What is NAD+? 90,391 views Apr 29, 2021

What is NAD+? 90,391 viewsApr 29, 2021 2.2K DISLIKE SHARE DOWNLOAD THANKS CLIP SAVE Dr Matt & Dr Mike 334K subscribers In this video, Dr Mike explains what NAD+ and NADH is!?! 174 Comments rongmaw lin Add a comment... THELIFEOFPRICE THELIFEOFPRICE 9 months ago Been doing nad+ iv infusions a couple of times a month. Loved the breakdown you gave =D 19 conner rad conner rad 11 months ago I normally struggle with understanding chemistry, but you explained it in a way that was straightforward, but still easy to comprehend. I very much enjoyed this video. 17 Vivin Vincent Vivin Vincent 1 year ago doc showing his gains , vascularity and dropping knowledge bombs. cheers. 94 Адл Адл Адл Адл 1 month ago Mike, you are an absolutely amazing teacher! Please keep doing your job and we will support you! Dr Matt & Dr Mike Darkjestermayhem Darkjestermayhem 1 year ago New to the channel, thank you for making each and every one of your videos, they are well done, very informative and break down the subject matter in a very understandable, efficient and productive manner, my classmates and I are very grateful for your hard work and continued inspiration, the effort you put into your craft is very much appreciated and has helped to not only meet but to exceed our expectations, please keep up the great work Dr.😁 1 eloosivegem eloosivegem 7 months ago THANK YOU! I was struggling with the concept of NAD+ vs NADH but understood everything else in my materials. Thank you for breaking it down, you made it make sense!!! 3 Relissa D'Souza Relissa D'Souza 1 year ago Another amazing video!! Really love watching your lectures simply because of how you break down the concept and make it much more easier to grasp. Thank you sir! :) Kate Kate 1 year ago Phenomenal explanation! Wish I had this from an enthused professor about 12 years ago during my Microbio undergrad! 6 Stella Stella 1 month ago Hi Doc, I've seen some research on NAD+/NADH and the potential anti-aging benefits... could you comment on that? and also would it make a difference in whether you take NAD+ or NADH supplements? I also read in some journals that the NAD+/NADH ratio changes as we age but I'm not sure if there is enough research to support that... your input would very much be appreciated!!! 1 Srijanee Dhar Srijanee Dhar 9 months ago I have been struggling to understand the process , thank you so much. This video is outstanding. Dr Ashok Kumar MBBS Dr Ashok Kumar MBBS 2 months ago Excellent narration of complex topic in very easy manner ..respect🥰 2 Cab Abc Cab Abc 8 months ago Wow, you've cleared all my doubts Thank you 😊 3 Kara Langley Kara Langley 2 months ago Wow, finally understand why I’m getting energy from my NAD+ boosters. Living the fasting and NAD boosted life!! Love this video, thanks!!! 2 Brendan O Brendan O 2 months ago Outstanding lesson. Thank you. Katrina Johnson Katrina Johnson 2 months ago What the heck, how did i understand all that?! Thanks for the lesson Dr Mike. That was Brilliant 2 Dr Matt & Dr Mike Mudassar Hussain Mudassar Hussain 6 months ago You nailed it, bro. Thanks a lot, I understood it the first time in life. 1 Acoustic Motorbike Acoustic Motorbike 6 months ago That was so well explained and I still didn't grasp it completely. I understand the outline and will have to watch again. But great simple explanation. 1 yoe91 Rugby yoe91 Rugby 5 months ago Thanks for this. My virtual classes are in french, but this was easier to understand in english lol. Straight to the point. 1 BIOS:VR BIOS:VR 5 months ago Thank you for this video. It was incredibly helpful. شيماء صلاح شيماء صلاح شيماء صلاح شيماء صلاح 7 months ago The BEST explanation. Exactly what I wanted 2 Joe Silkwood Joe Silkwood 6 months ago This Guy has a gift of explaining things!! Jocelyn Joseph Jocelyn Joseph 6 months ago (edited) Thank you🌹.it's easier to understand when the marker and white board is used since we get time to see and grasp what is explained. 1 JOSHUA CORONA JOSHUA CORONA 10 months ago WOW! VERY TECHNICAL, BUT CLEARED TO UNDERSTAND 1 ここあ.丸かじり ここあ.丸かじり 6 months ago 生物の講義を聴きながらリスニング対策もできるという神授業 Tris Tris 1 year ago You explained it so well! Not even a person with PhD could do it like that! Thanks! 11 Zakir Zak Zakir Zak 1 year ago Thank you 🙏... very good explanation 1 danjbro danjbro 8 months ago (edited) Rewatching! 👀 Current graduate student that has had a 10 year gap between undergraduate and now - never hurts to brush up on the basics. And guns! 😆 1 Dr Matt & Dr Mike Amina Kaja Amina Kaja 7 months ago Wowza, loved this video and the great explanation! 😊 3 Cole Young Cole Young 4 months ago I’ve have never seen one of your videos, Nice job breaking it down. Thank You! Guthrie # 1 Guthrie # 1 4 months ago (edited) I took 260 mg of nicotinamide adenine dinucleotide and it was no placebo. Increased energy, mood, and focus all day long. I’m going to proceed with caution until more research is done on its tumorigenic potential and impact on sirtuens, but damn. I’m not going to name the manufacturer in case someone thinks I have a vested interest, but this stuff works. Obviously consult your doctor before taking any supplements. 3 Edward Bennett Edward Bennett 5 months ago Best explanation I’ve see yet 2 Drew Drew 1 year ago Excellent video! I take NAD+ as a supplement! According to many studies, it is likely to be beneficial in human longevity! 2 james2488 james2488 1 year ago I have no idea what any of that means, but it sounds important, so I’m glad it happens I suppose! 27 정만지 정만지 10 months ago Can human manufacture the NADH artificially in vitro? Could we eat NADH by the form of a pill? My son can't metabolize long chain fatty acid because of a lack of long-chain acyl-CoA dehydrogenase. 1 Eden Sun Eden Sun 1 month ago PERFECT explanation Deborah Davis Deborah Davis 10 months ago I am curious to know if all that energy is transformed into a manageable non-anxious energy or if it creates more anxious energy for a person that already has anxiety. I've tried a lot of therapies that just increase my anxious energy....although it gave me more energy. I couldn't handle the increased anxiety that came with it, so I stopped trying. This was very helpful information. Thank you. Travis Travis 6 months ago Wish I could find an IV clinic that does this! Hopefully the supplements are not just a waste of money. 2 Ali Al Attar Ali Al Attar 4 months ago hope you do more biochem vedios ,cz its really help 2 Puranjay Jadeja Puranjay Jadeja 3 months ago Hi Dr.Mike, wanted to know what finally happens to NADH, is it eliminated or recycled ? Brendan O Brendan O 2 months ago I have questions on increasing out nitrogen uptake. How may I submit my questions please? Ben B Ben B 1 year ago Excellent! Thank you 1 Hassan Malik Hassan Malik 5 months ago I have 3 weeks study carbs and i dont understand this until in found this video , thankssssss 🥳🥳 1 Jason Sasman Jason Sasman 8 months ago HOw did he make something so complex........seem so simple!?!? And his bicep gains is amazing! Well done Doc! 2 RA6162 RA6162 8 months ago (edited) It a DAM ! A reservoir of Proton (water) is made to travel down from high concentration (reservoir) down to a low concentration (below the dam), and in the process ATP is produced (Electricty from the turbine in case of a DAM using water) ! - Dr Mike you are a Genius ! 1 Dr Matt & Dr Mike P. Godwin P. Godwin 7 months ago Great info 💪🏼💪🏼 1 Barbie Cardenas Barbie Cardenas 10 months ago LOVE IT ;) you make me feel awesome thank you :) Andrew Bliss Andrew Bliss 7 months ago Supplements NAD, NR, NMN, NAD+, NADH…. all ultimately doing the same thing? Any of these the better choice? 2 BTS Niki BTS Niki 3 weeks ago Thank you so much! 1 Shamsul Shamsul 5 months ago It was so easy and amazing concept based, I wanna know why 1 proton not hogging its letting free? Tenbite Ermias Tenbite Ermias 3 days ago You explained briefly thanks MARTZ MARTZ 3 months ago i like to be those electrons.. be hugged.. just kidding. thanks for this lecture, its helping me understand more the processes involved in cellular respiration and more.. Tessa Cyclone Tessa Cyclone 2 weeks ago (edited) How do we first make NAD ? So that it's floating through the body as you said at 0:46 N02tradamus N02tradamus 11 months ago How does lactate connect in this chain? ecwilliams777 ecwilliams777 1 month ago This doctor actually looks like someone I would listen to about health. I look at most doctors and I'm like "nope, you look disgusting and very unhealthy. Not listening to anything you try and tell me" 1 Robert Novoa Robert Novoa 6 months ago (edited) How about "NMN" 🥦 supplement along with resveratrol 🍇 supplements, isn't this a faster way?🙄 1 Joni Svanidze Joni Svanidze 2 months ago ძალზედ სასსსიამოვნო მოსასმენი იყო მაიკ კაი კაცი ხარ <3 Anne williams Anne williams 1 month ago Young individuals should take Resveratrol at night while older people should take it midday for the greatest effectiveness. If you’re 40 or above, I suggest you to take NMN. Just so you know, Resveratrol is needed to activate the sirtuin genes (which protect our DNA and epigenome), while NMN is needed to fuel the sirtuins. However, resveratrol is difficult to be absorbed by the gut, and the little resveratrol that ends up in the body is broken down very quickly. I take NMN Vitruvin brand for the first time, and so glad it didn't fail me. Justin Cody Justin Cody 11 months ago 3 months of NAD IV Therapy and micronutrients now and zero complaints! First 8 weeks - 1x a week. Now once a month. 2hr drips . 😎💪✨💫 Fat Moogle Fat Moogle 7 months ago I know you used glucose as an example, but what if you are doing keto and using fat as your fuel? Does it work the same way? 1 Genesis Ansbro Genesis Ansbro 6 months ago Is it a coincidence that this video was recommended to me after watching Tim Pools experience with COVID?? 5 Darth Swahl Gaming Darth Swahl Gaming 7 months ago Doc lookin jacked and jacked on science too. Love it! Thanks for the info 3 KatynMermaid 187 KatynMermaid 187 1 month ago 0:55 Is the H in NADH positive- I mean, does the NAD snatch the two elections like in an ionic bond and the the H is actually an H+ just hanging on the anion NAD -? althaf althaf 5 months ago Very very useful video sir 1 Nameless Blob Nameless Blob 1 year ago This man can split me in half. Sploosh 2 wampastompastomp wampastompastomp 4 months ago now I finally know where that H and e- come from to add to NAD area859 area859 1 month ago Continuous replenishment of NAD promotes the proliferation and survival of fast-dividing cancer cells because elevated NAD levels enhance glycolysis via glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and lactate dehydrogenase (LDH) that require NAD as a co-enzyme (12, 13).Dec 12, 2018 badmoon rising badmoon rising 2 months ago So why is NAD+ better then sugar. Does it not have all the bad effects of sugar? If not, how. Cynthia Monêt Cynthia Monêt 4 months ago Is it safe to take while pregnant? Bob Lemon Bob Lemon 5 months ago Yes, nice Job. You should be a teacher. Yasmin Sierra Yasmin Sierra 1 year ago You're the best 2 Ishan Ishan 4 months ago Already knew all this but what the hell he has got them gains 1 Martin Tippins Martin Tippins 3 months ago So NADH gives away 3 electrons and four protons? Then what are you left with? I don't get it. Quốc Thái Quốc Thái 2 months ago thank you! Γιωργος Παπας Γιωργος Παπας 2 months ago Is 200mg NAD+ ok daily??

NAD+

NAD+ in Aging: Role of Nicotinamide Riboside and Nicotinamide Mononucleotide 476,603 viewsPremiered Jan 28, 2020 13K DISLIKE SHARE DOWNLOAD CLIP SAVE FoundMyFitness 421K subscribers In this episode, Rhonda explains what NAD+, why it is so important for aging and why it declines with age. She discusses some of the popular NAD+ boosters like nicotinamide riboside and nicotinamide mononucleotide, what animal and human data says and some concluding thoughts. NAD+ is crucial for our survival. Small amounts of it can be obtained in the diet, but the body recycles it to get most of what it needs. Unfortunately, day to day living plus normal aging can cause NAD+ levels to drop. This causes metabolic and mitochondrial dysfunction, as well as many of the other problems and conditions associated with aging like elevated DNA damage. NAD+ levels can go up when we exercise or fast, but NAD+ precursors like nicotinamide riboside and nicotinamide mononucleotide can also increase NAD+ levels in a dose-dependent manner. However, most of the data on NAD+ boosters comes from animal studies. Whether these boosters are effective – and safe – long-term in humans is still a big question. ▶︎ Get the episode's show notes, timeline, and more https://www.foundmyfitness.com/episod... Chapters 00:00:00 - Introduction 00:01:01 - Aging 00:02:47 - Overview 00:07:35 - Depletion 00:09:19 - Supplementation 00:11:26 - Animal studies 00:13:47 - Cancer 00:15:57 - Dosage 00:25:44 - Human data 00:28:25 - Storage 00:29:00 - Recap ▶︎ Detailed overview of NAD+ https://www.foundmyfitness.com/topics... ▶︎ Detailed overview of nicotinamide riboside https://www.foundmyfitness.com/topics... ▶︎ Detailed overview of nicotinamide mononucleotide https://www.foundmyfitness.com/topics... ▶︎ Did you enjoy this podcast? If you want to support me in getting more of this free information out to the public, please consider becoming an FMF premium member! In doing so, you'll also get access to exclusive member benefits, such as a private podcast feed offering early access and occasional bonus episodes, monthly live Q&As with me, a members-only library that includes presentation slides with all of the supporting figures, graphics, references, and quotes. Also included are Rhonda's private notes on topics discussed in the podcast, bi-monthly member-exclusive Science News Digest email, and more. Thank you for your consideration! Learn more here: https://www.foundmyfitness.com/premium ▶︎ Gain valuable insights by running your raw genetic data through the FoundMyFitness report https://www.foundmyfitness.com/geneti... Chapters Introduction 0:00 Aging 1:01 Overview 2:47 Depletion 7:35 Supplementation 9:19 Animal studies 11:26 1,246 Comments rongmaw lin Add a comment... FoundMyFitness Pinned by FoundMyFitness FoundMyFitness 2 years ago (edited) 00:00:00 - Intro. 00:00:48 - Nicotinamide riboside supplementation in humans has been shown to raise NAD+ levels in white blood cells. 00:02:47 - Overview of NAD+ 00:05:12 - NAD+ plays an important role in mitigating DNA damage. 00:05:30 - Excessive DNA damage can decrease NAD+ levels by 20-30%. 00:05:42 - Lymphoblastoid cells from centenarians show increased PARP-1 activity. 00:05:55 - Between different species of mammals, higher PARP-1 activity is strongly associated with a longer lifespan. 00:06:36 - Lower organism evidence: A second copy of SIR2, a yeast sirtuin, gave rise to a 30% extension of lifespan. 00:06:43 - NAD+ is required for the activation of sirtuins, which epigenetically regulate a variety of stress response-related processes. 00:07:03 - Energy stress, such as from fasting, exercise, or caloric restriction, increase the NAD+:NADH ratio. 00:07:37 - NAD+ becomes depleted in the brain, heart, and skeletal muscle as we age. 00:08:13 - Decline in NAD+ levels have been associated with many broad categories of clinical disease such as neurodegenerative, cardiovascular, infectious, musculoskeletal. 00:08:48 - NAD+ supplementation has been shown to increase lifespan in models of aging in yeast, worms, and rodents. 00:09:48 - In contrast to de novo synthesis, the predominant source of NAD+ in the body is via the salvage pathway, which is subject to feedback inhibition by nicotinamide. 00:11:56 - Animal studies have shown nicotinamide riboside supplementation is able to increase insulin sensitivity, increase endurance and strength, reverse mitochondrial damage, increase mitochondrial biogenesis, and reverse muscular atrophy. 00:12:30 - Nicotinamide riboside has shown positive effects on the brain in animal, such as increased neurogenesis, decreased cognitive deterioration, decreased amyloid-beta production, and increased synaptic plasticity. 00:12:50 - Nicotinamide mononucleotide has been shown in animals to counter an obesogenic diet, improve markers of metabolic health, improve heart function, and improve cognition and memory. 00:13:10 - A 12-month dietary study of nicotinamide mononucleotide suppressed age-associated body weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and plasma lipid profile, and ameliorated eye function and other pathophysiologies in mice. 00:13:47 - NMN has been shown to increase cancer progression in a specialized senescent cell-dependent pancreatic cancer model in mice. 00:15:57 - Plausibility of dosing: comparing animal and human doses. 00:18:05 - Tissue-specific metabolism and bioavailability of NR and NMN. 00:24:32 - Oral administration of NAD produces NR and NMN in the intestine. 00:24:19 - Intravenous administration of NAD, rather than its precursors, shows interesting results: an increase of NAD content and sirtuin expression in the hypothalamic region of the brain. 00:26:15 - Human study #1: 250mg of NR + 50 mg pterostilbene increased blood NAD+ levels by 40%, while a double dose (500 mg NR + 100 mg pterostilbene) increased blood NAD+ levels by 90%. Additionally, there was a decrease in blood pressure, and ALT (a marker for liver health). 00:27:12 - Human study #2: 500mg NR twice daily for six weeks increased NAD+ levels in white blood cells by 60%. 00:29:08 - Concluding thoughts and recap. 248 pablopolski pablopolski 2 years ago Concise, comprehensive, and articulate. I don't even need to speed it up to get through the information. Well done. 367 FoundMyFitness Chuck A Chuck A 2 years ago Congratulations Rhonda you have smashed the record for total mentions of "Nicotinamide and Nicotinamide Mononucleotide" without stuttering, giggling or entering a comatose state. Kudos! 178 Chris Benton Chris Benton 2 years ago Excellent lecture, well put together, a good balance of pros and cons, useful diagrams and a clear summary at the end. Perfect presentation technique. 109 FoundMyFitness Rich Rozmarn Rich Rozmarn 2 years ago Great presentation, thank you so much. I take NAD with R-Lipoic acid, D-Ribose and Resveratrol for a pre workout. I work out 3-4 times a week and feel as good as when i was 40, now 60. 48 DAVID EVANS DAVID EVANS 2 years ago (edited) Rarely do we find in the study of nutrition, detail like presented in this video, yet at the same time Rhonda is able to get to her final conclusion without leaving everyone in the weeds. Extremely well done. Combined with Dr. Nicholas Pericone and Dr. Jason Fung, we are starting to get a handle on what is necessary to make critical changes in our life for optimal health... 5 Dr. Nancy McClure-Galli Dr. Nancy McClure-Galli 2 years ago So great to have the micro cellular pathways broken down this way. Also, the analysis of both animal and human studies. Thank you so much for the effortless way you explain potentially mind boggling processes. Helps so much in the decision making process. Scott Joshua Scott Joshua 2 years ago What a herculean effort and a testament to your ability to grind it out for hours on end. You’re incredible Rhonda. 14 FoundMyFitness No Limit No Limit 2 years ago A very professional very well presented lecture . English is my 4th. language and I did not have any real problem to understand it and learn from it. Doc, I really appreciate your effort to create this video. Thank you. 5 FoundMyFitness Cat Man Cat Man 1 year ago I've been taking a low doseage of NMN for a couple of weeks now. I started with 100mg in the morning and 50mg at night on the first day, then 50mg the next morning. I hadn't been expecting any results for at least a week or so. About 2 hours after taking that second morning dose I went out shopping and was astonished to find my legs wanting to walk faster and faster, as if under their own volition. I've not walked like that in almost 7 years. I've had a number of strokes and suffer numerous symptoms, manly to do with inhibitted activity levels. My mind is foggy most of the time and the NMN has not done anything for that, but I certainly feel the difference in energy levels, it's really amazing. I also found that after a few days I had to stop the NMN for a couple of days as it seemed to be making me feel more groggy, so I now take it 2 days on, 2 days off. The brand I'm using is an American Brand called RevGenetics, and it's called Advanced NMN, in capsule form. I know it's also available in powder form too. It's quite expensive even in capsule form and would cost the earth to take it regularly at the doseages recommended in this video, but I can assure anyone that the effects at the doseage I am on are truly amazing. 1 Tony Westbrook Tony Westbrook 2 years ago I learn so much here by your presentation and documentation. Thank you Rhonda for taking, what must be a lot of time to put all of this documentation together! 27 FoundMyFitness quigonreturns again quigonreturns again 2 months ago Hello! Would love to know your thoughts on methyl group depletion as it relates to Niacinamide supplementation. I have been taking it at 500mg/day, with no ill effects. However, I am cautious about the long term affects of supplementation. Thanks! And love your content! Dustin Phillips Dustin Phillips 2 years ago Thank you for the video. I have been taking Tru Nigen (NR) for about two months at 350 mgs. What I have noticed is a slight increase in energy, and focus. I feel like I have also lost some body fat. However, I stay in Ketosis and use intermittent fasting 4 days a week. However, I plan to stop taking it once my bottle runs out because of the information presented in this video. I don't see the benefits outweighing the potential downsides. Thanks again. 10 profitfever profitfever 2 years ago So glad you covered this. Been listening to lifespan on audio book and he's one of the leading scientists on this research. 8 David David 2 years ago Great video Rhonda, thank you for all you're doing and the quality information with such strong scientific detail. 2 N C N C 2 years ago I've been doing lots of reading and this is by far the most in depth breakdown I've seen on NR/NMN yet. While I am really impressed with anecdotal evidence of NAD supplements, I am erring on the side of caution. Personally, I'm going to hold off on purchasing supplements until more clinical trials come out so we know proper dosages and whether or not this even carries over from mice to humans. Anyone else feel the same way? If it turns out this is safe, easily replicates in humans etc then I will consider supplementing. 1 Ramon Mensink Ramon Mensink 1 year ago Great video Rhonda! I was wondering if it makes sense to take a NR/NMN supplement while also ingesting carbs/protein/fat. As you also explain in the video, the NAD/NADH ratio in the cell increases when fasting/CR/exercising. Then such a NAD boosting supplement would need to be taken in a fasted state wouldn't it? Or is the pathway of either NR/NMN supplement somehow separated from the metabolic pathway when a cell is in a fasted state? 1 Steve Wright Steve Wright 1 year ago Many thanks for this detailed walk through! I think correctly identified this is all at an early stage of discovery - perhaps usefully highlighting the key importance of NAD in the cell energy economy, but (to my mind) now pointing to the need to reduce NAD depletion. A whole food plant based (WFPB) diet being inherently low inflammation - perhaps best indicated by White Blood Cell count: https://nutritionfacts.org/video/what-is-the-ideal-white-blood-cell-count/ Also points to a need to remove senescent cells regularly - probably by a number of 5 day water fasts over the year. Lastly - not a bad shout to pay attention to Vit B3 status - if this is insufficient NAD production is likely to be throttled... Thanks Rhonda for this review - appreciated! KenG KenG 4 months ago Excellent analysis and much appreciated! I love your presentation speed and style! 1 Harvey Holloway Harvey Holloway 2 years ago Great video. I am 70 and a health fanatic, and still in perfect health. I have a massive coordinated program that did not include this. Now I will be going out today and buying Niacin. I am going to start immediately. Have a wonderful day. ☺😎🐰 4 Rob Lovegreen Rob Lovegreen 2 years ago Because of you, I started loving myself with broccoli sprouts. ❤️ I grow them too. Sulforaphane for the win! Thank you 🥦 59 Morrocco Method Int'l Morrocco Method Int'l 2 years ago So helpful + informative for learning about aging. Thank you for this video! 2 Joseph Khadige Joseph Khadige 1 year ago Great presentation Doc. Thank you. Please excuse my ignorance in this matter but to make sure I am understanding it accurately, if a cancer patient is regularly fasting and exercising (which leads to increase of NAD levels) would that increase the spread and developing of the cancer cells? SpockBoy SpockBoy 2 years ago (edited) Thank you so much for bringing us this information Doctor. Using your great intelligence for altruistic purposes is both rare and wonderful. 3 gururaj bsavakar gururaj bsavakar 2 years ago Congratulations! Firstly for the , pleasant, patient presentation, with amazing revelations of test results of NAD, decline with age, using boosters of NAD, & Alternate pathways which work usually but with exceptions!!! Extremely A Great MASTERLY STUDY/ & presentation of all pros- cons of all eventualities . With a final recap!! Thanks for this useful educative share! Many regards! 4 FoundMyFitness Cris Clourt Cris Clourt 2 years ago Thanks Rhonda for your amazing research! Do you know what type of trans-resveratrol is best? Does it have to be organic etc...? 2 jackwelshh100 jackwelshh100 2 years ago (edited) Very interesting episode. Fantastic work! One question comes to mind: We know that resveratrol is a SIRT-1 activator but are there identified compounds that increase PARP-1 activation (for us with non-supercentenarian genes)? I supplement with NR and resvetral. If there's a PARP-1 specific activator compound, it might be an interesting addition to the mix. 4 Andrew Moore Andrew Moore 1 year ago Superb. So much information explained so efficiently in 30mins. I feel very well informed now, thank you! 1 Gregory Colvin-Garcia Gregory Colvin-Garcia 1 year ago Rhonda, I've heard Dr. Sinclair say he takes 1gram of NMN daily but in reading his book and listening to multiple interviews I'm not sure on the best time metabolically to dose and if there is a "minimum effective" single dose. Currently, I take 250 mg, 3 to 4 times per day sublingually but it occurred to me that each one of these single doses may be below the threshold of effectiveness... 2 B Szlado B Szlado 2 years ago Great summary of the topic! I was desperately trying to find actual human published data about NAD+ decreasing with age, but other then the two studies you mentioned, couldn't find much. In those two studies though, sertuin activity actually didn't decrease; there was significant difference between men and women, and the NAD+ decrease was extremely small (vs. the 50% David Sinclair commonly mentions), and in fact looking at the graph, it was quite variable, with some 30 year olds having the same level as 60+.. .so I really wonder if the marked "decrease" in NAD+ everybody goes on and on about is actually a comparison of an active 20 year old vs. a sedentary, unhealthy 50-60 year old; ie. isn't the life style more important than the horrendously expensive NMN and NR supplements? Karla Jean Karla Jean 1 year ago 5 months later and I'm still coming back to relisten to this video. Very informative and so well put together. 2 Vedran Simic Vedran Simic 2 years ago Very interesting. From your video's from Satchin Panda I learned the benefits of time restricted eating regaring insulin sensitivity, sleep, cardiovascular aspect etcetera. Do you have any information whether NAD+ increases also with time restricted feeding and which window of eating you should use? Or is there only information about fasting and increasing NAD+ and if that is the case how long you should fast for increasing NAD+. 1 a2audrey a2audrey 2 years ago I’ve been taking 750mg of NMN + 500mg resveratrol for 6 months. I’m 61 and in good, but far from great shape. My muscle stamina and overall energy are way higher than when I began. I also have noticeable reduction in inflammation in my leg that was damaged in an accident and where it had been chronic for many years. The reduction in inflammation alone keeps me on it, but feeling a lot better is great too. 42 Kuo-Ying Wang Kuo-Ying Wang 4 months ago Excellent and brilliant work. Thank you very much indeed. The literature reviewers are amazingly detailed and strikes the key points of the findings from the researches. Ken Otwell Ken Otwell 2 years ago Great data - but leaves me with one big question - how much does exercise increase NAD+ and how does that compare with supplementation? Also - is there any synergy between exercise and supplementation? 64 Ja Wi Ja Wi 2 years ago Good work! You certainly did the research and can explain it with great accuracy. Thank you. pravoslavnik pravoslavnik 2 years ago Just found your channel/videos. Your presentations are "spot-on," as the modern expression has it. Loaded with information. Love your vids. I shall be watching them all. PLEASE keep up the good work ! 2 FoundMyFitness Noveleffect Noveleffect 2 years ago I really appreciate the chemical reaction explained to me along with the reaction diagrams. So rare to find anything this thorough 4 Cuenta de Youtube Cuenta de Youtube 2 years ago Best unbiased recap of NAD+, NR and NMN. Thank you! Suscribed! 3 Tom Provan Tom Provan 2 years ago This is definitely the best most informative and comprehensive piece of information so far delivered on this topic as far as I am concerned thank you for this video Wolfram Luchner Wolfram Luchner 2 years ago Exemplary summary. I love how dense with information your videos are. Quite a rarity on youtube! Keep up the good work and thank you for your high quality content! 7 FoundMyFitness uncle Joe uncle Joe 2 years ago Exciting developments. Great to know scientists are working so hard on our behalf in this crazy world. In the meantime I'll continue my exercise, sauna, and clean diet. Thanks! 1 alfred Vincent alfred Vincent 1 year ago Great concise presentation as always. Thank you. 2 Roger Bowman's Fitness & Wellness Coaching Roger Bowman's Fitness & Wellness Coaching 1 month ago Stellar presentation as always, thank you Dr. Patrick! Aldous Orwell Aldous Orwell 2 years ago Beautiful! Very comprehensive! Question: does DNA repair have a circadian rhythm? If so, would it be better to take NR in the evenings? Thank you! :-) Jeff G Jeff G 2 years ago Great video. Now I'm wondering how long it will be until we have solid data on positive effects as well as dosage sizes and methods to experience those effects. Years? How many? Equs Narnd Equs Narnd 1 year ago I'd like to see you do a video on the role of Niacin (Nicotinic acid) on supplying the molecules for the manufacture of NAD+ 11 June Allison June Allison 1 year ago Dr. Rhonda this is the best explanation I've heard on this topic. So thorough and well thought out. Thank you❤ 2 Larry Tate Larry Tate 2 years ago Dr. Patrick thank you for sharing your knowledge. Could you please consider doing a video lecture on CBD and it’s benefits and possible negatives? Thank you B D B D 7 months ago (edited) Excellent!! Conclusion: Fasting, less calories, regular exercise increases NAD level👍 We all need to wait for using supplement at this point till more data available! Bakhtiyar Neyman Bakhtiyar Neyman 2 years ago Instantly one of my favorites videos on Youtube. Thank you so much, Rhonda! 2 carpe diem jonah carpe diem jonah 2 years ago (edited) So what are the best relative food sources of NMN? And the best relative food sources of Nicotinamide Riboside? Are some of these foods significantly higher in their capacity to boost NAD levels? Hoping to get it aboard the food supply so there is the safety of letting the body metabolize as needed. Optimize with Science Optimize with Science 2 years ago It is a fascinating topic and I love how scientific Dr. Patrick approaches it! 41 FoundMyFitness Konstantin Yavrichev Konstantin Yavrichev 1 year ago Congratulations 🎊 - It's pretty rare to be able to see such good quality presentation for so complex topic and compressed in so condensed time 1 Casey Connor Casey Connor 2 years ago Fantastic as usual! Thanks for the great information! Hey, if you get a chance to circle back on the subject of eating fresh ground broccoli seeds at some point that would be great. Many of us like the taste of them! Or don't notice it when added to food! Erucic acid might be a consideration? Thanks! 2 Dan O'Hanlon Dan O'Hanlon 1 year ago Very helpful — comprehensive — much appreciated! 2 Ivan Valdez, PhD Ivan Valdez, PhD 8 months ago Fantastic job, Dr. Patrick. Do you think that sublingual NR/NMN would be effective at increasing NAD+ levels in different tissues And not just blood, similar to Intravenous administration, by bypassing the liver? Rick Kowalchuk Rick Kowalchuk 2 years ago It seems to be a key component involved in aging and possibly reversing the process! C H C H 2 years ago (edited) Regularly growing broccoli sprouts for a couple months now, I put them in my daily smoothies for myself and my family thanks to Dr. Rhonda Patrick. Thank you for all this free info, truly is life changing 36 FoundMyFitness David Alzate David Alzate 8 months ago I guess in the section on depletion, it's important to include the studies of CD38, CD157, and PARP. These molecules are impacting the depletion of NAD+. Isabella Holden Isabella Holden 2 years ago Amazing video. Thank you for the brilliantly explained content.🇿🇦😎🙏 4 FoundMyFitness rzomg rzomg 2 years ago Amazing skills to flood my brain with huge amounts of information. I know how its gonna feel when AI's are smarter than us all its the same feeling I get when I listen to Dr.Rhonda 2 Ron RG Ron RG 1 year ago Dr. Rhonda amazingly insightful analysis of the data! Love the topics and videos you make . Thank you so much 1 Dr. Steve Hruby, D.C. Dr. Steve Hruby, D.C. 2 years ago Thank you Dr Patrick this is above and beyond anything that is out there. 1 FoundMyFitness SmartCookiesDontCrumble SmartCookiesDontCrumble 1 year ago Thank you so much for giving this teaching on this topic. Valuable information!🥰 2 Christina Lawhorn Christina Lawhorn 2 years ago ** Due to a serious case of mold poisoning I have been on NAD+ IV's for 6 months... they literally saved my life.. I have never had oral NMN or NR. However I would highly recommend anyone with a health issue try NAD+ IV's. There are numerous accounts of people turning their life around due to NAD IV's not precursors. Best wishes to each of you! 1 firehorse_44 alpha-omega firehorse_44 alpha-omega 2 years ago Excellent lecture. Thank you for this presentation Dr. Cheers 10 Ro Bo Ro Bo 2 years ago Wow talk about informative video thank you , I’ve been taking a product which contains Nicotinamide 250 mg twice a day with botanical mix alpha lipoic acid vitamin c and zinc which apparently works on the salvage pathway you have described. The company claim that Despite all the hype surrounding the use of precursors such as NR and NMN to boost NAD+, our cells actually make nearly all of the NAD+ they need using NAM ,as you described in your presentation. They go on to say That “as we get older, levels of the NAMPT enzyme are known to decline and the salvage pathway becomes inefficient at converting NAM into NAD+. In fact this is known to be one of the main reasons that cellular NAD+ declines as we get older. This means that if we want to make sure that NAM doesn’t build up in the cell, then we must make sure that NAMPT and the salvage pathway are working optimally, like they were in young cells. Rather than simply trying to fix falling NAD+ levels by putting more raw material into the cell (using precursors) the product is designed to fix the underlying reasons why NAD+ is actually declining, namely the failing salvage pathway. I am however concerned of the effect of Nicotinamide on sirt2, they claim however that Nicotinamide does not effect sirtuins if it doesn’t hang around for a long time when the salvage pathway is working properly . I just wondered what your thoughts are on this. Again many thanks for your very detailed video 2 Entropy Wins Entropy Wins 2 years ago I'd be interested in a video on pterostilbene and thoughts on supplementing that. Thomas 3108 Thomas 3108 1 year ago Hello, I have one problem taking NMN. Hope you can help with your knowledge 😃🙏 I take 0,5 - 1 gramm Resveratrol in Oliveoil, 0,5 gramm of NMN and 1 gramm of TMG. I started taking TMG as I noticed, that after about 3 days I feel a certain pressure on my heart or let's say on the left side of the breast and I feel like having higher blood pressure. Then I stop the life extension treatment and everything is fine again. When I take only Resveratrol or only TMG this phenomenon doesn't appear. I thought with taking TMG this would stop, but that's not the case. After starting again the same reaction appears. I bought NMN even from Prohealth. The same thing. The dose is really not that high, so I am wondering as the studies don't have such results. I am 45, 1,75 m and about 83 kg. So what's your opinion on that? Thanks in advance, Thomas 1 AJ Hege AJ Hege 2 years ago Appreciate the info! What are your findings about NADH (NAD bonded with a hydrogen ion)? I hear it has a better delivery system from a doctor on the Ben Greenfield podcast. Chad Aitken Chad Aitken 2 years ago Thanks for the effort on the video. Can anyone get the Parp-1 activity level test? Do we know what happens in the Salvage pathway recycle that lowers levels as we age? I seen reports that % gains is not good enough in older people since it’s so low? Dr. Michael Moeller Dr. Michael Moeller 2 years ago I personally get NAD IVs@24:30 and use them with my patients and notice an increase in energy and improved cognition. 31 Kunverji Hirani Kunverji Hirani 1 year ago Hi Rhonda :-) So practically, what do you recommend? Take NMN first thing in the morning? - then how long should you wait before having breakfast? Or can you have breakfast straight away after taking NMN? Many thanks :-) MrVeteranhawk MrVeteranhawk 5 months ago I did 10 push ups for every time she said NR or NMN, I don't have to workout until the year 2023 now..lol. But great presentation, very helpful for my age at 52. I've been doing a lot of research on taking supplements to increase NAD+ 1 Stephen Hurst Stephen Hurst 1 year ago Thank you so much for the thorough long-form video, all of this information is very important. 1 McJagger McJagger 1 year ago I started taking 250-500mg of NMN sublingually for a few days and felt really great and energized, but then it suddenly started making me exhausted and sleepy. This happened within 1 week’s time. It caused my grandmother on first usage to sleep all day after taking it in the morning. I can’t find much info on this effect. Waskel E. Wabbit Waskel E. Wabbit 1 year ago (edited) I have been taking 300 mg a day of NAD+ for almost a month. Took about three weeks before I started noticing a difference. It is very subtle but that might be a good thing. There's a fine line between feeling like doing something or not. I have had chronic fatigue for all of my adult life. I am 68 now. Been looking for the magic pill for that long. Getting ready to order my second bottle and I would recommend to anyone with low energy levels or just to possibly live longer. No one I've talked to has heard of this stuff. Would like to get some friends to try it to see if it helps them too. 1 Anh Nguyen Anh Nguyen 2 years ago Thank you for such an educational clip . Please keep it up 3 NADIOL™ NADIOL™ 7 months ago Amazing content as always Rhonda. B K B K 2 years ago Amazing video, thanks for the in depth overview! I've been following NMN for a while now, and this is the best video I've seen to date, covering every aspect, concisely. Absolutely amazing. Now if only supplimenting NMN wasn't so cost prohibitive. 😅 I'm up for being a long term study if anyone needs a test case. 🤔 I've got about two years worth of detailed food logs, heart rate, sleep logs, weigh ins, blood work, exercise, and the likes, that I'm farming up anyway as part of my commitment to getting fit. I wouldn't mind sharing with actual doctors and scientists. 😋 🤷‍♂️ Either way, thanks for the awesome info! GLHFDD! ✌️😈 7 Josh Woodle Josh Woodle 2 years ago (edited) Dr. Rhonda, since Dr. Jed's video, I've been eating just the broccoli seeds. Is there any way you could do a video on consuming broccoli seeds vs. sprouts? I burr grind them and sprinkle over food. Very interested in this! Bart Bart 2 years ago Thanks for the good video! I was wondering where is the source for the statement that NAD is lower in older human muscle compared to young. Does this data exist? 2 Nathan Nathan 2 years ago Great video, thank you for quality information! 2 Erin Greer Erin Greer 2 years ago Thanks for so much important information. I hope more studies in humans are coming. Launch Medical Media Launch Medical Media 1 year ago

Intestinal Permeability: the Bacterial link to Aging, Brain Barrier Dysfunction & Metabolic Disorder 26,184 views Premiered May 31, 2022

SANTA BARBARA Intestinal Permeability: the Bacterial link to Aging, Brain Barrier Dysfunction & Metabolic Disorder 26,184 viewsPremiered M FoundMyFitness 421K subscribers The intestinal barrier serves as a gatekeeper to the human body. The loss of the health and integrity of this barrier influences multiple aspects of human health – including cardiometabolic function, neurological health, behavior, and more – in surprising and possibly unexpected ways. One of these ways involves lipopolysaccharide, or LPS, a bacterial product that arises in the intestine, and its interaction with far distal tissues and organs via the induction of immune mediators. Dr. Rhonda Patrick was the keynote speaker for the Metabolic Health Summit, held May 5 – 8, 2022, in Santa Barbara, California. Her presentation described the role that intestinal permeability and bacterial products play in aging, inflammation, and chronic disease. Get the show notes at https://www.foundmyfitness.com/episod... 00:00:00 - Introduction by Dr. Dominic D'Agostino 00:03:12 - Intestinal permeability 00:05:20 - Atherosclerosis 00:10:57 - Brain 00:13:16 - Circulating LPS and behavior 00:16:13 - Toll-like receptors and inflammation 00:21:09 - Factors that affect intestinal permeability 00:27:19 - Alcohol 00:29:16 - Gluten 00:32:31 - Butyrate and dietary fiber 00:34:58 - Dietary fat 00:39:31 - Biomarkers for intestinal permeability 00:40:21 - Omega-3 fatty acids 00:47:12 - Questions & Answers LEARN MORE: Coinciding with this release, you can now find a variety of deep resources on the FoundMyFitness website for all of the topics covered in this episode. Learn about the blood-brain barrier: https://www.foundmyfitness.com/topics... Learn about intestinal permeability: https://www.foundmyfitness.com/topics... Learn about toll-like receptors: https://www.foundmyfitness.com/topics... Learn about cerebral small vessel disease: https://www.foundmyfitness.com/topics... SUPPORT THE CHANNEL: Many of these magnificent resources exist directly as a result of our premium members. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of this great resource at https://www.foundmyfitness.com/premium . ABOUT THE METABOLIC HEALTH SUMMIT: Over several immersive days, MHS brings together the world’s top experts to present the latest science on a variety of topics related to metabolic health including nutrition, fasting, longevity, cancer, mental health, diabetes, optimizing human performance, the gut microbiome, and more. Learn more about their CME and CPE credited event at https://www.metabolichealthsummit.com . #obesity #endotoxemia #leakygut Chapters Introduction by Dr. Dominic D'Agostino 0:00 Intestinal permeability 3:12 Atherosclerosis 5:20 Brain 10:57 Circulating LPS and behavior 13:16 Toll-like receptors and inflammation 16:13 100 Comments rongmaw lin Add a comment... FoundMyFitness Pinned by FoundMyFitness FoundMyFitness 1 day ago (edited) All of the topics covered in today's presentation is available as a deep article on our website. Please make sure to check these resources out. Blood-brain barrier: https://www.foundmyfitness.com/topics/blood-brain-barrier Intestinal permeability: https://www.foundmyfitness.com/topics/intestinal-permeability Toll-like receptors: https://www.foundmyfitness.com/topics/toll-like-receptors Cerebral small vessel disease: https://www.foundmyfitness.com/topics/small-vessel-disease BECOME A MEMBER: Many of these magnificent resources exist directly as a result of our premium members. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of this great resource at https://www.foundmyfitness.com/premium . CHAPTERS: 00:00:00 - Introduction by Dr. Dominic D'Agostino 00:03:12 - Intestinal permeability 00:05:20 - Atherosclerosis 00:10:57 - Brain 00:13:16 - Circulating LPS and behavior 00:16:13 - Toll-like receptors and inflammation 00:21:09 - Factors that affect intestinal permeability 00:27:19 - Alcohol 00:29:16 - Gluten 00:32:31 - Butyrate and dietary fiber 00:34:58 - Dietary fat 00:39:31 - Biomarkers for intestinal permeability 00:40:21 - Omega-3 fatty acids 00:47:12 - Questions & Answers 21 Nydia Marrero Nydia Marrero 1 day ago Dr. Patrick is able to explain complicated scientific terms into one easy to understand. Thank You Dr. Patrick!!! 29 FoundMyFitness Gef Ginn Gef Ginn 1 day ago Great presentation ! I'm going to go back and listen to this one or two more times to make sure I soaked in all the gems of information I am wanting to remember and pass on to family and friends. 14 FoundMyFitness Miss Dashwood Miss Dashwood 6 hours ago So thankful for Rhonda and the important information she generously shares with us. Just one thing here - BARLEY contains gluten as does wheat, rye, kamut and spelt to name some commonly consumed grains. 3 Little Voice Little Voice 3 hours ago Thank you for sharing this recording of your live talk. It is so useful and means those of us unable to afford the costs of the Metabolic Health Summit can still learn from your wise words Brandon Giarusso Brandon Giarusso 1 day ago Im a covid Long Hauler with extreme high elevations of pro inflammatory cytokines including TNFa and IL-6. Wonder how much leaky gut plays into why I became a long hauler, and many of my symptoms. We also have very high levels of intermediate monocytes, could this be because they are phagocytozing LPS? 4 Marco Cee Marco Cee 23 hours ago Great video. We're so lucky to have easy access to such information at the click of a button these days 👍 5 FoundMyFitness Stephen N Stephen N 1 day ago This was terrific! Thank you Rhonda. 4 FoundMyFitness Tom Solitario Tom Solitario 8 hours ago The graphics greatly enhance the presentation. Thank you, Rhonda for adding them to your session. Also, the timeline for the presentation is very useful as your presentations are quite long. It would help all of us viewers if you added recommendations for adjusting life styles, diets, etc. for healthy living and sited in the timeline where those are. Tim Ferris often adds "show notes" after his podcasts to them to enhance the viewer's/listener's experience...Just a thought. Again, thank you. 2 E I E I 1 day ago Congratulation for the presentation, it is very professional! I also loved the Q&A section! Thank you for spreading these valuable infos 2 FoundMyFitness Jimm Jimm 19 hours ago There’s not many Dr’s like you out there. I have been following you since the video sulforaphane. Thank you for sharing your knowledge! NN NN 3 hours ago Thank you for all you do Dr. Patrick. Would you be able to do a video on the latest studies of mRNA vaccines and if it is showing to be able to cross the blood brain barrier. Also, what the latest information is on mRNA and if it is changing the DNA in the liver. ctigernews ctigernews 1 day ago (edited) So does this mean taking fish oil capsules 15 minutes after a meal reduces IP because the Omega 3 destroys the LPS peak at one hour? (or something 😅)? 5 sabin cioflec sabin cioflec 1 day ago 1. I bet LPS is different depending on gut bacteria, also you can add fiber to a diet and increase inflammation in that person -> some people with good gut bacteria will do fine with a ton of sat fat diet and other people will feel shitty. 2. Omega 3s should be taken from pickled fish , i bet any type of heat will destroy the omega 3s that we need. Same goes to animal meat/fat ( especially bone marrow and brain ) but that's a different story. Also AGE's will go through the roof when you cook meat, i'm pretty sure we need to eat it as raw as possible, just like most choline remains in a very soft cooked egg. 3. I think Dr. Zsofia Clemens is the leading entity when it comes to intestinal permeability and she is the leader of the "group" that uses peg400, she would answer a lot of the questions. 5 Ray Kinney Ray Kinney 1 day ago I think it important to try to assess relative nutrient values of particular foods by trying to determine prehistoric evolutionary biologic conditions we have been adapted to over countless thousands of years. Was the beef we ate 30 thousand years ago grass fed, more than grain fed? Seasonality of grazing most likely had cattle eating grass much more than any grain, so we would very likely be better adapted to the complex systems of eating/metabolism of wild grass-eating beef cattle. And since protein poisoning seems to be an important part of how we evolved, prehistoric hunting populations were likely adapted to eating fat beef whenever possible rather than always just eating the leanest cuts of meat. And, eating lots of root carbs as well, to balance the 'rabbit starvation' effects that they had learned needed such balance to keep them healthiest. IMHO 3 Kevin Ryan Kevin Ryan 23 hours ago (edited) You are the best, my life has improved because of your first visit on Rogans show!! My blood pressure has improved significantly and every thing else from being pre diabetic to lowering my bad cholesterols and raising my good cholesterols.. Thank you Rhonda 3 Timothy Hennigan Timothy Hennigan 1 day ago Good stuff Dr. Rhonda Patrick. 2 FoundMyFitness Pedro Lavigne Pedro Lavigne 23 hours ago Dr Paul Mason gave a succinct and clear presentation on this topic a few years back 1 emlau12 emlau12 18 hours ago A typically bloody excellent talk. Thanks. Christopher Smith Christopher Smith 1 day ago Thank you Dr. Patrick! 2 FoundMyFitness Monica Broniecki Monica Broniecki 9 hours ago Hoping that you see this question: when LPS has crossed the blood brain barrier and caused damage, is the damage caused likely to be permanent? In other words, will I have to live with the sins of the past? Talia Talia 4 hours ago This is an excellent LPS summary for various organs How To Sand A Floor How To Sand A Floor 21 hours ago Absolute gold, as usual jayalanlife jayalanlife 18 hours ago 1st great eye opener and well elucidated. I will stick flax for O3 because I don't like tablets and not sure if thay have been heat treated, in Japan they consume fish raw but again I'm not accustomed to raw. Your thoughts would be greatfully received. Cheers Alan youtubeweber youtubeweber 22 hours ago Hey, Dr. Patrick. Thanks to you, I’ve had big green smoothies 6 days a week for the past 5 years. Rhonda M Rhonda M 1 day ago The hard to find answer is what kind of OTC Omega 3 is actually effective?? I've been taking Krill and recently learned that isn't going to meet the minimum bar but I also hear that most OTC Omega 3 supplements offered on the market are either rancid or contain dosages which aren't effective. If one can't get a doctor's prescription for Omega 3, then where should we be investing our dollars? 3 Dana Pearson Dana Pearson 1 day ago Glad Rhonda's BACK! 8 FoundMyFitness Jan Jileček Jan Jileček 1 day ago Great talk. The last question is cut off though, what was it about? steve myers steve myers 1 day ago trailer is the best promo you can do - well done! 3 FoundMyFitness S K S K 1 day ago I have leaky gut issues. I will be tuned:) thanks 4 FoundMyFitness JRR31984 JRR31984 1 day ago Very GOOD video title, "intestinal permeability"-- like meiosis and mitosis. (a big duh) 7 Yama Nosu Yama Nosu 1 day ago I'm genuinely so excited to see this haha. I have like 3 alarms setto remind me 😂 4 FoundMyFitness Dmitry Agafonov Dmitry Agafonov 1 day ago Excellent! 1 FoundMyFitness uelude uelude 5 hours ago Rhonda.. Do you think it's unwise to have high levels of glutathione / antioxidants daily? Increasingly there are warnings due to pushing the balance to far towards antioxidants to the detriment of vital oxidant related signaling. The 'youtube space' is crying out for some wisdom on this underrepresented and misunderstood balance. SioLazer SioLazer 17 hours ago Dr. D'Agostino introducing you is a way cool power stance. Dig it! FoundMyFitness Alex McMahon Alex McMahon 16 hours ago Does ALA have the same impact on gut health as DHA and/or EPA in terms of permeability or do they all behave differently? Tom Bunker Tom Bunker 6 hours ago No mention that Omega 3's DHA and EPA at least, induce the cellular housecleaning of Autophagy. That may be the main reason for the health benefits of Omega 3's. Taking Fish Oil every day may not be the optimum way to health. I would suggest that Omega 3 consumption weekly may be better. Boden Boden 18 hours ago Well done Tom Solitario Tom Solitario 8 hours ago Rhonda highlights that sardines are a good source of fatty acids. But are canned sardines, which, I'm guessing, are highly processed, are they a good source of Omega fatty acids or has all the nutrition been "leached" from the fish in processing them for canning? 1 Scottish Fold Mocha Scottish Fold Mocha 1 day ago 33:22 - sources of fermentable fiber - you forgot to include my favorite - acacia fiber 1 Ketones Not Glucose Ketones Not Glucose 14 hours ago The problem is there's way too much farm raised fish out on the market. We need politicians that actually act to get this bacteria induced frankenfish off the market... And it's a global problem! 2 Martin Tippins Martin Tippins 14 hours ago (edited) Mixture of science and fashionable nutrition advice. But there ARE many papers about LPS btw. Its a hot topic. sCiphre sCiphre 10 hours ago Who is the mansplainer at 49:00? Very interested in his research on LPS, he had some interesting points. 1 Mel Mel 20 hours ago I just need a daily eating plan for the year. 1 Boden Boden 19 hours ago About the heavy cream, consider casine and its exorphins. alice coppers alice coppers 1 day ago As a person over 65 who has been a vegan and used alternative medicine on my life I do not have gray hair and I do not wear glasses. I am in better shape than most 30-year-old as I do martial arts and compete with a lot younger people. When you look at different societies and their mortality rates America’s falling while Asian countries their life spans are increasing. If you want quality of life diet is the key otherwise you can spend your lifetime visiting doctor offices. 1 mark veen mark veen 1 day ago (edited) (Super)Centenarians having very low markers of inflammation and even bloodsugar. It might be good to note that this has little or nothing to do with lifestyle and diet. Seems to be almost entirely genetic. Simply said: just better (DNA)repair and bulletproof immune system carries you to extreme longevity. Whole grains lower inflammation. Sure, if there isn't any glyphosate there. US? Choose your grains wisely. Here in europe where I live almost everyone eats grains without any problem. Alot of oats, barley, rye, spelt and not so much wheat. Higher Omega3 and Vit.D is again lower inflammation and autoimmune issues. Translates to better immune system, health and longevity. 5 Ron Laduke Ron Laduke 1 day ago I would love to see Dr Rhonda interview with Dr Gundry? 3 EatVeganHelpEarth EatVeganHelpEarth 21 hours ago (edited) Interesting talk. One thing you claim "low Omega-3 intake from seafood" as a significant cause of preventable death, while intimating that plant sources are not adequate sources. But your citation doesn't deal with the question of sources of Omega-3's and their effect on mortality. Rather, after the 1st use of the word Omega-3, the 2009 research paper puts the word "seafood" in parenthesis - kind of like using the word protein and putting the word meat after. Pedro Lavigne Pedro Lavigne 23 hours ago Consistent with the findings published by ICMNI a while back Sheik Daddy Sheik Daddy 1 hour ago (edited) There are studies to show that when fat and carbohydrates are combined there is an increased fat storage over when they are isolated. Insulin opens up the key that allows the fat to go in. I say this because ask yourself what foods in nature exist that have close to or equal proportions of fat and carbohydrates and protein? The answer is milk something that is designed for growing bodies and that a lot of people become intolerant to the sugar of overtime. There is no food in nature other than this that intended to for us to be combining these macro nutrients. you can find protein and carbs you can find protein and fat you cannot find carbs and fat and you can definitely not find all three in close to equal proportions outside of milk. Cashews and pistachios would be the closest and they are not close to being equal in ratio. As much as omnivore is logical we don't understand the interactions that the stomach has to deal with at the same that it's never had to deal with before in the history of humans. Add to that all of the fake junk food on top of it. Greg Johnson Greg Johnson 3 hours ago The presentation refers to Pendyala S. Walker JM. Holt PR A high-fat diet is associated with endotoxemia that originates from the gut. Gastroenterology. 2012;142(5):1100-1101 e2. doi l 0.1053/j gastro 2012.01.034. I searched for this and could not find out what they considered a Western Diet (High-Fat.) This was likely a diet high in inflammatory seed oils which would trigger those results. It might not be high fat that is the culprit, but the type of fat. Bobby Ocampo Bobby Ocampo 20 hours ago What happens if you remove grains from your diet? Chris Bent Chris Bent 1 day ago (edited) Ok, I just have to ask this... why is there such a killer anime-cyberpunk intro with smoothly animated machinery to this talk? I love it but I legitimately don't understand. Xensonar Xensonar 1 day ago I love hearing all the different ways I'm gonna be f**ked when I'm old. 10 Patrick Nugent Patrick Nugent 21 hours ago Follow the science Rhonda , not your confirmation bias. Whole grains are an excellent foods, fats not so good outside of their fibre matrix. Ketogenic diets elitist unsustainable and a disaster for the planet. Love your work on the whole . 2 Rui-9-CS Rui-9-CS 20 hours ago nice! Linda Ripp Linda Ripp 4 hours ago Thanks Scottish Fold Mocha Scottish Fold Mocha 1 day ago (edited) 52:42 - young gentleman? Is that a hint that the lady who is asking question is NOT young? Bobby Ocampo Bobby Ocampo 20 hours ago What happens if carnivore Diet? Macaron Afterparty Macaron Afterparty 15 hours ago 49:02 Is this "mansplaining"? lol Fluffy Hamster Fluffy Hamster 6 hours ago Keto Num Nuts.. ImTryingHere ImTryingHere 9 hours ago 49:25 tommy wood in the house B B64 B B64 21 hours ago 2:29

Fasting, Longevity, Autophagy & mTOR Inhibitors - Peter Attia, MD 404,541 views Premiered Jun 6, 2019

Fasting, Longevity, Autophagy & mTOR Inhibitors - Peter Attia, MD 404,541 viewsPremiered Jun 6, 2019 High Intensity Health 543K subscribers Peter Attia, MD, is one of the leading thought leaders in the field of enhancing lifespan through dietary changes, intermittent fasting (IF) and exercise. In this show, we discuss a range of exciting topics with a focus on enhancing autophagy and inhibiting mTOR through nutrition, fasting and pharmacology. ➢ Subscribe to Peter's Channel: https://www.youtube.com/channel/UCXGA... ➢Check out Peter's Amazing Podcast https://podcasts.apple.com/us/podcast... ➢Links to full show notes and studies: http://bit.ly/2QWLAAY -----------------------------------------Lets Connect-------------------------------------- ➢Audio Podcast: https://podcasts.apple.com/us/podcast... ➢ Instagram https://www.instagram.com/metabolic_mike ➢ Facebook https://www.facebook.com/MikeMutzelMS -------------------------------------- VIDEO GEAR & TOOLS----------------------------------------------- Gravity Blanket (use code HIH10 to save): http://shrsl.com/1o7wi A Metabolism Book Should Have:https://amzn.to/2jUiAh5 Best iPhone Stabilizer: https://amzn.to/2IuCFFw Vlog Cam Canon M50: https://amzn.to/2jRBTEd Sony Vlog Cam: https://amzn.to/2DhRV4j Interview Cam C100 ii: https://amzn.to/2EC5NE8 Best Lens Ever: https://amzn.to/2IJ9WZC Vlog lens: Canon EF-S 17-55mm f/2.8 IS: https://amzn.to/2IGlfSo Good Audio: Rode VMPRPLUS Videomic Pro: https://amzn.to/2v9W9cm -------------------------------------- Key Timestamps---------------------------------- Links to full show notes and studies: http://bit.ly/2QWLAAY 0:00 intro 04:14: Endurance athletics and lactate testing 06:10: Doping in endurance sports: why cycling is not really clean 08:22 Training adaptations and MCT transporters 10:34 The cori cycle in the liver turns lactate back into glucose. The brain can use lactate directly as a fuel. 11:43 Longevity has no clinical trial. 13:42 Two interventions that offer longevity in animal models: fasting and Rapamycin. Both downregulate mTOR and both support autophagy. 15:35 Rapamycin is used for immune suppression in patients who have had organ transplants. 25:02 Dr. Attia does not use telomere’s as a marker of ageing since so many other things can influence it. 26:48 We need a blood test that measures some sort of signature autophagy. 28:46 Fasting is the single most potent tool in our toolbox of nutrition. 32:53 There are 50 different fasting regimens called intermittent fasting and we have no way to rank them or customize them to people’s goals. 34:20 Every gram of glycogen moves with 3 to 4 grams of water. The water goes into the plasma first and then out again as your body tries to conserve sodium. 41:58 Methionine levels drop quickly in fasting. Leucine levels remain about the same even 7 days in. 43:54 Research found that T4 and T3 decreased in the first 3 days of a fast, but leveled out after that. 45:35 In a fasted state, your body upregulates the enzyme that converts T4 into reverse T3. 50:33 At the end of a fast, Dr. Attia has very low testosterone, but experiences little to no symptoms or reduction in strength. 55:53 The literature on NAD is confusing. 01:00:24 Fasting is the single most important tool for treating metabolic disease and should be a part of any protocol. 01:04:09 People who do not do well on a ketogenic diet may have issues with the enzymes that regulate ketogenesis. 01:07:14 Metformin has a possible use as a longevity agent. 01:11:59 Berberine and Metformin go after the same pathway and probably should not be taken together. 01:21:05 Dr. Attia’s morning routine: He gets up early, listens to a lesson and meditates using apps 10% Happier or Waking Up. Chapters intro 0:00 Training adaptations and MCT transporters 8:22 The cori cycle in the liver turns lactate back into glucose. The brain can use lactate directly as a fuel. 10:34 Longevity has no clinical trial. 11:43 Two interventions that offer longevity in animal models: fasting and Rapamycin. Both downregulate mTOR and both support autophagy. 13:42 Rapamycin is used for immune suppression in patients who have had organ transplants. 15:35 637 Comments rongmaw lin Add a comment... Texas Casey Pinned by High Intensity Health Texas Casey 2 years ago (edited) Thank you so much - I appreciate the information from Dr Attia. Mike , you little brainiac! You are so humble, attentive and respectful during your interviews - the best guy!!!! You never let your ego get in the way by trying to impress by what you know and I am a follower of yours - you are amazing! God bless my friend. 209 High Intensity Health rachelmaechel rachelmaechel 2 years ago Love Dr. Attia. He's intelligent and full of knowledge and he's not afraid to say when something is not fully understood. No BS from him. Great interview, great discussions. Thank you Mike. xoxo 104 High Intensity Health Siim Land Siim Land 2 years ago Coming up with a device that measures autophagy in real time at home will be a game changer 279 High Intensity Health Optimize with Science Optimize with Science 2 years ago I love how structured and precise Peter approaches literally everything. 32 High Intensity Health JoAnna Secor JoAnna Secor 2 years ago (edited) I found this very interesting. I had a full thyroid panel (including RT3) as well as sex hormones (including Testosterone) after a 24hour fast and had the same results as Dr. Attia. (Not sure about the specific ratios though) This resulted in my Doc putting me on desiccated thyroid meds and told me I needed testosterone. Mind you, I did have many symptoms related to hypothyroidism. I’m interested to find out what my levels might be without fasting. 10 Fat Lives Matter Fat Lives Matter 1 year ago The benefits of fasting even 18-6, OMAD & Multi-Day Fasting are endless. In my 50's and feel better now than I ever have. Strongly recommend fasting for anyone. 7 Final Start Fitness Final Start Fitness 2 years ago (edited) I love the part where he is talking about the significance of 3 days of fasting on autophagy and glucose regulation as well as the thyroid discussion..So insightful!! 16 O Der O Der 2 years ago Mike, you are doing us such a great service by giving a platform to amazing professionals and people like Dr. Attia, Dr. Berry and the many other advocates of fasting and healthy lifestyles. Thank you so much for all of your work, consideration and professionalism. You are great at understanding, explaining and most of all listening to your guests. Have a wonderful weekend! 6 High Intensity Health shgfe3ay shgfe3ay 2 years ago Yesss TWO GREAT TITANS! This is goldust. If they taught this in schools instead of what the healthcare and food industry teach, then we’d be FAR better off! 79 High Intensity Health D Mummert D Mummert 2 years ago I can't say this enough, thank you. Your videos have helped me immensely. I'm 10lbs lighter and getting healthier every day. 8 Jesus Lozano Jesus Lozano 2 years ago 30 minutes in, and this is good stuff so far. Thank you, Mike! And thank you as well, Peter! 5 High Intensity Health 147DegreesWest 147DegreesWest 2 years ago One of your best podcasts! You were relaxed and the convo flowed. You should do more of these style interviews 11 High Intensity Health Radnally Radnally 2 years ago (edited) Great work. Thanks. I've seen other glucose testing during fasting that were similar to his experience. Getting and maintaining 50 to 60 after 48 hours. And keytones in the mid 5s as well. 3 High Intensity Health james Bond james Bond 2 years ago Very Educational and were lucky these researchers take time to discuss these concepts and protocol with us. I will forward this to all my medical friends. thank you guys 11 High Intensity Health Rog Rog 1 year ago Mike, I continue to watch your older videos and I’ve said it before and I’ll say it again. You are one of the best interviewer I’ve watched/listened too. Truly a beautiful art form that allows the speaker to get their information out in a way that we can follow. Thank You! 1 T D T D 2 years ago (edited) So glad Mike got Peter to talk. I've followed Peter for several years and agree with him on everything and learn so much every time he talks... 5 Rich Fisher Rich Fisher 1 year ago Great conversation with Peter, made me subscribe. I fast 3 Sundays a month and a 48 hour on the last weekend. Seems like maybe I need to incorporate a 72 hour fast. Knowing when autophagy kicks in would be an amazing tool to utilize. Ironmanix Ironmanix 1 year ago (edited) Thank you Dr. Attia for the information as always! This is one of the best disucssions I've watched on fasting. Annnnn Annnnn 2 years ago another great interview Mike, just wondering, I'm two days in on a 3 day fast and my heart rate has increased 10 beats and systolic blood measure has dropped 20 down to 100 over 67. What is happening? 8 High Intensity Health Patti C Patti C 2 years ago What an informative video, as all of yours are. Really appreciated your interview with Peter Attia!! Thank you so much! 1 busysuperhuman - Sara Pugh busysuperhuman - Sara Pugh 2 years ago Wonderful interview and guest, Mike. Not been on your channel for a bit but so happy for you that you are over 204k subs, you deserve it 1 Paul Cross Paul Cross 2 years ago This Podcast was fantastic. And listening to your Podcast consistently and other Podcasts in this space for over a year now allowed me to hang (80% maybe) with the rapid pace of today's Subject matter and I am so proud of that. But certainly planning on listening several more times during my walks to get the most out of this episode. For me Podcasts like yours are uplifting and motivational. Love the content - Thank you.. 2 Just look at the Flowers Just look at the Flowers 1 year ago So many people out there thinking they know it all and talking B.S, so good to hear someone who knows so much but honestly says there is so much more that no one know's yet. Love that he's his ongoing experiment and we get the feedback on his results. 3 SwinginSweetHeart SwinginSweetHeart 1 year ago Wow, I really enjoyed this interview. I am not sure who your targeted audience is however keep in mind, I am a nurse with a bachlors degree and had to look up some terms to make sure I followed everything you guys said. Awesome though loved the knowledge upgrade. I do have a question. I am a night nurse. How do I regulate my sleep :-) 1 RTC1655 RTC1655 2 years ago I'm on a 22-2 IF since a couple of years. It's been a life changing experience for me. Is this the best possible dietary lifestyle? Probably not but so far it's more than good enough. I've lost weight, more than 12 kg, but the testosterone boost is what I'm after. Training hard at the end of a IF cycle is simply a mind blowing experience. 2 High Intensity Health clipsTL clipsTL 2 years ago Hi you mentioned you do 1 day fast per week and 5 days each quarter. During the non-fasting days, how many hours do you allocate for your eating window? Thanks for this channel! 1 Claudia Wang Claudia Wang 2 years ago Gosh this podcast is GOLD. Thank you so much! I have a benign tumour in my liver and a few other health hurdles and am hoping a Ketogenic diet and IF will help reverse and heal it and then some. God bless you and your channel and all the beautiful guests you have. Can’t get enough of the knowledge bombs being dropped! 😂🙏😩🏋️‍♀️💪 3 brian warner brian warner 1 year ago Thanks for the great information!! I have a question; I have done 5 long fasts(5-7days each)this year, actually "fast mimicking diets following Valter Longo's macronutrient formula. I usually eat "keto",consuming 30-50carbs/day.While I recognize low protein is key, following Longo's formula on carbs doubles my carb consumption and , in turn, reduces my level of ketosis. Any thoughts or recommendations would be greatly appreciated. Keep up the great work! Myles Drake Myles Drake 2 years ago Mike I have a question for you. If someone fasted for a prolonged period of time (let's say 3 days) before doing a PRP session, would the higher concentration of endogenous stem cells from the fast aid in the PRP treatment? Could this be like a very low cost stem cell therapy alternative? Thank you so much! Myles 4 Tommy Huynh t_wrex_mtb Tommy Huynh t_wrex_mtb 2 years ago This is a great video, you guys really break it down scientifically, I just know that it works. I have been doing Intermittent fasting for 22 months. The first month I was eating twice a day in a small window but I have been eating only One Meal A Day (OMAD) for the past 21 months. I feel amazing, there are times on special occasions that I eat a 2nd meal but it only happens 2-3 times a month. I lost all of my weight (30 pounds) in the first 90 days and I have kept it off ever since. I started OMAD to loss fat but now that I hit my goal weight I continue to do OMAD for autophagy. It was interesting to hear what changes you guys have felt during fasting. I also get cold easily now then ever before. Some other changes are; I dont require as much sleep (6 vs 8hrs) my hair and nails grow much faster. My skin is slightly more dry (which I didnt really noticed until you said it) way more energy, way more focused and obviously Im in the best shape of my life. 17 High Intensity Health Dr. M. Vincent Curley Dr. M. Vincent Curley 2 years ago Many of my older patients have been unsuccessful in fasting, even in the short term. My guess is because their liver hasn't used gluconeogenesis in so long that its like using a back-up rusty generator that hasn't been serviced since before the cold war. 20 Illegal Notes Illegal Notes 2 years ago This is by far the best advise I've ever heard, thank you man 1 A C A C 2 years ago Thank you for this video. I’ve just started intermittent fasting and I’m trying to find more information on fasting with hypothyroid conditions. Here you talk briefly about T3 and T4 but I’m still not sure if fasting is good for me. I was diagnosed with Hashimoto’s when I was 7 and have been taking meds for 31 years. If there are any references to this that anyone has come across, I would love to know about them. It seems that around 19 hours of fasting I start to get light headed and very weak and am forced to eat something, I’m not sure if this is a result of my thyroid. Thanks. 2 High Intensity Health Da Lin Da Lin 2 years ago This was fantastic! Great interview. Thank you for the information! 1 High Intensity Health J Man J Man 1 year ago So far I've intermittent fasted for 3 weeks and fasted for 3 days of 2 of those weeks. 164lbs to 152lbs. Pretty crazy you guys, workout on the first day hard and light exercise like walking when fast. When intermittent fasting work out as much as you can, say goodbye to fat within weeks. More or less depending on your motivation Fasting Rules Fasting Rules 2 years ago (edited) You know this has gotta be good if it's Mike Mutzel interviewing thee Peter Attia. Hitting the like button even before I listen. 13 High Intensity Health James King James King 2 years ago Some of the stuff about thyroid and testosterone changes during fasts and also with weight loss was very interesting to what I have experienced and wondered why. 2 Sandi & G Sandi & G 2 years ago Rewatched this video a few times, such a great interview! 3 Mazinable71 Mazinable71 2 years ago Hi Mike! Greetings from Poland! Your materials, as usual, are great. Concise, wise, helpful. Could you please try to find someone who's in curing neuropathy with fast/autophagy? I've been trying to spot such person or to find some materials (research, data), but there is so little on that topic. Neuropathy is a serious problem of about 15% people suffering from diabetes. I've diverted diabetes T2 after 12 years and all of he symptoms are gone but peripherial neuropathy is still a major issue for me. And for so many others as well. Anyway, thanks for your effort so far! 2 High Intensity Health F Cast13 F Cast13 1 year ago A Tour de Force by Peter! In a casual conversation in an indiscrete kitchen? It made me cry. I love these topics but I am always will be a child among giants. Peter Attia is a genius in his ability to explain these complex topics in a personal way. Never disappointed! misterbobdobalina misterbobdobalina 2 years ago I think these conversations are interesting. I’m reminded that fasting has probably been expounded on by the wisest and most prolific people from time but still we can’t exhaust the topic. With respect to Peter Attia I believe the most effective dissertation has been more simply put by less lettered folk. 1 High Intensity Health Nathanael Kitchen Nathanael Kitchen 2 years ago Another amazing one Mike!! Keep it up. 2 garzascreek garzascreek 2 years ago I like how Peter Attia uses himself as a laboratory. He is such a wealth of practical knowledge. And Mike Mutzel is the best interviewer on YouTube. 5 Joshua Schow Joshua Schow 2 years ago Been waiting for Attia from you for a long time. So good! Thanks, Mike! 23 High Intensity Health Diego KRUGER Diego KRUGER 1 year ago A real conversation! Sadly, too many podcasts talk about talking with very little substance for our time invested. They appear to be in some mutual exercise of ego-stroking and promotion of their brands. They could learn from a conversation like this one. Tao Glassworks Tao Glassworks 1 year ago I love that he said that!! "There is nothing in Biology that is universal "🤩🤩🤩 QUERTY USER QUERTY USER 8 months ago You're so knowledgeable Mike. Learn a lot. Lone Wolf Anon Lone Wolf Anon 2 years ago Awesome 👏😎

Longevity, Senescence, Autophagy, mTOR Inhibition + More w/ Jeff Grimm 55,640 views Mar 25, 2020

BIOLOUNGE Longevity, Senescence, Autophagy, mTOR Inhibition + More w/ Jeff Grimm 55,640 viewsMar 25, 2020 High Intensity Health 543K subscribers Jeff discusses science-based ways to get rid of these senescent (old) cells—which may help both longevity and immunity. ➢ This episode is sponsored by Redmond Real Salt! Salt hand-harvested and microplastic free. Get the best salt in the world: https://bit.ly/real-salt ➢Connect with Jeff: https://bioloungepdx.com ➢Episode Show Notes & Research: https://bit.ly/senolytic-therapies-1 ➢Related Episode about Telomeres w/ Jeff: https://youtu.be/L3irS84U8rs --------------Sleep & Camera Tools You NEED!----------------------- Best Sleep Mask: http://bit.ly/2AIVbDV Blue Blocking Glasses: http://bit.ly/blueblox Gravity Blanket (use code HIH10 to save): http://bit.ly/cooling-gravity-blanket A Metabolism Book Should Have:https://amzn.to/2jUiAh5 Best Mouth Tape (Nexcare): https://amzn.to/31qJayh Red Headlamp (wear this at night around your house): https://amzn.to/2YzMGtw Breath Right Strips: https://amzn.to/31t5VSl Best iPhone Stabilizer: https://amzn.to/2IuCFFw Sony Vlog Cam: https://amzn.to/2DhRV4j My Interview Camera C100 ii: https://amzn.to/2EC5NE8 Vlog lens: Canon EF-S 17-55mm f/2.8 IS: https://amzn.to/2IGlfSo Good Audio: Rode VMPRPLUS Videomic Pro: https://amzn.to/2v9W9cm -----------------------------------------Show Notes-------------------------------------- 05:07 Sauna research indicates that when your heartrate is about 140, you are in the right temperature for cardiovascular benefit and releasing heat shock proteins. 08:19 With age comes senescent cell accumulation; cells that do not perform their essential functions, do not self-destruct and effect surrounding cells. 09:06 If you can get rid of senescent cells in your body, you get a 10 or 20% life extension. 10:50 A senescent cell intervention study caused most senescent cells to go away. 15:30 Autophagy has a senolytic effect. 16:32 If there is low autophagy activation in the body, lifespan is shorter. 19:10 DNA expresses itself differently when autophagy is upregulated. 20:30 Stem cell activation increases in the refeeding stage after a fasted state. 22:15 In mice, it takes at least a 2-day water fast to induce autophagy. 26:30 If there are a lot of nutrients in the environment, cells grow and procreate. In cancer, this is not a good thing. 27:10 If there are no nutrients in the environment, cells get good at recycling/scavenging and hunkers down to protect its DNA so it cannot break. 28:44 The antioxidant theory of ageing has been debunked. 30:33 A constant feeding state stimulates cancer growth through upregulation of growth hormone IGF1 and insulin. 33:36 Testing can show where patients are on the longevity path. 36:24 Overconsuming protein by over 20 to 30% in your diet, you get increased IGF-1. 37:39 A good IGF-1 level, based on Blue Zone cultures, is around 150 for mid-life. 42:14 If you restrict methionine in mice, they live longer. 46:05 AMPK can be activated through Metformin, berberine or the Chinese herb jiaogulan. 48:02 Rapamycin works well to suppress TOR in animal models. 51:22 NAD is the rocket fuel needed for sirtuins to do their job to protect DNA. Fasting increases NAD. 56:17 We don’t know if taking NAD increases lifespan or if it lowers cardio-metabolic risk. 01:00:35 Your DNA gets methylated as you age. When DNA is methylated, certain sections of DNA code are turned off and your cell does not do what it is supposed to do. 01:02:50 CPG sections of DNA are highly correlated with the ageing process, if they are methylated. It is a better marker for ageing than telomeres. 01:03:59 When your DNA at the CPG sites is methylated, it is irrevocable. 01:04:40 Ageing tests, from Elysium and myDNAge examine CPG sites. 01:08:35 The DNA clock was reversed by 2 ½ years. 01:13:07 Paradoxically, studies show that increases in growth hormone leads to longevity benefits, yet high growth hormone is disaster from a longevity standpoint. 01:17:40 DHEA for men is probably safe with a recommended dosage of 25 to 50 ml. DHEA has a positive effect upon the immune system and helps with certain markers of cardiovascular function in men. 01:21:37 Low levels of DHEA increase your risk of all cause mortality. 01:23:12 Fasting mimicking, to a higher extent than fasting, increases mucosal stem cell activity. 203 Comments rongmaw lin Add a comment... Luann Rouff Luann Rouff 2 years ago If a drug is strong enough to help you, it's strong enough to hurt you. I just want to be healthy now. For me that means no sugar, no alcohol, no dairy, no wheat, plus intermittent fasting. Also, eat with pleasure and a grateful heart. Spend time in nature. Hope 2020 is a year of "good vision" for the planet and all its inhabitants after recent events. 99 Roustabout4fun Roustabout4fun 2 years ago (edited) This is going to be good! Complicated but his articulation for us is a gift ..... Wonderful channel that gives us the gift of motivation to clean up our maintenance. Nice ! 41 Elizabeth Booth Elizabeth Booth 2 years ago Jeff, many of us are so thankful for Mike. Most doctors treat chronic fatigue, etc as non diseases. One becomes exhausted asking for help. Best regards, Elizabeth 7 Davina Davina 2 years ago This channel is pure gold! Thank you for sharing this very interesting discussion. 8 Mindhive Mindhive 2 years ago Does anyone else feel this primal surge of energy and intuition when they go on a long fast? For me it's always felt like I'm reconnecting with my ancestral roots. 4 Bernadette Becher Bernadette Becher 2 years ago Such a great conversation and so much information here. Thank you for passing on this knowledge in the podcast. 3 V4D2 V4D2 2 years ago the last video you did with Jeff is actually one of my favorites of yours, so i had high expectations for this one. i’m glad to say that it didn’t disappoint ;) . So kudos to you both. Many thanks! i’m currently 115lbs (177cm tall) and i want to return to my previous 150..160lbs. It is pretty hard to gain muscle mass doing intermittent fasting, in deed, so i am considering going from 3 meals, to 4 . that would mean i would have to forgo the 12hour no-food window.. Judging from what you guys talked about, scientific data/confirmation on the benefits of that 12hour window are still pretty scarce.. I didn’t know that. i thought it had been scientifically shown that it really has benefits. A 2 to 3 days fasting once a month might be a good idea, then, i feel. Still..i’m currently 4.5% fat..so fasting is very tasking on my muscle tissues.. what do you reckon ? thanks again Mike, cheers from Portugal 10 High Intensity Health Gonzalo Corts Gonzalo Corts 2 years ago You always have such interesting interviews Mike!!! Thanks for putting out these videos!!!!! 🙏🏽 3 party38 party38 2 years ago Thank you for another great informative episode! Recently watched Dr. Mercola where he said that we should be cautious with fasting due to toxins that are being released from fat storage where they accumulate into blood stream. What are your thoughts on this? Thank you 4 gatobava gatobava 2 years ago Wow! Great talk and great guest. Covered a lot of topics and explained well for the lay person. 8 High Intensity Health Lili Robin Lili Robin 2 years ago (edited) I learn so much from your channel. You are the best at the interviews!!!! You are so smart but let the others talk. Just excellent! 2 Pepper Pepper 2 years ago Awesome show! Notes taken throughout. Thank you for the knowledge! Bill kimura Bill kimura 6 months ago Great interview Mike. Keep doing what you do. 👍 OliverMarcellBjerregaard OliverMarcellBjerregaard 2 years ago Awesome info as always! And Mike, my man, looks like you've been putting on some solid muscle mass! marygraceful marygraceful 2 years ago These guys are brilliant wow. Thank you for sharing such rich knowledge 2 FEVERED DREAMS FEVERED DREAMS 2 years ago Such a revelation, thank you so much for your dedication! uelude uelude 2 years ago (edited) Amazing video, Jeff is a wonderful and intelligent guy. I'd really like to see Ted Naiman's response to Jeff regarding protein, would love to see that chat. Also importantly I'm very curious to know how Jeff, as a thinner guy, approaches the subject of gaining muscle or simply working out, or perhaps he prefers not to thereby having a younger body and mind for longer? It's really ultra key for keto dieters who are losing muscle mass. There are many recommendations of 2g of protein per kg per day.. but how to fit that in a 4 hour feeding window? The body would have trouble processing 150g+ of protein so muscle gain is extremely difficult. And using a long window we hear time and again over-stimulates mTOR Do you know of anyone willing to put forward a strategy to balance Protein, mTOR, and muscle growth (or at least prevent muscle wasting) while not overstimulating mTOR / IGF1 which we hear all the time is the big bad move in the longevity game. For example: Goals-wise I'm keto for inflammation reduction (it works) and fast for autophagy and I feel great afterwards which leads me to conclude it's also anti-inflammatory. But I've lost my 10kg of fat and I'm losing muscle.. following Naiman's philosophy I should just eat tons of protein.. which is exactly what I had planned until this vid which yet again drove home hard the IGF1 message extremely eloquently. If feeding window (or the 20 hour fast out of it) is the solution then is there a way to consume 150g in 4 hours without the body just saying "too much protein to process properly let's convert some into glucose and dump a load". I was thinking 3 day fast (starting keto adapted it's quite intense) at the end of each month to help cleanse the mTOR mess from too much protein during the month. Maybe a 2 day fast mid month also. Possibly choose a 'big work out' day once a week where I forgo the feed window rule. Seems quite a 'pulsatile' compromise.. although the 150g a day in a small feed window is the biggest question.. is this wise? Logistically seems possible but idk how the body would process it (apparently body can process 60g after workout.. maybe start: Take 30g protein with keto lunch, then 2h30 later 15g EAA then work out and 60g whey isolate immediately after, then 45g (eg: 150g meat) in a meal after an hour, close window. ) Is this wise or am I messing with IGF-1 and mTOR too much? Trouble is in a nutshell: I'm 37 and getting old.. keto is perfect to reduce inflammation but I'm losing muscle mass, a solution is high protein a la Naiman but INF-1 and mTOR are so important especially hearing Jeff reiterate and further embue some very wise mTOR lore. Final idea for discussion: Feed window on alternate days (eg: 4hr window except 3 training days a week where there is 8hr window where you could have 150g protein starting 30g in the morning workout after 2 hrs then 60g, then 2 hrs 30g 2hrs 30g.. Then next day, the alternate, back to 4 hr window with lower protein (BUT HOW MUCH can you take on a rest day in 4 hours on keto?) We don't hear so much about a 2 day oscillation detailed in interviews, occasionally though. This stuff is not for bodybuilding per se, it's so fasters and keto community can stay healthy and avoid muscle loss.. it happens! Any thoughts? Or links greatly appreciated. :) 4 Brynn Major Brynn Major 2 years ago Wow thank you for this!! Also, the detail in the description box🙌🏽 9 High Intensity Health Sarah Sandoval Sarah Sandoval 2 years ago SO GOOD- gonna watch it a third time- lots of great info to absorb! 👍🔥👍 omnipenguinify omnipenguinify 2 years ago (edited) Could you talk about criticisms of the blue zone study? The main one being that it cherry picks these zones. There are other long lived populations that don't eat 10% protein. Hong Kong being an example here. And the other criticism was that some of the zones weren't really plant-based. Okinawa being the most egregious example. Another thing, Americans don't eat 30% protein. We eat 10-16% protein. 6 Ricardo Wilkins Ricardo Wilkins 2 years ago One of the most effective ways to restore or eliminate senescent cells is by replenishing our bodies with stabilized ROS/RNS. They have several roles in the body, one being cellular messengers and our bodies built-in method to detect repair or replace damaged cells. Um Nachtet Um Nachtet 2 years ago The longevity vs performance discussion is essential Jay Gonzalez Jay Gonzalez 2 years ago Luv the intro man. I appreciate your work. Thank you for your time. 🙂 8 High Intensity Health Aiyang Tao Aiyang Tao 2 years ago Great talk ,thanks . Could you please discuss C 60? It seems better than Vitamin C. Emery Cole Emery Cole 6 months ago Kirkland has some good insight concerning sentient cell recycling. I’m ketogenic & mostly Carnivor, OMD, 48h/wk Fast & KAATSU-BFR newbie. Great health results but way to many “IF’s” about pills-supplements etc. I take NAC, D3 a few times a wk but feel best just by eating lots of Real Salt! N=1 keep searching. Glen Meyer Glen Meyer 2 years ago One of the best videos you have released...! 35 High Intensity Health Azaliia Persits Azaliia Persits 2 years ago I loved it so much! Thank you ! 1 Sid Michael Sid Michael 1 year ago (edited) Life changing lessons right here. Raw Bacon Raw Bacon 2 years ago Hour and a Half, looks like I got something to keep me company while I do a little woodworking today. 3 Eviya Eviya 2 years ago I dont need a cake. This video is the 5-Michelin-star treat! 12 Boon Doggle Boon Doggle 2 years ago When they say that a certain percentage of your diet should be made up of protein, are they presuming that you’re eating three meals a day in a standard eating pattern? What if you only eat one meal that day? Is it really a matter of the percentage or the amount, and if it’s the amount, what amount would they say is ideal? 4 Angela A Stanton PhD Angela A Stanton PhD 2 years ago Awesome! truly enjoyed this chat. 1 El Jake El Jake 3 months ago I think the focus on mtor and igf-1 is from a place of not looking at the body as a system. I enjoyed this guy’s perspective and I appreciate that he stressed that they are still important. Valter Longo annoys me greatly. Fasting is obviously superior to fmd and he focusing on processes that are simply not being utilized by the body correctly. You shouldn’t want to down regulate mtor or reduce igf-1, the goal should be to direct it to metabolically active tissue! Get in a lift in the am or anytime before breaking a fast and you will do just that! Same with metformin, it’s just doing exactly what your body does after exercise. To me it’s simple, lift before eating and walk after. Personally the lifting part is easy, the walking I neglect, but I think the lifting is more important in the context of growth factor sequestration. Enjoyed the discussion as always! Thank you, Mike! 1 Steven Noren Steven Noren 2 years ago A place I want to go at 63 years old trying to reverse age and improve health I've managed to reverse quite a bit but a lifetime commitment is what it takes. 4 Jean Carlo Him Jean Carlo Him 2 years ago How can you measure the levels of disfunctional cells? TALENA AN TALENA AN 2 years ago I haven't seen you do any talks on Ozone. Ozone has helped me so much! I have tried every "healthy" thing from A-Z and nothing has helped me more than ozone. I would love for you to do an interview or talk about it. 1 Ida Ida 2 years ago Jeff says the word fruit and Mike has to say fish. Mike, what’s wrong with your brain? Fruit is good. Sandro Itsme Sandro Itsme 2 years ago Regarding vitamin C, it looks like you guys are ignoring the fact that a primate the size of a human would make 10 grams of vitamin C and we make none. I'm 71 and haven't had a cold or the flu for over 40 years. All that time I've taken at least 6 grams daily, but often much more. Also, no one ever guesses me to be over 50, so I'm not about to shun C! 20 Chad Aitken Chad Aitken 2 years ago Good stuff Jeff, thx Mike. Renewed interest with DNa and DHEA. Jeff made it sound like DNa methylation is permanent? Is it like breaking a segment of an erector set? How does smoking do that? We can’t repair it? Thx. Purple Gh0st Purple Gh0st 2 years ago Mike, What are the benefits of taking metformin if you are not prescribed it by a medical doctor? 2 Final Start Fitness Final Start Fitness 2 years ago (edited) I remember the Telemere talk.. that one was so good!! 2 Robert Flury Robert Flury 10 months ago I couldn't quite make out the two drugs they use in the anti senescence trials he mentioned around 10:50 . One was an anti chemo drug and the other sounded like a supplement. Josh K Josh K 6 months ago This one didn't get enough views. Great interview Jody Jackson Jody Jackson 2 years ago So. NIce to see two people sitting together closer than 6 feet apart talking 🤗 4 Keith Haken Keith Haken 6 months ago Very good material. Except for that billion year old single cell (apparently with its own brain) floating in the ocean and evolving into people. 🤣 John Hughes John Hughes 2 years ago This is fantastic. How can you test your DHEA? Truly Truly 2 years ago What does this mean for Carnivore Eaters? I've always been fascinated and perplexed about the implications of Carnivore Eating as it relates to Longevity and mTOR activation. 4 john bassett john bassett 2 years ago Why is it always about taking a supplement unless you have decreased availability through poor absorption as you age? 1 Green Deane Green Deane 2 years ago If avoiding cold baths means I will die young then I will die young. I loathe being cold. Conversely I love long, hot saunas. 5 Thomas Jepsen Thomas Jepsen 2 years ago Amazing video! 1 Stephen Hazel Stephen Hazel 2 years ago ok Mike - are YOU gonna try that? 3 days of 1000mg Quercetin + 100mg Dasatinib? If that kills off a lotta lame cells, that sounds pretty cool! I guess I'd need a prescription for Dasatinib. I watched this a 2nd time. startin 50mg DHEA each morning with my bp med cuz i'm 54 and it can only help i think. ordered myDNAge :) Did my longest fast about a month ago - 3.5 days. Gonna try it quarterly with that FMD stuff. Stephen Hazel Stephen Hazel 2 years ago thankk you! best video everrr. I learned a lot. will watch a second time tomorrow. Sid Michael Sid Michael 1 year ago Can fasting kill senescence cells? 1 A.D. ROSS A.D. ROSS 2 years ago I LOVE REAL Salt! I get their Seasoned Salt also. The Only Jamie Bourgeois The Only Jamie Bourgeois 2 years ago Watching this while on the third day of a water fast. 3 Jay Leon Jay Leon 2 years ago Does d ribose boost nad naturally? Any studies on specifically? I've searched online but thus far I haven't found one. Actual Nad seems to be very expensive. Brian Richard Brian Richard 10 months ago I intend to live forever. So far so good. - Steven Wright 2 Marcus Glading Marcus Glading 2 years ago mike are you worried about taking dhea and the link to bad outcomes for steroid use with covid patients william zebrowski william zebrowski 2 years ago with regard to animal protein, IGF-1 and people in hong kong eat a pound and a half of meat a day , i think Dr Saladino would disagree with you strongly with all due respect , interesting info anyway 1 Madina Vadache Madina Vadache 2 years ago (edited) We just scratching the surface of untagging science.its the next level when you are general health is good👍🏻👍🏻 7 High Intensity Health gaurd3 gaurd3 2 years ago (edited) I paused Tiger King for this. There is so much foolishness you can watch before it rubs off. lol Great talk Diana Valdez Diana Valdez 2 years ago Love this 👍👍👍 John Osborne John Osborne 2 years ago Got super nerdy!!!! LOVE IT!!!!!!!! guitargeeknwa guitargeeknwa 1 year ago He mentions blue zones consuming only 10% protein, but these 'blue zones' have been debunked, not only by researchers but by people who live or have lived in these areas. How long do you think you are gonna live, anyway? If you only eat 10% of calories as protein, you're likely gonna be weak in old age. I don't think 10% protein facilitates 'strongevity'. Otherwise, a wonderful interview and discussion. Naima B Naima B 2 years ago Quercetin is zinc ionophore, which help immune system what do you think about these 2 combinations? 1 GMW GMW 1 year ago I was in Portland 12 years ago. Liked it a lot. Too bad it's been all downhill since this interview was done. Downtown Portland is a no go zone now isn't it? Hank Nelson Hank Nelson 2 years ago Maybe Autophagy is not a sprint, but a marathon. Slowdown and go faster. Rebounding From Narcissistic Abuse Rebounding From Narcissistic Abuse 2 years ago Only watched 1 min and I am hooked 2 Kid Vinie Kid Vinie 2 years ago He is one interesting guy! Rambling Rose Rambling Rose 2 years ago (edited) Great interviewer! Fascinating Guest! Wonderful topic! Stop Eating, People! It's that simple!!!! 2 Teresa Moews Teresa Moews 2 years ago I'm looking for anti cancer in all this longevity data. I'm a two time cancer patient in remission and want to stay there. I eat mostly whole foods and plant based. I just learned about NAD+ and how it grows cancer... Can you give me some direction? Sophal27 Sophal27 2 years ago (edited) NAD, GH, DHEA, testosterone, metformine, why suplements when you can have similar or even better results just by eating well, intermittent fasting and weight lifting, and for much cheaper. 5 Pink Supremacy Pink Supremacy 2 years ago I had super low levels of DHEA and I recognize all of the symptoms of no energy etc. But I cant get a hold of it in fucking socialist Sweden. Do you know where I can get it??? I'm 32 btw. Naima B Naima B 2 years ago Hi Mike Love your channel Suer Erin is zinc ionophore is 1 g per d sufficient Alex Berukoff Alex Berukoff 1 year ago (edited) AWESOME VIDEO,, HAVE YOU ANY THOUGHTS ON FISETIN 1 Sid Michael Sid Michael 1 year ago What is DHEA for? Indigo Love Indigo Love 2 years ago Thanks so much. Great information, but he spoke way too fast. Blessings 1 SuperResistant SuperResistant 2 years ago Excellent Para Bellum Para Bellum 2 years ago When you want to wear a blazer but they turned up the heat ;) 5 Van Lee Van Lee 2 years ago Does any one have a link for the topical rapamycin? Susan Beever Susan Beever 5 months ago No mention of oxytocin and stopping senescence. Marky Mark Marky Mark 2 years ago 4 to 5 days for autophagy 👀👀 yikes, please make him stop. . . Lol. . . I'm running with the idea that as I am physically active allows me to activate it much quicker 1 Gold Hunter Gold Hunter 11 months ago Let's see...............with carbon 60, AKG, rapamycin, eeg and spirmidine then maybe I can still have my chocolate milkshakes. emmas816 emmas816 2 years ago 1:35 -Redmon Real Salt contains crashed glass, every bite of food salted with this salt makes this horrible sound on my teeth like I am eating sand. Not going buy it ever again. 2 tbmcnation tbmcnation 9 months ago salt consumption shortens telomeres M M 7 months ago You guys are "Truth Seekers." Sid Michael Sid Michael 1 year ago 51:10 is the final answer. Teb Tengri Teb Tengri 2 years ago So what was the chemotherapy drug he hinted at around