David Sinclair: Living to 120 and beyond | ABC Conversations Podcast

David Sinclair OAM is an Australian biologist based at Harvard University who is leading scientific fight against the inevitability of aging. Dr Sinclair believes aging is a disease, and we can find a cure for it. In the process, his lab has cured blindness in mice and has created tiny little brains out of human stem cells, which look like “little flesh-coloured peas”. Further information | https://ab.co/Conversations Lifespan is published by HarperCollins Credits Richard Fidler, Presenter Carmel Rooney, Executive Producer Meggie Morris, Producer Broadcast 28 Feb 2022 #podcast #conversations Subscribe ✅ and tap the notification bell 🔔 to be delivered Australian stories every day: http://ab.co/ABCAus-subscribe Web: http://abc.net.au/ Facebook: http://facebook.com/abc Twitter: http://twitter.com/abcaustralia Instagram: http://instagram.com/abcaustralia _______________________________________ This is an official Australian Broadcasting Corporation YouTube channel. Contributions may be removed if they violate ABC's Online Conditions of Use http://www.abc.net.au/conditions.htm (Section 3). Key moments View all 51 Comments rongmaw lin Add a comment... malsherbeeny malsherbeeny 10 days ago You're building a real arc for humanity. Thank you Noah.. I mean David. I love your work, and you've truly become my life coach and mentor since I watched your videos on YouTube 6 months ago. May nature yield and bow to your clever mind. 5 Reply Jeff V Jeff V 2 weeks ago 👍👍Excellent interview. Thank you gentlemen. I wonder...... when it comes to speculating how many more years of life a certain generation may have as a result of current and future medical breakthroughs and improved lifestyles, could it be possible we're grossly UNDERESTIMATING those numbers? Said differently, perhaps the developments will progress at a much faster rate than most expect, causing humans who are currently in their 50's to potentially live to be 130+? Asking for a friend....... 1 Reply Tom U Tom U 12 days ago (edited) Good video. Others like aubrey de grey think we have a 50% chance to extend our lives by 1 additional year each year within 15 years. Once at that point, we should pretty much live indefinitely unless we get hit by a car or something like that. 5 Reply Donna Oliver Donna Oliver 2 weeks ago A question in regard to fasting or time restricted feeding. We are told for example we need 4700mg of potassium per day, that is just one of many recommendations to keep our body running efficiently. With time restricted feeding how do we make sure we meet those goals? Is it possible that our body doesn't actually run on a 24 hour clock and we don't need this daily? Or does digestion itself dictate our 'daily' nutritional requirements. I'm confused, any comments? 4 Reply 3 replies Jeremy W Variety of Viewpoints Jeremy W Variety of Viewpoints 3 days ago It's interesting how he eats less but his body adapts to not feel hungry. 2 Reply Betty Pink Betty Pink 10 days ago this is awesome ❤ Reply Phil Lebedev Phil Lebedev 13 days ago The universe is the mind and we are all one and spiritually immortal. To be biologically immortal being perpetually healthy and youthful should be the easiest thing to do. Just know that it is possible. Reply Andreas Neeb Andreas Neeb 7 days ago In the Interview Dr. Sinclair say that there will be a human study for glaukoma in 18 month. Could you please provide a contact to be part of this? Reply Oliver Geoffrey Blakely Oliver Geoffrey Blakely 10 days ago (edited) If you listen to other experts.. on the subject, they have said NAD or NMN the supplement is nowhere close to progressive exercise, primarily V02 Max. 2 Reply Stuart H Stuart H 4 days ago This interview was back in February how about putting it on YouTube when it’s put on the abc website. Reply n/a n/a n/a n/a 10 days ago It would be pretty revolutionary for women who desire both a family and career. If you could live to the age of 300 then then what would be the problem with having kids and then REALLY focusing on your schooling in your mid 40s once the kids move out? As a women you'll feel accomplished with the whole child business and by the time you start schooling your eggs would have begun to run out. Women would be able to have their cake & eat it all. 1 Reply 2 replies Jen Holmes Jen Holmes 5 days ago I will make it to 120 & have 120 years of problems!…..😢😅😊 1 Reply DrBlaneyPhysics DrBlaneyPhysics 12 days ago (edited) How can you retrieve lost information? Did I miss where the original info was saved? e.g...Which cell has the info and in what form. thank you [anyone] if you know. Reply 2 replies jdacasin jdacasin 2 weeks ago I believe it 5 Reply Huy Nguyen Huy Nguyen 8 days ago What do you think about the work of Dr Michael Levin? Bioelectric? Reply jdacasin jdacasin 2 weeks ago Im only on Dr sinclair style just 3 years ago 1 Reply Ginger&Garlic Ginger&Garlic 10 days ago i reversed parents dementia with liposomal C (drug companies would prefer to keep that secret) 3 Reply 1 reply L J L J 8 days ago Saying cancer will kill everyone if they live long enough is based on what exactly? 😂 1 Reply 1 reply Yodida Bhutia Yodida Bhutia 2 weeks ago 👍 2 Reply jdacasin jdacasin 2 weeks ago I am 59 years old now 1 Reply Alice Walker Alice Walker 9 days ago Cool story but how the heck do I fund an extra twenty years of retirement??? 2 Reply 2 replies Greywolf Greywolf 4 days ago Show me the 120 guy that followed this protocol… meanwhile we had a 114 year old AZ man who loved that long just eating biblical foods like honey, cinnamon, real fruit and vegetables, olive oil, garlic … research already exists on how live into your 100s Reply Iguana Amphibious Truck Iguana Amphibious Truck 11 days ago There is no place in our society for over 80. What do we do with another 40 years. Iguana (87) 2 Reply 3 replies D.C.Milionis D.C.Milionis 10 days ago @34:00 what is the present thereapy for Macular degeneration can NMN help stop or reverse the issue Reply mary nguyen mary nguyen 7 days ago Living healthy is Nice. Living to 120 to see all people around you and your loved ones disappear? I don't want to live alone . Go along with nature. Sickness is a concern, Not the length of time to live 1 Reply 1 reply Zegik Niet Zegik Niet 16 hours ago what aboud taking nmn? Reply Nmambueh Nawe Nmambueh Nawe 4 days ago Living to 120yrs is normal. Can the scientists increase longitivity to 300yrs?? Reply 1 reply pieceofshit pieceofshit 5 days ago so we are still going to die then Reply 1 reply Amelia Ramos Amelia Ramos 11 days ago Sorry..but why that so vague definition of deseasses? Thought that health was the constant on.our lives and illness was the exceptional events... Reply Abdul Rehman Abdul Rehman 3 weeks ago i want to connect to ABC Australia (team) on email Reply How to Not Die | David Sinclair | Knowledge Project 136 Farnam Street (The Knowledge Project Podcast) 115K subscribers Subscribe 6.4K Share 275,176 views May 3, 2022 Biologist and genetics expert Dr. David Sinclair is out to prove he can live past 100 years old, and he thinks you can too. On this episode Sinclair goes in-depth on the process of aging and the techniques you can incorporate into your life that help you live a longer, healthier life, including optimizing your diet, the benefits of exercise, the role of a positive attitude, the importance of sleep, the three supplements he takes every day, why it’s never too late to slow the process of aging, and so much more. Dr. Sinclair is a professor of genetics and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, and he is best known for his research on aging, with a focus on epigenetics. He’s been called one of the 100 Most Influential People in the World by Time, and in 2019 he released the New York Times bestselling book, Lifespan: Why We Age – and Why We Don't Have To. -- 00:00 - Intro 01:24 - What is aging? 02:52 - What happens in our body during aging? 06:10 - How fasting decreases aging 15:00 - On eating three meals a day 18:39 - The best things to eat to reduce aging 23:05 - Organic v non-organic foods 27:04 - Should we only eat food that's "in season?" 29:46 - On sugar 31:42 - How to test your biological age 33:22 - Using exercise effectively 36:18 - Sleep and aging 40:36 - The benefits of saunas and hot tubs 45:04 - The relationship between stress and aging 47:55 - How positive attitude impacts lifespan 48:34 - NMN, Athletic Greens, and resveratrol 52:57 - Why David quit dairy (and did it matter?) 58:00 - When should you start slowing your aging process? 01:01:05 - On puberty and aging 01:02:53 - Are biological problems becoming engineering problems? 01:08:54 - Using drugs to reverse aging 01:11:24 - On lyme disease 01:17:06 - On hip-replacement and increased death rates 01:21:36 - How to think about aging before it's too late 01:23:30 - What's the ultimate age we can live? 01:28:30 - Second-order effects of living longer -- OUR FREE NEWSLETTER: https://fs.blog/newsletter/ 📈 OUR MOST POPULAR INTERVIEWS 🎬 The Full Story of Naval Ravikant: https://youtu.be/mGY2To_HW98 🎬 Bill Ackman - Getting Back Up: https://youtu.be/mIS3LYxgVWc 🎬 Secrets to Healthy Relationships with Esther Perel: https://youtu.be/atXKntdX2UY 🎙 Listen to the show iTunes: https://podcasts.apple.com/us/podcast... Spotify: https://open.spotify.com/show/1VyK52N... GET IN TOUCH 🌍 Our website - www.fs.blog JOIN OUR COMMUNITY https://fs.blog/membership/ ABOUT THE KNOWLEDGE PROJECT Like the mentor you’ve always dreamed of having, The Knowledge Project shares timely yet timeless lessons for work and life. Past guests include Naval Ravikant, Daniel Kahneman, Jim Collins, Angela Duckworth, Seth Godin, Melanie Mitchell, & Esther Perel. Chapters View all 498 Comments rongmaw lin Add a comment... Farnam Street (The Knowledge Project Podcast) Pinned by Farnam Street (The Knowledge Project Podcast) Farnam Street (The Knowledge Project Podcast) 6 months ago Timestamps: 00:00 - Intro 01:24 - What is aging? 02:52 - What happens in our body during aging? 06:10 - How fasting decreases aging 15:00 - On eating three meals a day 18:39 - The best things to eat to reduce aging 23:05 - Organic v non-organic foods 27:04 - Should we only eat food that's "in season?" 29:46 - On sugar 31:42 - How to test your biological age 33:22 - Using exercise effectively 36:18 - Sleep and aging 40:36 - The benefits of saunas and hot tubs 45:04 - The relationship between stress and aging 47:55 - How positive attitude impacts lifespan 48:34 - NMN, Athletic Greens, and resveratrol 52:57 - Why David quit dairy (and did it matter?) 58:00 - When should you start slowing your aging process? 01:01:05 - On puberty and aging 01:02:53 - Are biological problems becoming engineering problems? 01:08:54 - Using drugs to reverse aging 01:11:24 - On lyme disease 01:17:06 - On hip-replacement and increased death rates 01:21:36 - How to think about aging before it's too late 01:23:30 - What's the ultimate age we can live? 01:28:30 - Second-order effects of living longer 66 Reply 6 replies 5 mins left 5 mins left 5 months ago as much of a scientist he is, he does show a lot of human sides in him. No fancy terminology, his messages are easy to understand yet with precision and concise 90 Reply Jagan .Vaman Jagan .Vaman 5 months ago David is a humble and compassionate scientist...though his achievements are great. His personal traumatic experience with losing his mother shows his human side. I read his book lifespan...brilliant! I am on omad, metformin 2G, niacin, quercetin, veg diet no diary no alcohol 40 min walks....I feel great at 61!. I have never felt better even at 30! More power to you Dr David Sinclair! Medicine plus technology is going to revolutionize how we live longer and healthier.... 70 Reply 5 replies Sophie Sophie 6 months ago Fantastic interview. I've watched many interviews with David Sinclair and this was the best by a long mile. You've definitely got a new subscriber here! 56 Reply 2 replies හරි මග උදෙසා හරි මග උදෙසා 5 months ago Professor David has been educating us in order to live happily and healthier with a purpose to serve mankind. Excellent episode. Thanks a lot.Dr.Jayanth Pathirana Attorney 22 Reply 1 reply TRANSFORMATION CENTRAL TRANSFORMATION CENTRAL 5 months ago I too am super-impressed with both the interview and with David. I am motivated by hearing him say that his biological age is 20!!! (at 52). I'm sold on giving some of these "pathways" a go. Particularly NMN, RESVERATROL, and Metformin.... Really appreciated this interview. Thank you 19 Reply 2 replies Adil Duredoran Adil Duredoran 6 months ago What a great interview and the host has been extremely patient and asked great questions 👍. Subscribed 36 Reply Interpret This Interpret This 3 months ago Great interview. It's interesting to talk about this subject, specifically aging and what the average human lifespan is, and what it could become if we only took better care of ourselves. The majority of the population, it seems, doesn't understand the impact of quality sleep, good diet, regular exercise (even 15-20 minutes a day), and sun protection on general health (and looks). I have a couple of friends who wouldn't even try to reduce their coffee intake, even though they've been experiencing major sleep disturbances for years now. 8 Reply Arbiter Arbiter 4 weeks ago (edited) Great interview, Shane. You asked excellent questions and David always does a good job of giving clear and understandable replies. Blessings to you both. 1 Reply Robert Brown Robert Brown 4 months ago My doctor prescribed medicine because he said I should watch my cholesterol that I should keep it very very low. I never took his medication but I changed my diet change my diet I went back to him 6 months later and he said wow did it ever work so good I've never seen the drug works so well and I told them I didn't take the medicine I changed my diet and he changed the subject. He never asked and wasn't curious what I did. 42 Reply 7 replies Bishwas Basnet Bishwas Basnet 2 weeks ago Thank you so much David for all these insights. Thanks Shane. Definitely gonna start with the small changes David shared here especially the fasting thing. Good luck to everyone who has taken a resolution for more healthier life in general. yougotthis 2 Reply shekatagani shekatagani 5 months ago You don't need to go as long as 3 days for Major Health benefits, Eating one meal a day and eating whole foods, cutting Carbs and Sugar, limit Alcohol. Do this with a little exercise and you will be a very fit person. I am 67 and I've taken on this way of living and I'm more healthy now than I was 20 years ago. 212 Reply 31 replies Debasish Borthakur Debasish Borthakur 2 months ago Yes you are right Dr. Sinclair.. Aging is a disease.. We support you..Love from India 🙏 U are my hero.. 2 Reply Emerald Greene Emerald Greene 1 month ago I love the information I cannot get enough of Dr. Sinclair 3 Reply Mary T Mary T 4 months ago (edited) 🔥🔥👏👏👏 … finally someone who really cares about the TRUTH of eating , fasting and why …….. I admire YOU and your courage to speak FACTS and educate others !!!! 🙏🏻🙏🏻🙏🏻 7 Reply MJ Grant MJ Grant 5 months ago great interview. thank you for the time stamps, they are super valuable when wanting to zero in on topics. i wish all interviewers did this. 19 Reply SueAnn Crawford SueAnn Crawford 4 months ago When I contracted Lyme disease I also had paralysis in my face as well as a bullseye rash, and I was treated like I was crazy. The initial testing came out negative so they told me there’s no way I had Lyme disease. When I finally got diagnosed after taking it into my own hands It had been 12 years. As a result I still have remaining paralysis in my face after being on antibiotics for five years in order to get it under control. It’s medieval the way they handle Lyme disease. 7 Reply MD Bonifasio MD Bonifasio 3 months ago This was such a good podcast! Thank you for keeping it simple and letting the messenger spread the message without an exaggerated amount of ads constantly interrupting! Thank you! 7 Reply Jill Ross Jill Ross 1 month ago David Just started following your talks and enjoy them. Very much . I am 82 years old. I have had a triple bypass,cancer and most recently 8 months of black mold exposure, not knowing at the time why I kept getting sicker as time went on. In spite of it all, I strive to get better and and achieve good health. Thank you for all the information and inspiration to do so. Anxious to learn more. 1 Reply Robert Kuiper Robert Kuiper 5 months ago Thank you David for the open heart and inspiration! 4 Reply Atlantico Music Atlantico Music 2 months ago (edited) Great, congrats thank you so much, it is so simple and it is right in front of our eyes that less is more! It is funny how when we discover that the obvius is genius!!! My dad went almost to 100 here in Brasil following old school life style and tips he was a Karate and runner as well, and always use to tell us eat a little bit of everything with moderation and enough to feel it up both hands together not more than your stomach can handle. And not over or too much sex, sports, work and food just make in way that you enjoy enough to have a wish to do it again! Be happy always enjoy everyday life, the mother nature, music, dance, peace and love! 4 Reply Angel Heart Angel Heart 2 months ago Fabulous interview. As an Aussie I am so proud of David. I have just ordered his book. Thanks for the insights. 5 Reply Linda Marsh Linda Marsh 4 months ago Dr. Sinclair's Mom and Grandma would be very proud of him. Helpful and kind man. 7 Reply Nancy Lucas Nancy Lucas 4 months ago Thank you. Great interview, and definitely informative. Doing most of these things, except drugs and monitoring for several decades. You talked about research/clinical studies I definitely am going to go looking up to read. @Shane and @ Dr Sinclair so sorry for all your troubles with Lyme disease and an unresponsive healthcare system. 2 Reply Deb Stay Blessed Deb Stay Blessed 2 months ago (edited) Dr. Sinclair G.O.A.T. Taking on the medical community by changing the paradigm 👏👏 Got his book and he keeps it simple and practical, very doable.😉 1 Reply Myrna alexander Myrna alexander 5 months ago I so enjoy your podcasts! Follow in my life and encourage my clients to do. I am psychotherapist and nutritionist. 6 Reply Adrian Adrian 2 weeks ago I'm grateful your interview with Dr. Sinclair pushed onto my feed. Your questions and the flow of conversation couldn't have been better. Very informative, especially for myself who is in this battle between progressing my strength-training and muscle-building (which requires generally less than a gram of protein per lb) with the desire to increase my lifespan and overall health as I age. Thanks and I'm excited to view more of your content! 1 Reply Bhvn Raju Bhvn Raju 4 months ago Excellent conversation, Amazing scientific INSIGHT, Thanks to THINKER cum WELL WISHER 🙏🙏 3 Reply Aaliyah Lee Aaliyah Lee 5 months ago Life expectancy is the average length of life of a group of individuals. The way to increase this is to get more individuals to live longer than the current average than die sooner. One way to do this is to persuade the members of the group to eat a healthy diet in moderation and to get regular exercise. I have been watching Dr. Sinclair's interview and bought his book “Why We Age and Why We Don’t Have To” very eye-opening and educative. In there, there's no point increasing lifespan without health span. The goal should be to live longer while staying young and healthy. Sinclair believes that in the foreseeable future, it's possible for humans to live beyond 120 or even 150, without the frailty, diseases and disability we now associate with old age. I hate aging and the illnesses it brings over time. NMN Vitruvin Health is the most cost-effective brand for me. 7 Reply Grant Burris Grant Burris 6 months ago David, I follow all your talks. I have for about two years. I liked this one better than the ones with the guy who has the silly hat. This was well done. Just my opinion. Thanks for all the information you have been supplying. It very useful. 34 Reply 3 replies Igor Doizha Igor Doizha 2 months ago really great guy, shares so great information. interviewer is also cool. thank you both! 3 Reply M. Bader M. Bader 4 months ago This and many other talks by Dr Sinclair are so interesting and inspiring. If you're seeing this dr sinclair can you tell me if you are basically consuming all your required calories intake in one go each day? If you are regularly fasting and only eat once, how do you eat possibly 1500 to 2000 or more calories on one meal or are you consuming a low calorie diet? Do you ever let yourself go when on holiday and eat local snacks ? Also curious to know if everyone eventually ends up with some insulin resistance over time? 1 Reply Neo Nomad Neo Nomad 2 months ago (edited) Fruits and veggies are healthy when they are bright coloured/stressed, but also the poisonous ones give the same signal as a warning to stay away. Thanks for the enlightening interview. 2 Reply Suzanna Dwyer Suzanna Dwyer 6 months ago It fascinates me that you and many others talking about longevity are young, 40's 50's t most. I am 80 and often wonder what you will be saying in 10 or 20 years. True I was fortunate to receive the longevity genes, I have brothers who are 84 and 85 and quite healthy too, but there must be other factors at work that you are not detecting. 27 Reply 2 replies Grant Burris Grant Burris 6 months ago David, I made my original comment when the talk was half over. Now that I have heard the entire episode, I want to stress again, how valuable this talk was. This was miles ahead of all the others. Thank you. 12 Reply Josephine Jwang Josephine Jwang 2 months ago I learned a lot from this interview about life extended to beyond 120 years! Dr. David Sinclair is pioneering this human longevity by looking at whales that live to be 200 years! 1 Reply Ken Ken 4 months ago The questions were great and I truly enjoyed the talk. Thank you! Subscribed 3 Reply FRITS FLAP EARS FRITS FLAP EARS 6 months ago I'm happy Sinclair admits his sleep habits are not optimal, its the same as me. Many nights i don't even sleep, i know it's bad, but this is reality. I worry too much and need to change it. But i never wear jackets, even not when its below minus 10°C and i am much younger looking than my brother and cousins who are bald grey already for years 9 Reply g b g b 5 months ago This interview was the best a watchbon the last time. It's blow my mind !! So much precius information. Absolutly excellent . 10 Reply Edgbarra Edgbarra 5 months ago I didn't know he was eating mostly a plant based diet, that's quite interesting to consider. I'm definitely gonna do it too 6 Reply 1 reply Milena DelTorto Milena DelTorto 4 months ago Thank you so much. Great talk! 2 Reply Myrslokstok Myrslokstok 4 months ago (edited) ⭐️⭐️⭐️⭐️ This is a great interview with David, with additional timestaps, thanks! If it is possible maybe you can cut in some wiki-pages here and there for us non english speakers. Ex Limes decise we even got TBE in Sweden 🇸🇪 its basicly the only dangerus thing here, except for a snake if you are unlucky. If I could se the wiki page I wouldn't have to wiki it. 2 Reply Javad Hashtroudian Javad Hashtroudian 4 months ago At 75 I have been practicing intermittent fasting for about 20 years. I exercise most days. Recently I started taking nmn and berberine as well as other supliments . I weigh less than I did 50 years sgo 5 Reply Olaf - Olaf - 4 months ago The real key to human happiness isnt living longer. Its having the ability to turn it off without pain when you want to. 3 Reply 3 replies Kim Wolfe Kim Wolfe 5 months ago Thank you for sharing your life! Notes taken… 4 Reply YeeMing B Chan YeeMing B Chan 4 months ago Thank you so much, grateful to both of you! i 'd like to translate or rephrase the main ponts here and will write your channel as my source, do u mind pls, Shane. i think this is so interesting and impressive , many peple can benefit from watching your interview! so please! 2 Reply Natalie Axl Natalie Axl 15 hours ago Longevity is a Lifestyle 🙏🎊💕 thank you @David Sinclair 🙏 Reply woodworking aspirations woodworking aspirations 5 days ago Beautiful discussion Reply Creighton Freeman Creighton Freeman 5 months ago Regarding sleep, the Yogi Sadghuru says rest is essential, but distinguishes between rest and sleep. Most people do not know how to rest without sleeping though. I have noticed that when doing certain kinds of breath work, I need less sleep. 11 Reply Vassiliki Stathopoulou Vassiliki Stathopoulou 5 months ago Amazing scientist! 3 Reply SNOWY OWL SNOWY OWL 2 months ago I heard a long time ago that the broken hip story is actually back to front. Apparently your hip gives way and then you fall. Reason is that the western sugar/carb diet creates an acid environment resulting in a desperate search by the body for minerals to restore the acid/alkaline balance. (to avoid acidosis) Since we are all generally deficient in minerals, the body must take them from our bones resulting in osteoporosis … ie weak bones which give way or break easily. 1 Reply Melissa Hamm Melissa Hamm 1 month ago Dr. Sinclair love all yr podcasts. I'm 63 I've recently had both hips replaced due to bone irrotion,is my prognosis the same as if I had broken them? 1 Reply B R B R 5 months ago I love this guy...he literally is a gene...ious 8 Reply BoltieBolt BoltieBolt 1 month ago Great work. 1 Reply FreeMocean FreeMocean 5 months ago David is 5 months older than me. Will be interesting to see how we both age over the next 8 years. I’m full carnivore + coffee. I focus on about 20 min day of strength and mobility work. Randle cycle is my priority. I recommend Bart Kay for actual science on human nutrition. Time will tell. 10 Reply 4 replies Just a Guy Just a Guy 5 months ago I did a 7-day hard dry fast about a year and a half ago. Next week I will be starting an 11-day soft dry fast. I totally believe in dry fasting (not water fasting) now. I'll never do another water fast again. I'm now also trying out a 16-8 hour time-restricted eating schedule. I'll see how it goes. 3 Reply Rachel Stark Rachel Stark 5 months ago Even if most people don't believe longevity, they should still support it coz in fact we just have one life after all. Living up to a hundred and being still healthy is beyond priceless. I'm up for Dr. Sinclair's NMN supplementation. It's hard to prove something if you don't experience it yourself. Thanks to Vitruvin Health supplementation, I'll never have to worry about aging and the age-linked illnesses. 1 Reply Donna Oliver Donna Oliver 3 months ago I have a rookie question: If one started these strategies and then couldn't continue for any reason, would there be a 'rebound' effect (e.g. Flowers for Algernon) or would the person just continue from where they are? Sorry if this is a ridiculous questions, I'm not a biologist, but really interested in this work. 3 Reply 1 reply Judith Hatch Judith Hatch 5 months ago actually I'm doing well with the one meal a day , just on my 4th day, but going well. Drink my coffee in morning, followed by water, hot non caffeine tea and water in afternoon. Getting off my butt every hour walk around trying to get 4000 steps a day and more on days off. Whole non processed plants, fruit, egg and fish, beans. 65yo will see how it goes. but can tell fluid retention down, less joint pain already. This is for long haul. As I age in years want quality of life while I'm here. Dr. Sinclair has tapped something in me to be motivated., thank you! 8 Reply Robert Brown Robert Brown 4 months ago It's actually easy to get the 3 days you have to build-up to it once you build-up to it you'll find not eating it's just somehow you realize you have so much more time because there's no cooking and dishes and stuff no time wasted at the table eating and in the 3rd day of the while I've had so much time it feels like a whole week went by. Mind you I live alone. I used to get really sick with nausea after missing one meal now I can go 3 days with no problem no side effects or anything. Just practice it you'll see how easy and you'll get there. 2 Reply Anne williams Anne williams 5 months ago For the last few months, I've been taking one tablet each day of NMN-Vitruvin Health supplement. I'm astounded to discover that my metabolism now functions as well as it did when I was a younger. Other outcomes aren't nearly as visible yet, but I saw a significant boost in energy and concentration. I'm going to order another few rounds from their website. It took around just 3-4 days to see a difference. 10 Reply 2 replies LaaneyChoonz LaaneyChoonz 6 months ago David Sinclair should write a Cookbook! Foods to live longer! 8 Reply 2 replies Oman Oman 5 months ago This has really changed my opinion on the carnivore diet. Like steroids and drugs they make you feel good but it could have long term negatives. 11 Reply 2 replies Henriett Hadler Henriett Hadler 5 months ago (edited) Wow! I have been following David Sinclair for a while now, but this interview was the best. Thank you Shane (? - sorry if misspelled your name) for your questions. You two are a match made in heaven and please keep conversing and do more Q&As in the future. You asked questions that make us think in a broader sense what it means to have a longer life. The impacts on society, environments, etc. I hope you two had a good time- there seemed to be a real mutual respect and synergy that came through the screen. I keep following David Sinclair's works; share this interview with my teens so we can converse more about longevity. As a mum it's my responsibility to raise them well and good foundations for health is part of that. And I subscribe to this channel without even knowing what to expect- but oh boy I enjoyed this session so much, you sold me the rest of stuff you do. Thanks for both of you your time and work and thanks for your teams behind the scenes. 13 Reply DEB WEST DEB WEST 6 months ago I have always slept few hours even though I never do caffeine. I began taking NMN in the morning and immediately felt a jolt like caffeine. Now I can not sleep longer than 4 hours. I want more sleep. 6 Reply 2 replies Tim Mortimer Tim Mortimer 3 months ago A new world of possible right in front of our eyes 2 Reply 01maggie 01maggie 6 months ago My 98 year old Mom sleeps 12 hours every night. She was always napping when I was a little girl. She said even as a child she would sleep until noon on weekends. Friends would come to play and her mother said .. Florence is still sleeping... Maybe she has a lot of melatonin in her system??? By the way she will be 99 this October!! She had covid a few months ago and did well!! Actually better than me... I found the NMN and Transreservatol saved me from long covid. Wish I took it during the acute phase .. Also chaga mushroom..game changer...stops cytokine storm which happens with Covid!! Chaga also kills cancer!! 4 Reply 4 replies Dorin Bivolaru Dorin Bivolaru 4 months ago Brilliant. Very greatful. Thanks 2 Reply Bronson Stone Bronson Stone 3 months ago Great interview. Can David tell us how much protein should be consumed each day. I'm somewhat perplexed because all I can find is recommendations to eat 1.2 to 2 grams per kg of body weight, I weigh 110kg and cannot eat 130g of protein, I struggle with 60g. 2 Reply 3 replies Matt j Matt j 6 months ago Excellent roundoff of some wonderful techniques 3 Reply ilya b. ilya b. 5 months ago currently i stopped intermittent fasting because there is a drawback, you have difficulties to keep lean muscles. As i try to be an advanced athlete, I feel better with proteins and enough nutrients. The last thing you want is to fall and break a hip when you are old (it is like a death sentence) so i need to maintain strong muscles and reduce muscle wasting due to aging. i still adhere to midetterenian diet of course. 2 Reply Gina Baron Gina Baron 4 months ago My father's spiritual teacher in Indonesia called Bantong became 160 yrs 3 Reply Levon Darratt Levon Darratt 3 months ago The laughing muscles get a workout by watching Schitt's Creek . That's anti-aging right there. 2 Reply Sebastian Niemann Sebastian Niemann 6 months ago great interview 🙏🖖❤️ 2 Reply 720 Zone 720 Zone 4 months ago (edited) Interesting fact: David is 94 years old. 9 Reply 2 replies 江寒刀风乱😜 江寒刀风乱😜 4 months ago Hi Dr Sinclair, I have read your journal on 2013 regarding mitochondrial decreasing with ageing. But how about telomere and telomerase participation? 1 Reply Burt the Man Burt the Man 2 months ago It all doesn’t matter. At the end of life we will experience huge disappointment cause we’re all going to die in a relatively short time. 3 Reply Brandon RH Brandon RH 1 month ago That ending blew my mind. "Every year you live you gain another year of life." 1 Reply Ankush Sharma Ankush Sharma 6 months ago Bring more people like him..nothing brave in accepting death¡ 5 Reply Louis Peter Jettoo Louis Peter Jettoo 3 months ago Enjoy life, be happy, self control, discipline, Enjoy working, don't put things off if you can do it today, play sports, be active, dancing, there's time for everything, but don't be lazy. Swim, fish, the Mind and body must be busy and rest when tired, but always looking forward, a bit exited for the next day, there's always something to do. Don't get into a habit of putting things off for later. Love and enjoy everything you do, learn to enjoy the things you don't like to do, I mean don't do things like breaking the law. Love and forgive is a priority. Follow your subconscious or dreams and never give up. Thank you 😊 💓 4 Reply 4 replies Kelly Serafina Kelly Serafina 4 months ago Oh good lord. No wonder I'm sleeping less nowadays. I am taking NMN/Resveratrol at night right after dinner, which I didn't realize was kick starting the energy cycle in my body. My bad. I was trying to keep the OMAD clean by not eating in the morning, the yogurt that I put the NMN & resveratrol powder into, but I guess I'll have to start taking it in the morning. 2 Reply April Michael April Michael 5 months ago One of ny faves Mr Sinclair. You're one of very few docs I listen to whenever you upload new episodes. Cheese & wine ohhh my food. Noooo 🙆‍♀️🙆‍♀️😥 2 Reply 3 replies Jatinder Singh Jatinder Singh 6 months ago (edited) What are the tests available to see your health and age? You may live really long, time is changing. Thanks. 2 Reply Jon Tutlewski Jon Tutlewski 2 months ago Great,Thank You very much ! 2 Reply partypao partypao 3 months ago Fasting - When the body has no materials for building more cells it keeps itself busy by doing house chores: cleaning, reorganizing, keeping tidy the cells that are already there, and maybe throwing out garbage cells that can't be repaired. 4 Reply falcon127 falcon127 4 months ago THANKS, GUYS GREAT VLOG! 4 Reply Agapanthah Agapanthah 6 months ago Great job...subscribed 2 Reply Sue Bostock Sue Bostock 5 months ago HI- thanks so much for this information. Does this mean that (plant based) protein shakes don't help longevity, even if we fast for 14 hours? 2 Reply 1 reply Richard Murphy Richard Murphy 1 month ago Came down with chronic illness trying carnivore and fasting to cure me. 1 Reply Nancy Lucas Nancy Lucas 4 months ago Thank you for the information about turning on mTOR, sirtuitins, and AMPK by eating vegetable-based protein. 2 Reply Benjamin Rogers Benjamin Rogers 2 weeks ago Five days of water-only fasting maximizes autophagy. I water-only fast for 14, 21 and 30 days. As long as you take certain supplements, you don't lose any muscle mass at all. 1 Reply Bri Terry Bri Terry 3 months ago No one ever asks where he gets his Resveratrol and NMN from... really all I wanna know at this point! 2 Reply Paul Hartman Paul Hartman 2 months ago Apples are always in season, depending on the hemisphere. Places like Chile produce them during the North American winter. 1 Reply Alex Berukoff Alex Berukoff 5 months ago OUT OF 22 THIRD PARTY TESTING FOR NMN ONLY THREE HAD ALMOST THE AMOUT CLAIMED ON THE BOTTLE,, THREE HAD NONE AT ALL AND THE REST HAD 1% 2 Reply dihuscientistdj dihuscientistdj 5 months ago Simple wow! Absolutely phenomenal 🥹 3 Reply Gina Khaziran Gina Khaziran 5 months ago Thank you for your time and advise 🙏, which kind of NMN, is good? 2 Reply David Sinclair’s 2022 UPDATED Supplement Protocol | And WHY He Takes It Wellness Messiah with Rimon 7.91K subscribers Subscribe 1K Share 28,531 views Aug 10, 2022 If you’ve been following Dr David Sinclair, you know he updates his supplement protocol from time to time. And in each interview, he gives one piece of explanation to what he does. And certain supplements that appear in one interview, he does not mention them in other interviews. Sometimes it’s hard to follow his protocol today. Since, I know Sinclair’s work since 2007, before he went public in 2019. Here, I have collected for you from a variety of sources, including Sinclair’s book, trying to figure out EVERYTHING he takes today and how much from each supplement. And, you’ll find a very spicy comment from Sinclair about resveratrol. -------------------------------------------------------------------------------------- ✅ Brad Stanfield vs David Sinclair on RESVERATROL https://youtu.be/Hsk-TyjywR4 ✅ David Sinclair's Original RESVERATROL Study: Amazing Discovery & Analysis https://youtu.be/Js_l_G1x8V4 -------------------------------------------------------------------------------------- Becoming a channel member on Patreon & get benefits: Pateron: https://www.patreon.com/WellnessMessiah -------------------------------------------------------------------------------------- DISCLAIMER & FAIR USE Copyright Disclaimer under section 107 of the Copyright Act 1976, allowance is made for “fair use” for purposes such as criticism, comment, news reporting, teaching, scholarship, education and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use. -------------------------------------------------------------------------------------- More Longevity Research Videos from Us: ✅ Suppress TOR by avoiding excess protein How to Suppress TOR Pathway Naturally https://youtu.be/qo7D1I2OyL4 Protein Impact on Longevity Explained https://youtu.be/--LJqBzr-uI How Much Protein EXACTLY You Need https://youtu.be/n8XVQd66fd8 ✅ Integrate anti-aging foods that target longevity pathways. Collagen for Longevity and Young Skin https://youtu.be/9Q3rnFpQWp Collagen Deeper Analysis (Soon) ✅ Reduce inflammation by replacing cheap vegetable oils with healthy fats Omega 3 Supplement and Foods https://youtu.be/PfS4cjph4kE ✅ Move or exercise soon after meals to burn off meal's glucose Yet to be released ✅ Cycle stress and cortisol Yet to be released ✅ Activate deep cleaning inside your body by integrating long fasting ✅ Intermittent Fasting: Intermittent Fasting - How it Works? [PODCAST] https://youtu.be/kY29C9iLnXs How to Do Intermittent Fasting: Complete Guide [PODCAST] https://youtu.be/tz-XeVnB62I ✅ Improve Your Sleep Quality Guide https://www.youtube.com/watch?v=Nd75m... ✅ Increase the intensity of your exercise, but do it intermittently, Cardio HIIT for Longevity https://youtu.be/WNo4fJpZiXA ✅ Take longevity supplements Resveratrol Controversy Explained https://youtu.be/Hsk-TyjywR4 Taking Resveratrol Correctly: https://youtu.be/wsZ1Mj15fAQ -------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------- The Wellness Messiah podcast is available on Spotify, Apple Podcasts, and Overcast. -------------------------------------------------------------------------------------- Credits: Scott Buckley Disclaimer & Disclosure: The information in this video and/or at this channel is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge, educational and information from the research and experience of Rimon, who encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. Rimon is not a medical doctor. If there is a contradiction between the advice here to your doctor or local authorities, always go with the doctor and the authorities. Statements made, or solutions suggested in this video and/or at this channel are not intended to diagnose, treat, cure, or prevent any disease. The statements are not contradictory to first following authorities' guidelines of social distancing and hygiene. Key moments View all 124 Comments rongmaw lin Add a comment... Wellness Messiah with Rimon Pinned by Wellness Messiah with Rimon Wellness Messiah with Rimon 3 months ago (edited) ✅ Brad Stanfield vs David Sinclair on RESVERATROL https://youtu.be/Hsk-TyjywR4 ✅ David Sinclair's Original RESVERATROL Study: Amazing Discovery & Analysis https://youtu.be/Js_l_G1x8V4 13 Reply Santiago Gold Santiago Gold 1 month ago Thanks for organizing these videos and data. It makes things much easier to reference Sinclair 2 Reply Otto Otto 3 months ago (edited) Great video! Thank you!!! After having watched all your videos I'm still insecure about how much resveratrol to take (30-50mg or 500mg or even 1g like Sinclair does??)....Hopefully your forthcoming videos will help finding the right dosage... As far as i know wheatgerms contain much more spermidine than the sources you mentioned. 13 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Triangle Dancing Triangle Dancing 3 months ago This is another very informative video. I just recently found your channel and really enjoy the content, especially when you dive into the details of Sinclair's comments and the studies. Since this one is about supplements, have you considered doing some videos on liposomal supplements? A lot of these longevity substances have very poor bioavailability. Using a liposomal delivery system dramatically increases the amount that gets into the bloodstream (almost all of it from what I've heard) and also facilitates entry into the cells where it is needed. I'm in the process of switching to liposomal (or phytosomes, which is very similar and does pretty much the same thing as liposomes) supplements where they are available for the stuff I take. One last thing, Metformin is mentioned in this video, and that is not typically available to people. You've also mentioned Rapamycin on your channel I believe as a longevity molecule. It turns out there are natural mimetics of those substances. On that reasoning I added ashwagandha, EGCG, and ginseng to my stack. See the study below for scientific support: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723685/ 4 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 3 replies Antony Stringfellow Antony Stringfellow 1 month ago I'm a little surprised David takes so much of so many of these compounds. Most of them are synergistic to the point of actually amplifying the effects of one another. The effects of Metformin and Aspirin, taken together, is more than the sum of each taken alone. The effects of Metformin and Resveratrol, taken together, is more than the sum of each taken alone. Metformin, Aspirin, Resveratrol and Quercetin are all synergistic, with many overlapping effects. I have taken all of these, and in similar doses (but 1 g Metformin per day) but only for 4 weeks, as a purge. I wouldn't want to risk doing this long-term. The only one I take every day is Metformin and that's because it's the only one of these compounds that has been proven to extend human life and has an excellent safety profile. On the other hand, one study on rats showed that Quercetin increased the occurrence of tumours. Starting Monday, I'll be taking the polyphenol, Pterostilbene together with NR as they seem to have a powerful anti-cancer effect when taken together. Pterostibene has 4X the bioavailability of Resveratrol so I'll only be taking 100 mg per day. I'll also be starting with sulforaphane and eating much more broccoli together with mustard seeds (trying looking that one up). When I was taking Resveratrol and Quercetin (my purge) I mixed them together with soya lecithin, on a slice of wholemeal bread. Both the lecithin and the wholemeal bread boost absorption, especially the lecithin, which has a strong affinty with water. I also mixed in 500 mg of VitC which I had in paste form, in capsules. The Vit C and lecithin help to protect the Quercetin, the lecithin in the stomach and the Vit C in the bloodstream, so it has more time in your system before being metabolised. Anyway, thanks for keeping us up to date.... really appreciate your videos! 2 Reply 1 reply JWV JWV 2 months ago Thank you for your honest work! 👍 3 Reply Wellness Messiah with Rimon · 1 reply Christopher Stebbins Christopher Stebbins 2 months ago Hi Rimon, Do you address, or can you address, Berberine as an alternative to Metformin? My doctor is not really up on longevity research, and she refused to prescribe Metformin to me. However, Berberine is touted as a natural alternative to Metformin, with many of the same benefits, plus others. Of course, I purchase Berberine online, so it's more accessible. Thanks in advance, Chris 3 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies antcam007 antcam007 8 hours ago He says in an interview that the resveratrol he takes is "the white stuff, not the brown one" . I thought you would like to mention it in your update. Reply Arnold Pillay Arnold Pillay 2 months ago Thank you Doc... appreciate your advice 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies Bryan Dalle Stelle Bryan Dalle Stelle 3 months ago I think he updated the way he takes resveretrol. I heard ( I don't remember the interview) he now dissolves resveretrol in olive oil and a little bit of apple cider vinegar. 3 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 4 replies Christopher Ellis Christopher Ellis 3 months ago (edited) Have been aware of D3K2 since learning that my mother died from Aortic Stenosis: calcification of the heart. Thank you, margarine. Res and quercetin are in my protocol 3 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 3 replies bernhardwalther bernhardwalther 3 months ago Great video as usual now. Thanks not to take holidays on that this summer 👌👍 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Rodrigo Terra Rodrigo Terra 2 months ago Great video but you forgot to mention that he said that he also takes statins , cause of his family history . I m curious about that cause i have the same issue ! Thank you ! 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Aurielle Nazro Aurielle Nazro 2 weeks ago I do not have a prescription for metformin. So I decided to substitute it with Berberine since it is very effective in reducing blood sugar. I would like your opinion on this…. Reply Tony Castani Tony Castani 1 month ago (edited) Why does Dr Sinclair still take such large doses of Resveratrol even though in his own studies low doses worked better for longevity? In one of his recent interviews he mentioned that he now takes Resveratrol every other day. 2 Reply Ryan Doherty Ryan Doherty 2 months ago So am I to understand just to be clear that he takes virtually all of these supplements at the same time or around the same time in the morning? I don't hear him or yourself mentioning that he takes anything later on in the afternoon or evening. (I heard him mention some people take NMN at night time). Just curious, is he taking D, K2, Resveratrol, Quercetin, Fisetin, NMN, Spermedine, and Tri methyl glycine all in the morning? Thank you! 1 Reply Wellness Messiah with Rimon · 2 replies A T A T 3 months ago I would really like to clarify about Quercetin - it’s not safe to take it every day, it can damage healthy celks, and I dont think Sinclair is doing it everyday either….the study that he brings up (and I can look it up) used quercetin in hit-and-run fashion meaning 3 days in a row then 6 weeks break. Because there is no point to keep taking it everyday - once u remove senescent cells. 22 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 30 replies Android Samsung Android Samsung 1 month ago What about replacing Metformin with Chromium Picolinate and Bitter Gourd? Reply Gym'N'Crypto Gym'N'Crypto 1 month ago What cures for aging is he actually working on? Reply Popel Grüner Popel Grüner 3 months ago May I add to the Spermidine question that you find HIGH concentrations of it in wheat germ. It is up to three times the concentration of mushrooms. At least that is what the web says. 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 3 replies Cesar Villalobos Cesar Villalobos 1 month ago Thaaaaaank you because you speak clearly! Reply Tati Ana Tati Ana 2 months ago I don't get why he's such a guru in aging. He looks his age. He looks middle-aged. Nothing wrong with that but he's a millionaire from all his work and he doesn't look younger than his age at all. 2 Reply 7 replies Kajt23 Kajt23 3 months ago Great video! 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply DingusCirc DingusCirc 3 weeks ago Its not needed to skip Metformin before exercise.... Especially if you are using TRT. Reply C l Reed C l Reed 2 months ago Thank you! 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply CheetahBRFC CheetahBRFC 3 months ago Do you think you can take berberine at night instead of metformin? Whay dose would you take if yes? 3 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Steven Brown Steven Brown 2 weeks ago What about rapamycin? Some are saying it is the most effective, but no mention of it here. Reply MrBrianDuga MrBrianDuga 1 month ago Does anyone know what brands Dr Sinclair uses? He doesn't seem to disclose that in interviews. Reply 2 replies Otto Otto 2 months ago Today i saw a new video where he says that he recently only takes 500 mg NMN. 3 Reply anne thomas anne thomas 2 months ago I'm vegan and was wondering if iI still need b12 as I'm taken nmn and tmg 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Alexander Sverdlov Alexander Sverdlov 2 months ago Does anyone know WHERE is Sinclair taking his supplements from? Most sellers on Amazon sell fake products from noname garage companies.. 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies Burt the Man Burt the Man 2 months ago It all doesn’t matter. At the end of life we will experience huge disappointment cause we’re all going to die in a relatively short time. Reply 2 replies Joya Borthakur Joya Borthakur 2 months ago (edited) How many of you are afraid of death?? Reply 2 replies endicotto endicotto 1 month ago Blah blah. I found that all out on my own. Who knows who’s right? 1 Reply Kim Hjortsbjerg Kim Hjortsbjerg 7 days ago This is bad ! There is no thumbs up symbol below the video ? Reply Nan Kilkeary Nan Kilkeary 1 month ago What is your full name? What are your credentials? Are you a doctor? Do you have a Ph.D? A master's in medical science? Do you have any credentials? You make it look like you have interviewed David Sinclair and others, but I know -- from having followed Sinclair's work (who has a Ph.D., worked at MIT, heads the anti-aging program at Harvard) that you have lifted video form from other interviewers' work. You make statements about studies, but do not show their sources. In other words, nothing that you say can be validated. You may not be a fraud, but you give anyone who truly follows this work no reason to believe you. And the incredible arrogance and narcissism of calling yourself a Messiah! 1 Reply Schu2505 Schu2505 3 months ago (edited) He also takes a statin for a genetic predisposition for high cholesterol. This is strange because he eats coconut yogurt, which is high in coconut oil, which is well known for raising cholesterol. Also, the 2008 Cell study mentioned only indicates improvements in longevity in the EOD feeding and HC diet cases. In fact, in the SD (standard diet) case, lifespan was decreased with low dose of Resveratrol. (Fig 4, graph E: https://www.cell.com/cell-metabolism/pdf/S1550-4131(08)00182-4.pdf) 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · RESVERATROL MYSTERY #2: How It AFFECTS Senescent Cells + Fisetin & Quercetin Wellness Messiah with Rimon 7.91K subscribers Subscribe 935 Share 22,515 views Sep 18, 2022 If you take resveratrol… did you know resveratrol works differently in your body depending on how much you take every day? If you’re not careful about how you take resveratrol, you may achieve completely different benefits from the ones you intended! I couldn’t believe it either until I saw it too. And it is one of resveratrol’s biggest secrets. And it’s kept within its polyphenol family. Which includes fisetin, quercetin, pterstilbene, and others. Today, we’ll cover a hot topic in our longevity community: senescent cells. What are senescent cells? Are they so dangerous for longevity? For that, we’ll hear Dr. David Sinclair, and Doctor James Kirkland, whom in my opinion, the world’s greatest experts on senescent cells. Then, we’ll explore the impact of resveratrol in different doses on senescent cells. We're also gonna cover fisetin and quercetin - what’s the correct way to take them to kill senescent cells? And which dose current human studies are using them as senolytics? And as a response to your requests today I will share what I do personally - my resveratrol dose, when.... ....and my senolytics protocol - because of this investigation. -------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------- ✅ Become a channel member on Patreon. Join with $1 & get access to the 10 resveratrol habits & earn an honorary mention in future videos. ✅ Upper levels receive my entire supplement routine & brands (worth $100). https://www.patreon.com/WellnessMessiah -------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------- Previous videos of the investigation: ✅ Part 1: David Sinclair Study on Resveratrol: Fascinating Discovery https://youtu.be/Js_l_G1x8V4 ✅ Part 2: "How RESVERATROL affects your heart?" https://youtu.be/yT4rqxADvQI ✅ Part 3: Could JUST 1mg of RESVERATROL Affect Your Longevity? https://youtu.be/XFgSA7gbtus ✅ Part 4: RESVERATROL Impact On Metabolism: 2021 Human Study https://youtu.be/MNO4U5wbF08 ✅ Part 5: RESVERATROL MYSTERY: Why Taking Too Much HURTS Your Longevity https://youtu.be/cDTg2rCllM8 -------------------------------------------------------------------------------------- Chapters: 0:00 - Previously in our investigation 2:05 - What are senescent cells 8:25 - Low resveratrol and senescent cells 12:58 - High resveratrol and senescent cells 16:58 - Fisetin and Quercetin 21:14 - How much fisetin is used in ongoing studies 22:00 - What I do, how much I take -------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------- Study References: I'm working on a website to include each video with all links, with each page per video. In the meantime, I ALWAYS show the exact study titles & years and read them aloud. Go to GoogleScholar.com, put the first 4 words only, and the study will come out as the top search, guaranteed. Please double-check me! -------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------- The Wellness Messiah podcast is available on Spotify, Apple Podcasts, and Overcast. -------------------------------------------------------------------------------------- Credits: Scott Buckley Disclaimer & Disclosure: The information in this video and/or at this channel is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge, educational and information from the research and experience of Rimon, who encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. Rimon is not a medical doctor. If there is a contradiction between the advice here to your doctor or local authorities, always go with the doctor and the authorities. Statements made, or solutions suggested in this video and/or at this channel are not intended to diagnose, treat, cure, or prevent any disease. The statements are not contradictory to first following authorities' guidelines of social distancing and hygiene. Chapters View all 198 Comments rongmaw lin Add a comment... Crystal DB Crystal DB 1 month ago I increased resveratrol dosage to 1g based on your last video…. trying to kill leukemic cancer cells. I’m tired of being my own Guinea pig, but I don’t want to go down without a fight. Even a sliver of hope keeps me going. 45 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 13 replies gdok gdok 1 month ago Your videos are not boring at all. It's hardly surprising that there are complexities at play here; the human body is awesomely complex. You do a really good job of using the data and studies available to put the appropriate questions under the microscope and give us cutting edge analysis of the best strategies to adopt. And please be reassured you very clearly and repeatedly stress that you are not giving medical advice. Keep up the good work Rimon :) 13 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Me313 Me313 2 weeks ago Definitely NOT boring! I'll be sixty within a few months and after embracing intermittent fasting several years ago, seeing and feeling wonderful results, I embarked on a longevity supplement journey this past summer. There is a lot of conflicting information out there and I find your videos extremely informative. I appreciate the work you put into researching studies and your delivery of the most current, available knowledge. Thank you! :) 3 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Claudette Sechler Claudette Sechler 4 weeks ago Thank you for keeping us on this path of knowledge! Since things are forever changing, so happy to have someone like you to keep us informed. 3 Reply 1 reply Fia Flodtrollslända Fia Flodtrollslända 4 weeks ago Great video! And I love the comment section. Such great conversations going on. I'm learning so much! I just recently started researching a longevity protocol for my parents. They are bort in their mid 70's and I've noticed some cognitive decline, especially in my father. It scared me and now I'm eager to try to help them as best I can. 2 Reply Mark Anderson Mark Anderson 1 month ago Definitely keep going! In 10 years this will probably be mainstream information but at the moment it is cutting edge. I suspect quite a few of us are running our own personal experiments on what to take and need the best information based on current knowledge. There are a lot of subtle nuances that need to be considered based on our personal situations. 6 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply A T A T 1 month ago This makes a lot of sense to me, and you know how picky I can be 😌👌 The only thing I would look into further is bioavailability and poor absorption of these compounds. Meaning, with low dosing it has to be so precise - and lipo forms do get absorbed so much better. So in that case should the dose be reduced even more? I would really like to know what Resveratrol are you taking yourself, what form/brand 11 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies Matteo Peluso Matteo Peluso 1 month ago keep going Rimon! Great content as always. It would be so useful to see you discuss your findings in depth with Sinclair to get his take on it! 12 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Miss Wellness Miss Wellness 4 weeks ago After listening to David Sinclair, this is a very good balancing video. I’m 57, although I’m disease-free I feel like I’m ageing like a freight train lol. I have enough weight to lose that I might use Fasting along with NMN prior to adding senolytics. What would you do personally if you were approaching 60 and had been experiencing rapid aging? For me that translates to abdominal weight gain, increase in wrinkles, insomnia, fatigue, increasing adiposity in general. Thank you 2 Reply H. H. 1 month ago Thank you for this video. You're the only person that covers this much into details and the way you explain is always so easy to understand. I appreciate you so much! 7 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 4 replies P Jaworek P Jaworek 1 month ago Are you kidding? This project is the least boring thing you could ever make a video about! Keep going and don't leave out anything. Thank you Rimon! 6 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Carlo R. S. Carlo R. S. 1 month ago Very interesting video. I'm 78 & I'm going to take trans-Resveratrol every second day now. Hey Rimon, I'm really interested in mushrooms like Turkey Tail, Cordyceps etc & their nutritional value & effect on the body. Have you done vids on this? Reply Triangle Dancing Triangle Dancing 1 month ago (edited) A couple other things. You mention pterostilbene in this video. I think this would work best as a complement to resveratrol. From what I've read they activate different areas of SIRT1. So using both gives more benefits. Also, I seein future videos you mention olive oil and avocados. I'm guessing for oleic acid? This activates SIRT6 (as well as SIRT1) which needs more research! SIRT1 gets the fame for now but SIRT6 may be just as important or possibly moreso for longevity! Can't wait to see that episode! I've always tried to include olive oil in my cooking. Also love to eat avocados but man they go bad so quickly, it's much harder to incorporate them in to my diet. 2 Reply 2 replies pkwan78 pkwan78 1 month ago Thanks for the useful insight! In the light of all this, could you share with us what might be considered as low dose resveratrol for humans? What dosage of resveratrol are you taking currently and are you taking it daily? Thanks and please keep up your good work! 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 5 replies Rodel Yanga Rodel Yanga 1 month ago Thanks for this , now i understand why my wounds haven't been healing as fast as it normally does. Usually my would will heal in 2 to 3 days , but in this case its been 1 week and it still looks fresh... 4 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Graeme Raynel Graeme Raynel 1 month ago Hi Rimon, my understanding from David Sinclair is that resveratrol needs to be taken with fat for better absorption - he takes his with yogurt. Also trans-resveratrol is supposed to have better absorption. So the 200+ studies you have read and commented on, have you taken this into account, as this will significantly impact the results of the studies? My understanding is that most studies that say resveratrol has no benefits, are those that are not taken with fat. 2 Reply CheetahBRFC CheetahBRFC 1 month ago Thanks again for a great video! Sorry if asked before but what other supplements do you take in your protocol? Do you take nmn everyday? I take nmn 1g, resveratrol 500mg (might drop it to 250mg) every day though watching your videos I might take it 3x a week. 1225g quercetin twice a month. Vitamin d3 4000iu and k2 plus omega 3 every day(EPA 844mg, DHA 574mg. For my skin I wear a spf 50 every morning and take hyloronic acid and astaxanthin supplements. I am 33 white male in South Africa so skin care is important for me (being teased in my youth for acne didn't help). Oh and berberine for those unfortunate cheat meals 🙈 I want to start taking this every night and see how it makes me feel 1 Reply Triangle Dancing Triangle Dancing 1 month ago First of all, these are not boring, keep them coming! This was a very good video, and it confirms what I suspected, that resveratrol isn't a good senolytic. As I have said before, I take a total of 225mg daily, with 100mg being conventional resveratrol and 125mg being liposomal. This technically puts me in what you consider the medium range, but over half is liposomal, so presumably it reaches a lot more tissues and goes deeper into the cells. I also take quercetin every day, 250mg 3 times a day in phytosome form. Besides senescent cells there are benefits to quercetin like reduced inflammation. I know daily doses go as high as 1000mg, and I would guess that anything above that would put you in possible senolytic territory, which means I want to stay below that threshold. It also works as a zinc transporter which can boost your immune system if you're taking zinc (which I do). Recently I got some liposomal fisetin and began the Kirkland protocol, however I added liposomal 95% standardized OPC grape seed extract since pcc1 has shown evidence of being an excellent senolytic. I took these three days in a row, at 450mg fisetin and 600mg grape seed extract (I know the fisetin is below the Kirkland protocol, but my guess is liposomal delivery means you can go with less). However, after watching this video, I'm not sure how much benefit I can expect since I'm aged 45 and it looks like you need to be about 60 before you really need to kill off senescent cells. We definitely need more low dose fisetin studies. The liposomal pills I take are 150mg, so it would be nice to see what that dose would do. And we also need a LOT more studies looking at liposomal supplements. The few I've heard of show it makes them much more effective. Reply 3 replies matzefritz matzefritz 1 month ago It's not boring. It helps me adjust my longevity protocol. 4 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Longevity Lover Longevity Lover 1 month ago Thanks for this video. I went back to the previous video about resveratrol and cancer and thet both complement each other nicely. 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Nicholas Traianer Nicholas Traianer 1 month ago Wow, not what I expected! Thank you again for the excellent content. 2 Reply cassopeia9 cassopeia9 1 month ago Thank you so much, Rimon on this video. I did ask about Fisetin in light of dose dependency of Resveratrol. If I get you correctly, you think that 1.5g of fisetin in one day once per quarter for 70kg 55-60 year-old people? I know that nobody can tell until more solid studies emerge. I somehow feel that it’s too little. This strategy is acute stimulation instead of chronic which does make sense. However, why so different from Resveratrol of 100g every alternate day? 100g every other day also totalled up to 1.5g Resveratrol per month. Would like to understand why “chronic” intake of Resveratrol but acute intake for fisetin? And why not 1.5g in a day per month but per quarter? Could it because you’re being cautious in light of the Resveratrol surprise and that fisetin studies even more lacking? BTW, what do you think of spermidine? 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply BlackLeg199 BlackLeg199 1 month ago Thank you for your effort, u r inspiring. So, what about fasting and resveratrol? Is it optimal to take resveratrol on fasting or non-fasting days? and should NMN should also be cycled with resveratrol? Reply jxgardner jxgardner 1 month ago Unique viewpoint on senolytics and Sirt activation.. These supplements should definitely be cycled , not taken every day. Dosage is another factor .. I assume David himself has ramped back the dosage of resveratrol a lot.. Re consulting a doctor…good luck! ! 6 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies J Singh J Singh 1 month ago It is really great research, thank you for making this video. What does not make sense to me is that Sinclair continues to take 1g resveratrol per day. He would be aware of this bifurcation in response depending on dose, but he takes a high dose anyway. Perhaps he thinks the synergistic effect with NMN is of greater impact than the apoptosis promotion Reply Wellness Messiah with Rimon · 1 reply One in a Billion Fun One in a Billion Fun 1 month ago Good job mate. But honestly have you seen Sinclair last year? He looks younger than before. He looks like 30 now. So I think all he does make sense, even though I agree with you low doses of resveretrol and quercetin and fisetina are not needed in our 30s. By the way have you found anything for combatting grey hair? 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies Steve Crawford Piano Dreams Steve Crawford Piano Dreams 1 month ago Keep it up, it is not boring at all and I am making some changes to my protocol based on this information. 3 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Joshua Joshua 2 weeks ago Another aspect of Dr. Sinclair's regimen taking Quercetin with Resveratrol is inhibiting CD38 to proportionally increase NAD+ as he ages. Reply Earwaxfire909 Earwaxfire909 1 month ago Take a look at the paper:"Grape Seed Oil Compounds: Biological and Chemical Actions for Health." It seems that grape seed extract might be worth investigating. It contains trans-resveratrol and other polyphenols. 1 Reply 01maggie 01maggie 1 month ago I understand you in this video. I already cut back my Transreservatol to 200mg but will go lower now. 4 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Peter Peter 1 month ago (edited) Agree, you're too young to treast SCs. I'm in my 60s and started taking Q and F monthly for 2 to 3 days at the doses used in Dr. Kirkland's trials. I'm not sure that Q and F are used togther so will recheck trial protocol. I alternate between F & Q (every 2 weeks) and divide into two doses per day. I am also not sure if doses are given as a bolus (all at once), or spread out over the day, and whether to use fat or black pepper to help with absorption. I take with a little fat (black olives or cocoa beans) I started donating plasma once a month (25% of plasma volume) at my local blood bank based Conboy studies, which among other things showed reduction of senescent cells in the brain. Very important topic, so hope ypu keep investigating and posting your findings. Thanks! 4 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 3 replies Pablo Gomez Pablo Gomez 1 month ago Crazy complexity. I think we will have true health optimization when some kind of technology in the future helps us monitor our bodies every day. Maybe some kind of nanorobot circulating the body and sending data through bluetooth or something like that. 1 Wellness Messiah with Rimon Reply Random Stuff Random Stuff 1 month ago Hi. Brilliant video thank you!! I am a 57 year old woman. I have been taking 500mg of good quality nmn and 500mg good quality trans resveratrol per day for about 2 years. As far as I am aware, I am healthy, but am feeling my age!! I am very interested in your information on resveratrol dosage and am now going to reduce my resveratrol dose down to 100mg per day. As at my age I am likely to have senesent cells, I am going to take 1.5 grams of Fisetin for 2 days per month. Many thanks for your wonderful information Reply 1 reply Doug Nettles Doug Nettles 1 month ago Rimon, please tell me your opinion on how much Fisetin to take as a "Hit & Run" dosage for a 65 Kg man 67 y/o. It's very confusing on dosage due to the new info on Resveratrol. 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Donna Welborn Donna Welborn 1 month ago I really like all the info you give us. 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply DT DT 1 month ago Rimon, why then Sinclair takes high dose of Resveratrol according to his protocol even in his most recent interviews he is referring to high dosage reference of Resveratrol? And thanks for the update 😊 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies Phaik Lian Ng Phaik Lian Ng 1 month ago Thanks for the latest info. I have been taking low dosage of resveratrol, Fisetin & Quercetin 2 days per week. 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Serge Stauffer Serge Stauffer 1 month ago Great insight. I wonder if your conclusions still are true, when Resveratrol is taken together with NMN. Reply Phoenix girl 11 Phoenix girl 11 1 month ago So. What is the best way to take Resveratrol and Quercetin ? Is it alternate every other day Resverarol and Quercetin? On the day that you don’t take Resveratrol you take Quercetin and on the days that you don’t take Quercetin you take Resveratrol? 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Miles Price Miles Price 1 month ago Excellent work keep it up 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Ronald Park Ronald Park 1 month ago So may I ask whats the standard of low and high dosage for Resveratrol? Im taking 2G (1G Separately) daily Reply Wellness Messiah with Rimon · 1 reply Kimmy Nordahl Kimmy Nordahl 1 month ago (edited) I got sick from resveratrol making my blood pressure extremely high and I had to visist the ER several times before I understood that it was the resveratrol which made me sick. I took resveratrol every night with a high fat meal for a long peiod of time in doses between 600 - 1200mg and I've never been so sick in my life. My heart really worked hard and I got hypertension headaches & muscle weakness. I'm not a sensitive person at all and I've worked with supplements and taken alot for 10 years and never before got sick by supplements. I'm 31 and I'm a fully healthy individual who has never had high blood pressure before. I took resveratrol because nothing helped my tinnitus better than resveratrol for some reason. I'm not saying I believe it's necessarly bad just because I got side effects but definitly alot we dont know yet. Maybe Its better to take lower doses and less often as said in the video. This all happened 6 months ago and now when I took resveratrol 600mg just 5 days in a row again. I started to get some degree of the exact same symptoms back, which is scary, heavy chest, pounding heart, unregular heartbeats, diarrhea, weakness and terrible insomnia 1 Reply 2 replies Abood Cohen Abood Cohen 1 month ago thanks for the video bro, keep it up! <3 3 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Piet Buizer Piet Buizer 1 month ago very good to follow and understand how the different supplements work.. 1 Reply ツ destryeVSquad ツ ツ destryeVSquad ツ 1 month ago thank you for this invaluable video and information. have a great day 4 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Lawrence Patrick Singson Lawrence Patrick Singson 1 month ago OMG I've been taking 350 mg of Raw Fermented Resveratrol by Garden of Life. 2 month supply. Now I'm taking Pterostilbene 100mg instead of resveratrol. I've been kind of guinea pigging myself. Am I taking too much Pterostilbene? 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 5 replies Gilberto Gouvêa Gilberto Gouvêa 4 weeks ago (edited) Hi, Maybe I know why Sinclair takes 1g of resveratrol. It is because the absorption of resveratrol. You need to multiply the resveratrol dose and the absorption rate. Please, what have you found about absorption rate of resveratrol together with fat? 1 Reply Jerry West Jerry West 1 month ago When doing the senescence purge I think it best to do while fasting. Reply Tamen Ewasiuk Tamen Ewasiuk 1 month ago Is there any particular brand of resveratrol supplement you recommend? Thx! Reply Juliana Juresic Juliana Juresic 1 month ago Hi Ramon, I didnt understand the part where you said that if you were 70 you would take Fisetin every quarter for one day. Did you mean every quarter of the year for one day? Reply zer0nix zer0nix 1 month ago Sinclair mentioned some peptide discovered by Chinese researchers that reverses senescence rather than killing those cells,but he kind of garbled the pronunciation and I can't find anything on Google that resembles what Sinclair mentioned. Does anyone know what I'm talking about and can mention the peptide / molecule? Reply Carlos Trujillo Carlos Trujillo 10 days ago Thank you for the great videos!!! Reply Jill Sierra Jill Sierra 1 month ago Good information and please continue! 3 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Gospel of Thomas: 77th Pearl Gospel of Thomas: 77th Pearl 1 month ago Very interesting. Thank you 🙏🏼 Reply Stream Box Stream Box 1 month ago Informative. Please continue. 1 Reply K J K J 1 month ago So what is the optimal dose, Rimon? Reply Phoenix girl 11 Phoenix girl 11 1 month ago Excellent,excellent video!!! 1 Reply Tom Tom 1 month ago not at all boring! Great info! Reply KuumbaOnline KuumbaOnline 1 month ago What is considered high dose resveratrol? How much and frequency... What are the numbers? 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Tony Magnone Tony Magnone 1 month ago Excellent information Thanks for your work 1 Reply David A David A 1 month ago You still have not addressed the question of why Dr. Sinclair takes a full 1 gram 1000mg of Resveretrol daily? 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply BITCOIN TO $1,OOO,OOO,OOO,OOO,OOO BITCOIN TO $1,OOO,OOO,OOO,OOO,OOO 1 month ago Question, do mice absorb resverstrol better than humans? 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies Ryan Tiltman Ryan Tiltman 1 month ago Also doing 1g p/d.. What do you guys recommend? Thank you. Reply Pottenger's Human Pottenger's Human 1 month ago Just take something that stimulates more repair for less potential damage. I don't think there is any compelling reason to take res when you could just take a teaspoon of olive oil. Of just fast for 72 h and get many times the benefit. 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies Rose Solis Rose Solis 1 month ago Not boring very very informative 👌 1 Reply Wellness Messiah with Rimon · 1 reply shawn shelt shawn shelt 5 days ago May those babies who lost their lives ( 11:10 )and then got there remains experimented on be remembered, there will be a reckoning at the last day. Reply Birgitta Devlin Birgitta Devlin 1 month ago (edited) Have I missed something? If low reservatrol stimulates cancer cells (besides repairing healty cells), why would anyone opt for that? Who knows if they do or do not have a tumor cell...? 1 Reply Wellness Messiah with Rimon · 1 reply Steve Roufas Steve Roufas 1 month ago Hello, so what is a low dose ? For myself, I am just under 6 feet and 155 pounds 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply mark veen mark veen 1 month ago Look into dried mulberries. Much more natural resveratrol than grapes. Reply VC VC 1 month ago Yes keep going. Not boring to me 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Dan Curran Dan Curran 1 month ago Novos recommends taking Pterostilbene instead of reserve a troll so I take 150 mg a day how about that isn’t that better than reserve route troll? 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Stefanos Chatzopoulos Stefanos Chatzopoulos 1 month ago why it is better to preserve an old cell instead of forcing it die and create a new one? 1 Reply 2 replies Azadeh Khajeheian Azadeh Khajeheian 1 month ago Great info ❤️ Reply Wellness Messiah with Rimon · 1 reply Wellness Messiah with Rimon Wellness Messiah with Rimon 1 month ago (edited) Please be careful when using senolytics, and please consult your doctor. I hope I stressed this enough! ✅ Patreon - Get the 10 Resveratrol Habits Now https://www.patreon.com/WellnessMessiah Previous episodes: ✅ Part 1: David Sinclair Study on Resveratrol: Fascinating Discovery https://youtu.be/Js_l_G1x8V4 ✅ Part 2: “How RESVERATROL affects your heart?” https://youtu.be/yT4rqxADvQI ✅ Part 3: Could JUST 1mg of RESVERATROL Affect Your Longevity? https://youtu.be/XFgSA7gbtus ✅ Part 4: RESVERATROL Impact On Metabolism: 2021 Human Study https://youtu.be/MNO4U5wbF08 ✅ Part 5: RESVERATROL MYSTERY: Why Taking Too Much HURTS Your Longevity https://youtu.be/cDTg2rCllM8 3 Reply Isaac White Isaac White 1 month ago good info 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Brian Withers Brian Withers 1 month ago Im pretty sure you are interpting the low dose in these studies incorrectly. Low dose is less than 5 uM, but even 1g in humans only reaches 2.4uM peak blood plasma. Res has extremely poor bioavailability unlike rats. So 1g is a low dose for humans. Youtube doesnt let me post links, id love to chat about this and show you what ive found Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 3 replies carpe diem jonah carpe diem jonah 1 month ago Rimon I appreciate your efforts to clarify the results from so many conflicting studies. I also follow Dr David Sinclair’s channel and read his books. By my own nature, I have never taken the megadoses which David Sinclair and other doctors recommend. I take the smaller doses, just to have some on board. I depend on a diet high in a wide variety of nutrient dense foods to do the heavy lifting for my health. Since you asked, I have one suggestion, that might improve your readership. Consider showing the full title, date, and with authors. Perhaps a direct link to the original study. For the reader it is important to sort out the wheat from the chafe. Perhaps the study is outdated by more recent studies. Perhaps the study is poorly designed. Such as a study with no placebo control. Is the study only on mice? On humans? In vitro? In vivo? What are the demographics of the study? Who, what age, country? How many persons enrolled and randomly controlled? Was the study performed over a period of a few months? Or, over a much longer term of many years? ETC ETC You do not need to point out any the details of each study. But when providing medical advice to the public, you do have a responsibility to cite the exact source of your study. Then the public can choose for themselves whether to look into a study more closely. Or the public might print out and bring your report to their medical provider. Without the studies cited, the doctor will not waste a moment to go any further. In the eyes of a professional medical doctor, your un-cited report is worth no more a mere rumor. Citing your sources clearly and fully takes up little space. This might raise your credibility immensely. 90% of “authentic” research scientists, and medical advisors to the public already publish in this way. The rest are wannabe gurus. 7 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies shrodingersman shrodingersman 1 month ago Looking at the latest research with regard resveratrol is simply playing Russian roulette with your health 1 Reply Igal Marcelo Zimmt Igal Marcelo Zimmt 3 weeks ago Fisetin targets the mTor of the senescent cells Reply shakedman shakedman 1 month ago Thank you. 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Joe Blow 6 replies AUTOPHAGY ACTIVATION: Why Most People Exercise WRONG for Longevity Wellness Messiah with Rimon 7.91K subscribers Subscribe 2.2K Share 67,238 views Oct 30, 2022 Did you know that exercising for longevity is different from exercising for performance or for building muscles? Listen, if you exercise incorrectly, you may not gain the longevity benefits you think you’re getting. It is possible to improve your performance and lose weight, without activation of the full power of exercise. Yes, that’s right. To keep your body young, your muscles young, and your brain sharp, you must exercise with intention, with longevity in mind. This way has to do with a dormant mechanism in your body that you want to activate: autophagy. This mechanism can not only help you stay young, but protect you from losing your memory with age, and even developing Alzheimer’s later in life. Today we’ll hear Dr. Eileen White, one of the world’s experts on autophagy. We’ll also hear Dr. David Sinclair explains how to use exercise to activate it too. We'll cover: 0:00 Intro 1:45 3 Documented Exercise Cases 7:38 What is Autophagy? 10:46 How Autophagy Makes Us Live Longer? 14:50 2 Ways Exercise Activates Autophagy 20:47 HIIT High-Intensity Interval Training 24:34 When Exercise Accelerates Aging 30:27 5 Ways to Exercise for Longevity 30:45 #1 Frequency 33:00 #2 Intensity Sweet Spot 36:00 #3 Covering All the Muscles 37:50 Resistance vs Aerobics Exercise 39:10 #4 Avoid Over-training 40:19 #5 Sleep and Nutrition 43:35 Summary of Insights 45:55 Exercise vs Fasting for Autophagy 48:40 What I Do - Rimon’s Routine * I’ve recorded this video before my wife’s stroke. This is what happened: https://youtu.be/UPq-aYrUtK8 If you’d like to support my situation (and get bonuses): https://www.patreon.com/WellnessMessiah I had little time to edit this in the hospital, I hope this doesn't suck! ✅ Join with $1 & get access to the 10 resveratrol habits & earn an honorary mention in future videos. Upper levels receive my entire supplement routine & brands (worth $100). https://www.patreon.com/WellnessMessiah -------------------------------------------------------------------------------------- Thanks to Richard from Modern Healthspan Channel. for permitting me to use his video: https://www.youtube.com/watch?v=UOp0Q... ✅ Suggest watching next: Improving your sleep quality https://youtu.be/Nd75mUmFC9Y -------------------------------------------------------------------------------------- Study References: https://www.renalandurologynews.com/p... https://bmcsportsscimedrehabil.biomed... https://www.ncbi.nlm.nih.gov/pmc/arti... -------------------------------------------------------------------------------------- ✅ The favourite videos on this channel - playlist: https://www.youtube.com/playlist?list... -------------------------------------------------------------------------------------- The Wellness Messiah podcast is available on Spotify, Apple Podcasts, and Overcast. -------------------------------------------------------------------------------------- Credits: Scott Buckley Disclaimer & Disclosure: The information in this video and/or at this channel is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge, educational and information from the research and experience of Rimon, who encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. Rimon is not a medical doctor. If there is a contradiction between the advice here to your doctor or local authorities, always go with the doctor and the authorities. Statements made, or solutions suggested in this video and/or at this channel are not intended to diagnose, treat, cure, or prevent any disease. Chapters View all 205 Comments rongmaw lin Add a comment... Wellness Messiah with Rimon Pinned by Wellness Messiah with Rimon Wellness Messiah with Rimon 2 weeks ago I’ve recorded this video before my wife’s stroke. This is what happened: https://youtu.be/UPq-aYrUtK8 If you’d like to support my situation (and get bonuses): https://www.patreon.com/WellnessMessiah I had little time to edit this in the hospital, I hope this doesn't suck! 20 Wellness Messiah with Rimon Reply 4 replies wck wck 11 days ago Interesting content. I'm sure it took a lot of effort to pull it together and I hope your wife does fully recover. I have never thought of exercise as really promoting longevity, but it is likely a good tool. When it comes to autophagy, I'm deeply in the fasting camp, but I do exercise while fasting, especially if the fast is more than a day in length. Still really something to think about, thank you for your effort. I think exercise enables but doesn't guarantee anything. For example exercise isn't great for losing weight but it does build a base for good metabolic health. Additionally, about apoptosis, isn't that a frequent outcome of autophagy? In fact isn't that normally how muscles maintain? It isn't clear that apoptosis is a bad thing when it comes to muscles. I'm pretty sure that just a brisk walk can trigger some apoptosis in some muscles. Your goal is radically different than mine and I can't claim you are wrong any more than you can be sure your 14 day rest strategy will work long term. I kind of think you'll hit a point where you can't do as much but instead of finding a slight decline in muscles it will be much larger by then. The body often tends to use muscles differently than we expect. I also think it is difficult to come up with a set of HIIT exercises than hit all muscles. For what it is worth, I'm working on body weight exercises not just for muscle or leanness, but also to force my brain to learn new things. A bit of brain exercise, I hope. Still it really does seem that HIIT is very valuable and can save a lot of time, even though it can be painful or at least difficult. The examples that show exercise doesn't greatly promote longevity are rather extreme. For example body builders often only care about growing visible muscles and take extreme risks getting body fat very low. Other athletics were examples of people that train why beyond what most people would do. At best this is colorations and not sure conclusions can be really drawn from it. Averages tend to be tricky with longevity because people die for a lot of different reasons. 9 Reply Susan Woodward Susan Woodward 2 weeks ago (edited) Another superb, science-based, clearly explained video with loads of practical value. Yes, to BOTH fasting and exercise. As someone just beginning to get back into exercise after 3 years of being quite ill and bedridden and losing all my muscle mass, along with quite a lot of weight (not overweight to begin with). Was, and still am, doing intermittent fasting and rotational keto. Thank you and best wishes to a speedy and complete recovery for your wife. 11 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies Connie H Connie H 2 weeks ago This is such a great video Rimon, so much practical information that can be applied to health habits/routines immediately. I personally loathe exercising and would rather rely on fasting and keto for weight control, but it has to be done for longevity. I've only recently been tempted to start gentle yoga again so this has given me the push to include a few short dumbbell workouts, once my bones have stopped creaking 👵 I think it's the way forward leading up to Christmas, as good intentions of Keto will be out the window once mince pie season is upon us. I really hope your wife is making good progress and with your studious approach to health I'm sure she will reach her recovery goals. It will be great to see her on the channel when she's ready. Keep your eyes on the prize!💪 4 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies Christopher White Christopher White 11 days ago Concerning excercise frequency, I'll add, as an anacdote, that I have come to perform only one set of each particular high intensity exercise. I find that my recovery is much faster, I feel more motivated to exercise on subsequent days and my performance gains have improved. 3 Reply peregrinodisastrado peregrinodisastrado 2 weeks ago Hey buddy, my best wishes to your wife. Hope she gets better soon. You say one of the things that helps is hypoxia. I've been following the oxygen advantage on and off for a couple of years now, and it's pretty much the only thing that's helped me with exercise induced asthma. Tldr it's basically breathe through your nose as much as possible, especially during strenuous exercise and breath hold training on exhalation. Have you heard of any studies on this for longevity? I mean, there's certainly hypoxia, I can feel my legs get weak after 35 paces pushing a load while holding my breath 5 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Status 101 - Daniel Ho Status 101 - Daniel Ho 6 days ago My own exercise frequency mirrors yours. I’ve found that working out 10 minutes twice a month (4 hours a year!) is enough if the intensity is high. My body needs the 2 weeks of recovery time, otherwise I regress with more frequent workouts. I’ll still fit in low intensity walks and bike rides for leisure. 1 Reply Nora Zelaya Nora Zelaya 11 days ago I go to the gym every other day for no more than two hours for 30min aerobics and the rest of weight/resistance. I used to do it every day, but I was losing too much weight, regardless of having increased my protein and fat intake. I also do intermittent fasting two low-carb meals a day. One meal will keep me too skinny, and it would probably affect my nutrition status (I was D and B12 deficient). This has worked great for me and has taken care of my prediabetic diagnosis. Great information! 2 Reply Francis de la Cruz Francis de la Cruz 9 days ago (edited) Just discovered the channel. Nice relatively detailed video on longetivity and the levers we can control for it. More importantly Healing and prayers to your family during these difficult times. Reply Bandicoot44 Bandicoot44 7 days ago When doing resistance training, I was wondering what you think is better. For example, should I do a split routine by training a body part with 7 days rest, or is it ok to train three times per week, but do a little bit of everything with fewer sets? Currently, I'm training three times per week and take a day off between workouts, but I train my entire body. I'm worried I may be overtraining. Reply tarish kaushik tarish kaushik 11 days ago All good wishes for your wife's total recovery ! Thank you for a wonderful & informative video ! 3 Reply bernhardwalther bernhardwalther 2 weeks ago Outstanding video as usual. Il really like the way you explain this difficult topic. It makes it all really more sense after your explanation. Thanks to keep posting in this difficult time. Best wishes for you and your wife. 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Jamie Lee Jamie Lee 9 days ago I’ve listened to many health/fitness talks and this video is one of the best contents collectively. Super interesting and informative. TY very much! Reply Khe_Sanh Khe_Sanh 12 days ago Rimon, You have great communication skills with backup verified information. I really enjoy your videos. Thank you for your hard work. Reply Aldo Λ Aldo Λ 13 days ago (edited) The healthy frequency of exercise would vary greatly depending on our diet; when I am in deep ketosis I can train much more with less recovery time and much less muscle catabolism according to my sensations and measurements with a bioimpedance scale 2 Reply Wellness Messiah with Rimon · 1 reply Eric H Eric H 10 days ago (edited) If I understand this properly, when you exercise for autophagy, the benefits occur for the muscles associated with the exercise. So, I have three questions. 1) How do you target organs and any other non-muscular body parts for autophagy with exercise? And 2) Does fasting for autophagy similarly only benefit limited body parts? 3) Is there a third method to stimulate autophagy besides fasting and exercise? 1 Reply 2 replies Emily-Kate C Emily-Kate C 9 days ago Wow this was amazing ! I must say that I have researched these topics to a moderate-high degree over many years, and this ONE video managed to merge MULTIPLE streams of info in one concise video. It’s near genius!!! I am so very happy I have found this channel. Just this one video has been able to build an extreme amount of trust in how comprehensive and common-sensical the prep must be to put out just one piece of content. Wow. 1 Reply Michael Dillon Michael Dillon 3 days ago It was great to hear sir Stanley Matthews given a mention . He was an icon in the UK 🇬🇧. Reply Greywolf Greywolf 9 days ago Love the video and your diligence in research Bravo sir … 1 Reply billbucktube billbucktube 2 days ago Excellent summary. Prayers for your wife. Strokes can be very scary. Reply Jiv Rouss Jiv Rouss 8 days ago So useful!So happy that finally found your channel! Reply DayanaCroft777 DayanaCroft777 5 days ago Such a well made video :) Thank you for the whole information. My best wishes for your wife :) 1 Reply Phoenix girl 11 Phoenix girl 11 2 weeks ago Speed recovery for your wife. God bless both of you. Best wishes ❤️ 3 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Sema Aral Sema Aral 13 days ago Rimon, happy to see you again, Hoping your wife is making a good progress , I keep on sending my prayers to her. Thanks for another useful video . God Bless🙏🙏🧿🧿💙💙 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Wendy D. Wendy D. 11 days ago (edited) What kind of weight training can lead to heart and other muscle (e.g. leg) autophagy? You either do fewer reps with heavier weights or the other way, the heart muscle and leg muscles can’t reach the same intense level through one exercise. Also, is it better off to isolate muscle group or train through complex movement. There are so many concept being mixed here 2 Reply Matteo Peluso Matteo Peluso 2 weeks ago Great video Rimon. One thing I would say is that the detrimental effect of exogenous steroids on longevity coupled with the often terrible diets (for longevity) of pro bodybuilders would lead me to throw out the pro body builder paper from the analysis completely. All other factors you mention seem to point to body building as the most effective solution, even more than just HIIT. It makes sense if you think that often body-building routines involve high repetition sets (12+ reps) with short breaks (0.5->1.5 min) rests. This seems to satisfy that condition for rising and lowering oxygen levels. Also if you consider that the bodies response to high repetition resistance training is mass accrual, it follows logically that an attempt is made to keep as many living cells alive as possible. In fact, failure to complete a repetition often comes long before injury is possible due to the local production of heat shock proteins that inhibit the cells ability to work. Thanks again for the video :) 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 3 replies Antony Stringfellow Antony Stringfellow 2 weeks ago This fits in well with my favorite and most frequent form of exercise, which is going for a long walk/hike in the hills. My weekend walks usually last from 5 to 8 hours and that's exactly the type of exercise it gives me - without needing to run (which I don't enjoy). The ascents, which can be anything from 5 minutes to an hour, are intense - as intense as running - as my body is goes flat out to maintain a fast walking speed up a steep incline. Then there are periods of descending and level walking where I'm using very little energy. This is repeated many times throughout the day. The weight of my backpack helps too, expecially when my water bottles are still full. On weekdays, when I have less free time, I always go for a walk around the block once or twice. That involves a steep ascent too, where I walk as fast as I can, pushing my body. If, like me, you don't enjoy running or working out in a gym but live in a hilly area, there's a great alternative. Besides the physical exercise, I find it also helps me to unwind, think more clearly and it improves my mood. I guess cycling in a hilly area would work the same way. 4 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies Joe Blow Joe Blow 2 weeks ago (edited) I didn’t hear if my method of doing interval training and or weight training during the last hour of my daily time restricted fast would enhance autophagy . I’m doing 20 hours a day and I start my workout on hour 19 so in 1 to 2 hours I’m finishing exercise and breaking fast. I need to be active everyday unless I’m tired. 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Ed White Ed White 2 weeks ago Would you derive the hypoxia benefits by using any of the various breathing devices that make it more challenging to get enough oxygen? 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Dean Mindock Dean Mindock 23 hours ago Rimon, what do you think about the use of a near-infrared (NIR) sauna as a tool for longevity? Reply Franziska Helene Franziska Helene 13 days ago Many thanks for the great work! 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply jshaw007 jshaw007 2 weeks ago Prayers for your wife and you!🙏 3 Reply musaire musaire 2 weeks ago This channel needs million subscribers! 3 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Ed White Ed White 2 weeks ago Praying for a full and speedy recovery of your lovely wife 3 Wellness Messiah with Rimon Reply Antony Stringfellow Antony Stringfellow 2 weeks ago Wishing your wife a full and speedy recovery. 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Idris Stonbirk Idris Stonbirk 11 days ago Exercising is like a restart whereas Fasting is like hibernating. Reply Jenffy Baez Jenffy Baez 12 days ago What about walking and push ups. Should we do it consistently? Reply Antony Stringfellow Antony Stringfellow 2 weeks ago Re-fasting/calorie restriction.... These are proven methods to increase autophogy but there are also various supplements from fruit and vegetables that have the same effect, without having to go through the discomfort of being hungry. Important to note that either alone can produce this benefit but studies indicate that this benefit is not amplified by doing both - the natural supplements only seem to increase autophagy in people who don't fast or have a calorie-restricted diet. So, maybe choose your prefered alternative but don't waste your time/money doing both. 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Pottenger's Human Pottenger's Human 2 weeks ago Running races just beats you down. Getting stronger without taking PEDs seems to be the best thing for longevity, with some moderate cardio or better yet HIIT or SIIT. 3 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 3 replies Ted Wilson Ted Wilson 12 days ago Just a tip to make your videos even more watchable so you get more views and watch time, are to take out the regular distracting music breaks, and simply talk over the images/charts, to do this you can cut back on the random b-roll. Thanks a lot for the amazing and helpful advice, keep it up! 3 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Thesan Thesan 11 days ago (edited) Thank you @wellness messiah for the very valuable information. I was wondering why Dr Peter Atia recommends zone 2 training as the most effective exercise to enhance longevity pls... which seems to not align exactly to your discussion? Reply Ken Carey Ken Carey 2 weeks ago Best wishes to you and your wife ❤️ 1 Wellness Messiah with Rimon Reply Gustavo Panesso Gustavo Panesso 13 days ago Great information 🙂. 👍 1 Wellness Messiah with Rimon Reply Spoudaois Spoudaois 10 days ago My plan is to lift weights, bike and walk as much as I want on a low protein plant based diet, and maintain my ideal body weight as per the formula. There is a protein myth and most people think the more the better but animal protein in particular becomes toxic as one approaches 50 and loses one ability to clear TMAO. Reply MSCT MSCT 10 days ago Cool video! Excited to have found your channel. Reply cassopeia9 cassopeia9 11 days ago How about voluntary breath holding? This should cause hypoxia also (albeit without physical activities) but is the benefit the same? Reply jhillmd jhillmd 11 days ago Great video. Thank you. Reply Steven P Steven P 11 days ago You need to weight train so you can do HIIT. You do both. You must keep your joints and muscle strong by weight training. Reply Ed White Ed White 2 weeks ago Since fasting is good and exercise is good how about combining them and exercising while fasted? 1 Wellness Messiah with Rimon Reply 1 reply Addictive RC Addictive RC 7 days ago As a competitive Cyclist from age 30 to 50 years old I had my fastest Time trial pace from age 40 to 50 years old. so not sure about the age thing. Reply Dan Toledo Dan Toledo 9 days ago Hi, can Tennis be considered Hyper intensity interval training?? Reply Arhu Arhu 4 days ago Blagosklonny (the person that first postulated that rapamycin would extend life) recommends high protein/meat/low carb diet for longevity and unlike Sinclair Blagosklonny is an actual MD who worked with humans, that often die of frailty whereas Sinclair's lab mice almost exclusively die from cancers Reply Joey Quintin Joey Quintin 13 days ago Great info! Thanks! 1 Wellness Messiah with Rimon Reply _A_N _R_I _A_N _R_I 12 days ago A great video. What do you think of swimming and diving sometimes? Or just swimming? 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Chris Bera Chris Bera 8 days ago what about holding your breath for hypoxia? Reply SW SW 11 days ago While there are many factors as to why people in the blue zones live the longest and are the healthiest, just follow what they eat and how they live as much as you can. Moderate exercise daily, lower stress, a diet high in vegetables and maintain social interaction. No studies needed as they are on ongoing study. Reply Don Rechtman Don Rechtman 5 hours ago NOTE: Do not exercise in an underground or enclosed garage! Petrol toxins and Carbon Monoxide can reach dangerous levels. (Such as in the garage seen at 38:58.) Reply jack buaer jack buaer 13 days ago High amounts of exercise are probably not all that detrimental when we look at extreme endurance athletes ( cyclists and marathoners). Tour De France athletes have extreme workloads. Olympic male marathoners (who have extreme workloads) beat out the other male Olympic track field athletes in terms of longevity in the study below 1. "One analysis compared 834 cyclists who rode the Tour de France from the 1930s-1960s and found that they lived, on average, eight years longer than the general population. Another study examined all 786 French competitors in the Tour from 1947-2012 and found they lived on average six years longer." Does endurance cycling help you live longer?, BBC News, May 27, 2014 2. "We identified a death date for 336 of 429 (78%) Olympic athletes including 229 males (55 marathon, 56 100-m 58 high jump, 60 discus), and 107 females (54 100-m, 25 high jump, 28 discus). Discus throwers were heaviest and marathon runners the lightest and oldest athletes (p < 0.01). Observed-expected survival was highest for high jumpers (7.1 years for women, 3.7 years for men) and marathon runners (4.7 years for men) and lowest for sprinters (−1.6 years for women and −0.9 years for men). " Lee-Heidenreich, J., Lee-Heidenreich, D. & Myers, J. Differences in life expectancy between olympic high jumpers, discus throwers, marathon and 100 meter runners. BMC Sports Sci Med Rehabil 9, 3 (2017) 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies Michael Dillon Michael Dillon 3 days ago I think the aim of medicine should be healthy life span rather than longevity in itself . The lifespan has increased a lot in the UK but by age 60 many people are already on medicine for inflammatory or metabolic disease . By 70 many people are on on polypharmacy which the great Dr Jason Fung calls life support. Reply Roy King Roy King 8 days ago Qestion: How can you really know "why" someone does something? Perhaps you mean to say, "HOW Some People exercise incorrectly for longevity." Reply Ramkumar Egambaram Ramkumar Egambaram 2 weeks ago If intense exercise triggers autophagy sprinters, marathon runners should have had longevity right? But beginning of talk had reports which indicated otherwise, am I missing something? 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 4 replies Response Digital Media Response Digital Media 2 weeks ago Thanks, well done! Have you researched BFR bands? I think as a bio-hacker you would be very interested in them. 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies Christopher Ellis Christopher Ellis 2 weeks ago (edited) My father died at 84, from blood poisoning. He didn't drink or smoke, and was not a vegetarian. Swim underwater for 25 to 30 metres is one way. In between sessions in the sauna. 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies VegetablesGoOff VegetablesGoOff 10 days ago At 20:00 you can see all cause mortality change from 90 minutes moderate exercise roughly equals that from 30 minutes intense exercise - no doubt a few confounding variables of course Reply Glenn Thorn Glenn Thorn 11 days ago What about big dog versus little dog life span, this probably applies to humans 1 Reply Alan&Ann Massengale Alan&Ann Massengale 10 days ago Good info, but hypoxia is pronounced with a short "o", not long- as in "ox." Reply Michael Dillon Michael Dillon 3 days ago It is wrong to say Olympians don't take performance enhancing drugs The London Olympics ( which was called the Clean games ) has so far turned up 139 cases of doping including 13 gold medallists . They may not have been steroids but they may be drugs that enhance performance but reduce lifespan . Maybe performance enhancing drugs do not help high jumpers which may be a matter of technique ? Reply Julie Villia Julie Villia 11 days ago Amazing thank you Reply Karl Gruen Karl Gruen 5 hours ago Bodybuilding is high intensity interval training if you train close to failure. I do not understand your reasoning. It also increases muscle mass that is extremely important as you age, especially for quality of life and decreasing the risk of falls. You need to see the whole picture here. Reply Spoudaois Spoudaois 7 days ago I don't think the weight lifting is at all harmful and actually is beneficiary. Its more likely the diet the lifters are on is high in toxic protein and lipids. Bodybuilding probably wouldn't exist if they couldn't sell whey protein powder. The high jumpers probably do well because they are on calorie restricted diets to stay light. Reply Daniel Budney Daniel Budney 4 days ago You seem to be conflating muscle damage with genetic damage. The confusion doesn't affect the data on exercise and longevity, but it does cast doubt on your reasoning (and raise concern that you've subconsciously curated clips and charts that support your conclusion, instead of a more balanced sample across all the literature). Reply Carl Carl 11 days ago I thought hypoxia caused damage to the brain:/ Reply alexander boldizar alexander boldizar 12 days ago This is so deeply wrong that it just serves as an example of how people should digest information with discretion. Exercise is about a lot more than autophagy, and suggesting that people would be better off exercising less frequently is very bad advice for 99.5% of the population. The way you use bodybuilders as an example of how exercise can be unhealthy captures the entire video's approach. You say, "Some will claim it's because these bodybuilders use steroids, but if more exercise were truly better you'd expect that to overcome the steroids." Huh? Why? Should exercise also overcome smoking, getting hit by a truck, etc.? And if they still die from that truck impact, it proves exercise doesn't work? Absurd-level, disingenuous and harmful nonsense. 3 Reply Greywolf Greywolf 9 days ago Hope your wife is well… Reply mark veen mark veen 2 weeks ago When I see obese olympic discus throwers doing pirouettes. I'm not suprised by these findings. But i'm pretty sure if you would add tennis players, they would beat everyone including high jumpers longevity wise. 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Anita Jack Anita Jack 10 days ago It's quite been frustrating to watch my crypto fall Repeatedly over the last few months. Any ideas on how I could increase my profits in this market? 2 Reply 19 replies Ertan Baykal Ertan Baykal 2 days ago I have lots of theory but no data. No data no information. It is like a love story. Reply Spoudaois Spoudaois 10 days ago Bodybuilders do seem to die early from heart and kidney disease. Its blamed on the steroid usage but their diets are terrible. They ingest high amounts of animal products which contain saturated fat and cholesterol . In addition the high amounts of animal protein increase their risks due to TMAO , a highly inflammatory molecule that damages blood vessels and joints. Reply 1 reply Kriss Wegemer Kriss Wegemer 11 days ago Are there any studies that show that autophagy actually exists in humans? Only asking because the only study that I have seen mentioned was done on yeast. Reply Philly3458 Philly3458 12 days ago There is no datA suggesting a vegetarian diet will lead to longevity. Rather just the opposite. Meat based cultures live longer. 57 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 21 replies Van Paul Van Paul 7 days ago Oh damn Another Vaccination Stroke. I hope she fully recovers!!! Reply David Murphy David Murphy 7 days ago I almost clicked away when I saw your carnivorous nutrition slide, way behind the current health theories. Reply Vince Giner Vince Giner 3 days ago High jumpers.... run... jump... sit down...rest. what's to figure out? Reply WelcomeToLife BetweenPandemics WelcomeToLife BetweenPandemics 9 days ago Where are the studies of actual humans who lived long (90-95), who incorporated these longevity techniques or other behaviors, which through data analysis proof these theories? Why is this area of research absent of actual data and proof (not anecdotes). The data and proof is there for those things which shorten our lives (smoking, obesity, etc), but why not on the positive impact side. Until I see old people studied and their lives analyzed, I remain a skeptic....however I still exercise and life right...cycling and maintaining a good diet with good recovery, no smoking or drinking. I still feel that longevity is mainly influenced by genetics and avoidance of risky/unhealthy behaviors, and I think the data would prove that out. Reply Chris Bera Chris Bera 8 days ago The longest lived people in the world (Honk Kong,) average age 89, eat the most meat. Even the 7 blue zone groups of people eat meat. Vegetarians do not live the longest. Reply 1 reply Ivica Marusevic Ivica Marusevic 10 days ago What about WHM (Win Hof Method) for hypoxia? Reply Kenz300 x Kenz300 x 2 weeks ago (edited) You are what you eat. Your diet impacts your health. Lower stress, reduce obesity and more exercise are key to a healthy life. Obesity in children and adults is rising across the world. Fast food and sugary drinks are contributing to the problem of poor health and obesity. Eat a healthy plant based diet, fast on occasion and exercise regularly. Reduce or ELIMINATE cows milk, eggs, cheese and meat. Eat more salad greens, beans, fruit and vegetables. Eliminate fast food, snacks like cookies, cakes, chips, and sugary drinks and juices. Every adult and child should own a bicycle and ride it regularly. Regular exercise will help you sleep better. Yoga is a great stress reducer. Obesity is all too common today. Get off the couch. Get off the phone, ipad or video game. A variety of stretching and other exercises help with increased mobility. Ride to work, ride to school, ride for fun. Every city should be a bicycle city. Speak up for bicycles in your community 1 Reply Glenn Thorn Glenn Thorn 2 weeks ago you don't know why body builders don't live as long could it be other supplements such as HGH 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply Nadir Hossain Saifullah Nadir Hossain Saifullah 5 days ago No wellness possible with Messiah Only Wellness possible with Muhammad (sm) Reply Mike Mike 11 days ago I would guess by this guy's neck size that I should not want to be like him. Reply Jochen Gererstorfer Jochen Gererstorfer 8 days ago Lol, Olympic athletes not taking steroids :D Reply GENETIC BEAST GENETIC BEAST 1 day ago (edited) Autophagy isn't regenerative muscle micro- injuries are! They regenerate more progenitor cells... 1 Reply David Johnson David Johnson 6 days ago Ptx Therapy...Posture Function Performance..... Reply MALIK SHABAZZ MALIK SHABAZZ 11 days ago 8 % bodyfat l doubt that's good long term, in fact you looked to skinny more than muscluar or healthy. Reply Jen Holmes Jen Holmes 5 days ago Slow video start at the middle of the vid! 1 Reply Tony Kouros Tony Kouros 4 days ago Where Telomere theory stands here? Reply Jackie W Jackie W 10 days ago Couldn't take in what you were saying due to all the ads. Reply Felix T Felix T 10 days ago Buddy you need to condense the information and get to the point, Reply ETG ETG 5 days ago Try to make your video short. Reply Danielc Danielc 10 days ago Olympic athlete do not take ped. Sure... 😒 Reply Sean You Know Who Sean You Know Who 11 days ago This video lost me when using the body builder study. You can't expect resistance training to overcome steroid and other drugs use. That is hardly a scientific conclusion. It's actually a compromised set of data. Reply theluckyman74 theluckyman74 6 days ago Vegetarian people tend to have less life threatening diseases like cancer and MS. Possibly also less likely to die from infections. Reply 1 reply Gregory Lawler Gregory Lawler 11 days ago this guy talks toooo much and is very annoying .... he takes 54 minutes and he could say it more clearly in 14 minutes - summary = he is a pain to watch .. Reply Don Rechtman Don Rechtman 5 hours ago Dr. Hans Seyle made the distinction between stress and distress: "He later coined the term "stress", which has been accepted into the lexicon of most other languages. Selye argued that stress differs from other physical responses in that it is identical whether the provoking impulse is positive or negative. He called negative stress "distress" and positive stress "eustress". https://en.wikipedia.org/wiki/Hans_Selye Reply jack buaer jack buaer 13 days ago The science for longevity is not just about intense exercise. We have much more moratlity data on minimum exercise levels compared to HIIT. More specifically, for adults 60 and older, the risk of premature death leveled off at about 6,000-8,000 steps per day, meaning that more steps than that provided no additional benefit for longevity. Adults younger than 60 saw the risk of premature death stabilize at about 8,000-10,000 steps per day." 8000 steps daily is maybe a 30 minute jog or 80 minutes of walking daily Paluch AE, Bajpai S, Bassett DR, Carnethon MR, Ekelund U, Evenson KR, Galuska DA, Jefferis BJ, Kraus WE, Lee IM, Matthews CE, Omura JD, Patel AV, Pieper CF, Rees-Punia E, Dallmeier D, Klenk J, Whincup PH, Dooley EE, Pettee Gabriel K, Palta P, Pompeii LA, Chernofsky A, Larson MG, Vasan RS, Spartano N, Ballin M, Nordström P, Nordström A, Anderssen SA, Hansen BH, Cochrane JA, Dwyer T, Wang J, Ferrucci L, Liu F, Schrack J, Urbanek J, Saint-Maurice PF, Yamamoto N, Yoshitake Y, Newton RL Jr, Yang S, Shiroma EJ, Fulton JE; Steps for Health Collaborative. Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts. Lancet Public Health. 2022 Mar. 1 Reply Wellness Messiah with Rimon · 1 reply