The Peter Attia Drive Podcast guest, Dr. Matt Kaeberlein "Anti-Aging" Drugs — NAD, metformin, & rapamycin plus Thomas Seyfried on cancer reteaches

| The Peter Attia Drive Podcast (Ep 207, AMA 35) Peter Attia MD 399K subscribers 54,752 views May 16, 2022 The Peter Attia Drive Podcast In this “Ask Me Anything” (AMA) episode, Peter is joined by special guest, Dr. Matt Kaeberlein. Together they answer many questions around the field of aging with an emphasis on three specific molecules— NAD, metformin, and rapamycin— and their purported geroprotective qualities. They first discuss aging biomarkers and epigenetic clocks before breaking down the advantages and limitations of the most common experimental models being used today to study aging and pharmacological possibilities for extending lifespan. Next they dive deep into NAD and the much-hyped NAD precursors, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). They compare data from NAD precursors to studies on metformin and rapamycin, assessing how they stack up against each other and using the comparison as an opportunity to illustrate how to make sense of new experimental data and make smart decisions about how to approach future research. In this sneak peek, we discuss: 00:00 - Logic behind comparing NAD precursors to rapamycin and metformin; 03:49 - Aging biomarkers: current state, usefulness, and future promise; 12:37 - Epigenetic clocks: definition, use case, and limitations; In the full episode, we also discuss: - Advantages and limitations of studying aging in non-humans and the strengths and weaknesses of different model systems; - Aging studies: importance of control lifespans and the problems with reproducibility; - Intro to NAD, potential role in aging, relationship to sirtuins, and more; - NAD precursors (NR and NMN): current data; - Human studies with NAD precursors; - Comparing NAD lifespan data to data from metformin and rapamycin; - Defining a “clean drug” and a “dirty drug”; - Reason for the lack of rapamycin studies in humans compared to NAD and metformin; - Ranking the geroprotective molecules in terms of risk and reward; and - More. -------- About: The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 40 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life). Learn more: https://bit.ly/3Mg5zGz Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle Chapters View all Explore the podcast 241 episodes The Peter Attia Drive Podcast Peter Attia MD Podcasts Peter Attia MD 399K subscribers Videos About 111 Comments rongmaw lin Add a comment... @albertvasquez3564 @albertvasquez3564 1 year ago I was under the impression that this podcast was going to provide more in-depth information as to how drugs like metformin, NAT and Rapa myosin benefits for slowing down aging/reversing 18/increasing life and health spam. Instead this podcast was more about stating the obvious and everything that we already know which is finding valuable bio markers to determine whether these medication/supplements are actually benefiting any of those objectives. This was more of a podcast of two really smart guys stating the obvious in which that it’s really hard to determine any of these objectives on basic pre-existing biomarkers. 50 Reply 6 replies @rapamycinnews @rapamycinnews 1 year ago Great to see a science-based review of NAD precursors and comparison to drugs like Rapamycin and Metformin. And, the ranking of Rapamycin well above the others is good to see. 1 Reply 5 replies @KatJ3st @KatJ3st 1 year ago You have to include an intensive MRI brain scan in the 'rate of aging' and predisposition to death. 6 Reply 1 reply @dlbdlb3919 @dlbdlb3919 3 months ago Peter clearly a lab technician into drugs not a into "how can we find a solution" type of guy Reply @susannemcallister @susannemcallister 1 year ago Excellent discussion. David Sinclair has done the epigenetic tests on mice with fascinating results. 3 Reply 1 reply @MarielleCasper-fm5ks @MarielleCasper-fm5ks 4 months ago Another fantastic episode! What was the 3rd product in the stack for fertility/libido? Maca, Tongkat, and ? It sounded like “Systanche” but can’t find that anywhere. Thanks! Reply @hollyhawks8899 @hollyhawks8899 1 year ago (edited) The larger podcast on this was more helpful than this podcast...I am a 60 year old female on metformin at three times a week low dose(850 MG) for 4 months. No exercise side effects. In fact, I lost my post-menopause belly and it has helped my cardio efforts and weights. Lowered my AIC. Thanks for answering my questions on Rapa... I will most likely explore this in a few years.. 1 Reply 2 replies @Irondukesteve @Irondukesteve 1 year ago As always, such a great video/podcast. Thanks so much Pete abs Matt. How would you compare these with the geroprotective effect of exercise? 9 Reply 2 replies @ricardomcvitie328 @ricardomcvitie328 5 months ago Wouldn't long-term use of rapamycin cause an adverse effect on the microbiome? 1 Reply @JuliMoodyStunts @JuliMoodyStunts 1 year ago I really like the assumption of knowing and improving the body organs is very important .. i was wondering how the fasting and adult athletes that have a very high consumption of food including the use of insulin and eating enormous amounts of food to generate more muscle . Does this have an effect for later ? I believe a lot of them become insulin resistant Any thoughts? I understand you only talking about the average population Reply @Philusteen @Philusteen 1 year ago (edited) Really curious if NMN / trans-resveratrol are moving the healthspan needle in a meaningful way. Lately I've been seeing things online that appear to throw cold water on Sinclair's research. I still take them, but.......is it worth it? 5 Reply 7 replies @TheShumoby @TheShumoby 1 year ago Attia keeps pushing higher V02max and higher muscle mass for longivity. I don't see many Olympians going on the list of longest living humans. 14 Reply 7 replies @crsp76691 @crsp76691 3 months ago Took the nad for a few years, noticed nothing felt like i was wasting money, should be just exercising more and eating better 1 Reply @557884368 @557884368 1 year ago I find it very disappointing that Dr. Attila limits access to his excellent podcasts to well-off people who can afford his very expensive membership fees.Very important health information is thus withheld from a section of the population that needs it most. Attia is a great doctor, scientist and communicator...but he is also quite arrogant. 13 Reply 1 reply @scottk1525 @scottk1525 1 year ago I still don't understand what an epigenetic clock even could tell us. For instance, if a given clock says I'm "40," say, does that simply mean I have the biomarkers of an average 40 year old? That sure wouldn't be good, because the average 40 year old, at least in America, cannot be confused for anything resembling healthy. Most middle aged folks are overweight, for instance. So does "40" mean I'm an unhealthy 40 year old? And what would that even tell me? Do we know how long unhealthy 40 year olds are likely to live? Or is it equally likely that an unhealthy 40 year old dies at 63 as it is that they die at 80? 3 Reply @ellinaras75 @ellinaras75 1 year ago Pretty sad that they chat about everything else except NAD, metformin and rapamycin 🤣 This video is the definition of clickbait 37 Reply 6 replies @peterking3131 @peterking3131 8 months ago Commercialization is growing in this field. David Sinclair leads this game on the borderline of fake. 1 Reply @larsnystrom6698 @larsnystrom6698 8 months ago I read the comments before viewing and realised seeing this would be a waste of time. Thanks commenters! 2 Reply @chrism2794 @chrism2794 11 months ago I am doing intermuscular injections of NAD plus and taking metformin. Anyone else combining? Reply 2 replies @melvinglick9446 @melvinglick9446 4 months ago You did not compare NAD,metformin,rapamycin or even discuss them. 2 Reply @ericwarmath1091 @ericwarmath1091 1 year ago Berberine acts like metformin for. Diabetics. Does it apply here? 1 Reply 2 replies @joshuacharette993 @joshuacharette993 4 months ago This title is inaccurate; why is this completely mislabeled? Reply @21972012145525 @21972012145525 1 year ago What are the inflammatory markers? Reply 1 reply @morganmacdonald5305 @morganmacdonald5305 1 year ago Wow. Really misleading title there Attia. Shouldn't be surprised though. The gross majority of his YouTube content is click bait titles that offer no definite advice on really anything. Just end up leading you to his paid content on his website 10 Reply 19 replies @f-authority6926 @f-authority6926 1 year ago CLICK BAIT TITLE! They didn't talk about any of the 3 in the title. Just rambled on abt epigenetic clocks- wgaf. I realize you're just a salesman at this point "doctor", but... jfc, nice credibility implosion. You copy other people's free content and then monetize it. Basically an MD onlyfans... 11 Reply 1 reply @naguarachamo1 @naguarachamo1 3 months ago When did we talk about rapa? Yikes Reply @amapolo7211 @amapolo7211 1 year ago Content has nothing to do with the title 3 Reply @boardcrf2763 @boardcrf2763 1 year ago The title is not accurate description for the content. 29 Reply 3 replies @ThatBritishVlogger @ThatBritishVlogger 2 months ago Found this video title misleading. Didn't see a conversation about any of the three specific drugs/supplements mentioned in the title. Seems that they are behind a pay wall. Ironic that the conversation talks about commercialising longevity research. 1 Reply @TheHankBurden @TheHankBurden 8 months ago Disappointing. I learned very little about the molecules mentioned in the title. How about the list of questions mentioned in the introduction? Nada. Reply @EddieCurran1 @EddieCurran1 4 weeks ago ????? Interesting i guesd...but an entirely different topic. Bizarre that u could give it a title and totally ignore the topic Reply @kbkesq @kbkesq 11 months ago More bait and switch from Attia. This is an intro to subscribe to his endless windbag videos for 💰 he won’t say anything here about the clickbait title meds. Look elsewhere 1 Reply @peggyfisher9743 @peggyfisher9743 1 year ago Interesting topic, but please allow me to suggest you don’t take so long to get to the meat of the subject. You took roughly the first half of the video to explain why you choose the subject you did. And then you suggested you were going to answer questions which I never heard because I stopped at the half way point. Way to much wandering for three obviously smart guys. 1 Reply @TheBiffsterLife @TheBiffsterLife 1 year ago Woo, sciency. Waste of time if you wants anything more than opinions. 7 Reply @NM-qc2dh @NM-qc2dh 9 months ago So. No Biomarkers for ageing. “Eye balling??????” What? How subjective is that? It is the most unscientific thing I have ever heard! 1 Reply @saijay5861 @saijay5861 3 months ago What in the world are you guys talking about? nothing about your video title. Stop wasting our time. 2 Reply @lisbeth.salander6743 @lisbeth.salander6743 11 months ago RIDICULOUS. NO SINGLE WORLD ABOUT NAD. BUT ITS IN THE NAME OF PODCAST. JUST NOT USEFULL BORING INFO. 2 Reply @GetNLine @GetNLine 1 year ago Clickbait 3 Reply @richardstillman9789 @richardstillman9789 2 months ago Clickbait 1 Reply