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Matt Kaeberlein reflects on "David Sinclair’s Longevity Lie"

Matt Kaeberlein reflects on "David Sinclair’s Longevity Lie" Dr Matt Kaeberlein 14.1K subscribers Subscribed 546 Share Thanks Clip Save 13,827 views Sep 5, 2024 The Optispan Podcast with Matt Kaeberlein Subscribe to our channel: / @optispan Check out Scott Carney's channel: / @sgcarney Related episodes: The True Story of David Sinclair's Longevity Lie: • The True Story of David Sinclair's Lo... DON'T Take Resveratrol Until You Watch This Video: • DON'T Take Resveratrol Until You Watc... Scientists Debate How to Live Longer & Longevity Drugs: • Dr. Charles Brenner: How to Live Long... An introduction to the study of RAPAMYCIN: • An introduction to the study of RAPAM... In this episode, Matt and Nick react to investigative journalist and author Scott Carney's video describing what he calls "David Sinclair's longevity lie" in the context of David's longevity-focused entrepreneurial ventures. Matt shares his professional history with David, including his early interactions with David in Leonard Guarente's lab at the Massachusetts Institute of Technology (MIT) and scientific differences that emerged after Matt and colleagues were unable to reproduce a key result from David's work pertaining to resveratrol. Their discussion touches on some of David's scientific claims about age reversal, the role of institutions such as Harvard University in regulating scientific integrity, the potential for future interventions in healthspan and longevity, and the importance of separating personal feelings from scientific evaluation. David, currently a professor in Harvard Medical School's Department of Genetics at the Paul F. Glenn Center for Biology of Aging Research, is a prominent geroscience researcher whose lab focuses on age-related epigenetic change, cellular reprograming, longevity drug discovery, mitochondrial fitness, reproductive aging, neurodegenerative disease, and the human secretome. He has received awards including the National Institutes of Health Nathan Shock Award, the Merck Prize, and the Australian Medical Research Medal, and was elected to TIME's 2014 “100 Most Influential People in the World" list. David conducted postdoctoral research at MIT and obtained a PhD in Molecular Genetics at the University of New South Wales. 0:00 Introduction 6:12 The video begins 7:21 Claims of immortality 8:26 The consequences of making unsubstantiated claims 10:23 A logical fallacy 15:04 Some clarifications about SIR2 17:23 TED Talks + getting information from credible sources 19:15 Setting the record straight on sirtuins and lifespan 22:19 Reproducible work from David's lab 24:02 GlaxoSmithKline's decision 25:42 Conflating the resveratrol story with sirtuin biology 26:10 A "buddy system" of reviewing papers 30:57 Andrew Huberman and Peter Attia + bashing the scientific enterprise 33:20 Show us the data 37:25 Why hasn't Harvard taken action? 41:41 Not a totally fake space 44:34 Relationship with the FDA 50:04 Matt's resignation from the Academy for Health & Lifespan Research 54:14 Immortality vs tackling the biology of aging 56:13 Closing thoughts 58:55 Looking at the comments Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: / optispanpodcast Twitter: / optispan Twitter: / mkaeberlein Linkedin: / optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful! Chapters View all Explore the podcast 101 episodes The Optispan Podcast with Matt Kaeberlein Dr Matt Kaeberlein Podcasts Transcript Follow along using the transcript. Show transcript Dr Matt Kaeberlein 14.1K subscribers Videos About 122 Comments rongmaw lin Add a comment... Pinned by Dr Matt Kaeberlein @sgcarney 4 months ago (edited) Thanks for doing this reaction video. Looking forward to watching. It would have been great to have Matt in my video, but at least I can hear his reaction now. One thing that is tricky about reaction videos is that it's easy to make unsubstantiated conclusions when you pause the video to make a point that is answered in the following sentences. Not to belabor the point, but at 31:02 Matt says "Ok Scott, why don't you show me the publications records of Andrew Huberman and Peter Attia and we will see how much they have dominated the literature." YT's automod will probably remove the link if I post it here, but on my channel I did EXACTLY that when showing how Huberman used his position in Cell Reports Medicine to get Susanna Soberg's terrible research on BAT published. But you paused the video in a way that you came to a conclusion before seeing evidence. Which is basically what you are accusing me of throughout your reaction. I think this has a lot to do with the format. It might be better to watch the whole video first and then watch it again to add your reaction on the second play through. Flash edit: Throughout the video (54:07 for example) Matt suggests that when I say "the immortality grift" that I'm saying that Sinclair believes he's selling actual immortality, and you accuse me of not understanding the difference between immortality and longevity. What you fail to notice is that I'm saying a complete phrase "immortality grift" which is the type of scam that has been around for thousands of years and that Sinclair continues to sell with his various pills. Perhaps I was not clear enough on that point when I explained it in the intro as it does seem some commenters in my video made the same conclusion. The "immortality grift" is selling a thing that does not exist. This results in Matt misconstruing my words to make a straw man argument. 21 Reply 8 replies @keefeweekers5739 4 months ago Sinclair really showed what he is after his deal with the FDA. Thanks for other professors for exposing Sinclair's lies. 26 Reply @CraigHocker 4 months ago Thanks for the more sober discussion. Sinclair’s tendency to indulge in hype shouldn’t be countered with sensationalist journalism. This podcast was a good antidote. Thanks for deciding to post what had to be an uncomfortable show. Really it is worrying that other longevity scientists have stayed quiet about the product marketed for dogs. 27 Reply 2 replies @dannyhaynes6944 4 months ago (edited) This changed my mind on that Sinclair piece by Scott, which is hugely valuable to me. Please keep it up. 16 Reply @michelsamson3689 4 months ago Bravo, Matt! I have been following the more prominent people in the healthspan/aging space and you are by far the fairest and clear-headed proponent of this field. And by the way, I love dogs too. My oldest is going to be 16 yrs old this month and with the aid of rapamycin he is still doing quite well. Thanks again for this unbiased video. 6 Reply @Nick_Henri 4 months ago Glad you decided to air this and much appreciate your candid, transparent and very well informed perspective! 8 Reply 1 reply @ulric_official 4 months ago This reaction video is just outstanding, halfway through really enjoying it, wishing I could give it some more thumbs up. Lots of insight into “the industry” so to speak, great reactions to various BS😂, while coming from the perspective of someone who went into it fresh without any particular agenda 👏 👏 6 Reply @adjusted-bunny 4 months ago I am glad that episode aired. I have always gotten snake oil salesman vibes from D.S. 17 Reply @ulric_official 4 months ago This reaction video is gold, hopefully gets more views and more subscribers for the channel 🙏 7 Reply @jorgefunes5925 4 months ago I like your talks as they are impartial and without a hidden agenda as others 5 Reply @PinataOblongata 4 months ago Thanks for deciding to air this, I like the targets Scott is going after, the investigation adding to the picture of said targets, and I feel like his motivations are largely the right ones. I do agree his language and hyperbole needs to be cleaned up if he wants to be the bastion of truth-seeking and bringing-the-receipts that I think he wants to be. Seeing his discussion with Dr Mike the other day, it seems he also thinks about presenting things as if it was a court case, so it might be putting it in those terms could give him some pause for thought about the language used or how much research he does into a field that one of his targets operates in. I would like to see you guys in discussion, mostly because you could probably help each other in just presenting honest and "debunking" information online, which the world is sorely in need of atm. 4 Reply @FXDUBOIS 4 months ago It is to your credit that you had to say out loud what others knew but preferred to keep quiet... Keep the great work for the sake of science 👍 6 Reply @adam-356 4 months ago Thank you Matt, these kind of discussions and reactions are important for outsiders like me to form an own opinion. Please continue your data driven work and share your findings and opinions with the community. 2 Reply @yairkoren5268 4 months ago This was really great; some of the best value I got from a "Matt video". While the scientific work about resveratrol is probably great, the concept of the channel is to democratize such information for the more general public. This episode/format does exactly this and I'd be thrilled to see more of this kind of content. 2 Reply @popkinbobkin 4 months ago Well I guess David Sinclair is more of a businessman now than a scientist. And to get people interested and money flowing you need to become somewhat of a snake oil guy. He was actually the reason I personally learned about all this longevity stuff and I was excited exactly because of those claims that I now know are exagerated. Let's hope that his lies eventually don't kill the interest in the fied and disappoint people, and it's great we have people like Matt who can keep people's trust in the science. 8 Reply 1 reply @patriciasanchezwebb 1 month ago 7:21 You effectively say that you've never "heard" Sinclair talk of immortality. Yet just a few moments earlier you admit that you've never read Sinclair's book, Lifespan. In Lifespan, Sinclair certainly does imply that at some point people will be able to turn back that the aging clock over and over again. Sinclair doesn't say there will be a definite limit. 1 Reply @joparr4081 1 month ago (edited) What about Sinclair explaining that the reproduction of Resveratrol results being done incorrectly???!! You didnt read the addendum he published on how you are supposed to do it "every other day"...pulsing the supplement??? Therefore needs to be a cellular recovery period ... 1 Reply @KevinBrown-sz6eq 4 months ago Hi Matt, these reaction videos are valuable but it would be nice to get some more theory of aging type videos if you think your viewers would like it. For example I think it would be great to see you interview Josh Middledorf and contrast your opinions on the foundational causes of aging and on the accuracy of epigenetic clocks etc. I think you could also have a fantastic discussion with Mike Levin of Tuffs. Thanks Matt. 7 Reply @droprelease4820 4 months ago Thank you Matt, you explained in much nicer terms the gripes that I had with Scott's video! I wish his original video had more nuance in his discussion of David as a bad actor 1 Reply @virginiaferrarini 4 months ago Less hype and spin and more real stuff: this is what I'm looking for! Thanks 1 Reply Dr Matt Kaeberlein · 1 reply @fatboydim.7037 4 months ago Great informative podcast and interesting to see you take on this upload. Although I accept that Sinclair is a 'complex' character I have seen him post pictures regarding his father of late who looks in great condition and takes NAD boosters. My question revolves around partial cellular reprogramming, as which I understand Metro Biotech are advancing towards human clinical trial in 2025-possibly. Are you telling us that the science around this is also spurious ? because of Sinclair's involvement. Alot of people's quality of lives have been enhanced through his podcasts something that alot of detractors don't seem to be happy to focus upon. 2 Reply @gabymalembe 4 months ago I take a lot of the supplements that David Sinclair says work on mice though he always says he doesn’t know if they work on people, because maybe one of them actually works. If I were young I’d wait for some proof, but I’m not. 7 Reply @omvilla7469 4 months ago I hear you Matt... and other exceptics... we actually should never believe everything, they are all partial truths... anyways... my only issue here is: Why is Sinclair the only one who seems not to be getting older when compared to other scientists and Longevity advocates...?? I can mention so many that look so much older...🤔🤔 Some of Sinclair's science must be truth... 😮🤔🤔 4 Reply @jds02153 4 months ago top shelf 👍👍 2 Reply @Stemwellrestore 4 months ago (edited) Jeunesse Global sold Resveratrol in gel form and the results were incredible . Now i am confused because there are/were results, positive ones, when sick clients took the resveratrol satchets. 😮 1 Reply @Maple597 4 months ago Fabulous podcast! Keep it up! 1 Reply Dr Matt Kaeberlein · 1 reply @invertage 4 months ago I feel the same with the snake oil for dog lifespan. World record dog age record broken last year was 31 yrs old. Before that it was 29 years old. All natural diet seems to be the factors in these. Feeding a dog garbage kibble will shorten their life. Poor breeding practices by humans also a factor, they were all originally wolves. Cat record is currently 38 years. Give them a natural diet, plenty of exercise and a loving home, that's what they need. 2 Reply @briansykes2806 3 months ago I am very interested in this field, but it is hard for me to comment since I am very lacking in knowledge in genetics, etc. I certainly agree that research must be rigorously done and results should be expressed in moderate, not sensationalist terms. I like Matt Kaeberlein's general approach, although I have not seen a proper evaluation of his own research to date. Regarding funding, I have always thought this should come from another field entirely - not the pharmaceutical industry. 1 Reply @ZeitgeistHomer 4 months ago Excellent video. I love that you state the facts as they are without minimizing or exaggerating the truth. Now please, do an episode on Novos Labs and their supplements. They claim you are a consultant. Reply @jogeirmyklebust 4 months ago thank you for yet another great podcast! Reply @hoffmancapote 4 months ago Thanks for a great video. By the way glad you decided to publish this video. A decision will make Reply @33Crazydude 4 months ago Although we're not there yet, I believe that the only way we'll make a significant impact on both lifespan and healthspan is through the use of highly advanced AI. While there’s a lot of hype, if AI makes substantial progress in the next decade, it could unlock groundbreaking advancements in anti-aging science. However, the future remains highly uncertain. 1 Reply @diliu3460 4 months ago I just want to point out that the character "寿" on the background wall means longevity in Chinese, which I suppose was intended with good intentions. However, I have to say that Chinese people usually display these characters on walls at funerals, specifically in black and white. So that gives an unintended vibe here. lol. 1 Reply Dr Matt Kaeberlein · 1 reply @SilverFan21k 4 months ago Haha unexpected to see you cover this topic 😂 1 Reply @dude861 4 months ago Overall very, very ground based, smart and convincing explanations. Love your style and your perspective. Reply Dr Matt Kaeberlein · 1 reply @zombi3lif3 4 months ago Thank you for making this video. Reply @omvilla7469 4 months ago Or let's hope that despite trying to make a buck... or billions, some of those products actually work.... I do take some of them, and I am definitely much younger looking and energetic than many of my peers... 🤔🤔 oh well.... keep posting, this Longevity science is so interesting...👍👍 2 Reply @askingwhy123 4 months ago Biggest possible face turn: Sinalclair throws himself on Matt's mercy and redeems himself as a scientist. Imagine the clicks! 1 Reply @kurtrichardson-wv8yk 2 months ago Solid video Reply @jayalanlife5926 4 months ago Great episode guys, I would like to see an equivalent on exercise and diet Reply @Samucacamilo 4 months ago Matt please write a book. 1 Reply Dr Matt Kaeberlein · 1 reply @douglaswatt1582 4 months ago (edited) This sensationalist journalist piece by Scott Carney reminds me of a recent hit piece on Elon Musk. In between the black and the white are the shades of grey Of course that doesn't sell, esp. on YouTube, as well as spectacular and wild claims and counterclaims which people seem to gravitate towards unfortunately. So great to have Matt functioning as such a level-headed scientist and role model in a completely hype riddled space. I was always skeptical of David Sinclair the second he started making claims that he had found THE regulator of Aging. No such thing it's a whole network of factors obviously, operating in complex interaction, and it's pretty clear we don't know all the factors or understand all their interactions. 8 Reply @in2caffeine 4 months ago sinclair is pushing the public awareness over longevity research, and that is a good thing. he is imaginative and speculative, which is what is needed to really push the needle. 5 Reply 1 reply @bagus853 1 day ago The moment I first encountered his content about NMN on YouTube, my intuition immediately raised red flags. There's something about his presentation style and approach that feels inauthentic, particularly when discussing such an important scientific topic as NMN supplementation. I encourage others to carefully evaluate health-related content and trust their instincts when something doesn't feel right Reply @jonathonmills3563 4 months ago Scott is worse than the people he’s vilified. Hyperbole, exaggeration and nonsense 7 Reply 1 reply @TheBiffsterLife 4 months ago Having followed this closely, it appeared you didn’t go after Sinclair as hard as Charles Brenner did, while being in as good or better position to do so. Were you concerned about Sinclair’s influence? 1 Reply @houndofzoltan 4 months ago I'm a huge fan of Peter Attia and through him Matt Kaeberlein, but I've never really warmed to Andrew Huberman: I always feel he's faking it til he makes it. 1 Reply @JerzeyBird 4 months ago (edited) Glad that you gave perspective on Carney's video. I have some issues with Huberman, but I felt Carney's take down of him was straight up Page Six level. Also didn't think his POV on Attia was all that balanced. Despite their domination of the literature - hilarious. Too bad, because I loved his book on Wim Hof, but I hesitate to recommend it and no longer watch his channel. Carney and Sinclair have some tendencies in common. Eh, that soundtrack? lol. 3 Reply @Nelis1324 4 months ago I'm curious what this says about his current work. People keep giving him a platform as well. Reply @jaykraft9523 4 months ago (edited) You analyzed the wrong video, the Stanfield $720,000,000 Train Wreck video is much less sensational, lots less fluff, and has just the facts. It's just as damning of Sinclair without hyper-editorializing 4 Reply @robin-jewsbury 4 months ago I've never liked the phrase "no evidence for" when referring to something not happening in the future - lots of domain experts have failed spectacularly on this one. But in the case of "no evidence for longevity escape velocity", there clearly is and will be no evidence for 2 future events with the 2nd future event being long way in the future. I would not expect any evidence until near the 2nd event occurring - so we will reach longevity escape velocity without knowing it (no evidence), and won't know it until looking back at the 1st event in the past, from the 2nd event . So saying no evidence is sort of pointless/meaningless. 6 Reply @Halbared 4 months ago Bloke is using a jackanory voice. On a journo level, he's Stossel. 1 Reply @anthonyhopper7830 4 months ago At some point, you might think about creating a podcast that focuses on the bottlenecks in the geroscience field. You've mentioned some of them during your discussions/episodes. However, I don't think you've dedicated an episode to delineating them in detail. Your viewers who are non-scientists, like me, might find that information to be not only interesting but also useful (e.g., in helping us to decide where to donate/how to advocate for the field). PS. IMO only, "good old boy" networks might not exist in the life sciences, but they are definitely "a thing" in some humanities and social science fields (at least from my personal experiences). Reply @williamhenry3337 4 months ago Why does he have a million views and you only have a dozen views? Why do YOU have the TRUTH and others don't? 1 Reply @popkinbobkin 4 months ago Also would love to hear your opinion on current research of David Siclair. How legit is his epigenetic reprogramming stuff? What is the new "age reversing" molecule he is mentioning lately? There's a new video with him on youtube at the Aspen Institute, maybe Matt would be interested in commenting on it 3 Reply @houndofzoltan 4 months ago Given that Matt is here talking about this, why didn't he accept the offer to be interviewed? Wouldn't that have been a better time to point out these errors? 2 Reply 1 reply @houndofzoltan 4 months ago "So far, never paid off" is also poor grammar: should just be "haven't paid off so far" 1 Reply @allehelgen 4 months ago Could you do a vidéo on saunas ? 1 Reply @Halbared 4 months ago (edited) Trust tried to watch a few of his videos. Oooof. Something off about him. Chasing. 💨 Reminds me of the carpetbagger from Josey Wales. Reply @drewmccu258 4 months ago Pretty sure this is the guy from the Huberman hitpiece. Reply @stephenfaris6865 4 months ago I wonder if we could build a chemical model of a human and then apply AI to do complex what ifs? Reply @barzinlotfabadi 4 months ago We're not going to resolve this in the Octagon? I hear that's how it's done these days 😛 Reply @ananiadoesgaming8808 4 months ago You’re so obsessed with Dr. Sinclair Leave him alone 2 Reply 1 reply @portalminer8813 4 months ago As they say, there's two sides to every story. We've just heard one side. 1 Reply @Amun92 4 months ago Oops Galaxo and Harvard! 1 Reply @GAURAV_Feb 2 months ago First of all thanks for making this reaction video.. really helps to hear directly from the horse’s mouth.. However, it just worries me that this is the just an example of the Rapamycin Gang vs Resveretrol-NMN gang arguing!! Peter Attia and Matt Kaemberlin are gung ho on Rapa so potentially they have a motive to be against other CR memdics !! Also it just confuses me that Peter Attia sings songs about one stuff and then realizes that it’s actually toxic.. happened with metformin!! And vice versa with ozempic where he initially was against it and now he’s in the maybe zone!! It would be the joke of the century if it turns out that Rapa is useless as well!! Reply 1 reply @bostaurus1 4 months ago Thanks but guys devoting 5 or 10 mins to some minor issue at 35 was a bit off topic. On whether going to each other podcasts is similar to Harvard not taking action Reply @AS-gx4qg 4 months ago Read David's book. He claimed immortality. Reply @PakistanIcecream000 4 months ago Good video content but its introduction music is a bit off-putting for my taste. Reply @anatoly60 4 months ago I don't understand this guy, why is he bad mouthing others !? Why not challenge David to a debate ? 1 Reply @PaulWolf-t2h 4 months ago Sinclair is a scammer. But you have to be careful about everyone working in this field. There is a tendency to exaggerate. Reply @bogrunberger 4 months ago I get that Matt comes at this as a scientist and I completely agree with his arguments. However most of what David Sinclair does is that he goes on podcasts and he addresses ordinary people who have no chance of evaluating what's complete BS and what's actually solid of what David says. That's why I think that for ordinary people it would be better to completely disregard David Sinclair because he's proven that he exagurates and sometimes even approaches lying, and for us ordinary people it's impossible to tell when we should listen and when we shouldn't. What Sinclair has done is extremely damaging to the whole scientific longevity field because most people just see that another snake oil salesman has proven that it's all BS. It will take years to recover from what Sinclair's done I think. 1 Reply @jamesstrom6991 3 months ago anyone mildly interested in health span pegged Sinclair for a grifter years ago. Reply @wmp3346 4 months ago Matt may have an ax to grind? 1 Reply 1 reply @adamspongB6F1 4 months ago Matt continues to equivocate between dismissing fraudulent claims that longevity escape velocity is empirically imminent—and rejecting radical life extension as the appropriate conceptual goal of aging research. He snidely rejects all “futurists” as purveyors of the arbitrary, and he fails to understand the epistemological validity and essential role of inductive prediction in scientific development. Matt is smearing everyone who advocates for conceptual and moral clarity about the real value of pursuing aging research, and he’s hiding behind the kind of dishonest, myopic-on-principle “healthspan” spins that most people who fear the social opprobrium and ridicule that waits for any explicit and principled advocate for life extension resort to. Put simply, this is no more logically valid than rejecting “curing cancer” as an appropriate medical goal, and then pointing to some straw man crackpot claiming he can cure cancer now with household products as proof that the idea as such is pseudoscience. Matt should know better than this. At best, this is logical confusion. At worst, it is moral cowardice of the sort that drives a great many aging researchers to adopt a public affect of self-righteously short-sighted scientific obscurantism. Hiding from the inductively-established possibility of radical life extension—in the name of superior scientific subtlety? This is moral cowardice, not scientific sophistication. 1 Reply @jonathonmills3563 4 months ago David Sinclair doesn’t sell NMN. 3 Reply 2 replies @davidderidder2667 4 months ago They are corrupt and not as nefarious? Come on Matt, make up your mind, you are sending mixed and conflicting messages. With an already pretty overstretched collective public attention span, this is not what I believe is what will really helps clarify. Reply

TOP 25 best movie directors of all time | Iconic movie directors | Famou...

TOP 25 best movie directors of all time | Iconic movie directors | Famous directors of today 3,924 views Jan 30, 2025 #hollywood #top10 #toplist TOP 25 best movie directors of all time | Iconic movie directors | Famous directors of today. 🎬 TOP 25 Greatest Movie Directors of All Time 🎥 Are you ready to discover the greatest directors of all time? In this video, we’re counting down the TOP 25 movie directors who have shaped the history of cinema with their incredible storytelling and visionary filmmaking. From iconic movie directors of the past to the best directors of today, this list is packed with film directors whose movies you absolutely need to watch. Whether you’re looking for the top 10 movie directors, the best directors of all time, or just wondering who is the GOAT director, we’ve got you covered. Featuring famous directors like Steven Spielberg, Martin Scorsese, Quentin Tarantino, and Christopher Nolan, this is the ultimate guide to the best movie directors of all-time. ✨ What You’ll Learn: Why these top film directors are celebrated across the world. The legendary movies that made them famous. How these greatest directors of all time changed the art of storytelling. 👉 Who’s Your Favorite Director? Do you agree with our list of top 10 favorite directors and top 20 directors of all time? Let us know in the comments which great director of all-time is your favorite, or if there’s someone you think deserves a spot on this list! 💡 Don’t Forget to Like & Subscribe! If you’re a fan of greatest film directors and love exploring the work of famous directors, give this video a thumbs up, subscribe, and hit the notification bell so you never miss our latest content. #TopMovieDirectors #BestDirectors #hollywood #toplist #movies #FilmDirectors #top10 Transcript Follow along using the transcript. Show transcript Transcript 0:00 welcome to top list where we celebrate 0:02 the best of 0:04 cinema today we're counting down the top 0:06 25 greatest movie directors of all time 0:10 Visionaries who redefined storytelling 0:12 shaped the film industry and gave us 0:15 Unforgettable cinematic masterpieces 0:18 from epic Blockbusters to groundbreaking 0:20 dramas these directors have left an 0:23 indelible mark on the world of film 0:26 before we dive into this incredible list 0:29 don't forget to like this video 0:31 subscribe to our Channel and hit the 0:33 notification Bell so you never miss our 0:35 exciting content if you're a true movie 0:38 lover you're in the right 0:40 place all right grab some popcorn and 0:44 get ready to explore the Legends who 0:45 brought your favorite films to life 0:48 let's start with number 0:51 25 25th Place Christopher 0:55 Nolan Christopher Nolan is celebrated 0:57 for his cerebral storytelling and ab to 1:00 blend art and commerce seamlessly known 1:03 for crafting immersive visually stunning 1:05 narratives his films often explore 1:08 themes of time identity and human 1:11 resilience with masterpieces like 1:13 Inception The Dark Knight trilogy 1:16 Interstellar and dun Kirk Nolan pushes 1:18 cinematic boundaries with practical 1:20 effects Innovative storytelling and 1:23 thought-provoking ideas he is a strong 1:25 advocate for shooting on film and IMAX 1:29 delivering an unparalleled viewing 1:31 experience his films are not only box 1:34 office hits but also critically 1:36 acclaimed solidifying his status as one 1:38 of the greatest directors of the modern 1:42 era 24th Place David 1:46 Fincher David Fincher is a perfectionist 1:49 known for his dark stylish and deeply 1:51 psychological thrillers his signature 1:54 precision and dedication to multiple 1:56 takes result in visually Immaculate 1:59 films with gripping narratives with 2:01 iconic movies like C7 in Fight Club 2:04 zodiac and The Social Network Fincher 2:06 delves into themes of obsession morality 2:09 and the human psyche his meticulous use 2:12 of lighting color pallets and digital 2:15 effects creates an intense atmospheric 2:18 experience Fincher's ability to balance 2:20 intricate plots with compelling 2:22 characters has earned him widespread 2:24 Acclaim as one of the most Innovative 2:27 storytellers in cinema 2:30 23rd Place Ridley Scott Ridley Scott is 2:34 a Visionary director known for his 2:36 stunning visual storytelling and ability 2:38 to excel across genres from redefining 2:42 Science Fiction with alien and Blade 2:44 Runner to Epic historical dramas Like 2:46 Gladiator and the last duel Scott's 2:49 films are A Feast for the senses his 2:52 attention to detail atmospheric World 2:54 building and dynamic narratives have 2:57 influenced countless filmmakers with a 3:00 career spanning decades Scott's 3:02 Innovative use of practical effects 3:04 production design and strong characters 3:07 has cemented his place as one of 3:09 Cinema's most enduring and versatile 3:13 directors 22nd Place Sydney 3:17 LT Sydney LT was a master of moral 3:20 complexity and social realism known for 3:23 creating character-driven dramas that 3:25 challenge audiences over his prolific 3:28 career he directed class like 12 Angry 3:31 Men Dog Day Afternoon Serpico and 3:34 network lt's films often grappled with 3:37 themes of Justice corruption and human 3:41 fallibility his ability to elicit 3:43 Powerhouse performances and craft 3:46 tension filled narratives made him a 3:48 favorite among actors and critics alike 3:51 a five-time Oscar nominee lamt left an 3:54 indelible mark on Hollywood with his 3:56 integrity and commitment to storytelling 4:00 21st Place Quenton 4:02 Tarantino Quenton Tarantino is a 4:05 trailblazer known for his unique blend 4:07 of sharp dialogue pop culture references 4:10 and nonlinear storytelling with cult 4:13 classics like Pulp Fiction Kill Bill in 4:16 glorious bastards and Once Upon a Time 4:18 in Hollywood Tarantino has redefined 4:21 film making with his audacious style his 4:24 love for Cinema shines through his 4:26 eclectic soundtracks stylized violence 4:29 and homages to various genres 4:31 Tarantino's films are celebrated for 4:33 their Unforgettable characters dark 4:35 humor and intricate plots making him one 4:38 of the most influential and original 4:40 voices in contemporary 4:43 Cinema 20th Place Roman 4:47 palansky Roman palansky is renowned for 4:50 his psychological thrillers and ability 4:52 to create tension filled atmospheres his 4:55 Works including Rosemary's Baby 4:57 Chinatown and The Pianist showcase his 5:00 Mastery of suspense character 5:02 development and emotional depth pansy's 5:05 storytelling often delves into themes of 5:08 paranoia power and moral ambiguity 5:12 despite personal controversies his 5:14 artistic achievements have earned him 5:16 numerous accolades including an Academy 5:19 Award for best director pansy's films 5:22 continue to Captivate audiences with 5:24 their haunting visuals intricate 5:26 narratives and Powerful performances 5:30 19th Place Tim 5:33 Burton Tim Burton is an iconic filmmaker 5:36 known for his Whimsical Gothic aesthetic 5:39 and quirky storytelling his films such 5:42 as Edward Scissor Hands The Nightmare 5:45 Before Christmas Beetlejuice and Batman 5:47 are celebrated for their distinct visual 5:50 style and heartfelt themes of belonging 5:52 and 5:53 individuality Burton's creative use of 5:56 maab imagery vibrant colors and 5:59 imaginative worlds has inspired 6:01 generations of filmmakers with a career 6:04 that blends mainstream success with 6:06 personal Artistry Burton remains a 6:09 beloved and influential figure in modern 6:13 Cinema 18th Place Charlie 6:17 Chaplan Charlie Chaplan is one of 6:19 Cinema's earliest and most enduring 6:21 Legends a pioneer of silent films whose 6:25 influence continues to shape 6:27 storytelling known for his loved 6:29 character the chaplain directed 6:32 and starred in Classics like City Lights 6:34 Modern Times And The Great Dictator 6:37 combining slapstick comedy with 6:39 heartfelt social commentary chaplain's 6:41 films address themes of poverty class 6:44 struggle and Humanity his genius as a 6:47 director writer composer and actor 6:50 established him as a Timeless figure in 6:52 film history whose Works transcend 6:55 language and 6:57 generations 17th Place 7:00 Akira 7:01 Kurosawa Akira Kurosawa is a Titan of 7:05 world Cinema celebrated for his epic 7:07 storytelling and Innovative film making 7:09 techniques with masterpieces like Seven 7:12 Samurai rashan and akiru kurosawa's 7:16 influence extends across both eastern 7:18 and western Cinema his pioneering use of 7:21 dynamic camera work striking visuals and 7:24 deep humanism elevated The Art of 7:27 Storytelling known for exploring themes 7:29 of Honor morality and human resilience 7:33 kurosawa's Works have inspired directors 7:35 such as George Lucas and Steven 7:37 Spielberg his legacy is a Cornerstone of 7:40 cinematic 7:43 Artistry 16th Place Peter 7:46 Jackson Peter Jackson is a Visionary 7:49 director who brought epic storytelling 7:51 to life with groundbreaking visual 7:54 effects and masterful 7:56 Direction best known for the Lord of the 7:58 Rings trilogy 8:00 Jackson's ability to create immersive 8:02 worlds and Unforgettable characters 8:04 redefined fantasy film making his other 8:07 works including The Hobbit trilogy and 8:09 King Kong showcase his passion for 8:12 storytelling on a grand scale Jackson's 8:15 Innovative use of Technology such as 8:17 motion capture and his dedication to 8:19 detail have earned him multiple Oscars 8:22 and a lasting Legacy in 8:25 cinema 15th Place John Ford 8:30 John Ford is a legendary filmmaker whose 8:33 work defined the Western genre and 8:35 elevated it to an art form with iconic 8:38 films like the Searchers stage coach and 8:41 The Man Who Shot Liberty Valance Ford 8:43 crafted stories that explored themes of 8:46 heroism community and the American 8:49 frontier his Mastery of visual 8:51 storytelling often showcasing expansive 8:54 Landscapes and intimate character 8:56 moments left an indelible mark on Cinema 9:00 a four-time Academy Award winner for 9:02 best director Ford's influence extends 9:04 far beyond Western's making him one of 9:07 the most respected directors of all 9:10 time 14th Place Joel Cohen Joel Cohen 9:16 often collaborating with his brother 9:17 Ethan is known for his Darkly comic and 9:19 genre defying films together they've 9:22 created modern Classics like Fargo No 9:25 Country for Old Men and the big Labowski 9:28 the Cohen film films are characterized 9:30 by sharp dialogue quirky characters and 9:33 a mix of absurdity and poignancy Joel's 9:36 directorial Vision seemlessly Blends 9:38 humor and tragedy exploring themes of 9:40 morality fate and human Folly their 9:44 unique storytelling style has earned 9:46 them critical Acclaim and a devoted 9:50 following 13th Place inar 9:54 Bergman ingar Bergman is a towering 9:57 figure in World Cinema celebrated for 10:00 his deeply philosophical and emotionally 10:02 complex films known for masterpieces 10:05 like the seventh seal wild strawberries 10:08 and Persona Bergman explored existential 10:11 themes of Faith death and The Human 10:14 Condition his intimate character studies 10:17 haunting imagery and Innovative use of 10:19 light and Shadow have influenced 10:22 countless 10:23 filmmakers bergman's ability to delve 10:25 into the depths of human psychology and 10:27 relationships makes his work Timeless 10:30 and universally resonant earning him a 10:32 place among the greatest directors in 10:35 history 12th Place David 10:39 lean David lean is a master of Epic film 10:43 making known for his grandiose yet 10:45 emotionally resonant films his legendary 10:48 Works include Lawrence of Arabia Dr 10:51 zivago and The Bridge on the River Quai 10:55 lean's meticulous attention to detail 10:57 sweeping cinematography and ability to 11:00 balance scale with character-driven 11:02 narratives set him apart his films often 11:05 explore themes of ambition conflict and 11:08 human endurance with multiple Academy 11:11 Awards and a lasting impact on the art 11:13 of film making lean's work continues to 11:16 inspire directors and Captivate 11:18 audiences 11:20 worldwide 11th Place Clint 11:24 Eastwood Clint Eastwood is a Hollywood 11:27 icon who transitioned from acting super 11:30 stardom to becoming one of Cinema's most 11:32 respected directors known for films like 11:35 Unforgiven million dooll baby Gran 11:38 Torino and American Sniper Eastwood's 11:41 directorial style is characterized by 11:43 emotional depth moral complexity and a 11:47 subtle yet powerful storytelling 11:49 approach his work often examines themes 11:52 of redemption Justice and resilience 11:55 with multiple Oscars and a career 11:57 spanning decades Eastwood ability to 12:00 balance raw emotion with compelling 12:02 narratives has solidified his legacy as 12:05 one of the greatest filmmakers of all 12:08 time 10th Place Milos 12:12 foran Milos foran was a brilliant 12:15 director known for his ability to bring 12:17 humanity and depth to his films his 12:19 acclaimed Works include One Flew Over 12:22 the Cuckoo's Nest Amadeus and the people 12:25 versus Larry Flint Foreman's 12:27 storytelling often explored themes of 12:29 individuality freedom and Rebellion 12:32 against Authority his unique perspective 12:35 shaped by his Czech Origins brought an 12:37 outsider's eye to American Cinema with 12:41 multiple Academy Awards Foreman's Legacy 12:44 as a master Storyteller continues to be 12:46 celebrated for its emotional resonance 12:49 and Universal 12:51 appeal Ninth Place James 12:55 Cameron James Cameron is a Visionary 12:57 director known for his groundbreaking 12:59 visual effects and ability to craft epic 13:03 Blockbusters from the Terminator and 13:05 aliens to Titanic and Avatar Cameron 13:08 consistently pushes the boundaries of 13:10 filmmaking technology his dedication to 13:13 detail and innovation has set new 13:15 standards for cinematic storytelling 13:17 Cameron's films often explore themes of 13:20 Love survival and human connection 13:22 against stunning backdrops with multiple 13:25 Oscars and record-breaking box office 13:28 successes he is a trailblazer whose work 13:30 redefines what's possible in 13:33 film eighth place Federico 13:37 felini Federico felini is a legendary 13:40 Italian filmmaker whose work Blends 13:43 surrealism emotional depth and striking 13:46 visual Artistry renowned for 13:49 masterpieces like lul Vita 8 and a half 13:52 and amarcord felini created dreamlike 13:55 worlds that explore the complexities of 13:58 human nature memory and Imagination his 14:01 Innovative storytelling and bold 14:03 unconventional style redefined cinematic 14:07 expression a four-time Academy Award 14:10 winner for best foreign language film 14:12 felin's influence extends far beyond 14:14 Italy inspiring generations of 14:16 filmmakers and cementing his place as 14:19 one of the greatest directors in film 14:23 history Seventh Place Billy 14:26 Wilder Billy Wilder was a Master 14:29 Storyteller whose films Blended sharp 14:31 wit emotional depth and Keen social 14:35 observation known for Classics like Some 14:38 Like It Hot Sunset Boulevard and the 14:40 apartment Wilder excelled in both comedy 14:43 and drama his scripts often laced with 14:46 biting humor and incisive dialogue 14:49 explored themes of ambition love and 14:53 morality Wilder's meticulous Direction 14:55 and ability to capture the human 14:57 experience earned him numerous accolades 15:00 including six Academy Awards his 15:03 influence on Modern film making remains 15:05 profound and 15:09 enduring sixth place Woody Allen Woody 15:13 Allen is a prolific director whose films 15:15 explore the complexities of love 15:18 relationships and The Human Condition 15:21 with iconic works like Annie Hall 15:23 Manhattan and Midnight in Paris Allen's 15:25 sharp wit and unique Voice have defined 15:28 his career his ability to blend humor 15:30 with introspection often set against the 15:33 backdrop of New York City has earned him 15:35 critical Acclaim and a dedicated 15:38 following known for his distinctive 15:40 storytelling style and memorable 15:42 characters Allen's impact on independent 15:45 cinema is 15:48 unparalleled fifth place Francis Ford 15:52 Copa Francis Ford Copa is one of 15:55 Cinema's greatest storytellers best 15:57 known for his epic Tales of power and 15:59 family his masterpieces include the 16:02 Godfather Trilogy and Apocalypse Now 16:05 films that redefined filmmaking with 16:07 their intricate characters stunning 16:09 visuals and deep exploration of human 16:12 ambition and morality cop's ability to 16:15 combine Grandeur with intimate 16:17 storytelling has earned him multiple 16:19 Academy Awards a key figure in the new 16:23 Hollywood movement his Visionary 16:25 approach and willingness to take risks 16:27 have made him an endur ing influence on 16:30 directors 16:32 worldwide fourth place Stanley 16:36 kubri Stanley kubri was a cinematic 16:39 perfectionist renowned for his 16:41 groundbreaking visual style and genre 16:43 defining films with Classics like 2001 A 16:47 Space Odyssey A Clockwork Orange The 16:50 Shining and Full Metal Jacket Kubrick 16:53 pushed the boundaries of Storytelling 16:54 and Technical Innovation his meticulous 16:57 attention to detail haunting imagery and 17:00 exploration of complex themes like human 17:03 nature and societal Decay set his work 17:06 apart Kubrick's films remain Timeless 17:09 masterpieces celebrated for their 17:12 intellectual depth artistic ambition and 17:15 ability to challenge 17:18 audiences third place Alfred 17:21 Hitchcock Alfred Hitchcock known as the 17:24 master of suspense revolutionized the 17:27 Thriller genre with his unparalleled 17:29 ability to build tension and Intrigue 17:32 iconic films like psycho rear window 17:35 vertigo and North by Northwest showcase 17:38 his Mastery of visual storytelling 17:40 Innovative camera techniques and 17:42 compelling narratives Hitchcock's use of 17:45 psychological themes unexpected twists 17:49 and charismatic characters made his work 17:51 both popular and critically acclaimed a 17:54 true pioneer of modern Cinema his 17:57 influence can be seen in countless 17:59 filmmakers and genres cementing his 18:02 legacy as one of History's Greatest 18:06 directors second place Martin 18:10 Scorsese Martin Scorsese is a living 18:13 legend whose films are celebrated for 18:15 their raw energy complex characters and 18:18 exploration of morality known for 18:21 Classics like Goodfellas Taxi Driver 18:24 Raging Bull and the Irishman scorsi 18:27 masterfully portrays theme of crime 18:29 Redemption and The Human Condition his 18:33 Dynamic storytelling Innovative 18:35 cinematography and collaborations with 18:38 iconic actors like Robert dairo and 18:40 Leonardo DiCaprio have earned him 18:42 critical Acclaim and numerous Awards a 18:46 passionate advocate for film 18:47 preservation scorsese's influence on 18:50 Cinema and dedication to the art form 18:52 are 18:54 unparalleled and in first place 18:57 is Steven 18:59 Spielberg Steven Spielberg is often 19:02 regarded as the greatest director of all 19:04 time combining technical Brilliance with 19:06 universal storytelling from Jaws and ET 19:10 to Schindler's List and Jurassic Park 19:12 Spielberg's films have captured the 19:14 hearts of audiences worldwide his 19:17 ability to create both Blockbuster 19:19 spectacles and deeply emotional dramas 19:22 showcases his incredible range 19:25 Spielberg's work often explores themes 19:27 of wonder resilience and Humanity making 19:31 him a master of connecting with viewers 19:33 on a profound level with countless 19:36 Awards and a career spanning decades 19:38 Spielberg's impact on Cinema is 19:43 unmatched and that's our list of the top 19:45 25 greatest movie directors of all time 19:49 from Timeless Classics to groundbreaking 19:52 modern masterpieces these Visionaries 19:54 have transformed the way we experience 19:57 Cinema whether you're a fan of Epic 19:59 storytelling intense drama or 20:02 mind-bending visuals there's no denying 20:05 the incredible Legacy these filmmakers 20:07 have left behind which director on this 20:10 list is your favorite or is there 20:12 someone you think we missed let us know 20:15 in the comments below we'd love to hear 20:17 your thoughts if you enjoyed this video 20:21 don't forget to hit the like button 20:23 subscribe to our Channel and turn on the 20:25 notification Bell so you never miss out 20:27 on our latest content 20:29 your support helps us bring more amazing 20:31 videos like this to life thanks for 20:34 watching and we'll see you in the next 20:35 one until then keep watching keep 20:38 exploring and keep celebrating the magic 20:41 of Cinema TOP LIST 21.1K subscribers Videos About 29 Comments rongmaw lin Add a comment... @reneescala7526 17 hours ago Michaelangelo Antonioni, Jean-Luc GODard, Jean Renoir, Fritz Lang, Yasujiro Ozu, Robert Bresson - Orson - Kenji Misoguchi 3 Reply @SagnikBakshi0325 11 hours ago Kurbrick , Kurosawa , Tarkovsky , Bergman & Ray are the 5 pillers of world cinema. Period! 1 Reply @SagnikBakshi0325 11 hours ago Excluding Satyajit Ray & Andrei Tarkovsky from a list of best filmmakers is an act of crime! You also missed some of all time legends : Michealangelo Antonio, Fritz Lang, Jean-Luc Godard, Kiyoshi Kurosawa, Bong Joon Ho, Park Chan Wook, Wang Kar Wai etc. 1 Reply @NevHomlb 1 day ago You missed Fred Zinneman Howard Hawks and Frankenheimer 3 Reply @stevendavis1940 1 day ago Another list. These lists are stupid and exist just as clickbait. 4 Reply @SagnikBakshi0325 11 hours ago Spielberg at top looks stupid TBVH! 1 Reply @moises_munoz 4 hours ago Nobody agree with this list, me neither but I agree the 25 directors are good and very important to the cinema Reply @sushovanbasu9864 1 day ago Did you miss Goddar, Truffet and Satyajit Ray??? Or did I??? 1 Reply @arcook1963 22 hours ago Important all these directors i don' t say no, but where is David Lynch, Jean Pierre Melville, Francois Truffaut, Yasuhiro Ozu, Elia Kazan, Orson Welles, Sam Peckinpah and Brian De Palma. And Spielberg in the first place;! And Cameron so high on the list; 1 Reply @ProBonoPublicoNY 18 hours ago It's amazing that your list does not include William Wyler who directed diametrically opposed masterpieces with brilliance - The Collector and Ben Hur. Reply @pramitpanja8866 1 day ago I respect all the directors here, but where is Satyajit Ray? Reply @jeanmarieboucherit7376 12 hours ago Where is Orson? Reply @jimriley3934 13 hours ago Not that good of a list. Modern bias left out Hawks, Stevens, Houston, Wellman, Capra, Walsh, Peckinpaugh, Altman among others. Also, I am sure Woody Allen would laugh at this being ranked above Bergman, Kurosawa and Fellini, who all should be in the top five. Reply @redjjj213 21 hours ago Frank Zappa Reply @michaelfischer9401 1 day ago D.W. Griffith? Other silent era directors? French New Wave? Neo-Realism? Your list is a little heavy on present day blockbuster directors and light on directors from pre-1970. Spielberg ahead of Kubrick and Scorsese is debatable. But thankfully, George Lucas didn't make the list. Reply @eduardolopezgarcia4178 1 day ago John huston and mankiewitch Reply @Entenluc 22 hours ago (edited) Mit 70-80% gehe ich mit. Aber Tarantino so weit hinten? Kein Denis Villeneuve, Guillermo del Toro, Terry Gilliam, Oliver Stone, Luc Besson, Danny Boyle, Robert Zemeckis, John Carpenter, Brian de Palma, David Lynch, John Hughes, Fritz Lang....... und zusammen mit Steven Spielberg der größte aller Zeiten George Lucas. Reply @sbigglesworth4282 13 hours ago Stephen Spielberg is number 1? Ahead of Charlie Chaplin and Alfred Hitchcock? Give me a damned break. Reply 1 reply @ekhamp1 18 hours ago no orson welles? Reply @JamieWilliams-rh8vl 23 hours ago Total BS. My favourite director here is Scorsese. However, Hitchcock inspired just sbout every director on this list. Scorsese himself stated as much in interviews. I'm not even sure Scorsese is a genius director. The continuity in his films is notoriously off. He does have a knack for getting excellent performances from his cast and the stories he weaves stay with you because they're moral tales without being preachy and as such are hugely appealing. Reply