year ago david don't read these ads. It looks poor. Outsource it to someone else or let advertisers provide graphics 1 Reply @BeaVizcarra @BeaVizcarra 1 year ago (edited) And God and Evolution said, “Sinclair we are done doing our work ensuring that human lives continue in the world. Please take over” 😂😂😂😂🤣 Listen, I’m happy to hear and take advice from this guy but let’s not forget we made this far without him. BTW not shaming him for it but also because I am scientist I have to say he has Botox all over his face. His hair it’s what impressive yet not sure if he colors it too 😉 But yes I am currently testing with resveratol and NMN as well as bunch of other supplements but remember people everyone is bias Reply @xiujhenwang1406 @xiujhenwang1406 11 months ago David Sinclair先生：您好！ 我是一真，中国人，住在纽约。 知道您研究的项目，非常兴奋，找到了知己。 我在很多年前，获得了【宇宙真相】，可以解释圣经中为什么说【上帝是道、是生命、是真理】 我研究中国的【黄帝内经】，明白了【经络是生命的自动免疫系统】、【宇宙就是上帝的身体】【宇宙是统全息，人体是微全息】、 我掌握了【经络存在的科学依据、经络运行的原理、利用经络自己可以给自己治病】 我坚信【衰老是疾病造成的，是可以自己医治的，人是可以保持青春与健康的】！ 我在中国大陆，有二个团队： 1，证明经络的存在，并利用经络自己给自己治病，治愈者成千上万。 2，经络运行原理，可以解释自然科学和社会科学中的一切疑难问题，可以消除人类分歧，真正获得和平 感谢上帝，带我来美国，成为【复活瑜珈教练】 治愈了很多人的病。 更加坚信，衰老是病，可以医治。 我在【嘻乐】视频中看到【一位沙特王子，17年的植物人，至今末醒，医院放弃治疗，但他的家人相信神会让他儿子复活。在那一时刻，神告诉我【你可以让他复活！】 我和Elon Musk在FB上交了朋友，他对宇宙真相感兴趣， 如果哈佛大学给我医治【王子复活】的机会，对推动健康产业非常有好处。 我给人治病，不要钱，只为了彰显主的大能。因为每次治病，都是主的启示。 希望和您取得联系 我的邮箱：xiujhen0803@gmail,com 谢谢！ yizhen Reply @winbalingit8502 @winbalingit8502 1 year ago 🤯!!!!!!!!! 1 Reply @dianehafner4350 @dianehafner4350 1 year ago Athletic greens have natural flavors---a known neurotoxin?? I don't see how y'all can rec.??? As well as stevia. I know you won't answer but maybe someone that reads this will. 1 Reply @frankasafscimone3920 @frankasafscimone3920 1 year ago I don't think it looks good to advertise a product. 1 Reply @malabikakulkarni7241 @malabikakulkarni7241 9 months ago Matthew guy is really annoying, keeps on interrupting. I tune myself out whenever he talks, but that way I found that I am losing part of Sinclair’s talk. Sinclair should control the amount of chatter Matthew is adding. Reply @benv.5170 @benv.5170 1 year ago Centrophenoxine Reply @jn052159 @jn052159 1 year ago with computers dna sequencing wheres the great discoveries...aint none Reply @YY6951 @YY6951 1 year ago B12 is NOT folate. What an embarrassing mistake... Reply @marilynking4003 @marilynking4003 1 year ago Statins are not good for the brain. Reply @prathutayade2218 @prathutayade2218 1 year ago :) Reply @yeye7559 @yeye7559 7 months ago WHY THE TUMBNAILS CHANGED? Reply @dannyrod1980 @dannyrod1980 1 year ago Can anyone participate in your studies? Reply @jamesburns2524 @jamesburns2524 1 year ago Too many ads. Reply @dym3nsions396 @dym3nsions396 1 year ago whats the youngest i can start taking nmn and resveratrol Reply @torosdemircioglu8095 @torosdemircioglu8095 1 year ago Videos are too long , you can Summarise like dr Eric berg ..it takes 1 hour but main things are just 10 minutes Reply 1 reply @extremekicksdotcom @extremekicksdotcom 1 year ago Doesn't Dave support getting vaccinated? Reply 1 reply @floraciarlo3978 @floraciarlo3978 1 year ago You look like in 1995....... 1 Reply @Ash-radio @Ash-radio 7 months ago the host talks a lot more than the dr. so irritating . 1 Reply @jayb8056 @jayb8056 1 year ago Please respond to Dr Brad Stanfield's video. Reply @Stefan-vc2ef @Stefan-vc2ef 1 year ago (edited) Folic acid is not B12 in case anyone was confused. I can’t take this guy seriously. Reply @tahellewythet @tahellewythet 1 year ago yeah but, can you wiggle your eyebrows? 2 Reply @Cindy24412 @Cindy24412 1 year ago The co-host isn't that great of a fit actually. Reply @durbanman @durbanman 1 year ago So at the moment only USA and Canada can subscribe Reply @cholakicha @cholakicha 1 year ago (edited) 50:00 Reply @user-oi1ly5bl5p @user-oi1ly5bl5p 5 months ago (edited) 18:33 Reply @alexmichaud3612 @alexmichaud3612 1 year ago Can i have back my lost memory 1 Reply @shaystern2453 @shaystern2453 1 year ago get a pro instead of this guy and shorten the time on these Reply @AnaAna-rx3yz @AnaAna-rx3yz 11 months ago (edited) Sorry I understand David that he is your best friend but he is pretty annoying!!!! Constantly interrupting you!!!! Reply @BlooTube1 @BlooTube1 6 months ago So these two guys are dating eachother. 1 Reply @mabelliu1 @mabelliu1 1 year ago Yeah!!! Reply @anonuser111 @anonuser111 1 year ago Your intro looks like you've stolen from Dr Huberman 1 Reply 1 reply @petercoderch589 @petercoderch589 1 year ago This interviewer is terrible. Not only is he unintelligent and asks dumb questions, but he talks way too much and in fact talks more than Sinclair does. This is one of the downsides of having communication grraduates doing these interviews. Brent Nally, I think, is another example of one of these communication majors doing interviews with longevity experts. They go into these jobs because they are "people persons" and like to work talking to people. But this is not what I want in a science interviewer. I want someone that knows roughly as much as the interviewee. This is why i like Peter Attia's podcast so much: even though I don't agree with Attia's metabolism-approach to ageing, at least he is intelligent, he does know a lot of physiology and biochemistry, and above all he lets his guests speak and doesn't interrupt them all the time. 2 Reply @pespsijackson3958 @pespsijackson3958 1 year ago 26:33 keto diet 💩💩💩💩 1 Reply @ehsanrezai1208 @ehsanrezai1208 1 year ago Hehe Reply @youremom5463 @youremom5463 1 year ago Pacman lol Reply @tonytiger3871 @tonytiger3871 1 year ago Hair color and Botox Reply @cryptscendence3421 @cryptscendence3421 1 year ago Cbd oil Reply @susanclasen4189 @susanclasen4189 1 year ago Pp) Reply @a.vaccarielli7637 @a.vaccarielli7637 1 year ago Are you the scam artist who stoled almost a billion dollars from GSK.? Reply #8 Lifespan with Dr. David Sinclair Biotracking, Age Reversal & Other Advanced Health Technologies | David Sinclair 272,527 views Feb 23, 2022 #8 Podcast Episodes In the final episode of this season, Dr. David Sinclair and Matthew LaPlante focus on current and near-future technologies relevant to health and aging. In addition to discussing the utility of wearable sensors and biological age measurements, they highlight innovative research aimed at : reversing biological age. The societal effects of therapies that successfully extend healthspan and/or lifespan are also considered. #DavidSinclair #Longevity #Aging Thank you to our sponsors: Levels - https://levels.link/sinclair Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Lifespan podcast website: https://www.lifespanpodcast.com Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsincla... Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclai... Stay up to date with David's work to democratize biological age testing and insights: https://www.tallyhealth.com Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante Timestamps: 00:00:00 Introducing Episode Eight: The Future of Anti-aging Medicine 00:03:49 Thanking the Sponsors 00:06:48 Modern Healthcare, Disease Detection, and Circulating DNA 00:11:30 Wearable Monitors: A Dashboard for your Body 00:20:31 Types of Health Sensors 00:24:20 Big Data, Privacy, and Criminal Investigation 00:30:16 Cutting-edge Testing and Biological Age 00:36:40 Using Personalized Data to Inform your Diet 00:41:48 Optimizing Exercise and Activity-mimetics 00:45:02 Resetting the Aging Clock 00:53:45 Repeatable Age Reversal and Safety 00:56:11 Longer Life, Population Size, and Economics 01:00:18 Skillbatical 01:03:06 Putting in the Work for Longevity 01:04:56 Thanking the Podcast Team and Wrapping Up Season One 01:08:27 Options for Subscription and Support Links: Affordable epigenetic age prediction: https://bit.ly/3nFeTto Waitlist for a new biological age company: https://www.tallyhealth.com Pharmacologically reversing age in humans: https://bit.ly/342XXGJ Restoring vision in mice via reprogramming: https://go.nature.com/335iysI Targeting aging is economically valuable: https://go.nature.com/3IgrQ4Z Please note that: Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be take or applied as a replacement for medical advice The Lifespan with Dr. David cinair podcast, its employees, guests and affiliates pplication assume no liability for the the information discussed. Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. Chapters View all Explore the podcast 8 episodes Podcast Episodes David Sinclair Podcasts David Sinclair 299K subscribers Videos About 1,393 Comments rongmaw lin Add a comment... @littlehouseinthebigapple5716 @littlehouseinthebigapple5716 1 year ago Oh, and PLEASE do a season two. There’s lots of us out here trying to figure this stuff out and the more data we have the more successful we can be! ✊🏼 579 Reply 16 replies @janinedodge5092 @janinedodge5092 1 year ago Absolutely do a season two!! Echoing Cassandra's comments: as a menopausal woman, I'd love to see a deeper dive into hormones and how HRT affects longevity. 35 Reply 2 replies @longtimelearner1402 @longtimelearner1402 1 year ago Season 2 is a must. With the rapid advances that are occurring, it’s important the information is disseminated and shared is a way that is easily understandable. And there is no better people to do this than you guys. Well done on season 1. 18 Reply 2 replies @danovic7822 @danovic7822 1 year ago (edited) Absolutely love this podcast guys!! I would watch every single episode even if there would be a hundred seasons. So yes, please do another season. 59 Reply 2 replies @mandeelaine1 @mandeelaine1 1 year ago Yes to season two!!! I think we need daily podcasts from you two. Absolutely life changing and I’m so deeply appreciative of the time and passion that you’ve dedicated to this cause. Thank you and can’t wait for more! 30 Reply 2 replies @moctin @moctin 1 year ago Awesome!! I loved every episode of this season. Really looking forward to season 2. I'm implementing alot of these suggestions in my life right now. Such as intermittent fasting, exercise, healthy eating, daily vitamins supplements. I'm now 43 and have osteoarthritis in my left hip. I was told its wear and tear from an active life of playing many sports. I was also told by doctors the condition is irreversible, but im determined to reverse it and eliminate the pain. I would enjoy a deep dive episode about inflammation in the body. I haven't read Lifespan yet but I will. I'm reading Life Force right now by Tony Robbins and it's mind blowing!! 46 Reply 1 reply @cassandrabrecht @cassandrabrecht 1 year ago As a menopausal woman, I'd love to see a deeper dive into hormones and how HRT affects longevity. 154 Reply 6 replies @erikaihasz9378 @erikaihasz9378 1 year ago Loved season one. Yes, please do a season two. An episode (or two) on inflammation in the body would be great. Also gut microbiome deep dive. There's a lot to learn about pre, pro and post biotics. Beneficial supplements (D, Omega-3, Collagan). 7 Reply @DarlySue @DarlySue 1 year ago Loving this series!! Please do a season 2! Would love a Q&A session with viewers like an office hours. 12 Reply @HOJUJP88 @HOJUJP88 8 months ago Hey guys! Are you planning on doing another season soon? I just finished all 8 episodes of the first season and am enthralled by the conversations you've been having. This is super interesting and extremely exciting. Can't wait to hear more from you Dr. Sinclair! 2 Reply @foznewloove2013 @foznewloove2013 1 year ago I really don’t know how many times I listen all the podcasts to be honest please keep going the world need you guys please, it’s very educational I can’t wait to hear more of you guys 1 Reply @Munksey @Munksey 3 weeks ago (edited) As someone who is going through a mid life crisis I really loved this series 😂. It's very positive and provides a lot of hope as someone trying desperately to cling to youth. I actually discovered it while trying to find more information on NMN. If you guys do a season 2, I'd be interested in hearing more about maintenance when we live in a world of extended longevity. For example, what will we do about tooth decay, tooth loss and gum recession. Will people who live very long have to just spend most of their lives with dentures or will we be able to force the body to regrow teeth? What about things like injuries where you have scar tissue or a hernia? Will reprogramming cells restore tissue into it's original form or will that maintenance often require surgical intervention? 1 Reply @drkaushikt6926 @drkaushikt6926 1 year ago Waiting for many more seasons to come, Dr. Sinclair 🙌 75 Reply @Ali-gl8ql @Ali-gl8ql 7 months ago For sure we really want a season two. These eight episodes was very useful and informative, thank you for these podcasts. 2 Reply @LEWNRC @LEWNRC 3 months ago Words cannot describe how valuable this series is and really hope you do a season 2, being a father im very interested in your position on protocol for optimal health and growth for kids and would love for you to talk more about it. Thank you so much you have changed my life Reply @JorgeMartinez-tr4hz @JorgeMartinez-tr4hz 1 year ago Several months ago I read Lifespan and was impressed and excited about what the future holds in this matter. I thank Dr Sinclair for his work and contribution to humanity. This first season has been a great complement, I hope they continue with their academic and informative work, we are all getting older and we need it. Reply @lucianowillemse8244 @lucianowillemse8244 9 months ago I am a PhD candidate in Biochemistry (with a special focus on nutritional biochemistry and metabolomics). I loved this podcast series. It has given me so much drive with regards to my study field. Can't wait for season 2. Reply @shawndawn1997 @shawndawn1997 4 months ago A second season depicting progress a year later would be awesome! Looking forward to hearing more from you guys. I just found your social presence but I highly appreciate your work! Reply @sebidsweiland @sebidsweiland 1 year ago I'm somewhat shocked to learn this already was the end of Episode 1. I was under the imagination that this was going to be a weekly podcast, like with Dr. Andrew Huberman. I loved the podcast, and I'm sure the longevity space really needs this one major podcast where people can come together, just like in many other fields. I urge you to continue! :) 54 Reply 2 replies @tegankrobinett1 @tegankrobinett1 7 months ago @David Sinclair we’d love more content focused on aging in females, hormone therapy and other female-specific protocols. thank you for your dedication! we’re lucky to have you. 1 Reply @FullThrottleTaco @FullThrottleTaco 1 year ago I've been following David's research and Advice for awhile- and this series has been great. I really hope there's a season 2. I feel like it clarified and grouped together a lot of information I had heard over the years. I really hope we'll see more- as my own efforts into the literature have been somewhat messy and disjointed. Reply @aignon @aignon 6 months ago Yeah, we want a season 2 with updated data & more info! Thanks David Sinclair. 1 Reply @maestrodimyan4311 @maestrodimyan4311 1 year ago Absolutely fantastic! Now you Have to create season 2 because of the responsibly you guys took once created season 1. People are in love with your work and science behind it. Please continue! A+++ 2 Reply @liza-ln3zl @liza-ln3zl 5 months ago just finished listening to season 1. WOW! Thank you Dr Sinclair and Matthew LaPlante for your knoweledge, discussions and encouragment to live healthier life! Please, DO SEASON 2 😍 Reply @alexismiller437 @alexismiller437 1 year ago Hi. I've been following Dr. Sinclair since 2015, have read Lifespan. I was wanting this podcast for years, so thank you. Please do another season. ...I and several friends have hypothyroidism and we're chronically under-cared-for, and I think under monitoring of our thyroid levels is a core reason. Q: Will there be continuous thyroid monitoring? I think this could significantly improve millions of people's lives both in health and subsequent personal and professional productivity. My potential has been significantly under-met due to lax thyroid health care. Thanks. 44 Reply 3 replies @jademail77 @jademail77 11 months ago Absolutely please do a second season!! I’ve learned soooo much from you all!! I’ve had rheumatoid arthritis for 50plus years but have done pretty well with years of eating healthy, supplements and wonderful alternative health care. Can you cover some chronic diseases and possible work to reverse them? I’d love to know! Thank you! Reply @ashields52 @ashields52 1 year ago The information you guys are sharing is incredible! Absolutely would be grateful for a season 2!! 🙏 Some ideas for topics: -Reproductive - fertility, pregnancy, breastfeeding, sex, etc. -Pediatric - what moms can do when baby is still in the womb to support their children’s longevity, baby, child, and things Dr. Sinclair does to support his children’s longevity -Meditation, stress management, & massage impacts on longevity -Centenarians & blue zones -Herbals, tea, & eastern medicine Reply @TheThrillerZone @TheThrillerZone 1 year ago My wife and I discovered this show while traveling cross country and since then I haven’t missed an episode. PLEASE do a second season. Your info is invaluable, you make the complex understandable, and it’s simply amazing. I for one (at 63) want to surpass 100 but only in strong health. Seriously, this is among the best podcasts out there. And trust me I host 2. Cheers. Reply @Ms13cats @Ms13cats 6 months ago Yes to a Season 2 and with you two guys specifically! Frankly I just love your voices. I can listen for long periods of time, it is very enjoyable at the same time as it is educational. Reply @lauriechapman7990 @lauriechapman7990 1 year ago Absolutely would love a second season, our medical system is generally too far behind to let us rely on them to keep us how to be healthy much less, teach us to age healthy! The current health insurance system also doesn’t encourage health so people need to take their health in their own hands and the information you provided was hugely helpful! Thank you again!! 3 Reply @popelgruner595 @popelgruner595 1 year ago Glad to hear that this is only the last episode of the first season and that you have at least a second one planned. I am grateful for this informative podcast. Thank you! 23 Reply 1 reply @prmft94123 @prmft94123 2 months ago PL EASE do Season Two! As a vital 85-year-old with a few health challenges, I am extremely interested in this podcast, and enjoy how both of you play off each other! After a youth of wanton debauchery (42 years in recovery from alcoholism), I made the decision to, rather than throwing caution aside and eating whatever I felt like eating and forgetting exercise, to completely change what I eat and exercise, stay socially engaged as much as I can even though my work (psychotherapist) is solitary and isolating and do what I can to increase vitality, energy, and well-being. Reply @cliveneel1737 @cliveneel1737 7 months ago You two are a match made in heaven, and you work so well together that you must definitely do a second season!! I am so grateful to you for all the information you have delivered so painstakingly 1 Reply @user-dk4ir7ll1p @user-dk4ir7ll1p 1 year ago Incredible episode guys! Please do season 2. You are doing an awesome job for humanity. Thank you very much David for passing on your knowledge. You are a gift from God to all humans. Keep going man! Reply @anotherusrname @anotherusrname 1 year ago Season 2 please!!! More on fertility sounds really interesting, maybe autoimmune diseases, and for sure more on any developments in longevity like this episode. Reply @elevatemindsmedia7657 @elevatemindsmedia7657 1 year ago Fantastic! I really appreciate and value the energy this team has invested and will continue to invest to providing quality information and science about health and aging. I'm very grateful for this series and am excited to hear you may make more! Thank you! 🙏 Reply @Malsbury1213 @Malsbury1213 1 year ago Love love love the series- thank you!! I’m a 71 year old healthy female and would appreciate hearing more about later in life age reversal- a deeper dive- what to expect- when is it too late. Also knowing that cancer cells are always circulating but not always a problem- can testing prematurely detect a problem ? 29 Reply @KaylaXiao @KaylaXiao 5 months ago (edited) Yes, please do season two. Very interested in fertility. Thank you for these informative and intellectually entertaining episodes! Awesome job! Reply @qihaicv6300 @qihaicv6300 3 months ago Hello David, I'm very, super interested in the restoration of vision. I'm doing all sorts of stuff to reverse aging, and the complete restoration of my vision I think will be the ultimate accomplishment. I vote for doing another series of 8 and covering more the vision stuff. I wish it was possible right now. Also, do another episode on skin care INCLUDING the neck, as in how to return the elasticity of that type of skin, and stuff like that. And lastly, another suggestion is that you learn the latest about Fahy's research and tell us ;-) Thanks. 1 Reply @lenakstudio @lenakstudio 1 year ago We all love what you do, so we are looking forward to your next episodes. Fertility is definately an interesting subject. 12 Reply @carpedium168 @carpedium168 8 months ago David, please continue the series. Very educational and has helped me, my family and friends focus more on what we can do to improve our health. Reply @DianeandGeorgeExplore @DianeandGeorgeExplore 1 year ago (edited) Fantastic series! Looking forward to season 2. Can you please discuss how close we are to creating heart valves using a person's own stem cells? And can you recommend someone who is currently doing this work? 1 Reply @francetrudelle @francetrudelle 1 year ago Love this podcast. Intelligent, coherent and comprehensive content ! Please don't end it !!!! Will keep my fingers crossed to see more ! Thank you so much for this amazing info. :) 34 Reply 1 reply @PattyRichardson1 @PattyRichardson1 3 months ago Please do another season!!! You are sharing invaluable information! ! 👍 2 Reply @arbiter3297 @arbiter3297 11 months ago One of, if not THE best educational series that I have encountered. You all have my abundant thanks for the great work that you have done here and of course the work you are doing in your research and enterprises to make life better for us all. Reply @EdLanceinSD @EdLanceinSD 1 year ago Yes please do season two! I did the inner age test, I would love for you to do an episode where you break down the inner age factors and what it means from your point of view. Reply @Anna-qz6xw @Anna-qz6xw 1 year ago You are my biggest motivator, dr. Sinclair! Can’t get enough of your lectures. Can’t wait for the new episodes! Reply @JMSsssssss @JMSsssssss 1 year ago This was fantastic, and i would love a season 2. I would also love to hear about the impact, if any, on autoimmune disease, and more indepth on menopause in the case of "severe" post menopause symptoms, beyond the ordinary hot flashes. There are a lot of us out there. Reply @whoah567 @whoah567 1 year ago For future episodes - would love to see a discussion on the microbiome. 69 Reply 4 replies @julielinkus2392 @julielinkus2392 7 months ago Hi David I'm very interested in a second series. I have watched your series over and over again. I am a prior biology major and my undergrad and it makes me consider going back to a biology based master. I have older friends that are interested in having children who never did so a topic on possibly reversing fertility would be amazing. Yes please please do another series Reply @jendunham6776 @jendunham6776 1 year ago Loved listening to this podcast. Definitely do a season 2...keep us up to date on all the many new technologies/supplements etc. rapidly being developed and how the average person can benefit. Thank you guys... Reply @kensley3049 @kensley3049 1 year ago You guys have to do a season 2. Please please please. Can't imagine a week now without learning from the best of the best. Thank you for all your hard work in putting this season together. Very grateful for all your knowledge sharing. Reply @anpole @anpole 1 year ago I learned a lot in the series and beg you to please do another season. Thank you for sharing this great information, now I'm not only taking the supplements, but also exercising and taking care of what I eat. Thank you guys for helping us improve our lives. Looking forward to the second season. 1 Reply @catherineslavin7324 @catherineslavin7324 1 year ago As an almost 70 year old, this information is so helpful. The work you're doing is vital to people and will help all of us to remain healthy as we age. Please continue the series with deeper dives and to relay new information as it comes to light. Thank you so much for taking the time to make this information available. I'd love to see your analysis of studies on this topic. 32 Reply 1 reply @emmanuelruiz488 @emmanuelruiz488 1 year ago It’s incredible the work that Dr.Huberman and you do, providing society with so much useful information ! Reply @marinatutino6511 @marinatutino6511 10 months ago Ohhh yes PLEASE do a season 2 can’t get enough!! So much amazing information. Thank you 🙏 Reply @TeresaBelcher02 @TeresaBelcher02 1 year ago Yes, I would love for you to do a season two. I have followed Dr. Sinclair for years. I want to thank you for your efforts and congrats on your success! Reply @ivyfeenix @ivyfeenix 3 months ago Season two please! I’d listen to this podcast DAILY! 1 Reply @khashayarafshar2548 @khashayarafshar2548 1 year ago Would love to see this show continued! Thank you Dr. Sinclair, colleagues, and sponsors for the health-saving tips! 5 Reply @creightonfreeman8059 @creightonfreeman8059 1 year ago Yes. Do another series. Actually it would be great if the podcast became an ongoing podcast. There are plenty of biomedical topics to discuss, and if you get tired of talking about your work bring in some of your colleagues and discuss their research (George Church, Steve Horvath, et. al. ) 11 Reply @nanjohnson6904 @nanjohnson6904 1 year ago Amazing information that has totally changed how I approach life. I listen/relisten nearly daily for motivation. It’s so exciting to hear the advances being made in these areas. There are too many poorly-aging folks who are sitting in nursing homes and breaking my heart. I pray our futures look different! Keep it coming! Reply @skyrider4789 @skyrider4789 1 year ago Hello David and Matthew. Thank you for this and I hope you're both well. We want MORE!!! Please. :) 1 Reply @paprikaveg405 @paprikaveg405 1 year ago This episode was my favourite, the positivity about the future ahead and the options to use all of this valuable life extension for the benefit of human population was really well put. Hopefully it will work as planned :) Reply @martinfilsinger1001 @martinfilsinger1001 1 year ago Please do a second season. You are presenting scientific facts in a great way. As a suggestion, please address the topic microbiome, gut health (restoration) and nutrition resorption as an addition to the episode on how and what to eat. Thanks for the great work and sharing this information! Reply @c.m.7128 @c.m.7128 1 year ago Please do a season 2. I have learned many amazing things from your show! Definitely a must watch! Reply @canal47100 @canal47100 1 year ago Please do a second season!! This is great- I feel very optimistic about our future thanks to Dr Sinclair, his work, and the efforts he puts into sharing it in a way everyone can understand. Please include female reproduction in a future episode. I cannot wait. Thanks again, fantastic show! 12 Reply @patriciastark7292 @patriciastark7292 1 year ago Please continue! We need this kind of wellness information. I tell everyone I know about your podcasts. It deeply saddens me when I see so many overweight adults and children that are ill or will become ill as they age due to lifestyle and diet. We need education to learn how to take responsibility for our own health. You are doing us a great service! Thank you and carry on! Reply @user-ig7ld1mh4i @user-ig7ld1mh4i 2 months ago Please do a second season! This information is SO valuable! Reply @georgeevancho9359 @georgeevancho9359 1 year ago Please do a season 2. I would love to hear more on red light therapy. 20 Reply @GoneWithTheBlastWave @GoneWithTheBlastWave 1 year ago Yes, please continue with a second season! I love sharing your podcast with friends and family. It has lead to great conversations about health and life. I had a great time talking with friends about mailing poop in the post. It was a great highlight of my day (I still giggle thinking about it)! Also, I am always on the lookout for whereever your work pops up next. Any interview, podcasts, or book appearances goes to my watch/read list. (I am a big fan)! Thank you for bringing your enthusiasm, critical thinking, and hope to the arena of health and longevity! 5 star review from me! May Lady Fortune and the Sisters fates bless you and your family! Reply @merilynliddell3690 @merilynliddell3690 1 year ago Hi David, I am a woman of 73 in Australia. I started following your work from the Lifespan book. I am trying to use the basic ideas in my daily life, and I am sure it is helping. The podcasts have been really fantastic as an update. I really hope you continue into a second season - despite my medical background I find it very difficult to follow the research without someone like you to bring it together in an accessible way. In season 2, I would love to hear where things are at in terms of fertility? Is anything known about suitable supplements for 40+ women trying to conceive? What about with IVF? I would also like to know what is and is not available for ageing in Australia (and potentially other countries than the US). Are any of the monitoring arrangements available in Australia ? How would you go about finding a clinician who is abreast of these developments, so you can get personalised advice using the available monitoring? But honestly, whatever you wanted to cover would be of great interest to me . It is a fantastic resource, and I do hope you continue. Congratulations. Reply @vickydaisy1905 @vickydaisy1905 1 year ago I’m looking forward to hear the 2nd Episode of your podcast. Here are topics that need to be considered; female fertility and menopause, SIRT6 activator, Apigenin supplements and Ca-AKG. Thank you 😊 18 Reply 1 reply @heinousanus9352 @heinousanus9352 1 year ago (edited) Dave's the kinda guy you want in charge of everything. Yes season 2 please. 👍 Reply @richardy4828 @richardy4828 1 year ago Wow! After this series of 8 podcast, I'm caught up with latest in life extension biotechnology. Thanks a million 😊 definitely please continue these very informative series going and keep your followers up-to-date. Reply @omarsanchez5972 @omarsanchez5972 1 year ago We the people need season two Dr. Sinclair. I want to thank you for sharing your knowledge with the public. Between you, Andrew Huberman and Lex Fridman I see you guys as role models and mentors which have inspired me to take action in my live and try to live to my full potential. Dr. Sinclair keep up the great work the world could use more people like you. Thank you. 5 Reply 1 reply @RoedhamHouseRanch @RoedhamHouseRanch 1 year ago I have to say...you two make an exceptional team! You both compliment each other not only in the information you present to us but also in the way it is presented. Now I'm no scientific person, nor do I work in any medical type field but you make this information so easy to understand! For years my experience with doctors has been lacking and its hard to know where to go when you want answers to questions they're not asking when it comes to your health. We've always been told "don't diagnose yourself" but at times, we have no other option because Doctors don't know everything...how could they? And they don't know each of us in such a way that (nor do they have the time it seems) they can help BEFORE you have an ailment. Good doctors are hard to find...great doctors aren't taking new patients 🙄 So... I WILL self monitor my health... I will self evaluate my health (not diagnose)...and I will educate myself (like listening to these podcasts) so that I won't be a burden to my family as I age (am 62). My father passed quite suddenly from gall bladder cancer which was discovered during what was supposed to be a routine gall bladder removal. The cancer was not diagnosed. He only lived for 2 months after it was. He was 72. My mother passed away from dementia. From the first signs we saw, she suffered about a year and succumbed brutally fast. She had been going to various doctors trying to find out what was going on with her but had not been diagnosed until it was too late. She was 79 when she passed. It scares me and I'll be brutally honest... I don't want to go like that. Nor do I want my children and grandchildren to remember me going like that. We so need to take our health into our own hands! Thank you for helping us along our journey. 🙏😊 1 Reply @deejays93 @deejays93 1 year ago First, thank you for this series! I feel much more in control of my health. Second, PLEASE do an episode specifically on Alzheimers. During this episode you guys made two comments that left me very curious. My mom is in advanced stages of AD and I now live in fear for my sister and myself, which I know is not healthy! Please consider disease specific episodes. Thanks again! Reply @catsteinhilb2880 @catsteinhilb2880 1 year ago Truly appreciate his entire series, thank you so much . I know one person who’s life has literally changed in 3 weeks after I shared a few episodes ❤️ 4 Reply 2 replies @qtyrubnvfm @qtyrubnvfm 9 months ago (edited) yes pls bring a 2nd season! I have learn so much from your podcast, Thank you Dr. Sinclair and Mr. LaPlante 1 Reply @mashantha @mashantha 10 months ago Would love to learn about aging and its impact on female bodies including reproduction. Most women across the world are told that they need to have kids by a certain time which adds to a lot of pressure and tough trade offs. Thanks for this incredible series of podcasts! Reply @SrNutritivo @SrNutritivo 11 months ago Looking forward for season two, guys. Great job, and thank you for doing this! I’m already changed my diet, taking most of the supplements, and exercising much more often and vigorously. The cold part is the toughest tho. Any tricks? Reply @chrisalmighty @chrisalmighty 1 year ago We would love season two indeed. This is a game changing breakthrough Reply @gyopik @gyopik 1 year ago Thank you so much for this series and also for making it available for free! Please continue this amazing work and keep educating us also. Among other topics I would love to learn more about aging in relation to pregnancy and the number of pregnancies, aging and the effects of breastfeeding, hormonal contraception and aging, child nutrition and healthy life setup for children. Thank you! I am watching each episode again and reviewing the notes I took. Reply @neoluyor9207 @neoluyor9207 1 year ago Not only season two, I think you should do it regularly and never stop. Many thanks for all your efforts 👏🏻 3 Reply @owambocontrol4218 @owambocontrol4218 10 months ago Loved all episodes of the podcast. so many practical advice, really well explained and two very charming hosts. Please go for a season two! Reply @KeredB94 @KeredB94 6 months ago Absolutely amazing season gentlemen. I would love to see an interview with Atul Gawande in season 2 and hear a conversation about extending lifespan and healthspan and their implications on end of life procedures and dying. He covers these topics at length in his book “Being Mortal”. I would imagine as the population starts living longer and longer death will become a somewhat complicated topic. Reply @franconero585 @franconero585 11 months ago finally! someone's doing what needs to be done!! I'm so looking forward for season 2! THANK YOU for all you're doing! Reply @beg5043 @beg5043 1 year ago Love the podcast, and hoping for season 2! I would love to know more about how to lower low grade cronic inflammation because many suffer from it and it causes so many issues that could shorten life like heart disease and cancer. 1 Reply @normamannix9779 @normamannix9779 1 year ago Absolutely continue with Lifespan Season Two! I have learned so much, applied some suggestions, and am working on applying more! Thank you, David, Matt and Team! 2 Reply @MilNORtop10 @MilNORtop10 1 year ago Would love a season 2! 12 Reply @AdelaandJude @AdelaandJude 11 months ago As an aging (64) - person, NASM Personal trainer and former Bicycle Racer, I found your series extremely informative and enlightening. As someone who has always delved deep into Pubmed to inform myself - Your series has really been great, and I look forward to another - 2nd season! Reply @karenlugossydesjardins6696 @karenlugossydesjardins6696 1 year ago Please do another season! So grateful for this information and your work 🙏🏻 Reply @mayra838 @mayra838 1 year ago Please do a season two. Thank you very much for all the education I received. Reply @user-zx1so4rv5c @user-zx1so4rv5c 1 year ago This series is just amazing. I will be really looking forward to season 2. Reply @barbaraloveless4261 @barbaraloveless4261 1 year ago Thank you so much for all the work you do! Please do a season two 😁 Reply @jalilmloukhiyeh4835 @jalilmloukhiyeh4835 1 year ago Another excellent episode and great way to end this series. Can't wait for future episodes where you actually announce trial results and actually make recommendations on actual suppliments/meds that work best at extending healthspan!! Thank you for you contribution to humanity! :) 8 Reply @bambooinchina @bambooinchina 10 months ago We definitely need a season 2. I feel much more enlightened, thank you. Could you include some info on Lectins & their effects on health/nutrition please. Reply @tomasanthony559 @tomasanthony559 1 year ago David and Team: Thanks for this series and especially the message at the end: When our parents are healthy and given the science to make decisions to live rich and longer lives, they can provide insight for us, as their children, to impart knowledge and make better decisions. After reading and following the work in the field for many years, I appreciate your time in making this series. Would also like to hear your thoughts on the following given the challenges we face today as a society where a large number of people deny the importance of the scientific method or science overall. How does your team view this work in the larger context of society? What about the mental health of individuals and communities? Would you agree that it seems at times that a large portion of the United States population seemed to be suffering from irrationality in their denials of science? Or that the pandemic exposed that weakness of education due to the fact that many people were and are easily manipulated in dangerous and destructive ways? What are the ways you think we can counter propaganda, lies, and non-scientific ideas to prevent the premature death of hundreds, thousands even millions of people? One could argue and suppose that Darwinian evolution works across all levels of human existence - but that would be callous and untrue. How can we fight these forces that harm our society as a whole, put us all at risk, and limit the ability to fund important science like this? If our goal is to build and produce rational thinking humans, and maintain a functional society that believes in science, what can be done better to promote and educate people on all levels so that they can make better, more informed, and science based decisions on their health? How can leaders in their fields (like yours) work to overcome the manipulated fears of these everyday people whose ignorance is being preyed on for profit or political gain and putting everyone at risk? How can we raise a healthy generation of science believers that ensures that as human beings we fulfill our potential for good as a species for every living thing and not just ourselves? I realize these are big questions but your work provides the timeline for each us to answer them and solve them no? I hope so! Best to you and your team! Reply @vadymkodryan3974 @vadymkodryan3974 5 months ago Thanks for season 1.I enjoyed it tremendously and I am making adjustments to my lifestyle. Definitely there is room for season 2. Among the topics I would love covered are: 1) any other useful supplements for longevity (carnosine from Greg Fahd, pterostilbene, and others; 2) more discussion of water fasting, intermittent fasting and longevity diets; 3) more discussion on hormone replacement therapies; 4) any cancer prevention herbs like astragalus, medicinal mushrooms, etc; 5) any great books you can recommend on various aspects of longevity-enhancing practices. Reply @tykenny1249 @tykenny1249 6 months ago Yes, definitly wanting a season 2! Great work guys. Reply @susangrady2072 @susangrady2072 1 year ago Thank you, David and Matt - so fascinating and hopeful for all of us for today and the future well-being. Getting my bloodtest tomorrow for InsideTracker! Reply @purity_kimani @purity_kimani 1 year ago (edited) Please record season two! Super interested in hearing all about fertility and aging! 4 Reply @michellechang2538 @michellechang2538 1 year ago I have watched all 8 episodes of this talk, i have to say that it's been an eye opening and educating shows, it gives people hopes and direction towards the healthier and longer lives. I'm so excited to share this informations with my physicians and friends.....thank you very much for Dr. Sinclair for sharing your knowledges and passions !! Reply @carlonharrington @carlonharrington 11 months ago I would love another season. This is very entertaining, practical, and useful. Reply @littleefizz @littleefizz 1 year ago Thank you guys so much for doing this. David, you are doing the most important work on the planet, you are a hero! 1 Reply 1 reply @TheStevenDo @TheStevenDo 1 year ago I’m all for season 2! The content is invaluable!!! 1 Reply @trinakling8399 @trinakling8399 1 year ago I really love this series!! Please do a season 2 and many more after that! Reply @cathylavoie @cathylavoie 1 year ago That season was very interesting: giving exxxxcellent and accurate information. Please keep going with your awesome job (both of you and all of your team). So nice to be informed on the new development in this field. Thank you for doing that. I REALLY appreciate you. 6 Reply @ktdoyle3004 @ktdoyle3004 10 months ago Absolutely loved this series! Thank you, thank you, thank you! I’d love to learn more about menopause and post menopause and how to best support myself and my body systems into the future! Thank you again! Reply @loisenglund8842 @loisenglund8842 1 year ago Very informative and helpful to those of us "regular" people who hear so much controversial info. Please do a season 2! Reply @Greg-su8nu @Greg-su8nu 11 months ago What an amazing journey. Thank you for posting, sharing info and studies and getting so many of us involved. Should be an interesting and amazing adventure. Reply @costelcorbuleac8698 @costelcorbuleac8698 1 year ago Thank you! It would be great to have a season 2. One great topic, at least for me, is to know the relation between aging and muscle building, as I feel like those contradict on their use of mTOR Reply @Nicstarmoore @Nicstarmoore 1 year ago 1 in 8 couples has issues getting pregnant. Infertility and premature ovarian failure are incredibly common, and the root cause is our accelerated and disproportionate aging. Yet there's so little information out there that can genuinely help women navigate this issue. Please, please cover this in Season 2, and thank you for the info shared so far. Personally, it's helped transform my own infertility treatment plan. Reply @jonahalldors5488 @jonahalldors5488 1 year ago Please do the season 2, I absolutely love your episodes. thank you for sharing this amazing information Reply @jatava00 @jatava00 1 year ago Absolutely loved the series! I definitely would like to see more! It's funny how doctors, nutritionists, fitness professionals etc have always told that eat every 3 hours and concentrate on protein intake. And yet you should avoid that. I've debated these things a lot with my friends and the wife. They don't believe anything I try to tell them =D Reply @voolproov @voolproov 1 year ago This was terrific. I sincerely hope you will expand on these topics in a future series. Highly anticipated! Reply @EmmettFlo7 @EmmettFlo7 1 year ago Season 2 please! I read your book. Supplementing what I learned with this podcast is great! Reply @MrRomantheGreat @MrRomantheGreat 1 year ago I loved this first series!! Please do a season two! As a 51 year old woman who is about to climb my first 8K m mountain in August (who has had to wait for 2 extra years thanks to Covid), every day backwards is a huge win! :D I have found that reading both your book and current literature, and now watching your podcast is the best way for me to assimilate all of this information. Thanks for creating a medium for us audio/visual learners. Reply @josephsiwek4324 @josephsiwek4324 1 year ago Awesome first season Dr. David,yes plz to season 2 bring your dad on for an episode. ALSO deep dive on microbiome. 8 Reply @kristenmcmanis8933 @kristenmcmanis8933 1 year ago PLEASE, PLEASE, PLEASE do a season 2. It never occurred to me there may not be another season, and it definitely got my anxiety going 🤣 Reply @raycerobinson @raycerobinson 1 year ago I have been sharing this podcast with a lot of my friends, this info is extremely useful, you guys lay it out in a very concise and clear way definitely definitely do a second season. 3 Reply @Fritz.program @Fritz.program 1 year ago This podcast has changed my life in many positive ways. I can’t wait for season two!!! 3 Reply @mb9389 @mb9389 1 year ago You definitely should do season 2, by all means! There are so many topics you guys will not run out of and we are more and more curious. Even with more data coming out, I hope you will keep us in the loop. Reply @OllieKubrick1 @OllieKubrick1 1 year ago Definitely want a second season - you guys are truly changing the world for the better. Reply @basiapio4765 @basiapio4765 1 year ago Thank you so much for taking the time to do this podcast! It's invaluable and life changing! Please do continue! I'd appreciate a deep dive into microbiome, IBS and brain-gut link. 1 Reply @aliciab4236 @aliciab4236 1 year ago Hoping for season 2. This first season has been brilliant. Thank you for the effort the team put into sharing actionable science with those of us who are not scientists. Looking forward to my first shipment of Athletic Greens. Reply @thatchessguy7072 @thatchessguy7072 1 year ago I’d be interested in a series similar to 2 minute papers (a YouTube channel) where David talks about his favorite paper(s) of the past week or month relating to aging. 5 Reply @joyaf.5121 @joyaf.5121 1 year ago Couldn’t wait for this podcast to start and it didn’t disappoint! Loved Lifespan and really appreciate your work at Harvard, your other company’s research, your commitment to the science and spreading the word for the good of society in the future. I’m now committed too and will help spread the word/podcast/book so more will join us. The potential topics for Season 2, 3, 4, etc. are limitless. Reply @belindamayson8670 @belindamayson8670 1 year ago Thank you so much for this podcast. Looking forward to another. I am 73,type 2diabetic,a heart patient with pacemaker,hypertensive,but listening to you gives me hope that I can reverse my age and live to my 90s,healthy if I do the things you suggested for longevity...isn't that great to look forward to❗👏 2 Reply @MsAdo1 @MsAdo1 1 year ago Thank you for an interesting season. I still hunger for more insights into research around hormones and the implications on later-in life changes (obviously with longevity in mind). I am female and in the middle of menopause - what would happen if I instead of taking estrogen, which as you pointed out are linked with breast cancer, took some androgens? And what would happen if a woman stopped ageing in the middle of her menopause? Would she be stuck there, treating symptoms and not feeling "balanced" for want of a better word? Also, I am glad you mentioned the difficulty finding brands that are trustworthy and or recommend the right dosage etc. So far I have only found NAD+ supplement suppliers, and no companies that sell NMN that I have any chance of vetting. Maybe you could discuss ways of easily getting recommendations of purity and dosage for veed brands etc? 1 Reply @rando-me2370 @rando-me2370 1 year ago This is among the most exciting and inspirational series I’ve ever watched. The Lifespan book was excellent (and inspiring) and I’m on the edge of my chair waiting for the next thing you guys do. Thanks. Reply @LowkeyFish @LowkeyFish 1 year ago Absolutely love the podcast David! I watch every episode! Some even multiple times lol. I love everything about what you are doing for the medical field in it's entirety and I wish you the best of luck in all your future endeavors. Much love and sending good vibes your way :-) 2 Reply @ANuts223 @ANuts223 1 year ago Yes, please do a season 2. This is fascinating stuff—I’m 31, active and constantly trying to optimize my health as well as my friends/family and your guys’ info has helped in so many ways! Thank you Reply @romanrubtsov3783 @romanrubtsov3783 1 year ago (edited) Thank you for making such a great podcast. Implanting these ideas into the daily routine helps to maintain the right balance in life. It would be great if you decided to make the second season. Among the topics I would be glad to see: "sleeping routine", "memory boosting", "cognitive exercises", "the role of stress for health in generally". What helps me the most in keeping my diet is my studies and the understanding that I am doing something useful for me, my family, and, further, I hope, for the society. I think that if you see the meaning in what you are doing, the new habits are implemented rather easier. I think that people struggle a lot with changing the diet not because they have not enough will-power (it is rather abstract, to my mind), but because there is not much in the life that supports this will-power. What could possibly support it? This is sadly a matter of some different podcast, but it would be great if real scientists did it, science-based as good as this one. Reply @joehahn8519 @joehahn8519 1 year ago I absolutely loved your Season 1 series for improving society's lifespan and the quality of life from birth to the end of life! This is amazing progress that will impact everyone and their loved ones! This provides hope to families who have a loved one who has alzheimers/dementia, heart health issues, pulmonary issues, or cancer etc. There is also the mental health issues like depression, PTSD, ADHD, or autism. Then there are children and adults who have low self-esteem because they have turned grey or balding before they were 30 or 50 years old or they have bad achne or a form of dermatitis. Many seniors suffer from age-related macular degeneration and eventually lose their driver's license and their independence. There is so much that can be done to improve the quality of life for people of all ages while resetting their biological clock. Thank you for the work you have done and the work that will be done as a result of your efforts! Reply @lisaduffin2734 @lisaduffin2734 1 year ago I would love a season 2! Would love to have this information in written form as well for reference. Thank you for your work and how you are making the world better by sharing your knowledge! Reply @sparkletooth @sparkletooth 1 year ago (edited) Loved this podcast series. Thanks for making it available for free. Would definitely be interested in a second series. Maybe it's not in your wheelhouse but I would like to hear more about stem cell research in relation to spinal cord injuries. I bought the book for my mother and my uncle who is paraplegic. On NMN supplementation, we should get a full health check up and make sure we have no cancer cells present before taking it, right? Reply @krishnamohan3301 @krishnamohan3301 1 year ago Thank you very much for a fantastic first season Dr. David Sinclair and Matthew LaPlante!!! I have learnt so much during these 8 episodes. I have already read your Book Life Span and have been fascinated with the science and research going on in Aging and aging healthily, so that we are not a drag on ourselves and others as we age. Looking forward to the next season😊 Reply @Botanifiles @Botanifiles 1 year ago (edited) I love the dynamic of your guys relationship, you can tell your total bros, and your differences in personalities compliment each other to make this an awesome, informative, and productive talk, while also being incredibly entertaining and a joy to watch and listen to Reply @HardForking @HardForking 1 year ago Best podcast there is, will be one of the biggest in quick time, keep it going please. 10 Reply @johnniekemp @johnniekemp 1 year ago Dr. Sinclair and Matthew Laplante, Great podcast explaining the most exciting area of research: longevity and vitality! Very inspiring to all us biohackers who are embracing upleveling our health. Looking forward to season 2! Reply @uriahz @uriahz 1 year ago Absolutely love this series and I hope to see another season. Reply @ExbotHero @ExbotHero 1 year ago (edited) Love this series guys. 👍Please keep the videos coming. 😊 We all need more in-depth knowledge on basically all the topics you have been talking about. That's literary thousands of episodes if we break it down piece by piece.🥇🥇🥇🥇🥇 17 Reply @nikitagolubev1851 @nikitagolubev1851 1 year ago Please, do a seson 2. I really need to have the proven data on what parameters put most attention to. Since, monitoring is not that well developed and accessible in 3rd-world countries, but blood tests are. And I think it will be useful not only for me. Reply @HarveyCastroMD @HarveyCastroMD 1 year ago This is great!!! I hope you guys do another 8 this spring :) David Sinclair Reply @thiamae5914 @thiamae5914 1 year ago Excellent podcast! YES to Season 2! 🙌 1 Reply @margarethogan3551 @margarethogan3551 1 year ago Love this podcast. You are imparting your gift of enthusiasm for the future. Thank you for working to make the world a better place and for generously sharing it in a form that is entertaining and can generally be understood and acted upon. I’m sorry that there are no more episodes. There is so much more that I would like to know Reply @liliapandova6545 @liliapandova6545 1 year ago Hello! Appreciate your work and please, do a season two. I'd love to see an episode about hormones, how they affect longevity and what we can do about it. Thanks! Reply @tericlark5446 @tericlark5446 8 months ago LOVE these podcasts!!! PLEASE do a season two!! Reply @matildebagnoli4893 @matildebagnoli4893 1 year ago Please, do another season. The information you are sharing is extremely interesting. Please keep us up to date. I found the conversations about the ethic implications of biometric data collection most useful. Thank you. Reply @bethdean8563 @bethdean8563 10 months ago Absolutely love this and love learning from you! Would love to hear more about topical exosomes and Biologics. Keep up the amazing work! Reply @jodihoyle2297 @jodihoyle2297 1 year ago I would love another season also! Thank you for using terminology that I can understand and is relatable. 4 Reply @susifeast4548 @susifeast4548 10 months ago Absolutley fantastic. I learned so much and even as a not native english speaker I was able to understand what they were explaining. Please do more episodes! I would be very interested in female ferility, including fibroids. I think it would also be great if the potcast/videos would be available in other languages. (I found the book in german and ordered it for my family). Great work. Please do more!!! Reply @nickmiddelton7852 @nickmiddelton7852 1 year ago @David Sinclair Thank you for sharing this incredible knowledge in your book, and this series. I very much hope you all make another season, and perhaps many more after that. Reply @katielkashan @katielkashan 1 month ago Dear Dr. Sinclair. Thank you for these very helpful presentations. I am 71 Years old and follow many of your recommendations. Just started to take NMN as well and I feel as motivated and active as I was in my youth. Reply @Tiernansteatime @Tiernansteatime 1 year ago Please have another season🔥 I look forward to the new episodes every week🙏🏻 Reply @Joehtoo @Joehtoo 1 year ago Love this series! Thanks David and team 10 Reply @wealbech @wealbech 5 months ago Yesterday I started reading an article on National Geographic about longevity and since that I’ve been thinking about the topic. So far, this channel is my best discovery in 2023. I’m happy to watch this videos and all this really mind-blowing information. Great content 👌🏽 I’m looking forward to seeing this incredible present and future ahead - I’m 24 ! Reply @OneWalkwithJesus @OneWalkwithJesus 1 year ago Hope you do a season two! Really learned a lot from these podcast. Reply @nteresi3708 @nteresi3708 1 year ago I would love to see a season 2. I think this podcast season has been great! Reply @anthonyribeiro882 @anthonyribeiro882 1 year ago I loved this podcast , looking foward for the season 2! You guys changed my life, seriously. I've kept a healthy diet for more thean 10 years , but fasting was I breaking through... i' d never felt so good and full of energy before...I'm 34 now Reply @mv-h5695 @mv-h5695 1 year ago Season 2 please!! Conversations about cholesterol, more about skin and hair, good and not so good-return for your money supplements. Great season!! Reply @loridouglas5576 @loridouglas5576 1 year ago Happy to keep listening. Looking forward to the next series already. I love the idea that humanity will become responsible for their own health although Big Pharma may not like that 3 Reply @stephenbethke4788 @stephenbethke4788 1 year ago A very informative series! I've changed my lifestyle as a result. I look forward to some of these interventions being available in South Africa at a price I can afford. Hope to see another series! Reply @gradysimpson3137 @gradysimpson3137 1 year ago Every single show is a 5 Star rating Please do a season 2 And yes longevity and sexual performance is a must topic!! 😃 Reply @heatherhilderbrand7298 @heatherhilderbrand7298 9 months ago I love you guys! Please keep all the information coming! It is fascinating. I have learned so much. Your format is great and the two of you are great together! Reply @roniesousa2953 @roniesousa2953 1 year ago 😱 OMG !! I have been learned so much with David Sinclair! English is my third language so I go back and forward with all those informations to understand better and pass on to my relatives ? Thank you so much both of you , I love to hear everything even the sponsor for the interviews lol 😂 You both are very funny too! 😂 thanks 😊 1 Reply @dahsk7872 @dahsk7872 1 year ago Please please please keep these going!! Thanks for everything 6 Reply @sophiefuller695 @sophiefuller695 1 year ago Fantastic series, full of food for thought. Interesting to listen here in the UK where funding for healthcare is so different. Yes please to series 2. More on eyes and ageing would be great, as would finding our way through the minefield of potentially dodgy supplements sellers e.g. for NMN… Thank you both!! Sophie (St Leonards on Sea, UK). Reply @AAA-of4vk @AAA-of4vk 1 year ago We need season 2. Thanks a lot for expanding knowledge about health. Reply @rosie1877 @rosie1877 1 year ago (edited) Thank you Dr. Sinclair, you make science so fascinating and thank you Matt, the two of you make these podcasts so interesting. 1 Reply @rhondaromano4531 @rhondaromano4531 1 year ago Please do another season! Thank you for sharing this exciting and much needed information! Reply @anderswallin3883 @anderswallin3883 1 year ago You should do a season 2! You should talk a bit more on how age reversing and fasting would affect common health issues like IBS and other digestive disorders and diabetes. Reply @andreac4319 @andreac4319 1 year ago Find your content fascinating and put in a way that is easy to understand. Not just the what, but the why and how of it. Thank you for the education 🙏🏼 . Will be sad when this series is up. 4 Reply @richardadams279 @richardadams279 1 year ago Please do a 2nd season. I would love a deeper dive in brain health. Also the timing of supplements. What works best when taken in the morning and evening. TY. Cheers. Reply @robintcm @robintcm 11 months ago I really appreciate the excellence of this material— please do another series! Thank you!! Reply @warrenmcpherson2083 @warrenmcpherson2083 1 year ago I'd love to see a season two, maybe with a few interviews with people like Aubrey de Grey, Elanor Skeekey, or other researchers. I'd also love perspective on some things that may not be the most promising but may be adjacent like moringa that is available to a large number of people and may or may not be helpful. Thank you very much. Reply @pedrolima6832 @pedrolima6832 7 months ago Loved the show. It kinda reminds me the StarTalk podcast, where serious topics are discussed in a chilled way. Season 2 needs to happen! Reply @lauramacaddino8481 @lauramacaddino8481 1 year ago Would love a season 2!! I am very interested in whether there is any information on how pregnancy/child-bearing affects longevity. Reply @phillipm5148 @phillipm5148 1 year ago PLEASE do a season 2! Can you go into more detail about Lifespan vs Healthspan? Some people disregard strategies (Metformin, Resveratrol, Calorie Restriction, etc) because they're "bad for Healthspan", which seems stupid. Reply @cherifaswearingen8105 @cherifaswearingen8105 1 year ago This was an amazingly informative series. Dr Sinclair I had read your book lifespan when it first came out, These episodes make it come alive. I have been following a plant diet and exercising for years. I would love to do the inside tracker testing, but it is so expensive. Is there a way they could lower their pricing? PLEASE CONTINUE THESE PODCASTS - THANK YOU FOR WHAT YOU DO. Reply @jameskennedy7989 @jameskennedy7989 1 year ago Count my vote for Season 2! I’ve read that babies born in Autumn are more likely to become centenarians. I’m curious about your opinions on this. Reply @lisanero5422 @lisanero5422 1 year ago Loved this informative series. Please make more. They give me hope for the future xx 4 Reply @10nut @10nut 1 year ago Great season, I'm looking forward for the next one! Thank you for your optimistic perspective. You are making a great team! 1 Reply @zootykins @zootykins 1 year ago Really love this season and it would be great to continue the series. Perhaps bring in guest speakers too! Reply @tarandhesi3450 @tarandhesi3450 1 year ago Excellent series....so informative.....please do a season 2, this is a hobby of mine 🙂. Currently, at the age of 41.5, my biological age is 16.5 years younger without supplements and I want to go further, so excited to try some of your suggestions. Thank you and keep up the good work👍 Reply @claudiafernandez3548 @claudiafernandez3548 1 year ago I never liked Wednesdays so much until Dr. Sinclair started his podcast. Thank you! 7 Reply @usmansarfraz3695 @usmansarfraz3695 1 year ago Love it ! Keep it up. +1 on the fertility as one of the topics to be included in the future podcasts in reference to the longevity and people having kids later in their careers. 1 Reply @zahrasebghatollahi @zahrasebghatollahi 2 months ago I enjoyed this episode a lot. Please try to provide season 2 of this series.... Thank you for your generous offering 😊 Reply @eirinistefanidou8161 @eirinistefanidou8161 1 year ago Do season 2, please!!! Really interesting and helpful. Thank you ! Reply @deevega6118 @deevega6118 1 year ago Love this series. There are so many great Educational podcasts. This one is one of the best. Reply @shawnaasendorf6908 @shawnaasendorf6908 1 year ago Thanks, I’ve learned so much. I have your book and will now dive into that and would love a season 2. Reply @skullface215 @skullface215 1 year ago I'd love to see an indepth episode on diet and what specific foods and recipes you use David! Thanks for your work 4 Reply @vijaythapa6566 @vijaythapa6566 1 year ago An incredible podcast series. Here's fervently hoping for many more seasons. 1 David Sinclair Reply @tatianaa677 @tatianaa677 1 year ago What a wonderful series!! Please do season 2 🙏. Reply @jesshatchette @jesshatchette 7 months ago Just finished binge watching, and I’m ready for season 2!! Reply @carolineduncan1637 @carolineduncan1637 1 year ago Yes I’d really love another season please. Covering fertility in older women in one if possible. Thanks for your great work in podcast. 1 Reply @NaiNai-cg6ht @NaiNai-cg6ht 1 year ago High quality content, thank you gentlemen. 10 Reply @victoriakelsey5913 @victoriakelsey5913 11 months ago Yes! to season 2. This series has been so helpful and interesting. Reply @healthiesthappiestwellbein3616 @healthiesthappiestwellbein3616 1 year ago (edited) Yes up for a season II ❤️ just got a great idea for my next content site - Internet of Body as I already have an IOT site 😉 I’m also a practicing yogi so understand the wholistic health of the body spans the meta physical realm which I’d like to explore and converge both truths! Support your continued work in all related fields 👏 Cheers Phil Reply @g42633 @g42633 1 year ago Please, please, please continue this fantastic content! (Listening from Hungary, btw!) 6 Reply @user-vf1il9uu7n @user-vf1il9uu7n 1 year ago I'm keen to hear season 2! As for suggestions, definitely, sexual energy is a good topic to cover. My other suggestion is a philosophical deep dive. I know you've said things like by living longer we can try second or third careers and try new hobbies, and I wholeheartedly agree. But I don't think you've covered the full implications of significantly postponing death. Many people have strong objections to the idea that go beyond the "too many people" observation. So I suggest finding a sincere, articulate opponent to extending life, someone who is going to challenge you, on philosophical/environmental/spiritual grounds, on the longevity interventions that you (and I) are so fond of. Reply @katenoel4346 @katenoel4346 1 year ago I would love a season two. I am curious about peptides. I would love a series that went through the various body systems or broke out the information based on different age groups and what you should be focusing on. I look forward to this upcoming technology! Thank you for all hard work putting this informative and enjoyable video series. Reply @maggiew7293 @maggiew7293 1 year ago Loved this series. Have been following you on other channels where I realized that I need and appreciate solid and verifiable information to assist me with my health challenges. This is the best resource ever. Heartfelt thanks and hoping you decide to produce a Series II. 5 Reply @jonparrott4081 @jonparrott4081 2 months ago (edited) You've been telling us quite well about what turns these aging pathway mechanisms "on." Also, what might be incredibly helpful, is publishing things that effectively turn them "off" so we can also avoid these chemicals or things that many of us might be experiencing readily... Reply @bgroisma @bgroisma 1 year ago Congratulations Dr. David Sinclair, Matthew LaPlante and team ! it was really wonderful, and like to add more content regarding microbioma, biofeedback with VO2max and stress measurements, cetons, etc. Reply @monikafollie9257 @monikafollie9257 1 year ago This is fantastic and informative. I devoured the episodes. Please do another season! Reply @christopherhernandez3498 @christopherhernandez3498 1 year ago Absolutely a season two! This information is transformative. Reply @buddingmillionaires9134 @buddingmillionaires9134 1 year ago Keep 'em coming! I love this information and staying informed helps me stay motivated. 3 Reply @lukejagodzinski @lukejagodzinski 1 year ago Please do the next season. Some things I would really like to hear about are: - How does your work look like? What are you guys doing on daily basis? What are you focusing on right now? You mentioned that you have a lot of startups dealing with multiple things. If possible, could you give more insight on each one? Would be even more awesome you did some guided tour around your lab. Maybe even do podcast in the lab and invite your teammates to talk in the podcast. - What about the human trails? Once you said that US army approached you and you're doing some trails for them? Can you reveal anything about it? - Could you talk more about those bio trackers? Just show some charts from them and maybe tell about discoveries you made over time by measuring your body? It's great to know that those trackers exist but just seeing some examples with data would be really nice. - You mentioned once that you use a lot of advanced technologies that wasn't available just a few years ago, like for example AI. Could you talk more about the usage of those technologies? Why you use them and how they speed up the process? Reply @adrianelsworth448 @adrianelsworth448 1 year ago Great series guys, series two is not a question but a must! Reply @markvoelker6620 @markvoelker6620 1 year ago Thank you for these podcasts, and for the work you are doing. You asked what I am interested in. Three things: 1) Practical developments that I can expect to apply to myself in the next few years (I am 66), 2) How to combine life extension and age reversal with bodybuilding (If that is possible), and 3) The issue of privacy and respect for the rights of the individual. The last subject is very worrisome for me. "Big Tech" has demonstrated a pronounced tendency toward authoritarianism, and I do not want to live in a world where access to these life enhancing technologies is dependent on me obeying government or corporate masters. The behavior of governments and large corporations during this pandemic, including censorship, medical mandates, and lockdowns, has shown that these organizations do not respect human rights, and indeed will use the powers inherent in big data and advanced medicine, to impose political tyranny. A world where access to rejuvenation technology is dependent on obeying political and corporate rulers, is a dystopia, not a utopia. Reply @tonyamckimmy693 @tonyamckimmy693 1 year ago Yes please, another series! Some ideas: Do emf's and things like cell phone radio frequency damage our cells to a point of concern or do they effect our longevity? More detailed information on women and menopause. How to optimize diet, exercise, and hormones during perimenopause and menopause. Treating Lyme Disease. Thank all of you for teaching us and at the same time making me chuckle! Love it! I love science and your podcasts help put hope back into my thoughts about our planets future which also restores my hope in mankind! Beautiful! 35 Reply 2 replies @jonparrott4081 @jonparrott4081 2 months ago I've been doing IF for about 7 years now. I started doing it myself instinctively and also because I had heard about yeast and mice living up to 30 or 40 percent longer. I was 55 at the time and was able to lose 75 pounds at one time and have done it a few times. The big thing I want to say here to these guys is that it only works for me when i gradually increase the fasting times in increments of 1 to 2 hours max each time. Beyond that and i get sick: a bad headache or even nausea. I got up to 42 hour fasts and came down easily to high school weight. But of course, as soon as i started eating again the weight came right back. But i still attempt to do this progression of slowly increasing my fasting times as i feel it is a form of exercise inwhich i build up my fasting muscles. It only works when i gradually put more weight on the bar so to speak ... it IS exercise at the cellular level. Which is what all these other things like plant supplements and cold & heat therapy are doing to us to activate these protective survival anti-aging pathways ... WE ARE BUILT TO EXERCISE EVEN AT THE CELLULAR LEVEL. Reply @savannah7375 @savannah7375 1 year ago I appreciate you guys making this podcast so much more than you can know. You have empowered me to heal myself and my loved ones. Thank you. In a future episode I hope you will cover female specific health. Looking forward to a second season (: Reply @gibbs21368 @gibbs21368 1 year ago Thank you for the show, I have learned so much from your podcast. Season two would be Great. Reply @SebastianTysler @SebastianTysler 1 year ago (edited) For the future episodes I think it would be interesting to hear about glycation and AGEs (advanced glycation end-products). Apparently high levels of AGEs are associated with premature aging and resveratrol can reduce negative effects of AGEs. 1 Reply @hectorlopezlaguna7633 @hectorlopezlaguna7633 1 year ago Love to have a season 2. Absolutely outstanding and brillian poadcast. I would be interested to know how to optimize human performance and recovery. A huge hug! 1 Reply @richardjosephnovak @richardjosephnovak 5 months ago (edited) Sinclair spending years promoting NMN and convincing millions of people to take it and those people reaping great health benefits and longevity is a wonderful thing. But then Sinclair taking part in the banning of NMN appears it could be a problem for his own longevity. I am not really sure if he can hide from this conundrum. 3 Reply @mariapapaturi8298 @mariapapaturi8298 1 day ago Can't wait for Season 2...3...4....! This has been amazing! Thank you! Reply @parkercallister4126 @parkercallister4126 1 year ago Yes, PLEASE do another series. The work you are covering, as you continue to emphasize, is moving very quickly and should continue to give you new material just on the general topic of anti-aging. As a woman, I would also appreciate more focus on issues for aging women (and younger ones as well!). Also, the several companies you mentioned that are working on various monitors, trackers, etc will certainly be on an accelerated development path and I would appreciate updates and news of breakthroughs. Thanks! Reply @lsjgill1 @lsjgill1 10 months ago Please do another season. It’s all just fascinating. Reply @ErrolGetner @ErrolGetner 1 year ago I looked forward to each of the 8 episodes. Totally in favor of a second season. 1 Reply @mariequiroz @mariequiroz 1 year ago This is such great content! 5 Reply @rogerbruce2896 @rogerbruce2896 10 months ago (edited) When will season 2 air? this is great stuff! Doing my best to make it for some of these advances. I am 60 and have some health issues so its been a struggle lately. Reply @yongli8616 @yongli8616 1 year ago This is a great episode! Looking forward to next episode about aging and society if possible! Reply @joeanarumo616 @joeanarumo616 1 year ago Thank you for doing this. My attention has widely shifted to better understanding longevity and what I can do to enjoy longevity. I very much hope you choose to make a season 2, as it would be nice to learn about the changes that are always happening. Reply @ernewmarket @ernewmarket 1 year ago Please keep the podcast going! Everything you talk about is so beneficial and interesting⭐️⭐️⭐️⭐️⭐️ Reply @haleis4117 @haleis4117 1 year ago I am currently on page 133 of Lifespan and suspect I will read it, or major segments of it, more than once and refer to it often after that and I thank you for it and the podcasts. Upon hearing my first of your then 6 podcasts at around 9 pm 22 days ago and feeling both satiated and guilty at the time after gorging more than a bit on ice cream (usual), tortilla chips (somewhat unusual) and donuts (almost never), I decided right then to begin Intermittent Fasting IFAN. I believe it was your 3rd episode that I watched and despite the fact that you recommended beginning slowly which I was prepared to do, I found that one meal a day with tea, coffee or a pickle if necessary between the one meal was actually very natural and easy. In fact, though it was all about longevity, to my surprise and pleasure, I actually lost 10 pounds in 7 days though of course much of that must have been water. I have now, after 22 days lost 13 pounds of presumably real weight and am now only 9 pounds from a BMI below 25, my newly determined target, and feeling that a real and permanent lifestyle set of decisions and commitments have been adopted. I am in your debt and deeply appreciative. For reference, I am 81 years old and two years ago I did a 220 mile walk across England over 14 days on a course that indicated my altitude climbs and descents was equivalent to climbing up and down the Empire State building 29 times over those 14 days and 220 miles. I mention this to indicate that I am in relatively good shape for my age with perhaps my inherited genetics and luck being the major reasons and it just seems so totally appropriate for me to compound that good fortune by doing as much as I can to improve my chance for a long and healthy life. I have also added and will continue to develop/refine an appropriate Intermittent Training regimen, mixing jogging and walking now and adding bicycling as the weather changes and am working on developing a healthy eating regimen as well. I did jump to page 304 to view your personal pattern but will probably complete my reading of Lifespan before developing my own and I of course have a desire to use several of the devices and services for personal monitoring of my biomarkers that you recommend in Lifespan and your videos but that too will possibly wwait for completion of my learning curve via both the book and podcasts. However, though I have used many words to discuss my own situation I really began my comment with an intention to discuss my wife, who is in the early stages of Cognitive Decline, most likely AD and in response for suggestions for ideas for a follow-on series of podcasts I would hope that you might include one on recommendations for currently effective steps we might take now. She has no Tau Tangles and is part of a phase 3 study with significant success in bring Amyloid levels to normal. Hopefully you might respond to this concern with information that allows one to one contact to discuss this further. Thank you again. Reply @ciarog6116 @ciarog6116 1 year ago Dr Sinclair, Your'e so sincere and seem so eager to help us by bringing all of these developments to us as soon as possible. Love your enthusiasm,and CAN'T WAIT!!! 3 Reply @lorene6245 @lorene6245 1 year ago I’m hooked. Would love a season 2, info on sexual performance especially with regards to post menopausal women, and any link between aging and the gut microbiome. 💚 Reply @leahsohn9457 @leahsohn9457 3 weeks ago It's been one year since I discovered David Sinclair, and how come only 300k people have watched the whole series... this lifespan education should be put in primary school, and I'm going to make a Chinese short version for my parents. So difficult to change their mindset and the way they eat. Thanks so much, Professor Sinclair and Mathew, and the team! Reply 1 reply @saraarjomand5584 @saraarjomand5584 1 year ago Thank you guys for an education about aging. Read your book Lifespan and have been a fan ever since. Love if you can do another 8 episodes!!! 1 Reply @JulieKendall-yo6vq @JulieKendall-yo6vq 8 months ago Please do another season. I've loved all the information, so anything you decide to do in the future works for me. Reply @AdamVsAccount @AdamVsAccount 1 year ago Seems like there's a lot of debate about resveratrol & sirtuin activation as well as the effects of metformin on longevity of non-diabetics. Would be great to have a quick episode detailing and refuting the arguments against those 2 things 14 Reply 2 replies @SemiPolymath @SemiPolymath 1 year ago Special request for future podcast seasons: each year, create a "Developments since [year of last season]. This would be the most exciting segment, and be the reason I rewatch each podcast from the previous year. More immediately, thank you so much for filtering, collecting, and interpreting this fascinating and vital research for us! 1 Reply @saraberger3967 @saraberger3967 1 year ago Thank you so much for sharing your knowledge ❤️ Please make more seasons! 😘 Reply @omarvalle69 @omarvalle69 1 year ago Fantastic material!! Please do another season! There is so much misinformation out there you podcast is like a light in a dark scary tunnel :) Reply @linaaboudheir3878 @linaaboudheir3878 1 year ago Honestly Dr David & Matt an amaaazing episode , lots of knowledge and research in the pipeline , I need to listen to it more & more 🥰yessss please more episodes Cannot have enough Best of luck in outcome of research Sooo lucky to be living I. This era & witness ( & try too ) what’s happening Reply @0031400 @0031400 1 year ago (edited) Love this podcast. Please do a second season with an episode focused on stem cell treatments for orthopedic injuries. How does 'homing' work? What diet should be followed before and after treatment? The difference between stem cell treatments offered in the US vs. abroad. All things stem cells! Reply @weronikakrynicka4037 @weronikakrynicka4037 1 year ago (edited) Might be uncommon, I'd love a podcast on Epstein Barr Virus - how it relates to longevity, whether there are any sights for complete removal of it, whether those 5-10% who are uninfected live longer, is it even possible that apart from immunodepleting it could have some hormetic effect, etc.;) Thank you a lot! 3 Reply @rickp5685 @rickp5685 1 year ago Season two...Season two...Season two!!! Great job, gentlemen! Very informative and for those of us that understand the importance of taking our health into our own hands this is invaluable. Reply @audreystauffer3016 @audreystauffer3016 7 months ago Thank you for your podcast, i love it and i am learning so much. It is really fascinating. I would love you to cover topics such as fertility as well as women and aging. Thanks again 🎉 Reply @doubleunderfire7964 @doubleunderfire7964 1 year ago Great series! I would like to suggest another season with some time dedicated to the financial markets' outlook on longevity research. For instance, I think it would be fascinating to hear if there are ETFs or mutual funds that have a mandate to track emerging technologies related to longevity. Reply @shirleylum2198 @shirleylum2198 1 year ago You get 5 stars! There's so much and I would like to hear more and yes, Season Two would be awesome. Reply @larry8746 @larry8746 1 year ago Great information guys. Please do a season two. Already looking forward to it. Reply @tristanteotcteo @tristanteotcteo 1 year ago Hi. Appreciate your work. Would like to hear your response to the recent resveratrol controversy that has been circulating. 17 Reply 3 replies @saraspano @saraspano 1 year ago LOVE this podcast!!! We need Season 2! Reply @blason71 @blason71 1 year ago I've just finished this amazing series. Thank you so much for all the great information. Please do a season 2 and 3 and 4, etc. 😂 1 Reply @florenciamartinez8025 @florenciamartinez8025 1 year ago I'd love to see more seasons. Great podcast!!! Reply @pamelaferrada579 @pamelaferrada579 1 year ago Yes please!!! A session two would be incredible Reply @mayrakennedy6200 @mayrakennedy6200 1 year ago I can't get enough of all the information on your channel. I actually just got my Levels CGM. Now I've been using it for 1 week. I'm trying to learn all the spikes and meaning to improve my health. LOTS to learn. Episode suggestion :-) what to make of spikes when eating healthy foods, what is good and what is bad. I'm not diabetic. I'm an athlete and trainer so my glucose is not average. Thank you!! 1 Reply @luhark9 @luhark9 1 year ago Listen carefully - many good points and Lifespan was worth a read as well but this could also be considered one giant infomercial/commercial. Continues to mention the sponsors and other companies even outside the sponsor/advertising segment. 3 Reply @drewalexanderwest8501 @drewalexanderwest8501 8 months ago Do another season!! Thank you for changing my life perspective and hopefully my health. Reply @robertcarpenter1296 @robertcarpenter1296 1 year ago Yes please for season 2. Best podcast ever! Thanks. Reply @kelvinle6118 @kelvinle6118 1 year ago (edited) Many of the essential job are shift workers: nurses, police officer, etc. Having an irregular sleeping and eating time yet physically demanding work makes good practices such as sleep 8 hours per day or skip breakfast impractical. It would be great to hear your discussions on how shift workers can better take care of their health. Reply @ljacobs5478 @ljacobs5478 1 year ago (edited) Just found you through the Huberman podcast. Great series, I took so many notes. Would love more in depth info on supplements, which companies to trust, what to look for etc. also more info testosterone building for men and improving quality of life for women going through menopause. Also more clarity on cortisol and it’s relation with exercise(good and bad) and stress etc. thanks 😊 Reply @joecicitta7488 @joecicitta7488 1 year ago Great podcast, definitely would like a season 2. Reply @lollyb8808 @lollyb8808 7 months ago I can't believe you lobbied against nmn as a supplement. As someone who has an autoimmune condition has exhausted every avenue, including pharmaceuticals, nmn is the only product that has made me feel like my previous self before the onset of my illness. It's disgusting and appalling that someone who preaches and promotes wellness is the one who bought on its demise. No bs on regulations because you fair well know once a prescription there will be limitations on who it's prescribed to. As someone with a rare autoimmune condition, I'm far too familiar with being able to access life-saving medications because my condition is rare and not listed as a requirement for a medication on the pbs. As a so-called humanitarian, you should be ashamed of yourself. 5 Reply @barbarar8609 @barbarar8609 1 year ago I have enjoyed your series and encourage more. An occasional update on information already discussed is a good closer to end next series. Thank you for working on reducing costs for available tools to keep us healthy and possibly reverse or repair damage. This is by far an issue for limited income or retirees who have the time to listen and follow. Information is overwhelming so any time you can break it down is appreciated. Reply @amorsi72 @amorsi72 11 months ago I love and value all the information you have to offer. I have been following you for 5 years. Please continue with this valuable information. Reply @stevef6523 @stevef6523 1 year ago Definately a season two, it's been super interesting Reply @itsstefanie6112 @itsstefanie6112 6 days ago Yes please do a season two. I've learnd so much and you two are awesome Reply @SlightysBack @SlightysBack 1 year ago (edited) I always wondered during the podcast. Why is temporary blood sugar rise bad per se? I.e., what is the mechanism how blood glucose spikes affect aging? Would love to hear a deep dive on that in season two:) Reply @mysteriouse5891 @mysteriouse5891 9 months ago I've just started taking NMN have started to see good results. However, the FDA has supposedly banned NMN for non-pharmaceutical use and a company you are apart of appears a part of it. Any comment? 3 Reply @christophergray9227 @christophergray9227 1 year ago I would love to see a season 2. One thing that I would love to see is how longevity techniques impact allergic reactions. I noticed this past year that after I lost 50 pounds (mainly thru fasting) that I was not as impacted by airborne allergies. Would allergic responses be potentially alleviated thru these longevity resets? For instance, I have suffered from Oral Allergy Syndrome my entire life and it seems to be getting worse as I age. Would resetting my age help alleviate my OAS? Reply @victornoguera9012 @victornoguera9012 4 months ago Many of the tests and monitoring systems you talk about (Inside Tracker, Levels... ) are US based. Some info and advice for people outside US would be great. Also, info and advice on how to obtain supplements from trustworthy sources would be appreciated. A second session podcast would be great. Thoroughly enjoyed this one. Thanks so much for all the effort, time and information shared. Greatly appreciated 1 Reply @sixx9639 @sixx9639 1 year ago Love what you do? That's an understatement. I followed every word you both said. Thank you for this season! Season two...yes please! Reply @ABagala1 @ABagala1 1 year ago I turned 50 in November and I notice I’ve been listening to David Sinclair more and more. The advice is invaluable and inspirational. Reply @MarieDawnLamPropertySG @MarieDawnLamPropertySG 1 year ago Thank you so much Dr Sinclair and Matt! I’ve been listening to all 8 episodes and am so inspired and motivated to continue doing what I’ve started doing after I’ve witnessed how my dad spiralled downwards in health in his 80s. I’ve started to eat right, learnt to intermittent fast and have been exercising daily, reducing not only weight but fat % and am looking much younger than I was even though I’m already 50! So I’d love to hear out your next 8 podcasts! Reply @kevinjolin6313 @kevinjolin6313 8 months ago (edited) Mr Sinclair, why have you submitted paperwork to the FDA telling them to regulate NMN? Some think that you could possibly be trying to own NMN from behind the Scene. Maybe trying to make it a pharmaceutical product? Impose control over the supplement? 3 Reply @christiedessy6801 @christiedessy6801 1 year ago Dr. Sinclair and Matt - We are hungry for more - I have been interested in the "fountain of youth" since I was a teenager - and now into my 70's. Keep asking the right questions ! Yes to season two. Reply @cindyspitzer1572 @cindyspitzer1572 9 months ago Please focus on digestion, aging, and GI diseases of aging. Would also like to hear more about auto immune diseases, if possible. Loved, loved, loved season one. More please! Reply @Edaryion @Edaryion 1 year ago Not only do I learn from these videos but I also enjoy watching them. You two are kind & pleasant people! Reply @grahamknights7356 @grahamknights7356 9 months ago This series has been perhaps, one of the most interesting podcasts I've ever listened to. It is clear that aging happens, but the idea that it can be lived healthily is very exciting as we don't want to be a burden on our children or the economy. If half the money spent on age-related treatment now was spent on prevention, i.e. developing health tracking devices, diet education, early detection, etc. then we wouldn't have to spend the eye-watering $amounts on age-related diseases that we do now. Everyone would be better for it. This has been a fantastic podcast. I'd love to hear more about health tracking devices and techniques and how we could change our health system from literally the ambulance at the bottom of the cliff to the fence at the top. Thank you. Reply @robertfleischer6068 @robertfleischer6068 1 year ago I have taken NADH FOR 35 yrs. I am 80 yrs old and have MS and I play pickle ball 5 days a week for two hrs. I am screaming yes yes yes to what’s going on now! Thank you Dr. Sinclair Reply @ravenfire77 @ravenfire77 9 months ago When are you going to make a statement about the FDA banning NMN and your involvement? 5 Reply @marccharach651 @marccharach651 1 year ago This has been amazing and I am so grateful to David, Matthew and the team for spending so much time to explain all the science in a way that even though it gets quite technical at times, it is still enjoyable to watch and fascinating to hear. You have already contributed immensely to my current lifestyle change by recommending fasting and more exercise and I am already feeling great. Please make season 2, I can't wait. Thank you so much! Reply @gizmoloft9776 @gizmoloft9776 1 year ago Will love another series, really enjoyed this one. If there is an online course to learn more about anti-aging (hint hint), I will happily subscribe! Reply @mikemcclair @mikemcclair 1 year ago Yes to a season 2! We definitely want more!!! And by the way, thank you so much for doing this. This is literally life altering work and I would love to keep learning more!!! Reply @manologv1852 @manologv1852 1 year ago Pity that there are no more videos like these. They are a jewel for the Internet. Reply @karenfarley8155 @karenfarley8155 1 year ago I have LOVED listening to you guys! I seriously have been looking forward to Wednesdays for the past eight weeks. Please do another series! And come to Utah for sure! Maybe I can meet you guys in person. Ha ha. I am a 44 year old woman and would love to learn about health care concerning menopause and specifically how to regulate hormone levels during that time. I would also love to learn some things about increasing my sex drive and my ultimate enjoyment of sex! Thanks so much for all you guys do! I look forward to hearing more from you. Reply @StateofBeingness @StateofBeingness 7 months ago David Sinclair, I will be respectful, but I will also say that your efforts through metro biotech to have NMN supplements taken off the market so that your company can capture all of the demand is selfish and greedy, and to the detriment of the larger population that will no longer have access to this supplement unless they have a doctors prescription and then will have to pay a much higher price. You’re not working in the best interest of society for the purpose of mankind. You are working for the purpose of making yourself rich. 8 Reply @adrianaheinzen6914 @adrianaheinzen6914 1 year ago Thoroughly enjoyed this podcast! Would love to see more seasons! Thanks for sharing your knowledge and expertise in the field 😄👏🏼 Reply @dorotago9588 @dorotago9588 1 year ago I enjoy and appreciate your podcast very much. Thank you for doing this pro bono. This way I can summarize takeaways to my parents who don’t know English, but should be informed about longevity lifestyle. And this is a pity that most of scientific news are in English and older people from non-English speaking countries cannot learn by themselves. Hopefully your book will be translated to many languages. Reg content of your podcasts, It is much to digest for a person without scientific background, so notes are really helpful. In season 2 You could talk more about best bio-available supplements and ingredients to watch out for. So many of them on the market… thanks! Reply @suzanbakalovarealestate2533 @suzanbakalovarealestate2533 1 year ago Please do more episodes!You are so inspiring! @davidsinclair and @MatthewLaPlante Reply @kickitillman7730 @kickitillman7730 1 year ago All the way from Sweden, thank u so much for a wonderful podcast. Lifechanging 🙏 I´m about to finish th book aswell and I´m looking forward to a season 2. Reply @wendylou803 @wendylou803 1 year ago Please, please continue with season two. We are learning a lot from you. Thank you so much for sharing the knowledge. We appreciate it a lot! Reply @charlesryan8476 @charlesryan8476 1 year ago Why did you block Dr. Stanfield? 3 Reply @sheilareynolds5487 @sheilareynolds5487 10 months ago Love it! I took a ton of notes. Please do another season. Thank you for this information. I took it in like a sponge!!! 👍🤗😘 Reply @elbrooks @elbrooks 1 year ago Fantastic podcast! Please do season 2! Reply @vladyslavcherevkov9282 @vladyslavcherevkov9282 1 year ago Thank you so much for the amazing work!! Season 2 please with AMAs Would like to know about how most brands of NMN don’t actually have NMN when you test it because the molecule breaks down after 45 days. Would like to hear some reputable NMN brands as well as crystallized NMN Reply @JH-pv6rd @JH-pv6rd 8 months ago Thank you so much for sharing your knowledge with us. I'm looking forward to watching season 2. Reply @lauriemeunier5328 @lauriemeunier5328 1 year ago Yes David more please! Thank you, Matt and your entire team. Reply @valerieramos1630 @valerieramos1630 1 year ago I am Obsessed with All these videos… I’m learning sooo much and it makes me so Hopeful on a Longer healthier life for our Kind. Thank you so much for sharing. And YES for a season 2. Maybe more on Menopause and healthier aging for women and fertility. I went through that and I’m sure that would help so many women in their child baring age. Reply @AhmedBodhi @AhmedBodhi 1 year ago As many seasons as it takes to get to that future! Love your commentary and balanced views. Reply @fermentadosthegreenestme @fermentadosthegreenestme 1 year ago These videos have been extremelly educative. Please season 2 yessss, Aging and gut health please Reply @maximepirson2831 @maximepirson2831 1 year ago pls do a season two ! the topics are so interesting ! Reply @mindeconnelly3050 @mindeconnelly3050 1 year ago Thank you Dr Sinclair. I’ve been following you since I read your book. I appreciate the deep dive into the science! Reply @nikoleinonen2368 @nikoleinonen2368 7 months ago Yeah, please more seasons. I just found this a month ago, mind-blowing stuff!!! 1 Reply @MichelleEinsteinSongBirdsong @MichelleEinsteinSongBirdsong 5 months ago Really enjoyed this series. I hope you will do another. I would like very much to hear about fertility in womb-in (women). I started a subscription to AG1. I hope one day to be able to afford inside tracker. I am a lactic vegetarian and a teetotaler since 1970. I am 78 years of age. Thank you for this valuable information. Reply @lindawalker2092 @lindawalker2092 1 year ago Yes!…for a Season 2! Am at age 72, in good health, no prescription drugs, weight appropriate, and active. Healthy brain is my primary health concern as I see friends, my age and older, suffering from debilitating memory loss. Also, I would enjoy looking better. My order of NMN and Resveratrol just arrived yesterday. And so it begins. An episode I’d love to see would be about what those in their 70s and 80s could benefit the most from, assuming overall good health to begin with, in the way of supplements, maybe prescriptions, and best monitoring info for going forward. Also, it was challenging to chose the NMN and Rservatrol products. As a layperson, knowing what to look for and which ones to purchase is a big learning curve. Some additional help in this area would be appreciated? Am not afraid of dying. Just want to have a good quality of life while I’m here as well as not being a burden to my children and grands. Being productive and supportive for my family and community is the very best I can strive for. Thank you so much Dr. Sinclair and Matt for this series of 8 remarkable videos. I applaud you both and so appreciate the wonderful up-to-date research and results. Kudos!!! 2 Reply @tyharmon8702 @tyharmon8702 1 year ago This information is so important for the general population and legislators to know and prepare for. Please keep educating the public!! SEASON TWO HERE WE COME 1 Reply @alexkimani2519 @alexkimani2519 1 year ago Am watching from Africa and this makes the future so hopeful. This research linking aging and disease is an eye opener. Please we are waiting for season 2 Reply @arneingvaldsen3982 @arneingvaldsen3982 1 year ago Great podcast. Look forward to season 2 👌 Reply @JimmyBasquezatx @JimmyBasquezatx 1 year ago Awesome podcast and book. Please do a season 2. Reply @gramma175 @gramma175 1 year ago Thank you both and the Team, I’ve been lowering my insulin before this Well done Informative Podcast. I’ve learned so much more and would LOVE for of these Podcasts. Thanks so very much! This is life changing for me! Let’s see a second Podcasts! 😱💕💕 Reply @mohammed_sa5091 @mohammed_sa5091 1 year ago I hope see the season two very soon, and we need talk about fertility, sexual performance, and other scientific topics. a lot of thanks in advance. Reply @lme3683 @lme3683 1 year ago Yes, please please please keep doing this podcast. Forever?? 😉 SO fascinating. Thank you for your work. Reply @stuartwatterson1375 @stuartwatterson1375 1 year ago Please do season 2, loved this! Reply @CaptainGoosetronaut @CaptainGoosetronaut 1 year ago Pleaaaaase please do a season 2. I miss this podcast so much! Reply @gabrielaradu2970 @gabrielaradu2970 1 year ago I would like a season two, not only for what we can learn, but also to see how you interact with your lovely colleague. Thank you! Reply @barbaralanzante5619 @barbaralanzante5619 1 year ago Oh YES Please do season 2!!! I agree with little house in big city!! Definitely a lot of information to wrap your mind around it would be great if you keep doing what you’re doing!! I have written on different platforms of your social media in reference to doing an episode on “BIO IDENTICAL HORMONAL THERAPY “(menopause) going through menopause for women “hormonal therapy is bio identical hormones safe for the body ? or do you suggest that you should just do the things that you’re speaking of? Intermittent fasting Using foods properly Exercise Sleep Monitoring devices Thank You!!!!! B Reply @laureningham1391 @laureningham1391 1 year ago What an amazing and informative series. Please do another 🙏. Reply @imagin8orr @imagin8orr 1 year ago Hey guys, loved the series - please do more! Reply @victor9027LIBERAL @victor9027LIBERAL 7 months ago Me leí lifespan, estoy viendo todos los capítulos de este canal y me encanta, los datos, las experiencias y la forma en la que desarrollan el contenido, el sentido del humor en fin, un trabajo digno de ver. Creo que sí en un futuro tengo un hijo lo voy a llamar David jaja, les voy a enseñar sobre el peligro del azúcar y tratar de estresar sus cuerpos para que permanezcan lo más sanos y fuertes posibles. Sigan así quisiera que saquen capítulos eternamente pero eso es biologicamente imposible o no ?). Jaja saludos desde Argentina! Reply @lizzyschenk8878 @lizzyschenk8878 1 year ago The technology is fascinating! Having a private company own this data doesn’t make me feel any better than the government owning it. (particularly insurance companies) Absolutely agree serious conversations need to happen now about what safe guards can be implemented to protect people. On the flip side can you see the reaction of some of these Q folks when they are asked to wear something that tracks their biometric data? On a side note PLEASE keep this podcast going! Reply @DebiDalio @DebiDalio 11 months ago I will be turning 64 (Earth years) this year and everything you are talking about is of vital interest to me, so please keep us all informed. Reply @mousecatcher1 @mousecatcher1 1 year ago I enjoyed the series thus far. Two topics I would like to see addressed: (1) increasing longevity in pets, especially dogs (2) philosophical implications of longevity. Is this another "immortality project" in our search to create meaning? Reply @alexanderthomas3457 @alexanderthomas3457 1 year ago (edited) WOW, I have learned so much, which makes me hungry for more. I first saw you with Andrew Huberman then found your YouTube / Podcasts! Totally blown away with what I have learned! I am already applying many changes to my lifestyle based on information you provided. I have also turned on several others to your presentations. I am going to explore Athletic Greens, Inside Tracker and Levels to get more information to use with my doctor and cardiologist. This is information that everyone needs to hear. YES DEFINITELY DO ANOTHER SERIES!!! Please!! Reply @baconinvader @baconinvader 1 year ago Love this podcast! Would love an episode on the relationship between aging and sleep Reply @charlottevane1951 @charlottevane1951 1 year ago Pleaeeeeese do a season 3. These series are helping me get healthy. TY so much Reply @thanhnuct @thanhnuct 4 weeks ago Please do the season 2, A fan from Vietnam ! Wish you guys have wonderful health then can help the publics more ! Reply @Rob-zz4qj @Rob-zz4qj 1 year ago I've enjoyed season one, although I feel like sometimes it can be hard to take away practical advice that can really be put into use. A lot is very in-depth scientific discussion which i enjoy, but come away thinking there's not much new I can actually implement Reply @XhubiuXRock @XhubiuXRock 1 year ago Please do make more episodes!! I also hope that those technologies finally come to Europe!! =) Reply @Marylin2011able @Marylin2011able 1 year ago Thank you so much for your amazing job… I love this podcast !! God bless you!! Reply @snelson7679 @snelson7679 1 year ago (edited) Loved all 8 Podcasts and learned a lot. Thank you for all you do for everyone! I live in Canada, so ordered the NMN & Resveratrol powders from Alive by Science. In Canada we can't get NMN and can get a very grey looking Resveratrol in capsules only ... plus doctors here won't give Metformin unless you have diabetes. Doubt if Inside Tracker can come to my home to do blood work - ha ha. As I have RA, I get a LOT of blood work done every 3 mos here in Victoria, BC. Is there a SPECIFIC blood test that I should ask my doctor for? Reply @isabelleinnocenti2194 @isabelleinnocenti2194 1 year ago I'd love another season! I'd like to know more about how to reverse grey hair color back to its original color, I'd like to know more about ideal lifestyle factors for women who are breastfeeding, and more info on how to delay or reverse menopause, and how to optimize DHEA levels. Many thanks! Reply @getaresios303 @getaresios303 1 year ago Would absolutely love a season 2. Yes yes yes Reply @donrounds7791 @donrounds7791 1 year ago I love this one for all the tech. This is such an exciting and innovative area and I cannot wait to get my hands on the near-future gadgets and services to enjoy a healthier and longer life! Reply @collettecohen-henriques3823 @collettecohen-henriques3823 1 year ago Really enjoyed this podcast. Looking forward to Season 2. Reply @mariavalentinazamorablanco7987 @mariavalentinazamorablanco7987 1 year ago Hello ! I´ve really enjoyed the episodes. I have gained a lot of understanding on this issue about extending lifespan by practising a healthy lifestyle. I am trying to find my own protocle and would like to achieve results in the short term beacuse, as you said, my family deserves it and also me, of course. I have a comment on the illnesses that appear at a young age, children suffering from cancer and other deseases. If they are so young and should have all those levels of youth DNA at the top, why do they get sick? Could you explain this? Reply @rickemmet1104 @rickemmet1104 1 year ago Okay, here's my two cents worth: this is super interesting stuff - for obvious reasons. This is such important material, that I've sent links to dozens of people. Each episode is about an hour, but these take at least four (or more) hours because there's such a plethora of scientific studies, and heck, just the terms to go look up. It's easy to spend most of a day, not looking at the videos, but just going through the literature associated with these specific topics you guys have covered in each episode. And just an observation: Matthew, in this last episode, looks like a bookie - and one that doesn't even need an enforcer - LOL. This has been very informative and both of you guys come across very well, it has been fun to watch all of these. Please do another series! Reply @lyricalloophouse2497 @lyricalloophouse2497 1 year ago Im wondering if the reversal of blindness in the mice would also work for other diseases that cause blindness such as diabetic retinopathy? Thank you for everything @David Sinclair ! 1 Reply @blackjaguar9861 @blackjaguar9861 6 months ago Thanks a million for this outstanding podcast series! Which brand & model monitors would you suggest for the 5-6 biomarkers you mention at 20:31? Thank you Reply @franzlarsen7622 @franzlarsen7622 1 year ago Fantastic series of very educative podcasts. Please do us the favour of an other series 👌 Reply @woodypognon3961 @woodypognon3961 7 months ago Hi Dr Sinclair Happy New Year! Love your podcasts. I would love to hear you talk about drinking water daily and heard you touch on it on one of you podcast the effects of red light and inferred lights have on the bodies longevity. Thank you for you knowledge and the work you do! Reply @dafu5704 @dafu5704 1 year ago Great stuff. Looking forward to season two. Thanks. Reply @mariellebraz @mariellebraz 1 year ago Please continue with the podcast I would love to a season 2 on fertility and aging. Dr Sinclair you look remarkably youthful 😃 Reply @RisqueBusinessNews @RisqueBusinessNews 7 months ago Absolutely fantastic content - keep it up! Reply @eleanormclaughlin7509 @eleanormclaughlin7509 1 year ago Awesome series. Please do a season 2. Reply @cheshirecat5571 @cheshirecat5571 1 year ago Yes, a second season would be wonderful. Please do continue. With the research, drugs and technologies increasing exponentially, having an expert like Dr. Sinclair keeping us informed on the latest findings would be great. I would be curious what Dr. Sinclair's take on the Wim Hof Method might be. If you continue into another season, please consider this topic. Reply @sandratislo9135 @sandratislo9135 1 year ago absolutely mind blowing, looking forward to listening season 2 2 Reply @RoseMary-gl4ee @RoseMary-gl4ee 1 year ago (edited) Thank you for the wonderful season, love you both! How about some cutting edge knowledge on cure for herpes simplex 2? Thanks again for everything! Season 2 yessss pleeeeeease! Reply @cesaremarchetti685 @cesaremarchetti685 1 year ago (edited) Please do season 2. Topics: Myopia/Hyperopia & Age reversal. This could potentially help millions if not billions of people worldwide... Reply @Stylishh7 @Stylishh7 10 days ago (edited) Yes on season 2, I love the idea of having health enough for a second career in life. Being perceived by an employer as not too old to hire, since many job applications are done over the internet and no face to face meeting until the final picks and those are mostly zoom meetings. Health and vitality are not recognized. Other issues as well many people not having kids to take care of them as they age and fall sick. Either due to family moving for jobs or being childless. Being healthy enough to be independent. Another topic to talk about as well is dating from 40 on, many changes from infertility, age gap, ability, health status. What reversing the clock can do for these issues. Thank you for doing this podcast. Reply @bornbarnett @bornbarnett 1 year ago Absolutely inspiring, more please. 1 Reply @photonatom1740 @photonatom1740 1 year ago 5 stars! Yes, please do another season to go deeper on supplements, measurements and Dr Sinclair's new book (?). Thanks!! Reply @amyoffret1 @amyoffret1 1 year ago Would love a season 2 on women’s fertility and hormones!! Also information on how a ketogenic diet and fasting effects women’s hormones. Reply @constancechan7748 @constancechan7748 1 year ago I am really looking forward to a season 2 pretty soon!! thank you both ! Reply @jasonc5289 @jasonc5289 1 year ago (edited) Dr. Sinclair, I applaud you. Unfortunately, what you're doing the medical establishment doesn't want out. My neurologist, one of the "best in America", doesn't want to see me because I defy everything he's been taught to believe. My doctor is no better but he's serviceable. Keep providing your message and hopefully our medical community, which we rank 37th in the world, think about that where you can go for BETTER health care, anyways, will wake up. I applaud you again. Bravo. Reply @maximov23 @maximov23 1 year ago Amazing podcast! I will be waiting for the second season Reply @gonzalomontes5091 @gonzalomontes5091 3 months ago Your level of impact is remarkable. Hope you can continue promoting health education and get people´s mindset to a higher level so that they will start asking for more from the governments... there is an evident lack of focus at a global level. Reply @sebbyabbate9581 @sebbyabbate9581 1 year ago Please! Another season. This was very informative. Reply @chrisr7426 @chrisr7426 1 year ago Such an amazing and enjoyable podcast. Sign me up for Season 2!! Reply @contretemps6565 @contretemps6565 1 year ago Guys this is treasure! We definitely want the series to continue. Topic suggestion, though may be covered many times before, we still want to hear it from you, how stress affects our body, brain, hormones, immune and cardiovascular system, mental health and everything.. how can we trace the destructive effects of it in our systems and reverse it? Thank you a lot for all this valuable information. 2 Reply @miketabiri4831 @miketabiri4831 1 year ago Dear David you are the greatest scientist In the world, in Physics we have Einstein and in Biology it is you. I owe you a lot for the knowledge that you have given me. Please keep on giving us as much information as you can. I can listen to you for ever. Please let us know if Ca AKG is safe Best regards Mike Reply @CrisCita1801 @CrisCita1801 1 year ago I love all this podcasts and lately I've been thinking a lot about male×female differences in strategies for health span. Reply @sunshinesunshine6130 @sunshinesunshine6130 1 year ago Please do another series. You are both wonderful. Would love to hear about the lymphatic system. Is it true that tattoo ink fills lymph nodes etc. Reply @angiedamian681 @angiedamian681 1 year ago Yes, thank you Dr. Sinclair, pls do more episodes and God bless you both. Reply @catherinebe5384 @catherinebe5384 1 year ago I hope you do a second season it was absolutely fantastic. My suggestion would be very specific per decade. For example I am 63 years ol