Metformin

# #Lifespan #Healthspan Metformin - New Longevity Research is Game Changing! Fundraiser Dr Brad Stanfield 134K subscribers Join Subscribe 2.9K Share 72,291 views Jan 9, 2022 Metformin is a molecule that I personally took because of initial encouraging data. However, a massive 2021, randomized, placebo-controlled trial was published showing that for non-diabetic people, there was no benefit from taking metformin. Here is the latest metformin research: https://diabetesjournals.org/care/art... My full supplement stack: https://drstanfield.com/my-supplements/ Supplements I source from Amazon: http://amzn.to/3o2ULOV ✨10% Discounts✨ DoNotAge.org: CheckWithYourDrFirst (https://bit.ly/3lymvgI ) Alive by Science: CheckWithYourDrFirst (https://bit.ly/3esxO69 ) ProHealth: CheckWithYourDrFirst (https://bit.ly/37jzknx ) Donate towards my Rapamycin & Exercise clinical study: https://bit.ly/3QwugRx ✔️ Look & Feel 5-Years Younger in 90-Days: https://drstanfield.com/5-years-younger/ ✔️ Twitter: https://twitter.com/BradStanfieldMD ✔️ Patreon: https://www.patreon.com/bradstanfieldmd Here are the links to the research papers referenced in the video: https://pubmed.ncbi.nlm.nih.gov/18728... https://pubmed.ncbi.nlm.nih.gov/25041... https://www.sciencedirect.com/topics/... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://pubmed.ncbi.nlm.nih.gov/28159... https://www.ncbi.nlm.nih.gov/pmc/arti... https://diabetesjournals.org/care/art... If you like this video please smash the thumbs up button, it really helps with the Youtube algorithm :-) #Metformin #Lifespan #Healthspan The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel. Key moments View all 657 Comments rongmaw lin Add a comment... Dr Brad Stanfield Pinned by Dr Brad Stanfield Dr Brad Stanfield 10 months ago (edited) I've made the decision to stop taking metformin due to this 2021 human trial which shows that metformin did not reduce all-cause, cancer, or cardiovascular mortality rates in people at high risk of developing type 2 diabetes: https://pubmed.ncbi.nlm.nih.gov/34697033/ I'm guttered that metformin hasn't panned out, and I'm curious to hear your thoughts. In the meantime, I've marked my previous metformin videos as [Outdated], and updated my supplement stack which you can find here: http://bit.ly/39vRnXX 87 Reply 26 replies Anon Omous Anon Omous 10 months ago One of the reasons I'm subscribed is how Dr. Stanfield is unafraid of changing his mind to new data. It's refreshing to listen to a doctor willing to switch course and go with the research. 217 Dr Brad Stanfield Reply Dr Brad Stanfield · 6 replies NA Blank NA Blank 2 months ago (edited) As a 56 year old man who's definitely pre-diabetic after being on metformin for 4 months I can tell you that I've seen massive changes those changes didn't come about for the first two and a half to three months though and one of those changes is both my hunger level and my ability to lose weight I'm now able to lose weight relatively easily and in fact I've lost over 25 lb on the four months that I've been on that phone I've gone from 252 to 221 and my BMI is gone to 33 from 38 or thereabouts my proper weight is about 170 at which point I'll have a BMI of approximately 25 but if I go to a BMI of 20 I would pretty much be emaciated I have a very large barrel chest and very large arms triceps and biceps even though I'm only 5 ft 9 men who are five or six inches taller than we have more arms and shoulders often so I have a strange body type but I believe that in around 170 to 180 I'm in really decent territory anything above 180 and I will still consider myself fat anyway I'm going to continue taking metformin because I've seen enormous changes in benefits and this is only one study where there are multiple studies showing that it has many cancer prevention attributes the single study does not cancel out all the other studies 5 Reply 1 reply Chris R Chris R 10 months ago It shows why we must continually follow the scientific story in anti-aging research. It also illustrates that exercise, and good health will never go out of fashion. 94 Dr Brad Stanfield Reply Dr Brad Stanfield · 2 replies chuck becker chuck becker 10 months ago You have stayed on top of current research and you always have remained humble in light of newer findings. I respect you to the max. 59 Dr Brad Stanfield Reply Dr Brad Stanfield · 2 replies Gokhan M Gokhan M 10 months ago (edited) This is just one study. Sometimes it takes 4-5 RCTs to come to any definitive conclusion. You can see similar things with Aspirin, Vit D, Fish Oil, ACE Inhibitors (amongst people with HBP), Statin (for primary prevention). All those, if you ask me, are life extending. But they had many trials that showed mortality reduction, and some didn't (although meta-analysis suggests mortality reduction). I think I'll continue my metformin. Curbs appetite + better colon health + mTor inhibition + AMPK activator + ... 47 Reply Dr Brad Stanfield · 12 replies Bryan J. McEntire Bryan J. McEntire 10 months ago While I concur that data from this recent paper does not overtly support the taking of metformin, there may be confounding factors in the study. As stated in the paper and repeated in the video, this study was for individuals at high risk for developing type 2 diabetes. But the study still does not answer the key question, "Will metformin extend lifespan for individuals at risk for diabetes?" Your hypothesis that high-risk individuals on metformin should have seen an improvement compared to placebo might have been confounded by underlying comorbidities. To properly answer this question, the study should have had two additional matched cohorts of healthy non-pre-diabetic individuals - one on metformin, and the other on placebo. The TAME trial may answer this question correctly. BJMc Ph.D. 47 Reply 2 replies E.T E.T 10 months ago I really appreciate your work Brad! I can't for the life of me read through all of this myself even though I want to and that it is so interesting, so I really love that I can get a review from you like this! It is very helpful! 13 Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply Shusui Shusui 10 months ago (edited) It's important to note that the study also claims that lifestyle interventions did nothing as well. Very strange. Extremely sus in my opinion, this at least cannot be correct. 17 Reply General B General B 10 months ago My insulin reduction stack! 1. Alpha Lipoic Acid 2. Berberine 3. NMN 4. Apple Cider Vinegar 5. TMG 6. Pregnenolone 7. Probiotics Protocol: 1. Long term water only fasts 2. Working out / Weigh training 3. Spiritual meditation 4. Going out more and enjoying life 5. I stopped watching news as much as possible 6. Consuming less carbs. I view carbs as a treat. Do I eat cookies everyday? No! So I stopped consuming carbs every day. 7. Love traveling 8. Work life balance is key! 15 Reply gdok gdok 10 months ago (edited) It seems strange that a study conducted from 1996 to 1999 was only finally published in December 2021. In addition a study with 3,234 adults is relatively small and when taken alongside the quite short 3 year study duration it seems likely that its ability to detect statistically significant change in cancer, cardiovascular and all-cause mortality may have considerable limitations. Furthermore, after a greater than 20 year gap from the completion of the study in 1999 to final publication in 2021 it was finally published in The Journal Diabetes Care with an Impact Factor of only 19.11 - Ranking 181 (2020 figure). This places the medical journal Diabetes Care a long way down the Impact Factor Ratings for scientific journals compared to the top two ranking Medical Journals - The New England Journal of Medicine (USA 🇺🇸) & The Lancet (UK 🇬🇧) with Impact Factors of 91.245 & 79·321 respectively. Remember, this is only one study. The jury may still yet be out. 12 Reply 1 reply TomorrowKnows TomorrowKnows 4 weeks ago Thank you, Dr. Stanfield. I always appreciate your study reviews. How would you guide people who are pre-diabetic or even early stage diabetic (Type II), but who exercise regularly- that is, to maximize the health benefits of exercise? Reply Jose Antonio Garcia Jose Antonio Garcia 10 months ago As you suggested in past videos, I have been taking Berberine instead since metformin is a prescription substance in my country. Question is, due to the 'similarities' between them, do you think the same conclusions would apply for both? Or on the contrary you would switch to berberine instead? 27 Reply 2 replies Jeff Gilligan Jeff Gilligan 10 months ago Dr. Brad is the best source of information regarding longevity and other important health matters (such as nicotinamide riboside) on the internet. Thanks. 13 Dr Brad Stanfield Reply Joseph J Roy Joseph J Roy 10 months ago (edited) The increase in human lifespan to occured with patients receiving Metformin, in the first study you quoted, might be due to the fact that diabetic patients regularly visit their doctor while non-diabetic patient do not. While visiting their doctor for their diabetes, the doctor also checks for other health factors (Triglycerides, high blood pressure, LDL, weight, cancer,...) and, as such, can intervient to prevent all-causes mortality. 44 Dr Brad Stanfield Reply Dr Brad Stanfield · 9 replies Mehmet Çirkin Mehmet Çirkin 10 months ago (edited) There are hundreds of studies that shows metformin extends lifespan. Only 1 trial against these hundreds of trials is not wise enough to give up metformin. 39 Reply 10 replies Paul Wolf Paul Wolf 10 months ago What I like about this is that it gets right to the bottom line. This is the difference between a clinician and an academic. I am more in line with the thinking of an MD who actually treats patients, and has to live with results if things don't go well, than someone who will tweak their mathematical model when the data doesn't add up. Still, there is a problem. My assumption has been that metformin, rapamycin and berberine all did the same thing, which was inhibit MTOR and stimulate AMPK, and autophagy. Maybe this isn't actually good for you. How are you going to incorporate this new info into your own rapamycin + exercise trial? 23 Dr Brad Stanfield Reply Dr Brad Stanfield · 5 replies gabriel sido gabriel sido 10 months ago I worry this will be the case with rapamycin too. Promising preclinical/ clinical data ( like Metformin, aspirin, keto, vegan, low fat diets, acupuncture, joint manipulation etc) and ends up being useless in the end. I look forward to you clinical trial Brad. 2 Reply 1 reply tigerhawk1138 tigerhawk1138 10 months ago Because this study did confirm diabetes prevention, I will continue taking Berberine (as a substitute for Metformin) to counteract both glucose-raising potential & lipid synthesis inhibition of rapamycin (though in low-dose rapamycin the severity of this effect remains currently unknown). Also Berberine is cheap, an appetite-suppressant, & can help with weight loss. 27 Dr Brad Stanfield Reply Dr Brad Stanfield · 6 replies Ian Sane Ian Sane 7 months ago (edited) I’ve been taking 1x150mg Lipo Berberine for 12 days and stopped limping from my osteoarthritis in my right hip. Hope this continues!No pain of stiffness as well. 2 Reply E Schmitty E Schmitty 7 months ago I noticed when getting off it after two years I was considerably stronger when weight training. Intermittently taking it makes most sense to me. Diabetes runs strong in my fam, I think its worth taking occasionally. 1 Reply Creighton Freeman Creighton Freeman 10 months ago I'm waiting for the results from the TAME study. I try not to form conclusions based on one study even if the protocol and data analyses seem to be sound. Replication lends credibility. 11 Reply Plastic Fan Plastic Fan 10 months ago Although I haven’t read the last long term clinical paper (and I apologize for that) I would like your opinion on a couple of things. The first is about patient compliance and standardization of evaluation: it is really a challenge to have so large clinical cohorts for so long under standardized and controlled treatments and be certain about their compliance and about a plethora of additional confounding factors happening in their lives that are not sufficiently monitored and even potential biases in the evaluation process, the outcome measure and among the different independent data evaluators etc. There are also other examples of difficult to monitor phenomena for so long such as the false feeling of protection that patients get even in double blinded studies leading to their erratic compliance. A second issue is the measured overall death rates. This could be a bit misleading as the mortality of an illness does not only depend on an ‘objective’ level of severity but on a highly subjective one. So a pretty mild case of cardiovascular sequalae could be lethal to a diabetic patient but not to a high risk patient. The concept of incidence on the other hand would have been more insightful as it would have shown the risk of developing a life threatening condition regardless of whether it would be lethal or not. Therefore is it possible that a metformin protective effect on developing a life threatening (other than diabetes) condition per se, could have escaped our attention? 2 Reply tom brow tom brow 10 months ago Hi Brad I just wanted to thank you for these informational videos, you make the science both accessible and informative. Thank you very much. Reply Alejandro Soza Alejandro Soza 10 months ago Great information here. I am an hepatologist and I was not aware of the long term observational results of the DPP study. Just subscribed to your channel and looking forward to more good content! Reply Success From Chess Success From Chess 10 months ago I'm grateful for your being diligent in your past education and ongoing self-education, and of course your sharing with integrity. Thank you for your efforts. 11 Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply Wolfgang Icarus Wolfgang Icarus 7 months ago Love these videos, you back up what you're saying with actual peer reviewed studies. Reply Yowwall Yowwall 8 months ago Thank you so much for this video! My doctors are currently speculating if I should get NovoRapid before meals or take metformin. My diabetes is likely from a IgG4 related disease where they think my pancreas doesn't keep up after two episodes of pancreatitis. One doctor was pushing for metformin because my diabetes acts more lika type 2 one, but I was so worried about it affecting my training performance (I play sports and still improving i muscle gain, still under 30 years old). This really helped me make my decision, I will continue with only nutritional treatment for a few years more if they push for metformin. My HbA1C is around 46 still with only nutritional treatment. Hoping to get insulin though don't think it would be a high risk medication in my case. What do you think about my case? Thanks again for a good explanation. Reply Naeem Ravat Naeem Ravat 4 days ago My Metformin adventure started 8 weeks ago. My weight has dropped from 210lbs to 190lbs from Sept/22 to Nov/22. I'm not pre-diabetic, so I'm taking it off-label. Motivated after studying Dr. David Sinclair, (my son said we should be guinea pigs and do this experiment} taking Berberine, Resveratrol, NMN and practice regular intermittent fasting. He is doing it for longevity to live to 150 years. I am doing it NOT to extend my life but to reverse my biological age so that I have the cardiovascular performance, physiology and hormones of a 20 year old cyclist, yogi at the age of 100 years. I take Metformin rather than Berberine as Metformin is David Sinclair's first choice before Berberine. My target weight is to lose another 30lbs to get down to my college weight of 160 pounds over the next 3 months. I regularly fast and eat OMAD (one meal a day) and am active every day either cycling or yoga. Reply Gigi Hadeed Gigi Hadeed 7 months ago Thank you so much, Doc. Metformin seems to continue being widely prescribed for cancer patients. I guess the oncologists hadn't kept up with new info - rather negligent! I was aware of a cancer trial using patients with metastasized brain cancer - none survived beyond 2 years. I didn't think the survival rate was stunning - and now, I know why. Reply Guillaume Champeau Guillaume Champeau 10 months ago Question: I am 37 - so approaching my 40s. What would you change in your stack if you where my age? Would you already consider supplementation with ALCAR, NR, etc.? 2 Reply Order66exe Order66exe 10 months ago Many continue to make the mistake of confusing life-span and reversing biological damage. Taking metformin continuously does not equal longer lifespan. However taking metformin when someone has made a mistake in diet and has done damage to their body can help correct that mistake. 10 Reply jarichards99utube jarichards99utube 10 months ago (edited) Thanks for the update. I love it when medical doctors - * Do their own medical science reviews & * have the Mental Flexibility to CHANGE THEIR MINDS when the QUALITY Science changes. BRAVO...! THANK YOU... 3 Reply Dadnatron Dadnatron 10 months ago Be careful making decisions based upon the 'latest' study to come out. I've been in medicine for over 25yrs and seen pendulums swing back and forth massively. Medicine is truly an art, and physicians only practice it. I don't know what the final thoughts on metformin will truly be, however, I do think that there are downsides concerning exercise, and modification makes sense. But I don't think this single study has enough power to sway be away from it entirely. Previously I was going to simply move it to 'off workout' days. However, I've already decided to begin engaging a long 5-7day fast once a month, and have decided that I will be incorporating Metformin, Fisetin, and Quercetin ONLY during that time. My goal for those medications is autophagy, as is my goal for fasting. Given the safety profile of metformin, I believe the downside is truly acceptable given the continued potential upside. I'll just suck up the lack of gym benefit, for that week. 12 Reply Raul Martinez Raul Martinez 10 months ago (edited) Just listened to your episode as a guest in the Siim Land podcast. Great conversation 💯👌🏻🙂 and yes Metformin is a powerful compound, I've tried the extended release, generic and at different doses, can't tolerate it, I'll go hypoglycemic to the T and feel like 💩😂. Anyone with great fitness and insulin sensitivity will not benefit much from this compound. However, I'm glad it's readily available over the counter at pharmacies in Mexico, we have a serious problem of diabetes and obesity. 18 Dr Brad Stanfield Reply Dr Brad Stanfield · 3 replies Thomas Walz Thomas Walz 10 months ago (edited) You had me with your earlier suggestion. I approach prescription drugs with caution. I know... odd that I trust supplements (that I do research). I have diabetes in my genetics. Father was type 1, all his siblings were type 2, my sister is type 2. Ive been diagnosed as "high normal." Curious, I began taking Berberine for its effect on my diabetic numbers. I've also Morton neuroma in my right foot. The Berberine remarkably made this neuroma almost disappear. I could wear shoes all day long now, whereas before, I'd last 4 hours, or less. Recently, my supply ran out. The neuroma is slowly returning. I will be taking Berberine for life. Please look into the information on Berberine. I've gotten great results... but I'm just one human... your resources will be greatly appreciated. 1 Reply Octavian Toader Octavian Toader 10 months ago Dr. Brad great video again! What about berberine? Will these studies also affect the berberine recomandation? Or would it be wise to wait for more data here? 5 Reply Christina Johnston Pérez Christina Johnston Pérez 10 months ago Thank you millions dr Brad.... You are one of the not so many who follow science wherever it takes you even if contradicts what you have been following. I love you tons. I am diabetic and I will keep taking it of course. Reply Sheila k.raman Sheila k.raman 10 months ago (edited) We should also remember that pharma companies would be so unhappy if ppl could prevent lots of diseases with something as cheap as metformin. Therefore, we may never know what is the actual truth till we try it ourselves and on our loved ones. I have and it changed my life. I will wait for other studies. Lets see 10 Reply 1 reply iniesta iniesta 10 months ago Thank you Dr Brad. It's a unique channel and always present latest information. Looking forward to see similar human research from Rapamycin. Reply Connor Connor 10 months ago Are there any interactions between APOE4 and metformin? Would be fascinating to see, since APOE4 is one of the largest genetic risk factors of type II diabetes and A.D. Reply Tickbird Trader Tickbird Trader 10 months ago Very good video! Thank you for being so honest. I greatly appreciate the work that you are doing. 🙂 Dr Brad Stanfield Reply John C. John C. 10 months ago Great video. It's a wise man who updates his views and outcomes as new and credible information is discovered. Thx for passing this info along Dr. Stanfield. 2 Reply Nick Nero Nick Nero 10 months ago Yeah, I was pre-diabetic but had convinced my PCP to keep me on Metformin for the life extension, disease prevention benefits so kind of bummed by the latest research I've seen. 2 Reply Scott Miller Scott Miller 10 months ago I appreciate how you're always straight with us. 1 Reply Bill99 Bill99 10 months ago I started taking metformin about 3 months ago. 500mg twice a day. I'm very healthy and I take it for the long term benefits. Now, all that is called into question. But here's my dilemma: before metformin my fasting glucose was around 91. Now I check it several times a week and it's around 83. That's a good drop and I assume that's a good thing. But I'm not a doctor. 28 Reply 3 replies Chad Boomershine Chad Boomershine 10 months ago I agree, current data does not support metformin. Unfortunately, TAME results will not be out for 6 years. Great catch on finding this article Brad. 1 Reply natnut2008 natnut2008 10 months ago One thing the latest study might have got wrong is the excessively high dose of metformin administered to the test subjects : 850 mg bd. Perhaps if they had scaled back the dose, there might have been a positive increase in life span. 3 Reply Piotr Sitek Piotr Sitek 5 months ago Brilliant review of those studies. Thank you so much Dr Stanfield! Reply Brent Nally Brent Nally 9 months ago Very important insights in this video. I’ve recently stopped taking Metformin for other reasons not mentioned in this video so this video was more reasons for me to no longer take Metformin. Thanks Brad! Dr Brad Stanfield Reply WhatIsAModel WhatIsAModel 9 months ago I think metformin is still a decent choice for me as a shift worker. I eat late and sort of close to bed. Metforming will help prevent me getting diabetes. Regardless if im prediabetic or not my lifestyle is conducive to prediabetes. 1 Reply Anna P Anna P 9 months ago Honestly Doc, one can go crazy if they follow advice in your videos. One week there is a miracle supplement and another you present research against it. Reply Dr Brad Stanfield · 1 reply Grace Singer Grace Singer 8 months ago I actually was prescribed metformin for PCOS and it was great for the first 6 months but as I got closer to the one year mark of taking it, it stopped working and it was so hard for me to build muscle while on it ( I’m also only 22) so I’m not sure if one can become resistant to it?! Apparently I’m not the only one tho heard many women experienced the same thing when it comes to PCOS Reply Donna Zasgoat Donna Zasgoat 2 months ago I'm curious about the change in gut biomes due to Metformin. Saccharin and NutraSweet also alter gut biomes. I already have digestive issues due to now cured HCV and don't want the GI issues associated with metformin. I am stable on 17 units of insulin with A1Cs lower than 5. I completely overhauled my diet to achieve this. There are plenty of wiser food choices that I now love. It isn't all about depriving yourself, it's about how yummy foods without all the added salt and sugar can be. Reply Jeff Little Jeff Little 10 months ago This seems to point to another possible issue. If you take a remedy that has a certain benefit, it is likely that a relatively short coverage period will prevent that particular problem from being the tallest tent-pole, but even sustained use after that for long periods will do nothing to shorten other tent poles and in some cases might even make other tent-poles longer. I am starting to thing that treatments like the new one Sinclair is working on might have the best hope. Reply Laurin Carmichael Laurin Carmichael 9 months ago This study also claimed that there is no reduction in mortality in the lifestyle group which supposedly had at least 150 minutes of weekly exercise and >=7% body weight loss. That seems unlikely. I still believe weight loss and exercise are good for you and I will continue taking metformin in until the TAME study is published. 6 Reply Borje Lindh Borje Lindh 6 months ago Question: I'm an 61 year old powerlifter who have been resistance training for +42 years and was diagnosed with diabetes type 2 in December 2021. I know I did not have it in 2016. But the last couple of years my training results have become worse, I have needed longer rest between sets and felt sore longer between sessions. I train strenght 4 times per week + some cardio. I'm now taking both metformin and ozempic. Feel better and my blood sugar is now normal. I have also dropped 7-8% in weight. But I still feel that I'm not making much training progress and I'm starting to believe that it's the metformin blunting the training effect. Do you have more data regarding people with type 2 diabetes who are heavily into resistance training and metformin? Reply D D 7 months ago Doc wanted to ask u, leaving aside the data and the trials, how did u feel when u were taking it?? Did it make any difference for the brief time u took it?? How do ur patients feel?? Do they see improvements? Reply Ally Frasier Ally Frasier 10 months ago Great information, thank you. In terms of the longevity and cancer outcomes, are you aware of any studies in relation to Berberine? Is there a correlation between diabetic patient's and cancer rates? Is this because many cancers are more able to grow when feeding on sugar and the insulin changes in diabetic patient's mean they are more likely to feed cancer cell's? Is there a reason to prescribe Metformin over Berberine? In terms of prescribing Metformin for pre-diabetic patient's, is this a medication that may also benefit obese teens? Thanks, great information! Reply oloblish oloblish 10 months ago I would love to see a video on Extra Virgin Olive Oil about it's Polyphenols (not just the benefit from Oleic Acid) 6 Reply 1 reply Thomas 26 Thomas 26 10 months ago Thanks Brad. Important info. I wonder whether glucose inhibitors like SGLT2 and Acarbose are better bets. 1 Reply PFP PFP 9 months ago Thank you for your honesty Doc!👍🏻👍🏻 Reply KVMD KVMD 10 months ago Thanks for the honest video, i think this is an example of how early we are with longevity studies and should refrain from recommending medications/supplementations based on extrapolation or generalization of data or based on non-human data; the number of online longevity "experts" recommending things based on very thin evidence is alarming. 3 Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply Mick Mack Mick Mack 10 months ago (edited) Hi Brad, IMO there is something wrong here. You are comparing apples and pears. Metformin was widely suggested to increase lifespan. The 21 yrs trial was only telling us that the rate of the CAUSE of death didnt differ when campared with the placebo group. This does not tell us how old the people actually were when they died. The trial was not about extending lifespan. Or did i get something wrong here? 3 Reply bellydanza85 bellydanza85 10 months ago I won’t begin taking it, then. Brilliant, thorough video as always, Dr Stanfield. 1 Reply Private Citizen Private Citizen 10 months ago Note the age cohort difference in the Lee study vs TAME protocol. The younger group group may have reduced the power through diluting an age related effect. Needs to be replicated taking these potential confounders into account. For now, as a 65 yo will continue with my TAME protocol dose of Metformin... 1 Reply 1happydream 1happydream 10 months ago Excellent Updates ! PS Please take note that Metformin is also beneficial for intestinal MICROBIOME. So...probably does not extend lifespan , but for sure ameliorate LIFE 2 Reply 1 reply pelawren pelawren 10 months ago Appreciate your update even when it means reversing your previous decisions. THANK YOU 12 Dr Brad Stanfield Reply Dr Brad Stanfield · 2 replies Takeshi Suzuki Takeshi Suzuki 10 months ago Although Metformin doesn't seem to increase lifespan and mortality of " " at this stage, what about quality of life? Much harder to quantify but I think this is a point that David Sinclair makes in saying that it's not so much about increasing the life span but increasing the quality of health in the same years. Would love to hear some opinions on this! 4 Reply 1 reply Pakistanicecream Pakistanicecream 10 months ago I have respect for the way you adjust your views with the latest released research. 1 Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply CloudNine CloudNine 10 months ago One of those mouse studies did show that a combination of Metformin with Rapamysin did show "robust lifespan extension." 2 Reply Tee Bone Tee Bone 10 months ago Personally, I did not see the advantage to taking metformin on rest days anyways. But I do take berberine and was considering dihydro berberine, now I don't think I will bother. Thank you for the frank discussion based on data. Reply Zoey Deu Zoey Deu 10 months ago The women in my family have a history of longevity (most died in their mid 90's to 100s and this was in the 1960's to 1980's which was rare) and they were healthy and independent upto the last few months of their lives. They ate a healthy mixed omnivorous diet (no fads), they moved a lot every day, they were surrounded by family & loved ones, they rarely drank, didn't smoke, and continued to stay mentally alert by working or playing card games or gardening or babysitting or doing hobbies to their late 80's. Forget supplements, just eat good healthy food, have a reason to get up every day, don't smoke and move/exercise in moderation. One thing I will mention that they didn't eat much of are vegetable oils - they used mostly lard or coconut oil (the great grandmas who lived to the 1980's did have some vegie oils towards the end of their life but for 90+ years they used lard/coconut oil). Granted there may be a genetic reason why they are long-lived (high HDL runs in the family), but lifestyle does help. And the men in the family did pretty well too: average died in their early to mid 90's - the ones who died in their 80's had smoked, or drank a lot, or were really tall. 2 Reply Rick Rude Rick Rude 10 months ago I am currently conducting an N-of-1 trial with the purpose of determining if improving motivational factors may help extend longevity. Exercising, eating right and getting enough rest are linked to greater longevity. Exercising, eating right and getting enough rest on a consistent basis requires proper motivation. I theorized that positive reinforcement might increase motivation. My preliminary findings appear to be positive; however, it will take more experimentation to definitively prove my theory. I would like to thank my assistants in the sex worker industry for their dedication and attention to detail. That's one small snatch for man, one giant leap for mankind. 2 Reply 1 reply DEB WEST DEB WEST 9 months ago (edited) How long does a dose of metformin effect exercise? Since you were taking it on non exercise days, can I assume it does not effect it after 24 hours? 1 Reply Pyriold Pyriold 10 months ago Would be interesting to know what's up with berberine. Like others i took berberine instead of metformin because metformin is a prescription drug where i live. Berberine benefits soúnded very similar but it seems to have a different mechanism behind it. Reply chuck becker chuck becker 10 months ago Although Metfrm has an excellent risk/reward profile, paradoxically, it has been implicated in peripheral neuropathy. So it serves T-2 folks so very well but then it turns around & boosts the risk of one of the maladies which so often ruins the quality of life of T-2 folks. 5 Reply Brainy1978 Brainy1978 10 months ago I still take a small amount after eating too much because it somehow feels beneficial. Too bad it doesnt slow aging. 2 Reply DigitalRaider1 DigitalRaider1 10 months ago Thanks for your honesty and information Dr.! 1 Reply L Dean L Dean 10 months ago Thanks so much for the fact-based analysis. Maybe I can skip my expensive Berberine as well?? FYI, both metformin and berberine are inotropic (like digitalis - make your heart beat harder). I kept wondering why my heart would pound if I took Berberine at bedtime. Reply Lloyd Dupont Lloyd Dupont 10 months ago Thanks for the science communication work, really appreciate it! :) Reply Pharmnivore Pharmnivore 10 months ago Metformin is known to reduce the gastric absorption of B12 and it's my experience that most doctors are not proficient at diagnosing "functional B12 deficiency". These patients are not the best statistical cross-section for health choices and eating right. They likely had problems with their Folate Cycle, which would skew most B12 tests. Unless Homocysteine and MMA tests were taken and compared competently, B12 status could not be accounted for. Furthermore, most doctors don't tell their patients to stop B12 supplementation 7 days before the blood draw for serum B12 analysis. 4 Reply rng_hearthstone rng_hearthstone 2 months ago The paper mentioned "offering modified lifestyle program to everyone" (including exercise) which simply confirms that metformin doesn't go well with exercise. This paper aside, there are multiple critical analysis papers on metformin already. One randomized trial won't defeat all those papers. Reply Joe Silkwood Joe Silkwood 10 months ago Love that you're not married to any outcome & just focus on the facts!!! 1 Dr Brad Stanfield Reply The Powerhouse of the Cell The Powerhouse of the Cell 10 months ago Hey Brad, I would love to a you evaluate the level of evidence for various covid interventions, the hype around D3 etc. Thanks 1 Reply Dano S Dano S 10 months ago Thanks for your video and for your courage in changing your stances given new knowledge! Reply Liz Mallen Liz Mallen 10 months ago Would you look into melatonin? David Sinclair is just coming out now saying it causes calcification in the pineal gland. And he has stopped taking it. I am just curious if you have any idea if it is synthetic melatonin, natural melatonin or both or if you have even seen any studies? Thank you so much Dr. Brad!!!Love your channel and studies…so grateful for you!🙏❤️ 8 Dr Brad Stanfield Reply Dr Brad Stanfield · 4 replies John Hemming John Hemming 10 months ago I don't take Metformin although I do take Berberine. I note in the paper referred to it says "While this trial has one of the longest metformin interventions in a population at high risk for type 2 diabetes, the drop-in use of provider-prescribed metformin in all randomized groups when participants developed diabetes may not have been fully controlled for in our sensitivity analyses." I would myself like to know what proportion of the participants who were not provided with metformin as part of the trial were found to have been taking Metformin, but through their own GP rather than through the trial. One can then do a reasonable estimate as to whether that is a likely figure. Given that Metformin is often provided to pre-diabetics one would expect that figure to be quite high. Similarly the conclusions of the paper that extra exercise was of no benefit also raises doubts in my mind. I would accept that the effect on participants was reasonably well controlled from 1996-1999, but I am not persuaded that that information properly informs the paper from 1999-2018. It should be possible to get the sensitivity analysis on this, however. 6 Reply 2 replies David Craig David Craig 10 months ago Good report on metformin. Many posters are wondering about taking berberine. Could you please address berberine as a substitute? I just started taking it and found it gave me new energy. Thank you! 11 Dr Brad Stanfield Reply Dr Brad Stanfield · 4 replies MISSIONCAT11 MISSIONCAT11 10 months ago a friend is married to a Type 1 diabetic. They are near 75. They both exercise regularly. They had to change doctors to get Metformin. They do value the exercise as part of a healthy lifestyle. I am sending them your video so that they can decide if the Meformin is right for both of them. The wife might decide to stay the Metformin course, while he might decide to leave Metformin to continue getting maximum health value from the exercise. I was never on Metformin due to physician resistance. I use Berberine instead. I saw your video re Berberine v. Metformin and this decided me. This video is top shelf ! Thank you. Reply pnw208 pnw208 10 months ago (edited) Longevity is a double edged sword. The greatest pain in life is losing a loved one. The longer you live the more pain you feel. Then alive but youre alive but forgotten. Im sure that hurts pretty bad too. 1 Reply 1 reply Tiat (deaging.guru) Lim Tiat (deaging.guru) Lim 10 months ago You're on a roll Brad. First taking on David Sinclair (Resveratrol) and now Nir Barzilai (TAME) - both geroscience thought leaders. Ballsy. Reply Felipe Herrera salinas Felipe Herrera salinas 10 months ago From a colleague, you are serving humanity my friend! 1 Reply Kisaruni Hofmann Ndosi Kisaruni Hofmann Ndosi 10 months ago (edited) Thanks for the update. I was always jealous of the people who didn't have diabetes but had access to Metformin. Reply 1 reply Vijaya Achar Vijaya Achar 10 months ago After I started taking metformin 500mg in the morning and night, I have felt better, no sleep coma after food, and some better feeling 2 Reply Andrew Norris Andrew Norris 10 months ago (edited) Genuine question. Does it make sense to have all rodent longevity tests done on fasted mice as well? This will determine if it is achieving the results via a cross over of pathways? If the Metformin/fasted mice live much longer than they would over the just fasted mice - then wow - that is game-changing. Most of us into longevity practice forms of fasting. As such - we cannot be sure if Metformin would help those of us who fast? 7 Dr Brad Stanfield Reply Dr Brad Stanfield · 3 replies Gold Hunter Gold Hunter 10 months ago Sounds like even metformin can't reverse the damages of too much rich foods in a species that evolved with lots of unintentional fasting. I'm gearing up for my 1st fast. It will be difficult as my wife has a deep seated instinct to keep all around her well fed. 3 Reply B. Baldwin B. Baldwin 9 months ago Doctor, I will be having this talk with my PCP and I wanted to ask, what is a good replacement for metformin? Reply Hacking The Human Time Machine Hacking The Human Time Machine 9 months ago In the long term randomized placebo controlled human study were the people on Metformin chosen to take Metformin because they had more severe Type 2 diabetes. If so then this could confound the results. Reply White Rabbit White Rabbit 10 months ago Hi Dr Brad Stanfield, I also live in the country that you do, in fact I was the lead Project Manager who digitized our northern districts covid19 response. I took my first dose about 6 months ago but unfortunately I think I am allergic to PEG as I had a prolonged reactions to it, and that's no biggie its not for everyone. Over the last 6 months I have had to find my own way forward to try and protect myself by going through various studies on the NIH website and any clinical trail studies that were being pushed through. In the clinical trails, I found something Quadramune, which had 3 of four supplements that I had on my list to get so I ended up ordering some via Amazon. The most interesting ingredient was glucoraphanin and the paper on the NIH website, it was actually enjoyable to read. I'm sending some Quadramune to a friend of mine and I came across this really interesting article discussing the "Unexpected Findings of Synergy between QuadraMune & Metformin". With Omicron on the way and no true vaccine to stop this I thought it might be worth sharing with you for your patients, providing you are allowed to give an opinioned suggestion to your patients. Another thing to look at is GABA and its relationship with TRPV1 and TRNA1 deactivation. I seen a news story of a poor guy who said his legs felt like they were on fire and had a Dr prescribed him Gabapentin, I think his fate could have been very different. Anyways, I hope you get a chance to have a look as knowledge is powerful when sharing it :) https://www.biospace.com/article/releases/therapeutic-solutions-international-reports-unexpected-findings-of-synergy-between-quadramune-and-diabetes-drug-metformin-in-animal-models-of-covid-19-lung-damage/ Reply IvanAndreevich IvanAndreevich 10 months ago Would love to hear your comments on whether it applies to berberine Reply Brian Jones Brian Jones 10 months ago Great look at the data here, appreciate your perspective and insights! Reply XPaulX XPaulX 10 months ago Thanks for the great video. Does this change or impact your views on Berberine? Reply Scotland The Insane Scotland The Insane 10 months ago (edited) Interesting that the idea behind this is that diabetics live longer. It’s pretty obvious that wider, better and longer studies would contradict that. 2 Reply Peter Milian Peter Milian 10 months ago Can you do a separate video covering the research on berberine? Alternatively, if you either think the research on berberine isn't as promising as other supplements or that there just isn't enough high quality research to have an opinion on it could you clarify this in a comment? 4 Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply Nikki Hellas Nikki Hellas 9 months ago I have been diagnosed on an off with PCOS, depending on which doctor I went to. I did some research myself and found that Metformin get help here. At the time I was living in a country that you can get metformin over the counter so I just gave it a try since so far there were no severe side effects known. It didn’t help greatly with my symptoms of PCOS. But what it did is that I automatically stayed of high sugar foods (due to less craving) and ate more according to the intermittent fasting regime. I assume this is an effect of the blood sugar levels having less of a spike and fall and being more even leveled. I was in a healthy weight range before but when I took metformin I lost about 3-4 kg. Since I’m off metformin I have more cravings for sugar and simple carbohydrates again. But then again, discipline and habit can get you the same result as metformin :) From my own experience I do believe that metformin can give health benefits but for me it was more due to the diet habits which resulted from that. I went off it either way, as the purpose of taking it was to see if it helps with PCOS. It did mildly but again, I believe it helped a bit due to eating „better“ and that can be done without the drug. Reply 1 reply Raid Asfour Raid Asfour 7 months ago I noticed my blood fasting level constantly @6 and insulin serum is 25 MOLI-LI hardly eat sugar or processed food of any kind, I also do intermittent fasting 8/16 and do weight lifting on empty stomach 3 days a week. I care really care for DR Brad’s opinion if should on metforman Reply Roy Zlatan Estevez Roy Zlatan Estevez 10 months ago (edited) As metformin is prescription-only here and I'm not diabetic or prediabetic, I've never taken it, though I've tried to lobby doctors. Will I give up on it? Depends on what other researchers make of this study in the meantime. Sinclair takes it and advocates it, I wonder if he will change his tune now. De Grey has also advocated it, but I'm not sure whether he takes it himself, and it has been advanced by the NUS and MPI aging departments, so the academic opinion is still overwhelmingly for. I'll wait and see. Naturally, if I ever become (pre)diabetic, I would of course take it. Having diabetic gangrene is probably one of the less beneficial things to have for both quality of life, and lifespan. 1 Reply Jason Koukas Jason Koukas 10 months ago So it is better to develop diabetes and start taking metformin than not developing diabetes and either take or not take metformin? That is a weird result 7 Reply 1 reply bilskro bilskro 10 months ago Is there a single supplement that both you and Dr. Sinclaire agree is beneficial to extending life? Reply Michael Berman Michael Berman 9 months ago Some studies have shown that berberine is used for similar conditions that Metformin is used for and has been reported that berberine works under the same chemical mechanism as Metformin. Reports show that berberine acts in other ways to enhance overall health as well. Has berberine ever been studied to enhance longevity in humans and animals? Very eager to find this out about berberine. 1 Reply Lawdog Wales Lawdog Wales 10 months ago Intermittent fasting with occasional long term fasting used with a low carb diet has always been better than metformin. So, I have never been tempted to take metformin. I always felt it was an unnecessary drug when your diet was on point. 1 Reply Biff Biff 10 months ago (edited) Hey Dr Brad, I posted this a few times before but I think you missed it. ITP has a huge flaw in that it’s mice with ad libertum feeding and no environmental enrichment. Molecules that mimic calorie restriction, reduces mouse calorie intake or deal with obesity (and probably diabetes) will show up well. But questionable transferability to lean, healthy and exercised humans. 1 Reply Dr Brad Stanfield · 1 reply Simon Simon 10 months ago The action of metformin for life extension is the exact reason why hard, intense resistance exercise, coupled with intermittent fasting works for anti aging and life extension. They keep excessive blood glucose and aminos used up and cleared. 19 Dr Brad Stanfield Reply Dr Brad Stanfield · 4 replies Y B Y B 10 months ago (edited) Isnt this what sinclair always said? That he took metformin on days he didnt exercise. 6 Reply Kitteh Kitteh 4 months ago This gives me anxiety. I have been on Metformin for a while, and it has been fantastic in treating my insulin resistance and keeping my weight down. But now knowing that Metformin may disrupt muscle protein synthesis, I am now perplexed whether I should get off it. But what's the point of being able to optimally build muscle if I may become insulin resistant and overweight yet again? Reply Elaine S Elaine S 10 months ago Yep, not surprised. I have insulin resistance. My doctor has offered it to me. I would rather continue to reverse IR with diet and lifestyle. I think the only way I would want to take it is if I was in a situation where I could not do IF or was not in control of my food. (Like vacation or the holidays) Metformin also lowers B vitamins and is hard on the gut microbiome. Reply lloovvaallee lloovvaallee 10 months ago My first question: what does this mean for Berberine? 18 Reply 1 reply C.U.C C.U.C 10 months ago Whats the latest results published on Berberine? Would it be the same as Metmorfin? 2 Reply Constanze Cremer Constanze Cremer 9 months ago Well, actually I think noone can be that sure of not being prone to diabetis. And I'm a bit sceptical changing my mind because of only one study. Which is for that purpose not even that big. At least I will wait for the outcome of the TAME study until then I will go on with Metformin I take since six years now for anti aging reasons only. Reply Bela Horvath Bela Horvath 7 months ago I will stop then taking metformin on my resting days. Thank you for bringing good quality data. 1 Reply Søren Sloth Søren Sloth 10 months ago This is really big news in the longevity field. A lot of really big names in metformin research... Great video 👍! By the way, have you done any videos with/on SENS RF and/or Aubrey de Grey? Reply metafa84 metafa84 10 months ago I don't have metformin available, I use Berberine, is it expectable to have the same positive and negative effects as implied by this new study? Reply Grant Falck Grant Falck 10 months ago I follow a low sugar mainly plant based diet for optimal health and longevity. When I have the occasional enjoyable relapse I take a metformin tablet. Reply Allan Kiesler Allan Kiesler 10 months ago Hi Brad, Would you recommend then that we do NOT take Berberine as it was viewed as a "replacement" for Metformin ? Reply Mark Hampton Mark Hampton 9 months ago Have you tried Berberine and/or Olive Leaf Extract, instead of metformin? Despite not being over weight and eating a healthy diet, I became prediabetic, and then diabetic. Bad genetics, and it runs in my family. I decided to use Berberine and Olive Leaf Extract, because of the side effects of metformin. I am no longer diabetic, or prediabetic. 1 Reply Angelic Annihilator Angelic Annihilator 10 months ago Hi Brad. This question is not related to this video, but in your Spermidine video, you mentioned that it can possibly help with hair loss, but through what mechanisms exactly? Thanks. 5 Reply 2 replies Mahesh Lohar Mahesh Lohar 10 months ago Thanks.I have stopped taking Metformin as it developed ED…after stopping Metformin I got over ED🥰🥰 Reply William Pryor William Pryor 10 months ago I am a Type II diabetic and I enjoyed watching this video. I have been taking Metformin since 2006. 2 Dr Brad Stanfield Reply Dr Brad Stanfield · 4 replies gdv123 gdv123 gdv123 gdv123 3 months ago Thanks for sharing this research! Reply madridista1611 madridista1611 7 months ago Were different dosis of Metformin used in this 2021 study? seems like some (if not all) were on 850mg, which is a low dosis. Reply SlamminGraham SlamminGraham 10 months ago I never started taking metformin. In the end, aging reversal medicine and treatments will look less like a pill or a supplement and more like a procedure or a more invasive therapy. Reply Mike Marable Mike Marable 10 months ago It does lower IR right? Isn’t that alone a mechanism for reducing inflammation and disease? What about the cancer prevention studies associated with metformin? It lowered my HgA1c dramatically from 5.7 to 4.9 in 3 months. I also lost 20 lbs with no other lifestyle changes. I was not eating sugar and exercising before starting to take metformin. 1 Reply Shawn McCarty Shawn McCarty 10 months ago But the 6/16, 2016 study, to which you refer, says that Metformin and Rapamycin used together, "robustly extended lifespan." This could reasonably outweigh the exercise concerns... What do you think? Reply Zanthous ザンソース Zanthous ザンソース 10 months ago Not longevity related but covid-out trial is also looking at it for long covid Reply matt sinabi matt sinabi 10 months ago I'm still gonna take it on months I don't exercise. It may not affect longevity much but I still believe it does. 6 Reply Dr Brad Stanfield · 2 replies Frank Taylor Frank Taylor 10 months ago Dr. Ford Brewer must be intrigued by this news. He tends to promote it's use diabetes or not so much. Thanks for your video, Dr. Reply Frank Taylor Frank Taylor 10 months ago Metformin made me sick to my stomach every day I took it. The Dr. would day "eat carbohydrates with it" I thought, "I thought that was the main reason I was in this diabetes jam to start with". I just went on very low carbs, frequent fasting, heavy walking workouts, and got the a1c back to 4.8. 6 Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply sanjeevp sanjeevp 10 months ago (edited) Dr. Stanfield, you should do a video on the effect of meditation on telomere length and longevity. Please review the evidence and give guidance. Nir Barzilai, M.D. is still doing a lot of studies on metformin with more to start. Wait for the next chapter! Reply Jeremiah Handcock Jeremiah Handcock 9 months ago i was coming here with high hope... including metformin, NMN and resveratrol。 But now I feel like those things are not always increasing lifespan Reply M09 M09 10 months ago Dear Mr. Brad. Do you think that Metformin could be useful for cancer patients in any case as it reduce sugar level marginally and glucose is the main energy source for most cancer cells.