OLIVIE PLUS 30X(Dr Gundry polyphenols)

Oil&Health Clinical studies Doctors Videos News Testimonials Company MyFr SHOP NOW! HOME / OLIVIE PRODUCTS / OLIVIE PLUS 30X TASTE GREEN POWER THIRTY TIMES MORE HEALTH BENEFITS IN A SPOON. So beneficent that OLIVIE Plus 30x is adopted by Doctor Steven Gundry! Preserve your body cells against oxidative damages. This rare olive oil helps you avoid serious diseases. In fact, with its uniquely high concentration of polyphenols, OLIVIE Plus 30x is particularly suitable for the preventive treatment of: strokes, hypertension, cancer, diabetes, psoriasis. Shop online OLIVIE PLUS 30X is Dr Gundry polyphenols rich olive oil from Morocco Desert. Organic and healthiest! view the certificates OLIVIE PLUS 30X chemiservice THE UNIQUE EXTRA VIRGIN OLIVE OIL THAT IS EXCEPTIONALLY RICH IN POLYPHENOLS, 100% NATURALLY. The laboratory analysis of OLIVIE PLUS 30x extra virgin olive oil produced by Atlas Olive Oils showed that this rare olive oil is naturally rich in polyphenols and particularly super packed in Hydroxytyrosol with a content of 233 mg/kg, and in Tyrosol with a content of 161 mg/kg. download the COA A COMPARATIVE RESEARCH CONFIRMS THAT OLIVIE PLUS 30X CONTAINS 30 TIMES MORE THE ANTIOXYDANT HYDROXYTYROSOL NATURALLY. The table shows the content of hydroxytyrosol and tyrosol of 22 samples of regular / conventional extra virgin olive oil taken from 4 Mediterranean countries, all historically known for producing extra virgin olive oil (Source: Hrneirik and Frische – 2004). The comparison with OLIVIE Plus 30x shows with no doubt its unique and higher richness of polyphenols. OLIVIE table WHY OLIVIE PLUS 30X HAS SUCH SPECIAL FEATURES? Simply because this oil comes from suffering olive trees surviving in a harsh rocky desert. Like the vine, it is well known that the olive tree must suffer to produce the best of itself. Because of high temperatures (up to 127°F in summer), a lot of rocks in the soil making the trees not able to grow their roots freely to look for nutrients, nearly no rain throughout the year, our olive trees stress and think they will die. So they trigger a self-defense mechanism through which they product abnormally high quantity of antioxidants. We think these antioxidants, born because of this harsh environment, are more active, more potent and this is the main reason why we obtained excellent results (illustrated by the clinical studies we made) for anti-inflammation, anti-pain, anti-diabetic effect, and anti-microbial. Olive oil THE HEALTHIEST ORGANIC EXTRA VIRGIN OLIVE OIL IN THE WORLD. The analysis of OLIVIE PLUS 30x extra virgin olive oil produced by Atlas Olive Oils showed that this oil is extremely rich in polyphenols and particularly in Hydroxytyrosol with a content of 233 mg/kg, and also in Tyrosol with a content of 161 mg/kg. Hydroxytyrosol is the most powerful antioxidant easily assimilated by the human body. It has an ORAC value indicating the antioxidant power of 40’000 μmolTE/g. According to the international laboratory method “Folin Ciocalteu”, a ‘’normal’’ ‘’regular’’ ‘’conventional’’ extra virgin olive oil has on average a content of hydroxytyrosol of: 7 mg/Kg. The hydroxytyrosol content in our organic certified extra virgin olive oil OLIVIE Plus 30x is 233 mg/Kg, by far superior! The total polyphenols amount is also very high: 1250 mg/Kg compared to a normal extra virgin olive oil: 253 mg/Kg. Comparison of Hydroxytyrosol (HT) and Tyrosol (T) rates (mg/kg) between 22 samples of olive oil from 4 Mediterranean countries and our oil OLIVIE Plus 30x. Clinical Studies made on OLIVIE Polyphenols. FOOD AS A MEDICINE OF YESTERDAY AND TODAY. It is historically proven that many evolved ancient civilizations such as Egyptians, Chinese and Sumerians, just to mention few, were accustomed to use food to care and prevent illnesses. Ayurveda, the Indian traditional medicine had been mentioning food as a therapy for more than five thousand years. Historical documents testify how food benefits have healed humans for thousand years. Even Hippocrates, worldwide considered as the “father” of the western medicine, was saying «Let your food be your medicine, and your medicine be your food». Until some decades ago, the food science was limiting itself to analyze the nutritional value of the food. Nowadays, new scientific researches have led to a bigger acknowledgement of the relationship between food and health by establishing what are the components with therapeutic properties. THE PRINCE OF FOOD STUFF. Scientific researchers unanimously agreed on the benefits of the Mediterranean Diet because it’s well balanced and rich in beneficial substances such as carbohydrates, lipids, proteins, water, vitamins and mineral salts. There are a lot of food types in this diet, but extra virgin olive oil is the most important for sure because it’s naturally rich in good fatty acids and polyphenols. These latter are necessary to keep the body under good health conditions through their antioxidant properties that protect the body from the free radical damages. Molecules olive oils OXIDATION DAMAGES CELLS. Our body is constantly bombarded by free radicals existing in the environment: sun aggressive ultra-violets, ionizing radiation from the industry, passive or active smoking, automobile pollutions, etc. For example, upon breathing, we inhalate free radicals in the form of pollution. The cells in our body are then possibly damaged and could die by such chemical reactions. As a matter of fact, the free radicals can cause all sorts of deadly diseases such as cancer, leukemia, diabetes, kidney problems, liver problems, skin problems, etc. Needless to say, free radicals also speed up the aging process. This process is comparable to the metal oxidation. Once oxidized, aluminum turns to be white, iron becomes rusty, and copper transforms into green. In the same logic that oxidation damages metals, free radicals are also harmful to your body. Of course, free radicals do not only come from the environment, they can also be produced by our body’s metabolism as a result of our diets. We need to take proactive actions to protect your body from free radicals. The solution to this problem are antioxidants commonly called polyphenols. OLIVIE has a high content of polyphenols that will help increase the body’s defense system. These antioxidants can neutralize and prevent free radical from damaging your body. HYDROXYTYROSOL, THE KING OF ANTIOXIDANTS. There are many plants that contain healthily substances and are rich in polyphenols (fruit, vegetable, pulses, nuts, mushrooms, herbs, spices, etc.), but the olive fruit is the only vegetal organism that contains the highest range of bioactive polyphenols among which Oleuropein, Oleocanthal, Tyrosol and Hydroxytyrosol. This latter polyphenol is important for its powerful antioxidant properties and its highest bioavailability as the most updated scientific research shows. Its antioxidant power consists in neutralising the oxidative effect of the free radicals and avoiding the conditions that may cause diseases. This power is measured by the ORAC test (Oxygen Radical Absorbance Capacity) and it’s equal to 40’000 μmolTE/g for hydroxytyrosol, the highest among any other existing polyphenol. THE NATURAL MIRACLE OF THE DESERT OLIVE TREES. The polyphenol quantity and in particular the quantity of hydroxytyrosol and tyrosol mainly depends on the growing conditions of the trees and in the way oil is extracted from its precious fruit, the olive. As everybody knows, an olive tree is like a vineyard, it needs to suffer to produce the best of itself. Because of the hot environment (up to 127 °F in summer), because of the the rocky soil where the roots cannot develop easily and due to the lack of water, the olive trees are so stressed that a phenomenon of panic (survival instinct) occurs. The survival instinct results in a huge increase in the polyphenols production inside olives, roots, buds, baby leaves and leaves. This abnormally high production of antioxidants is due to the phenomenon of self-defense. The olive oil produced from these stressed trees has a very high amount of hydroxytyrosol polyphenols. It also contains a good amount of tyrosol, oleuropein, flavonoids, vanillic acids, and caffeic acids which are different types of polyphenols. According to the international laboratory method “Folin Ciocalteu”, a normal conventional extra virgin olive oil has an average content of hydroxytyrosol of: 7 mg/Kg. Our organic extra virgin olive oil OLIVIE Plus 30X has its hydroxytyrosol content of 233 mg/Kg which is 30 times higher! The total polyphenols amount is also very high: 1250 mg/Kg compared to a normal extra virgin olive oil: on average 253 mg/Kg. This unique feature of such richness in active principles comes from our olive trees planted in this rocky desert. These organically cultivated desert olive trees gave birth to our exclusive line OLIVIE. graphics EFFECTS OF POLYPHENOLS RICH OLIVE TREE POWDER ON INFLAMMATION AND PAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS. Clinical trials demonstrate for the first time the potential therapeutic effect of olive tree extracts high in polyphenols against inflammation and associated pain for Rheumatoid Arthritis (RA). For more information click here. STRONG ANTI-INFLAMMATORY POWER FOR JOINTS AND PAIN KILLER. Our capsules have shown great anti-inflammatory properties, about 20% higher than duclofenac and indometacine. Without any side effects, and unlike chemical drugs (leading to stomach pain), the patient can take them everyday! This is proven by a detailed clinical study published in a famous American Journal of Biological and Pharmaceutical Research. “OLIVE OIL COMPOUND KILLS CANCER CELLS IN LESS THAN AN HOUR: ALL-POWERFUL OLEOCANTHAL”. A recent and authoritative scientific research carried out by Rutgers University and Hunter College in the USA demonstrates the effectiveness of the oleocanthal molecules. Olivie Plus 30X contains more oleocanthal than others extra virgin olive oils. For more information click here. POLYPHENOLS WITH ANTIOXIDANT, ANTI-INFLAMMATORY, ANTICANCER, ANTI-AGING AND HEART PROTECTIVE ACTIONS. We made several clinical studies on the desert olive trees organic powder: OLIVIE. More than 500.000 US$ invested on science for your benefit. Just the Joints anti-inflammation study costed 140.000 US$. In the next pages you will find all the clinical studies about the OLIVIE products. As matter of fact, OLIVIE products are backed to deep sciences as we have realized 8 clinical studies on: – lowering diabetes – lowering pain and inflammation for patient suffering from joints inflammation (3 studies realized in this). – lowering cancer tumor growth – anti-microbial effect. Last but not least, the story behind this powder is unique: We produce OLIVIE powder from suffering olive trees in a rocky desert. Because of high temperatures (up to 127°F during summer), a lot of rocks in the soil making the trees not able to grow their roots to look for nutrients, nearly no rain throughout the year, our olive trees stress and think they will die. So, they trigger a self-defense mechanism through which they produce abnormally high quantity of antioxidants to defend themselves. These polyphenols, born because of this harsh environment, are more active, more potent and this is the main reason why we obtained excellent results. CLINICAL STUDY N° 1 IN THE COURSE OF PUBLICATION IN A RENOWNED SCIENTIFIC REVIEW. Supplementation with a rich polyphenols olive tree powder reduces circulating inflammatory markers, disease activity, and pain intensity in patients with rheumatoid arthritis: a 9-week randomized, double-blind, placebo-controlled clinical trial. Dr. Shavon Jackson-Michel, Director of Medical and Scientic Affairs – D. O. Company, United States of America (USA). Dr. Adrian Lopresti, Clinical Psychologist, Australia. Ghanam Jamal and Benlemlih Mohammed, Biotechnology Laboratory, Faculty of Science Dhar El Mahraz, P.O. Box 1796, Atlas-Fez, University Sidi Mohammed Ben Abdellah, Fez, Morocco. ABSTRACT Background- Notwithstanding the way that olive fruits polyphenols and olive leafs polyphenols have been known for their natural anti-inflammatory effect in the Mediterranean countries, there is little deep scientific study to confirm these benefits. Objective- To assess the effect of rich-polyphenols olive tree powder (made of leafs, baby leafs, olive fruit and olive oil) made from olive trees planted in the middle of a rocky desert on inflammatory process and pain intensity, a randomized, double-blinded, placebo-controlled trial was conducted on human subjects with rheumatoid arthritis (RA). Methods- Seventy-nine RA patients were randomized to get either 1 g per day of olive tree powder or 1 g of placebo powder during 9 weeks. Laboratory analysis, questionnaires administration, pain intensity, disease activity score, and inflammatory biomarkers were determined at the baseline and at the end of the trial. Specialists have monitored eventual side effects and antagonistic impacts of taking the olive tree powder through the period of the study. Results- Good compliance (over 95%) with the treatment was observed, without any side effect or study intervention adverse. Significant decrease in disease activity score has shown at the end of intervention within the treated group, and between groups (P<0.0001). Compared with the placebo group, inflammatory biomarkers decreased significantly in treated participants (P<0.0001). Here are the changes noticed from baseline in treated group were -1.25 mg/L (CI, -1.75 to -0.75), -2.09 pg/mL (CI, -2.63 to -1.54), -0.82 pg/mL (CI, -1.14 to -0.49) and -1769 pg/mL (CI, -2254 to -1283) for hs-CRP, IL-6, TNF-α and PGE2 respectively. Additionally, it is important to note that pain relief and global participants satisfaction increased significantly (P<0.0001) after 9 weeks of olive tree powder supplementation. Conclusion- A net improvement in circulating inflammatory markers, disease activity, and pain intensity was observed in RA patients allocated to rich-polyphenols olive tree powder food supplement. Keywords: Rheumatoid arthritis; olive tree powder; Inflammatory biomarkers; Pain intensity; Disease activity. download CLINICAL STUDY N° 2 Supplementation with rich polyphenols olive tree powder improves fasting blood glucose and insulin resistance in patients with type 2 diabetes mellitus: a 14-weeks randomized, double-blind, placebo-controlled clinical trial. Jamal GHANAM & Mohammed BENLEMLIH* Biotechnology Laboratory, Faculty of Science Dhar El Mahraz, P.O. Box 1796, Atlas-Fez, University Sidi Mohammed Ben Abdellah, Fez, Morocco. *Corresponding author: Benlemlih Mohammed ABSTRACT Background- Despite the fact that olive tree extracts have been used for long time as antidiabetics in Mediterranean folk medicine, there are few studies on olive polyphenols providing support to this view. Objectif- To assess the effect of rich-polyphenols olive extract on glucose metabolism and cardiovascular risk factors, a randomized, double-blinded, placebocontrolled trial was conducted in human subjects with type 2 diabetes. Methods- Eighty T2D patients were randomized to receive either a daily dose of 3 g of olive tree powder (6 capsules, 500 mg each) or placebo during 14 weeks. Anthropometric measures, glucose and insulin profiles, lipid profile and questionnaires administration were determined at the baseline and at the end of the trial. Doctors assessed potential adverse effects of olive tree powder through the period of study. Results- Good compliance (over 94%) with the treatment was observed, without any study-intervention adverse and without any side effect observed. The lipid profile levels of treated group decrease significantly (p < 0.0001 vs. placebo group), while the value of HDLcholesterol raise to 51.5 ± 9.4 mg/dL (p = 0.007 vs. placebo). The daily administration of rich-polyphenols olive tree powder results in a significant reduction (vs. placebo) in HbA1c (p < 0.0001), fasting glucose (p < 0.0001), insulin resistance (p = 0.0002). The average value of fasting glucose decreases to 114.2 ± 15.2 mg/dL, which is under to the normal range defined by the American Diabetic Association. Conclusion- The supplementation with a richpolyphenols powder from the olive tree was associated in a net improvement in fasting plasma glucose, insulin resistance and lipid profile in subjects with type 2 diabetes, suggesting the potential therapeutic effect of this extract as an antidiabetic. Keywords: Type 2 diabetes mellitus; Olive tree powder; Olive tree extract; Glucose control; Randomized clinical trial. download CLINICAL STUDY N° 3 Hypoglycemic and hypolipidemic effects of phenolic olive tree extract in streptozotocin diabetic rats Wafa Laaboudi*, Jamal Ghanam1, Oumaima Ghoumari1, Fatiha Sounni1, Mohammed Merzouki1, Mohamed Benlemlih1 1Biotechnology, Laboratory, Faculty of Science, Dhar, El Mahraz, University Sidi Mohamed, Ben Abdellah – Fez – Morocco ABSTRACT Objective- The aim of the present study was to determine the effects of an olive tree extract with high polyphenols content on blood glucose level and other related parameters in streptozotocin-induced diabetic rats. Methods- Diabetes was induced in rats by intraperitoneal injection of streptozotocin (55 mg/kg bw). 72h after injection, rats with fasting blood glucose higher than 2 g/l were used for the experiments. Olive tree extract was administered for 28 d and blood glucose level was measured every 4 d. Total cholesterol, triglycerides, HDL-cholesterol, creatinine, urea, total protein, uric acid, aspartate aminotransferase and alanine aminotransferase levels, were determined at the end of the experiment. Results- The oral administration of olive tree extract contributes to blood glucose level decreasing in diabetic rats group, which was significantly lower at 4th week compared to the diabetic control rats. Moreover, supplementation by olive tree extract decreased significantly (p<0.05) the values of total cholesterol, triglycerides, HDL-cholesterol, creatinine, urea, total protein, uric acid, aspartate aminotransferase and alanine aminotransferase resulting from damage caused by streptozotocin treatment. Beside this, significant reduce (p<0.05) in heart disease risk ratio was observed for treated group (4.1±0.14) compared to untreated group (7.64±0.36), which was quite similar to normal rats (4.50±0.36). Studied olive tree extract effects were similar to those of glibenclamide, a well-known antidiabetic drug. Conclusion- Results herein obtained reveal the hypoglycemic effect of this olive tree extract, suggesting his potential use as a natural antidiabetic agent. Keywords: Olive leaves, Olive fruit, Polyphenols, Antidiabetic, Streptozotocin, In vivo. download CLINICAL STUDY N° 4 Anti-infl ammatory and analgesic activities of olive tree extract Wafa Laaboudi*, Jamal Ghanam1, Hala Aissam1, Mohammed Merzouki1, Mohamed Benlemlih1 1Biotechnology Laboratory, Faculty of Science Dhar El Mahraz, University Sidi Mohamed Ben Abdellah – Fez – Morocco ABSTRACT Objectif- The aim of this study was the in vivo evaluation of analgesic and anti-inflammatory effect of an olive tree extract with high polyphenols content. Methods- This olive tree extract was obtained from Moroccan olive fruits and leaves using an eco-extraction free of chemical solvents and toxic additives. Antiinflammatory activity was evaluated using carrageenan and histamine-induced paw edema methods. Analgesic activity of the olive tree extract was estimated against a hot plate, acetic acid induced writhing and formalin tests. Results- The extracts showed significant antiinflammatory and analgesic activities with a dosedependent manner. Anti-inflammatory activity of olive tree extract at 250 and 500 mg/kg doses was more important compared to the used standard drugs (p<0.05), in both carrageenan and histamine-induced paw edema tests. In analgesic assays, results showed that 500 mg/kg dose of olive tree extract has a significant analgesic effect through both peripheral and central mechanisms. Conclusion- Our findings suggest that olive tree extract is safe and has potential anti-inflammatory and analgesic activities, which promote this use as a food supplement against pain and inflammation related to inflammatory diseases. Keywords: Olive leaves, Olive fruit, Polyphenols, Anti-inflammatory, and Analgesic, In vivo. download CLINICAL STUDY N° 5 Eco-Extraction of Phenolic Compounds from Moroccan Olive Fruits and Leaves and their Potential use as Antimicrobial Agents Wafa Laaboudi Corresponding Author, Biotechnology Laboratory, Faculty of Science Dhar El Mahraz University Sidi Mohamed Ben Abdellah – Fez – Morocco Jamal Ghanam Biotechnology Laboratory, Faculty of Science Dhar El Mahraz University Sidi Mohamed Ben Abdellah – Fez – Morocco Mohammed Merzouki Biotechnology Laboratory, Faculty of Science Dhar El Mahraz University Sidi Mohamed Ben Abdellah – Fez – Morocco Mohamed Benlemlih Biotechnology Laboratory, Faculty of Science Dhar El Mahraz University Sidi Mohamed Ben Abdellah – Fez – Morocco ABSTRACT In Morocco, the olive harvest generates regenerates a lot of waste such as leaves and olive fruits. Valuation by the extraction of polyphenols from this waste could be a promising source. In our work, we have prepared an olive tree extract from this waste, our extract contains 148 g/l of polyphenols, 8.4 g/l of flavonoids and 39.11 g/l of o-diphenols. Polyphenols, major natural antioxidants play a key role in hundreds biological reactions. The antioxidant activity test revealed great antioxidant potential of our extract with high ORAC value 3 848 100 μmol Te/kg. The present work has as objective to evaluate the antimicrobial activity. The olive tree extract showed broad- spectrum antibacterial activity against Escherichia coli, Escherichia coli TG1, Escherichia coli DH5α, Staphylococcus aureus, Bacillus cereus, Bacillus cereus MED5 and Streptococcus agalactiae. While pure phenolic compounds (caffeic acid, ascorbic acid and quercetin) showed more limited activity. The antifungal effect of the olive tree extract exceed the antibiotics at a concentration of 3 mg/disc (p<0.05). Industrial technology can therefore exploit this extract, rich in polyphenols, in order to use instead of a synthetic antioxidants and antibiotics that could be dangerous. This would lead Morocco to enhance the olive harvest waste as an important economic source. Keywords: Olive leaves; Olive fruit; Polyphenols; Antioxidants; Antibacterial; Antifungal. download CLINICAL STUDY N° 6 Anticancer effect of an olive tree extract through his cytotoxic, antioxidant and antiangiogenic activities Laure Eloy2, Thierry CRESTEIL2,3, Jamal GHANAM1, Wafa LAABOUDI1, and Mohammed BENLEMLIH1 1Biotechnology Laboratory, Faculty of Science Dhar El Mahraz University Sidi Mohamed Ben Abdellah, P.O. Box 1796 Atlas, Fez-Morocco. 2ICSN-CNRS UPR 2301, Avenue de la terrasse, 91190 Gif sur Yvette, France. 3IPSIT, Faculté de Pharmacie, Université Paris Sud, 92290 Chatenay-Malabry, France. ABSTRACT The aim of the current study was to evaluate the anticancerous potential of a phenolic olive tree extract through his cytotoxic, antioxidant and antiangiogenic activities. The in vitro cytotoxic activity of a crude olive tree extract and his major constitutive components has been evaluated against human KB, HL60 cancer cell lines using MTS and flow cytometry. ROS production was estimated with the DCFH- DA assay. Antiangiogenic activity was evaluated in vitro on endothelial cells tube formation and the pro-angiogenic factor expression was quantified using qRT-PCR. In vitro cellular assays have demonstrated the cytotoxic effect of the crude olive tree extract. This extract reduces significantly (p<0.05) ROS produced in cells exposed to oxidative stress. Beside this, olive tree extract has demonstrated a strong anti-angiogenic activity, which was correlated with a significant decrease (p<0.05) in VEGF, angiopoietin and HIF1α expression. Basically, the evaluation of anti- proliferative, antioxidant and antiangiogenic activities could be the first step to formulate an efficient pharmaceutical product with preventive and/ or curative properties against cancer. Key words: Olive tree extract; Anticancerous; Cytotoxic; Antioxidant; Antiangiogenic. download CLINICAL STUDY N° 7 Effects of rich polyphenols olive tree extract on inflammation and pain in patients with rheumatoid arthritis: A-8-week randomized, double-blind, placebo-controlled clinical trial Ghanam Jamal, Laaboudi W and Benlemlih M* Biotechnology Laboratory, Faculty of Science Dhar El Mahraz, P.O. Box 1796, Atlas-Fez, University Sidi Mohammed Ben Abdellah, Fez, Morocco. ABSTRACT Olive tree polyphenols have been known as natural anti-inflammatory agents. The aim of the current clinical trial was to assess the therapeutic effect of an olive tree extract with high polyphenols content on inflammatory processand pain intensity in rheumatoid arthritis (RA) patients. This is a randomized, double-blind, placebo-controlled clinical trial. Ninety RA patients were randomized into two groups; treated group received a daily dose of 3 g of olive extract (6 capsules, 500 mg each) during 8 weeks, while patients in placebo group received capsules with maltodextrin. Laboratory analysis, questionnaires administration, pain intensity, and inflammatory biomarkers were determined at the baseline and the end of the trial. Doctors assessed potential adverse effects of olive tree extract through the period of study. Significant decrease in disease activity score has shown at the end of intervention in the treated group and between groups (P<0.0001). Compared to the placebo group, inflammatory biomarkers decreased significantly in treated participants (P<0.0001). The changes from baseline in treated group were -1.37 mg/L (CI, – 2.71 to -1.57 mg/L), -2.14 pg/mL (CI, -2.71 to -1.57), -1.046 pg/mL (CI, -1.50 to -0.59) and -1795 pg/ mL (CI, -2283 to -1308) for hs-CRP, IL-6, TNF-α and PGE2 respectively. Pain relief and global participants satisfaction increased significantly (P<0.0001) after 8 weeks of olive tree extract supplementation. Results obtained after 2 months of supplementation demonstrate for the first time the potential therapeutic effect of olive tree extract with high polyphenols content against inflammation and associated pain in RA.